What are the cheapest airlines to fly from Illinois to Panama City one-way?

One-way options have recently been found by users for as low as $164 on Delta. Other airlines that offer cheap prices include Avianca from $223 and American Airlines from $268 one-way.

What are the most popular routes from Illinois to Panama City?

While some choose either Lambert-St Louis - Panama City Tocumen Intl or Evansville Dress Regional - Panama City Tocumen Intl, Chicago O'Hare Intl - Panama City Tocumen Intl is the most popular route from Illinois to Panama City.

What are the cheapest flights from Illinois to Panama City?

The cheapest flight price from Illinois to Panama City is $147. On average you can expect to pay $990. The most popular route, (Chicago O'Hare Intl - Panama City Tocumen Intl), can usually be booked for $433.

What are the most reliable airlines from Illinois to Panama City?

Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Illinois to Panama City on time: EVA Air (97%), Copa Airlines (96%), United Airlines (96%).

What are the most popular airlines that fly from Illinois to Panama City?

Before booking your flight from Illinois to Panama City check out the most popular airlines for this route: American Airlines, Avianca or Copa Airlines.

How far in advance should I book a flight from Illinois to Panama City?

Users have found that booking a flight from Illinois to Panama City at least 50 days early can save you up to 55% on average compared to booking a flight this week. If booking 50 days before your flight isn’t an option for you, users have found flights from Illinois to Panama City for as little as $481 when booking for a departure date within the next two weeks. You can also check prices now. Some users have found airline tickets as low as $759 for flights departing within the next 3 days.

What is the cheapest month to fly from Illinois to Panama City?

November can be a great time to fly to Panama City from Illinois with a flight ticket averaging about $575. Cheapflights users have found deals in the month of November for as cheap as $432. The most expensive prices can be found in the month of December.

What airport do you fly into for flights to Panama City from Illinois?

Panama City Tocumen Intl (PTY), located 11.4 mi from the city center, is the airport you fly into when you book flights from Illinois to Panama City.

Can I find deals for flights from Illinois to Panama City that include hotel bookings?

Yes. In addition to deals on Illinois to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Illinois to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Illinois to Panama City.

Can I find deals for business class flights from Illinois to Panama City?

Yes. Cheapflights offers flight deals from Illinois to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$164+ Flights from Illinois to Panama City

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Cheap flight deals from Illinois to Panama City

Round-trip from	$393 (United Airlines)
One-way from	$164 (Delta)
Popular in	December
Cheapest in	November
Average price	$528
Good round-trip deal	$464 or less
Good one-way deal	$216 or less

From Illinois to Panama City Tocumen Intl

Search Deals

One-way flight from Illinois to Panama City Tocumen Intl

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Highest demand for flights based on searches. 6% potential increase in price ($43 potential increase over avg. RT price).

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Cheapest flight prices on average. 3% potential price decrease ($17 potential savings vs. average RT price).

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Average for round-trip flights in June 2025

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Price to beat on a round-trip flight from Illinois to Panama City Tocumen Intl.

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Price to beat on a one-way flight from Illinois to Panama City Tocumen Intl.

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Find flight deals from Illinois to Panama City

Cheapest flights from Illinois to Panama City
Explore the most affordable flight options available from Illinois to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Mon 8/258:20 amSTL - PTY

