What are the cheapest airlines flying from Knoxville to Panama City, Florida round-trip?

Our cheapest airline available from Knoxville to Panama City, Florida is Delta. Our recent data shows that you can find tickets from as low as $293 on this airline. Additional options worth looking into are American Airlines and United Airlines, starting at $313 and $547 round-trip. You may be able to fly from Knoxville to Panama City, Florida for 43% less than the average price by searching for these airlines.

What are the cheapest airlines to fly from Knoxville to Panama City, Florida one-way?

The cheapest airlines for a one-way flight from Knoxville to Panama City, Florida are American Airlines ($339), Delta ($379), and United Airlines ($549).

What is the cheapest day to fly from Knoxville to Panama City, Florida?

Travelers seeking maximum savings on their Knoxville to Panama City, Florida flight should consider departing on Saturday afternoons when fares are most often at their lowest. Thursday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

What is the cheapest day to fly round-trip from Knoxville to Panama City, Florida?

Friday flights are found to be more expensive to fly from Knoxville to Panama City, Florida. This shouldn’t discourage you from searching, as you can still find great deals by being flexible with your options. Use our search form to find deals on tickets to Panama City, Florida.

What is the cheapest month to fly from Knoxville to Panama City, Florida?

Flights from Knoxville to Panama City, Florida lean towards being more expensive in December. Prices are generally better when you fly from Knoxville to Panama City, Florida in August, with the cheapest ticket starting at $358.

Most accurate provider : When it comes to deals on Knoxville-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Panama City, Florida flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Knoxville-Panama City, Florida flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Knoxville to Panama City that include hotel bookings?

Yes. In addition to deals on Knoxville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Knoxville to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama City.

Can I find deals for business class flights from Knoxville to Panama City?

Yes. Cheapflights offers flight deals from Knoxville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$293+ Flights from Knoxville to Panama City, FL - Compare & Save Big

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Knoxville to Panama City with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Panama City

Most accurate provider	FlightHub 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$293 (Delta)
Popular in	December
Cheapest in	August
Average price	$516

Provider with most accurate pricing for Knoxville McGhee Tyson-Panama City NW Florida Beaches flight deals.

Search Deals

Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Panama City NW Florida Beaches flights.

Search Deals

From Knoxville McGhee Tyson to Panama City NW Florida Beaches

Search Deals

Highest demand for flights based on searches. 12% potential increase in price ($73 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 3% potential price decrease ($15 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in April 2025

Search Deals

Find flight deals from Knoxville to Panama City

Cheapest flights from Knoxville to Panama City
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2025.

Sun 6/155:57 pmTYS - ECP

1 stop6h 52mAmerican Airlines

Tue 6/245:26 amECP - TYS

1 stop3h 50mAmerican Airlines

Deal found 4/29

$313

Thu 5/295:45 amTYS - ECP

1 stop3h 31mDelta

Thu 6/56:59 pmECP - TYS

1 stop3h 52mDelta

Deal found 4/29

$353

Tue 5/131:57 pmTYS - ECP

1 stop24h 16mUnited Airlines

Mon 5/192:15 pmECP - TYS

2 stops23h 20mUnited Airlines

Deal found 4/29

$547

Best flights from Knoxville to Panama City
Discover carefully curated flight deals from Knoxville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 30, 2025.

Wed 5/282:04 pmTYS - ECP

1 stop5h 00mDelta

Wed 6/47:15 amECP - TYS

1 stop3h 08mDelta

Deal found 4/29

$293

Sun 6/155:57 pmTYS - ECP

1 stop6h 52mAmerican Airlines

Tue 6/245:26 amECP - TYS

1 stop3h 50mAmerican Airlines

Deal found 4/29

$313

Tue 5/131:57 pmTYS - ECP

1 stop24h 16mUnited Airlines

Mon 5/192:15 pmECP - TYS

2 stops23h 20mUnited Airlines

Deal found 4/29

$547

Last-minute flights from Knoxville to Panama City
Discover last-minute flight deals from Knoxville to Panama City. Data last updated April 30, 2025 and is based on user searches.

