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Myrtle Beach

$159+ Cheap flights from Knoxville to Myrtle Beach (TYS - MYR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/5. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MYR
Jan 27 — Feb 31
Tue 1/27
Tue 2/3
1 adult, Economy
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Cheap flight deals from Knoxville to Myrtle Beach

Cheapest flights from Knoxville to Myrtle Beach
Explore the most affordable flight options available from Knoxville to Myrtle Beach. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 28, 2025.

This Delta deal was found by Cheapflights users on 12/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:59 pmTYS - MYR
1 stop3h 51mDelta
Sat 1/37:00 amMYR - TYS
1 stop3h 31mDelta
Deal found 12/27$435
This Delta deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:59 pmTYS - MYR
1 stop3h 51mDelta
Thu 1/11:18 pmMYR - TYS
1 stop6h 09mDelta
Deal found 12/26$490
This Kiwi.com deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:07 pmTYS - MYR
1 stop24h 01mMultiple Airlines
Fri 1/26:00 amMYR - TYS
1 stop5h 55mMultiple Airlines
Deal found 12/26$519
This Kiwi.com deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/309:08 amTYS - MYR
1 stop9h 00mMultiple Airlines
Thu 1/12:59 pmMYR - TYS
2 stops17h 34mMultiple Airlines
Deal found 12/26$593
This Delta deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/276:59 pmTYS - MYR
1 stop3h 51mDelta
Tue 12/306:00 amMYR - TYS
1 stop5h 09mDelta
Deal found 12/26$597
This American Airlines deal was found by Cheapflights users on 12/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/304:28 pmTYS - MYR
2 stops7h 27mAmerican Airlines
Sat 1/32:34 pmMYR - TYS
1 stop3h 26mAmerican Airlines
Deal found 12/27$703
This Kiwi.com deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/278:53 amTYS - MYR
1 stop9h 15mMultiple Airlines
Tue 12/3010:45 amMYR - TYS
2 stops34h 22mMultiple Airlines
Deal found 12/26$776
This United Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/317:23 pmTYS - MYR
2 stops17h 43mUnited Airlines
Fri 1/21:47 pmMYR - TYS
2 stops10h 12mUnited Airlines
Deal found 12/26$899
This United Airlines deal was found by Cheapflights users on 12/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/302:00 pmTYS - MYR
2 stops23h 06mUnited Airlines
Thu 1/11:47 pmMYR - TYS
2 stops21h 09mUnited Airlines
Deal found 12/26$1,120
This United Airlines deal was found by Cheapflights users on 12/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:23 pmTYS - MYR
2 stops17h 43mUnited Airlines
Sat 1/312:42 pmMYR - TYS
2 stops21h 33mUnited Airlines
Deal found 12/27$1,435

Find flight deals from Knoxville to Myrtle Beach

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Myrtle Beach (MYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$247
(Kiwi.com)

One-way from

$159
(Delta)

Popular in

January

Cheapest in

August

Average price

$528
Provider with most accurate pricing for Knoxville McGhee Tyson-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Myrtle Beach Intl flights.
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From Knoxville McGhee Tyson to Myrtle Beach Intl
Search Deals
One-way flight from Knoxville McGhee Tyson to Myrtle Beach Intl
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($91 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($19 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Myrtle Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 28, 2025.
Use the filters below to find and compare flights from Knoxville to Myrtle Beach that are best for you.