1 stop10h 17mUnited Airlines

Tue 9/23:30 pmPTY - STL

1 stop18h 31mUnited Airlines

Deal found 6/10

$393

Mon 7/281:29 pmSTL - PTY

1 stop23h 44mDelta

Wed 8/62:28 pmPTY - STL

1 stop17h 54mDelta

Deal found 6/11

$401

Sat 9/205:05 amORD - PTY

3 stops29h 20mMultiple Airlines

Wed 9/2410:05 pmPTY - ORD

2 stops22h 35mMultiple Airlines

Deal found 6/12

$467

Thu 10/305:08 pmEVV - PTY

2 stops19h 17mAmerican Airlines

Wed 11/54:20 pmPTY - EVV

2 stops23h 02mAmerican Airlines

Deal found 6/12

$475

Thu 7/318:01 pmSTL - PTY

2 stops18h 14mAmerican Airlines

Fri 8/83:30 pmPTY - STL

2 stops40h 36mAmerican Airlines

Deal found 6/11

$476

Thu 10/92:35 pmORD - PTY

1 stop9h 35mAvianca

Wed 10/153:20 amPTY - ORD

1 stop9h 55mAvianca

Deal found 6/10

$481

Fri 9/123:07 pmORD - PTY

Nonstop5h 28mCopa Airlines

Fri 9/196:45 pmPTY - ORD

Nonstop5h 37mCopa Airlines

Deal found 6/10

$569

Thu 7/317:10 amORD - PTY

1 stop11h 27mUnited Airlines

Mon 8/43:30 pmPTY - ORD

1 stop8h 45mUnited Airlines

Deal found 6/11

$583

Fri 9/128:47 pmORD - PTY

2 stops17h 44mAmerican Airlines

Sun 9/213:34 pmPTY - ORD

2 stops15h 51mAmerican Airlines

Deal found 6/11

$588

Tue 7/85:20 pmMDW - PTY

3 stops23h 10mMultiple Airlines

Mon 7/143:25 amPTY - MDW

3 stops29h 20mMultiple Airlines

Deal found 6/10

$604

Wed 7/3011:24 amSTL - PTY

3 stops36h 46mMultiple Airlines

Wed 8/611:05 amPTY - STL

3 stops29h 26mMultiple Airlines

Deal found 6/11

$615

Thu 10/306:00 amEVV - PTY

1 stop6h 47mDelta

Wed 11/53:12 pmPTY - EVV

1 stop7h 51mDelta

Deal found 6/10

$633

Best flights from Illinois to Panama City
Discover carefully curated flight deals from Illinois to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 12, 2025.

Mon 8/256:15 amSTL - PTY

1 stop12h 22mUnited Airlines

Mon 9/83:30 pmPTY - STL

1 stop18h 31mUnited Airlines

Deal found 6/10

$393

Mon 7/281:29 pmSTL - PTY

1 stop23h 44mDelta

Wed 8/62:28 pmPTY - STL

1 stop17h 54mDelta

Deal found 6/11

$401

Sat 9/205:05 amORD - PTY

3 stops29h 20mMultiple Airlines

Wed 9/2410:05 pmPTY - ORD

2 stops22h 35mMultiple Airlines

Deal found 6/12

$467

Thu 7/318:01 pmSTL - PTY

2 stops18h 14mAmerican Airlines

Fri 8/83:30 pmPTY - STL

2 stops40h 36mAmerican Airlines

Deal found 6/11

$476

Thu 10/92:35 pmORD - PTY

1 stop9h 35mAvianca

Wed 10/153:20 amPTY - ORD

1 stop9h 55mAvianca

Deal found 6/10

$481

Wed 8/67:54 amORD - PTY

Nonstop5h 28mCopa Airlines

Sun 8/106:45 pmPTY - ORD

Nonstop5h 37mCopa Airlines

Deal found 6/10

$569

Thu 7/314:31 pmEVV - PTY

2 stops21h 44mAmerican Airlines

Tue 8/51:55 pmPTY - EVV

2 stops26h 49mAmerican Airlines

Deal found 6/11

$544

Thu 7/316:00 amORD - PTY

1 stop10h 12mUnited Airlines

Sun 8/310:00 amPTY - ORD

1 stop14h 15mUnited Airlines

Deal found 6/11

$583

Tue 7/85:20 pmMDW - PTY

3 stops23h 10mMultiple Airlines

Mon 7/143:25 amPTY - MDW

3 stops29h 20mMultiple Airlines

Deal found 6/10

$604

Fri 9/128:29 pmORD - PTY

2 stops18h 02mAmerican Airlines

Sun 9/213:34 pmPTY - ORD

2 stops16h 08mAmerican Airlines

Deal found 6/12

$588

Wed 7/3011:24 amSTL - PTY

3 stops36h 46mMultiple Airlines

Wed 8/611:05 amPTY - STL

3 stops29h 26mMultiple Airlines

Deal found 6/11

$615

Thu 7/316:00 amMDW - PTY

1 stop7h 13mDelta

Wed 8/62:28 pmPTY - MDW

2 stops18h 16mDelta

Deal found 6/11

$685

Last-minute flights from Illinois to Panama City
Discover last-minute flight deals from Illinois to Panama City. Data last updated June 12, 2025 and is based on user searches.

