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Panama City

$160+ Cheap flights from Iowa to Panama City, FL (ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — ECP
Mar 21 — Mar 281
Sat 3/21
Sat 3/28
1 adult, Economy
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Cheap flight deals from Iowa to Panama City

Cheapest flights from Iowa to Panama City
Explore the most affordable flight options available from Iowa to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 19, 2026.

This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/125:32 am
CID
-
ECP
1 stop4h 51m
Delta
Sat 4/185:10 pm
ECP
-
CID
1 stop4h 08m
Delta
Deal found 2/16$269
This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/183:48 pm
MLI
-
ECP
1 stop6h 10m
American Airlines
Fri 4/241:08 pm
ECP
-
MLI
1 stop4h 59m
American Airlines
Deal found 2/18$269
This American Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/56:07 am
CID
-
ECP
1 stop6h 37m
American Airlines
Tue 3/103:00 pm
ECP
-
CID
1 stop6h 25m
American Airlines
Deal found 2/16$274
This American Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/182:02 pm
MLI
-
ECP
2 stops9h 47m
American Airlines
Wed 3/257:19 am
ECP
-
MLI
2 stops11h 13m
American Airlines
Deal found 2/16$279
This Delta deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/255:45 am
CID
-
ECP
1 stop4h 29m
Delta
Mon 6/295:30 pm
ECP
-
CID
1 stop4h 20m
Delta
Deal found 2/19$294
This Delta deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/285:45 am
CID
-
ECP
1 stop6h 53m
Delta
Sat 7/47:45 am
ECP
-
CID
2 stops7h 59m
Delta
Deal found 2/15$299
This Delta deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/245:56 am
MLI
-
ECP
1 stop6h 48m
Delta
Sat 5/306:00 am
ECP
-
MLI
1 stop4h 15m
Delta
Deal found 2/18$299
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/285:01 pm
MLI
-
ECP
1 stop5h 38m
Delta
Thu 3/54:04 pm
ECP
-
MLI
1 stop6h 20m
Delta
Deal found 2/16$309
This United Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:30 am
MLI
-
ECP
1 stop4h 53m
United Airlines
Sat 4/186:30 am
ECP
-
MLI
2 stops10h 36m
United Airlines
Deal found 2/18$310
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/282:50 pm
CID
-
ECP
2 stops7h 49m
Delta
Thu 3/54:04 pm
ECP
-
CID
1 stop5h 20m
Delta
Deal found 2/16$314
This American Airlines deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/243:33 pm
MLI
-
ECP
1 stop5h 49m
American Airlines
Tue 3/38:20 am
ECP
-
MLI
2 stops10h 12m
American Airlines
Deal found 2/16$314
This Delta deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/245:20 pm
DSM
-
ECP
1 stop5h 44m
Delta
Tue 3/315:30 pm
ECP
-
DSM
1 stop5h 08m
Delta
Deal found 2/17$319

Find flight deals from Iowa to Panama City

Keep the following information in mind while searching for Iowa to Panama City flight deals. Data was last updated February 19, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$269
(Delta)

One-way from

$160
(American Airlines)

Popular in

November

Cheapest in

August

Average price

$403
Provider with most accurate pricing for Des Moines-Panama City NW Florida Beaches flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Panama City NW Florida Beaches flights.
Search Deals
From Iowa to Panama City NW Florida Beaches
Search Deals
One-way flight from Iowa to Panama City NW Florida Beaches
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($68 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Iowa to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 19, 2026.
Use the filters below to find and compare flights from Iowa to Panama City that are best for you.

