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$90+ Cheap flights from Des Moines (DSM) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/15. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Des Moines to Florida Keys

Keep the following information in mind while searching for Des Moines to Florida Keys flight deals. Data was last updated September 17, 2025.

Round-trip from

$175
(Frontier)

One-way from

$90
(Southwest)

Popular in

March

Cheapest in

June

Average price

$410
From Des Moines to Florida Keys
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One-way flight from Des Moines to Florida Keys
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Highest demand for flights based on searches. 9% potential increase in price ($47 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Des Moines to Florida Keys

Cheapest flights from Des Moines to Florida Keys
Explore the most affordable flight options available from Des Moines to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Frontier deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/302:32 pmDSM - MIA
1 stop14h 47mFrontier
Thu 11/66:00 amMIA - DSM
1 stop8h 47mFrontier
Deal found 9/16$175
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/86:15 amDSM - MIA
1 stop5h 10mSouthwest
Fri 12/123:10 pmMIA - DSM
1 stop6h 50mSouthwest
Deal found 9/14$179
This Frontier deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/92:32 pmDSM - MIA
1 stop14h 47mFrontier
Sun 11/166:00 amMIA - DSM
1 stop8h 47mFrontier
Deal found 9/15$201
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/302:32 pmDSM - MIA
1 stop14h 47mMultiple Airlines
Thu 11/611:28 amMIA - DSM
1 stop9h 45mMultiple Airlines
Deal found 9/15$216
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/227:20 amDSM - MIA
1 stop8h 16mDelta
Tue 10/287:00 amMIA - DSM
1 stop8h 35mDelta
Deal found 9/14$217
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/168:00 amDSM - MIA
1 stop9h 45mSouthwest
Tue 11/255:00 pmMIA - DSM
1 stop7h 10mSouthwest
Deal found 9/15$218
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/68:00 amDSM - MIA
1 stop11h 32mMultiple Airlines
Thu 10/96:00 amMIA - DSM
1 stop8h 52mMultiple Airlines
Deal found 9/16$227
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/298:25 amDSM - MIA
1 stop7h 37mMultiple Airlines
Thu 10/25:59 pmMIA - DSM
1 stop24h 15mMultiple Airlines
Deal found 9/15$228
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/145:47 amDSM - EYW
1 stop4h 40mDelta
Wed 10/226:17 pmEYW - DSM
1 stop5h 13mDelta
Deal found 9/15$269
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/146:00 amDSM - EYW
2 stops9h 07mAmerican Airlines
Tue 10/2111:22 amEYW - DSM
2 stops9h 49mAmerican Airlines
Deal found 9/15$279
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/32:05 pmDSM - EYW
1 stop5h 02mDelta
Tue 10/712:22 pmEYW - DSM
1 stop6h 22mDelta
Deal found 9/15$294
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/37:00 amDSM - EYW
2 stops10h 59mAmerican Airlines
Tue 10/73:20 pmEYW - DSM
1 stop8h 48mAmerican Airlines
Deal found 9/15$299

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Des Moines to Florida Keys that are best for you.

Fly from

Des Moines

Fly to

Florida Keys

Route

Depart

Return

Price

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 10/22

7:03 am-1:28 pm

1 stop5h 25m

Miami

Tue 10/28

4:35 pm-10:30 pm

1 stop6h 55m

$217

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 10/25

11:06 am-5:53 pm

1 stop5h 47m

Miami

Wed 10/29

11:50 am-7:20 pm

1 stop8h 30m

$217

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sun 11/16

8:00 am-6:45 pm

1 stop9h 45m

Miami

Tue 11/25

5:00 pm-11:10 pm

1 stop7h 10m

$218

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 11/26

5:30 am-11:30 am

1 stop5h 00m

Miami

Tue 12/2

4:55 pm-9:35 pm

1 stop5h 40m

$218

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Fri 9/26

2:25 pm-12:44 am

1 stop9h 19m

Miami

Mon 9/29

6:00 am-1:40 pm

1 stop8h 40m

$241

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Fri 10/31

12:05 pm-12:21 pm

1 stop23h 16m

Miami

Fri 11/7

11:28 am-5:08 pm

1 stop6h 40m

$260

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 12/9

6:00 am-1:00 pm

1 stop6h 00m

Key West

Wed 12/17

4:10 pm-11:29 pm

1 stop8h 19m

$269

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 12/6

2:08 pm-9:50 pm

1 stop6h 42m

Key West

Sat 12/13

4:59 pm-10:59 pm

1 stop7h 00m

$269

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 10/14

5:47 am-11:27 am

1 stop4h 40m

Key West

Wed 10/22

6:17 pm-10:30 pm

1 stop5h 13m

$269

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Wed 10/29

2:13 pm-8:06 pm

1 stop4h 53m

Key West

Mon 11/3

6:17 pm-10:30 pm

1 stop5h 13m

$269

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 27 results
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Best time to book a flight from Des Moines to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Florida Keys

What is the cheapest month to book a flight from Des Moines to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Florida Keys (average of $328). Flying from Des Moines to Florida Keys in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated September 17, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Des Moines to Florida Keys. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Crew

8.6

Overall

8.0

Food

7.0

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,242 reviews
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Crew

8.6

Overall

8.0

Food

7.0

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,961 reviews
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Crew

8.6

Overall

8.0

Food

7.0

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,926 reviews
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Crew

8.6

Overall

8.0

Food

7.0

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Crew

8.6

Overall

8.0

Food

7.0

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Allegiant Air
7.2
Good
699 reviews
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Crew

8.6

Overall

8.0

Food

7.0

Comfort

8.0

Entertainment

7.5

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Florida Keys?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Florida Keys.

  • How long is the flight from Des Moines to Florida Keys?

    Departing from Des Moines to Florida Keys will take you 5h 25m. There are 1328 mi between Des Moines and Florida Keys. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Des Moines to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Des Moines to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Florida Keys.

  • Can I find deals for business class flights from Des Moines to Florida Keys?

    Yes. Cheapflights offers flight deals from Des Moines to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Florida Keys (average of $328). Flying from Des Moines to Florida Keys in March is currently the most expensive (average of $491). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Des Moines to Florida Keys

Discover the top 4 airlines that operate flights from Des Moines to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$157FlexibilityNo cancel feeOn-time88%
DeltaCheapest$268Average$473FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$268Average$485FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$281Average$503FlexibilityNo cancel feeOn-time69%

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