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$518+ Cheap flights from Florence, SC (FLO) to Mexico

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/14. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — MEX
Mar 30 — Apr 61
Mon 3/30
Mon 4/6
1 adult, Economy
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Cheap flight deals from Florence to Mexico

Cheapest flights from Florence to Mexico
Explore the most affordable flight options available from Florence to Mexico. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 28, 2026.

This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:15 am
FLO
-
CUN
1 stop5h 55m
American Airlines
Tue 4/2112:10 pm
CUN
-
FLO
1 stop9h 32m
American Airlines
Deal found 2/28$518
This American Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/265:20 am
FLO
-
CUN
1 stop10h 12m
American Airlines
Sat 5/212:10 pm
CUN
-
FLO
1 stop10h 42m
American Airlines
Deal found 2/26$601
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:09 am
FLO
-
CUN
1 stop6h 53m
American Airlines
Tue 7/142:35 pm
CUN
-
FLO
1 stop8h 21m
American Airlines
Deal found 2/25$628
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:09 am
FLO
-
CUN
1 stop9h 26m
American Airlines
Mon 7/1312:12 pm
CUN
-
FLO
1 stop10h 44m
American Airlines
Deal found 2/25$663
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:09 am
FLO
-
CUN
1 stop10h 25m
American Airlines
Tue 7/143:35 pm
CUN
-
FLO
1 stop7h 21m
American Airlines
Deal found 2/25$675
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:09 am
FLO
-
CUN
1 stop10h 25m
American Airlines
Wed 7/1512:29 pm
CUN
-
FLO
2 stops10h 27m
American Airlines
Deal found 2/25$679
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:09 am
FLO
-
CUN
1 stop5h 22m
American Airlines
Sun 7/1210:35 am
CUN
-
FLO
1 stop12h 21m
American Airlines
Deal found 2/25$680

Find flight deals from Florence to Mexico

Keep the following information in mind while searching for Florence to Mexico flight deals. Data was last updated February 28, 2026.

Round-trip from

$518
(American Airlines)
From Florence to Mexico
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to Mexico that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 28, 2026.
Use the filters below to find and compare flights from Florence to Mexico that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Fri 4/10

5:20 am-3:25 pm

2 stops11h 05m

Cancun

Fri 4/17

11:01 am-11:52 pm

2 stops11h 51m

$557

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Sun 4/26

5:20 am-2:32 pm

1 stop10h 12m

Cancun

Sat 5/2

12:10 pm-11:52 pm

1 stop10h 42m

$601

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Wed 7/1

5:09 am-3:25 pm

2 stops11h 16m

Cancun

Mon 7/13

11:30 am-11:56 pm

2 stops11h 26m

$667

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Fri 7/3

5:09 am-2:34 pm

1 stop10h 25m

Cancun

Tue 7/14

3:35 pm-11:56 pm

1 stop7h 21m

$675

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Fri 7/3

5:09 am-1:35 pm

1 stop9h 26m

Cancun

Wed 7/15

10:35 am-11:56 pm

1 stop12h 21m

$675

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Fri 7/3

5:09 am-1:35 pm

1 stop9h 26m

Cancun

Mon 7/13

11:30 am-11:56 pm

2 stops11h 26m

$714

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Thu 7/2

5:09 am-10:00 am

2 stops29h 51m

Cancun

Fri 7/10

12:12 pm-2:11 pm

1 stop24h 59m

$775

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Sat 4/4

6:25 pm-9:27 am

2 stops16h 02m

Cancun

Sat 4/11

11:01 am-11:52 pm

2 stops11h 51m

$858

FlorenceCancún

FLO - CUN

FLOCUN

Florence

Fri 4/3

6:20 pm-9:27 am

2 stops16h 07m

Cancun

Sat 4/11

11:35 am-11:52 pm

2 stops11h 17m

$893

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/24

Sorted by cheapest first

Best time to book a flight from Florence to Mexico

Have a flexible travel schedule? Discover the best time to fly to Mexico from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to Mexico

What is the cheapest month to book a flight from Florence, South Carolina to Mexico?

Currently, February is the cheapest month in which you can book a flight from Florence, South Carolina to Mexico (average of $122). Flying from Florence, South Carolina to Mexico in March is currently the most expensive (average of $230). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Florence to Mexico. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Florence to Mexico?

    Florence (FLO), located 2.3 mi from the city center, is the airport you fly out of when you book flights from Florence to Mexico.

  • How long is the flight from Florence, South Carolina to Mexico?

    For as low as $557, American Airlines can have you in Mexico from Florence, South Carolina in 11h 05m. Airlines will cover a distance of 1007 mi.

  • What are the most popular routes from Florence, South Carolina to Mexico?

    The most popular route from Florence, South Carolina to Mexico is Florence - Cancun. You may also consider Florence - Puerto Vallarta Ordaz or Florence - San José del Cabo Los Cabos.

  • Can I find deals for flights from Florence to Mexico that include hotel bookings?

    Yes. In addition to deals on Florence to Mexico flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to Mexico?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to Mexico.

  • Can I find deals for business class flights from Florence to Mexico?

    Yes. Cheapflights offers flight deals from Florence to Mexico by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florence, South Carolina to Mexico?

    Currently, February is the cheapest month in which you can book a flight from Florence, South Carolina to Mexico (average of $122). Flying from Florence, South Carolina to Mexico in March is currently the most expensive (average of $230). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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