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$232+ Cheap flights from Columbia, MO to San Diego (COU - SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/11. Fares are subject to change and may not be available on all flights or dates of travel.
COU — SAN
Mar 30 — Apr 61
Mon 3/30
Mon 4/6
1 adult, Economy
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Cheap flight deals from Columbia to San Diego

Cheapest flights from Columbia to San Diego
Explore the most affordable flight options available from Columbia to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 28, 2026.

This American Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/246:00 am
COU
-
SAN
1 stop10h 23m
American Airlines
Tue 3/316:20 am
SAN
-
COU
1 stop12h 06m
American Airlines
Deal found 2/24$304
This United Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1211:15 am
COU
-
SAN
1 stop9h 45m
United Airlines
Mon 3/1611:03 am
SAN
-
COU
2 stops7h 17m
United Airlines
Deal found 2/25$350
This United Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/289:02 am
COU
-
SAN
1 stop7h 55m
United Airlines
Sat 5/212:40 pm
SAN
-
COU
1 stop6h 09m
United Airlines
Deal found 2/26$358
This United Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/79:05 am
COU
-
SAN
2 stops12h 43m
United Airlines
Sun 3/158:50 pm
SAN
-
COU
2 stops11h 43m
United Airlines
Deal found 2/26$396
This United Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/289:00 am
COU
-
SAN
1 stop5h 57m
United Airlines
Mon 3/27:50 pm
SAN
-
COU
2 stops12h 43m
United Airlines
Deal found 2/24$464
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2210:08 am
COU
-
SAN
1 stop12h 12m
American Airlines
Thu 3/266:20 am
SAN
-
COU
1 stop11h 59m
American Airlines
Deal found 2/25$492
This American Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/217:39 pm
COU
-
SAN
1 stop6h 20m
American Airlines
Wed 3/256:20 am
SAN
-
COU
1 stop11h 59m
American Airlines
Deal found 2/24$500

Find flight deals from Columbia to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Columbia (COU) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$304
(American Airlines)

One-way from

$232
(American Airlines)

Popular in

December

Cheapest in

February

Average price

$310
Provider with most accurate pricing for Columbia Regional-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Columbia Regional-San Diego flights.
Search Deals
From Columbia Regional to San Diego
Search Deals
One-way flight from Columbia Regional to San Diego
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($20 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Columbia to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 28, 2026.
Use the filters below to find and compare flights from Columbia to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Tue 4/28

9:02 am-2:57 pm

1 stop7h 55m

San Diego

Sat 5/2

12:40 pm-8:49 pm

1 stop6h 09m

$358

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Tue 3/24

9:05 am-3:05 pm

1 stop8h 00m

San Diego

Tue 3/31

6:20 pm-10:55 am

2 stops14h 35m

$364

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Sat 3/21

7:39 pm-11:59 pm

1 stop6h 20m

San Diego

Wed 3/25

6:20 am-8:19 pm

1 stop11h 59m

$500

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Tue 3/10

9:58 am-10:40 pm

1 stop14h 42m

$322

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Sat 3/7

9:05 am-12:57 pm

1 stop5h 52m

$463

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Tue 3/10

11:15 am-7:48 pm

3 stops34h 33m

$574

ColumbiaSan Diego

COU - SAN

COUSAN

Columbia Regional

Mon 3/9

2:41 pm-6:33 pm

3 stops29h 52m

$673

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/24

Sorted by cheapest first
  • Most accurate provider: When it comes to deals on Columbia, Missouri-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Columbia, Missouri-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Columbia, Missouri-San Diego flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Columbia, Missouri-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Columbia, Missouri-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Columbia to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Columbia with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated February 28, 2026.
See what other customers who have flown with United Airlines and American Airlines from Columbia to San Diego have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,363 reviews

Boarding

7.7

Comfort

7.3

Crew

8.1

Entertainment

7.1

Food

6.6

Overall

7.4

Reviews

1 / 20
10.0
Excellent

Anonymous,Sep 2025

FRA - SFO

Lufthansa was amazing, I wish United States based airlines operated like them.
United Airlines
7.4
Good
9,363 reviews
United Airlines
7.4
Good
9,363 reviews

Boarding

7.7

Comfort

7.3

Crew

8.1

Entertainment

7.1

Food

6.6

Overall

7.4

Reviews

1 / 20
10.0
Excellent

Anonymous,Sep 2025

FRA - SFO

Lufthansa was amazing, I wish United States based airlines operated like them.
American Airlines
7.2
Good
11,367 reviews
United Airlines
7.4
Good
9,363 reviews

Boarding

7.7

Comfort

7.3

Crew

8.1

Entertainment

7.1

Food

6.6

Overall

7.4

Reviews

1 / 20
10.0
Excellent

Anonymous,Sep 2025

FRA - SFO

Lufthansa was amazing, I wish United States based airlines operated like them.

Related info for your journey

Find useful and relevant information for your journey from Columbia to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Columbia, Missouri to San Diego?

    A quick flight from Columbia, Missouri to San Diego can take about 7h 55m. United Airlines provides one of the quickest options available for as low as $358. Columbia, Missouri and San Diego are separated by a distance of 1456 mi.

  • What are the cheapest airlines flying from Columbia, Missouri to San Diego round-trip?

    Our cheapest airline available from Columbia, Missouri to San Diego is United Airlines. Our recent data shows that you can find tickets from as low as $258 on this airline. An additional option worth looking into is American Airlines, starting at $429. United Airlines is currently priced 48% below the average price you’ll pay for this route.

  • Can I find deals for flights from Columbia to San Diego that include hotel bookings?

    Yes. In addition to deals on Columbia to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Columbia to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbia to San Diego.

  • Can I find deals for business class flights from Columbia to San Diego?

    Yes. Cheapflights offers flight deals from Columbia to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove

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Top 2 airlines flying from Columbia to San Diego

Discover the top 2 airlines that operate flights from Columbia to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$258Average$343FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$429Average$536FlexibilityNo cancel feeOn-time71%

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