$135+ Cheap flights from Knoxville to Panama City, FL (TYS - ECP)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/8. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — ECP
Sep 5 — Sep 121
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Panama City
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Cheapest flights from Knoxville to Panama CityExplore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 6, 2026.
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 6, 2026.
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:05 pm -
1 stop8h 00m
Mon 9/146:00 am -
1 stop6h 25m
Deal found 8/3![Southwest logo]()
$256
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:40 am -
1 stop3h 36m
Tue 9/151:46 pm -
1 stop5h 29m
Deal found 8/3![Delta logo]()
$258
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:55 pm -
2 stops7h 40m
Tue 9/157:45 am -
1 stop3h 20m
Deal found 8/3![Southwest logo]()
$263
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:40 am -
1 stop3h 34m
Thu 10/156:20 pm -
1 stop4h 39m
Deal found 8/4![Delta logo]()
$269
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/261:55 pm -
2 stops7h 35m
Mon 8/317:05 am -
1 stop4h 15m
Deal found 8/3![Southwest logo]()
$274
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/94:00 pm -
1 stop4h 08m
Sun 9/136:00 am -
1 stop4h 23m
Deal found 8/5![Delta logo]()
$278
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:24 pm -
1 stop4h 54m
Wed 10/149:19 am -
1 stop3h 21m
Deal found 8/4![Delta logo]()
$279
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/272:05 pm -
1 stop7h 55m
Mon 8/317:05 am -
2 stops9h 05m
Deal found 8/4![Southwest logo]()
$284
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/116:23 pm -
1 stop3h 43m
Thu 10/156:20 pm -
1 stop4h 39m
Deal found 8/4![Delta logo]()
$289
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/287:10 am -
2 stops14h 50m
Sat 8/297:45 am -
1 stop3h 10m
Deal found 8/4![Southwest logo]()
$290
Best flights from Knoxville to Panama CityDiscover carefully curated flight deals from Knoxville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 6, 2026.
Discover carefully curated flight deals from Knoxville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 6, 2026.
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:40 am -
1 stop3h 36m
Mon 9/146:20 pm -
1 stop4h 35m
Deal found 8/3![Delta logo]()
$258
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/88:05 am -
2 stops11h 10m
Sat 9/129:30 am -
1 stop8h 55m
Deal found 8/2![Southwest logo]()
$269
This Delta deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/175:40 am -
1 stop3h 36m
Wed 9/236:00 am -
1 stop4h 18m
Deal found 8/1![Delta logo]()
$269
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/261:55 pm -
2 stops7h 35m
Mon 8/317:05 am -
1 stop4h 15m
Deal found 8/3![Southwest logo]()
$274
This Delta deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:40 am -
1 stop3h 34m
Sat 10/245:40 pm -
1 stop3h 42m
Deal found 8/2![Delta logo]()
$269
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/21:55 pm -
2 stops7h 35m
Wed 9/97:45 am -
2 stops11h 10m
Deal found 8/5![Southwest logo]()
$274
This Delta deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:40 am -
1 stop3h 34m
Tue 10/207:07 am -
1 stop5h 33m
Deal found 8/1![Delta logo]()
$279
This Southwest deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/252:05 pm -
1 stop8h 00m
Mon 9/287:05 am -
1 stop4h 15m
Deal found 8/1![Southwest logo]()
$279
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:05 pm -
1 stop8h 00m
Mon 9/145:10 am -
2 stops6h 10m
Deal found 8/3![Southwest logo]()
$336
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:50 am -
2 stops9h 05m
Wed 9/167:45 am -
2 stops11h 10m
Deal found 8/6![Southwest logo]()
