$290+ Cheap flights from Detroit (DTT) to Panama
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/6. Fares are subject to change and may not be available on all flights or dates of travel.
DTT — PTY
May 21 — May 281
Round-trip
1 adult, Economy
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Find cheap flights from Detroit to Panama with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Detroit to Panama
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Cheapest flights from Detroit to PanamaExplore the most affordable flight options available from Detroit to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 21, 2026.
Explore the most affordable flight options available from Detroit to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 21, 2026.
This Mytrip deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:00 am
DTW
- PTY
2 stops28h 15m
Multiple Airlines
Sun 5/314:25 am
PTY
- DTW
3 stops26h 27m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$499
This Mytrip deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:00 am
DTW
- PTY
2 stops28h 15m
Multiple Airlines
Tue 5/265:55 pm
PTY
- DTW
2 stops28h 58m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$576
This FlightHub deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/155:30 pm
DTW
- PTY
2 stops18h 00m
Multiple Airlines
Tue 9/293:50 pm
PTY
- DTW
2 stops23h 42m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$609
This FlightHub deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:30 pm
DTW
- PTY
2 stops18h 00m
Multiple Airlines
Sat 11/77:50 pm
PTY
- DTW
2 stops28h 06m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$615
This Mytrip deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:30 am
DTW
- PTY
3 stops35h 30m
Multiple Airlines
Fri 5/295:55 pm
PTY
- DTW
2 stops28h 58m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$616
This FlightHub deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:30 pm
DTW
- PTY
2 stops18h 00m
Multiple Airlines
Wed 9/303:50 pm
PTY
- DTW
2 stops23h 42m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$617
This Mytrip deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:30 am
DTW
- PTY
3 stops32h 45m
Multiple Airlines
Fri 5/223:10 pm
PTY
- DTW
3 stops30h 30m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$622
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:50 am
DTW
- PTY
1 stop14h 44m
Multiple Airlines
Wed 5/279:33 pm
PTY
- DTW
2 stops26h 05m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$623
Best flights from Detroit to PanamaDiscover carefully curated flight deals from Detroit to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 21, 2026.
Discover carefully curated flight deals from Detroit to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 21, 2026.
This Mytrip deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/97:59 am
DTW
- PTY
3 stops31h 16m
Multiple Airlines
Sat 5/164:25 am
PTY
- DTW
3 stops26h 27m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$673
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1510:55 am
DTW
- PTY
1 stop8h 42m
United Airlines
Tue 9/293:30 pm
PTY
- DTW
1 stop21h 25m
United Airlines
Deal found 4/17![United Airlines logo]()
$713
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:20 am
DTW
- PTY
1 stop8h 36m
Delta
Wed 9/302:21 pm
PTY
- DTW
1 stop8h 19m
Delta
Deal found 4/20![Delta logo]()
$733
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:15 am
DTW
- PTY
1 stop13h 22m
United Airlines
Tue 6/309:45 am
PTY
- DTW
1 stop9h 28m
United Airlines
Deal found 4/17![United Airlines logo]()
$755
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:15 am
DTW
- PTY
1 stop13h 22m
United Airlines
Sun 6/2810:55 pm
PTY
- DTW
1 stop9h 36m
United Airlines
Deal found 4/17![United Airlines logo]()
$780
This United Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:32 am
DTW
- PTY
2 stops12h 05m
United Airlines
Sat 9/269:45 am
PTY
- DTW
1 stop9h 52m
United Airlines
Deal found 4/18![United Airlines logo]()
$790
Last-minute flights from Detroit to PanamaDiscover last-minute flight deals from Detroit to Panama. Data last updated April 21, 2026 and is based on user searches.
Discover last-minute flight deals from Detroit to Panama. Data last updated April 21, 2026 and is based on user searches.
This Mytrip deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:50 am
DTW
- PTY
3 stops35h 10m
Multiple Airlines
Mon 5/410:10 am
PTY
- DTW
3 stops35h 30m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$636
This Mytrip deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:30 am
DTW
- PTY
3 stops35h 30m
Multiple Airlines
Fri 5/295:55 pm
PTY
- DTW
2 stops28h 58m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$616
This Mytrip deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:30 am
DTW
- PTY
3 stops32h 45m
Multiple Airlines
Fri 5/223:10 pm
PTY
- DTW
3 stops30h 30m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$622
This Mytrip deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:00 am
DTW
- PTY
2 stops28h 15m
Multiple Airlines
Tue 5/265:55 pm
PTY
- DTW
2 stops28h 58m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$576
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:50 am
DTW
- PTY
1 stop14h 44m
Multiple Airlines
Wed 5/279:33 pm
PTY
- DTW
2 stops26h 05m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$623
This Mytrip deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:00 am
DTW
- PTY
2 stops28h 15m
Multiple Airlines
Sun 5/314:25 am
PTY
- DTW
3 stops26h 27m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$499
This FlightHub deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/266:10 am
DTW
- PTY
2 stops29h 20m
Multiple Airlines
Wed 6/33:50 pm
PTY
- DTW
2 stops31h 09m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$625
This Mytrip deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/316:00 am
DTW
- PTY
3 stops33h 15m
Multiple Airlines
Mon 6/15:55 pm
PTY
- DTW
2 stops28h 58m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$637
One-way flights from Detroit to PanamaSearch for one-way flight options from Detroit to Panama. Find affordable one-way fares based on user searches. Data last updated April 21, 2026.
