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$324+ Cheap flights from Florence, SC (FLO) to Mexico

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/3. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — MEX
Mar 17 — Mar 241
Tue 3/17
Tue 3/24
1 adult, Economy
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Cheap flight deals from Florence to Mexico

Cheapest flights from Florence to Mexico
Explore the most affordable flight options available from Florence to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 15, 2026.

This American Airlines deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/315:58 pm
FLO
-
CUN
2 stops18h 13m
American Airlines
Tue 4/73:07 pm
CUN
-
FLO
2 stops23h 43m
American Airlines
Deal found 2/14$519
This American Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:16 am
FLO
-
SJD
2 stops11h 32m
American Airlines
Wed 4/81:46 pm
SJD
-
FLO
2 stops23h 04m
American Airlines
Deal found 2/15$577
This American Airlines deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/265:20 am
FLO
-
CUN
1 stop8h 20m
American Airlines
Sat 5/23:32 pm
CUN
-
FLO
1 stop7h 20m
American Airlines
Deal found 2/14$581
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:25 pm
FLO
-
CUN
2 stops16h 02m
American Airlines
Sat 4/410:30 am
CUN
-
FLO
2 stops12h 27m
American Airlines
Deal found 2/11$600
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:09 am
FLO
-
CUN
1 stop6h 53m
American Airlines
Thu 7/1612:12 pm
CUN
-
FLO
1 stop10h 44m
American Airlines
Deal found 2/12$608
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/42:36 pm
FLO
-
CUN
2 stops19h 54m
American Airlines
Tue 7/144:30 pm
CUN
-
FLO
2 stops20h 41m
American Airlines
Deal found 2/12$612
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/42:36 pm
FLO
-
CUN
1 stop23h 59m
American Airlines
Thu 7/1612:12 pm
CUN
-
FLO
1 stop10h 44m
American Airlines
Deal found 2/12$614
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:09 am
FLO
-
CUN
1 stop6h 53m
American Airlines
Mon 7/1310:35 am
CUN
-
FLO
1 stop12h 21m
American Airlines
Deal found 2/11$653
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/32:36 pm
FLO
-
CUN
2 stops20h 24m
American Airlines
Wed 7/152:07 pm
CUN
-
FLO
2 stops8h 49m
American Airlines
Deal found 2/11$657
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/25:09 am
FLO
-
CUN
1 stop5h 26m
American Airlines
Wed 7/153:35 pm
CUN
-
FLO
1 stop7h 21m
American Airlines
Deal found 2/11$689

Find flight deals from Florence to Mexico

Keep the following information in mind while searching for Florence to Mexico flight deals. Data was last updated February 15, 2026.

Round-trip from

$519
(American Airlines)

One-way from

$324
(American Airlines)
From Florence to Mexico
Search Deals
One-way flight from Florence to Mexico
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 15, 2026.
Use the filters below to find and compare flights from Florence to Mexico that are best for you.

Fly from

Florence

Fly to

Mexico

Route

Depart

Return

Price

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Tue 3/31

5:58 pm-11:11 am

2 stops18h 13m

Cancun

Tue 4/7

3:07 pm-3:50 pm

2 stops23h 43m

$519

FlorenceSan José del Cabo

FLO - SJD

FLOSJD

Florence

Wed 4/1

5:16 am-1:48 pm

2 stops11h 32m

San José del Cabo Los Cabos

Wed 4/8

1:46 pm-3:50 pm

2 stops23h 04m

$577

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Sun 4/26

5:20 am-12:40 pm

1 stop8h 20m

Cancun

Sat 5/2

3:32 pm-11:52 pm

1 stop7h 20m

$581

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Sat 3/28

6:25 pm-9:27 am

2 stops16h 02m

Cancun

Sat 4/4

10:30 am-11:57 pm

2 stops12h 27m

$600

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Wed 7/1

5:09 am-11:02 am

1 stop6h 53m

Cancun

Thu 7/16

12:12 pm-11:56 pm

1 stop10h 44m

$608

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Wed 7/1

5:09 am-11:02 am

1 stop6h 53m

Cancun

Wed 7/15

4:00 pm-2:11 pm

2 stops21h 11m

$612

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Sat 7/4

2:36 pm-11:29 am

2 stops21h 53m

Cancun

Wed 7/15

12:29 pm-11:56 pm

2 stops10h 27m

$612

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Sat 7/4

2:36 pm-1:35 pm

1 stop23h 59m

Cancun

Tue 7/14

2:35 pm-11:56 pm

1 stop8h 21m

$614

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Sat 7/4

2:36 pm-1:35 pm

1 stop23h 59m

Cancun

Thu 7/16

12:12 pm-11:56 pm

1 stop10h 44m

$614

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Fri 4/3

6:20 pm-9:27 am

2 stops16h 07m

$324

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/11

Best time to book a flight from Florence to Mexico

Have a flexible travel schedule? Discover the best time to fly to Mexico from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to Mexico

What is the cheapest month to book a flight from Florence, South Carolina to Mexico?

Currently, February is the cheapest month in which you can book a flight from Florence, South Carolina to Mexico (average of $122). Flying from Florence, South Carolina to Mexico in March is currently the most expensive (average of $228). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Florence to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Florence to Mexico?

    Florence (FLO), located 2.3 mi from the city center, is the airport you fly out of when you book flights from Florence to Mexico.

  • How long is the flight from Florence, South Carolina to Mexico?

    For as low as $519, American Airlines can have you in Mexico from Florence, South Carolina in 18h 13m. Airlines will cover a distance of 1007 mi.

  • What are the most popular routes from Florence, South Carolina to Mexico?

    The most popular route from Florence, South Carolina to Mexico is Florence - Cancun. You may also consider Florence - Puerto Vallarta Ordaz or Florence - San José del Cabo Los Cabos.

  • Can I find deals for flights from Florence to Mexico that include hotel bookings?

    Yes. In addition to deals on Florence to Mexico flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to Mexico?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to Mexico.

  • Can I find deals for business class flights from Florence to Mexico?

    Yes. Cheapflights offers flight deals from Florence to Mexico by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florence, South Carolina to Mexico?

    Currently, February is the cheapest month in which you can book a flight from Florence, South Carolina to Mexico (average of $122). Flying from Florence, South Carolina to Mexico in March is currently the most expensive (average of $228). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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