$145+ Cheap flights from Des Moines to Jacksonville (DSM - JAX)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/8. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — JAX
Sep 10 — Sep 171
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Jacksonville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Des Moines to Jacksonville are usually found in October or November, booked 55 days in advance, depart on a Wednesday or Monday and return on a Monday
Cheap flight deals from Des Moines to Jacksonville
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to JacksonvilleExplore the most affordable flight options available from Des Moines to Jacksonville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 11, 2026.
Explore the most affordable flight options available from Des Moines to Jacksonville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 11, 2026.
This Delta deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/286:54 pm -
1 stop4h 04m
Sat 10/310:45 am -
1 stop5h 30m
Deal found 8/10![Delta logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/61:58 pm -
2 stops27h 12m
Thu 9/109:15 am -
1 stop11h 42m
Deal found 8/9![Multiple Airlines logo]()
$285
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/285:40 am -
2 stops7h 40m
Sat 10/34:55 pm -
1 stop4h 50m
Deal found 8/10![Southwest logo]()
$286
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1512:25 pm -
1 stop19h 15m
Wed 11/183:50 pm -
1 stop25h 21m
Deal found 8/7![Multiple Airlines logo]()
$290
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:50 am -
2 stops11h 30m
Thu 10/296:35 am -
2 stops7h 45m
Deal found 8/10![Southwest logo]()
$298
This Southwest deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/66:05 am -
1 stop9h 50m
Thu 9/107:00 am -
1 stop5h 25m
Deal found 8/9![Southwest logo]()
$316
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:00 am -
1 stop7h 04m
Mon 9/77:30 am -
1 stop7h 46m
Deal found 8/10![United Airlines logo]()
$329
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:45 pm -
2 stops24h 35m
Sun 10/43:00 pm -
1 stop6h 53m
Deal found 8/9![Multiple Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/292:44 pm -
1 stop6h 56m
Sun 10/48:24 pm -
1 stop4h 28m
Deal found 8/10![American Airlines logo]()
$359
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/85:42 pm -
1 stop13h 43m
Mon 10/126:46 pm -
2 stops42h 09m
Deal found 8/9![Multiple Airlines logo]()
$360
Best flights from Des Moines to JacksonvilleDiscover carefully curated flight deals from Des Moines to Jacksonville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 11, 2026.
Discover carefully curated flight deals from Des Moines to Jacksonville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 11, 2026.
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/108:00 am -
1 stop5h 05m
Sat 9/197:15 am -
1 stop6h 01m
Deal found 8/11![United Airlines logo]()
$371
This Delta deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/510:59 am -
1 stop4h 53m
Tue 9/86:00 am -
1 stop5h 46m
Deal found 8/8![Delta logo]()
$388
This Southwest deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/215:40 am -
2 stops8h 35m
Wed 9/236:15 am -
2 stops8h 40m
Deal found 8/7![Southwest logo]()
$395
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:05 am -
2 stops7h 58m
Thu 11/59:20 am -
2 stops9h 03m
Deal found 8/10![United Airlines logo]()
$382
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/213:22 pm -
1 stop6h 58m
Wed 9/234:45 pm -
1 stop5h 42m
Deal found 8/7![United Airlines logo]()
$385
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/93:03 pm -
1 stop5h 44m
Sun 10/115:49 pm -
1 stop5h 44m
Deal found 8/9![Delta logo]()
$437
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:40 am -
2 stops9h 15m
Fri 10/23:00 pm -
2 stops8h 55m
Deal found 8/11![Southwest logo]()
$438
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/911:31 am -
1 stop6h 51m
Mon 9/1411:59 am -
1 stop6h 20m
Deal found 8/9![Delta logo]()
$437
This Southwest deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:50 am -
2 stops11h 00m
Thu 10/291:30 pm -
2 stops9h 25m
Deal found 8/9![Southwest logo]()
$447
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/45:45 am -
1 stop8h 57m
Tue 10/612:40 pm -
2 stops12h 08m
Deal found 8/10![United Airlines logo]()
$454
Last-minute flights from Des Moines to JacksonvilleDiscover last-minute flight deals from Des Moines to Jacksonville. Data last updated August 11, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Jacksonville. Data last updated August 11, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:00 am -
1 stop7h 04m
Mon 9/77:30 am -
1 stop7h 46m
Deal found 8/10![United Airlines logo]()
$329
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/61:58 pm -
2 stops27h 12m
Thu 9/109:15 am -
1 stop11h 42m
Deal found 8/9![Multiple Airlines logo]()
$285
This Southwest deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/66:05 am -
1 stop9h 50m
Thu 9/107:00 am -
1 stop5h 25m
Deal found 8/9![Southwest logo]()
$316
This American Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:44 pm -
1 stop6h 56m
Wed 9/166:00 am -
1 stop7h 04m
Deal found 8/11![American Airlines logo]()
$281
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/103:50 pm -
1 stop5h 15m
Wed 9/161:40 pm -
2 stops9h 20m
Deal found 8/11![Southwest logo]()
$286
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/253:50 pm -
1 stop5h 15m
Fri 10/23:00 pm -
2 stops8h 55m
Deal found 8/11![Southwest logo]()
$365
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/292:44 pm -
1 stop6h 56m
Sun 10/48:24 pm -
1 stop4h 28m
Deal found 8/10![American Airlines logo]()
$359
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:10 am -
2 stops9h 35m
Sun 10/47:45 am -
1 stop4h 35m
Deal found 8/10![Southwest logo]()
$364
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:45 pm -
2 stops24h 35m
Sun 10/43:00 pm -
1 stop6h 53m
Deal found 8/9![Multiple Airlines logo]()
$339
One-way flights from Des Moines to JacksonvilleSearch for one-way flight options from Des Moines to Jacksonville. Find affordable one-way fares based on user searches. Data last updated August 11, 2026.
