$95+ Cheap flights from Des Moines (DSM) to Florida Keys
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Mar 11 — Mar 181
1 adult, Economy
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Find cheap flights from Des Moines to Florida Keys with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to Florida KeysExplore the most affordable flight options available from Des Moines to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 9, 2026.
Explore the most affordable flight options available from Des Moines to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 9, 2026.
This Frontier deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:17 pm
DSM
- MIA
1 stop8h 57m
Frontier
Thu 3/56:45 am
MIA
- DSM
1 stop12h 57m
Frontier
Deal found 2/6![Frontier logo]()
$183
This Expedia deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/227:45 pm
DSM
- MIA
1 stop8h 29m
Frontier
Thu 2/266:45 am
MIA
- DSM
1 stop12h 57m
Frontier
Deal found 2/8![Frontier logo]()
$190
This Southwest deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:30 am
DSM
- MIA
1 stop5h 25m
Southwest
Tue 4/146:40 am
MIA
- DSM
1 stop5h 45m
Southwest
Deal found 2/6![Southwest logo]()
$197
This Kiwi.com deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/78:21 pm
DSM
- MIA
1 stop7h 28m
Frontier
Tue 3/107:04 pm
MIA
- DSM
2 stops25h 12m
Frontier
Deal found 2/5![Frontier logo]()
$204
This Southwest deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:10 am
DSM
- MIA
1 stop4h 50m
Southwest
Thu 2/267:20 pm
MIA
- DSM
1 stop5h 15m
Southwest
Deal found 2/6![Southwest logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:27 pm
DSM
- MIA
1 stop8h 47m
Frontier
Sat 3/75:50 am
MIA
- DSM
1 stop14h 26m
Frontier
Deal found 2/6![Frontier logo]()
$212
This Expedia deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:17 pm
DSM
- MIA
1 stop8h 57m
Frontier
Sat 3/75:50 am
MIA
- DSM
1 stop14h 26m
Frontier
Deal found 2/6![Frontier logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:27 pm
DSM
- MIA
1 stop8h 47m
Frontier
Wed 3/115:50 am
MIA
- DSM
1 stop14h 26m
Frontier
Deal found 2/6![Frontier logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:17 pm
DSM
- MIA
2 stops39h 23m
Multiple Airlines
Sat 3/75:50 am
MIA
- DSM
1 stop14h 26m
Multiple Airlines
Deal found 2/6![Multiple Airlines logo]()
$229
This Delta deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2511:33 am
DSM
- EYW
1 stop4h 57m
Delta
Wed 4/16:25 pm
EYW
- DSM
1 stop5h 13m
Delta
Deal found 2/8![Delta logo]()
$289
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1811:09 am
DSM
- EYW
2 stops10h 27m
American Airlines
Thu 4/236:46 pm
EYW
- DSM
1 stop6h 03m
American Airlines
Deal found 2/7![American Airlines logo]()
$294
This American Airlines deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/712:00 pm
DSM
- EYW
2 stops9h 58m
American Airlines
Tue 4/146:45 am
EYW
- DSM
2 stops8h 01m
American Airlines
Deal found 2/6![American Airlines logo]()
$300
Best flights from Des Moines to Florida KeysDiscover carefully curated flight deals from Des Moines to Florida Keys that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 9, 2026.
Discover carefully curated flight deals from Des Moines to Florida Keys that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 9, 2026.
