$140+ Cheap flights from Knoxville to Panama City, FL (TYS - ECP)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/11. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — ECP
Mar 5 — Mar 121
1 adult, Economy
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Find cheap flights from Knoxville to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Panama City
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Best
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Cheapest flights from Knoxville to Panama CityExplore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
Explore the most affordable flight options available from Knoxville to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/72:55 pm
TYS
- ECP
1 stop6h 50m
Southwest
Sat 4/117:55 am
ECP
- TYS
2 stops9h 35m
Southwest
Deal found 2/2![Southwest logo]()
$245
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:35 am
TYS
- ECP
2 stops9h 45m
Southwest
Wed 4/17:30 am
ECP
- TYS
1 stop5h 10m
Southwest
Deal found 2/2![Southwest logo]()
$261
This Southwest deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:35 am
TYS
- ECP
2 stops12h 45m
Southwest
Mon 5/187:10 am
ECP
- TYS
1 stop3h 30m
Southwest
Deal found 1/31![Southwest logo]()
$268
This Southwest deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/72:45 pm
TYS
- ECP
1 stop7h 55m
Southwest
Sun 5/101:50 pm
ECP
- TYS
1 stop7h 10m
Southwest
Deal found 1/31![Southwest logo]()
$279
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:35 am
TYS
- ECP
2 stops9h 45m
Southwest
Sat 4/42:50 pm
ECP
- TYS
1 stop5h 15m
Southwest
Deal found 2/1![Southwest logo]()
$284
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/242:45 pm
TYS
- ECP
1 stop6h 55m
Southwest
Sat 6/276:35 am
ECP
- TYS
1 stop5h 20m
Southwest
Deal found 2/1![Southwest logo]()
$299
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/291:35 pm
TYS
- ECP
2 stops8h 30m
Southwest
Wed 4/17:30 am
ECP
- TYS
1 stop5h 10m
Southwest
Deal found 2/2![Southwest logo]()
$300
Best flights from Knoxville to Panama CityDiscover carefully curated flight deals from Knoxville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
Discover carefully curated flight deals from Knoxville to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 3, 2026.
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/72:55 pm
TYS
- ECP
1 stop6h 50m
Southwest
Sat 4/117:55 am
ECP
- TYS
2 stops9h 35m
Southwest
Deal found 2/2![Southwest logo]()
$245
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:35 am
TYS
- ECP
2 stops9h 45m
Southwest
Wed 4/17:30 am
ECP
- TYS
1 stop5h 10m
Southwest
Deal found 2/2![Southwest logo]()
$261
This Southwest deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:35 am
TYS
- ECP
2 stops12h 45m
Southwest
Mon 5/187:10 am
ECP
- TYS
1 stop3h 30m
Southwest
Deal found 1/31![Southwest logo]()
$268
This Southwest deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/72:45 pm
TYS
- ECP
1 stop7h 55m
Southwest
Sun 5/101:50 pm
ECP
- TYS
1 stop7h 10m
Southwest
Deal found 1/31![Southwest logo]()
$279
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:35 am
TYS
- ECP
2 stops9h 45m
Southwest
Sat 4/42:50 pm
ECP
- TYS
1 stop5h 15m
Southwest
Deal found 2/1![Southwest logo]()
$284
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/237:45 am
TYS
- ECP
1 stop11h 05m
Southwest
Sat 5/307:20 am
ECP
- TYS
1 stop3h 20m
Southwest
Deal found 2/2![Southwest logo]()
$284
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/242:45 pm
TYS
- ECP
1 stop6h 55m
Southwest
Sat 6/276:35 am
ECP
- TYS
1 stop5h 20m
Southwest
Deal found 2/1![Southwest logo]()
$299
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/242:45 pm
TYS
- ECP
1 stop6h 55m
Southwest
Sun 7/267:45 am
ECP
- TYS
1 stop3h 20m
Southwest
Deal found 2/1![Southwest logo]()
$299
Last-minute flights from Knoxville to Panama CityDiscover last-minute flight deals from Knoxville to Panama City. Data last updated February 3, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Panama City. Data last updated February 3, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/26:41 pm
TYS
- ECP
1 stop4h 58m
Delta
Mon 3/96:43 pm
ECP
- TYS
1 stop4h 14m
Delta
Deal found 2/2![Delta logo]()
$362
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:35 am
TYS
- ECP
1 stop4h 06m
Delta
Tue 3/106:00 am
ECP
- TYS
1 stop4h 17m
Delta
Deal found 2/3![Delta logo]()
$327
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/147:50 am
TYS
- ECP
1 stop10h 30m
Southwest
Sat 3/217:25 am
ECP
- TYS
1 stop4h 45m
Southwest
Deal found 2/1![Southwest logo]()
$348
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:35 am
TYS
- ECP
2 stops9h 45m
Southwest
Wed 4/17:30 am
ECP
- TYS
1 stop5h 10m
Southwest
Deal found 2/2![Southwest logo]()
$261
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:35 am
TYS
- ECP
2 stops9h 45m
Southwest
Sat 4/42:50 pm
ECP
- TYS
1 stop5h 15m
Southwest
Deal found 2/1![Southwest logo]()
$284
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/291:35 pm
TYS
- ECP
2 stops8h 30m
Southwest
Wed 4/17:30 am
ECP
- TYS
1 stop5h 10m
Southwest
Deal found 2/2![Southwest logo]()
$300
One-way flights from Knoxville to Panama CitySearch for one-way flight options from Knoxville to Panama City. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
Search for one-way flight options from Knoxville to Panama City. Find affordable one-way fares based on user searches. Data last updated February 3, 2026.
