What are the cheapest airlines to fly from Illinois to Panama City one-way?

One-way options have recently been found by users for as low as $154 on United Airlines. Other airlines that offer cheap prices include Avianca from $167 and Delta from $167 one-way.

What are the most popular routes from Illinois to Panama City?

While some choose either Chicago Midway - Panama City Tocumen Intl or Lambert-St Louis - Panama City Tocumen Intl, Chicago O'Hare Intl - Panama City Tocumen Intl is the most popular route from Illinois to Panama City.

What are the cheapest flights from Illinois to Panama City?

The cheapest flight price from Illinois to Panama City is $130. On average you can expect to pay $855. The most popular route, (Chicago O'Hare Intl - Panama City Tocumen Intl), can usually be booked for $386.

What are the most reliable airlines from Illinois to Panama City?

Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Illinois to Panama City on time: Copa Airlines (94%), United Airlines (94%), EVA Air (93%).

What are the most popular airlines that fly from Illinois to Panama City?

Before booking your flight from Illinois to Panama City check out the most popular airlines for this route: American Airlines, Avianca or Copa Airlines.

How far in advance should I book a flight from Illinois to Panama City?

Users have found that booking a flight from Illinois to Panama City at least 50 days early can save you up to 14% on average compared to booking a flight this week. If booking 50 days before your flight isn’t an option for you, users have found flights from Illinois to Panama City for as little as $481 when booking for a departure date within the next two weeks. You can also check prices now. Some users have found airline tickets as low as $531 for flights departing within the next 3 days.

What is the cheapest month to fly from Illinois to Panama City?

November can be a great time to fly to Panama City from Illinois with a flight ticket averaging about $569. Cheapflights users have found deals in the month of November for as cheap as $432. The most expensive prices can be found in the month of December.

What airport do you fly into for flights to Panama City from Illinois?

Panama City Tocumen Intl (PTY), located 11.4 mi from the city center, is the airport you fly into when you book flights from Illinois to Panama City.

Can I find deals for flights from Illinois to Panama City that include hotel bookings?

Yes. In addition to deals on Illinois to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Illinois to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Illinois to Panama City.

Can I find deals for business class flights from Illinois to Panama City?

Yes. Cheapflights offers flight deals from Illinois to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$154+ Flights from Illinois to Panama City

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Cheap flight deals from Illinois to Panama City

Most accurate provider	AranGrant 3 stars
Most trusted provider	AranGrant 3 stars
Round-trip from	$398 (United Airlines)
One-way from	$154 (United Airlines)
Popular in	December
Cheapest in	November
Average price	$517
Good round-trip deal	$465 or less
Good one-way deal	$200 or less

Provider with most accurate pricing for Chicago (CHI)-Panama City Tocumen Intl flight deals.

Search Deals

Provider most trusted by Cheapflights users for Chicago (CHI)-Panama City Tocumen Intl flights.

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From Illinois to Panama City Tocumen Intl

Search Deals

One-way flight from Illinois to Panama City Tocumen Intl

Search Deals

Highest demand for flights based on searches. 8% potential increase in price ($49 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 3% potential price decrease ($18 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in May 2025

Search Deals

Price to beat on a round-trip flight from Illinois to Panama City Tocumen Intl.

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Price to beat on a one-way flight from Illinois to Panama City Tocumen Intl.

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Find flight deals from Illinois to Panama City

Cheapest flights from Illinois to Panama City
Explore the most affordable flight options available from Illinois to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

