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Panama City

$117+ Cheap flights from Knoxville to Panama City, FL (TYS - ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/24. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — ECP
Feb 19 — Feb 261
Thu 2/19
Thu 2/26
1 adult, Economy
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Cheap flight deals from Knoxville to Panama City

Cheapest flights from Knoxville to Panama City
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 20, 2026.

This Southwest deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/253:55 pm
TYS
-
ECP
1 stop5h 30m
Southwest
Sat 5/27:20 am
ECP
-
TYS
1 stop3h 20m
Southwest
Deal found 1/20$235
This Southwest deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/273:45 pm
TYS
-
ECP
1 stop6h 35m
Southwest
Tue 3/317:00 am
ECP
-
TYS
1 stop3h 50m
Southwest
Deal found 1/20$256
This Southwest deal was found by Cheapflights users on 1/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/56:35 am
TYS
-
ECP
2 stops8h 40m
Southwest
Wed 4/159:00 am
ECP
-
TYS
2 stops9h 40m
Southwest
Deal found 1/18$268
This Southwest deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/163:45 pm
TYS
-
ECP
1 stop6h 35m
Southwest
Thu 3/197:20 am
ECP
-
TYS
1 stop4h 25m
Southwest
Deal found 1/19$279
This Southwest deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/292:55 pm
TYS
-
ECP
1 stop6h 50m
Southwest
Sun 5/37:05 am
ECP
-
TYS
1 stop3h 35m
Southwest
Deal found 1/19$289

Find flight deals from Knoxville to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 20, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$235
(Southwest)

One-way from

$117
(American Airlines)

Popular in

February

Cheapest in

August

Average price

$452
Provider with most accurate pricing for Knoxville McGhee Tyson-Panama City NW Florida Beaches flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Panama City NW Florida Beaches flights.
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From Knoxville McGhee Tyson to Panama City NW Florida Beaches
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One-way flight from Knoxville McGhee Tyson to Panama City NW Florida Beaches
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($31 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 20, 2026.
Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.

Fly from

Knoxville

Fly to

Panama City

Route

Depart

Return

Price

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 4/25

3:55 pm-8:25 pm

1 stop5h 30m

Panama City NW Florida Beaches

Sat 5/2

7:20 am-11:40 am

1 stop3h 20m

$235

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Fri 3/27

3:45 pm-9:20 pm

1 stop6h 35m

Panama City NW Florida Beaches

Tue 3/31

7:00 am-11:50 am

1 stop3h 50m

$256

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sun 4/5

2:35 pm-9:50 pm

1 stop8h 15m

Panama City NW Florida Beaches

Wed 4/15

7:55 am-2:20 pm

1 stop5h 25m

$257

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Wed 4/29

2:55 pm-8:45 pm

1 stop6h 50m

Panama City NW Florida Beaches

Sun 5/3

7:05 am-11:40 am

1 stop3h 35m

$289

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Mon 6/1

6:35 am-9:05 am

1 stop3h 30m

Panama City NW Florida Beaches

Thu 6/4

6:55 am-3:45 pm

1 stop7h 50m

$299

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Thu 3/26

5:10 pm-9:22 pm

1 stop5h 12m

Panama City NW Florida Beaches

Sat 3/28

5:30 pm-11:57 pm

1 stop5h 27m

$305

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Fri 3/27

5:40 am-8:39 am

1 stop3h 59m

Panama City NW Florida Beaches

Tue 3/31

11:08 am-4:06 pm

1 stop3h 58m

$316

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Tue 2/24

4:04 pm-10:17 pm

1 stop7h 13m

$117

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Thu 3/12

6:30 am-9:15 am

1 stop3h 45m

$159

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sat 3/7

6:35 am-3:20 pm

2 stops9h 45m

$174

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/20

Showing 1-10 of 14 results
1
2

Compare providers for flights from Knoxville to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Panama City in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Panama City, Florida flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Panama City, Florida flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama City

What is the cheapest month to book a flight from Knoxville to Panama City, Florida?

Currently, July is the cheapest month in which you can book a flight from Knoxville to Panama City, Florida (average of $57). Flying from Knoxville to Panama City, Florida in February is currently the most expensive (average of $285). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated January 20, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,078 reviews

Boarding

8.1

Food

7.2

Comfort

7.9

Entertainment

7.8

Overall

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
Delta
7.9
Good
8,078 reviews
Delta
7.9
Good
8,078 reviews

Boarding

8.1

Food

7.2

Comfort

7.9

Entertainment

7.8

Overall

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
American Airlines
7.2
Good
11,164 reviews
Delta
7.9
Good
8,078 reviews

Boarding

8.1

Food

7.2

Comfort

7.9

Entertainment

7.8

Overall

7.9

Crew

8.5

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Panama City, Florida?

    For as low as $235, Southwest can have you in Panama City, Florida from Knoxville in 5h 30m. The distance between Knoxville and Panama City, Florida is about 390 mi.

  • What are the cheapest airlines flying from Knoxville to Panama City, Florida round-trip?

    Our cheapest airline available from Knoxville to Panama City, Florida is Delta. Our recent data shows that you can find tickets from as low as $228 on this airline. An additional option worth looking into is American Airlines, starting at $326. You may be able to fly from Knoxville to Panama City, Florida for 46% less than the average price by searching for these airlines.

  • Can I find deals for flights from Knoxville to Panama City that include hotel bookings?

    Yes. In addition to deals on Knoxville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama City.

  • Can I find deals for business class flights from Knoxville to Panama City?

    Yes. Cheapflights offers flight deals from Knoxville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Panama City, Florida?

    Currently, July is the cheapest month in which you can book a flight from Knoxville to Panama City, Florida (average of $57). Flying from Knoxville to Panama City, Florida in February is currently the most expensive (average of $285). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
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Top 2 airlines flying from Knoxville to Panama City

Discover the top 2 airlines that operate flights from Knoxville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 20, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$228Average$402FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$326Average$490FlexibilityNo cancel feeOn-time71%

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