This Southwest deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:30 am
DSM
- MIA
1 stop5h 25m
Southwest
Tue 4/146:40 am
MIA
- DSM
1 stop5h 45m
Southwest
Deal found 2/6![Southwest logo]()
$197
This Delta deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2511:33 am
DSM
- EYW
1 stop7h 08m
Delta
Wed 4/16:25 pm
EYW
- DSM
1 stop5h 13m
Delta
Deal found 2/6![Delta logo]()
$289
This American Airlines deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:00 am
DSM
- EYW
1 stop8h 24m
American Airlines
Tue 4/146:49 pm
EYW
- DSM
1 stop6h 00m
American Airlines
Deal found 2/6![American Airlines logo]()
$289
This United Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:20 am
DSM
- MIA
2 stops8h 56m
United Airlines
Wed 4/87:40 am
MIA
- DSM
1 stop9h 35m
United Airlines
Deal found 2/8![United Airlines logo]()
$386
This Southwest deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/74:35 pm
DSM
- MIA
1 stop5h 25m
Southwest
Sat 3/146:25 am
MIA
- DSM
1 stop6h 05m
Southwest
Deal found 2/7![Southwest logo]()
$277
This Delta deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/76:15 am
DSM
- EYW
2 stops10h 15m
Delta
Tue 4/147:33 am
EYW
- DSM
1 stop7h 22m
Delta
Deal found 2/6![Delta logo]()
$294
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1811:09 am
DSM
- EYW
2 stops10h 27m
American Airlines
Thu 4/236:46 pm
EYW
- DSM
1 stop6h 03m
American Airlines
Deal found 2/7![American Airlines logo]()
$294
This Southwest deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/15:30 am
DSM
- MIA
1 stop5h 10m
Southwest
Wed 4/86:40 am
MIA
- DSM
1 stop5h 45m
Southwest
Deal found 2/7![Southwest logo]()
$285
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:00 am
DSM
- EYW
2 stops9h 30m
American Airlines
Tue 5/126:49 pm
EYW
- DSM
1 stop6h 00m
American Airlines
Deal found 2/7![American Airlines logo]()
$294
This Southwest deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/245:30 am
DSM
- MIA
1 stop5h 10m
Southwest
Tue 3/316:55 am
MIA
- DSM
2 stops14h 55m
Southwest
Deal found 2/7![Southwest logo]()
$290
This United Airlines deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/102:04 pm
DSM
- MIA
2 stops8h 55m
United Airlines
Wed 3/259:00 am
MIA
- DSM
1 stop6h 22m
United Airlines
Deal found 2/6![United Airlines logo]()
$386
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2511:09 am
DSM
- EYW
2 stops10h 27m
American Airlines
Sat 5/26:46 pm
EYW
- DSM
1 stop6h 03m
American Airlines
Deal found 2/8![American Airlines logo]()
$321
This Southwest deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/216:10 am
DSM
- MIA
1 stop10h 40m
Southwest
Thu 2/267:20 pm
MIA
- DSM
1 stop5h 15m
Southwest
Deal found 2/8![Southwest logo]()
$321
This Southwest deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:10 am
DSM
- MIA
2 stops11h 25m
Southwest
Sat 2/286:00 am
MIA
- DSM
1 stop5h 55m
Southwest
Deal found 2/9![Southwest logo]()
$367
This Southwest deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/115:30 am
DSM
- MIA
1 stop5h 10m
Southwest
Tue 3/176:30 am
MIA
- DSM
1 stop6h 10m
Southwest
Deal found 2/5![Southwest logo]()
$385
Last-minute flights from Des Moines to Florida KeysDiscover last-minute flight deals from Des Moines to Florida Keys. Data last updated February 9, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Florida Keys. Data last updated February 9, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/227:45 pm
DSM
- MIA
1 stop8h 29m
Frontier
Thu 2/266:45 am
MIA
- DSM
1 stop12h 57m
Frontier
Deal found 2/8![Frontier logo]()
$190
This Southwest deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:10 am
DSM
- MIA
1 stop4h 50m
Southwest
Thu 2/267:20 pm
MIA
- DSM
1 stop5h 15m
Southwest
Deal found 2/6![Southwest logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:27 pm
DSM
- MIA
1 stop8h 47m
Frontier
Sat 3/75:50 am
MIA
- DSM
1 stop14h 26m
Frontier
Deal found 2/6![Frontier logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:27 pm
DSM
- MIA
1 stop8h 47m
Frontier
Wed 3/115:50 am
MIA
- DSM
1 stop14h 26m
Frontier
Deal found 2/6![Frontier logo]()
$228
This Frontier deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:17 pm