Search for one-way flight options from Des Moines to Jacksonville. Find affordable one-way fares based on user searches. Data last updated August 11, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/88:43 am -
2 stops32h 08m
Deal found 8/9![Multiple Airlines logo]()
$145
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/64:11 pm -
1 stop6h 44m
Deal found 8/9![Delta logo]()
$170
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/97:57 pm -
2 stops20h 54m
Deal found 8/9![Multiple Airlines logo]()
$188
This Delta deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1811:28 am -
1 stop6h 36m
Deal found 8/7![Delta logo]()
$193
This Southwest deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:00 am -
2 stops10h 00m
Deal found 8/7![Southwest logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/198:45 am -
1 stop22h 55m
Deal found 8/7![Multiple Airlines logo]()
$206
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/93:03 pm -
1 stop5h 44m
Deal found 8/9![Delta logo]()
$219
This Southwest deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/66:05 am -
2 stops8h 45m
Deal found 8/9![Southwest logo]()
$220
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:05 am -
2 stops10h 28m
Deal found 8/7![United Airlines logo]()
$243
This Delta deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/225:40 am -
1 stop6h 56m
Deal found 8/8![Delta logo]()
$259
Find flight deals from Des Moines to Jacksonville
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Jacksonville (JAX). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $281 (Delta) |
One-way from | $145 (Kiwi.com) |
Popular in | March |
Cheapest in | October |
Average price | $172 |
Good round-trip deal | $86 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Jacksonville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 11, 2026.
Use the filters below to find and compare flights from Des Moines to Jacksonville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesJacksonville
DSM Des Moines - JAX Jacksonville
DSMJAX
Des Moines
Thu 9/10
8:00 am-2:05 pm
1 stop5h 05m
Jacksonville
Sat 9/19
7:15 am-12:16 pm
1 stop6h 01m
$371
Des MoinesJacksonville
DSM Des Moines - JAX Jacksonville
DSMJAX
Des Moines
Mon 11/2
6:05 am-3:03 pm
2 stops7h 58m
Jacksonville
Thu 11/5
9:20 am-5:23 pm
2 stops9h 03m
$382
Des MoinesJacksonville
DSM Des Moines - JAX Jacksonville
DSMJAX
Des Moines
Mon 9/21
3:22 pm-11:20 pm
1 stop6h 58m
Jacksonville
Wed 9/23
4:45 pm-9:27 pm
1 stop5h 42m
$385
Quickest round-trip
Des MoinesJacksonville
DSM Des Moines - JAX Jacksonville
DSMJAX
Des Moines
Sat 9/5
10:59 am-4:52 pm
1 stop4h 53m
Jacksonville
Tue 9/8
6:00 am-10:46 am
1 stop5h 46m
$388
Des MoinesJacksonville
DSM Des Moines - JAX Jacksonville
DSMJAX
Des Moines
Mon 9/21
5:40 am-3:15 pm
2 stops8h 35m
Jacksonville
Wed 9/23
6:15 am-1:55 pm
2 stops8h 40m
$395
Des MoinesJacksonville
DSM Des Moines - JAX Jacksonville
DSMJAX
Des Moines
Fri 10/9
3:03 pm-9:47 pm
1 stop5h 44m
Jacksonville
Sun 10/11
5:49 pm-10:33 pm
1 stop5h 44m
$437
Des MoinesJacksonville
DSM Des Moines - JAX Jacksonville
DSMJAX
Des Moines
Wed 9/9
11:31 am-7:22 pm
1 stop6h 51m
Jacksonville
Mon 9/14
11:59 am-5:19 pm
1 stop6h 20m
$437
Des MoinesJacksonville
DSM Des Moines - JAX Jacksonville
DSMJAX
Des Moines
Fri 9/25
5:40 am-3:55 pm
2 stops9h 15m
Jacksonville
Fri 10/2
3:00 pm-10:55 pm
2 stops8h 55m
$438
Des MoinesJacksonville
DSM Des Moines - JAX Jacksonville
DSMJAX
Des Moines
Sat 10/24
5:50 am-5:50 pm
2 stops11h 00m
Jacksonville
Thu 10/29
1:30 pm-9:55 pm
2 stops9h 25m
$447
Des MoinesJacksonville
DSM Des Moines - JAX Jacksonville
DSMJAX
Des Moines
Sun 10/4
5:45 am-3:42 pm
1 stop8h 57m
Jacksonville
Tue 10/6
12:40 pm-11:48 pm
2 stops12h 08m
$454
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Jacksonville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Jacksonville in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Jacksonville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Jacksonville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Jacksonville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Jacksonville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Jacksonville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Jacksonville
