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$536+ Cheap flights from Florence, SC (FLO) to Mexico

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/3. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — MEX
Feb 27 — Mar 61
Fri 2/27
Fri 3/6
1 adult, Economy
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Cheap flight deals from Florence to Mexico

Cheapest flights from Florence to Mexico
Explore the most affordable flight options available from Florence to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.

This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/36:15 am
FLO
-
CUN
1 stop6h 01m
American Airlines
Sun 3/812:17 pm
CUN
-
FLO
1 stop10h 40m
American Airlines
Deal found 1/27$536
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/125:16 am
FLO
-
CUN
1 stop8h 59m
American Airlines
Thu 3/191:25 pm
CUN
-
FLO
1 stop9h 32m
American Airlines
Deal found 1/26$584
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:22 am
FLO
-
SJD
2 stops12h 03m
American Airlines
Wed 10/1412:30 pm
SJD
-
FLO
2 stops18h 56m
American Airlines
Deal found 1/26$675
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/72:17 pm
FLO
-
SJD
2 stops25h 08m
American Airlines
Wed 10/143:40 pm
SJD
-
FLO
2 stops15h 46m
American Airlines
Deal found 1/26$720
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:22 am
FLO
-
SJD
2 stops12h 03m
American Airlines
Sun 10/183:40 pm
SJD
-
FLO
2 stops29h 23m
American Airlines
Deal found 1/26$725
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/112:17 pm
FLO
-
SJD
2 stops21h 51m
American Airlines
Thu 10/154:30 pm
SJD
-
FLO
2 stops18h 39m
American Airlines
Deal found 1/26$735
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/122:17 pm
FLO
-
SJD
2 stops22h 33m
American Airlines
Mon 10/194:30 pm
SJD
-
FLO
2 stops18h 39m
American Airlines
Deal found 1/26$739
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/112:17 pm
FLO
-
SJD
2 stops25h 08m
American Airlines
Sun 10/182:10 pm
SJD
-
FLO
2 stops20h 59m
American Airlines
Deal found 1/26$740
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/92:17 pm
FLO
-
SJD
2 stops22h 33m
American Airlines
Tue 10/132:10 pm
SJD
-
FLO
2 stops17h 16m
American Airlines
Deal found 1/26$741
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/102:17 pm
FLO
-
SJD
2 stops21h 51m
American Airlines
Sun 10/184:30 pm
SJD
-
FLO
2 stops38h 56m
American Airlines
Deal found 1/26$746
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/112:17 pm
FLO
-
SJD
2 stops25h 08m
American Airlines
Tue 10/132:10 pm
SJD
-
FLO
2 stops17h 16m
American Airlines
Deal found 1/26$751
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/122:17 pm
FLO
-
SJD
2 stops22h 33m
American Airlines
Wed 10/142:35 pm
SJD
-
FLO
2 stops16h 51m
American Airlines
Deal found 1/26$755

Find flight deals from Florence to Mexico

Keep the following information in mind while searching for Florence to Mexico flight deals. Data was last updated January 28, 2026.

Round-trip from

$536
(American Airlines)
From Florence to Mexico
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Florence to Mexico that are best for you.

Fly from

Florence

Fly to

Mexico

Route

Depart

Return

Price

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Tue 3/3

6:15 am-12:16 pm

1 stop6h 01m

Cancun

Sun 3/8

12:17 pm-11:57 pm

1 stop10h 40m

$536

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Thu 3/12

5:16 am-1:15 pm

1 stop8h 59m

Cancun

Thu 3/19

1:25 pm-11:57 pm

1 stop9h 32m

$584

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Sat 4/4

6:25 pm-9:45 am

2 stops16h 20m

Cancun

Sat 4/11

4:25 pm-3:50 pm

2 stops22h 25m

$925

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Best time to book a flight from Florence to Mexico

Have a flexible travel schedule? Discover the best time to fly to Mexico from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to Mexico

What is the cheapest month to book a flight from Florence, South Carolina to Mexico?

Currently, February is the cheapest month in which you can book a flight from Florence, South Carolina to Mexico (average of $122). Flying from Florence, South Carolina to Mexico in December is currently the most expensive (average of $236). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Florence to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Florence to Mexico?

    Florence (FLO), located 2.3 mi from the city center, is the airport you fly out of when you book flights from Florence to Mexico.

  • How long is the flight from Florence, South Carolina to Mexico?

    For as low as $536, American Airlines can have you in Mexico from Florence, South Carolina in 6h 01m. Airlines will cover a distance of 1007 mi.

  • What are the most popular routes from Florence, South Carolina to Mexico?

    The most popular route from Florence, South Carolina to Mexico is Florence - Cancun. You may also consider Florence - Puerto Vallarta Ordaz or Florence - San José del Cabo Los Cabos.

  • Can I find deals for flights from Florence to Mexico that include hotel bookings?

    Yes. In addition to deals on Florence to Mexico flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to Mexico?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to Mexico.

  • Can I find deals for business class flights from Florence to Mexico?

    Yes. Cheapflights offers flight deals from Florence to Mexico by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florence, South Carolina to Mexico?

    Currently, February is the cheapest month in which you can book a flight from Florence, South Carolina to Mexico (average of $122). Flying from Florence, South Carolina to Mexico in December is currently the most expensive (average of $236). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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