DSM
- MIA
1 stop8h 57m
Frontier
Thu 3/56:45 am
MIA
- DSM
1 stop12h 57m
Frontier
Deal found 2/6![Frontier logo]()
$183
This Expedia deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:17 pm
DSM
- MIA
1 stop8h 57m
Frontier
Sat 3/75:50 am
MIA
- DSM
1 stop14h 26m
Frontier
Deal found 2/6![Frontier logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:17 pm
DSM
- MIA
2 stops39h 23m
Multiple Airlines
Sat 3/75:50 am
MIA
- DSM
1 stop14h 26m
Multiple Airlines
Deal found 2/6![Multiple Airlines logo]()
$229
This Kiwi.com deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/78:21 pm
DSM
- MIA
1 stop7h 28m
Frontier
Tue 3/107:04 pm
MIA
- DSM
2 stops25h 12m
Frontier
Deal found 2/5![Frontier logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/78:21 pm
DSM
- MIA
1 stop7h 28m
Frontier
Wed 3/115:50 am
MIA
- DSM
1 stop14h 26m
Frontier
Deal found 2/6![Frontier logo]()
$233
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/201:52 pm
DSM
- EYW
1 stop7h 45m
American Airlines
Tue 3/246:49 pm
EYW
- DSM
1 stop5h 51m
American Airlines
Deal found 2/7![American Airlines logo]()
$336
This Delta deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2511:33 am
DSM
- EYW
1 stop4h 57m
Delta
Wed 4/16:25 pm
EYW
- DSM
1 stop5h 13m
Delta
Deal found 2/8![Delta logo]()
$289
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/256:00 am
DSM
- EYW
2 stops8h 57m
American Airlines
Wed 4/14:40 pm
EYW
- DSM
1 stop6h 19m
American Airlines
Deal found 2/7![American Airlines logo]()
$321
One-way flights from Des Moines to Florida KeysSearch for one-way flight options from Des Moines to Florida Keys. Find affordable one-way fares based on user searches. Data last updated February 9, 2026.
Search for one-way flight options from Des Moines to Florida Keys. Find affordable one-way fares based on user searches. Data last updated February 9, 2026.
This Frontier deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/237:17 pm
DSM
- MIA
1 stop9h 31m
Frontier
Deal found 2/9![Frontier logo]()
$95
This Kiwi.com deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:21 pm
DSM
- MIA
1 stop31h 28m
Frontier
Deal found 2/6![Frontier logo]()
$96
This Southwest deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/94:20 pm
DSM
- MIA
1 stop6h 10m
Southwest
Deal found 2/7![Southwest logo]()
$99
This Frontier deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/42:20 pm
DSM
- MIA
1 stop13h 45m
Frontier
Deal found 2/6![Frontier logo]()
$101
This Kiwi.com deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/37:00 am
DSM
- MIA
1 stop13h 37m
Multiple Airlines
Deal found 2/6![Multiple Airlines logo]()
$103
This Frontier deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/98:21 pm
DSM
- MIA
1 stop8h 17m
Frontier
Deal found 2/9![Frontier logo]()
$109
This Frontier deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:17 pm
DSM
- MIA
1 stop8h 57m
Frontier
Deal found 2/6![Frontier logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/258:21 pm
DSM
- MIA
2 stops39h 23m
Frontier
Deal found 2/8![Frontier logo]()
$117
This Priceline deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/238:21 pm
DSM
- MIA
1 stop8h 17m
Frontier
Deal found 2/8![Frontier logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/216:14 pm
DSM
- EYW
1 stop15h 07m
Multiple Airlines
Deal found 2/9![Multiple Airlines logo]()
$174
This Kiwi.com deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/207:20 pm
DSM
- EYW
1 stop14h 43m
Allegiant Air
Deal found 2/7![Allegiant Air logo]()
$230
This Kiwi.com deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/207:17 pm
DSM
- EYW
2 stops36h 49m
Multiple Airlines
Deal found 2/7![Multiple Airlines logo]()
$231
Find flight deals from Des Moines to Florida Keys
Keep the following information in mind while searching for Des Moines to Florida Keys flight deals. Data was last updated February 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $183 (Frontier) |
One-way from | $95 (Frontier) |
Popular in | March |
Cheapest in | June |
Average price | $470 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 9, 2026.