Fly from

Knoxville

Fly to

Myrtle Beach

Route

Depart

Return

Price

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Sat 1/24

11:59 am-7:20 pm

1 stop7h 21m

Myrtle Beach Intl

Fri 1/30

8:15 pm-11:09 am

1 stop14h 54m

$230

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Mon 3/2

9:36 pm-8:13 am

1 stop10h 37m

Myrtle Beach Intl

Mon 3/9

9:58 am-10:10 am

1 stop24h 12m

$247

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Sat 1/17

6:05 am-9:48 am

1 stop3h 43m

Myrtle Beach Intl

Mon 1/19

6:23 am-9:45 am

1 stop3h 22m

$275

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Thu 3/5

9:13 pm-11:43 am

1 stop14h 30m

Myrtle Beach Intl

Tue 3/10

9:09 am-10:10 am

1 stop25h 01m

$278

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Sat 1/17

11:59 am-7:20 pm

1 stop7h 21m

Myrtle Beach Intl

Mon 1/19

8:15 pm-12:10 pm

2 stops15h 55m

$284

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Tue 3/3

5:35 am-9:45 am

1 stop4h 10m

Myrtle Beach Intl

Sun 3/8

6:00 am-9:16 am

1 stop3h 16m

$286

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Mon 3/2

9:36 pm-8:13 am

1 stop10h 37m

Myrtle Beach Intl

Sun 3/8

4:34 pm-10:24 pm

2 stops29h 50m

$292

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Mon 3/2

5:00 am-8:22 am

1 stop3h 22m

Myrtle Beach Intl

Sat 3/7

6:00 am-11:17 am

1 stop5h 17m

$296

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Mon 3/2

5:35 am-9:45 am

1 stop4h 10m

Myrtle Beach Intl

Sun 3/8

6:00 am-9:16 am

1 stop3h 16m

$296

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Fri 1/9

8:30 am-7:20 pm

1 stop10h 50m

Myrtle Beach Intl

Sun 1/11

9:59 pm-12:05 pm

1 stop14h 06m

$298

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/26

Showing 1-10 of 14 results
1
2

Compare providers for flights from Knoxville to Myrtle Beach

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Myrtle Beach in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Myrtle Beach flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Knoxville-Myrtle Beach flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Knoxville-Myrtle Beach flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Myrtle Beach flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Myrtle Beach flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Myrtle Beach

Have a flexible travel schedule? Discover the best time to fly to Myrtle Beach from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Myrtle Beach

What is the cheapest month to book a flight from Knoxville to Myrtle Beach?

Currently, June is the cheapest month in which you can book a flight from Knoxville to Myrtle Beach (average of $174). Flying from Knoxville to Myrtle Beach in March is currently the most expensive (average of $233). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MYR?

Find hourly flight availability from Knoxville to Myrtle Beach. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 28, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to Myrtle Beach in the afternoon. If you’re flexible enough to do this you can expect to save up to 20% on your trip compared to booking a flight at noon.

Reviews of airlines servicing Myrtle Beach

Get insights into the airlines that provide service to Myrtle Beach. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Myrtle Beach. Reviews last updated December 28, 2025.
Read through reviews of airlines operating flights from Knoxville to Myrtle Beach, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,019 reviews

Entertainment

7.9

Overall

7.9

Food

7.3

Crew

8.5

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,019 reviews
Delta
7.9
Good
8,019 reviews

Entertainment

7.9

Overall

7.9

Food

7.3

Crew

8.5

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,072 reviews
Delta
7.9
Good
8,019 reviews

Entertainment

7.9

Overall

7.9

Food

7.3

Crew

8.5

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Myrtle Beach. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Myrtle Beach?

    American Airlines can get you from Knoxville to Myrtle Beach in just under 3h 43m. Your travel time can differ by up to . Airlines will cover a distance of 323 mi.

  • What are the cheapest airlines flying from Knoxville to Myrtle Beach round-trip?

    American Airlines, at $198, was found to be the cheapest airline from Knoxville to Myrtle Beach. An alternate airline flying to your destination would be Delta. Users have found that American Airlines is 47% cheaper than the other options available to this destination.

  • Can I find deals for flights from Knoxville to Myrtle Beach that include hotel bookings?

    Yes. In addition to deals on Knoxville to Myrtle Beach flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Myrtle Beach?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Myrtle Beach.

  • Can I find deals for business class flights from Knoxville to Myrtle Beach?

    Yes. Cheapflights offers flight deals from Knoxville to Myrtle Beach by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Myrtle Beach?

    Currently, June is the cheapest month in which you can book a flight from Knoxville to Myrtle Beach (average of $174). Flying from Knoxville to Myrtle Beach in March is currently the most expensive (average of $233). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Myrtle Beach?

Book flights to Myrtle Beach if you plan to visit one of these locations
Conway
Surfside Beach
Little River
Pawleys Island
Ocean Isle Beach
Garden City Beach

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Top 2 airlines flying from Knoxville to Myrtle Beach

Discover the top 2 airlines that operate flights from Knoxville to Myrtle Beach. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$309FlexibilityNo cancel feeOn-time71%
DeltaCheapest$228Average$418FlexibilityNo cancel feeOn-timeN/A

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