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$105+ Cheap flights from Myrtle Beach to Indianapolis (MYR - IND)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/12. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — IND
Jan 22 — Jan 291
Thu 1/22
Thu 1/29
1 adult, Economy
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Cheap flight deals from Myrtle Beach to Indianapolis

Cheapest flights from Myrtle Beach to Indianapolis
Explore the most affordable flight options available from Myrtle Beach to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 23, 2025.

This CheapOair deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/286:00 amMYR - IND
1 stop9h 56mSpirit Airlines
Sun 1/44:51 pmIND - MYR
1 stop7h 08mSpirit Airlines
Deal found 12/21$344
This CheapOair deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/286:00 amMYR - IND
1 stop9h 56mSpirit Airlines
Thu 1/14:51 pmIND - MYR
1 stop7h 08mSpirit Airlines
Deal found 12/21$363
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2811:00 amMYR - IND
1 stop5h 36mAmerican Airlines
Thu 1/17:39 amIND - MYR
2 stops6h 25mAmerican Airlines
Deal found 12/21$456
This Priceline deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:00 amMYR - IND
1 stop9h 56mSpirit Airlines
Fri 12/264:51 pmIND - MYR
1 stop7h 08mSpirit Airlines
Deal found 12/20$488
This Mytrip deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:00 amMYR - IND
2 stops16h 43mMultiple Airlines
Tue 12/238:48 amIND - MYR
1 stop11h 42mMultiple Airlines
Deal found 12/21$527
This Mytrip deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/227:13 pmMYR - IND
1 stop12h 00mSpirit Airlines
Tue 12/234:51 pmIND - MYR
1 stop7h 08mSpirit Airlines
Deal found 12/21$551
This Priceline deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:00 amMYR - IND
1 stop9h 56mSpirit Airlines
Mon 12/294:51 pmIND - MYR
1 stop7h 08mSpirit Airlines
Deal found 12/21$602
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/286:00 amMYR - IND
2 stops7h 18mAmerican Airlines
Sun 1/411:02 amIND - MYR
1 stop4h 34mAmerican Airlines
Deal found 12/21$626

Find flight deals from Myrtle Beach to Indianapolis

Discover tips and strategies to find the most affordable flight options for your journey from Myrtle Beach (MYR) to Indianapolis (IND). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 23, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$208
(Kiwi.com)

One-way from

$105
(Cheapflightsfares)

Popular in

March

Cheapest in

August

Average price

$356

Good one-way deal

$119 or less
Provider with most accurate pricing for Myrtle Beach Intl-Indianapolis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Indianapolis flights.
Search Deals
From Myrtle Beach Intl to Indianapolis
Search Deals
One-way flight from Myrtle Beach Intl to Indianapolis
Search Deals
Highest demand for flights based on searches. 29% potential increase in price ($160 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 9% potential price decrease ($34 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals
Price to beat on a one-way flight from Myrtle Beach Intl to Indianapolis.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Myrtle Beach to Indianapolis that are best for you.