Thu 6/2610:15 amSTL - PTY

1 stop27h 59mUnited Airlines

Mon 6/303:30 pmPTY - STL

1 stop18h 01mUnited Airlines

Deal found 4/29

$398

Sat 6/1410:05 amSTL - PTY

1 stop8h 57mDelta

Sat 6/218:10 amPTY - STL

1 stop8h 15mDelta

Deal found 4/30

$407

Thu 6/265:47 pmSTL - PTY

2 stops19h 13mAmerican Airlines

Mon 6/301:50 pmPTY - STL

2 stops18h 56mAmerican Airlines

Deal found 4/29

$443

Mon 6/97:54 amORD - PTY

Nonstop5h 28mCopa Airlines

Mon 6/166:45 pmPTY - ORD

Nonstop5h 49mCopa Airlines

Deal found 4/30

$465

Sun 11/301:35 pmORD - PTY

1 stop9h 45mAvianca

Sat 12/63:19 amPTY - ORD

1 stop33h 56mAvianca

Deal found 4/30

$467

Fri 5/302:35 pmORD - PTY

1 stop9h 35mMultiple Airlines

Sun 6/19:21 pmPTY - ORD

2 stops35h 29mMultiple Airlines

Deal found 4/30

$470

Wed 5/285:30 amORD - PTY

1 stop7h 18mDelta

Tue 6/32:13 pmPTY - ORD

1 stop18h 16mDelta

Deal found 4/30

$479

Wed 5/286:00 amMDW - PTY

1 stop6h 48mDelta

Sun 6/18:00 amPTY - MDW

1 stop9h 36mDelta

Deal found 4/30

$479

Fri 5/239:40 pmORD - PTY

1 stop20h 57mUnited Airlines

Wed 5/2810:00 amPTY - ORD

1 stop14h 13mUnited Airlines

Deal found 4/30

$489

Thu 7/34:31 pmEVV - PTY

2 stops21h 54mAmerican Airlines

Thu 7/101:55 pmPTY - EVV

2 stops22h 32mAmerican Airlines

Deal found 4/30

$507

Sat 10/118:37 pmORD - PTY

2 stops15h 48mAmerican Airlines

Mon 10/131:50 pmPTY - ORD

1 stop8h 44mAmerican Airlines

Deal found 4/30

$571

Sun 6/16:20 amMDW - PTY

1 stop13h 13mMultiple Airlines

Tue 6/39:25 amPTY - MDW

1 stop13h 19mMultiple Airlines

Deal found 4/30

$571

Best flights from Illinois to Panama City
Discover carefully curated flight deals from Illinois to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 1, 2025.

