$281+ Cheap flights from Columbia, MO to San Diego (COU - SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/18. Fares are subject to change and may not be available on all flights or dates of travel.
COU — SAN
Apr 24 — May 11
Round-trip
1 adult, Economy
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Best
Last-minute
One-way
Cheapest flights from Columbia to San DiegoExplore the most affordable flight options available from Columbia to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 25, 2026.
Explore the most affordable flight options available from Columbia to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 25, 2026.
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:43 pm
COU
- SAN
1 stop6h 13m
American Airlines
Sun 4/1910:40 pm
SAN
- COU
1 stop9h 06m
American Airlines
Deal found 3/24![American Airlines logo]()
$338
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:21 pm
COU
- SAN
1 stop8h 35m
American Airlines
Tue 5/126:30 am
SAN
- COU
2 stops8h 21m
American Airlines
Deal found 3/20![American Airlines logo]()
$344
This United Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/79:02 am
COU
- SAN
1 stop5h 50m
United Airlines
Sat 4/1112:40 pm
SAN
- COU
1 stop6h 23m
United Airlines
Deal found 3/23![United Airlines logo]()
$388
This United Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/58:00 am
COU
- SAN
1 stop9h 33m
United Airlines
Sat 5/912:40 pm
SAN
- COU
1 stop6h 09m
United Airlines
Deal found 3/22![United Airlines logo]()
$428
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/255:39 pm
COU
- SAN
1 stop6h 44m
American Airlines
Sat 3/2810:35 pm
SAN
- COU
1 stop8h 55m
American Airlines
Deal found 3/24![American Airlines logo]()
$563
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1611:30 am
COU
- SAN
2 stops10h 42m
United Airlines
Sun 4/196:20 am
SAN
- COU
1 stop6h 28m
United Airlines
Deal found 3/24![United Airlines logo]()
$663
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/126:25 pm
COU
- SAN
1 stop7h 03m
American Airlines
Fri 7/1710:45 pm
SAN
- COU
1 stop9h 07m
American Airlines
Deal found 3/20![American Airlines logo]()
$676
Best flights from Columbia to San DiegoDiscover carefully curated flight deals from Columbia to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 25, 2026.
Discover carefully curated flight deals from Columbia to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 25, 2026.
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:43 pm
COU
- SAN
1 stop6h 13m
American Airlines
Sun 4/1910:40 pm
SAN
- COU
1 stop9h 06m
American Airlines
Deal found 3/24![American Airlines logo]()
$338
This United Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/78:00 am
COU
- SAN
2 stops11h 12m
United Airlines
Sat 4/1112:40 pm
SAN
- COU
1 stop6h 23m
United Airlines
Deal found 3/23![United Airlines logo]()
$394
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:21 pm
COU
- SAN
1 stop8h 35m
American Airlines
Tue 5/126:15 am
SAN
- COU
1 stop7h 43m
American Airlines
Deal found 3/20![American Airlines logo]()
$338
This United Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/53:10 pm
COU
- SAN
1 stop9h 29m
United Airlines
Sat 5/96:20 am
SAN
- COU
2 stops12h 29m
United Airlines
Deal found 3/20![United Airlines logo]()
$434
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/126:25 pm
COU
- SAN
1 stop7h 03m
American Airlines
Fri 7/1710:45 pm
SAN
- COU
1 stop9h 07m
American Airlines
Deal found 3/20![American Airlines logo]()
$676
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/163:23 pm
COU
- SAN
3 stops30h 49m
United Airlines
Sun 4/198:37 pm
SAN
- COU
2 stops12h 18m
United Airlines
Deal found 3/24![United Airlines logo]()
$707
This United Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/59:02 am
COU
- SAN
1 stop5h 50m
United Airlines
Thu 4/910:52 am
SAN
- COU
1 stop9h 09m
United Airlines
Deal found 3/21![United Airlines logo]()
$836
This United Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/129:14 am
COU
- SAN
2 stops16h 40m
United Airlines
Fri 7/176:20 am
SAN
- COU
2 stops12h 19m
United Airlines
Deal found 3/20![United Airlines logo]()
$840
Last-minute flights from Columbia to San DiegoDiscover last-minute flight deals from Columbia to San Diego. Data last updated March 25, 2026 and is based on user searches.
Discover last-minute flight deals from Columbia to San Diego. Data last updated March 25, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/255:39 pm
COU
- SAN
1 stop6h 44m
American Airlines
Sat 3/2810:35 pm
SAN
- COU
1 stop8h 55m
American Airlines
Deal found 3/24![American Airlines logo]()
$563
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/269:05 am
COU
- SAN
1 stop5h 52m
United Airlines
Sat 5/911:00 am
SAN
- COU
1 stop7h 49m
United Airlines
Deal found 3/24![United Airlines logo]()
$428
This United Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/59:02 am
COU
- SAN
1 stop5h 50m
United Airlines
Thu 4/910:52 am
SAN
- COU
1 stop9h 09m
United Airlines
Deal found 3/21![United Airlines logo]()
$836
This United Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/79:02 am
COU
- SAN
1 stop5h 50m
United Airlines
Sat 4/1112:40 pm
SAN
- COU
1 stop6h 23m
United Airlines
Deal found 3/23![United Airlines logo]()
$388
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:43 pm
COU
- SAN
1 stop6h 13m
American Airlines
Sun 4/1910:40 pm
SAN
- COU
1 stop9h 06m
American Airlines
Deal found 3/24![American Airlines logo]()
$338
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1611:30 am
COU
- SAN
2 stops10h 42m
United Airlines
Sun 4/196:20 am
SAN
- COU
1 stop6h 28m
United Airlines
Deal found 3/24![United Airlines logo]()
$663
One-way flights from Columbia to San DiegoSearch for one-way flight options from Columbia to San Diego. Find affordable one-way fares based on user searches. Data last updated March 25, 2026.
