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Myrtle Beach

$260+ Cheap flights from Des Moines to Myrtle Beach (DSM - MYR)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MYR
Feb 25 — Mar 41
Wed 2/25
Wed 3/4
1 adult, Economy
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Cheap flight deals from Des Moines to Myrtle Beach

Cheapest flights from Des Moines to Myrtle Beach
Explore the most affordable flight options available from Des Moines to Myrtle Beach. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 26, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/107:00 am
DSM
-
MYR
1 stop10h 56m
Multiple Airlines
Wed 5/137:51 pm
MYR
-
DSM
1 stop20h 24m
Multiple Airlines
Deal found 1/25$260
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:21 pm
DSM
-
MYR
2 stops35h 44m
Multiple Airlines
Mon 3/166:37 pm
MYR
-
DSM
1 stop18h 56m
Multiple Airlines
Deal found 1/25$326
This American Airlines deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:00 am
DSM
-
MYR
1 stop4h 39m
American Airlines
Mon 3/95:19 pm
MYR
-
DSM
1 stop7h 23m
American Airlines
Deal found 1/24$329
This Kiwi.com deal was found by Cheapflights users on 1/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/84:30 pm
DSM
-
MYR
2 stops25h 50m
Multiple Airlines
Thu 2/129:09 am
MYR
-
DSM
1 stop15h 03m
Multiple Airlines
Deal found 1/23$333
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/87:00 am
DSM
-
MYR
2 stops48h 13m
Multiple Airlines
Mon 3/166:37 pm
MYR
-
DSM
1 stop18h 56m
Multiple Airlines
Deal found 1/25$340
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:21 pm
DSM
-
MYR
2 stops35h 44m
Multiple Airlines
Sat 3/146:37 pm
MYR
-
DSM
1 stop26h 37m
Multiple Airlines
Deal found 1/25$368
This American Airlines deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/196:00 am
DSM
-
MYR
1 stop4h 39m
American Airlines
Wed 3/256:00 am
MYR
-
DSM
2 stops8h 05m
American Airlines
Deal found 1/24$369
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/87:00 am
DSM
-
MYR
2 stops48h 13m
Multiple Airlines
Sat 3/146:37 pm
MYR
-
DSM
1 stop26h 37m
Multiple Airlines
Deal found 1/25$381
This Southwest deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/105:20 am
DSM
-
MYR
2 stops7h 20m
Southwest
Wed 5/134:05 pm
MYR
-
DSM
2 stops7h 05m
Southwest
Deal found 1/25$384

Find flight deals from Des Moines to Myrtle Beach

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Myrtle Beach (MYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 26, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$260
(Kiwi.com)

Popular in

November

Cheapest in

January

Average price

$297
Provider with most accurate pricing for Des Moines-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Myrtle Beach Intl flights.
Search Deals
From Des Moines to Myrtle Beach Intl
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($40 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Myrtle Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
Use the filters below to find and compare flights from Des Moines to Myrtle Beach that are best for you.

