$297+ Cheap flights from Columbia, MO to San Diego (COU - SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/4. Fares are subject to change and may not be available on all flights or dates of travel.
COU — SAN
Oct 1 — Oct 81
Round-trip
1 adult, Economy
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Find cheap flights from Columbia to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Columbia to San Diego
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Best
Last-minute
One-way
Cheapest flights from Columbia to San DiegoExplore the most affordable flight options available from Columbia to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 1, 2026.
Explore the most affordable flight options available from Columbia to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 1, 2026.
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:11 pm -
1 stop6h 39m
Tue 11/108:00 am -
1 stop6h 41m
Deal found 8/31![American Airlines logo]()
$328
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/48:00 am -
2 stops11h 15m
Tue 11/102:08 pm -
1 stop6h 50m
Deal found 8/31![United Airlines logo]()
$334
This American Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:32 pm -
1 stop6h 53m
Mon 9/2110:46 pm -
1 stop9h 10m
Deal found 8/28![American Airlines logo]()
$363
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/198:00 am -
2 stops11h 17m
Mon 11/2312:39 pm -
2 stops8h 19m
Deal found 8/29![United Airlines logo]()
$365
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/59:01 am -
2 stops10h 16m
Mon 11/92:08 pm -
1 stop6h 50m
Deal found 8/31![United Airlines logo]()
$369
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/49:01 am -
2 stops10h 16m
Thu 11/1211:21 am -
2 stops9h 37m
Deal found 8/31![United Airlines logo]()
$379
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/113:31 pm -
1 stop7h 59m
Tue 9/1511:15 am -
1 stop6h 57m
Deal found 8/27![American Airlines logo]()
$398
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/113:11 pm -
1 stop8h 59m
Tue 9/1511:00 am -
2 stops9h 55m
Deal found 8/27![United Airlines logo]()
$404
Best flights from Columbia to San DiegoDiscover carefully curated flight deals from Columbia to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 1, 2026.
Discover carefully curated flight deals from Columbia to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 1, 2026.
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/173:31 pm -
1 stop9h 54m
Mon 9/216:15 am -
1 stop9h 47m
Deal found 8/27![American Airlines logo]()
$328
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/48:00 am -
2 stops11h 15m
Tue 11/1012:39 pm -
2 stops8h 19m
Deal found 8/31![United Airlines logo]()
$339
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2111:15 am -
2 stops10h 53m
Tue 10/2712:39 pm -
2 stops8h 19m
Deal found 8/31![United Airlines logo]()
$339
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1511:20 am -
1 stop9h 10m
Sat 9/1912:37 pm -
1 stop6h 02m
Deal found 8/31![United Airlines logo]()
$398
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/113:11 pm -
1 stop8h 59m
Tue 9/1511:00 am -
2 stops9h 55m
Deal found 8/27![United Airlines logo]()
$404
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:15 am -
1 stop7h 10m
Tue 9/292:07 pm -
1 stop6h 48m
Deal found 8/31![United Airlines logo]()
$418
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/269:00 am -
1 stop7h 50m
Wed 9/306:28 pm -
2 stops14h 11m
Deal found 8/29![United Airlines logo]()
$424
Last-minute flights from Columbia to San DiegoDiscover last-minute flight deals from Columbia to San Diego. Data last updated September 1, 2026 and is based on user searches.
Discover last-minute flight deals from Columbia to San Diego. Data last updated September 1, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/113:31 pm -
1 stop7h 59m
Tue 9/1511:15 am -
1 stop6h 57m
Deal found 8/27![American Airlines logo]()
$398
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/113:11 pm -
1 stop8h 59m
Tue 9/1511:00 am -
2 stops9h 55m
Deal found 8/27![United Airlines logo]()
$404
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1511:20 am -
2 stops10h 42m
Sat 9/199:35 am -
2 stops9h 04m
Deal found 8/31![United Airlines logo]()
$435
This American Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/173:31 pm -
1 stop9h 54m
Mon 9/216:15 am -
1 stop9h 47m
Deal found 8/27![American Airlines logo]()
$328
This United Airlines deal was found by Cheapflights users on 8/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/179:00 am -
2 stops10h 26m
Mon 9/217:41 pm -
2 stops12h 58m
Deal found 8/28![United Airlines logo]()
$464
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:15 am -
1 stop7h 10m
Tue 9/292:07 pm -
1 stop6h 48m
Deal found 8/31![United Airlines logo]()
$418
This United Airlines deal was found by Cheapflights users on 8/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2611:19 am -
1 stop9h 21m
Wed 9/302:07 pm -
1 stop6h 48m
Deal found 8/27![United Airlines logo]()
$453
One-way flights from Columbia to San DiegoSearch for one-way flight options from Columbia to San Diego. Find affordable one-way fares based on user searches. Data last updated September 1, 2026.