Tue 5/65:30 amTYS - ECP

1 stop5h 44mDelta

Tue 5/136:00 amECP - TYS

1 stop4h 23mDelta

Deal found 4/29

$395

Tue 5/65:35 pmTYS - ECP

1 stop20h 38mUnited Airlines

Tue 5/132:15 pmECP - TYS

2 stops23h 20mUnited Airlines

Deal found 4/29

$607

Tue 5/65:05 amTYS - ECP

2 stops7h 50mAmerican Airlines

Tue 5/1310:22 amECP - TYS

1 stop6h 40mAmerican Airlines

Deal found 4/29

$663

Tue 5/131:57 pmTYS - ECP

1 stop24h 16mUnited Airlines

Mon 5/192:15 pmECP - TYS

2 stops23h 20mUnited Airlines

Deal found 4/29

$547

Tue 5/276:51 amTYS - ECP

1 stop6h 04mAmerican Airlines

Tue 6/32:29 pmECP - TYS

1 stop5h 48mAmerican Airlines

Deal found 4/29

$356

Wed 5/282:04 pmTYS - ECP

1 stop5h 00mDelta

Wed 6/47:15 amECP - TYS

1 stop3h 08mDelta

Deal found 4/29

$293

One-way flights from Knoxville to Panama City
Search for one-way flight options from Knoxville to Panama City. Find affordable one-way fares based on user searches. Data last updated April 30, 2025.

Sun 5/119:05 amTYS - ECP

1 stop5h 44mAmerican Airlines

Deal found 4/29

$339

Fri 5/25:30 amTYS - ECP

1 stop3h 56mDelta

Deal found 4/29

$379

Sun 5/119:55 amTYS - ECP

2 stops28h 18mUnited Airlines

Deal found 4/29

$549

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sun 6/15

5:57 pm-11:49 pm

1 stop6h 52m

Panama City NW Florida Beaches

Tue 6/24

5:26 am-10:16 am

1 stop3h 50m

$313

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Thu 5/29

5:45 am-8:16 am

1 stop3h 31m

Panama City NW Florida Beaches

Thu 6/5

6:59 pm-11:51 pm

1 stop3h 52m

$353

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Tue 5/13

1:57 pm-1:13 pm

1 stop24h 16m

Panama City NW Florida Beaches

Mon 5/19

2:15 pm-2:35 pm

2 stops23h 20m

$547

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sun 5/11

9:05 am-1:49 pm

1 stop5h 44m

$339

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Fri 5/2

5:30 am-8:26 am

1 stop3h 56m

$379

KnoxvillePanama City

TYS - ECP

TYSECP

Knoxville McGhee Tyson

Sun 5/11

9:55 am-1:13 pm

2 stops28h 18m

$549

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Compare providers for flights from Knoxville to Panama City

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Panama City in April.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy1 star	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*2 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars
Priceline	Price Accuracy2 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Knoxville-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Panama City, Florida flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Knoxville-Panama City, Florida flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama City

What is the cheapest month to book a flight from Knoxville to Panama City, Florida?

Currently, January is the cheapest month in which you can book a flight from Knoxville to Panama City, Florida (average of $346). Flying from Knoxville to Panama City, Florida in March is currently the most expensive (average of $461). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to ECP?

It’s typically best to fly out from Knoxville to Panama City, Florida in the morning. Doing so could potentially save you 11% on the flight price compared to flying at noon, which is usually more expensive.

Rainfall in Panama City by month

In terms of precipitation, rainfall in Panama City, Florida ranges from 2.8 - 7.9 inches per month. July is typically the wettest month, when rainfall can reach 7.9 in. May is typically the driest time to visit Panama City, Florida when rainfall is around 2.8 in.

Temperature in Panama City by month

If weather is an important factor for your trip to Panama City, Florida, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 53.6 F).

