$138+ Cheap flights from Des Moines to Jacksonville (DSM - JAX)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/5. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — JAX
Feb 25 — Mar 41
1 adult, Economy
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Find cheap flights from Des Moines to Jacksonville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Des Moines to Jacksonville are usually found in October or August, booked 49 days in advance, depart on a Monday or Tuesday and return on a Monday
Cheap flight deals from Des Moines to Jacksonville
Cheapest flights from Des Moines to JacksonvilleExplore the most affordable flight options available from Des Moines to Jacksonville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 26, 2026.
Explore the most affordable flight options available from Des Moines to Jacksonville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 26, 2026.
This United Airlines deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/211:29 pm
DSM
- JAX
1 stop6h 46m
United Airlines
Sat 2/287:45 am
JAX
- DSM
1 stop7h 42m
United Airlines
Deal found 1/24![United Airlines logo]()
$337
This American Airlines deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/215:00 am
DSM
- JAX
2 stops6h 32m
American Airlines
Sat 2/287:00 am
JAX
- DSM
1 stop7h 05m
American Airlines
Deal found 1/24![American Airlines logo]()
$342
This United Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/251:32 pm
DSM
- JAX
1 stop6h 43m
United Airlines
Sat 3/73:07 pm
JAX
- DSM
2 stops9h 35m
United Airlines
Deal found 1/25![United Airlines logo]()
$353
This Southwest deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/223:15 pm
DSM
- JAX
1 stop5h 00m
Southwest
Tue 4/287:20 am
JAX
- DSM
1 stop5h 05m
Southwest
Deal found 1/25![Southwest logo]()
$359
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/165:00 am
DSM
- JAX
2 stops9h 05m
American Airlines
Thu 2/197:00 am
JAX
- DSM
1 stop7h 05m
American Airlines
Deal found 1/25![American Airlines logo]()
$364
This American Airlines deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/267:00 am
DSM
- JAX
1 stop7h 05m
American Airlines
Sat 3/283:55 pm
JAX
- DSM
1 stop7h 04m
American Airlines
Deal found 1/24![American Airlines logo]()
$365
This American Airlines deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:00 am
DSM
- JAX
2 stops8h 01m
American Airlines
Mon 5/42:22 pm
JAX
- DSM
1 stop8h 31m
American Airlines
Deal found 1/24![American Airlines logo]()
$377
This American Airlines deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/55:00 am
DSM
- JAX
2 stops6h 53m
American Airlines
Mon 3/93:55 pm
JAX
- DSM
2 stops8h 45m
American Airlines
Deal found 1/24![American Airlines logo]()
$378
This American Airlines deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/235:00 am
DSM
- JAX
2 stops9h 05m
American Airlines
Mon 3/93:55 pm
JAX
- DSM
2 stops8h 45m
American Airlines
Deal found 1/24![American Airlines logo]()
$380
Find flight deals from Des Moines to Jacksonville
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Jacksonville (JAX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 26, 2026.
Most accurate provider | Mytrip 3 stars |
|---|---|
Most trusted provider | Mytrip 3 stars |
Round-trip from | $337 (United Airlines) |
One-way from | $138 (Kiwi.com) |
Popular in | March |
Cheapest in | October |
Average price | $395 |
Good one-way deal | $277 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Jacksonville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
Use the filters below to find and compare flights from Des Moines to Jacksonville that are best for you.
Fly from
Des Moines
Fly to
Jacksonville
Route
Depart
Return
Price
Des MoinesJacksonville
DSM - JAX
DSMJAX
Des Moines
Sat 2/21
5:00 am-3:05 pm
2 stops9h 05m
Jacksonville
Sat 2/28
3:55 pm-11:40 pm
2 stops8h 45m
$348
Des MoinesJacksonville
DSM - JAX
DSMJAX
Des Moines
Thu 2/26
7:52 am-4:25 pm
1 stop7h 33m
Jacksonville
Sat 2/28
5:22 pm-10:15 pm
1 stop5h 53m
$348
Des MoinesJacksonville
DSM - JAX
DSMJAX
Des Moines
Wed 2/25
3:24 pm-9:24 pm
1 stop5h 00m
Jacksonville
Sat 3/7
5:47 pm-10:44 pm
1 stop5h 57m
$348
Des MoinesJacksonville
DSM - JAX
DSMJAX
Des Moines
Wed 2/25
6:10 am-6:10 pm
2 stops11h 00m
Jacksonville
Sat 3/7
6:25 pm-10:50 pm
1 stop5h 25m
$353
Des MoinesJacksonville
DSM - JAX
DSMJAX
Des Moines
Sat 4/25
6:30 pm-11:59 pm
1 stop4h 29m
Jacksonville
Tue 5/5
6:59 pm-10:34 pm
1 stop4h 35m
$359
Des MoinesJacksonville
DSM - JAX
DSMJAX
Des Moines
Mon 2/16
6:00 am-1:49 pm
1 stop6h 49m
Jacksonville
Thu 2/19
2:29 pm-9:51 pm
1 stop8h 22m
$359
Des MoinesJacksonville
DSM - JAX
DSMJAX
Des Moines
Wed 4/22
7:00 am-2:11 pm
1 stop6h 11m
Jacksonville
Sat 5/2
7:30 am-11:05 am
1 stop4h 35m
$359
Des MoinesJacksonville
DSM - JAX
DSMJAX
Des Moines
Sat 4/25
6:40 am-4:10 pm
1 stop8h 30m
Jacksonville
Sat 5/2
5:10 am-1:30 pm
1 stop9h 20m
$359
Des MoinesJacksonville
DSM - JAX
DSMJAX
Des Moines
Wed 4/22
2:44 pm-10:50 pm
1 stop7h 06m
