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Myrtle Beach

$127+ Cheap flights from Knoxville to Myrtle Beach (TYS - MYR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/18. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MYR
Eki 29 — Kas 51
Çar 10/29
Çar 11/5
1 adult, Economy
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Cheap flight deals from Knoxville to Myrtle Beach

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Myrtle Beach (MYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated Eylül 29, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$297
(Kiwi.com)

One-way from

$127
(Kiwi.com)

Popular in

October

Cheapest in

December

Average price

$348
Provider with most accurate pricing for Knoxville McGhee Tyson-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Myrtle Beach Intl flights.
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From Knoxville McGhee Tyson to Myrtle Beach Intl
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One-way flight from Knoxville McGhee Tyson to Myrtle Beach Intl
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Highest demand for flights based on searches. 18% potential increase in price ($83 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($13 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Knoxville to Myrtle Beach

Cheapest flights from Knoxville to Myrtle Beach
Explore the most affordable flight options available from Knoxville to Myrtle Beach. Find the lowest fares from popular airlines and budget airlines, with prices last updated on Eylül 29, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Pzt 10/1312:08 pmTYS - MYR
1 stop7h 56mMultiple Airlines
Per 10/1612:31 pmMYR - TYS
2 stops34h 45mMultiple Airlines
Deal found 9/28$297
This Kiwi.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cum 10/247:44 pmTYS - MYR
1 stop22h 05mMultiple Airlines
Çar 11/511:13 amMYR - TYS
2 stops35h 46mMultiple Airlines
Deal found 9/27$320
This Kiwi.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sal 10/218:00 amTYS - MYR
1 stop11h 11mMultiple Airlines
Paz 10/269:05 pmMYR - TYS
1 stop20h 32mMultiple Airlines
Deal found 9/27$322
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cum 10/247:43 pmTYS - MYR
1 stop3h 11mAmerican Airlines
Çar 11/57:41 pmMYR - TYS
1 stop3h 10mAmerican Airlines
Deal found 9/27$327
This Kiwi.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cum 10/109:06 pmTYS - MYR
1 stop22h 58mMultiple Airlines
Çar 10/159:26 amMYR - TYS
2 stops31h 18mMultiple Airlines
Deal found 9/27$328
This American Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cmt 10/257:00 amTYS - MYR
1 stop3h 26mAmerican Airlines
Cmt 11/19:57 amMYR - TYS
1 stop4h 30mAmerican Airlines
Deal found 9/26$332
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cmt 10/184:18 pmTYS - MYR
1 stop3h 12mAmerican Airlines
Cmt 10/255:21 amMYR - TYS
1 stop5h 10mAmerican Airlines
Deal found 9/27$347
This American Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cmt 10/115:00 amTYS - MYR
1 stop4h 00mAmerican Airlines
Cmt 11/88:07 pmMYR - TYS
1 stop3h 44mAmerican Airlines
Deal found 9/27$352
This Kiwi.com deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Pzt 10/1312:08 pmTYS - MYR
1 stop7h 56mMultiple Airlines
Cum 10/179:25 pmMYR - TYS
2 stops23h 43mMultiple Airlines
Deal found 9/28$365
This American Airlines deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cum 10/178:37 pmTYS - MYR
1 stop3h 22mAmerican Airlines
Sal 10/216:00 amMYR - TYS
1 stop5h 29mAmerican Airlines
Deal found 9/28$367
This Kiwi.com deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cmt 10/1111:08 amTYS - MYR
1 stop8h 56mMultiple Airlines
Per 10/162:59 pmMYR - TYS
2 stops32h 17mMultiple Airlines
Deal found 9/27$370

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Myrtle Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Eylül 29, 2025.
Use the filters below to find and compare flights from Knoxville to Myrtle Beach that are best for you.

