Panama City

$159+ Cheap flights from Iowa to Panama City, FL (ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/12. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — ECP
Jul 14 — Jul 211
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Cheap flight deals from Iowa to Panama City

Cheapest flights from Iowa to Panama City
Explore the most affordable flight options available from Iowa to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 14, 2026.

This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:30 pm
OMA
-
ECP
1 stop4h 17m
Delta
Wed 10/147:05 pm
ECP
-
OMA
1 stop5h 02m
Delta
Deal found 6/11$283
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/133:20 pm
OMA
-
ECP
1 stop6h 15m
Southwest
Wed 8/191:00 pm
ECP
-
OMA
2 stops8h 45m
Southwest
Deal found 6/10$289
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:00 am
MLI
-
ECP
1 stop6h 50m
American Airlines
Wed 9/98:29 am
ECP
-
MLI
1 stop6h 59m
American Airlines
Deal found 6/9$289
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:45 pm
DSM
-
ECP
1 stop4h 30m
Delta
Tue 9/225:30 pm
ECP
-
DSM
1 stop4h 59m
Delta
Deal found 6/9$290
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/141:41 pm
OMA
-
ECP
1 stop6h 27m
Delta
Wed 8/195:26 pm
ECP
-
OMA
1 stop6h 33m
Delta
Deal found 6/12$298
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/85:05 pm
MLI
-
ECP
1 stop6h 32m
Delta
Sat 7/116:00 am
ECP
-
MLI
1 stop4h 12m
Delta
Deal found 6/11$299
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/66:00 am
CID
-
ECP
1 stop4h 42m
Delta
Mon 9/144:28 pm
ECP
-
CID
1 stop5h 34m
Delta
Deal found 6/11$309
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/35:00 pm
MLI
-
ECP
1 stop5h 47m
Delta
Mon 12/76:00 am
ECP
-
MLI
1 stop4h 26m
Delta
Deal found 6/13$309
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/114:15 pm
CID
-
ECP
2 stops6h 31m
Delta
Sat 9/195:30 pm
ECP
-
CID
1 stop4h 32m
Delta
Deal found 6/11$314
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/143:20 pm
OMA
-
ECP
1 stop6h 15m
Southwest
Wed 8/197:45 am
ECP
-
OMA
2 stops8h 20m
Southwest
Deal found 6/12$315
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:45 am
CID
-
ECP
1 stop4h 30m
Delta
Wed 10/284:10 pm
ECP
-
CID
1 stop5h 41m
Delta
Deal found 6/14$316
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:44 am
DSM
-
ECP
1 stop6h 56m
Delta
Thu 10/16:00 am
ECP
-
DSM
1 stop4h 43m
Delta
Deal found 6/11$317

Find flight deals from Iowa to Panama City

Keep the following information in mind while searching for Iowa to Panama City flight deals. Data was last updated June 14, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$273
(Delta)

One-way from

$159
(Delta)

Popular in

November

Cheapest in

August

Average price

$456
Provider with most accurate pricing for Des Moines-Panama City NW Florida Beaches flight deals.
Provider most trusted by Cheapflights users for Des Moines-Panama City NW Florida Beaches flights.
From Iowa to Panama City NW Florida Beaches
One-way flight from Iowa to Panama City NW Florida Beaches
Highest demand for flights based on searches. 9% potential increase in price ($44 potential increase over avg. RT price).
Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
Average for round-trip flights in June 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 14, 2026.
Use the filters below to find and compare flights from Iowa to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MolinePanama City

