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$168+ Cheap flights from Des Moines to Jacksonville (DSM - JAX)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/19. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — JAX
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to Jacksonville are usually found in October or August, booked 49 days in advance, depart on a Monday or Tuesday and return on a Monday

Cheap flight deals from Des Moines to Jacksonville

Cheapest flights from Des Moines to Jacksonville
Explore the most affordable flight options available from Des Moines to Jacksonville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/312:10 pm
DSM
-
JAX
2 stops24h 36m
Allegiant Air
Thu 6/49:21 pm
JAX
-
DSM
Nonstop2h 37m
Allegiant Air
Deal found 1/28$250
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/293:57 pm
DSM
-
JAX
2 stops45h 28m
Multiple Airlines
Sun 6/78:20 pm
JAX
-
DSM
Nonstop2h 37m
Multiple Airlines
Deal found 1/28$302
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/282:10 pm
DSM
-
JAX
2 stops24h 36m
Allegiant Air
Sun 6/78:20 pm
JAX
-
DSM
Nonstop2h 37m
Allegiant Air
Deal found 1/28$304
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/19:51 pm
DSM
-
JAX
3 stops35h 01m
Multiple Airlines
Sun 6/78:20 pm
JAX
-
DSM
Nonstop2h 37m
Multiple Airlines
Deal found 1/28$320
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/211:29 pm
DSM
-
JAX
1 stop6h 46m
United Airlines
Wed 2/257:45 am
JAX
-
DSM
1 stop7h 42m
United Airlines
Deal found 1/28$336
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/215:00 am
DSM
-
JAX
2 stops6h 32m
American Airlines
Wed 2/256:00 am
JAX
-
DSM
2 stops8h 05m
American Airlines
Deal found 1/28$346
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/252:59 pm
DSM
-
JAX
1 stop5h 33m
United Airlines
Mon 3/25:31 pm
JAX
-
DSM
1 stop5h 49m
United Airlines
Deal found 1/28$347
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/255:00 am
DSM
-
JAX
2 stops9h 10m
American Airlines
Mon 3/23:55 pm
JAX
-
DSM
2 stops8h 45m
American Airlines
Deal found 1/28$357
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/93:28 pm
DSM
-
JAX
1 stop5h 04m
United Airlines
Thu 3/126:00 am
JAX
-
DSM
1 stop5h 30m
United Airlines
Deal found 1/27$359
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/24:25 pm
DSM
-
JAX
2 stops40h 34m
Allegiant Air
Sun 6/78:20 pm
JAX
-
DSM
Nonstop2h 37m
Allegiant Air
Deal found 1/28$363

Find flight deals from Des Moines to Jacksonville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Jacksonville (JAX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$250
(Kiwi.com)

One-way from

$168
(Delta)

Popular in

March

Cheapest in

October

Average price

$395

Good one-way deal

$277 or less
Provider with most accurate pricing for Des Moines-Jacksonville flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Jacksonville flights.
Search Deals
From Des Moines to Jacksonville
Search Deals
One-way flight from Des Moines to Jacksonville
Search Deals
Highest demand for flights based on searches. 33% potential increase in price ($129 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals
Price to beat on a one-way flight from Des Moines to Jacksonville.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Jacksonville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Des Moines to Jacksonville that are best for you.