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/112:25 pm
TYS
- ECP
1 stop6h 35m
Southwest
Deal found 2/2![Southwest logo]()
$140
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/125:40 am
TYS
- ECP
1 stop4h 00m
Delta
Deal found 2/2![Delta logo]()
$163
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/126:30 am
TYS
- ECP
2 stops11h 55m
Southwest
Deal found 2/2![Southwest logo]()
$190
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:30 am
TYS
- ECP
1 stop3h 45m
Southwest
Deal found 2/2![Southwest logo]()
$195
This Delta deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/245:35 am
TYS
- ECP
1 stop4h 06m
Delta
Deal found 2/3![Delta logo]()
$209
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/155:10 pm
TYS
- ECP
1 stop3h 17m
Delta
Deal found 2/1![Delta logo]()
$248
This Southwest deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/76:35 am
TYS
- ECP
1 stop7h 30m
Southwest
Deal found 2/1![Southwest logo]()
$254
Find flight deals from Knoxville to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $245 (Southwest) |
One-way from | $140 (Southwest) |
Popular in | February |
Cheapest in | March |
Average price | $508 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Knoxville to Panama City that are best for you.
Fly from
Knoxville
Fly to
Panama City
Route
Depart
Return
Price
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Tue 4/7
2:55 pm-8:45 pm
1 stop6h 50m
Panama City NW Florida Beaches
Sat 4/11
7:55 am-6:30 pm
2 stops9h 35m
$245
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Sat 3/28
6:35 am-3:20 pm
2 stops9h 45m
Panama City NW Florida Beaches
Wed 4/1
7:30 am-1:40 pm
1 stop5h 10m
$261
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Fri 5/8
6:35 am-6:20 pm
2 stops12h 45m
Panama City NW Florida Beaches
Mon 5/18
7:10 am-11:40 am
1 stop3h 30m
$268
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Thu 5/7
2:45 pm-9:40 pm
1 stop7h 55m
Panama City NW Florida Beaches
Sun 5/10
1:50 pm-10:00 pm
1 stop7h 10m
$279
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Sat 3/28
6:35 am-3:20 pm
2 stops9h 45m
Panama City NW Florida Beaches
Sat 4/4
2:50 pm-9:05 pm
1 stop5h 15m
$284
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Sat 5/23
7:45 am-5:50 pm
1 stop11h 05m
Panama City NW Florida Beaches
Sat 5/30
7:20 am-11:40 am
1 stop3h 20m
$284
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Wed 6/24
2:45 pm-8:40 pm
1 stop6h 55m
Panama City NW Florida Beaches
Sat 6/27
6:35 am-12:55 pm
1 stop5h 20m
$299
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Wed 6/24
2:45 pm-8:40 pm
1 stop6h 55m
Panama City NW Florida Beaches
Sun 7/26
7:45 am-12:05 pm
1 stop3h 20m
$299
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Wed 3/11
2:25 pm-8:00 pm
1 stop6h 35m
$140
KnoxvillePanama City
TYS - ECP
TYSECP
Knoxville McGhee Tyson
Thu 3/12
5:40 am-8:40 am
1 stop4h 00m
$163
Showing 1-10 of 16 results
Compare providers for flights from Knoxville to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Panama City in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Knoxville-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Panama City, Florida flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Knoxville-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Knoxville to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Knoxville with our price prediction graph.
TYS-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Panama City
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated February 3, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Panama City by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Boarding
8.1
Crew
8.5
Overall
7.9
Entertainment
7.8
Comfort
7.9
Reviews
1 / 20
8.0
ExcellentLane,Nov 2025
MEM - ATL
Food
7.2
Boarding
8.1
Crew
8.5
Overall
7.9
Entertainment
7.8
Comfort
7.9
Reviews
1 / 20
8.0
ExcellentLane,Nov 2025
MEM - ATL
Food
7.2
Boarding
8.1
Crew
8.5
Overall
7.9
Entertainment
7.8
Comfort
7.9
Reviews
1 / 20
8.0
ExcellentLane,Nov 2025
MEM - ATL
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Panama City?
Book flights to Panama City if you plan to visit one of these locationsMexico Beach
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Knoxville and Panama City flights
Browse other Knoxville and Panama City flight options. Last updated on February 3, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on February 3, 2026.
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Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 3, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Knoxville to Panama City
Discover the top 2 airlines that operate flights from Knoxville to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$228 | Average$390 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$326 | Average$490 | FlexibilityNo cancel fee | On-time71% |