$360
Last-minute flights from Knoxville to Panama CityDiscover last-minute flight deals from Knoxville to Panama City. Data last updated August 6, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Panama City. Data last updated August 6, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/261:55 pm -
2 stops7h 35m
Mon 8/317:05 am -
1 stop4h 15m
Deal found 8/3![Southwest logo]()
$274
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/272:05 pm -
1 stop7h 55m
Mon 8/317:05 am -
2 stops9h 05m
Deal found 8/4![Southwest logo]()
$284
This American Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/287:25 pm -
1 stop4h 15m
Sat 8/295:48 pm -
1 stop4h 10m
Deal found 8/4![American Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/287:10 am -
2 stops14h 50m
Sat 8/297:45 am -
1 stop3h 10m
Deal found 8/4![Southwest logo]()
$290
This American Airlines deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:10 am -
1 stop4h 02m
Tue 9/85:48 pm -
1 stop4h 10m
Deal found 8/3![American Airlines logo]()
$269
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:40 am -
1 stop3h 36m
Tue 9/151:46 pm -
1 stop5h 29m
Deal found 8/3![Delta logo]()
$258
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:55 pm -
2 stops7h 40m
Tue 9/157:45 am -
1 stop3h 20m
Deal found 8/3![Southwest logo]()
$263
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/94:00 pm -
1 stop4h 08m
Sun 9/136:00 am -
1 stop4h 23m
Deal found 8/5![Delta logo]()
$278
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:05 pm -
1 stop8h 00m
Mon 9/146:00 am -
1 stop6h 25m
Deal found 8/3![Southwest logo]()
$256
One-way flights from Knoxville to Panama CitySearch for one-way flight options from Knoxville to Panama City. Find affordable one-way fares based on user searches. Data last updated August 6, 2026.
Search for one-way flight options from Knoxville to Panama City. Find affordable one-way fares based on user searches. Data last updated August 6, 2026.
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/85:40 am -
1 stop3h 34m
Deal found 8/3![Delta logo]()
$135
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1612:06 pm -
1 stop4h 26m
Deal found 8/3![Delta logo]()
$145
This American Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/138:13 pm -
1 stop4h 23m
Deal found 8/4![American Airlines logo]()
$155
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:05 am -
2 stops11h 15m
Deal found 8/4![Southwest logo]()
$189
This Delta deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:40 am -
1 stop3h 36m
Deal found 8/1![Delta logo]()
$194
This Delta deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:40 am -
1 stop6h 02m
Deal found 8/3![Delta logo]()
$224
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/207:10 am -
2 stops6h 40m
Deal found 8/4![Southwest logo]()
$229
This Southwest deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:10 am -
2 stops14h 55m
Deal found 8/1![Southwest logo]()
$240
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/131:15 pm -
2 stops8h 00m
Deal found 8/4![Southwest logo]()
$259
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:10 am -
2 stops6h 40m
Deal found 8/3![Southwest logo]()
$269
This Delta deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/166:12 pm -
1 stop2h 56m
Deal found 8/4![Delta logo]()
$319
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/118:05 am -
2 stops11h 05m
Deal found 8/2![Southwest logo]()
$324
Find flight deals from Knoxville to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 6, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $256 (Southwest) |
One-way from | $135 (Delta) |
Popular in | December |
Cheapest in | May |
Average price | $346 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 6, 2026.
Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvillePanama City
TYS Knoxville McGhee Tyson - ECP Panama City NW Florida Beaches
TYSECP
Knoxville McGhee Tyson
Wed 9/9
5:40 am-8:16 am
1 stop3h 36m
Panama City NW Florida Beaches
Mon 9/14
6:20 pm-11:55 pm
1 stop4h 35m
$258
KnoxvillePanama City
TYS Knoxville McGhee Tyson - ECP Panama City NW Florida Beaches
TYSECP
Knoxville McGhee Tyson
Tue 9/8
8:05 am-6:15 pm
2 stops11h 10m
Panama City NW Florida Beaches
Sat 9/12
9:30 am-7:25 pm
1 stop8h 55m
$269
KnoxvillePanama City
TYS Knoxville McGhee Tyson - ECP Panama City NW Florida Beaches
TYSECP
Knoxville McGhee Tyson
Thu 9/17
5:40 am-8:16 am
1 stop3h 36m
Panama City NW Florida Beaches
Wed 9/23
6:00 am-11:18 am
1 stop4h 18m
$269
Quickest round-trip
KnoxvillePanama City
TYS Knoxville McGhee Tyson - ECP Panama City NW Florida Beaches
TYSECP
Knoxville McGhee Tyson
Sat 10/17
5:40 am-8:14 am
1 stop3h 34m
Panama City NW Florida Beaches
Sat 10/24
5:40 pm-10:22 pm
1 stop3h 42m
$269
KnoxvillePanama City
TYS Knoxville McGhee Tyson - ECP Panama City NW Florida Beaches
TYSECP
Knoxville McGhee Tyson
Wed 8/26
1:55 pm-8:30 pm
2 stops7h 35m
Panama City NW Florida Beaches
Mon 8/31
7:05 am-12:20 pm
1 stop4h 15m
$274
KnoxvillePanama City
TYS Knoxville McGhee Tyson - ECP Panama City NW Florida Beaches
TYSECP
Knoxville McGhee Tyson
Wed 9/2
1:55 pm-8:30 pm
2 stops7h 35m
Panama City NW Florida Beaches
Wed 9/9
7:45 am-7:55 pm
2 stops11h 10m
$274
KnoxvillePanama City
TYS Knoxville McGhee Tyson - ECP Panama City NW Florida Beaches
TYSECP
Knoxville McGhee Tyson
Fri 10/16
5:40 am-8:14 am
1 stop3h 34m
Panama City NW Florida Beaches
Tue 10/20
7:07 am-1:40 pm
1 stop5h 33m
$279
KnoxvillePanama City
TYS Knoxville McGhee Tyson - ECP Panama City NW Florida Beaches
TYSECP
Knoxville McGhee Tyson
Fri 9/25
2:05 pm-9:05 pm
1 stop8h 00m
Panama City NW Florida Beaches
Mon 9/28
7:05 am-12:20 pm
1 stop4h 15m
$279
KnoxvillePanama City
TYS Knoxville McGhee Tyson - ECP Panama City NW Florida Beaches
TYSECP
Knoxville McGhee Tyson
Fri 9/11
2:05 pm-9:05 pm
1 stop8h 00m
Panama City NW Florida Beaches
Mon 9/14
5:10 am-12:20 pm
2 stops6h 10m
$336
KnoxvillePanama City
TYS Knoxville McGhee Tyson - ECP Panama City NW Florida Beaches
TYSECP
Knoxville McGhee Tyson
Sat 9/12
6:50 am-2:55 pm
2 stops9h 05m
Panama City NW Florida Beaches
Wed 9/16
7:45 am-7:55 pm
2 stops11h 10m
$360
Showing 1-10 of 22 resultsSorted by cheapest first
Compare providers for flights from Knoxville to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Panama City in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Panama City, Florida flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.
TYS-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Panama City
What is the cheapest month to book a flight from Knoxville to Panama City, Florida?
Currently, May is the cheapest month in which you can book a flight from Knoxville to Panama City, Florida (average of $312). Flying from Knoxville to Panama City, Florida in December is currently the most expensive (average of $720). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Knoxville to Panama City, Florida?
Airfare is below average for this route at the moment.
Knoxville to Panama City, Florida flights typically cost between $278 and $393 in September.The cheapest round-trip price found within the last 5 days was $256 on Southwest (Sep 11-Sep 14).
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated August 6, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Knoxville to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Food
7.0
Overall
8.0
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Crew
8.6
Food
7.0
Overall
8.0
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Crew
8.6
Food
7.0
Overall
8.0
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Crew
8.6
Food
7.0
Overall
8.0
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Related info for your journey
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Knoxville and Panama City flights
Browse other Knoxville and Panama City flight options. Last updated on August 6, 2026.
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Top 3 airlines flying from Knoxville to Panama City
Discover the top 3 airlines that operate flights from Knoxville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 6, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$173 | Average$405 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$247 | Average$335 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$326 | Average$490 | FlexibilityNo cancel fee | On-time71% |