Search for one-way flight options from Columbia to San Diego. Find affordable one-way fares based on user searches. Data last updated March 25, 2026.
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1810:16 am
COU
- SAN
1 stop15h 17m
American Airlines
Deal found 3/24![American Airlines logo]()
$281
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/266:25 pm
COU
- SAN
1 stop7h 03m
American Airlines
Deal found 3/23![American Airlines logo]()
$348
This United Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/2611:23 am
COU
- SAN
2 stops24h 45m
United Airlines
Deal found 3/23![United Airlines logo]()
$427
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/188:00 am
COU
- SAN
3 stops18h 29m
United Airlines
Deal found 3/24![United Airlines logo]()
$445
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/306:00 am
COU
- SAN
1 stop8h 41m
American Airlines
Deal found 3/24![American Airlines logo]()
$494
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/309:02 am
COU
- SAN
2 stops11h 36m
United Airlines
Deal found 3/24![United Airlines logo]()
$500
Find flight deals from Columbia to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Columbia (COU) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 25, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $338 (American Airlines) |
Popular in | December |
Cheapest in | February |
Average price | $581 |
Cheapflights Fare Finder
Customize your flight search to find flights from Columbia to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 25, 2026.
Use the filters below to find and compare flights from Columbia to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ColumbiaSan Diego
COU - SAN
COUSAN
Columbia Regional
Thu 4/16
7:43 pm-11:56 pm
1 stop6h 13m
San Diego
Sun 4/19
10:40 pm-9:46 am
1 stop9h 06m
$338
ColumbiaSan Diego
COU - SAN
COUSAN
Columbia Regional
Fri 5/8
5:21 pm-11:56 pm
1 stop8h 35m
San Diego
Tue 5/12
6:15 am-3:58 pm
1 stop7h 43m
$338
ColumbiaSan Diego
COU - SAN
COUSAN
Columbia Regional
Tue 4/7
8:00 am-5:12 pm
2 stops11h 12m
San Diego
Sat 4/11
12:40 pm-9:03 pm
1 stop6h 23m
$394
ColumbiaSan Diego
COU - SAN
COUSAN
Columbia Regional
Tue 5/5
3:10 pm-10:39 pm
1 stop9h 29m
San Diego
Sat 5/9
6:20 am-8:49 pm
2 stops12h 29m
$434
ColumbiaSan Diego
COU - SAN
COUSAN
Columbia Regional
Sun 7/12
6:25 pm-11:28 pm
1 stop7h 03m
San Diego
Fri 7/17
10:45 pm-9:52 am
1 stop9h 07m
$676
ColumbiaSan Diego
COU - SAN
COUSAN
Columbia Regional
Thu 4/16
3:23 pm-8:12 pm
3 stops30h 49m
San Diego
Sun 4/19
8:37 pm-10:55 am
2 stops12h 18m
$707
Quickest round-trip
ColumbiaSan Diego
COU - SAN
COUSAN
Columbia Regional
Sun 4/5
9:02 am-12:52 pm
1 stop5h 50m
San Diego
Thu 4/9
10:52 am-10:01 pm
1 stop9h 09m
$836
ColumbiaSan Diego
COU - SAN
COUSAN
Columbia Regional
Sun 7/12
9:14 am-11:54 pm
2 stops16h 40m
San Diego
Fri 7/17
6:20 am-8:39 pm
2 stops12h 19m
$840
Cheapest one-way
ColumbiaSan Diego
COU - SAN
COUSAN
Columbia Regional
Sat 4/18
10:16 am-11:33 pm
1 stop15h 17m
$281
Quickest one-way
ColumbiaSan Diego
COU - SAN
COUSAN
Columbia Regional
Sun 7/26
6:25 pm-11:28 pm
1 stop7h 03m
$348
Showing 1-10 of 13 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Columbia, Missouri-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Columbia, Missouri-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Columbia, Missouri-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Columbia, Missouri-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Columbia, Missouri-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Columbia to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Columbia with our price prediction graph.
COU-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated March 25, 2026.
See what other customers who have flown with United Airlines and American Airlines from Columbia to San Diego have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.1
Food
6.6
Overall
7.4
Entertainment
7.1
Boarding
7.7
Comfort
7.3
Reviews
1 / 20
10.0
ExcellentAnonymous,Sep 2025
FRA - SFO
Crew
8.1
Food
6.6
Overall
7.4
Entertainment
7.1
Boarding
7.7
Comfort
7.3
Reviews
1 / 20
10.0
ExcellentAnonymous,Sep 2025
FRA - SFO
Crew
8.1
Food
6.6
Overall
7.4
Entertainment
7.1
Boarding
7.7
Comfort
7.3
Reviews
1 / 20
10.0
ExcellentAnonymous,Sep 2025
FRA - SFO
Related info for your journey
Find useful and relevant information for your journey from Columbia to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
Chula Vista
National City
Coronado
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Julian
Lemon Grove
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Columbia and San Diego flights
Browse other Columbia and San Diego flight options. Last updated on March 25, 2026.
Other flights from Columbia
Browse through other flights departing from Columbia. Flights are based on user searches made on Cheapflights and were last updated on March 25, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Other flights to San Diego
Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 25, 2026.
Top 2 airlines flying from Columbia to San Diego
Discover the top 2 airlines that operate flights from Columbia to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$343 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$429 | Average$536 | FlexibilityNo cancel fee | On-time71% |