$150+ Cheap flights from Knoxville to Panama City, FL (TYS - ECP)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/20. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — ECP
May 27 — Jun 31
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Knoxville to Panama CityExplore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 27, 2026.
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 27, 2026.
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/224:00 pm
TYS
- ECP
1 stop3h 37m
Delta
Wed 9/3011:15 am
ECP
- TYS
1 stop6h 02m
Delta
Deal found 4/23![Delta logo]()
$199
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/217:20 pm
TYS
- ECP
1 stop4h 26m
Delta
Tue 9/2911:15 am
ECP
- TYS
1 stop2h 52m
Delta
Deal found 4/23![Delta logo]()
$218
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:40 am
TYS
- ECP
1 stop3h 50m
Delta
Wed 5/279:19 am
ECP
- TYS
1 stop4h 14m
Delta
Deal found 4/22![Delta logo]()
$222
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/217:20 pm
TYS
- ECP
1 stop4h 26m
Delta
Mon 9/287:05 pm
ECP
- TYS
1 stop3h 42m
Delta
Deal found 4/23![Delta logo]()
$237
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/294:00 pm
TYS
- ECP
1 stop3h 37m
Delta
Tue 10/67:05 pm
ECP
- TYS
1 stop3h 41m
Delta
Deal found 4/23![Delta logo]()
$249
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:05 am
TYS
- ECP
1 stop3h 25m
Southwest
Tue 6/212:05 pm
ECP
- TYS
2 stops7h 45m
Southwest
Deal found 4/26![Southwest logo]()
$254
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/17:00 am
TYS
- ECP
1 stop3h 40m
Southwest
Thu 9/1010:00 am
ECP
- TYS
2 stops8h 55m
Southwest
Deal found 4/23![Southwest logo]()
$255
This Southwest deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/61:35 pm
TYS
- ECP
2 stops9h 20m
Southwest
Wed 6/102:25 pm
ECP
- TYS
1 stop4h 55m
Southwest
Deal found 4/24![Southwest logo]()
$268
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:50 am
TYS
- ECP
1 stop5h 15m
Southwest
Sat 9/267:15 am
ECP
- TYS
2 stops11h 05m
Southwest
Deal found 4/23![Southwest logo]()
$273
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/237:35 am
TYS
- ECP
1 stop4h 19m
Delta
Thu 6/257:41 am
ECP
- TYS
1 stop4h 38m
Delta
Deal found 4/26![Delta logo]()
$274
Best flights from Knoxville to Panama CityDiscover carefully curated flight deals from Knoxville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 27, 2026.
Discover carefully curated flight deals from Knoxville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 27, 2026.
This Delta deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/237:35 am
TYS
- ECP
1 stop4h 19m
Delta
Thu 6/257:41 am
ECP
- TYS
1 stop4h 38m
Delta
Deal found 4/26![Delta logo]()
$274
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/57:59 pm
TYS
- ECP
1 stop4h 41m
American Airlines
Tue 6/94:16 pm
ECP
- TYS
1 stop6h 31m
American Airlines
Deal found 4/22![American Airlines logo]()
$284
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/251:35 pm
TYS
- ECP
2 stops9h 20m
Southwest
Sat 8/16:35 am
ECP
- TYS
1 stop5h 20m
Southwest
Deal found 4/25![Southwest logo]()
$304
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/251:35 pm
TYS
- ECP
2 stops9h 20m
Southwest
Wed 7/292:25 pm
ECP
- TYS
1 stop4h 55m
Southwest
Deal found 4/23![Southwest logo]()
$304
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/37:05 am
TYS
- ECP
2 stops8h 20m
Southwest
Sun 6/77:20 am
ECP
- TYS
2 stops12h 55m
Southwest
Deal found 4/26![Southwest logo]()
$319
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/237:45 am
TYS
- ECP
2 stops9h 00m
Southwest
Sat 5/3011:05 am
ECP
- TYS
1 stop6h 25m
Southwest
Deal found 4/23![Southwest logo]()
$323
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/201:35 pm
TYS
- ECP
2 stops9h 20m
Southwest
Sat 6/277:00 am
ECP
- TYS
2 stops11h 35m
Southwest
Deal found 4/22![Southwest logo]()
$329
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/18:10 am
TYS
- ECP
2 stops12h 30m
Southwest
Mon 7/61:25 pm
ECP
- TYS
2 stops6h 45m
Southwest
Deal found 4/22![Southwest logo]()
$344
This Southwest deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/208:15 am
TYS
- ECP
2 stops11h 40m
Southwest
Wed 5/2712:05 pm
ECP
- TYS
2 stops7h 45m
Southwest
Deal found 4/22![Southwest logo]()
$348
Last-minute flights from Knoxville to Panama CityDiscover last-minute flight deals from Knoxville to Panama City. Data last updated April 27, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Panama City. Data last updated April 27, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:33 pm
TYS
- ECP
1 stop4h 28m
Delta
Mon 5/181:50 pm
ECP
- TYS
1 stop5h 38m
Delta
Deal found 4/23![Delta logo]()
$288
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/197:05 am
TYS
- ECP
1 stop3h 25m
Southwest
Sat 5/2312:40 pm
ECP
- TYS
1 stop4h 50m
Southwest
Deal found 4/26![Southwest logo]()
$284
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:40 am
TYS
- ECP
1 stop3h 50m
Delta
Wed 5/279:19 am
ECP
- TYS
1 stop4h 14m
Delta
Deal found 4/22![Delta logo]()
$222
This Southwest deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/236:40 am
TYS
- ECP
1 stop3h 20m
Southwest
Tue 5/267:15 am
ECP
- TYS
1 stop3h 45m
Southwest
Deal found 4/24![Southwest logo]()
$313
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:05 am
TYS
- ECP
1 stop3h 25m
Southwest
Tue 6/27:15 am
ECP
- TYS
1 stop3h 45m
Southwest
Deal found 4/26![Southwest logo]()
$249
One-way flights from Knoxville to Panama CitySearch for one-way flight options from Knoxville to Panama City. Find affordable one-way fares based on user searches. Data last updated April 27, 2026.