Fly from

Knoxville

Fly to

Myrtle Beach

Route

Depart

Return

Price

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Sal 3/10

7:20 pm-11:35 pm

1 stop4h 15m

Myrtle Beach Intl

Çar 3/11

6:00 am-9:13 am

1 stop3h 13m

$317

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Cum 10/24

7:44 pm-5:49 pm

1 stop22h 05m

Myrtle Beach Intl

Çar 11/5

11:13 am-10:59 pm

2 stops35h 46m

$320

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Cmt 10/25

7:00 am-10:26 am

1 stop3h 26m

Myrtle Beach Intl

Cmt 11/1

9:57 am-2:27 pm

1 stop4h 30m

$332

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Cmt 10/18

4:18 pm-7:30 pm

1 stop3h 12m

Myrtle Beach Intl

Cmt 10/25

5:21 am-10:31 am

1 stop5h 10m

$347

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Cum 10/17

8:37 pm-11:59 pm

1 stop3h 22m

Myrtle Beach Intl

Sal 10/21

6:00 am-11:29 am

1 stop5h 29m

$367

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Paz 2/15

5:30 am-10:08 am

1 stop4h 38m

Myrtle Beach Intl

Pzt 2/16

6:45 pm-11:44 pm

1 stop4h 59m

$387

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Cmt 10/11

5:00 am-9:00 am

1 stop4h 00m

Myrtle Beach Intl

Sal 10/14

12:18 pm-4:51 pm

1 stop4h 33m

$391

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Paz 10/12

9:15 pm-8:04 pm

1 stop22h 49m

Myrtle Beach Intl

Paz 10/19

7:43 pm-1:03 pm

1 stop17h 20m

$395

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Pzt 10/13

8:37 pm-11:59 pm

1 stop3h 22m

Myrtle Beach Intl

Per 10/16

5:59 pm-11:53 pm

1 stop5h 54m

$397

KnoxvilleMyrtle Beach

TYS - MYR

TYSMYR

Knoxville McGhee Tyson

Cmt 10/18

11:08 am-8:04 pm

1 stop8h 56m

$127

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/27

Showing 1-10 of 16 results
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Compare providers for flights from Knoxville to Myrtle Beach

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Knoxville to Myrtle Beach in September.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Knoxville-Myrtle Beach flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Knoxville-Myrtle Beach flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Knoxville-Myrtle Beach flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Knoxville-Myrtle Beach flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Knoxville-Myrtle Beach flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Knoxville to Myrtle Beach

Have a flexible travel schedule? Discover the best time to fly to Myrtle Beach from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Myrtle Beach

What is the cheapest month to book a flight from Knoxville to Myrtle Beach?

Currently, May is the cheapest month in which you can book a flight from Knoxville to Myrtle Beach (average of $196). Flying from Knoxville to Myrtle Beach in March is currently the most expensive (average of $303). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to MYR?

Find hourly flight availability from Knoxville to Myrtle Beach. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated Eylül 29, 2025.

A simple way to save on the total cost of your ticket is to fly from Knoxville to Myrtle Beach in the afternoon. If you’re flexible enough to do this you can expect to save up to 21% on your trip compared to booking a flight at noon.

Reviews of airlines servicing Myrtle Beach

Get insights into the airlines that provide service to Myrtle Beach. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Myrtle Beach. Reviews last updated Eylül 29, 2025.
Read through reviews of airlines operating flights from Knoxville to Myrtle Beach, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,964 reviews

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,964 reviews
Delta
8.0
Very good
7,964 reviews

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,964 reviews

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Myrtle Beach. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Knoxville to Myrtle Beach?

    Delta and American Airlines can get you from Knoxville to Myrtle Beach in just under 3h 26m. Your travel time can differ by up to 49m. Airlines will cover a distance of 323 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Knoxville to Myrtle Beach round-trip?

    Delta, at $218, was found to be the cheapest airline from Knoxville to Myrtle Beach. An alternate airline flying to your destination would be American Airlines. Users have found that Delta is 39% cheaper than the other options available to this destination.

  • Can I find deals for flights from Knoxville to Myrtle Beach that include hotel bookings?

    Yes. In addition to deals on Knoxville to Myrtle Beach flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Myrtle Beach?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Myrtle Beach.

  • Can I find deals for business class flights from Knoxville to Myrtle Beach?

    Yes. Cheapflights offers flight deals from Knoxville to Myrtle Beach by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Myrtle Beach?

    Currently, May is the cheapest month in which you can book a flight from Knoxville to Myrtle Beach (average of $196). Flying from Knoxville to Myrtle Beach in March is currently the most expensive (average of $303). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Myrtle Beach?

Book flights to Myrtle Beach if you plan to visit one of these locations
Conway
Surfside Beach
Little River
Pawleys Island
Ocean Isle Beach
Garden City Beach

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Top 2 airlines flying from Knoxville to Myrtle Beach

Discover the top 2 airlines that operate flights from Knoxville to Myrtle Beach. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated Eylül 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$218Average$363FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$319FlexibilityNo cancel feeOn-time71%

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