$252+ Cheap flights from Detroit (DTT) to Panama City (PTY)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/9. Fares are subject to change and may not be available on all flights or dates of travel.
DTT — PTY
Oct 16 — Oct 231
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Detroit to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Detroit to Panama City
Cheapest
Best
Last-minute
One-way
Cheapest flights from Detroit to Panama CityExplore the most affordable flight options available from Detroit to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2026.
Explore the most affordable flight options available from Detroit to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:25 am -
1 stop15h 06m
Sun 11/159:31 pm -
2 stops51h 13m
Deal found 9/12![Multiple Airlines logo]()
$669
This FlightHub deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:30 pm -
2 stops18h 00m
Tue 10/203:50 pm -
2 stops23h 59m
Deal found 9/11![Multiple Airlines logo]()
$689
This FlightHub deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:36 am -
2 stops19h 34m
Fri 12/115:30 am -
2 stops18h 26m
Deal found 9/15![Multiple Airlines logo]()
$690
This Justfly.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:30 pm -
2 stops18h 00m
Sun 10/43:50 pm -
2 stops23h 50m
Deal found 9/14![Multiple Airlines logo]()
$698
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:00 am -
1 stop8h 13m
Fri 12/113:13 pm -
1 stop8h 41m
Deal found 9/15![American Airlines logo]()
$709
This Expedia deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:30 pm -
2 stops18h 00m
Tue 10/63:50 pm -
2 stops23h 50m
Deal found 9/13![Multiple Airlines logo]()
$712
This Expedia deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:39 pm -
2 stops33h 16m
Tue 10/203:50 pm -
2 stops23h 59m
Deal found 9/14![Multiple Airlines logo]()
$729
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:30 am -
1 stop15h 01m
Mon 10/199:33 pm -
2 stops13h 23m
Deal found 9/14![Multiple Airlines logo]()
$736
Best flights from Detroit to Panama CityDiscover carefully curated flight deals from Detroit to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 16, 2026.
Discover carefully curated flight deals from Detroit to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 16, 2026.
This FlightHub deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:30 pm -
2 stops18h 00m
Sun 10/43:50 pm -
2 stops23h 50m
Deal found 9/15![Multiple Airlines logo]()
$699
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/95:45 am -
2 stops13h 53m
Tue 3/169:30 am -
1 stop9h 08m
Deal found 9/14![United Airlines logo]()
$737
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:00 am -
1 stop8h 02m
Sun 10/182:02 pm -
2 stops21h 58m
Deal found 9/16![American Airlines logo]()
$861
This Delta deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:20 am -
1 stop8h 39m
Tue 10/202:24 pm -
1 stop9h 34m
Deal found 9/11![Delta logo]()
$887
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/286:11 pm -
2 stops20h 34m
Sun 3/711:55 pm -
1 stop23h 09m
Deal found 9/14![United Airlines logo]()
$774
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/57:00 am -
1 stop13h 02m
Fri 11/1310:00 am -
1 stop10h 58m
Deal found 9/12![United Airlines logo]()
$819
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:15 am -
1 stop8h 59m
Tue 10/209:45 am -
1 stop9h 54m
Deal found 9/12![United Airlines logo]()
$887
Last-minute flights from Detroit to Panama CityDiscover last-minute flight deals from Detroit to Panama City. Data last updated September 16, 2026 and is based on user searches.
Discover last-minute flight deals from Detroit to Panama City. Data last updated September 16, 2026 and is based on user searches.
This Justfly.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:30 pm -
2 stops18h 00m
Sun 10/43:50 pm -
2 stops23h 50m
Deal found 9/14![Multiple Airlines logo]()
$698
This Expedia deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:30 pm -
2 stops18h 00m
Tue 10/63:50 pm -
2 stops23h 50m
Deal found 9/13![Multiple Airlines logo]()
$712
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/46:00 am -
1 stop7h 16m
Sat 10/172:02 pm -
2 stops21h 38m
Deal found 9/15![American Airlines logo]()
$742
This FlightHub deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:30 pm -
2 stops18h 00m
Tue 10/203:50 pm -
2 stops23h 59m
Deal found 9/11![Multiple Airlines logo]()
$689
This FlightHub deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:12 am -
2 stops29h 18m
Sun 10/183:50 pm -
2 stops23h 59m
Deal found 9/14![Multiple Airlines logo]()
$747
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:30 am -
1 stop15h 01m
Mon 10/199:33 pm -
2 stops13h 23m
Deal found 9/14![Multiple Airlines logo]()
$736
This Expedia deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:39 pm -
2 stops33h 16m
Tue 10/203:50 pm -
2 stops23h 59m
Deal found 9/14![Multiple Airlines logo]()
$729
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:25 am -
1 stop15h 06m
Sun 11/159:31 pm -
2 stops51h 13m
Deal found 9/12![Multiple Airlines logo]()
$669
One-way flights from Detroit to Panama CitySearch for one-way flight options from Detroit to Panama City. Find affordable one-way fares based on user searches. Data last updated September 16, 2026.
