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$325+ Cheap flights from Florence, SC (FLO) to Mexico

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/12. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — MEX
Dec 13 — Dec 201
Sat 12/13
Sat 12/20
1 adult, Economy
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Find flight deals from Florence to Mexico

Cheapest flights from Florence to Mexico
Explore the most affordable flight options available from Florence to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.

This American Airlines deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/185:15 amFLO - CUN
1 stop5h 18mAmerican Airlines
Sun 12/2111:35 amCUN - FLO
1 stop12h 40mAmerican Airlines
Deal found 11/13$657

Cheap flight deals from Florence to Mexico

Keep the following information in mind while searching for Florence to Mexico flight deals. Data was last updated November 13, 2025.

Round-trip from

$487
(American Airlines)

One-way from

$325
(American Airlines)
From Florence to Mexico
Search Deals
One-way flight from Florence to Mexico
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Florence to Mexico that are best for you.

Fly from

Florence

Fly to

Mexico

Route

Depart

Return

Price

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Sun 11/30

5:15 am-12:15 pm

1 stop7h 00m

Cancun

Fri 12/12

1:16 pm-10:53 pm

1 stop9h 37m

$487

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Tue 12/2

6:15 am-2:12 pm

1 stop7h 57m

Cancun

Fri 12/12

1:16 pm-10:53 pm

1 stop9h 37m

$487

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Tue 12/2

10:29 am-4:11 pm

1 stop5h 42m

Cancun

Thu 12/11

5:07 pm-9:50 am

2 stops16h 43m

$491

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Thu 12/4

6:31 pm-12:08 pm

2 stops17h 37m

Cancun

Tue 12/9

11:50 am-10:53 pm

2 stops11h 03m

$491

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Sun 11/30

5:15 am-2:10 pm

1 stop8h 55m

Cancun

Tue 12/9

11:50 am-10:53 pm

2 stops11h 03m

$491

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Mon 12/1

6:33 pm-10:45 am

2 stops16h 12m

Cancun

Thu 12/11

3:08 pm-9:50 am

2 stops18h 42m

$491

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Fri 12/5

6:15 am-4:12 pm

1 stop9h 57m

Cancun

Fri 12/12

11:31 am-10:53 pm

2 stops11h 22m

$491

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Sun 11/30

5:15 am-2:10 pm

1 stop8h 55m

Cancun

Thu 12/11

5:07 pm-9:50 am

2 stops16h 43m

$491

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Thu 12/4

6:31 pm-12:08 pm

2 stops17h 37m

Cancun

Wed 12/10

11:50 am-10:53 pm

2 stops11h 03m

$491

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Sat 12/6

6:31 pm-10:32 am

1 stop16h 01m

Cancun

Tue 12/9

11:50 am-10:53 pm

2 stops11h 03m

$491

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/13

Showing 1-10 of 14 results
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Best time to book a flight from Florence to Mexico

Have a flexible travel schedule? Discover the best time to fly to Mexico from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to Mexico

What is the cheapest month to book a flight from Florence, South Carolina to Mexico?

Currently, January is the cheapest month in which you can book a flight from Florence, South Carolina to Mexico (average of $117). Flying from Florence, South Carolina to Mexico in March is currently the most expensive (average of $269). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Florence to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Florence to Mexico?

    Florence (FLO), located 2.3 mi from the city center, is the airport you fly out of when you book flights from Florence to Mexico.

  • How long is the flight from Florence, South Carolina to Mexico?

    For as low as $487, American Airlines can have you in Mexico from Florence, South Carolina in 7h. Airlines will cover a distance of 1007 mi.

  • What are the most popular routes from Florence, South Carolina to Mexico?

    The most popular route from Florence, South Carolina to Mexico is Florence - Cancun. You may also consider Florence - Puerto Vallarta Ordaz or Florence - San José del Cabo Los Cabos.

  • Can I find deals for flights from Florence to Mexico that include hotel bookings?

    Yes. In addition to deals on Florence to Mexico flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to Mexico?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to Mexico.

  • Can I find deals for business class flights from Florence to Mexico?

    Yes. Cheapflights offers flight deals from Florence to Mexico by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florence, South Carolina to Mexico?

    Currently, January is the cheapest month in which you can book a flight from Florence, South Carolina to Mexico (average of $117). Flying from Florence, South Carolina to Mexico in March is currently the most expensive (average of $269). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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