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Myrtle Beach

$144+ Cheap flights from Des Moines to Myrtle Beach (DSM - MYR)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/11. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MYR
Nov 27 — Dec 41
Thu 11/27
Thu 12/4
1 adult, Economy
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1. Tell us where you want to go

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Cheapflights Tip: The best prices from Des Moines to Myrtle Beach Intl are usually found in August or April, booked 40 days in advance, depart on a Tuesday or Wednesday and return on a Monday

Find flight deals from Des Moines to Myrtle Beach

Cheapest flights from Des Moines to Myrtle Beach
Explore the most affordable flight options available from Des Moines to Myrtle Beach. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/108:00 amDSM - MYR
1 stop23h 20mMultiple Airlines
Fri 11/146:15 amMYR - DSM
2 stops9h 40mMultiple Airlines
Deal found 10/25$254
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/108:00 amDSM - MYR
1 stop23h 20mMultiple Airlines
Wed 11/1211:13 amMYR - DSM
2 stops23h 47mMultiple Airlines
Deal found 10/27$270
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/153:18 pmDSM - MYR
1 stop4h 32mAmerican Airlines
Mon 1/55:13 pmMYR - DSM
1 stop7h 22mAmerican Airlines
Deal found 10/26$313
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/166:17 amDSM - MYR
2 stops10h 44mDelta
Tue 12/3011:09 amMYR - DSM
2 stops9h 53mDelta
Deal found 10/26$323
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/156:33 pmDSM - MYR
1 stop4h 10mDelta
Mon 12/297:00 amMYR - DSM
1 stop4h 38mDelta
Deal found 10/26$350
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/156:15 amDSM - MYR
2 stops10h 10mSouthwest
Mon 1/512:40 pmMYR - DSM
2 stops9h 20mSouthwest
Deal found 10/26$358
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/252:15 pmDSM - MYR
1 stop6h 50mAmerican Airlines
Tue 12/25:41 pmMYR - DSM
1 stop6h 30mAmerican Airlines
Deal found 10/26$362
This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/254:03 pmDSM - MYR
1 stop6h 51mMultiple Airlines
Tue 12/26:15 amMYR - DSM
2 stops58h 16mMultiple Airlines
Deal found 10/26$364

Cheap flight deals from Des Moines to Myrtle Beach

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Myrtle Beach (MYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$254
(Kiwi.com)

One-way from

$144
(Kiwi.com)

Popular in

June

Cheapest in

August

Average price

$406
Provider with most accurate pricing for Des Moines-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Myrtle Beach Intl flights.
Search Deals
From Des Moines to Myrtle Beach Intl
Search Deals
One-way flight from Des Moines to Myrtle Beach Intl
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($30 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Myrtle Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
Use the filters below to find and compare flights from Des Moines to Myrtle Beach that are best for you.

Fly from

Des Moines

Fly to

Myrtle Beach

Route

Depart

Return

Price

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Mon 11/10

8:00 am-8:20 am

1 stop23h 20m

Myrtle Beach Intl

Wed 11/12

11:13 am-10:00 am

2 stops23h 47m

$270

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Mon 2/2

3:34 pm-10:41 am

2 stops18h 07m

Myrtle Beach Intl

Thu 2/5

11:46 am-10:46 pm

1 stop12h 00m

$295

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Tue 12/16

5:34 am-1:55 pm

1 stop7h 21m

Myrtle Beach Intl

Tue 12/30

11:27 am-5:48 pm

1 stop7h 21m

$313

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Mon 2/2

5:16 pm-11:43 pm

1 stop5h 27m

Myrtle Beach Intl

Thu 2/5

6:00 am-10:41 am

1 stop5h 41m

$313

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Mon 2/2

6:10 am-2:25 pm

2 stops7h 15m

Myrtle Beach Intl

Thu 2/5

10:35 am-9:20 pm

2 stops11h 45m

$323

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Mon 11/10

1:37 pm-1:51 pm

3 stops23h 14m

Myrtle Beach Intl

Fri 11/14

6:15 am-2:55 pm

2 stops9h 40m

$328

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Thu 12/11

2:56 pm-5:48 pm

1 stop25h 52m

$144

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Tue 12/2

6:33 pm-11:43 pm

1 stop4h 10m

$159

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Thu 12/11

6:17 am-6:01 pm

2 stops10h 44m

$162

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Tue 12/2

5:00 am-2:46 pm

2 stops8h 46m

$164

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/26

Showing 1-10 of 12 results
1
2

Compare providers for flights from Des Moines to Myrtle Beach

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Myrtle Beach in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Myrtle Beach flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Myrtle Beach flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Myrtle Beach flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Myrtle Beach flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Myrtle Beach flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Myrtle Beach