Fly from

Des Moines

Fly to

Myrtle Beach

Route

Depart

Return

Price

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Sun 5/10

7:00 am-6:56 pm

1 stop10h 56m

Myrtle Beach Intl

Wed 5/13

7:51 pm-3:15 pm

1 stop20h 24m

$260

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Wed 2/25

6:00 am-11:39 am

1 stop4h 39m

Myrtle Beach Intl

Sat 2/28

3:17 pm-11:40 pm

2 stops9h 23m

$322

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Sun 5/10

5:20 am-1:40 pm

2 stops7h 20m

Myrtle Beach Intl

Wed 5/13

4:05 pm-10:10 pm

2 stops7h 05m

$384

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Sat 7/25

6:30 pm-11:39 pm

1 stop4h 09m

Myrtle Beach Intl

Thu 7/30

6:00 am-10:14 am

1 stop5h 14m

$387

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Sat 7/25

6:30 pm-11:39 pm

1 stop4h 09m

Myrtle Beach Intl

Wed 7/29

1:05 pm-5:42 pm

1 stop5h 37m

$387

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Mon 5/25

6:30 pm-11:38 pm

1 stop4h 08m

Myrtle Beach Intl

Thu 5/28

2:40 pm-9:17 pm

1 stop7h 37m

$387

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Fri 7/24

6:30 pm-11:39 pm

1 stop4h 09m

Myrtle Beach Intl

Wed 7/29

1:05 pm-5:42 pm

1 stop5h 37m

$387

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Mon 7/20

6:00 am-12:58 pm

1 stop5h 58m

Myrtle Beach Intl

Sat 7/25

6:50 am-12:56 pm

1 stop7h 06m

$417

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Thu 7/23

7:00 am-1:39 pm

1 stop5h 39m

Myrtle Beach Intl

Thu 7/30

6:00 am-10:14 am

1 stop5h 14m

$417

Des MoinesMyrtle Beach

DSM - MYR

DSMMYR

Des Moines

Sat 7/25

6:30 pm-11:39 pm

1 stop4h 09m

Myrtle Beach Intl

Mon 8/3

2:40 pm-9:17 pm

1 stop7h 37m

$417

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/25

Compare providers for flights from Des Moines to Myrtle Beach

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Myrtle Beach in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Myrtle Beach flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Myrtle Beach flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Myrtle Beach flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Myrtle Beach flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Myrtle Beach flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Myrtle Beach

Have a flexible travel schedule? Discover the best time to fly to Myrtle Beach from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Myrtle Beach

How far ahead should I book a flight from Des Moines to Myrtle Beach?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Myrtle Beach. Price data was last updated on January 23, 2026.

The price you pay for your flight from Des Moines to Myrtle Beach may vary depending on when you book. For the best chance of a lower fare, look to book 40 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to Myrtle Beach?

Currently, May is the cheapest month in which you can book a flight from Des Moines to Myrtle Beach (average of $166). Flying from Des Moines to Myrtle Beach in February is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Myrtle Beach

Get insights into the airlines that provide service to Myrtle Beach. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Myrtle Beach. Reviews last updated January 26, 2026.
See what other customers who have flown with Delta, United Airlines, and American Airlines from Des Moines to Myrtle Beach have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,111 reviews

Comfort

7.9

Entertainment

7.8

Overall

7.9

Boarding

8.1

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,111 reviews
Delta
7.9
Good
8,111 reviews

Comfort

7.9

Entertainment

7.8

Overall

7.9

Boarding

8.1

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,199 reviews
Delta
7.9
Good
8,111 reviews

Comfort

7.9

Entertainment

7.8

Overall

7.9

Boarding

8.1

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,189 reviews
Delta
7.9
Good
8,111 reviews

Comfort

7.9

Entertainment

7.8

Overall

7.9

Boarding

8.1

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Myrtle Beach. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Myrtle Beach?

    There are many flights that can get you from Des Moines to Myrtle Beach in 4h 39m. Fly via American Airlines or Southwest to get the fastest option. Des Moines and Myrtle Beach are separated by a distance of 969 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Des Moines to Myrtle Beach round-trip?

    Our cheapest airline available from Des Moines to Myrtle Beach is American Airlines. Our recent data shows that you can find tickets from as low as $248 on this airline. Additional options worth looking into are Delta and United Airlines, starting at $296 and $366 round-trip. American Airlines is currently priced 33% below the average price you’ll pay for this route.

  • Can I find deals for flights from Des Moines to Myrtle Beach that include hotel bookings?

    Yes. In addition to deals on Des Moines to Myrtle Beach flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Myrtle Beach?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Myrtle Beach.

  • Can I find deals for business class flights from Des Moines to Myrtle Beach?

    Yes. Cheapflights offers flight deals from Des Moines to Myrtle Beach by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Myrtle Beach?

    Currently, May is the cheapest month in which you can book a flight from Des Moines to Myrtle Beach (average of $166). Flying from Des Moines to Myrtle Beach in February is currently the most expensive (average of $289). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Myrtle Beach?

Book flights to Myrtle Beach if you plan to visit one of these locations
Conway
Surfside Beach
Little River
Pawleys Island
Ocean Isle Beach
Garden City Beach

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See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Des Moines to Myrtle Beach

Discover the top 4 airlines that operate flights from Des Moines to Myrtle Beach. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$360FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$272Average$387FlexibilityNo cancel feeOn-time63%
DeltaCheapest$296Average$386FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$366Average$436FlexibilityNo cancel feeOn-time69%

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