$368+ Cheap flights from Columbia, MO to San Diego (COU - SAN)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/24. Fares are subject to change and may not be available on all flights or dates of travel.
COU — SAN
Dec 13 — Dec 201
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Columbia to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Columbia to San Diego
Cheapest
Best
Last-minute
One-way
Cheapest flights from Columbia to San DiegoExplore the most affordable flight options available from Columbia to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2026.
Explore the most affordable flight options available from Columbia to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2026.
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/246:31 pm -
1 stop6h 03m
Thu 12/311:15 pm -
1 stop5h 53m
Deal found 11/9![American Airlines logo]()
$368
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/97:48 pm -
1 stop6h 08m
Sun 12/1310:45 pm -
1 stop9h 02m
Deal found 11/12![American Airlines logo]()
$378
This United Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/99:00 am -
1 stop7h 55m
Sun 12/138:40 am -
2 stops10h 43m
Deal found 11/12![United Airlines logo]()
$408
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/107:48 pm -
1 stop6h 08m
Thu 12/177:21 am -
1 stop8h 47m
Deal found 11/12![American Airlines logo]()
$423
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:26 am -
1 stop8h 20m
Mon 11/2310:45 pm -
1 stop9h 19m
Deal found 11/9![American Airlines logo]()
$473
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/243:10 pm -
2 stops10h 41m
Thu 12/3111:25 am -
1 stop7h 04m
Deal found 11/9![United Airlines logo]()
$482
This United Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/109:00 am -
1 stop7h 55m
Thu 12/176:20 am -
2 stops12h 09m
Deal found 11/12![United Airlines logo]()
$492
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:26 am -
1 stop8h 21m
Mon 11/301:15 pm -
1 stop6h 28m
Deal found 11/10![American Airlines logo]()
$549
Best flights from Columbia to San DiegoDiscover carefully curated flight deals from Columbia to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 13, 2026.
Discover carefully curated flight deals from Columbia to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 13, 2026.
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/246:31 pm -
1 stop6h 03m
Thu 12/311:15 pm -
1 stop5h 53m
Deal found 11/9![American Airlines logo]()
$368
This United Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/87:45 am -
1 stop9h 33m
Mon 1/1111:00 am -
1 stop7h 30m
Deal found 11/12![United Airlines logo]()
$388
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/25:11 pm -
1 stop7h 45m
Tue 2/97:15 am -
1 stop7h 22m
Deal found 11/8![American Airlines logo]()
$368
This United Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/98:00 am -
2 stops8h 55m
Sun 12/138:40 am -
2 stops10h 43m
Deal found 11/12![United Airlines logo]()
$414
This United Airlines deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/167:45 am -
1 stop9h 33m
Sat 1/236:20 am -
2 stops12h 10m
Deal found 11/13![United Airlines logo]()
$423
This United Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/33:12 pm -
1 stop9h 25m
Sat 2/67:41 pm -
2 stops13h 05m
Deal found 11/10![United Airlines logo]()
$484
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/243:10 pm -
2 stops10h 41m
Thu 12/3111:25 am -
2 stops10h 02m
Deal found 11/9![United Airlines logo]()
$488
This United Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/27:45 am -
2 stops12h 43m
Tue 2/98:40 am -
2 stops12h 50m
Deal found 11/8![United Airlines logo]()
$489
Last-minute flights from Columbia to San DiegoDiscover last-minute flight deals from Columbia to San Diego. Data last updated November 13, 2026 and is based on user searches.
Discover last-minute flight deals from Columbia to San Diego. Data last updated November 13, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:26 am -
1 stop8h 20m
Mon 11/2310:45 pm -
1 stop9h 19m
Deal found 11/9![American Airlines logo]()
$473
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:26 am -
1 stop8h 21m
Mon 11/301:15 pm -
1 stop6h 28m
Deal found 11/10![American Airlines logo]()
$549
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/97:48 pm -
1 stop6h 08m
Sun 12/1310:45 pm -
1 stop9h 02m
Deal found 11/12![American Airlines logo]()
$378
This United Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/99:00 am -
1 stop7h 55m
Sun 12/138:40 am -
2 stops10h 43m
Deal found 11/12![United Airlines logo]()
$408
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/107:48 pm -
1 stop6h 08m
Thu 12/177:21 am -
1 stop8h 47m
Deal found 11/12![American Airlines logo]()
$423
This United Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/109:00 am -
1 stop7h 55m
Thu 12/176:20 am -
2 stops12h 09m
Deal found 11/12![United Airlines logo]()
$492
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/246:31 pm -
1 stop6h 03m
Thu 12/311:15 pm -
1 stop5h 53m
Deal found 11/9![American Airlines logo]()
$368
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/243:10 pm -
2 stops10h 41m
Thu 12/3111:25 am -
1 stop7h 04m
Deal found 11/9![United Airlines logo]()
$482
One-way flights from Columbia to San DiegoSearch for one-way flight options from Columbia to San Diego. Find affordable one-way fares based on user searches. Data last updated November 13, 2026.