Fly from

Des Moines

Fly to

Jacksonville

Route

Depart

Return

Price

Des MoinesJacksonville

DSM - JAX

DSMJAX

Des Moines

Sat 2/21

1:29 pm-9:15 pm

1 stop6h 46m

Jacksonville

Wed 2/25

7:45 am-2:27 pm

1 stop7h 42m

$336

Des MoinesJacksonville

DSM - JAX

DSMJAX

Des Moines

Tue 3/10

3:40 pm-9:15 pm

1 stop4h 35m

Jacksonville

Thu 3/12

6:40 am-12:10 pm

1 stop6h 30m

$347

Des MoinesJacksonville

DSM - JAX

DSMJAX

Des Moines

Wed 2/25

2:59 pm-9:32 pm

1 stop5h 33m

Jacksonville

Mon 3/2

5:31 pm-10:20 pm

1 stop5h 49m

$347

Des MoinesJacksonville

DSM - JAX

DSMJAX

Des Moines

Tue 3/10

8:00 am-2:12 pm

1 stop5h 12m

Jacksonville

Thu 3/12

8:00 am-2:24 pm

1 stop7h 24m

$347

Des MoinesJacksonville

DSM - JAX

DSMJAX

Des Moines

Sat 4/4

11:33 am-4:23 pm

1 stop3h 50m

Jacksonville

Sat 4/11

5:28 pm-10:38 pm

1 stop6h 10m

$359

Des MoinesJacksonville

DSM - JAX

DSMJAX

Des Moines

Mon 3/9

4:20 pm-10:05 pm

1 stop4h 45m

Jacksonville

Thu 3/12

6:40 am-12:10 pm

1 stop6h 30m

$359

Des MoinesJacksonville

DSM - JAX

DSMJAX

Des Moines

Tue 5/19

6:30 pm-12:02 am

1 stop4h 32m

$168

Des MoinesJacksonville

DSM - JAX

DSMJAX

Des Moines

Mon 5/18

4:20 pm-10:05 pm

1 stop4h 45m

$180

Des MoinesJacksonville

DSM - JAX

DSMJAX

Des Moines

Thu 2/5

4:30 pm-4:23 pm

3 stops46h 53m

$228

Des MoinesJacksonville

DSM - JAX

DSMJAX

Des Moines

Fri 2/13

5:15 pm-12:01 am

1 stop5h 46m

$244

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/28

Showing 1-10 of 16 results
1
2

Compare providers for flights from Des Moines to Jacksonville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Jacksonville in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
MytripPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Jacksonville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Jacksonville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Jacksonville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Jacksonville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Jacksonville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Jacksonville

Have a flexible travel schedule? Discover the best time to fly to Jacksonville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Jacksonville

How far ahead should I book a flight from Des Moines to Jacksonville?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Jacksonville. Price data was last updated on January 23, 2026.

The price you pay for your flight from Des Moines to Jacksonville may vary depending on when you book. For the best chance of a lower fare, look to book 49 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Des Moines to Jacksonville?

Currently, October is the cheapest month in which you can book a flight from Des Moines to Jacksonville (average of $42). Flying from Des Moines to Jacksonville in March is currently the most expensive (average of $353). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Jacksonville

Get insights into the airlines that provide service to Jacksonville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Jacksonville. Reviews last updated January 29, 2026.
Read reviews from past customers who have flown Southwest, Delta, and American Airlines from Des Moines to Jacksonville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,267 reviews

Comfort

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,267 reviews
Southwest
8.0
Very good
4,267 reviews

Comfort

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,127 reviews
Southwest
8.0
Very good
4,267 reviews

Comfort

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,206 reviews
Southwest
8.0
Very good
4,267 reviews

Comfort

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Allegiant Air
7.2
Good
706 reviews
Southwest
8.0
Very good
4,267 reviews

Comfort

8.0

Crew

8.6

Boarding

8.1

Food

7.0

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Jacksonville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Des Moines to Jacksonville flight route?

    This flight path from Des Moines to Jacksonville was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Des Moines to Jacksonville?

    For as low as $336, Allegiant Air can have you in Jacksonville from Des Moines in 6h 46m. The distance between Des Moines and Jacksonville is about 1012 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Des Moines to Jacksonville round-trip?

    Cheapflights users have booked flights from Des Moines to Jacksonville round-trip from $62. Other airlines that can offer you cheap pricing are Delta, from $154, and American Airlines, from $216. These flights start at 75% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to Jacksonville one-way?

    $38 is the cheapest one-way deal found within the past few days, from Allegiant Air. You may also be able to find cheap deals on American Airlines and Delta, with prices starting from $154 and $158, respectively.

  • What are the cheapest flights from Des Moines to Jacksonville?

    The cheapest flight price from Des Moines to Jacksonville is $277. On average you can expect to pay $277. The most popular route, (Des Moines - Jacksonville), can usually be booked for $237.

  • Can I find deals for flights from Des Moines to Jacksonville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Jacksonville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Jacksonville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Jacksonville.

  • Can I find deals for business class flights from Des Moines to Jacksonville?

    Yes. Cheapflights offers flight deals from Des Moines to Jacksonville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Jacksonville?

    Currently, October is the cheapest month in which you can book a flight from Des Moines to Jacksonville (average of $42). Flying from Des Moines to Jacksonville in March is currently the most expensive (average of $353). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Jacksonville?

Book flights to Jacksonville if you plan to visit one of these locations
Jacksonville Beach
Orange Park
Fernandina Beach
Kingsland
Waycross
Yulee

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Top 4 airlines flying from Des Moines to Jacksonville

Discover the top 4 airlines that operate flights from Des Moines to Jacksonville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$62Average$93FlexibilityNo cancel feeOn-time88%
DeltaCheapest$154Average$382FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$216Average$381FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$308Average$396FlexibilityNo cancel feeOn-time63%

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