Fly from

Myrtle Beach

Fly to

Indianapolis

Route

Depart

Return

Price

Myrtle BeachIndianapolis

MYR - IND

MYRIND

Myrtle Beach Intl

Fri 1/23

10:00 am-11:26 am

1 stop25h 26m

Indianapolis

Sun 1/25

6:55 am-2:42 pm

1 stop7h 47m

$208

Myrtle BeachIndianapolis

MYR - IND

MYRIND

Myrtle Beach Intl

Fri 1/23

10:00 am-12:18 am

1 stop14h 18m

Indianapolis

Sun 1/25

9:34 pm-7:20 pm

2 stops21h 46m

$221

Myrtle BeachIndianapolis

MYR - IND

MYRIND

Myrtle Beach Intl

Wed 1/7

6:00 am-3:56 pm

1 stop9h 56m

Indianapolis

Sun 1/11

3:01 pm-7:20 pm

1 stop28h 19m

$231

Myrtle BeachIndianapolis

MYR - IND

MYRIND

Myrtle Beach Intl

Wed 1/7

6:00 am-3:56 pm

1 stop9h 56m

Indianapolis

Sun 1/11

8:26 pm-2:42 pm

2 stops18h 16m

$254

Myrtle BeachIndianapolis

MYR - IND

MYRIND

Myrtle Beach Intl

Thu 1/22

1:25 pm-6:55 pm

1 stop5h 30m

Indianapolis

Mon 1/26

6:00 am-12:41 pm

1 stop6h 41m

$373

Myrtle BeachIndianapolis

MYR - IND

MYRIND

Myrtle Beach Intl

Fri 1/23

11:05 am-8:10 pm

2 stops9h 05m

Indianapolis

Sun 1/25

12:45 pm-9:05 pm

2 stops8h 20m

$377

Myrtle BeachIndianapolis

MYR - IND

MYRIND

Myrtle Beach Intl

Thu 2/12

9:09 am-7:23 pm

1 stop10h 14m

$105

Myrtle BeachIndianapolis

MYR - IND

MYRIND

Myrtle Beach Intl

Tue 3/31

6:00 am-10:47 am

1 stop4h 47m

$184

Myrtle BeachIndianapolis

MYR - IND

MYRIND

Myrtle Beach Intl

Tue 3/31

12:09 pm-5:58 pm

1 stop5h 49m

$184

Myrtle BeachIndianapolis

MYR - IND

MYRIND

Myrtle Beach Intl

Thu 2/12

1:00 pm-11:44 pm

2 stops10h 44m

$355

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/21

Showing 1-10 of 11 results
1
2

Compare providers for flights from Myrtle Beach to Indianapolis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Myrtle Beach to Indianapolis in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Myrtle Beach-Indianapolis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Myrtle Beach-Indianapolis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Myrtle Beach-Indianapolis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Myrtle Beach-Indianapolis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Myrtle Beach-Indianapolis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Myrtle Beach to Indianapolis

Have a flexible travel schedule? Discover the best time to fly to Indianapolis from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to Indianapolis

What is the cheapest month to book a flight from Myrtle Beach to Indianapolis?

Currently, October is the cheapest month in which you can book a flight from Myrtle Beach to Indianapolis (average of $40). Flying from Myrtle Beach to Indianapolis in January is currently the most expensive (average of $98). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MYR to IND?

Find hourly flight availability from Myrtle Beach to Indianapolis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 23, 2025.

One of the essential ways to save on airfare from Myrtle Beach to Indianapolis is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the morning could potentially save you up to 70% on airfare.

Reviews of airlines servicing Indianapolis

Get insights into the airlines that provide service to Indianapolis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indianapolis. Reviews last updated December 23, 2025.
Read reviews from past customers who have flown Delta, American Airlines, and Spirit Airlines from Myrtle Beach to Indianapolis. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,013 reviews

Entertainment

7.9

Overall

7.9

Boarding

8.1

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,013 reviews
Delta
7.9
Good
8,013 reviews

Entertainment

7.9

Overall

7.9

Boarding

8.1

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,054 reviews
Delta
7.9
Good
8,013 reviews

Entertainment

7.9

Overall

7.9

Boarding

8.1

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Spirit Airlines
6.3
Okay
8,195 reviews
Delta
7.9
Good
8,013 reviews

Entertainment

7.9

Overall

7.9

Boarding

8.1

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to Indianapolis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Myrtle Beach to Indianapolis?

    There are many flights that can get you from Myrtle Beach to Indianapolis in 25h 26m. Fly via Spirit Airlines to get the fastest option. The distance from Myrtle Beach to Indianapolis is about 583 mi.

  • What are the cheapest airlines flying from Myrtle Beach to Indianapolis round-trip?

    Our cheapest airline available from Myrtle Beach to Indianapolis is Spirit Airlines. Our recent data shows that you can find tickets from as low as $83 on this airline. Additional options worth looking into are American Airlines and Delta, starting at $271 and $286 round-trip. Spirit Airlines is currently priced 78% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Myrtle Beach to Indianapolis one-way?

    For one-way options, check prices for Allegiant Air. According to our data, you can fly for as low as $38. Users have also found prices from $75 and $140 on Spirit Airlines and American Airlines, respectively.

  • What are the cheapest flights from Myrtle Beach to Indianapolis?

    Looking at all options, your cheapest flight can be booked for $94. While the most popular route (Myrtle Beach Intl - Indianapolis) can be booked for $330 on average, our data indicates $119 when flying from Myrtle Beach to Indianapolis.

  • Can I find deals for flights from Myrtle Beach to Indianapolis that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to Indianapolis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to Indianapolis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to Indianapolis.

  • Can I find deals for business class flights from Myrtle Beach to Indianapolis?

    Yes. Cheapflights offers flight deals from Myrtle Beach to Indianapolis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Myrtle Beach to Indianapolis?

    Currently, October is the cheapest month in which you can book a flight from Myrtle Beach to Indianapolis (average of $40). Flying from Myrtle Beach to Indianapolis in January is currently the most expensive (average of $98). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Terre Haute
Muncie
Noblesville
Fishers
Greenwood
Plainfield
Anderson
Kokomo
Franklin
Carmel
Crawfordsville
Bloomington
Speedway

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Top 3 airlines flying from Myrtle Beach to Indianapolis

Discover the top 3 airlines that operate flights from Myrtle Beach to Indianapolis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$146Average$174FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$271Average$412FlexibilityNo cancel feeOn-time71%
DeltaCheapest$286Average$416FlexibilityNo cancel feeOn-timeN/A

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