Tue 6/179:40 amMDW - PTY

3 stops24h 30mMultiple Airlines

Tue 6/243:40 pmPTY - MDW

2 stops17h 05mMultiple Airlines

Deal found 6/10

$776

Wed 6/188:25 amSTL - PTY

1 stop7h 47mUnited Airlines

Wed 6/253:30 pmPTY - STL

1 stop18h 01mUnited Airlines

Deal found 6/11

$590

Fri 6/207:10 amORD - PTY

1 stop11h 27mUnited Airlines

Tue 6/2410:55 pmPTY - ORD

1 stop9h 44mUnited Airlines

Deal found 6/9

$983

Fri 6/206:00 amMDW - PTY

1 stop7h 08mDelta

Sun 6/228:10 amPTY - MDW

1 stop13h 35mDelta

Deal found 6/9

$1,063

Sat 6/215:25 pmORD - PTY

1 stop17h 00mMultiple Airlines

Wed 6/253:40 pmPTY - ORD

2 stops32h 05mMultiple Airlines

Deal found 6/9

$565

Sat 6/215:25 pmORD - PTY

1 stop17h 00mAvianca

Mon 6/233:25 amPTY - ORD

2 stops15h 25mAvianca

Deal found 6/9

$666

Sat 6/213:07 pmORD - PTY

Nonstop5h 28mCopa Airlines

Wed 6/256:45 pmPTY - ORD

Nonstop5h 49mCopa Airlines

Deal found 6/9

$969

Sun 6/225:35 amORD - PTY

1 stop7h 33mDelta

Tue 6/242:23 pmPTY - ORD

1 stop9h 34mDelta

Deal found 6/9

$1,063

Thu 7/35:59 pmEVV - PTY

1 stop25h 03mKLM

Thu 7/102:28 pmPTY - EVV

1 stop7h 24mKLM

Deal found 6/12

$789

Tue 7/85:20 pmMDW - PTY

3 stops23h 10mMultiple Airlines

Mon 7/143:25 amPTY - MDW

3 stops29h 20mMultiple Airlines

Deal found 6/10

$604

Mon 7/214:28 pmSTL - PTY

2 stops20h 26mAmerican Airlines

Fri 7/251:55 pmPTY - STL

2 stops18h 18mAmerican Airlines

Deal found 6/9

$398

Tue 7/225:05 amORD - PTY

1 stop15h 14mMultiple Airlines

Tue 7/2912:03 pmPTY - ORD

1 stop11h 10mMultiple Airlines

Deal found 6/11

$475

One-way flights from Illinois to Panama City
Search for one-way flight options from Illinois to Panama City. Find affordable one-way fares based on user searches. Data last updated June 12, 2025.

Mon 8/256:00 amSTL - PTY

1 stop6h 50mDelta

Deal found 6/10

$164

Sun 7/278:09 amORD - PTY

2 stops30h 31mMultiple Airlines

Deal found 6/11

$192

Mon 9/292:35 pmORD - PTY

1 stop10h 10mAvianca

Deal found 6/12

$223

Fri 8/299:17 amMDW - PTY

2 stops11h 53mMultiple Airlines

Deal found 6/12

$249

Mon 6/304:31 pmEVV - PTY

2 stops20h 29mAmerican Airlines

Deal found 6/11

$268

Mon 6/238:25 amSTL - PTY

1 stop10h 12mUnited Airlines

Deal found 6/11

$273

Mon 6/2311:28 amSTL - PTY

3 stops36h 42mMultiple Airlines

Deal found 6/11

$329

Sun 7/279:07 pmORD - PTY

1 stop17h 07mUnited Airlines

Deal found 6/12

$579

Wed 7/166:20 amEVV - PTY

1 stop6h 53mDelta

Deal found 6/10

$636

Tue 7/297:54 amORD - PTY

Nonstop5h 28mCopa Airlines

Deal found 6/10

$645

Wed 8/276:00 amMDW - PTY

1 stop6h 50mDelta

Deal found 6/12

$824

Sat 7/262:01 amORD - PTY

1 stop11h 46mAeromexico

Deal found 6/11

$932

Cheapflights Fare Finder

Use the filters below to find and compare flights from Illinois to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 8/25

6:15 am-6:37 pm

1 stop12h 22m

Panama City Tocumen Intl

Mon 9/8

3:30 pm-10:01 am

1 stop18h 31m

$393

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Mon 7/28

1:29 pm-1:13 pm

1 stop23h 44m

Panama City Tocumen Intl

Wed 8/6

2:28 pm-8:22 am

1 stop17h 54m

$401

EvansvillePanama City

EVV - PTY

EVVPTY

Evansville Dress Regional

Thu 10/30

11:08 am-12:25 pm

2 stops25h 17m

Panama City Tocumen Intl

Wed 11/5

4:20 pm-10:25 am

2 stops19h 05m

$475

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Tue 7/22

5:05 am-8:19 pm

1 stop15h 14m

Panama City Tocumen Intl

Tue 7/29

12:03 pm-11:13 pm

1 stop11h 10m

$475

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 7/31

8:01 pm-2:15 pm

2 stops18h 14m

Panama City Tocumen Intl

Fri 8/8

3:30 pm-8:06 am

2 stops40h 36m

$476

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Fri 8/22

2:35 pm-8:55 am

1 stop18h 20m

Panama City Tocumen Intl

Wed 8/27

3:20 am-1:15 pm

1 stop9h 55m

$505

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Wed 8/6

7:54 am-1:22 pm

Nonstop5h 28m

Panama City Tocumen Intl

Sun 8/10

6:45 pm-12:22 am

Nonstop5h 37m

$569

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Thu 7/31

7:10 am-6:37 pm

1 stop11h 27m

Panama City Tocumen Intl

Mon 8/4

3:30 pm-12:15 am

1 stop8h 45m

$583

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Tue 7/8

5:20 pm-4:30 pm

3 stops23h 10m

Panama City Tocumen Intl

Mon 7/14

3:25 am-8:45 am

3 stops29h 20m

$604

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 7/30

11:24 am-12:10 am

3 stops36h 46m

Panama City Tocumen Intl

Wed 8/6

11:05 am-4:31 pm

3 stops29h 26m

$615

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Showing 1-10 of 30 results

Best time to book a flight from Illinois to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Illinois with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Illinois to Panama City