Jacksonville
Wed 4/29
5:30 am-11:05 am
1 stop6h 35m
$359
Des MoinesJacksonville
DSM - JAX
DSMJAX
Des Moines
Mon 3/2
3:24 pm-9:24 pm
1 stop5h 00m
Jacksonville
Mon 3/9
5:22 pm-10:44 pm
1 stop6h 22m
$359
Showing 1-10 of 24 results
Compare providers for flights from Des Moines to Jacksonville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Jacksonville in January.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*1 star | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Jacksonville flights, users find the pricing of Mytrip to be most consistent on Cheapflights vs. Mytrip Users can find the same prices on Des Moines-Jacksonville flight deals on Cheapflights vs. Mytrip >95% of the time. Price accuracy is based on data collected from Des Moines-Jacksonville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Jacksonville flights, Cheapflights users trust Mytrip the most. Mytrip has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Jacksonville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Jacksonville
Have a flexible travel schedule? Discover the best time to fly to Jacksonville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Jacksonville
Prices
More
How far ahead should I book a flight from Des Moines to Jacksonville?
Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Jacksonville. Price data was last updated on January 23, 2026.
The price you pay for your flight from Des Moines to Jacksonville may vary depending on when you book. For the best chance of a lower fare, look to book 49 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Des Moines to Jacksonville?
Currently, October is the cheapest month in which you can book a flight from Des Moines to Jacksonville (average of $42). Flying from Des Moines to Jacksonville in March is currently the most expensive (average of $353). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What’s the top layover airport for flights from Des Moines to Jacksonville?
Share of 1-stop round-trip flights from Des Moines to Jacksonville chosen by Cheapflights users in the past 12 months, using the same layover each way.
Dallas (DFW) – chosen by Cheapflights users on 50% of 1-stop itineraries from Des Moines to Jacksonville on Cheapflights.
What’s the cheapest layover airport for flights from Des Moines to Jacksonville?
Average round-trip fare for 1-stop flights from Des Moines to Jacksonville, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Dallas (DFW) is the most affordable 1-stop option, with an average round-trip price of $276.
What’s the fastest layover option from Des Moines to Jacksonville?
Shortest average travel time for 1-stop one-way flights from Des Moines to Jacksonville, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via St. Louis (STL) have the shortest average one-way travel time for 1-stop routes: 4h 00m.
Which airport typically offers the quickest layover for flights from Des Moines to Jacksonville?
Average layover duration for 1-stop one-way flights from Des Moines to Jacksonville, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via St. Louis (STL) offer the fastest connection on this route, with an average layover time of 1h 15m.
Reviews of airlines servicing Jacksonville
Get insights into the airlines that provide service to Jacksonville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Jacksonville. Reviews last updated January 26, 2026.
Read reviews from past customers who have flown Southwest, Delta, and American Airlines from Des Moines to Jacksonville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Boarding
8.1
Overall
8.0
Crew
8.6
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Entertainment
7.5
Boarding
8.1
Overall
8.0
Crew
8.6
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Entertainment
7.5
Boarding
8.1
Overall
8.0
Crew
8.6
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Entertainment
7.5
Boarding
8.1
Overall
8.0
Crew
8.6
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Entertainment
7.5
Boarding
8.1
Overall
8.0
Crew
8.6
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Jacksonville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Jacksonville?
Book flights to Jacksonville if you plan to visit one of these locationsJacksonville Beach
Orange Park
Fernandina Beach
Kingsland
Waycross
Yulee
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Alternative routes for Des Moines to Jacksonville
See prices for flight routes from nearby airports that may be better suited for you.
Top 4 airlines flying from Des Moines to Jacksonville
Discover the top 4 airlines that operate flights from Des Moines to Jacksonville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$62 | Average$93 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$154 | Average$382 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$216 | Average$381 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$308 | Average$396 | FlexibilityNo cancel fee | On-time63% |