Thu 6/2610:15 amSTL - PTY

1 stop27h 59mUnited Airlines

Mon 6/303:30 pmPTY - STL

1 stop18h 01mUnited Airlines

Deal found 4/29

$398

Sat 6/1410:05 amSTL - PTY

1 stop8h 57mDelta

Sat 6/218:10 amPTY - STL

1 stop8h 15mDelta

Deal found 4/30

$407

Thu 6/265:47 pmSTL - PTY

2 stops19h 13mAmerican Airlines

Mon 6/301:50 pmPTY - STL

2 stops18h 56mAmerican Airlines

Deal found 4/29

$443

Mon 6/97:54 amORD - PTY

Nonstop5h 28mCopa Airlines

Mon 6/166:45 pmPTY - ORD

Nonstop5h 49mCopa Airlines

Deal found 4/30

$465

Sun 6/153:45 pmORD - PTY

2 stops18h 40mAvianca

Fri 6/203:40 pmPTY - ORD

2 stops21h 35mAvianca

Deal found 4/29

$469

Fri 5/302:35 pmORD - PTY

1 stop9h 35mMultiple Airlines

Sun 6/19:21 pmPTY - ORD

2 stops35h 29mMultiple Airlines

Deal found 4/30

$470

Wed 5/285:30 amORD - PTY

1 stop7h 18mDelta

Tue 6/32:13 pmPTY - ORD

1 stop18h 16mDelta

Deal found 4/30

$479

Fri 5/239:40 pmORD - PTY

1 stop20h 57mUnited Airlines

Wed 5/2810:00 amPTY - ORD

1 stop14h 13mUnited Airlines

Deal found 4/30

$489

Thu 7/34:31 pmEVV - PTY

2 stops21h 54mAmerican Airlines

Thu 7/101:55 pmPTY - EVV

2 stops22h 32mAmerican Airlines

Deal found 4/30

$507

Wed 5/286:00 amMDW - PTY

1 stop6h 48mDelta

Sun 6/18:00 amPTY - MDW

1 stop9h 36mDelta

Deal found 4/30

$479

Sun 6/16:20 amMDW - PTY

1 stop13h 13mMultiple Airlines

Tue 6/39:25 amPTY - MDW

1 stop13h 19mMultiple Airlines

Deal found 4/30

$571

Sat 10/118:37 pmORD - PTY

2 stops15h 48mAmerican Airlines

Mon 10/131:50 pmPTY - ORD

1 stop8h 44mAmerican Airlines

Deal found 4/30

$571

Last-minute flights from Illinois to Panama City
Discover last-minute flight deals from Illinois to Panama City. Data last updated May 1, 2025 and is based on user searches.

Thu 5/12:35 pmORD - PTY

1 stop19h 35mAvianca

Fri 5/910:05 pmPTY - ORD

1 stop15h 10mAvianca

Deal found 4/30

$467

Fri 5/25:35 amSTL - PTY

1 stop6h 40mAmerican Airlines

Tue 5/61:20 pmPTY - STL

1 stop8h 59mAmerican Airlines

Deal found 4/30

$591

Tue 5/68:30 amSTL - PTY

1 stop7h 42mUnited Airlines

Thu 7/1010:00 amPTY - STL

1 stop12h 15mUnited Airlines

Deal found 4/30

$482

Tue 5/68:25 amSTL - PTY

2 stops15h 45mAvianca

Wed 7/93:20 amPTY - STL

2 stops30h 39mAvianca

Deal found 4/30

$1,060

Wed 5/76:00 amSTL - PTY

1 stop6h 48mDelta

Sun 5/112:13 pmPTY - STL

1 stop9h 25mDelta

Deal found 4/30

$611

Thu 5/87:54 amORD - PTY

Nonstop5h 28mCopa Airlines

Thu 5/86:45 pmPTY - ORD

Nonstop5h 49mCopa Airlines

Deal found 4/30

$465

Thu 5/86:00 amORD - PTY

1 stop13h 33mMultiple Airlines

Thu 5/810:05 pmPTY - ORD

2 stops19h 36mMultiple Airlines

Deal found 4/30

$595

Fri 5/95:15 amORD - PTY

1 stop8h 59mUnited Airlines

Fri 5/167:55 amPTY - ORD

1 stop16h 20mUnited Airlines

Deal found 4/30

$479

Sat 5/1012:48 pmMDW - PTY

1 stop7h 05mDelta

Sat 5/178:00 amPTY - MDW

1 stop7h 30mDelta

Deal found 4/30

$479

Sat 5/107:10 amORD - PTY

2 stops12h 43mDelta

Sat 5/178:00 amPTY - ORD

2 stops13h 00mDelta

Deal found 4/30

$484

Sun 5/112:35 pmORD - PTY

1 stop9h 35mAvianca

Wed 5/143:20 amPTY - ORD

1 stop9h 55mAvianca

Deal found 4/30

$587

Sun 5/116:00 pmSTL - PTY

2 stops18h 19mAmerican Airlines

Sun 5/181:20 pmPTY - STL

2 stops20h 22mAmerican Airlines

Deal found 4/30

$615

One-way flights from Illinois to Panama City
Search for one-way flight options from Illinois to Panama City. Find affordable one-way fares based on user searches. Data last updated May 1, 2025.

