$333+ Cheap flights from Columbia, MO to San Diego (COU - SAN)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/26. Fares are subject to change and may not be available on all flights or dates of travel.
COU — SAN
Oct 29 — Nov 51
Round-trip
1 adult, Economy
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Find cheap flights from Columbia to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Columbia to San Diego
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Best
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Cheapest flights from Columbia to San DiegoExplore the most affordable flight options available from Columbia to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 29, 2026.
Explore the most affordable flight options available from Columbia to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 29, 2026.
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1912:05 pm -
1 stop7h 56m
Mon 11/2310:45 pm -
1 stop9h 19m
Deal found 9/27![American Airlines logo]()
$348
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:15 am -
1 stop7h 10m
Tue 10/2711:21 am -
1 stop7h 20m
Deal found 9/26![United Airlines logo]()
$378
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:15 am -
1 stop7h 10m
Tue 10/276:20 am -
2 stops12h 21m
Deal found 9/26![United Airlines logo]()
$412
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:19 am -
1 stop9h 21m
Sat 10/2410:55 am -
1 stop7h 38m
Deal found 9/26![United Airlines logo]()
$418
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/24:51 pm -
1 stop6h 57m
Tue 10/610:40 pm -
1 stop9h 21m
Deal found 9/25![American Airlines logo]()
$488
Best flights from Columbia to San DiegoDiscover carefully curated flight deals from Columbia to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 29, 2026.
Discover carefully curated flight deals from Columbia to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 29, 2026.
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/212:08 pm -
1 stop7h 13m
Tue 2/910:31 pm -
1 stop9h 27m
Deal found 9/25![American Airlines logo]()
$348
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:15 am -
1 stop7h 10m
Tue 10/2711:21 am -
1 stop7h 20m
Deal found 9/26![United Airlines logo]()
$378
This American Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1912:05 pm -
1 stop7h 56m
Mon 11/2310:45 pm -
1 stop9h 19m
Deal found 9/26![American Airlines logo]()
$348
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2311:15 am -
2 stops10h 53m
Tue 10/2712:39 pm -
2 stops8h 19m
Deal found 9/26![United Airlines logo]()
$418
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/309:00 am -
1 stop5h 38m
Wed 2/311:20 am -
1 stop7h 10m
Deal found 9/27![United Airlines logo]()
$458
Last-minute flights from Columbia to San DiegoDiscover last-minute flight deals from Columbia to San Diego. Data last updated September 29, 2026 and is based on user searches.
Discover last-minute flight deals from Columbia to San Diego. Data last updated September 29, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/24:51 pm -
1 stop6h 57m
Tue 10/610:40 pm -
1 stop9h 21m
Deal found 9/25![American Airlines logo]()
$488
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/211:15 am -
1 stop9h 25m
Tue 10/611:00 am -
2 stops9h 55m
Deal found 9/25![United Airlines logo]()
$494
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:19 am -
1 stop9h 21m
Sat 10/2410:55 am -
1 stop7h 38m
Deal found 9/26![United Airlines logo]()
$418
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:15 am -
1 stop7h 10m
Tue 10/2711:21 am -
1 stop7h 20m
Deal found 9/26![United Airlines logo]()
$378
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:01 pm -
1 stop9h 01m
Tue 10/276:15 am -
1 stop9h 40m
Deal found 9/28![American Airlines logo]()
$348
This United Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:15 am -
1 stop7h 10m
Tue 10/276:20 am -
2 stops12h 21m
Deal found 9/26![United Airlines logo]()
$412
One-way flights from Columbia to San DiegoSearch for one-way flight options from Columbia to San Diego. Find affordable one-way fares based on user searches. Data last updated September 29, 2026.
Search for one-way flight options from Columbia to San Diego. Find affordable one-way fares based on user searches. Data last updated September 29, 2026.