Use the filters below to find and compare flights from Des Moines to Florida Keys that are best for you.
Fly from
Des Moines
Fly to
Florida Keys
Route
Depart
Return
Price
Des MoinesMiami
DSM - MIA
DSMMIA
Des Moines
Tue 4/7
5:30 am-11:55 am
1 stop5h 25m
Miami
Tue 4/14
6:40 am-11:25 am
1 stop5h 45m
$197
Des MoinesMiami
DSM - MIA
DSMMIA
Des Moines
Sat 3/7
4:35 pm-11:00 pm
1 stop5h 25m
Miami
Sat 3/14
6:25 am-11:30 am
1 stop6h 05m
$277
Des MoinesMiami
DSM - MIA
DSMMIA
Des Moines
Wed 4/1
5:30 am-11:40 am
1 stop5h 10m
Miami
Wed 4/8
6:40 am-11:25 am
1 stop5h 45m
$285
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Wed 3/25
11:33 am-7:41 pm
1 stop7h 08m
Key West
Wed 4/1
6:25 pm-10:38 pm
1 stop5h 13m
$289
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Tue 4/7
6:00 am-3:24 pm
1 stop8h 24m
Key West
Tue 4/14
6:49 pm-11:49 pm
1 stop6h 00m
$289
Des MoinesMiami
DSM - MIA
DSMMIA
Des Moines
Tue 3/24
5:30 am-11:40 am
1 stop5h 10m
Miami
Tue 3/31
6:55 am-8:50 pm
2 stops14h 55m
$290
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Tue 4/7
6:15 am-5:30 pm
2 stops10h 15m
Key West
Tue 4/14
7:33 am-1:55 pm
1 stop7h 22m
$294
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Sat 4/18
11:09 am-10:36 pm
2 stops10h 27m
Key West
Thu 4/23
6:46 pm-11:49 pm
1 stop6h 03m
$294
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Tue 5/5
6:00 am-4:30 pm
2 stops9h 30m
Key West
Tue 5/12
6:49 pm-11:49 pm
1 stop6h 00m
$294
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Sat 4/25
11:09 am-10:36 pm
2 stops10h 27m
Key West
Sat 5/2
6:46 pm-11:49 pm
1 stop6h 03m
$321
Showing 1-10 of 29 results
Best time to book a flight from Des Moines to Florida Keys
Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Des Moines with our price prediction graph.
DSM-MIA
DSM-EYW
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Florida Keys
DSM-zzEOA
DSM-MIA
DSM-EYW
What is the cheapest month to book a flight from Des Moines to Florida Keys?
Currently, July is the cheapest month in which you can book a flight from Des Moines to Florida Keys (average of $82). Flying from Des Moines to Florida Keys in December is currently the most expensive (average of $371). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Florida Keys
Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated February 9, 2026.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Des Moines to Florida Keys. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.6
Comfort
8.0
Overall
8.0
Food
7.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Crew
8.6
Comfort
8.0
Overall
8.0
Food
7.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Crew
8.6
Comfort
8.0
Overall
8.0
Food
7.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Crew
8.6
Comfort
8.0
Overall
8.0
Food
7.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Crew
8.6
Comfort
8.0
Overall
8.0
Food
7.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Boarding
8.1
Crew
8.6
Comfort
8.0
Overall
8.0
Food
7.0
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
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Des Moines and Florida Keys flights
Browse other Des Moines and Florida Keys flight options. Last updated on February 9, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from Des Moines to Florida Keys
Discover the top 4 airlines that operate flights from Des Moines to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$76 | Average$174 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$268 | Average$529 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$268 | Average$468 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$281 | Average$458 | FlexibilityNo cancel fee | On-time69% |