Search for one-way flight options from Columbia to San Diego. Find affordable one-way fares based on user searches. Data last updated November 13, 2026.
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/276:28 pm -
1 stop7h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![American Airlines logo]()
$433
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/287:48 pm -
1 stop6h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![American Airlines logo]()
$553
This United Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/289:01 am -
2 stops28h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![United Airlines logo]()
$597
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/293:15 pm -
3 stops46h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![Multiple Airlines logo]()
$599
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/297:48 pm -
1 stop6h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![American Airlines logo]()
$603
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/285:25 pm -
3 stops40h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Multiple Airlines logo]()
$633
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/279:01 am -
2 stops10h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![United Airlines logo]()
$719
This United Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/299:01 am -
2 stops28h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![United Airlines logo]()
$777
Find flight deals from Columbia to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Columbia (COU) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $368 (American Airlines) |
Popular in | March |
Cheapest in | February |
Average price | $459 |
Cheapflights Fare Finder
Customize your flight search to find flights from Columbia to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 13, 2026.
Use the filters below to find and compare flights from Columbia to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Thu 12/24
6:31 pm-10:34 pm
1 stop6h 03m
San Diego
Thu 12/31
1:15 pm-9:08 pm
1 stop5h 53m
$368
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Tue 2/2
5:11 pm-10:56 pm
1 stop7h 45m
San Diego
Tue 2/9
7:15 am-4:37 pm
1 stop7h 22m
$368
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Fri 1/8
7:45 am-3:18 pm
1 stop9h 33m
San Diego
Mon 1/11
11:00 am-8:30 pm
1 stop7h 30m
$388
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Wed 12/9
8:00 am-2:55 pm
2 stops8h 55m
San Diego
Sun 12/13
8:40 am-9:23 pm
2 stops10h 43m
$414
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Sat 1/16
7:45 am-3:18 pm
1 stop9h 33m
San Diego
Sat 1/23
6:20 am-8:30 pm
2 stops12h 10m
$423
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Wed 2/3
3:12 pm-10:37 pm
1 stop9h 25m
San Diego
Sat 2/6
7:41 pm-10:46 am
2 stops13h 05m
$484
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Thu 12/24
3:10 pm-11:51 pm
2 stops10h 41m
San Diego
Thu 12/31
11:25 am-11:27 pm
2 stops10h 02m
$488
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Tue 2/2
7:45 am-6:28 pm
2 stops12h 43m
San Diego
Tue 2/9
8:40 am-11:30 pm
2 stops12h 50m
$489
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Sat 11/28
9:01 am-11:31 am
2 stops28h 30m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$597
ColumbiaSan Diego
COU Columbia Regional - SAN San Diego
COUSAN
Columbia Regional
Sun 11/29
3:15 pm-11:37 am
3 stops46h 22m
San Diego
Wed 12/31
12:00 am-2:00 am
Nonstop0h 00m
$599
Showing 1-10 of 13 resultsSorted by cheapest first
Compare providers for flights from Columbia to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Columbia to San Diego in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Columbia, Missouri-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Columbia, Missouri-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Columbia, Missouri-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Columbia, Missouri-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Columbia, Missouri-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Columbia to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Columbia with our price prediction graph.
COU-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Columbia to San Diego
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated November 13, 2026.
See what other customers who have flown with United Airlines and American Airlines from Columbia to San Diego have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.7
Overall
7.3
Comfort
7.3
Crew
8.1
Entertainment
7.1
Food
6.7
Reviews
1 / 20
4.0
OkaySimon,Jun 2024
LAS - LAX
Boarding
7.7
Overall
7.3
Comfort
7.3
Crew
8.1
Entertainment
7.1
Food
6.7
Reviews
1 / 20
4.0
OkaySimon,Jun 2024
LAS - LAX
Boarding
7.7
Overall
7.3
Comfort
7.3
Crew
8.1
Entertainment
7.1
Food
6.7
Reviews
1 / 20
4.0
OkaySimon,Jun 2024
LAS - LAX
Related info for your journey
Find useful and relevant information for your journey from Columbia to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
National City
Chula Vista
San Ysidro
Poway
Coronado
La Mesa
Julian
Santee
Lemon Grove
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Columbia
Popular flights
San Diego flight routes
Alternative routes for Columbia to San Diego
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to San Diego by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Columbia to San Diego by cabin class
Find flights from Columbia to San Diego, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Columbia and San Diego flights
Browse other Columbia and San Diego flight options. Last updated on November 13, 2026.
Other flights from Columbia
Browse through other flights departing from Columbia. Flights are based on user searches made on Cheapflights and were last updated on November 13, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Diego
Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 13, 2026.
Top 2 airlines flying from Columbia to San Diego
Discover the top 2 airlines that operate flights from Columbia to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$298 | Average$441 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$318 | Average$473 | FlexibilityNo cancel fee | On-time71% |