Tue 6/35:00 amSTL - PTY

2 stops13h 37mUnited Airlines

Deal found 4/30

$154

Fri 6/203:45 pmORD - PTY

2 stops23h 00mAvianca

Deal found 4/30

$167

Sun 6/13:45 pmSTL - PTY

1 stop21h 03mDelta

Deal found 4/30

$167

Sun 6/16:00 pmSTL - PTY

2 stops18h 19mAmerican Airlines

Deal found 4/30

$177

Sat 5/241:02 pmORD - PTY

2 stops32h 08mMultiple Airlines

Deal found 4/30

$195

Thu 5/2910:10 amSTL - PTY

3 stops24h 22mMultiple Airlines

Deal found 4/30

$211

Mon 6/301:00 pmEVV - PTY

2 stops24h 00mAmerican Airlines

Deal found 4/30

$238

Tue 10/286:00 amEVV - PTY

1 stop6h 47mDelta

Deal found 4/30

$274

Tue 5/69:34 amMDW - PTY

3 stops31h 18mMultiple Airlines

Deal found 4/30

$319

Sun 6/159:40 pmORD - PTY

1 stop18h 32mUnited Airlines

Deal found 4/30

$365

Fri 5/303:07 pmORD - PTY

Nonstop5h 28mCopa Airlines

Deal found 4/30

$533

Fri 6/209:24 amMDW - PTY

2 stops10h 06mDelta

Deal found 4/30

$818

Cheapflights Fare Finder

Use the filters below to find and compare flights from Illinois to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 6/26

10:15 am-2:14 pm

1 stop27h 59m

Panama City Tocumen Intl

Mon 6/30

3:30 pm-9:31 am

1 stop18h 01m

$398

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Sat 6/14

10:05 am-7:02 pm

1 stop8h 57m

Panama City Tocumen Intl

Sat 6/21

8:10 am-4:25 pm

1 stop8h 15m

$407

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 6/26

5:47 pm-1:00 pm

2 stops19h 13m

Panama City Tocumen Intl

Mon 6/30

1:50 pm-8:46 am

2 stops18h 56m

$443

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Mon 6/9

7:54 am-1:22 pm

Nonstop5h 28m

Panama City Tocumen Intl

Mon 6/16

6:45 pm-12:34 am

Nonstop5h 49m

$465

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Sun 6/15

3:45 pm-10:25 am

2 stops18h 40m

Panama City Tocumen Intl

Fri 6/20

3:40 pm-1:15 pm

2 stops21h 35m

$469

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Fri 5/30

2:35 pm-12:10 am

1 stop9h 35m

Panama City Tocumen Intl

Sun 6/1

9:21 pm-8:50 am

2 stops35h 29m

$470

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Wed 5/28

5:30 am-12:48 pm

1 stop7h 18m

Panama City Tocumen Intl

Tue 6/3

2:13 pm-8:29 am

1 stop18h 16m

$479

ChicagoPanama City

MDW - PTY

MDWPTY

Chicago Midway

Wed 5/28

6:00 am-12:48 pm

1 stop6h 48m

Panama City Tocumen Intl

Sun 6/1

8:00 am-5:36 pm

1 stop9h 36m

$479

ChicagoPanama City

ORD - PTY

ORDPTY

Chicago O'Hare Intl

Fri 5/23

9:40 pm-6:37 pm

1 stop20h 57m

Panama City Tocumen Intl

Wed 5/28

10:00 am-12:13 am

1 stop14h 13m

$489

EvansvillePanama City

EVV - PTY

EVVPTY

Evansville Dress Regional

Thu 7/3

4:31 pm-2:25 pm

2 stops21h 54m

Panama City Tocumen Intl

Thu 7/10

1:55 pm-12:27 pm

2 stops22h 32m

$507

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Showing 1-10 of 29 results

Best time to book a flight from Illinois to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Illinois with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Illinois to Panama City

What is the cheapest month to book a flight from Illinois to Panama City?

Currently, October is the cheapest month in which you can book a flight from Illinois to Panama City (average of $478). Flying from Illinois to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IL to PTY?

When flying from Illinois to Panama City, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in Panama City by month

In terms of precipitation, rainfall in Panama City ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama City when rainfall is around 0.4 in.