Fly from

Iowa

Fly to

Panama City

Route

Depart

Return

Price

MolinePanama City

MLI - ECP

MLIECP

Moline Quad-City

Sun 4/19

5:11 pm-11:12 pm

1 stop6h 01m

Panama City NW Florida Beaches

Sat 4/25

5:10 pm-10:35 pm

1 stop5h 25m

$269

MolinePanama City

MLI - ECP

MLIECP

Moline Quad-City

Sat 4/18

3:48 pm-9:58 pm

1 stop6h 10m

Panama City NW Florida Beaches

Fri 4/24

1:08 pm-6:07 pm

1 stop4h 59m

$269

MolinePanama City

MLI - ECP

MLIECP

Moline Quad-City

Mon 4/13

1:55 pm-9:59 pm

2 stops8h 04m

Panama City NW Florida Beaches

Sat 4/18

6:30 am-5:06 pm

2 stops10h 36m

$279

MolinePanama City

MLI - ECP

MLIECP

Moline Quad-City

Sun 5/24

5:56 am-12:44 pm

1 stop6h 48m

Panama City NW Florida Beaches

Sat 5/30

6:00 am-10:15 am

1 stop4h 15m

$299

Cedar RapidsPanama City

CID - ECP

CIDECP

Cedar Rapids

Sat 2/28

2:50 pm-10:39 pm

2 stops7h 49m

Panama City NW Florida Beaches

Thu 3/5

4:04 pm-9:24 pm

1 stop5h 20m

$314

Cedar RapidsPanama City

CID - ECP

CIDECP

Cedar Rapids

Sat 2/28

2:50 pm-10:39 pm

2 stops7h 49m

Panama City NW Florida Beaches

Wed 3/4

5:00 pm-9:24 pm

1 stop4h 24m

$314

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 3/24

2:59 pm-9:57 pm

1 stop6h 58m

Panama City NW Florida Beaches

Tue 3/31

4:57 pm-10:43 pm

1 stop5h 46m

$319

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Wed 3/25

5:20 pm-11:04 pm

1 stop5h 44m

Panama City NW Florida Beaches

Tue 3/31

6:00 am-10:48 am

1 stop4h 48m

$319

Cedar RapidsPanama City

CID - ECP

CIDECP

Cedar Rapids

Sun 4/19

5:42 am-10:15 am

1 stop4h 33m

Panama City NW Florida Beaches

Sat 4/25

5:10 pm-9:18 pm

1 stop4h 08m

$319

OmahaPanama City

OMA - ECP

OMAECP

Omaha Eppley Airfield

Tue 3/17

6:09 pm-11:04 pm

1 stop4h 55m

Panama City NW Florida Beaches

Tue 3/24

6:00 am-10:27 am

1 stop4h 27m

$319

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/18

Showing 1-10 of 52 results
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Best time to book a flight from Iowa to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Iowa with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Iowa to Panama City

What is the cheapest month to book a flight from Iowa to Panama City, Florida?

Currently, July is the cheapest month in which you can book a flight from Iowa to Panama City, Florida (average of $108). Flying from Iowa to Panama City, Florida in February is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Iowa to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Iowa?

    Panama City NW Florida Beaches (ECP) is the airport you will fly into if you book a flight from Iowa to Panama City. It is only a 16.0 mi journey from NW Florida Beaches (ECP) to Panama City’s city center.

  • How long is the flight from Iowa to Panama City, Florida?

    For as low as $269, Delta can have you in Panama City, Florida from Iowa in 6h 01m. Iowa and Panama City, Florida are separated by a distance of 809 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Iowa to Panama City, Florida?

    Most travelers choose Des Moines - Panama City NW Florida Beaches, Omaha Eppley Airfield - Panama City NW Florida Beaches or Moline Quad-City - Panama City NW Florida Beaches when deciding on the best route from Iowa to Panama City, Florida.

  • Can I find deals for flights from Iowa to Panama City that include hotel bookings?

    Yes. In addition to deals on Iowa to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Iowa to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Iowa to Panama City.

  • Can I find deals for business class flights from Iowa to Panama City?

    Yes. Cheapflights offers flight deals from Iowa to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Iowa to Panama City, Florida?

    Currently, July is the cheapest month in which you can book a flight from Iowa to Panama City, Florida (average of $108). Flying from Iowa to Panama City, Florida in February is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Mexico Beach

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Alternative routes for Iowa to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Iowa to Panama City

Discover the top 4 airlines that operate flights from Iowa to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 19, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$239Average$405FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$253Average$446FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$254Average$380FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$302Average$397FlexibilityNo cancel feeOn-time63%

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