$118+ Cheap flights from Des Moines (DSM) to Florida Keys
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/22. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Jun 17 — Jun 241
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Florida Keys
Keep the following information in mind while searching for Des Moines to Florida Keys flight deals. Data was last updated June 12, 2025.
Round-trip from | $192 (Southwest) |
|---|---|
One-way from | $143 (FlightHub) |
Popular in | March |
Cheapest in | June |
Average price | $306 |
Find flight deals from Des Moines to Florida Keys
Cheapest flights from Des Moines to Florida KeysExplore the most affordable flight options available from Des Moines to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.
Explore the most affordable flight options available from Des Moines to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/75:25 amDSM - MIA
1 stop6h 45mSouthwest
Tue 7/86:50 amMIA - DSM
1 stop7h 10mSouthwest
Deal found 6/10![Southwest logo]()
$192
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/206:30 amDSM - MIA
1 stop27h 19mMultiple Airlines
Thu 7/2411:10 amMIA - DSM
1 stop12h 28mMultiple Airlines
Deal found 6/10![Multiple Airlines logo]()
$201
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/86:40 pmDSM - MIA
1 stop5h 07mDelta
Tue 7/156:55 amMIA - DSM
1 stop7h 44mDelta
Deal found 6/10![Delta logo]()
$217
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/56:00 amDSM - EYW
1 stop7h 00mAmerican Airlines
Tue 9/96:17 pmEYW - DSM
1 stop5h 50mAmerican Airlines
Deal found 6/11![American Airlines logo]()
$269
This FlightHub deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/283:23 pmDSM - MIA
1 stop14h 07mFrontier
Mon 9/86:00 amMIA - DSM
1 stop14h 56mFrontier
Deal found 6/12![Frontier logo]()
$275
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/88:00 amDSM - MIA
2 stops10h 39mUnited Airlines
Tue 7/154:16 pmMIA - DSM
1 stop7h 44mUnited Airlines
Deal found 6/12![United Airlines logo]()
$301
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/293:48 pmDSM - EYW
1 stop16h 45mAllegiant Air
Sun 8/38:54 amEYW - DSM
1 stop14h 16mAllegiant Air
Deal found 6/10![Allegiant Air logo]()
$305
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/25:54 amDSM - MIA
Nonstop3h 26mAmerican Airlines
Sat 11/89:00 pmMIA - DSM
Nonstop3h 45mAmerican Airlines
Deal found 6/12![American Airlines logo]()
$320
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/125:30 amDSM - EYW
1 stop6h 38mDelta
Wed 7/167:00 amEYW - DSM
1 stop7h 39mDelta
Deal found 6/11![Delta logo]()
$364
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/11:00 pmDSM - EYW
2 stops18h 00mUnited Airlines
Mon 10/66:45 pmEYW - DSM
3 stops23h 39mUnited Airlines
Deal found 6/10![United Airlines logo]()
$409
This Mytrip deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/18:00 amDSM - EYW
2 stops29h 43mMultiple Airlines
Wed 7/910:02 amEYW - DSM
3 stops37h 36mMultiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$414
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Des Moines to Florida Keys that are best for you.
