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$72+ Cheap flights from Des Moines (DSM) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/23. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Cheap flight deals from Des Moines to Florida Keys

Keep the following information in mind while searching for Des Moines to Florida Keys flight deals. Data was last updated November 6, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$179
(Southwest)

One-way from

$72
(Priceline)

Popular in

March

Cheapest in

June

Average price

$413
Provider with most accurate pricing for Des Moines-Miami flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Miami flights.
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From Des Moines to Florida Keys
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One-way flight from Des Moines to Florida Keys
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Highest demand for flights based on searches. 10% potential increase in price ($50 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Des Moines to Florida Keys

Cheapest flights from Des Moines to Florida Keys
Explore the most affordable flight options available from Des Moines to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/158:20 amDSM - MIA
1 stop6h 40mSouthwest
Wed 12/244:55 pmMIA - DSM
1 stop5h 40mSouthwest
Deal found 11/5$179
This Southwest deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/26:15 amDSM - MIA
1 stop5h 10mSouthwest
Thu 12/44:55 pmMIA - DSM
1 stop5h 40mSouthwest
Deal found 11/6$199
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/26:00 amDSM - MIA
Nonstop3h 22mAmerican Airlines
Tue 12/98:50 pmMIA - DSM
Nonstop3h 39mAmerican Airlines
Deal found 11/5$214
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:33 pmDSM - MIA
1 stop5h 13mDelta
Wed 12/105:00 pmMIA - DSM
1 stop6h 34mDelta
Deal found 11/4$217
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/248:00 amDSM - MIA
1 stop9h 45mSouthwest
Fri 12/54:55 pmMIA - DSM
1 stop5h 40mSouthwest
Deal found 11/5$224
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/42:56 pmDSM - MIA
2 stops26h 51mMultiple Airlines
Thu 12/119:03 pmMIA - DSM
1 stop16h 52mMultiple Airlines
Deal found 11/5$242
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/156:00 amDSM - MIA
Nonstop3h 28mAmerican Airlines
Wed 12/249:05 pmMIA - DSM
Nonstop3h 43mAmerican Airlines
Deal found 11/5$244
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/610:38 amDSM - EYW
1 stop28h 06mAllegiant Air
Thu 12/1110:27 pmEYW - DSM
1 stop25h 45mAllegiant Air
Deal found 11/5$246
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/46:00 amDSM - MIA
Nonstop3h 28mAmerican Airlines
Tue 12/98:50 pmMIA - DSM
Nonstop3h 39mAmerican Airlines
Deal found 11/6$252
This Expedia deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/238:19 pmDSM - MIA
1 stop7h 51mFrontier
Fri 12/126:00 amMIA - DSM
1 stop14h 03mFrontier
Deal found 11/6$253
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/66:25 amDSM - MIA
1 stop9h 05mSouthwest
Sat 12/1310:45 amMIA - DSM
1 stop5h 10mSouthwest
Deal found 11/5$254
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:00 amDSM - MIA
1 stop7h 29mAmerican Airlines
Wed 12/108:50 pmMIA - DSM
Nonstop3h 39mAmerican Airlines
Deal found 11/5$255

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Des Moines to Florida Keys that are best for you.

Fly from

Des Moines

Fly to

Florida Keys

Route

Depart

Return

Price

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Mon 12/15

8:20 am-4:00 pm

1 stop6h 40m

Miami

Wed 12/24

4:55 pm-9:35 pm

1 stop5h 40m

$179

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Mon 11/24

8:00 am-6:45 pm

1 stop9h 45m

Miami

Fri 12/5

4:55 pm-9:35 pm

1 stop5h 40m

$189

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 12/3

6:33 pm-12:46 am

1 stop5h 13m

Miami

Wed 12/10

5:00 pm-10:34 pm

1 stop6h 34m

$217

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 12/6

10:38 am-3:44 pm

1 stop28h 06m

Key West

Thu 12/11

10:27 pm-11:12 pm

1 stop25h 45m

$246

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Fri 12/5

6:33 pm-12:46 am

1 stop5h 13m

Miami

Sat 12/13

7:00 am-2:12 pm

1 stop8h 12m

$259

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 1/17

7:50 am-10:20 pm

2 stops13h 30m

Miami

Sat 1/24

9:05 am-2:22 pm

1 stop6h 17m

$262

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 1/24

11:30 am-11:59 pm

2 stops11h 29m

Miami

Sat 1/31

4:51 pm-10:30 pm

1 stop6h 39m

$262

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 12/2

8:20 am-4:00 pm

1 stop6h 40m

Miami

Thu 12/4

11:40 am-9:35 pm

2 stops10h 55m

$264

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 1/14

6:00 am-4:07 pm

1 stop9h 07m

Key West

Wed 1/21

6:43 pm-11:08 pm

1 stop5h 25m

$269

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 12/6

11:23 am-8:06 pm

1 stop7h 43m

Key West

Sat 12/13

6:10 pm-10:34 pm

1 stop5h 24m

$269

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/5

Showing 1-10 of 28 results
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Best time to book a flight from Des Moines to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Florida Keys

What is the cheapest month to book a flight from Des Moines to Florida Keys?

Currently, July is the cheapest month in which you can book a flight from Des Moines to Florida Keys (average of $82). Flying from Des Moines to Florida Keys in August is currently the most expensive (average of $324). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated November 6, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Des Moines to Florida Keys. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Comfort

8.0

Boarding

8.1

Overall

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Comfort

8.0

Boarding

8.1

Overall

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
8,001 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Comfort

8.0

Boarding

8.1

Overall

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
9,007 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Comfort

8.0

Boarding

8.1

Overall

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,040 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Comfort

8.0

Boarding

8.1

Overall

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Allegiant Air
7.2
Good
697 reviews
Southwest
8.0
Very good
4,241 reviews

Food

7.0

Comfort

8.0

Boarding

8.1

Overall

8.0

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Florida Keys?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Florida Keys.

  • How long is the flight from Des Moines to Florida Keys?

    Departing from Des Moines to Florida Keys will take you 5h 13m. There are 1328 mi between Des Moines and Florida Keys. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Des Moines to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Des Moines to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Florida Keys.

  • Can I find deals for business class flights from Des Moines to Florida Keys?

    Yes. Cheapflights offers flight deals from Des Moines to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Florida Keys?

    Currently, July is the cheapest month in which you can book a flight from Des Moines to Florida Keys (average of $82). Flying from Des Moines to Florida Keys in August is currently the most expensive (average of $324). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Des Moines to Florida Keys

Discover the top 4 airlines that operate flights from Des Moines to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$157FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$268Average$517FlexibilityNo cancel feeOn-time71%
DeltaCheapest$268Average$475FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$281Average$502FlexibilityNo cancel feeOn-time69%

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