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Myrtle Beach

$118+ Cheap flights from Knoxville to Myrtle Beach (TYS - MYR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/5. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MYR
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
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Cheap flight deals from Knoxville to Myrtle Beach

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Myrtle Beach (MYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 14, 2025.

Round-trip from

$218
(Kiwi.com)

One-way from

$118
(Kiwi.com)

Popular in

November

Cheapest in

December

Average price

$283
From Knoxville McGhee Tyson to Myrtle Beach Intl
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One-way flight from Knoxville McGhee Tyson to Myrtle Beach Intl
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Highest demand for flights based on searches. 17% potential increase in price ($75 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($20 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Knoxville to Myrtle Beach

Cheapest flights from Knoxville to Myrtle Beach
Explore the most affordable flight options available from Knoxville to Myrtle Beach. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This Kiwi.com deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/97:30 amTYS - MYR
1 stop24h 46mMultiple Airlines
Fri 9/127:17 pmMYR - TYS
1 stop25h 24mMultiple Airlines
Deal found 8/13$218
This Kiwi.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/226:34 pmTYS - MYR
1 stop17h 55mMultiple Airlines
Tue 9/309:04 pmMYR - TYS
1 stop17h 26mMultiple Airlines
Deal found 8/14$228
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/86:30 amTYS - MYR
1 stop4h 03mAmerican Airlines
Sat 11/152:45 pmMYR - TYS
1 stop4h 48mAmerican Airlines
Deal found 8/14$229
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/68:10 pmTYS - MYR
1 stop3h 49mDelta
Mon 10/136:58 pmMYR - TYS
1 stop4h 48mDelta
Deal found 8/14$249
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/185:26 pmTYS - MYR
1 stop5h 45mAmerican Airlines
Thu 8/285:23 amMYR - TYS
1 stop3h 47mAmerican Airlines
Deal found 8/13$264
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/226:05 amTYS - MYR
1 stop3h 23mAmerican Airlines
Sun 8/245:23 amMYR - TYS
1 stop3h 27mAmerican Airlines
Deal found 8/13$269
This Kiwi.com deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/155:27 pmTYS - MYR
2 stops19h 02mMultiple Airlines
Sat 9/209:04 pmMYR - TYS
1 stop17h 25mMultiple Airlines
Deal found 8/13$278
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/168:25 pmTYS - MYR
1 stop3h 20mAmerican Airlines
Sat 8/236:20 pmMYR - TYS
1 stop3h 55mAmerican Airlines
Deal found 8/14$279
This Kiwi.com deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/174:31 pmTYS - MYR
2 stops14h 29mMultiple Airlines
Mon 9/229:04 pmMYR - TYS
1 stop15h 51mMultiple Airlines
Deal found 8/13$281
This Kiwi.com deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1812:08 pmTYS - MYR
1 stop7h 58mMultiple Airlines
Tue 9/234:15 pmMYR - TYS
2 stops23h 26mMultiple Airlines
Deal found 8/13$288

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Myrtle Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Knoxville to Myrtle Beach that are best for you.

Fly from

Knoxville

Fly to

Myrtle Beach

Route

Depart

Return

Price

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Tue 9/9

7:30 am-8:16 am

1 stop24h 46m

Myrtle Beach Intl

Fri 9/12

7:17 pm-8:41 pm

1 stop25h 24m

$218

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Sat 11/8

6:30 am-10:33 am

1 stop4h 03m

Myrtle Beach Intl

Sat 11/15

6:10 pm-11:51 pm

1 stop5h 41m

$229

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Wed 11/12

6:10 pm-11:36 pm

1 stop5h 26m

Myrtle Beach Intl

Wed 11/19

6:00 am-9:11 am

1 stop3h 11m

$229

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Sat 10/4

7:45 pm-11:08 pm

1 stop3h 23m

Myrtle Beach Intl

Tue 10/7

6:00 am-9:52 am

1 stop3h 52m

$229

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Mon 9/15

7:45 pm-11:09 pm

1 stop3h 24m

Myrtle Beach Intl

Sat 9/20

5:29 pm-11:03 pm

1 stop5h 34m

$229

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Fri 9/19

5:05 am-9:33 am

1 stop4h 28m

Myrtle Beach Intl

Sun 9/21

5:15 am-8:37 am

1 stop3h 22m

$229

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Fri 9/19

5:05 am-9:33 am

1 stop4h 28m

Myrtle Beach Intl

Tue 9/23

8:06 am-11:50 am

1 stop3h 44m

$229

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Sat 11/1

12:52 pm-5:14 pm

1 stop4h 22m

Myrtle Beach Intl

Wed 11/5

6:23 am-9:50 am

1 stop3h 27m

$229

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Thu 9/18

4:28 pm-9:50 pm

1 stop5h 22m

Myrtle Beach Intl

Tue 9/23

5:36 pm-11:03 pm

1 stop5h 27m

$229

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Thu 9/11

5:05 am-10:26 am

1 stop5h 21m

Myrtle Beach Intl

Thu 9/18

5:15 am-8:37 am

1 stop3h 22m

$229

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/13

Showing 1-10 of 15 results
1
2

Best time to book a flight from Knoxville to Myrtle Beach

Have a flexible travel schedule? Discover the best time to fly to Myrtle Beach from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Myrtle Beach

What is the cheapest month to book a flight from Knoxville to Myrtle Beach?

Currently, May is the cheapest month in which you can book a flight from Knoxville to Myrtle Beach (average of $196). Flying from Knoxville to Myrtle Beach in March is currently the most expensive (average of $303). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MYR?

Find hourly flight availability from Knoxville to Myrtle Beach. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to Myrtle Beach in the afternoon. If you’re flexible enough to do this you can expect to save up to 21% on your trip compared to booking a flight at noon.

Reviews of airlines servicing Myrtle Beach

Get insights into the airlines that provide service to Myrtle Beach. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Myrtle Beach. Reviews last updated August 14, 2025.
Read through reviews of airlines operating flights from Knoxville to Myrtle Beach, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Overall

8.0

Entertainment

7.9

Boarding

8.2

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Overall

8.0

Entertainment

7.9

Boarding

8.2

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Overall

8.0

Entertainment

7.9

Boarding

8.2

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Myrtle Beach. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Knoxville to Myrtle Beach round-trip?

    Delta, at $218, was found to be the cheapest airline from Knoxville to Myrtle Beach. An alternate airline flying to your destination would be American Airlines. Users have found that Delta is 39% cheaper than the other options available to this destination.

  • Can I find deals for flights from Knoxville to Myrtle Beach that include hotel bookings?

    Yes. In addition to deals on Knoxville to Myrtle Beach flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Myrtle Beach?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Myrtle Beach.

  • Can I find deals for business class flights from Knoxville to Myrtle Beach?

    Yes. Cheapflights offers flight deals from Knoxville to Myrtle Beach by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Myrtle Beach?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to Myrtle Beach (average of $196). Flying from Knoxville to Myrtle Beach in March is currently the most expensive (average of $303). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Myrtle Beach?

Book flights to Myrtle Beach if you plan to visit one of these locations
Conway
Surfside Beach
Little River
Pawleys Island
Ocean Isle Beach
Garden City Beach

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Top 2 airlines flying from Knoxville to Myrtle Beach

Discover the top 2 airlines that operate flights from Knoxville to Myrtle Beach. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$218Average$288FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$350FlexibilityNo cancel feeOn-time71%

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