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$333+ Cheap flights from Columbia, MO to San Diego (COU - SAN)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/12. Fares are subject to change and may not be available on all flights or dates of travel.
COU — SAN
Jan 3 — Jan 101
Sat 1/3
Sat 1/10
1 adult, Economy
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Cheap flight deals from Columbia to San Diego

Cheapest flights from Columbia to San Diego
Explore the most affordable flight options available from Columbia to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 4, 2025.

This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2310:17 amCOU - SAN
1 stop11h 51mAmerican Airlines
Fri 12/266:15 amSAN - COU
1 stop10h 57mAmerican Airlines
Deal found 12/2$334
This United Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:05 amCOU - SAN
2 stops11h 29mUnited Airlines
Fri 12/2612:42 pmSAN - COU
1 stop5h 46mUnited Airlines
Deal found 12/2$369
This United Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/129:00 amCOU - SAN
1 stop6h 04mUnited Airlines
Sun 12/1411:11 amSAN - COU
2 stops8h 11mUnited Airlines
Deal found 12/3$404
This United Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/188:45 amCOU - SAN
1 stop8h 16mUnited Airlines
Mon 12/229:00 amSAN - COU
2 stops10h 19mUnited Airlines
Deal found 12/3$503

Find flight deals from Columbia to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Columbia (COU) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 4, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$333
(American Airlines)
Provider with most accurate pricing for Columbia Regional-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Columbia Regional-San Diego flights.
Search Deals
From Columbia Regional to San Diego
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbia to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from Columbia to San Diego that are best for you.

Fly from

Columbia

Fly to

San Diego

Route

Depart

Return

Price

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Thu 2/12

10:07 am-8:23 pm

1 stop12h 16m

San Diego

Sun 2/15

6:15 am-6:03 pm

1 stop9h 48m

$333

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Tue 12/23

10:17 am-8:08 pm

1 stop11h 51m

San Diego

Fri 12/26

6:15 am-7:12 pm

1 stop10h 57m

$334

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Tue 1/27

8:45 am-3:04 pm

1 stop8h 19m

San Diego

Sat 1/31

11:10 am-8:33 pm

1 stop7h 23m

$338

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Sat 1/10

8:45 am-3:04 pm

1 stop8h 19m

San Diego

Tue 1/13

10:52 am-9:37 pm

1 stop8h 45m

$338

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Tue 12/23

8:05 am-5:34 pm

2 stops11h 29m

San Diego

Fri 12/26

12:42 pm-8:28 pm

1 stop5h 46m

$369

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Mon 12/22

8:45 am-12:59 pm

1 stop6h 14m

$389

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Wed 12/10

3:05 pm-10:30 pm

1 stop9h 25m

$463

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Sun 3/22

9:05 am-5:26 pm

1 stop10h 21m

$492

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/3

Compare providers for flights from Columbia to San Diego

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Columbia to San Diego in December.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Columbia, Missouri-San Diego flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Columbia, Missouri-San Diego flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Columbia, Missouri-San Diego flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Columbia, Missouri-San Diego flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Columbia, Missouri-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Columbia to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Columbia with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbia to San Diego

What is the cheapest time of day to fly from COU to SAN?

Find hourly flight availability from Columbia to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 4, 2025.

When flying from Columbia, Missouri to San Diego, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 45% versus a flight at noon.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated December 4, 2025.
See what other customers who have flown with American Airlines from Columbia to San Diego have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,047 reviews

Food

6.5

Crew

8.0

Boarding

7.5

Overall

7.2

Entertainment

6.9

Comfort

7.2

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2024

LHR - SAN

This was the best flight I have experienced in all the years I have been f doing this journey with BA. Flight, food and service A1. Well done BA.
American Airlines
7.2
Good
11,047 reviews
American Airlines
7.2
Good
11,047 reviews

Food

6.5

Crew

8.0

Boarding

7.5

Overall

7.2

Entertainment

6.9

Comfort

7.2

Reviews

1 / 20
10.0
Excellent

Anonymous,Jan 2024

LHR - SAN

This was the best flight I have experienced in all the years I have been f doing this journey with BA. Flight, food and service A1. Well done BA.

Related info for your journey

Find useful and relevant information for your journey from Columbia to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Columbia, Missouri to San Diego?

    A quick flight from Columbia, Missouri to San Diego can take about 8h 19m. American Airlines provides one of the quickest options available for as low as $338. Columbia, Missouri and San Diego are separated by a distance of 1456 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What is the cheapest airline to fly from Columbia, Missouri to San Diego round-trip?

    Our cheapest airline available from Columbia, Missouri to San Diego is American Airlines. Our recent data shows that you can find tickets from as low as $429 on this airline.

  • Can I find deals for flights from Columbia to San Diego that include hotel bookings?

    Yes. In addition to deals on Columbia to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbia to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to San Diego.

  • Can I find deals for business class flights from Columbia to San Diego?

    Yes. Cheapflights offers flight deals from Columbia to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
Coronado
La Mesa
Poway
Lemon Grove
Julian
National City

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Top airline flying from Columbia to San Diego

Discover the top airline that operate flights from Columbia to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$429Average$536FlexibilityNo cancel feeOn-time71%

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