Search for one-way flight options from Knoxville to Panama City. Find affordable one-way fares based on user searches. Data last updated April 27, 2026.
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/207:59 pm
TYS
- ECP
1 stop4h 41m
American Airlines
Deal found 4/24![American Airlines logo]()
$150
This Southwest deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/201:35 pm
TYS
- ECP
2 stops9h 20m
Southwest
Deal found 4/24![Southwest logo]()
$155
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2211:56 am
TYS
- ECP
1 stop5h 08m
Delta
Deal found 4/23![Delta logo]()
$189
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/237:45 am
TYS
- ECP
2 stops9h 00m
Southwest
Deal found 4/25![Southwest logo]()
$194
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/57:46 pm
TYS
- ECP
1 stop4h 58m
Delta
Deal found 4/27![Delta logo]()
$198
This Southwest deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:35 am
TYS
- ECP
2 stops12h 45m
Southwest
Deal found 4/23![Southwest logo]()
$200
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1210:25 am
TYS
- ECP
1 stop3h 25m
Delta
Deal found 4/25![Delta logo]()
$219
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/128:15 am
TYS
- ECP
2 stops11h 40m
Southwest
Deal found 4/25![Southwest logo]()
$224
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/173:50 pm
TYS
- ECP
1 stop6h 55m
Southwest
Deal found 4/26![Southwest logo]()
$269
This American Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/510:22 am
TYS
- ECP
1 stop6h 01m
American Airlines
Deal found 4/26![American Airlines logo]()
$293
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:05 am
TYS
- ECP
2 stops8h 20m
Southwest
Deal found 4/26![Southwest logo]()
$298
Find flight deals from Knoxville to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 27, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $222 (Delta) |
One-way from | $150 (American Airlines) |
Popular in | June |
Cheapest in | August |
Average price | $479 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 27, 2026.
Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Tue 6/23
7:35 am-10:54 am
1 stop4h 19m
Panama City NW Florida Beaches
Thu 6/25
7:41 am-1:19 pm
1 stop4h 38m
$274
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Fri 6/5
7:59 pm-11:40 pm
1 stop4h 41m
Panama City NW Florida Beaches
Tue 6/9
4:16 pm-11:47 pm
1 stop6h 31m
$284
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Sat 7/25
1:35 pm-9:55 pm
2 stops9h 20m
Panama City NW Florida Beaches
Sat 8/1
6:35 am-12:55 pm
1 stop5h 20m
$304
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Sat 7/25
1:35 pm-9:55 pm
2 stops9h 20m
Panama City NW Florida Beaches
Wed 7/29
2:25 pm-8:20 pm
1 stop4h 55m
$304
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Wed 6/3
7:05 am-2:25 pm
2 stops8h 20m
Panama City NW Florida Beaches
Sun 6/7
7:20 am-9:15 pm
2 stops12h 55m
$319
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Sat 5/23
7:45 am-3:45 pm
2 stops9h 00m
Panama City NW Florida Beaches
Sat 5/30
11:05 am-6:30 pm
1 stop6h 25m
$323
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Sat 6/20
1:35 pm-9:55 pm
2 stops9h 20m
Panama City NW Florida Beaches
Sat 6/27
7:00 am-7:35 pm
2 stops11h 35m
$329
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Wed 7/1
8:10 am-7:40 pm
2 stops12h 30m
Panama City NW Florida Beaches
Mon 7/6
1:25 pm-9:10 pm
2 stops6h 45m
$344
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Wed 5/20
8:15 am-6:55 pm
2 stops11h 40m
Panama City NW Florida Beaches
Wed 5/27
12:05 pm-8:50 pm
2 stops7h 45m
$348
Cheapest one-way
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Sat 6/20
1:35 pm-9:55 pm
2 stops9h 20m
$155
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Panama City in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Panama City, Florida flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.
TYS-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Panama City
What is the cheapest month to book a flight from Knoxville to Panama City, Florida?
Currently, August is the cheapest month in which you can book a flight from Knoxville to Panama City, Florida (average of $293). Flying from Knoxville to Panama City, Florida in June is currently the most expensive (average of $498). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to Panama City, Florida?
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated April 27, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Knoxville to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
8.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
8.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
8.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
8.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Panama City?
Book flights to Panama City if you plan to visit one of these locationsMexico Beach
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Find flights from Knoxville to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Knoxville and Panama City flights
Browse other Knoxville and Panama City flight options. Last updated on April 27, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on April 27, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 27, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Knoxville to Panama City
Discover the top 3 airlines that operate flights from Knoxville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 27, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$193 | Average$416 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$257 | Average$333 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$298 | Average$490 | FlexibilityNo cancel fee | On-time71% |