Florida Keys

$95+ Cheap flights from Des Moines (DSM) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Mar 11 — Mar 181
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Florida Keys with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to Florida Keys

Cheapest flights from Des Moines to Florida Keys
Explore the most affordable flight options available from Des Moines to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 9, 2026.

This Frontier deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:17 pm
DSM
-
MIA
1 stop8h 57m
Frontier
Thu 3/56:45 am
MIA
-
DSM
1 stop12h 57m
Frontier
Deal found 2/6$183
This Expedia deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/227:45 pm
DSM
-
MIA
1 stop8h 29m
Frontier
Thu 2/266:45 am
MIA
-
DSM
1 stop12h 57m
Frontier
Deal found 2/8$190
This Southwest deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:30 am
DSM
-
MIA
1 stop5h 25m
Southwest
Tue 4/146:40 am
MIA
-
DSM
1 stop5h 45m
Southwest
Deal found 2/6$197
This Kiwi.com deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/78:21 pm
DSM
-
MIA
1 stop7h 28m
Frontier
Tue 3/107:04 pm
MIA
-
DSM
2 stops25h 12m
Frontier
Deal found 2/5$204
This Southwest deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:10 am
DSM
-
MIA
1 stop4h 50m
Southwest
Thu 2/267:20 pm
MIA
-
DSM
1 stop5h 15m
Southwest
Deal found 2/6$205
This Kiwi.com deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:27 pm
DSM
-
MIA
1 stop8h 47m
Frontier
Sat 3/75:50 am
MIA
-
DSM
1 stop14h 26m
Frontier
Deal found 2/6$212
This Expedia deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:17 pm
DSM
-
MIA
1 stop8h 57m
Frontier
Sat 3/75:50 am
MIA
-
DSM
1 stop14h 26m
Frontier
Deal found 2/6$225
This Kiwi.com deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:27 pm
DSM
-
MIA
1 stop8h 47m
Frontier
Wed 3/115:50 am
MIA
-
DSM
1 stop14h 26m
Frontier
Deal found 2/6$228
This Kiwi.com deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:17 pm
DSM
-
MIA
2 stops39h 23m
Multiple Airlines
Sat 3/75:50 am
MIA
-
DSM
1 stop14h 26m
Multiple Airlines
Deal found 2/6$229
This Delta deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2511:33 am
DSM
-
EYW
1 stop4h 57m
Delta
Wed 4/16:25 pm
EYW
-
DSM
1 stop5h 13m
Delta
Deal found 2/8$289
This American Airlines deal was found by Cheapflights users on 2/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1811:09 am
DSM
-
EYW
2 stops10h 27m
American Airlines
Thu 4/236:46 pm
EYW
-
DSM
1 stop6h 03m
American Airlines
Deal found 2/7$294
This American Airlines deal was found by Cheapflights users on 2/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/712:00 pm
DSM
-
EYW
2 stops9h 58m
American Airlines
Tue 4/146:45 am
EYW
-
DSM
2 stops8h 01m
American Airlines
Deal found 2/6$300

Find flight deals from Des Moines to Florida Keys

Keep the following information in mind while searching for Des Moines to Florida Keys flight deals. Data was last updated February 9, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$183
(Frontier)

One-way from

$95
(Frontier)

Popular in

March

Cheapest in

June

Average price

$470
Provider with most accurate pricing for Des Moines-Miami flight deals.
Provider most trusted by Cheapflights users for Des Moines-Miami flights.
From Des Moines to Florida Keys
One-way flight from Des Moines to Florida Keys
Highest demand for flights based on searches. 12% potential increase in price ($57 potential increase over avg. RT price).
Cheapest flight prices on average. 3% potential price decrease ($12 potential savings vs. average RT price).
Average for round-trip flights in February 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 9, 2026.
Use the filters below to find and compare flights from Des Moines to Florida Keys that are best for you.

Fly from

Des Moines

Fly to

Florida Keys

Route

Depart

Return

Price

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 4/7

5:30 am-11:55 am

1 stop5h 25m

Miami

Tue 4/14

6:40 am-11:25 am

1 stop5h 45m

$197

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 3/7

4:35 pm-11:00 pm

1 stop5h 25m

Miami

Sat 3/14

6:25 am-11:30 am

1 stop6h 05m

$277

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 4/1

5:30 am-11:40 am

1 stop5h 10m

Miami

Wed 4/8

6:40 am-11:25 am

1 stop5h 45m

$285

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 3/25

11:33 am-7:41 pm

1 stop7h 08m

Key West

Wed 4/1

6:25 pm-10:38 pm

1 stop5h 13m

$289

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 4/7

6:00 am-3:24 pm

1 stop8h 24m

Key West

Tue 4/14

6:49 pm-11:49 pm

1 stop6h 00m

$289

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 3/24

5:30 am-11:40 am

1 stop5h 10m

Miami

Tue 3/31

6:55 am-8:50 pm

2 stops14h 55m

$290

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 4/7

6:15 am-5:30 pm

2 stops10h 15m

Key West

Tue 4/14

7:33 am-1:55 pm

1 stop7h 22m

$294

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 4/18

11:09 am-10:36 pm

2 stops10h 27m

Key West

Thu 4/23

6:46 pm-11:49 pm

1 stop6h 03m

$294

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 5/5

6:00 am-4:30 pm

2 stops9h 30m

Key West

Tue 5/12

6:49 pm-11:49 pm

1 stop6h 00m

$294

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 4/25

11:09 am-10:36 pm

2 stops10h 27m

Key West

Sat 5/2

6:46 pm-11:49 pm

1 stop6h 03m

$321

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/7

Showing 1-10 of 29 results
1
2
3

Best time to book a flight from Des Moines to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Florida Keys

What is the cheapest month to book a flight from Des Moines to Florida Keys?

Currently, July is the cheapest month in which you can book a flight from Des Moines to Florida Keys (average of $82). Flying from Des Moines to Florida Keys in December is currently the most expensive (average of $371). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated February 9, 2026.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Des Moines to Florida Keys. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Boarding

8.1

Crew

8.6

Comfort

8.0

Overall

8.0

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Boarding

8.1

Crew

8.6

Comfort

8.0

Overall

8.0

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Boarding

8.1

Crew

8.6

Comfort

8.0

Overall

8.0

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Boarding

8.1

Crew

8.6

Comfort

8.0

Overall

8.0

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Boarding

8.1

Crew

8.6

Comfort

8.0

Overall

8.0

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Boarding

8.1

Crew

8.6

Comfort

8.0

Overall

8.0

Food

7.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from Des Moines to Florida Keys?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Florida Keys.

  • How long is the flight from Des Moines to Florida Keys?

    Departing from Des Moines to Florida Keys will take you 5h 25m. There are 1328 mi between Des Moines and Florida Keys. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Des Moines to Florida Keys one-way?

    One-way options have recently been found by users for as low as $99 on Southwest. Other airlines that offer cheap prices include Delta from $118 and United Airlines from $158 one-way.

  • Can I find deals for flights from Des Moines to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Des Moines to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Florida Keys.

  • Can I find deals for business class flights from Des Moines to Florida Keys?

    Yes. Cheapflights offers flight deals from Des Moines to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Florida Keys?

    Currently, July is the cheapest month in which you can book a flight from Des Moines to Florida Keys (average of $82). Flying from Des Moines to Florida Keys in December is currently the most expensive (average of $371). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Des Moines to Florida Keys

Discover the top 4 airlines that operate flights from Des Moines to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 9, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$174FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$268Average$529FlexibilityNo cancel feeOn-time71%
DeltaCheapest$268Average$468FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$281Average$458FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.