Search for one-way flight options from Detroit to Panama. Find affordable one-way fares based on user searches. Data last updated April 21, 2026.
This FlightHub deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:30 pm
DTW
- PTY
2 stops18h 00m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$290
This Justfly.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:00 am
DTW
- PTY
2 stops29h 30m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/236:15 am
DTW
- PTY
3 stops27h 15m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$305
This Priceline deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:10 am
DTW
- PTY
2 stops29h 20m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$313
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:05 pm
DTW
- PTY
3 stops23h 55m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$346
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/812:55 pm
DTW
- PTY
3 stops36h 40m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$348
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/512:44 pm
DTW
- PTY
2 stops21h 31m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$351
This oojo deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:44 pm
DTW
- PTY
3 stops20h 11m
Avianca
Deal found 4/17![Avianca logo]()
$364
Find flight deals from Detroit to Panama
Keep the following information in mind while searching for Detroit to Panama flight deals. Data was last updated April 21, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $499 (Mytrip) |
One-way from | $290 (FlightHub) |
Popular in | April |
Cheapest in | January |
Average price | $1,299 |
Cheapflights Fare Finder
Customize your flight search to find flights from Detroit to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 21, 2026.
Use the filters below to find and compare flights from Detroit to Panama that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
DetroitPanama City
DTW - PTY
DTWPTY
Detroit Metropolitan Wayne County
Sat 5/9
7:59 am-2:15 pm
3 stops31h 16m
Panama City Tocumen Intl
Sat 5/16
4:25 am-7:52 am
3 stops26h 27m
$673
DetroitPanama City
DTW - PTY
DTWPTY
Detroit Metropolitan Wayne County
Tue 9/15
10:55 am-6:37 pm
1 stop8h 42m
Panama City Tocumen Intl
Tue 9/29
3:30 pm-1:55 pm
1 stop21h 25m
$713
Quickest round-trip
DetroitPanama City
DTW - PTY
DTWPTY
Detroit Metropolitan Wayne County
Wed 9/16
5:20 am-12:56 pm
1 stop8h 36m
Panama City Tocumen Intl
Wed 9/30
2:21 pm-11:40 pm
1 stop8h 19m
$733
DetroitPanama City
DTW - PTY
DTWPTY
Detroit Metropolitan Wayne County
Tue 6/16
6:15 am-6:37 pm
1 stop13h 22m
Panama City Tocumen Intl
Tue 6/30
9:45 am-8:13 pm
1 stop9h 28m
$755
DetroitPanama City
DTW - PTY
DTWPTY
Detroit Metropolitan Wayne County
Tue 6/16
6:15 am-6:37 pm
1 stop13h 22m
Panama City Tocumen Intl
Sun 6/28
10:55 pm-9:31 am
1 stop9h 36m
$780
DetroitPanama City
DTW - PTY
DTWPTY
Detroit Metropolitan Wayne County
Sat 9/19
7:32 am-6:37 pm
2 stops12h 05m
Panama City Tocumen Intl
Sat 9/26
9:45 am-8:37 pm
1 stop9h 52m
$790
Cheapest one-way
DetroitPanama City
DTW - PTY
DTWPTY
Detroit Metropolitan Wayne County
Tue 10/6
5:30 pm-10:30 am
2 stops18h 00m
$290
Quickest one-way
DetroitPanama City
DTW - PTY
DTWPTY
Detroit Metropolitan Wayne County
Tue 6/23
3:17 pm-8:06 am
2 stops17h 49m
$304
DetroitPanama City
DTW - PTY
DTWPTY
Detroit Metropolitan Wayne County
Tue 10/6
7:44 pm-2:55 pm
3 stops20h 11m
$364
DetroitPanama City
DTW - PTY
DTWPTY
Detroit Metropolitan Wayne County
Thu 6/4
8:12 pm-12:35 am
3 stops29h 23m
$377
Sorted by cheapest first
Best time to book a flight from Detroit to Panama
Have a flexible travel schedule? Discover the best time to fly to Panama from Detroit with our price prediction graph.
DTW-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Detroit to Panama
DTT-PA0
DTW-PTY
What is the cheapest month to book a flight from Detroit to Panama?
Currently, March is the cheapest month in which you can book a flight from Detroit to Panama (average of $514). Flying from Detroit to Panama in November is currently the most expensive (average of $668). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Detroit to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Detroit to Panama
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Panama by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Detroit to Panama by cabin class
Find flights from Detroit to Panama, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Detroit and Panama flights
Browse other Detroit and Panama flight options. Last updated on April 21, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from Detroit to Panama
Discover the top 4 airlines that operate flights from Detroit to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$611 | Average$801 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$628 | Average$821 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$629 | Average$811 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$668 | Average$907 | FlexibilityNo cancel fee | On-timeN/A |