Search for one-way flight options from Columbia to San Diego. Find affordable one-way fares based on user searches. Data last updated September 1, 2026.
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:13 am -
1 stop15h 02m
Deal found 8/31![American Airlines logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/161:04 pm -
3 stops50h 12m
Deal found 8/30![Multiple Airlines logo]()
$307
This American Airlines deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:14 pm -
1 stop6h 32m
Deal found 8/30![American Airlines logo]()
$323
This United Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/49:01 am -
2 stops13h 36m
Deal found 8/31![United Airlines logo]()
$329
This United Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2811:15 am -
2 stops10h 53m
Deal found 8/29![United Airlines logo]()
$402
Find flight deals from Columbia to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Columbia (COU) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 1, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $328 (American Airlines) |
One-way from | $297 (American Airlines) |
Popular in | June |
Cheapest in | February |
Average price | $443 |
Cheapflights Fare Finder
Customize your flight search to find flights from Columbia to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 1, 2026.
Use the filters below to find and compare flights from Columbia to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Thu 9/17
3:31 pm-11:25 pm
1 stop9h 54m
San Diego
Mon 9/21
6:15 am-6:02 pm
1 stop9h 47m
$328
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Wed 11/4
8:00 am-5:15 pm
2 stops11h 15m
San Diego
Tue 11/10
12:39 pm-10:58 pm
2 stops8h 19m
$339
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Wed 10/21
11:15 am-8:08 pm
2 stops10h 53m
San Diego
Tue 10/27
12:39 pm-10:58 pm
2 stops8h 19m
$339
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Tue 9/15
11:20 am-6:30 pm
1 stop9h 10m
San Diego
Sat 9/19
12:37 pm-8:39 pm
1 stop6h 02m
$398
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Fri 9/11
3:11 pm-10:10 pm
1 stop8h 59m
San Diego
Tue 9/15
11:00 am-10:55 pm
2 stops9h 55m
$404
Quickest round-trip
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Sat 9/26
6:15 am-11:25 am
1 stop7h 10m
San Diego
Tue 9/29
2:07 pm-10:55 pm
1 stop6h 48m
$418
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Sat 9/26
9:00 am-2:50 pm
1 stop7h 50m
San Diego
Wed 9/30
6:28 pm-10:39 am
2 stops14h 11m
$424
Cheapest one-way
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Fri 10/16
1:04 pm-1:16 pm
3 stops50h 12m
$307
Quickest one-way
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Fri 10/16
5:14 pm-9:46 pm
1 stop6h 32m
$323
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Wed 11/4
9:01 am-8:37 pm
2 stops13h 36m
$329
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Columbia to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Columbia to San Diego in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Columbia, Missouri-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Columbia, Missouri-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Columbia, Missouri-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Columbia, Missouri-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Columbia, Missouri-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Columbia to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Columbia with our price prediction graph.
COU-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated September 1, 2026.
See what other customers who have flown with United Airlines and American Airlines from Columbia to San Diego have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.7
Entertainment
7.1
Crew
8.1
Overall
7.4
Food
6.7
Comfort
7.3
Reviews
1 / 20
4.0
OkaySimon,Jun 2024
LAS - LAX
Boarding
7.7
Entertainment
7.1
Crew
8.1
Overall
7.4
Food
6.7
Comfort
7.3
Reviews
1 / 20
4.0
OkaySimon,Jun 2024
LAS - LAX
Boarding
7.7
Entertainment
7.1
Crew
8.1
Overall
7.4
Food
6.7
Comfort
7.3
Reviews
1 / 20
4.0
OkaySimon,Jun 2024
LAS - LAX
Related info for your journey
Find useful and relevant information for your journey from Columbia to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
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San Ysidro
La Mesa
Santee
Julian
Lemon Grove
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Columbia and San Diego flights
Browse other Columbia and San Diego flight options. Last updated on September 1, 2026.
Other flights from Columbia
Browse through other flights departing from Columbia. Flights are based on user searches made on Cheapflights and were last updated on September 1, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Other flights to San Diego
Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 1, 2026.
Top 2 airlines flying from Columbia to San Diego
Discover the top 2 airlines that operate flights from Columbia to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 1, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$288 | Average$418 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$318 | Average$473 | FlexibilityNo cancel fee | On-time71% |