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Panama City

$187+ Cheap flights from Knoxville to Panama City, FL (TYS - ECP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/6. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — ECP
Nov 21 — Nov 281
Fri 11/21
Fri 11/28
1 adult, Economy
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Cheap flight deals from Knoxville to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 22, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$187
(Delta)

Popular in

November

Cheapest in

August

Average price

$459
Provider with most accurate pricing for Knoxville McGhee Tyson-Panama City NW Florida Beaches flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Panama City NW Florida Beaches flights.
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From Knoxville McGhee Tyson to Panama City NW Florida Beaches
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Highest demand for flights based on searches. 11% potential increase in price ($64 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($24 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Knoxville to Panama City

Cheapest flights from Knoxville to Panama City
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 22, 2025.

This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/63:50 pmTYS - ECP
1 stop4h 10mDelta
Tue 12/91:32 pmECP - TYS
1 stop4h 26mDelta
Deal found 10/21$187
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/65:51 pmTYS - ECP
1 stop7h 13mAmerican Airlines
Tue 12/95:50 pmECP - TYS
1 stop4h 05mAmerican Airlines
Deal found 10/20$247
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/25:40 amTYS - ECP
1 stop4h 34mDelta
Fri 12/121:32 pmECP - TYS
1 stop5h 33mDelta
Deal found 10/20$317
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/185:35 amTYS - ECP
1 stop5h 51mDelta
Tue 11/257:02 amECP - TYS
1 stop5h 42mDelta
Deal found 10/20$327
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/178:07 pmTYS - ECP
1 stop4h 00mDelta
Mon 11/247:02 amECP - TYS
1 stop5h 42mDelta
Deal found 10/20$337
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/85:51 pmTYS - ECP
1 stop7h 02mAmerican Airlines
Wed 11/1212:00 pmECP - TYS
1 stop5h 54mAmerican Airlines
Deal found 10/20$367
This American Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/45:09 pmTYS - ECP
1 stop7h 06mAmerican Airlines
Sat 11/87:15 amECP - TYS
1 stop6h 04mAmerican Airlines
Deal found 10/19$387
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/14:18 pmTYS - ECP
1 stop6h 50mAmerican Airlines
Sat 11/87:15 amECP - TYS
1 stop6h 04mAmerican Airlines
Deal found 10/21$396
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/275:44 amTYS - ECP
1 stop5h 35mDelta
Tue 11/45:00 pmECP - TYS
1 stop5h 22mDelta
Deal found 10/20$427
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/238:10 pmTYS - ECP
1 stop4h 00mDelta
Sat 10/256:00 amECP - TYS
1 stop3h 28mDelta
Deal found 10/20$440

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 22, 2025.
Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.

Fly from

Knoxville

Fly to

Panama City

Route

Depart

Return

Price

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 12/6

3:50 pm-7:00 pm

1 stop4h 10m

Panama City NW Florida Beaches

Tue 12/9

1:32 pm-6:58 pm

1 stop4h 26m

$187

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 12/6

5:51 pm-12:04 am

1 stop7h 13m

Panama City NW Florida Beaches

Tue 12/9

5:50 pm-10:55 pm

1 stop4h 05m

$247

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Tue 11/18

5:35 am-10:26 am

1 stop5h 51m

Panama City NW Florida Beaches

Tue 11/25

7:02 am-1:44 pm

1 stop5h 42m

$327

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Mon 11/17

8:07 pm-11:07 pm

1 stop4h 00m

Panama City NW Florida Beaches

Mon 11/24

7:02 am-1:44 pm

1 stop5h 42m

$337

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 11/1

4:18 pm-10:08 pm

1 stop6h 50m

Panama City NW Florida Beaches

Sat 11/8

7:15 am-2:19 pm

1 stop6h 04m

$396

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Mon 10/27

5:44 am-10:19 am

1 stop5h 35m

Panama City NW Florida Beaches

Tue 11/4

5:00 pm-11:22 pm

1 stop5h 22m

$427

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Thu 10/30

5:44 am-8:44 am

1 stop4h 00m

Panama City NW Florida Beaches

Mon 11/3

5:00 pm-11:46 pm

1 stop5h 46m

$463

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 11/8

5:51 pm-11:53 pm

1 stop7h 02m

Panama City NW Florida Beaches

Thu 11/13

7:15 am-12:59 pm

1 stop4h 44m

$471

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Fri 11/7

5:44 am-8:44 am

1 stop4h 00m

$289

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Tue 11/11

6:00 pm-10:37 pm

1 stop5h 37m

$289

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/22

Showing 1-10 of 12 results
1
2

Compare providers for flights from Knoxville to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Panama City in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Panama City, Florida flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama City

What is the cheapest month to book a flight from Knoxville to Panama City, Florida?

Currently, July is the cheapest month in which you can book a flight from Knoxville to Panama City, Florida (average of $57). Flying from Knoxville to Panama City, Florida in February is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to ECP?

Find hourly flight availability from Knoxville to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 22, 2025.

It’s typically best to fly out from Knoxville to Panama City, Florida in the morning. Doing so could potentially save you 10% on the flight price compared to flying at noon, which is usually more expensive.

How much does it cost to fly round-trip from Knoxville to Panama City, Florida?

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated October 22, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,981 reviews

Overall

7.9

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
Delta
7.9
Good
7,981 reviews
Delta
7.9
Good
7,981 reviews

Overall

7.9

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.
American Airlines
7.2
Good
11,028 reviews
Delta
7.9
Good
7,981 reviews

Overall

7.9

Comfort

7.9

Boarding

8.2

Entertainment

7.9

Food

7.3

Crew

8.5

Reviews

1 / 20
2.0
Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Panama City, Florida?

    For as low as $187, Delta can have you in Panama City, Florida from Knoxville in 4h 10m. The distance between Knoxville and Panama City, Florida is about 390 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Knoxville to Panama City, Florida round-trip?

    Our cheapest airline available from Knoxville to Panama City, Florida is Delta. Our recent data shows that you can find tickets from as low as $258 on this airline. An additional option worth looking into is American Airlines, starting at $328. You may be able to fly from Knoxville to Panama City, Florida for 45% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Panama City that include hotel bookings?

    Yes. In addition to deals on Knoxville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama City.

  • Can I find deals for business class flights from Knoxville to Panama City?

    Yes. Cheapflights offers flight deals from Knoxville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Panama City, Florida?

    Currently, July is the cheapest month in which you can book a flight from Knoxville to Panama City, Florida (average of $57). Flying from Knoxville to Panama City, Florida in February is currently the most expensive (average of $248). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
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Top 2 airlines flying from Knoxville to Panama City

Discover the top 2 airlines that operate flights from Knoxville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$258Average$421FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$328Average$512FlexibilityNo cancel feeOn-time71%

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