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:14 pm -
1 stop8h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![American Airlines logo]()
$333
This American Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/287:46 pm -
1 stop5h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![American Airlines logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/208:04 pm -
3 stops39h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![Multiple Airlines logo]()
$368
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/206:36 am -
1 stop7h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![American Airlines logo]()
$374
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/208:00 am -
2 stops14h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/27![United Airlines logo]()
$380
This United Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/269:01 am -
2 stops10h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/28![United Airlines logo]()
$417
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:15 am -
2 stops20h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/23![United Airlines logo]()
$532
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/287:45 am -
2 stops18h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/25![United Airlines logo]()
$678
Find flight deals from Columbia to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Columbia (COU) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $348 (American Airlines) |
One-way from | $333 (American Airlines) |
Popular in | June |
Cheapest in | February |
Average price | $458 |
Cheapflights Fare Finder
Customize your flight search to find flights from Columbia to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 29, 2026.
Use the filters below to find and compare flights from Columbia to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Mon 10/26
3:00 pm-10:40 pm
1 stop9h 40m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$333
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Thu 10/15
5:14 pm-11:38 pm
1 stop8h 24m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$333
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Tue 2/2
12:08 pm-5:21 pm
1 stop7h 13m
San Diego
Tue 2/9
10:31 pm-9:58 am
1 stop9h 27m
$348
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Thu 11/19
12:05 pm-6:01 pm
1 stop7h 56m
San Diego
Mon 11/23
10:45 pm-10:04 am
1 stop9h 19m
$348
Quickest round-trip
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Mon 12/28
7:46 pm-11:42 pm
1 stop5h 56m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$363
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Fri 11/20
8:04 pm-9:10 am
3 stops39h 06m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$368
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Fri 11/20
6:36 am-12:12 pm
1 stop7h 36m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$374
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Thu 10/22
6:15 am-11:25 am
1 stop7h 10m
San Diego
Tue 10/27
11:21 am-8:41 pm
1 stop7h 20m
$378
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Fri 11/20
8:00 am-8:24 pm
2 stops14h 24m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$380
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Fri 10/23
11:15 am-8:08 pm
2 stops10h 53m
San Diego
Tue 10/27
12:39 pm-10:58 pm
2 stops8h 19m
$418
Showing 1-10 of 13 resultsSorted by cheapest first
Compare providers for flights from Columbia to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Columbia to San Diego in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Columbia, Missouri-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Columbia, Missouri-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Columbia, Missouri-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Columbia, Missouri-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Columbia, Missouri-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Columbia to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Columbia with our price prediction graph.
COU-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated September 29, 2026.
See what other customers who have flown with United Airlines and American Airlines from Columbia to San Diego have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.1
Comfort
7.3
Food
6.7
Boarding
7.7
Entertainment
7.1
Overall
7.4
Reviews
1 / 20
4.0
OkaySimon,Jun 2024
LAS - LAX
Crew
8.1
Comfort
7.3
Food
6.7
Boarding
7.7
Entertainment
7.1
Overall
7.4
Reviews
1 / 20
4.0
OkaySimon,Jun 2024
LAS - LAX
Crew
8.1
Comfort
7.3
Food
6.7
Boarding
7.7
Entertainment
7.1
Overall
7.4
Reviews
1 / 20
4.0
OkaySimon,Jun 2024
LAS - LAX
Related info for your journey
Find useful and relevant information for your journey from Columbia to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
National City
Chula Vista
San Ysidro
Poway
Coronado
La Mesa
Julian
Santee
Lemon Grove
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Columbia and San Diego flights
Browse other Columbia and San Diego flight options. Last updated on September 29, 2026.
Other flights from Columbia
Browse through other flights departing from Columbia. Flights are based on user searches made on Cheapflights and were last updated on September 29, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Diego
Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 29, 2026.
Top 2 airlines flying from Columbia to San Diego
Discover the top 2 airlines that operate flights from Columbia to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$288 | Average$418 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$318 | Average$459 | FlexibilityNo cancel fee | On-time71% |