$204+ Cheap flights from Des Moines to Myrtle Beach (DSM - MYR)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/16. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MYR
Apr 12 — Apr 191
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Myrtle Beach with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Myrtle Beach
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Last-minute
One-way
Cheapest flights from Des Moines to Myrtle BeachExplore the most affordable flight options available from Des Moines to Myrtle Beach. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 13, 2026.
Explore the most affordable flight options available from Des Moines to Myrtle Beach. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 13, 2026.
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:00 am
DSM
- MYR
1 stop5h 15m
American Airlines
Sat 5/22:30 pm
MYR
- DSM
1 stop6h 03m
American Airlines
Deal found 3/11![American Airlines logo]()
$327
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/293:57 pm
DSM
- MYR
1 stop6h 32m
Multiple Airlines
Sun 5/318:31 pm
MYR
- DSM
1 stop18h 29m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$330
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:00 am
DSM
- MYR
1 stop4h 35m
American Airlines
Sat 5/165:00 am
MYR
- DSM
2 stops7h 30m
American Airlines
Deal found 3/9![American Airlines logo]()
$332
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/276:20 am
DSM
- MYR
1 stop6h 57m
United Airlines
Sat 5/23:14 pm
MYR
- DSM
1 stop7h 11m
United Airlines
Deal found 3/8![United Airlines logo]()
$335
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:20 am
DSM
- MYR
1 stop6h 57m
United Airlines
Sat 5/23:14 pm
MYR
- DSM
1 stop7h 11m
United Airlines
Deal found 3/11![United Airlines logo]()
$337
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:02 am
DSM
- MYR
1 stop5h 26m
American Airlines
Tue 6/166:21 pm
MYR
- DSM
1 stop6h 29m
American Airlines
Deal found 3/9![American Airlines logo]()
$353
Best flights from Des Moines to Myrtle BeachDiscover carefully curated flight deals from Des Moines to Myrtle Beach that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 13, 2026.
Discover carefully curated flight deals from Des Moines to Myrtle Beach that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 13, 2026.
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/276:20 am
DSM
- MYR
2 stops9h 42m
United Airlines
Sat 5/23:14 pm
MYR
- DSM
1 stop7h 11m
United Airlines
Deal found 3/8![United Airlines logo]()
$340
This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/256:41 pm
DSM
- MYR
1 stop4h 16m
Delta
Thu 5/286:00 am
MYR
- DSM
1 stop6h 08m
Delta
Deal found 3/8![Delta logo]()
$361
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/91:37 pm
DSM
- MYR
1 stop7h 10m
American Airlines
Tue 6/166:06 pm
MYR
- DSM
1 stop7h 04m
American Airlines
Deal found 3/12![American Airlines logo]()
$363
This Southwest deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:40 am
DSM
- MYR
2 stops10h 35m
Southwest
Fri 5/810:55 am
MYR
- DSM
2 stops12h 00m
Southwest
Deal found 3/8![Southwest logo]()
$371
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:31 pm
DSM
- MYR
1 stop4h 43m
Delta
Fri 5/86:00 am
MYR
- DSM
1 stop6h 08m
Delta
Deal found 3/9![Delta logo]()
$361
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/98:00 am
DSM
- MYR
1 stop5h 18m
United Airlines
Tue 5/123:14 pm
MYR
- DSM
1 stop7h 09m
United Airlines
Deal found 3/11![United Airlines logo]()
$397
This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/95:45 am
DSM
- MYR
1 stop5h 34m
Delta
Tue 6/166:00 am
MYR
- DSM
1 stop5h 14m
Delta
Deal found 3/8![Delta logo]()
$361
This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/286:30 pm
DSM
- MYR
1 stop4h 08m
Delta
Thu 7/306:00 am
MYR
- DSM
1 stop5h 14m
Delta
Deal found 3/8![Delta logo]()
$387
This Delta deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/310:15 am
DSM
- MYR
1 stop5h 01m
Delta
Tue 7/710:55 am
MYR
- DSM
2 stops10h 50m
Delta
Deal found 3/8![Delta logo]()
$392
Last-minute flights from Des Moines to Myrtle BeachDiscover last-minute flight deals from Des Moines to Myrtle Beach. Data last updated March 13, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Myrtle Beach. Data last updated March 13, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:00 am
DSM
- MYR
1 stop4h 39m
American Airlines
Sun 4/59:14 am
MYR
- DSM
1 stop4h 53m
American Airlines
Deal found 3/8![American Airlines logo]()
$371
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:20 am
DSM
- MYR
1 stop6h 57m
United Airlines
Mon 4/63:15 pm
MYR
- DSM
1 stop7h 17m
United Airlines
Deal found 3/11![United Airlines logo]()
$355
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/115:35 am
DSM
- MYR
1 stop4h 30m
Southwest
Mon 4/1310:55 am
MYR
- DSM
2 stops13h 10m
Southwest
Deal found 3/10![Southwest logo]()
$356
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/276:20 am
DSM
- MYR
1 stop6h 57m
United Airlines
Sat 5/23:14 pm
MYR
- DSM
1 stop7h 11m
United Airlines
Deal found 3/8![United Airlines logo]()
$335
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:00 am
DSM
- MYR
1 stop5h 15m
American Airlines
Sat 5/22:30 pm
MYR
- DSM
1 stop6h 03m
American Airlines
Deal found 3/11![American Airlines logo]()
$327
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:20 am
DSM
- MYR
1 stop6h 57m
United Airlines
Sat 5/23:14 pm
MYR
- DSM
1 stop7h 11m
United Airlines
Deal found 3/11![United Airlines logo]()
$337
One-way flights from Des Moines to Myrtle BeachSearch for one-way flight options from Des Moines to Myrtle Beach. Find affordable one-way fares based on user searches. Data last updated March 13, 2026.