Have a flexible travel schedule? Discover the best time to fly to Myrtle Beach from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Myrtle Beach

How far ahead should I book a flight from Des Moines to Myrtle Beach?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Myrtle Beach. Price data was last updated on October 24, 2025.

The price you pay for your flight from Des Moines to Myrtle Beach may vary depending on when you book. For the best chance of a lower fare, look to book 40 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to Myrtle Beach?

Currently, May is the cheapest month in which you can book a flight from Des Moines to Myrtle Beach (average of $166). Flying from Des Moines to Myrtle Beach in February is currently the most expensive (average of $310). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to MYR?

Find hourly flight availability from Des Moines to Myrtle Beach. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 28, 2025.

A simple way to save on the total cost of your ticket is to fly from Des Moines to Myrtle Beach in the afternoon. If you’re flexible enough to do this you can expect to save up to 34% on your trip compared to booking a flight in the evening.

Reviews of airlines servicing Myrtle Beach

Get insights into the airlines that provide service to Myrtle Beach. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Myrtle Beach. Reviews last updated October 28, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from Des Moines to Myrtle Beach have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,240 reviews

Boarding

8.1

Entertainment

7.5

Crew

8.6

Comfort

8.0

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,240 reviews
Southwest
8.0
Very good
4,240 reviews

Boarding

8.1

Entertainment

7.5

Crew

8.6

Comfort

8.0

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
7,994 reviews
Southwest
8.0
Very good
4,240 reviews

Boarding

8.1

Entertainment

7.5

Crew

8.6

Comfort

8.0

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
9,001 reviews
Southwest
8.0
Very good
4,240 reviews

Boarding

8.1

Entertainment

7.5

Crew

8.6

Comfort

8.0

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,032 reviews
Southwest
8.0
Very good
4,240 reviews

Boarding

8.1

Entertainment

7.5

Crew

8.6

Comfort

8.0

Overall

8.0

Food

7.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Myrtle Beach. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Myrtle Beach?

    There are many flights that can get you from Des Moines to Myrtle Beach in 7h 21m. Fly via Delta to get the fastest option. Des Moines and Myrtle Beach are separated by a distance of 969 mi.

  • What are the cheapest airlines flying from Des Moines to Myrtle Beach round-trip?

    Our cheapest airline available from Des Moines to Myrtle Beach is American Airlines. Our recent data shows that you can find tickets from as low as $248 on this airline. Additional options worth looking into are Southwest and Delta, starting at $272 and $292 round-trip. American Airlines is currently priced 36% below the average price you’ll pay for this route.

  • Can I find deals for flights from Des Moines to Myrtle Beach that include hotel bookings?

    Yes. In addition to deals on Des Moines to Myrtle Beach flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Myrtle Beach?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Myrtle Beach.

  • Can I find deals for business class flights from Des Moines to Myrtle Beach?

    Yes. Cheapflights offers flight deals from Des Moines to Myrtle Beach by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Myrtle Beach?

    Currently, May is the cheapest month in which you can book a flight from Des Moines to Myrtle Beach (average of $166). Flying from Des Moines to Myrtle Beach in February is currently the most expensive (average of $310). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Myrtle Beach?

Book flights to Myrtle Beach if you plan to visit one of these locations
Conway
Surfside Beach
Little River
Pawleys Island
Ocean Isle Beach
Garden City Beach

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Top 4 airlines flying from Des Moines to Myrtle Beach

Discover the top 4 airlines that operate flights from Des Moines to Myrtle Beach. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$374FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$272Average$404FlexibilityNo cancel feeOn-time63%
DeltaCheapest$292Average$376FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$366Average$436FlexibilityNo cancel feeOn-time69%

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