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Panama City

$125+ Cheap flights from Knoxville to Panama City, FL (TYS - ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — ECP
Apr 23 — Apr 301
Thu 4/23
Thu 4/30
1 adult, Economy
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Cheap flight deals from Knoxville to Panama City

Cheapest flights from Knoxville to Panama City
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 24, 2026.

This Delta deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:40 am
TYS
-
ECP
1 stop3h 50m
Delta
Mon 5/189:19 am
ECP
-
TYS
1 stop4h 14m
Delta
Deal found 3/23$299
This Southwest deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:40 am
TYS
-
ECP
1 stop8h 35m
Southwest
Mon 6/86:55 am
ECP
-
TYS
1 stop7h 50m
Southwest
Deal found 3/20$303
This Southwest deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/276:55 pm
TYS
-
ECP
1 stop4h 00m
Southwest
Wed 7/17:40 am
ECP
-
TYS
2 stops8h 20m
Southwest
Deal found 3/21$304
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/296:40 am
TYS
-
ECP
2 stops8h 35m
Southwest
Fri 7/31:25 pm
ECP
-
TYS
2 stops6h 45m
Southwest
Deal found 3/23$309
This Southwest deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:45 am
TYS
-
ECP
1 stop11h 05m
Southwest
Sat 6/67:00 am
ECP
-
TYS
2 stops11h 35m
Southwest
Deal found 3/20$310
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:35 am
TYS
-
ECP
2 stops12h 45m
Southwest
Sun 5/39:45 am
ECP
-
TYS
1 stop10h 20m
Southwest
Deal found 3/23$315
This Southwest deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/66:55 pm
TYS
-
ECP
1 stop4h 00m
Southwest
Sat 6/138:30 am
ECP
-
TYS
1 stop11h 50m
Southwest
Deal found 3/20$323

Find flight deals from Knoxville to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 24, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$299
(Southwest)

One-way from

$125
(Southwest)

Popular in

April

Cheapest in

January

Average price

$335
Provider with most accurate pricing for Knoxville McGhee Tyson-Panama City NW Florida Beaches flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Panama City NW Florida Beaches flights.
Search Deals
From Knoxville McGhee Tyson to Panama City NW Florida Beaches
Search Deals
One-way flight from Knoxville McGhee Tyson to Panama City NW Florida Beaches
Search Deals
Highest demand for flights based on searches. 1% potential increase in price ($6 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 24, 2026.
Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Wed 5/13

5:40 am-8:30 am

1 stop3h 50m

Panama City NW Florida Beaches

Mon 5/18

9:19 am-2:33 pm

1 stop4h 14m

$299

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 5/30

7:45 am-5:50 pm

1 stop11h 05m

Panama City NW Florida Beaches

Sat 6/6

7:00 am-7:35 pm

2 stops11h 35m

$310

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Mon 5/11

6:35 am-9:05 am

1 stop3h 30m

Panama City NW Florida Beaches

Sat 5/16

7:55 am-6:30 pm

2 stops9h 35m

$338

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Mon 5/25

6:35 am-4:50 pm

2 stops11h 15m

Panama City NW Florida Beaches

Fri 5/29

9:55 am-8:20 pm

1 stop9h 25m

$354

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Thu 4/30

2:45 pm-9:40 pm

1 stop7h 55m

Panama City NW Florida Beaches

Sun 5/3

9:45 am-9:05 pm

1 stop10h 20m

$383
Quickest round-trip

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Thu 5/21

6:35 am-9:05 am

1 stop3h 30m

Panama City NW Florida Beaches

Sat 5/30

7:20 am-11:40 am

1 stop3h 20m

$416

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 4/4

6:35 am-9:05 am

1 stop3h 30m

Panama City NW Florida Beaches

Mon 4/6

4:55 pm-9:15 pm

1 stop3h 20m

$437

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Mon 4/6

3:45 pm-9:20 pm

1 stop6h 35m

Panama City NW Florida Beaches

Fri 4/10

6:40 am-2:10 pm

1 stop6h 30m

$437
Cheapest one-way
Quickest one-way

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Tue 5/26

7:05 am-9:30 am

1 stop3h 25m

$179

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Tue 4/7

12:11 pm-3:50 pm

1 stop4h 39m

$219

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/19

Showing 1-10 of 18 resultsSorted by cheapest first
1
2

Compare providers for flights from Knoxville to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Panama City in March.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Panama City, Florida flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama City

What is the cheapest month to book a flight from Knoxville to Panama City, Florida?

Currently, July is the cheapest month in which you can book a flight from Knoxville to Panama City, Florida (average of $57). Flying from Knoxville to Panama City, Florida in January is currently the most expensive (average of $281). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated March 24, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andAmerican Airlines from Knoxville to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,331 reviews

Crew

8.6

Entertainment

7.5

Food

7.0

Boarding

8.1

Overall

8.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Southwest
8.0
Very good
4,331 reviews
Southwest
8.0
Very good
4,331 reviews

Crew

8.6

Entertainment

7.5

Food

7.0

Boarding

8.1

Overall

8.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Delta
7.9
Good
8,320 reviews
Southwest
8.0
Very good
4,331 reviews

Crew

8.6

Entertainment

7.5

Food

7.0

Boarding

8.1

Overall

8.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
American Airlines
7.1
Good
11,491 reviews
Southwest
8.0
Very good
4,331 reviews

Crew

8.6

Entertainment

7.5

Food

7.0

Boarding

8.1

Overall

8.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Panama City, Florida?

    For as low as $299, Delta can have you in Panama City, Florida from Knoxville in 3h 50m. The distance between Knoxville and Panama City, Florida is about 390 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Knoxville to Panama City, Florida round-trip?

    Our cheapest airline available from Knoxville to Panama City, Florida is Delta. Our recent data shows that you can find tickets from as low as $235 on this airline. Additional options worth looking into are Southwest and American Airlines, starting at $257 and $298 round-trip. You may be able to fly from Knoxville to Panama City, Florida for 39% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Panama City that include hotel bookings?

    Yes. In addition to deals on Knoxville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama City.

  • Can I find deals for business class flights from Knoxville to Panama City?

    Yes. Cheapflights offers flight deals from Knoxville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Panama City, Florida?

    Currently, July is the cheapest month in which you can book a flight from Knoxville to Panama City, Florida (average of $57). Flying from Knoxville to Panama City, Florida in January is currently the most expensive (average of $281). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

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Top 3 airlines flying from Knoxville to Panama City

Discover the top 3 airlines that operate flights from Knoxville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 24, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$235Average$393FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$257Average$333FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$298Average$490FlexibilityNo cancel feeOn-time71%

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