$252+ Cheap flights from Detroit (DTT) to Panama
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/9. Fares are subject to change and may not be available on all flights or dates of travel.
DTT — PTY
Oct 20 — Oct 271
Round-trip
1 adult, Economy
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Find cheap flights from Detroit to Panama with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Detroit to Panama
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Best
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Cheapest flights from Detroit to PanamaExplore the most affordable flight options available from Detroit to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 20, 2026.
Explore the most affordable flight options available from Detroit to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 20, 2026.
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:45 am -
1 stop10h 53m
Tue 12/110:00 am -
1 stop10h 52m
Deal found 9/17![United Airlines logo]()
$569
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:15 am -
2 stops13h 23m
Thu 12/311:35 am -
2 stops22h 04m
Deal found 9/17![United Airlines logo]()
$573
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/277:00 am -
1 stop13h 02m
Wed 12/28:55 am -
1 stop13h 48m
Deal found 9/17![United Airlines logo]()
$599
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/277:00 am -
1 stop13h 02m
Thu 12/38:55 am -
2 stops14h 49m
Deal found 9/17![United Airlines logo]()
$603
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/275:49 pm -
2 stops20h 45m
Wed 12/23:13 pm -
2 stops21h 40m
Deal found 9/18![American Airlines logo]()
$618
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/277:00 am -
1 stop13h 02m
Fri 12/411:35 am -
1 stop11h 08m
Deal found 9/17![United Airlines logo]()
$629
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/27:00 am -
1 stop13h 02m
Mon 11/98:55 am -
1 stop13h 32m
Deal found 9/18![United Airlines logo]()
$630
This BusinessClass deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:15 am -
2 stops13h 23m
Mon 11/304:41 pm -
2 stops24h 25m
Deal found 9/17![Copa Airlines logo]()
$642
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:00 am -
1 stop13h 31m
Tue 10/209:45 am -
1 stop12h 53m
Deal found 9/16![United Airlines logo]()
$661
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:26 am -
2 stops31h 19m
Sun 11/84:41 pm -
2 stops27h 49m
Deal found 9/17![United Airlines logo]()
$664
Best flights from Detroit to PanamaDiscover carefully curated flight deals from Detroit to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 20, 2026.
Discover carefully curated flight deals from Detroit to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 20, 2026.
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/267:00 am -
1 stop13h 02m
Tue 12/110:00 am -
1 stop10h 52m
Deal found 9/18![United Airlines logo]()
$569
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:15 am -
2 stops13h 47m
Wed 12/211:35 am -
2 stops22h 04m
Deal found 9/18![United Airlines logo]()
$573
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:26 am -
2 stops12h 12m
Thu 12/38:55 am -
1 stop13h 48m
Deal found 9/19![United Airlines logo]()
$573
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:45 am -
1 stop10h 53m
Wed 12/28:55 am -
2 stops13h 19m
Deal found 9/18![United Airlines logo]()
$573
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:26 am -
2 stops12h 12m
Tue 12/110:00 am -
1 stop10h 52m
Deal found 9/17![United Airlines logo]()
$573
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/277:00 am -
1 stop13h 02m
Wed 12/28:55 am -
1 stop13h 48m
Deal found 9/18![United Airlines logo]()
$599
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/277:00 am -
1 stop13h 02m
Tue 12/110:00 am -
1 stop10h 52m
Deal found 9/17![United Airlines logo]()
$599
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:15 am -
1 stop13h 22m
Fri 10/163:30 pm -
2 stops18h 54m
Deal found 9/17![United Airlines logo]()
$695
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/288:45 am -
1 stop10h 53m
Fri 12/410:00 am -
2 stops12h 14m
Deal found 9/17![United Airlines logo]()
$736
Last-minute flights from Detroit to PanamaDiscover last-minute flight deals from Detroit to Panama. Data last updated September 20, 2026 and is based on user searches.
Discover last-minute flight deals from Detroit to Panama. Data last updated September 20, 2026 and is based on user searches.
This FlightHub deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/305:30 pm -
2 stops18h 00m
Sun 10/43:50 pm -
2 stops23h 50m
Deal found 9/15![Multiple Airlines logo]()
$699
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:15 am -
1 stop8h 59m
Tue 10/139:45 am -
1 stop12h 53m
Deal found 9/16![United Airlines logo]()
$691
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:15 am -
1 stop13h 22m
Tue 10/133:30 pm -
2 stops18h 54m
Deal found 9/16![United Airlines logo]()
$695
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:15 am -
1 stop13h 22m
Mon 10/199:45 am -
1 stop12h 53m
Deal found 9/16![United Airlines logo]()
$703
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:15 am -
1 stop13h 22m
Fri 10/163:30 pm -
1 stop25h 41m
Deal found 9/17![United Airlines logo]()
$704
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/67:00 am -
1 stop13h 31m
Tue 10/209:45 am -
1 stop12h 53m
Deal found 9/16![United Airlines logo]()
$661
This FlightHub deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:30 pm -
2 stops18h 00m
Fri 10/163:50 pm -
2 stops23h 59m
Deal found 9/16![Multiple Airlines logo]()
$690
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/144:59 pm -
2 stops21h 03m
Wed 10/212:02 pm -
2 stops17h 44m
Deal found 9/16![American Airlines logo]()
$700
This Flighttix deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:10 am -
2 stops21h 00m
Sat 11/73:55 pm -
2 stops32h 01m
Deal found 9/16![Multiple Airlines logo]()
$678
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:00 am -
1 stop8h 02m
Sat 11/73:13 pm -
2 stops19h 32m
Deal found 9/16![American Airlines logo]()
$680
One-way flights from Detroit to PanamaSearch for one-way flight options from Detroit to Panama. Find affordable one-way fares based on user searches. Data last updated September 20, 2026.