MLI - ECP

MLIECP

Moline Quad-City

Sat 9/5

7:00 am-1:50 pm

1 stop6h 50m

Panama City NW Florida Beaches

Wed 9/9

8:29 am-3:28 pm

1 stop6h 59m

$289

MolinePanama City

MLI - ECP

MLIECP

Moline Quad-City

Thu 12/3

5:00 pm-10:47 pm

1 stop5h 47m

Panama City NW Florida Beaches

Mon 12/7

6:00 am-10:26 am

1 stop4h 26m

$309

Cedar RapidsPanama City

CID - ECP

CIDECP

Cedar Rapids

Tue 7/7

7:28 am-2:21 pm

1 stop6h 53m

Panama City NW Florida Beaches

Tue 7/14

4:17 pm-10:03 pm

1 stop5h 46m

$309

Cedar RapidsPanama City

CID - ECP

CIDECP

Cedar Rapids

Fri 9/4

12:29 pm-11:30 pm

2 stops11h 01m

Panama City NW Florida Beaches

Fri 9/11

5:00 pm-9:50 pm

1 stop4h 50m

$314

OmahaPanama City

OMA - ECP

OMAECP

Omaha Eppley Airfield

Fri 8/14

1:10 pm-7:00 pm

2 stops5h 50m

Panama City NW Florida Beaches

Wed 8/19

7:45 am-4:05 pm

2 stops8h 20m

$321

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Thu 8/6

2:25 pm-9:35 pm

1 stop7h 10m

Panama City NW Florida Beaches

Mon 8/10

1:30 pm-10:10 pm

2 stops8h 40m

$323

Cedar RapidsPanama City

CID - ECP

CIDECP

Cedar Rapids

Mon 6/29

5:45 am-10:50 am

1 stop5h 05m

Panama City NW Florida Beaches

Fri 7/3

5:08 pm-10:06 pm

1 stop4h 58m

$324

MolinePanama City

MLI - ECP

MLIECP

Moline Quad-City

Sat 8/1

5:10 pm-10:58 pm

1 stop5h 48m

Panama City NW Florida Beaches

Sun 8/9

6:00 am-10:25 am

1 stop4h 25m

$324

MolinePanama City

MLI - ECP

MLIECP

Moline Quad-City

Sun 8/2

5:56 am-12:31 pm

1 stop6h 35m

Panama City NW Florida Beaches

Sun 8/9

6:00 am-10:25 am

1 stop4h 25m

$324

MolinePanama City

MLI - ECP

MLIECP

Moline Quad-City

Sat 6/27

5:17 pm-9:59 pm

1 stop4h 42m

Panama City NW Florida Beaches

Fri 7/3

5:08 pm-10:34 pm

1 stop5h 26m

$334

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Showing 1-10 of 47 resultsSorted by cheapest first
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Best time to book a flight from Iowa to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Panama City

What is the cheapest month to book a flight from Iowa to Panama City, Florida?

Currently, October is the cheapest month in which you can book a flight from Iowa to Panama City, Florida (average of $187). Flying from Iowa to Panama City, Florida in June is currently the most expensive (average of $316). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Iowa to Panama City, Florida?

Related info for your journey

Find useful and relevant information for your journey from Iowa to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly into for flights to Panama City from Iowa?

    Panama City NW Florida Beaches (ECP) is the airport you will fly into if you book a flight from Iowa to Panama City. It is only a 16.0 mi journey from NW Florida Beaches (ECP) to Panama City’s city center.

  • How long is the flight from Iowa to Panama City, Florida?

    For as low as $309, American Airlines can have you in Panama City, Florida from Iowa in 5h 47m. Iowa and Panama City, Florida are separated by a distance of 809 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Iowa to Panama City, Florida?

  • Can I find deals for flights from Iowa to Panama City that include hotel bookings?

    Yes. In addition to deals on Iowa to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Panama City.

  • Can I find deals for business class flights from Iowa to Panama City?

    Yes. Cheapflights offers flight deals from Iowa to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Panama City, Florida?

    Currently, October is the cheapest month in which you can book a flight from Iowa to Panama City, Florida (average of $187). Flying from Iowa to Panama City, Florida in June is currently the most expensive (average of $316). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Mexico Beach

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Alternative routes for Iowa to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Iowa to Panama City

Discover the top 4 airlines that operate flights from Iowa to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 14, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$258Average$455FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$268Average$397FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$297Average$392FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$341Average$474FlexibilityNo cancel feeOn-time69%

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