Fly from
Des Moines
Fly to
Florida Keys
Route
Depart
Return
Price
Des MoinesMiami
DSM - MIA
DSMMIA
Des Moines
Mon 7/7
5:25 am-1:10 pm
1 stop6h 45m
Miami
Tue 7/8
6:50 am-1:00 pm
1 stop7h 10m
$192
Des MoinesMiami
DSM - MIA
DSMMIA
Des Moines
Sun 7/20
6:30 am-10:49 am
1 stop27h 19m
Miami
Thu 7/24
11:10 am-10:38 pm
1 stop12h 28m
$201
Des MoinesMiami
DSM - MIA
DSMMIA
Des Moines
Tue 7/8
6:40 pm-12:47 am
1 stop5h 07m
Miami
Tue 7/15
6:55 am-1:39 pm
1 stop7h 44m
$217
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Fri 9/5
6:00 am-2:00 pm
1 stop7h 00m
Key West
Tue 9/9
6:17 pm-11:07 pm
1 stop5h 50m
$269
Des MoinesMiami
DSM - MIA
DSMMIA
Des Moines
Thu 8/28
3:23 pm-6:30 am
1 stop14h 07m
Miami
Mon 9/8
6:00 am-7:56 pm
1 stop14h 56m
$275
Des MoinesMiami
DSM - MIA
DSMMIA
Des Moines
Tue 7/8
8:00 am-7:39 pm
2 stops10h 39m
Miami
Tue 7/15
4:16 pm-11:00 pm
1 stop7h 44m
$301
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Sun 6/29
3:48 pm-9:33 am
1 stop16h 45m
Key West
Sun 8/3
8:54 am-10:10 pm
1 stop14h 16m
$305
Des MoinesMiami
DSM - MIA
DSMMIA
Des Moines
Sun 11/2
5:54 am-10:20 am
Nonstop3h 26m
Miami
Sat 11/8
9:00 pm-11:45 pm
Nonstop3h 45m
$320
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Sat 7/12
5:30 am-1:08 pm
1 stop6h 38m
Key West
Wed 7/16
7:00 am-1:39 pm
1 stop7h 39m
$364
Des MoinesKey West
DSM - EYW
DSMEYW
Des Moines
Tue 7/1
8:00 am-2:43 pm
2 stops29h 43m
Key West
Wed 7/9
10:02 am-10:38 pm
3 stops37h 36m
$414
Showing 1-10 of 14 results
Best time to book a flight from Des Moines to Florida Keys
Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Florida Keys
What is the cheapest month to book a flight from Des Moines to Florida Keys?
Currently, August is the cheapest month in which you can book a flight from Des Moines to Florida Keys (average of $328). Flying from Des Moines to Florida Keys in March is currently the most expensive (average of $493). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Rainfall in Florida Keys by month
Plan your trip to Florida Keys by taking into account the average rainfall totals by month.
In terms of precipitation, rainfall in Florida Keys ranges from 1.6 - 9.9 inches per month. September is typically the wettest month, when rainfall can reach 9.9 in. January is typically the driest time to visit Florida Keys when rainfall is around 1.6 in.
Temperature in Florida Keys by month
Plan your trip to Florida Keys by taking into account the average temperature totals by month.
If weather is an important factor for your trip to Florida Keys, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 84.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 68.0 F).
Reviews of airlines servicing Florida Keys
Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated June 12, 2025.
Read through reviews of airlines operating flights from Des Moines to Florida Keys, such as Southwest, Delta and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.2
Comfort
8.0
Food
7.1
Overall
8.0
Entertainment
7.6
Crew
8.6
Reviews
1 / 20
8.0
ExcellentJohn,May 2025
PVD - BNA
Boarding
8.2
Comfort
8.0
Food
7.1
Overall
8.0
Entertainment
7.6
Crew
8.6
Reviews
1 / 20
8.0
ExcellentJohn,May 2025
PVD - BNA
Boarding
8.2
Comfort
8.0
Food
7.1
Overall
8.0
Entertainment
7.6
Crew
8.6
Reviews
1 / 20
8.0
ExcellentJohn,May 2025
PVD - BNA
Boarding
8.2
Comfort
8.0
Food
7.1
Overall
8.0
Entertainment
7.6
Crew
8.6
Reviews
1 / 20
8.0
ExcellentJohn,May 2025
PVD - BNA
Boarding
8.2
Comfort
8.0
Food
7.1
Overall
8.0
Entertainment
7.6
Crew
8.6
Reviews
1 / 20
8.0
ExcellentJohn,May 2025
PVD - BNA
Boarding
8.2
Comfort
8.0
Food
7.1
Overall
8.0
Entertainment
7.6
Crew
8.6
Reviews
1 / 20
8.0
ExcellentJohn,May 2025
PVD - BNA
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Florida Keys
See prices for flight routes from nearby airports that may be better suited for you.
Top 4 airlines flying from Des Moines to Florida Keys
Discover the top 4 airlines that operate flights from Des Moines to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$76 | Average$241 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$268 | Average$503 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$268 | Average$417 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$292 | Average$506 | FlexibilityNo cancel fee | On-time69% |