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Panama City

$249+ Cheap flights from Knoxville to Panama City, FL (TYS - ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/25. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — ECP
Dec 5 — Dec 121
Fri 12/5
Fri 12/12
1 adult, Economy
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Cheap flight deals from Knoxville to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 5, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$307
(Delta)

One-way from

$249
(American Airlines)

Popular in

February

Cheapest in

August

Average price

$608
Provider with most accurate pricing for Knoxville McGhee Tyson-Panama City NW Florida Beaches flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Panama City NW Florida Beaches flights.
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From Knoxville McGhee Tyson to Panama City NW Florida Beaches
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One-way flight from Knoxville McGhee Tyson to Panama City NW Florida Beaches
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Highest demand for flights based on searches. 9% potential increase in price ($48 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($16 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Knoxville to Panama City

Cheapest flights from Knoxville to Panama City
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 5, 2025.

This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/273:53 pmTYS - ECP
1 stop5h 39mDelta
Tue 12/26:59 pmECP - TYS
1 stop3h 31mDelta
Deal found 11/2$323
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/276:05 pmTYS - ECP
1 stop6h 02mDelta
Mon 12/17:02 amECP - TYS
1 stop5h 32mDelta
Deal found 11/2$343
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/208:07 pmTYS - ECP
1 stop4h 00mDelta
Sun 11/236:40 pmECP - TYS
1 stop4h 01mDelta
Deal found 11/3$377
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1910:22 amTYS - ECP
1 stop6h 09mDelta
Sun 11/237:02 amECP - TYS
1 stop5h 42mDelta
Deal found 11/4$407
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/228:04 pmTYS - ECP
1 stop4h 45mAmerican Airlines
Tue 12/25:55 pmECP - TYS
1 stop3h 56mAmerican Airlines
Deal found 11/2$423
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/45:44 amTYS - ECP
1 stop4h 00mDelta
Sat 11/156:00 amECP - TYS
1 stop2h 59mDelta
Deal found 11/3$435
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/235:35 amTYS - ECP
1 stop4h 00mDelta
Thu 11/277:23 amECP - TYS
1 stop5h 21mDelta
Deal found 11/2$439
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/235:35 amTYS - ECP
1 stop4h 00mDelta
Mon 12/17:02 amECP - TYS
1 stop5h 32mDelta
Deal found 11/2$443
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/283:53 pmTYS - ECP
1 stop5h 39mDelta
Tue 12/26:59 pmECP - TYS
1 stop3h 31mDelta
Deal found 11/2$446
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/223:53 pmTYS - ECP
1 stop4h 07mDelta
Thu 11/271:32 pmECP - TYS
1 stop4h 22mDelta
Deal found 11/2$462
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/223:53 pmTYS - ECP
1 stop4h 07mDelta
Mon 12/17:02 amECP - TYS
1 stop5h 32mDelta
Deal found 11/2$466

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 5, 2025.
Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.

Fly from

Knoxville

Fly to

Panama City

Route

Depart

Return

Price

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Thu 11/27

3:53 pm-8:32 pm

1 stop5h 39m

Panama City NW Florida Beaches

Tue 12/2

6:59 pm-11:30 pm

1 stop3h 31m

$323

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Thu 11/20

8:07 pm-11:07 pm

1 stop4h 00m

Panama City NW Florida Beaches

Sun 11/23

6:40 pm-11:41 pm

1 stop4h 01m

$377

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Fri 1/30

12:15 pm-5:33 pm

1 stop6h 18m

Panama City NW Florida Beaches

Sat 1/31

12:03 pm-4:49 pm

1 stop3h 46m

$387

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Wed 11/19

10:22 am-3:31 pm

1 stop6h 09m

Panama City NW Florida Beaches

Sun 11/23

7:02 am-1:44 pm

1 stop5h 42m

$407

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sun 1/25

5:30 am-8:37 am

1 stop4h 07m

Panama City NW Florida Beaches

Sun 2/1

6:09 pm-12:13 pm

2 stops17h 04m

$422

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Fri 1/30

5:30 am-8:37 am

1 stop4h 07m

Panama City NW Florida Beaches

Sun 2/1

6:09 pm-8:47 pm

2 stops25h 38m

$422

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 1/24

5:30 am-8:37 am

1 stop4h 07m

Panama City NW Florida Beaches

Sun 2/1

6:09 pm-8:47 pm

2 stops25h 38m

$422

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sun 11/23

5:35 am-8:35 am

1 stop4h 00m

Panama City NW Florida Beaches

Tue 12/2

6:59 pm-11:30 pm

1 stop3h 31m

$423

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Wed 1/28

8:24 am-11:10 am

1 stop3h 46m

Panama City NW Florida Beaches

Sun 2/1

6:09 pm-11:45 pm

1 stop4h 36m

$423

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Tue 1/27

6:05 am-11:33 am

1 stop6h 28m

Panama City NW Florida Beaches

Sun 2/1

6:03 pm-10:54 pm

1 stop3h 51m

$432

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/3

Showing 1-10 of 16 results
1
2

Compare providers for flights from Knoxville to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Panama City in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Panama City, Florida flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Panama City, Florida flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Panama City, Florida flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Panama City, Florida flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama City

What is the cheapest month to book a flight from Knoxville to Panama City, Florida?

Currently, July is the cheapest month in which you can book a flight from Knoxville to Panama City, Florida (average of $57). Flying from Knoxville to Panama City, Florida in February is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to ECP?

Find hourly flight availability from Knoxville to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 5, 2025.

It’s typically best to fly out from Knoxville to Panama City, Florida in the morning. Doing so could potentially save you 10% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated November 5, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,004 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
Delta
7.9
Good
8,004 reviews
Delta
7.9
Good
8,004 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
American Airlines
7.2
Good
11,042 reviews
Delta
7.9
Good
8,004 reviews

Boarding

8.2

Entertainment

7.9

Comfort

7.9

Food

7.3

Overall

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Panama City, Florida?

    For as low as $323, Delta can have you in Panama City, Florida from Knoxville in 5h 39m. The distance between Knoxville and Panama City, Florida is about 390 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Knoxville to Panama City, Florida round-trip?

    Our cheapest airline available from Knoxville to Panama City, Florida is Delta. Our recent data shows that you can find tickets from as low as $258 on this airline. An additional option worth looking into is American Airlines, starting at $328. You may be able to fly from Knoxville to Panama City, Florida for 43% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Knoxville to Panama City, Florida one-way?

    The cheapest airlines for a one-way flight from Knoxville to Panama City, Florida are American Airlines ($249), Delta ($358), and United Airlines ($397).

  • Can I find deals for flights from Knoxville to Panama City that include hotel bookings?

    Yes. In addition to deals on Knoxville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama City.

  • Can I find deals for business class flights from Knoxville to Panama City?

    Yes. Cheapflights offers flight deals from Knoxville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Panama City, Florida?

    Currently, July is the cheapest month in which you can book a flight from Knoxville to Panama City, Florida (average of $57). Flying from Knoxville to Panama City, Florida in February is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
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Top 2 airlines flying from Knoxville to Panama City

Discover the top 2 airlines that operate flights from Knoxville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 5, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$258Average$420FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$328Average$513FlexibilityNo cancel feeOn-time71%

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