What is the cheapest month to book a flight from Illinois to Panama City?

Currently, October is the cheapest month in which you can book a flight from Illinois to Panama City (average of $478). Flying from Illinois to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IL to PTY?

When flying from Illinois to Panama City, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Panama City by month

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

Temperature in Panama City by month

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama City

Peruse reviews from past customers who have flown with Delta, Copa Airlines and Aeromexico from Illinois to Panama City to help guide your decision. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,950 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Copa Airlines

7.5

Good

1,451 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Aeromexico

7.5

Good

1,706 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,790 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,950 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What airport do you fly into for flights to Panama City from Illinois?
Panama City Tocumen Intl (PTY), located 11.4 mi from the city center, is the airport you fly into when you book flights from Illinois to Panama City.
What are the cheapest airlines to fly from Illinois to Panama City one-way?
One-way options have recently been found by users for as low as $164 on Delta. Other airlines that offer cheap prices include Avianca from $223 and American Airlines from $268 one-way.
What are the most popular routes from Illinois to Panama City?
While some choose either Lambert-St Louis - Panama City Tocumen Intl or Evansville Dress Regional - Panama City Tocumen Intl, Chicago O'Hare Intl - Panama City Tocumen Intl is the most popular route from Illinois to Panama City.
What are the most reliable airlines from Illinois to Panama City?
Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Illinois to Panama City on time: EVA Air (97%), Copa Airlines (96%), United Airlines (96%).
What are the cheapest flights from Illinois to Panama City?
The cheapest flight price from Illinois to Panama City is $147. On average you can expect to pay $990. The most popular route, (Chicago O'Hare Intl - Panama City Tocumen Intl), can usually be booked for $433.
Can I find deals for flights from Illinois to Panama City that include hotel bookings?
Yes. In addition to deals on Illinois to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Illinois to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Illinois to Panama City.
Can I find deals for business class flights from Illinois to Panama City?
Yes. Cheapflights offers flight deals from Illinois to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Illinois to Panama City?
Currently, October is the cheapest month in which you can book a flight from Illinois to Panama City (average of $478). Flying from Illinois to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 5 airlines flying from Illinois to Panama City

Airline	Cheapest	Average	Flexibility	On-time
Avianca	Cheapest$339	Average$451	FlexibilityNo cancel fee	On-time71%
Copa Airlines	Cheapest$464	Average$578	FlexibilityNo cancel fee	On-time70%
American Airlines	Cheapest$478	Average$707	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$478	Average$643	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$478	Average$615	FlexibilityNo cancel fee	On-time69%

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$164+ Cheap flights from Illinois to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/25. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Illinois to Panama City with Cheapflights

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Cheap flight deals from Illinois to Panama City

Keep the following information in mind while searching for Illinois to Panama City flight deals. Data was last updated June 12, 2025.

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from Illinois to Panama City

Cheapest flights from Illinois to Panama CityExplore the most affordable flight options available from Illinois to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Explore the most affordable flight options available from Illinois to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Illinois to Panama City that are best for you.

Best time to book a flight from Illinois to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Illinois with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Illinois to Panama City

What is the cheapest month to book a flight from Illinois to Panama City?

What is the cheapest time of day to fly from IL to PTY?

Find hourly flight availability from Illinois to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

Reviews of airlines servicing Panama City

Peruse reviews from past customers who have flown with Delta, Copa Airlines and Aeromexico from Illinois to Panama City to help guide your decision. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Illinois to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Panama City from Illinois?

What are the cheapest airlines to fly from Illinois to Panama City one-way?

What are the most popular routes from Illinois to Panama City?

What are the most reliable airlines from Illinois to Panama City?

What are the cheapest flights from Illinois to Panama City?

Can I find deals for flights from Illinois to Panama City that include hotel bookings?

How can I find direct flights from Illinois to Panama City?

Can I find deals for business class flights from Illinois to Panama City?

What is the cheapest month to book a flight from Illinois to Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Illinois to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 5 airlines flying from Illinois to Panama City

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Cheapest flights from Illinois to Panama City
Explore the most affordable flight options available from Illinois to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.