Have a flexible travel schedule? Discover the best time to fly to Jacksonville from Des Moines with our price prediction graph.
DSM-JAX
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Jacksonville
Prices
More
How far ahead should I book a flight from Des Moines to Jacksonville?
The price you pay for your flight from Des Moines to Jacksonville may vary depending on when you book. For the best chance of a lower fare, look to book 44 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Des Moines to Jacksonville?
Currently, October is the cheapest month in which you can book a flight from Des Moines to Jacksonville (average of $93). Flying from Des Moines to Jacksonville in March is currently the most expensive (average of $455). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Jacksonville?
Airfare is typical for this route at the moment.
Des Moines to Jacksonville flights typically cost between $100 and $453 in September.The cheapest round-trip price found within the last 5 days was $281 on Delta (Sep 28-Oct 3).
What’s the top layover airport for flights from Des Moines to Jacksonville?
Share of 1-stop round-trip flights from Des Moines to Jacksonville chosen by Cheapflights users in the past 12 months, using the same layover each way.
Dallas (DFW) – chosen by Cheapflights users on 50% of 1-stop itineraries from Des Moines to Jacksonville on Cheapflights.
What’s the cheapest layover airport for flights from Des Moines to Jacksonville?
Average round-trip fare for 1-stop flights from Des Moines to Jacksonville, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Dallas (DFW) is the most affordable 1-stop option, with an average round-trip price of $276.
What’s the fastest layover option from Des Moines to Jacksonville?
Shortest average travel time for 1-stop one-way flights from Des Moines to Jacksonville, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via St. Louis (STL) have the shortest average one-way travel time for 1-stop routes: 4h 00m.
Which airport typically offers the quickest layover for flights from Des Moines to Jacksonville?
Average layover duration for 1-stop one-way flights from Des Moines to Jacksonville, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via St. Louis (STL) offer the fastest connection on this route, with an average layover time of 1h 15m.
Reviews of airlines servicing Jacksonville
Get insights into the airlines that provide service to Jacksonville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Jacksonville. Reviews last updated August 11, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Des Moines to Jacksonville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.6
Food
7.0
Overall
8.0
Entertainment
7.5
Comfort
8.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Boarding
8.1
Crew
8.6
Food
7.0
Overall
8.0
Entertainment
7.5
Comfort
8.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Boarding
8.1
Crew
8.6
Food
7.0
Overall
8.0
Entertainment
7.5
Comfort
8.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Boarding
8.1
Crew
8.6
Food
7.0
Overall
8.0
Entertainment
7.5
Comfort
8.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Boarding
8.1
Crew
8.6
Food
7.0
Overall
8.0
Entertainment
7.5
Comfort
8.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Boarding
8.1
Crew
8.6
Food
7.0
Overall
8.0
Entertainment
7.5
Comfort
8.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Jacksonville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Book flights to Jacksonville if you plan to visit one of these locationsJacksonville Beach
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Top 5 airlines flying from Des Moines to Jacksonville
Discover the top 5 airlines that operate flights from Des Moines to Jacksonville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$56 | Average$108 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$180 | Average$396 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$203 | Average$427 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$222 | Average$407 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$373 | Average$452 | FlexibilityNo cancel fee | On-time63% |