Search for one-way flight options from Detroit to Panama. Find affordable one-way fares based on user searches. Data last updated September 20, 2026.
This deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/910:59 am -
1 stop8h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![United Airlines logo]()
$252
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:25 pm -
2 stops19h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![American Airlines logo]()
$282
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/175:30 pm -
2 stops20h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![American Airlines logo]()
$287
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/97:54 pm -
2 stops19h 26m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![American Airlines logo]()
$296
This FlightHub deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:30 pm -
2 stops18h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Multiple Airlines logo]()
$331
This Orbitz deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/156:59 pm -
3 stops20h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$348
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:53 pm -
3 stops25h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$361
This Orbitz deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/176:34 am -
3 stops32h 26m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Multiple Airlines logo]()
$362
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/152:38 pm -
2 stops17h 11m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$364
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:25 am -
1 stop15h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Multiple Airlines logo]()
$370
Find flight deals from Detroit to Panama
Keep the following information in mind while searching for Detroit to Panama flight deals. Data was last updated September 20, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $569 (United Airlines) |
One-way from | $252 |
Cheapflights Fare Finder
Customize your flight search to find flights from Detroit to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 20, 2026.
Use the filters below to find and compare flights from Detroit to Panama that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
DetroitPanama City
DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl
DTWPTY
Detroit Metropolitan Wayne County
Sat 11/14
6:00 am-2:13 pm
1 stop8h 13m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$282
DetroitPanama City
DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl
DTWPTY
Detroit Metropolitan Wayne County
Sun 11/15
7:42 pm-2:13 pm
2 stops18h 31m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$282
DetroitPanama City
DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl
DTWPTY
Detroit Metropolitan Wayne County
Tue 3/9
7:54 pm-3:20 pm
2 stops19h 26m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$296
DetroitPanama City
DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl
DTWPTY
Detroit Metropolitan Wayne County
Tue 10/6
5:30 pm-10:30 am
2 stops18h 00m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$331
DetroitPanama City
DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl
DTWPTY
Detroit Metropolitan Wayne County
Wed 10/28
6:10 am-2:10 am
2 stops21h 00m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$331
DetroitPanama City
DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl
DTWPTY
Detroit Metropolitan Wayne County
Tue 10/27
6:10 am-2:10 am
2 stops21h 00m
Panama City Tocumen Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$331
DetroitPanama City
DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl
DTWPTY
Detroit Metropolitan Wayne County
Thu 11/26
7:00 am-8:02 pm
1 stop13h 02m
Panama City Tocumen Intl
Tue 12/1
10:00 am-8:52 pm
1 stop10h 52m
$569
DetroitPanama City
DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl
DTWPTY
Detroit Metropolitan Wayne County
Thu 11/26
6:15 am-8:02 pm
2 stops13h 47m
Panama City Tocumen Intl
Wed 12/2
11:35 am-9:39 am
2 stops22h 04m
$573
DetroitPanama City
DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl
DTWPTY
Detroit Metropolitan Wayne County
Wed 11/25
7:26 am-7:38 pm
2 stops12h 12m
Panama City Tocumen Intl
Thu 12/3
8:55 am-10:43 pm
1 stop13h 48m
$573
DetroitPanama City
DTW Detroit Metropolitan Wayne County - PTY Panama City Tocumen Intl
DTWPTY
Detroit Metropolitan Wayne County
Wed 11/25
8:45 am-7:38 pm
1 stop10h 53m
Panama City Tocumen Intl
Wed 12/2
8:55 am-10:14 pm
2 stops13h 19m
$573
Showing 1-10 of 15 resultsSorted by cheapest first
Best time to book a flight from Detroit to Panama
Have a flexible travel schedule? Discover the best time to fly to Panama from Detroit with our price prediction graph.
DTW-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Detroit to Panama
DTT-PA0
DTW-PTY
What is the cheapest month to book a flight from Detroit to Panama?
Currently, January is the cheapest month in which you can book a flight from Detroit to Panama (average of $773). Flying from Detroit to Panama in April is currently the most expensive (average of $1,093). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Detroit to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Alternative routes for Detroit to Panama
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Panama by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Detroit to Panama by cabin class
Find flights from Detroit to Panama, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Detroit and Panama flights
Browse other Detroit and Panama flight options. Last updated on September 20, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from Detroit to Panama
Discover the top 4 airlines that operate flights from Detroit to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$611 | Average$1,093 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$655 | Average$962 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$708 | Average$811 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$745 | Average$848 | FlexibilityNo cancel fee | On-time71% |