Search for one-way flight options from Detroit to Panama City. Find affordable one-way fares based on user searches. Data last updated September 16, 2026.
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/95:35 am -
1 stop9h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![American Airlines logo]()
$252
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:25 pm -
2 stops19h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![American Airlines logo]()
$282
This FlightHub deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:30 pm -
2 stops18h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Multiple Airlines logo]()
$330
This FlightHub deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:10 am -
2 stops21h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Multiple Airlines logo]()
$331
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/266:51 pm -
2 stops26h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Multiple Airlines logo]()
$334
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:41 am -
2 stops50h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![Multiple Airlines logo]()
$345
This Orbitz deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/156:59 pm -
3 stops20h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$348
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:53 pm -
3 stops25h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$361
Find flight deals from Detroit to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTT) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 16, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $573 (American Airlines) |
One-way from | $252 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Detroit to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 16, 2026.
Use the filters below to find and compare flights from Detroit to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
DetroitPanama City
DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl
DTWPTY
Detroit Metropolitan Wayne County
Sun 11/15
7:42 pm-2:13 pm
2 stops18h 31m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$282
DetroitPanama City
DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl
DTWPTY
Detroit Metropolitan Wayne County
Tue 3/9
7:54 pm-3:20 pm
2 stops19h 26m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$296
Quickest round-trip
DetroitPanama City
DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl
DTWPTY
Detroit Metropolitan Wayne County
Tue 10/6
5:30 pm-10:30 am
2 stops18h 00m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$330
DetroitPanama City
DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl
DTWPTY
Detroit Metropolitan Wayne County
Wed 10/28
6:10 am-2:10 am
2 stops21h 00m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$331
DetroitPanama City
DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl
DTWPTY
Detroit Metropolitan Wayne County
Mon 10/26
6:51 pm-8:31 pm
2 stops26h 40m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$334
DetroitPanama City
DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl
DTWPTY
Detroit Metropolitan Wayne County
Sun 11/15
6:59 pm-3:00 pm
3 stops20h 01m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$348
DetroitPanama City
DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl
DTWPTY
Detroit Metropolitan Wayne County
Sat 11/14
6:53 pm-8:29 pm
3 stops25h 36m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$361
DetroitPanama City
DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl
DTWPTY
Detroit Metropolitan Wayne County
Sun 11/8
6:10 am-3:00 pm
3 stops32h 50m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$362
DetroitPanama City
DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl
DTWPTY
Detroit Metropolitan Wayne County
Wed 9/30
5:30 pm-10:30 am
2 stops18h 00m
Panama City Tocumen Intl
Sun 10/4
3:50 pm-4:40 pm
2 stops23h 50m
$699
DetroitPanama City
DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl
DTWPTY
Detroit Metropolitan Wayne County
Tue 3/9
5:45 am-7:38 pm
2 stops13h 53m
Panama City Tocumen Intl
Tue 3/16
9:30 am-7:38 pm
1 stop9h 08m
$737
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from Detroit to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to Panama City in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Detroit-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Detroit-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Detroit-Panama City flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Detroit-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Detroit to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Detroit with our price prediction graph.
DTT-PTY
DTW-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Detroit to Panama City
DTT-PTY
DTW-PTY
What is the cheapest month to book a flight from Detroit to Panama City?
Currently, January is the cheapest month in which you can book a flight from Detroit to Panama City (average of $773). Flying from Detroit to Panama City in April is currently the most expensive (average of $1,093). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Detroit to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Detroit
Panama City flight routes
Popular flights
Alternative routes for Detroit to Panama City
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Detroit to Panama City by cabin class
Find flights from Detroit to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Detroit and Panama City flights
Browse other Detroit and Panama City flight options. Last updated on September 16, 2026.
Other flights from Detroit
Browse through other flights departing from Detroit. Flights are based on user searches made on Cheapflights and were last updated on September 16, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 16, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from Detroit to Panama City
Discover the top 4 airlines that operate flights from Detroit to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 16, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$611 | Average$1,093 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$655 | Average$962 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$708 | Average$811 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$745 | Average$848 | FlexibilityNo cancel fee | On-time71% |