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Panama City

$249+ Cheap flights from Knoxville to Panama City, FL (TYS - ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — ECP
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from Knoxville to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 16, 2025.

Round-trip from

$323
(Delta)

One-way from

$249
(Delta)

Popular in

November

Cheapest in

August

Average price

$416
From Knoxville McGhee Tyson to Panama City NW Florida Beaches
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One-way flight from Knoxville McGhee Tyson to Panama City NW Florida Beaches
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Highest demand for flights based on searches. 14% potential increase in price ($80 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($24 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Panama City

Cheapest flights from Knoxville to Panama City
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/86:15 amTYS - ECP
1 stop3h 04mDelta
Thu 11/139:20 amECP - TYS
1 stop4h 26mDelta
Deal found 9/15$323
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/176:08 pmTYS - ECP
1 stop5h 55mDelta
Wed 9/246:00 amECP - TYS
1 stop2h 44mDelta
Deal found 9/13$329
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/68:10 pmTYS - ECP
1 stop4h 00mDelta
Mon 10/136:00 amECP - TYS
1 stop3h 45mDelta
Deal found 9/15$347
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/172:08 pmTYS - ECP
1 stop4h 28mAmerican Airlines
Wed 9/246:06 pmECP - TYS
1 stop3h 57mAmerican Airlines
Deal found 9/13$353
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/15:45 amTYS - ECP
1 stop3h 23mDelta
Sun 10/56:00 amECP - TYS
1 stop3h 56mDelta
Deal found 9/16$358
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/195:45 amTYS - ECP
1 stop3h 23mDelta
Sat 9/277:00 amECP - TYS
1 stop5h 10mDelta
Deal found 9/15$396
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/186:30 amTYS - ECP
1 stop4h 12mAmerican Airlines
Sat 9/206:06 pmECP - TYS
1 stop3h 57mAmerican Airlines
Deal found 9/14$426
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/255:45 amTYS - ECP
1 stop3h 23mDelta
Mon 9/296:54 pmECP - TYS
1 stop3h 50mDelta
Deal found 9/13$457
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/202:19 pmTYS - ECP
1 stop4h 17mAmerican Airlines
Mon 9/226:06 pmECP - TYS
1 stop3h 57mAmerican Airlines
Deal found 9/16$475
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2511:17 amTYS - ECP
1 stop3h 42mAmerican Airlines
Sun 9/286:59 pmECP - TYS
1 stop4h 08mAmerican Airlines
Deal found 9/14$485
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:37 pmTYS - ECP
1 stop4h 07mAmerican Airlines
Sun 10/195:30 amECP - TYS
1 stop4h 01mAmerican Airlines
Deal found 9/16$490
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/85:44 amTYS - ECP
1 stop4h 00mDelta
Sun 10/197:10 amECP - TYS
1 stop5h 32mDelta
Deal found 9/14$493

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.

Fly from

Knoxville

Fly to

Panama City

Route

Depart

Return

Price

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Fri 10/17

8:10 pm-11:10 pm

1 stop4h 00m

Panama City NW Florida Beaches

Sat 10/25

5:32 pm-11:07 pm

1 stop4h 35m

$323

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 11/8

6:15 am-8:19 am

1 stop3h 04m

Panama City NW Florida Beaches

Thu 11/13

9:20 am-2:46 pm

1 stop4h 26m

$323

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Tue 9/30

5:45 am-8:08 am

1 stop3h 23m

Panama City NW Florida Beaches

Sat 10/4

6:00 am-10:25 am

1 stop3h 25m

$329

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Mon 10/6

8:10 pm-11:10 pm

1 stop4h 00m

Panama City NW Florida Beaches

Mon 10/13

6:00 am-10:45 am

1 stop3h 45m

$347

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Wed 10/1

5:45 am-8:08 am

1 stop3h 23m

Panama City NW Florida Beaches

Sun 10/5

6:00 am-10:56 am

1 stop3h 56m

$358

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Thu 9/25

5:45 am-8:08 am

1 stop3h 23m

Panama City NW Florida Beaches

Mon 9/29

6:54 pm-11:44 pm

1 stop3h 50m

$457

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Mon 11/10

7:20 pm-11:15 pm

1 stop4h 55m

Panama City NW Florida Beaches

Sun 11/16

7:15 am-2:19 pm

1 stop6h 04m

$490

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Fri 10/17

8:37 pm-11:44 pm

1 stop4h 07m

Panama City NW Florida Beaches

Sun 10/19

5:30 am-10:31 am

1 stop4h 01m

$490

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Thu 9/25

5:45 am-8:08 am

1 stop3h 23m

Panama City NW Florida Beaches

Sun 9/28

7:00 am-10:56 am

1 stop2h 56m

$503

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 10/11

6:11 pm-11:44 pm

1 stop6h 33m

Panama City NW Florida Beaches

Thu 10/16

2:40 pm-7:56 pm

1 stop4h 16m

$508

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 18 results
1
2

Best time to book a flight from Knoxville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama City

What is the cheapest month to book a flight from Knoxville to Panama City, Florida?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Panama City, Florida (average of $346). Flying from Knoxville to Panama City, Florida in March is currently the most expensive (average of $460). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to ECP?

Find hourly flight availability from Knoxville to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

It’s typically best to fly out from Knoxville to Panama City, Florida in the morning. Doing so could potentially save you 11% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated September 16, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,957 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Delta
8.0
Very good
7,957 reviews
Delta
8.0
Very good
7,957 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,957 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Panama City, Florida?

    For as low as $323, Delta can have you in Panama City, Florida from Knoxville in 4h. The distance between Knoxville and Panama City, Florida is about 390 mi.

  • What are the cheapest airlines flying from Knoxville to Panama City, Florida round-trip?

    Our cheapest airline available from Knoxville to Panama City, Florida is Delta. Our recent data shows that you can find tickets from as low as $258 on this airline. An additional option worth looking into is American Airlines, starting at $328. You may be able to fly from Knoxville to Panama City, Florida for 45% less than the average price by searching for these airlines.

  • What are the cheapest airlines to fly from Knoxville to Panama City, Florida one-way?

    The cheapest airlines for a one-way flight from Knoxville to Panama City, Florida are Delta ($249), American Airlines ($249), and United Airlines ($398).

  • Can I find deals for flights from Knoxville to Panama City that include hotel bookings?

    Yes. In addition to deals on Knoxville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama City.

  • Can I find deals for business class flights from Knoxville to Panama City?

    Yes. Cheapflights offers flight deals from Knoxville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Panama City, Florida?

    Currently, January is the cheapest month in which you can book a flight from Knoxville to Panama City, Florida (average of $346). Flying from Knoxville to Panama City, Florida in March is currently the most expensive (average of $460). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

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Top 2 airlines flying from Knoxville to Panama City

Discover the top 2 airlines that operate flights from Knoxville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$258Average$422FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$328Average$503FlexibilityNo cancel feeOn-time71%

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