Search for one-way flight options from Des Moines to Myrtle Beach. Find affordable one-way fares based on user searches. Data last updated March 13, 2026.
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:30 pm
DSM
- MYR
1 stop4h 08m
Delta
Deal found 3/12![Delta logo]()
$204
This Southwest deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:25 am
DSM
- MYR
2 stops11h 00m
Southwest
Deal found 3/12![Southwest logo]()
$209
Find flight deals from Des Moines to Myrtle Beach
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Myrtle Beach (MYR). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $327 (American Airlines) |
One-way from | $204 (Delta) |
Popular in | November |
Cheapest in | January |
Average price | $400 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Myrtle Beach that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 13, 2026.
Use the filters below to find and compare flights from Des Moines to Myrtle Beach that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Mon 4/27
6:20 am-5:02 pm
2 stops9h 42m
Myrtle Beach Intl
Sat 5/2
3:14 pm-9:25 pm
1 stop7h 11m
$340
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Mon 5/25
6:41 pm-11:57 pm
1 stop4h 16m
Myrtle Beach Intl
Thu 5/28
6:00 am-11:08 am
1 stop6h 08m
$361
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Mon 5/4
6:31 pm-12:14 am
1 stop4h 43m
Myrtle Beach Intl
Fri 5/8
6:00 am-11:08 am
1 stop6h 08m
$361
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Tue 6/9
5:45 am-12:19 pm
1 stop5h 34m
Myrtle Beach Intl
Tue 6/16
6:00 am-10:14 am
1 stop5h 14m
$361
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Tue 6/9
1:37 pm-9:47 pm
1 stop7h 10m
Myrtle Beach Intl
Tue 6/16
6:06 pm-12:10 am
1 stop7h 04m
$363
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Sat 5/2
6:40 am-6:15 pm
2 stops10h 35m
Myrtle Beach Intl
Fri 5/8
10:55 am-9:55 pm
2 stops12h 00m
$371
Quickest round-trip
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Tue 7/28
6:30 pm-11:38 pm
1 stop4h 08m
Myrtle Beach Intl
Thu 7/30
6:00 am-10:14 am
1 stop5h 14m
$387
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Fri 7/3
10:15 am-4:16 pm
1 stop5h 01m
Myrtle Beach Intl
Tue 7/7
10:55 am-8:45 pm
2 stops10h 50m
$392
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Sat 5/9
8:00 am-2:18 pm
1 stop5h 18m
Myrtle Beach Intl
Tue 5/12
3:14 pm-9:23 pm
1 stop7h 09m
$397
Cheapest one-way
Quickest one-way
Des MoinesMyrtle Beach
DSM - MYR
DSMMYR
Des Moines
Tue 6/16
6:30 pm-11:38 pm
1 stop4h 08m
$204
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Myrtle Beach
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Myrtle Beach in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Myrtle Beach flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Myrtle Beach flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Myrtle Beach flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Myrtle Beach flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Myrtle Beach flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Myrtle Beach
Have a flexible travel schedule? Discover the best time to fly to Myrtle Beach from Des Moines with our price prediction graph.
DSM-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Myrtle Beach
Reviews of airlines servicing Myrtle Beach
Get insights into the airlines that provide service to Myrtle Beach. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Myrtle Beach. Reviews last updated March 13, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to Myrtle Beach have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Overall
8.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Overall
8.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Overall
8.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Overall
8.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Entertainment
7.5
Overall
8.0
Comfort
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Myrtle Beach. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Myrtle Beach?
Book flights to Myrtle Beach if you plan to visit one of these locationsConway
Surfside Beach
Pawleys Island
Little River
Ocean Isle Beach
Garden City Beach
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Complete your trip to Myrtle Beach by adding a car rental and/or hotel reservation to your travel itinerary.
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Other flights to Myrtle Beach
Explore flights to Myrtle Beach departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 13, 2026.
Des Moines and Myrtle Beach flights
Browse other Des Moines and Myrtle Beach flight options. Last updated on March 13, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on March 13, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from Des Moines to Myrtle Beach
Discover the top 4 airlines that operate flights from Des Moines to Myrtle Beach. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$385 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$272 | Average$404 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$299 | Average$386 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$386 | Average$436 | FlexibilityNo cancel fee | On-time69% |