Reviews of airlines servicing Panama City

To help decide which airline to fly from Knoxville to Panama City, see what other customers have to say about Delta, United Airlines and American Airlines. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,936 reviews

Reviews

1 / 20

2.0

Mediocre

Joseph,Aug 2023

MSP - MCO

Even if you have delta comfort plus, they will move your overhead bag. One of the perks for upgrading is that you have dedicated space for your carry on with comfort plus with delta. They moved my carry on luggage (3) compartments back and put in bags for other passengers that should have gone under their respective seats. When deboarding the plane, there was no help from anyone to retrieve my luggage back several rows. Delta is turning into pure garbage.

Delta

8.0

Very good

7,936 reviews

Delta

8.0

Very good

7,936 reviews

Reviews

1 / 20

2.0

Mediocre

Joseph,Aug 2023

MSP - MCO

United Airlines

7.4

Good

8,696 reviews

Delta

8.0

Very good

7,936 reviews

Reviews

1 / 20

2.0

Mediocre

Joseph,Aug 2023

MSP - MCO

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,936 reviews

Reviews

1 / 20

2.0

Mediocre

Joseph,Aug 2023

MSP - MCO

Related info for your journey

What are the cheapest airlines flying from Knoxville to Panama City, Florida round-trip?
Our cheapest airline available from Knoxville to Panama City, Florida is Delta. Our recent data shows that you can find tickets from as low as $293 on this airline. Additional options worth looking into are American Airlines and United Airlines, starting at $313 and $547 round-trip. You may be able to fly from Knoxville to Panama City, Florida for 43% less than the average price by searching for these airlines.
What are the cheapest airlines to fly from Knoxville to Panama City, Florida one-way?
The cheapest airlines for a one-way flight from Knoxville to Panama City, Florida are American Airlines ($339), Delta ($379), and United Airlines ($549).
Can I find deals for flights from Knoxville to Panama City that include hotel bookings?
Yes. In addition to deals on Knoxville to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Knoxville to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Panama City.
Can I find deals for business class flights from Knoxville to Panama City?
Yes. Cheapflights offers flight deals from Knoxville to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Knoxville to Panama City, Florida?
Currently, January is the cheapest month in which you can book a flight from Knoxville to Panama City, Florida (average of $346). Flying from Knoxville to Panama City, Florida in March is currently the most expensive (average of $461). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Mexico Beach

Browse thousands of different options on Cheapflights for your next trip

Top 2 airlines flying from Knoxville to Panama City

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$346	Average$460	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$374	Average$531	FlexibilityNo cancel fee	On-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$293+ Cheap flights from Knoxville to Panama City, FL (TYS - ECP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/28. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Knoxville to Panama City with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Knoxville to Panama City

Most accurate provider

Most trusted provider

Round-trip from

Popular in

Cheapest in

Average price

Find flight deals from Knoxville to Panama City

Cheapest flights from Knoxville to Panama CityExplore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2025.

Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.

Compare providers for flights from Knoxville to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Panama City in April.

Best time to book a flight from Knoxville to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Panama City

What is the cheapest month to book a flight from Knoxville to Panama City, Florida?

What is the cheapest time of day to fly from TYS to ECP?

Find hourly flight availability from Knoxville to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 30, 2025.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

Reviews of airlines servicing Panama City

To help decide which airline to fly from Knoxville to Panama City, see what other customers have to say about Delta, United Airlines and American Airlines. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Knoxville to Panama City, Florida round-trip?

What are the cheapest airlines to fly from Knoxville to Panama City, Florida one-way?

Can I find deals for flights from Knoxville to Panama City that include hotel bookings?

How can I find direct flights from Knoxville to Panama City?

Can I find deals for business class flights from Knoxville to Panama City?

What is the cheapest month to book a flight from Knoxville to Panama City, Florida?

Traveling to a place near Knoxville?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Knoxville to Panama City

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Knoxville to Panama City
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2025.