Temperature in Panama City by month

If weather is an important factor for your trip to Panama City, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama City

Peruse reviews from past customers who have flown with Delta, Copa Airlines and Aeromexico from Illinois to Panama City to help guide your decision. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,934 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Delta

8.0

Very good

7,934 reviews

Delta

8.0

Very good

7,934 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Copa Airlines

7.5

Good

1,414 reviews

Delta

8.0

Very good

7,934 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Aeromexico

7.5

Good

1,698 reviews

Delta

8.0

Very good

7,934 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

United Airlines

7.4

Good

8,696 reviews

Delta

8.0

Very good

7,934 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Turkish Airlines

7.3

Good

3,790 reviews

Delta

8.0

Very good

7,934 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

What airport do you fly into for flights to Panama City from Illinois?
Panama City Tocumen Intl (PTY), located 11.4 mi from the city center, is the airport you fly into when you book flights from Illinois to Panama City.
What are the cheapest airlines to fly from Illinois to Panama City one-way?
One-way options have recently been found by users for as low as $154 on United Airlines. Other airlines that offer cheap prices include Avianca from $167 and Delta from $167 one-way.
What are the most popular routes from Illinois to Panama City?
While some choose either Chicago Midway - Panama City Tocumen Intl or Lambert-St Louis - Panama City Tocumen Intl, Chicago O'Hare Intl - Panama City Tocumen Intl is the most popular route from Illinois to Panama City.
What are the most reliable airlines from Illinois to Panama City?
Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Illinois to Panama City on time: Copa Airlines (94%), United Airlines (94%), EVA Air (93%).
What are the cheapest flights from Illinois to Panama City?
The cheapest flight price from Illinois to Panama City is $130. On average you can expect to pay $855. The most popular route, (Chicago O'Hare Intl - Panama City Tocumen Intl), can usually be booked for $386.
Can I find deals for flights from Illinois to Panama City that include hotel bookings?
Yes. In addition to deals on Illinois to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Illinois to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Illinois to Panama City.
Can I find deals for business class flights from Illinois to Panama City?
Yes. Cheapflights offers flight deals from Illinois to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Illinois to Panama City?
Currently, October is the cheapest month in which you can book a flight from Illinois to Panama City (average of $478). Flying from Illinois to Panama City in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 5 airlines flying from Illinois to Panama City

Airline	Cheapest	Average	Flexibility	On-time
Avianca	Cheapest$339	Average$450	FlexibilityNo cancel fee	On-time71%
Copa Airlines	Cheapest$464	Average$583	FlexibilityNo cancel fee	On-time70%
American Airlines	Cheapest$478	Average$632	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$478	Average$646	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$478	Average$636	FlexibilityNo cancel fee	On-time69%

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$154+ Cheap flights from Illinois to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/3. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Illinois to Panama City with Cheapflights

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Cheap flight deals from Illinois to Panama City

Keep the following information in mind while searching for Illinois to Panama City flight deals. Data was last updated May 1, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from Illinois to Panama City

Cheapest flights from Illinois to Panama CityExplore the most affordable flight options available from Illinois to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

Explore the most affordable flight options available from Illinois to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Illinois to Panama City that are best for you.

Best time to book a flight from Illinois to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Illinois with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Illinois to Panama City

What is the cheapest month to book a flight from Illinois to Panama City?

What is the cheapest time of day to fly from IL to PTY?

Find hourly flight availability from Illinois to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

Reviews of airlines servicing Panama City

Peruse reviews from past customers who have flown with Delta, Copa Airlines and Aeromexico from Illinois to Panama City to help guide your decision. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Illinois to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Panama City from Illinois?

What are the cheapest airlines to fly from Illinois to Panama City one-way?

What are the most popular routes from Illinois to Panama City?

What are the most reliable airlines from Illinois to Panama City?

What are the cheapest flights from Illinois to Panama City?

Can I find deals for flights from Illinois to Panama City that include hotel bookings?

How can I find direct flights from Illinois to Panama City?

Can I find deals for business class flights from Illinois to Panama City?

What is the cheapest month to book a flight from Illinois to Panama City?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Illinois to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 5 airlines flying from Illinois to Panama City

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Cheapest flights from Illinois to Panama City
Explore the most affordable flight options available from Illinois to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.