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Florida Keys

$101+ Cheap flights from Des Moines (DSM) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/20. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Jan 22 — Jan 291
Thu 1/22
Thu 1/29
1 adult, Economy
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Cheap flight deals from Des Moines to Florida Keys

Cheapest flights from Des Moines to Florida Keys
Explore the most affordable flight options available from Des Moines to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 23, 2025.

This Delta deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:35 amDSM - MIA
1 stop5h 04mDelta
Wed 12/314:01 pmMIA - DSM
1 stop5h 44mDelta
Deal found 12/20$393
This United Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:00 amDSM - EYW
1 stop6h 14mUnited Airlines
Mon 12/291:25 pmEYW - DSM
2 stops9h 15mUnited Airlines
Deal found 12/22$434
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:45 amDSM - EYW
2 stops10h 13mAmerican Airlines
Mon 12/291:46 pmEYW - DSM
2 stops11h 00mAmerican Airlines
Deal found 12/22$439
This Southwest deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/258:20 amDSM - MIA
1 stop6h 40mSouthwest
Sat 12/277:50 pmMIA - DSM
1 stop5h 05mSouthwest
Deal found 12/21$443
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/226:00 amDSM - MIA
Nonstop3h 30mAmerican Airlines
Mon 1/128:39 pmMIA - DSM
Nonstop3h 50mAmerican Airlines
Deal found 12/22$448
This United Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:00 amDSM - EYW
1 stop6h 14mUnited Airlines
Sat 12/2712:22 pmEYW - DSM
1 stop6h 43mUnited Airlines
Deal found 12/22$449
This United Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:00 amDSM - EYW
1 stop6h 14mUnited Airlines
Fri 12/2612:22 pmEYW - DSM
1 stop6h 43mUnited Airlines
Deal found 12/22$459
This Delta deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2310:29 amDSM - EYW
2 stops9h 29mDelta
Thu 12/254:25 pmEYW - DSM
1 stop5h 20mDelta
Deal found 12/22$464
This Delta deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/2310:29 amDSM - EYW
2 stops9h 29mDelta
Fri 12/267:25 amEYW - DSM
2 stops10h 16mDelta
Deal found 12/22$469
This Southwest deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:30 amDSM - MIA
1 stop5h 00mSouthwest
Sun 12/287:20 pmMIA - DSM
1 stop5h 45mSouthwest
Deal found 12/21$477
This United Airlines deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/239:00 amDSM - MIA
1 stop9h 41mUnited Airlines
Sat 12/278:45 amMIA - DSM
2 stops10h 20mUnited Airlines
Deal found 12/20$478
This Southwest deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:15 amDSM - MIA
2 stops8h 55mSouthwest
Mon 12/297:20 pmMIA - DSM
1 stop5h 45mSouthwest
Deal found 12/21$482

Find flight deals from Des Moines to Florida Keys

Keep the following information in mind while searching for Des Moines to Florida Keys flight deals. Data was last updated December 23, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$182
(Orbitz)

One-way from

$101
(Kiwi.com)

Popular in

March

Cheapest in

June

Average price

$357
Provider with most accurate pricing for Des Moines-Miami flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Miami flights.
Search Deals
From Des Moines to Florida Keys
Search Deals
One-way flight from Des Moines to Florida Keys
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($50 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Des Moines to Florida Keys that are best for you.

Fly from

Des Moines

Fly to

Florida Keys

Route

Depart

Return

Price

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 2/28

6:10 am-5:50 pm

1 stop10h 40m

Miami

Sat 3/7

6:25 am-11:30 am

1 stop6h 05m

$213

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 2/3

12:06 pm-10:03 pm

1 stop8h 57m

Miami

Tue 2/10

12:00 pm-4:28 pm

1 stop5h 28m

$237

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 2/4

12:25 pm-10:03 pm

1 stop8h 38m

Miami

Wed 2/11

5:30 pm-10:29 pm

1 stop5h 59m

$237

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 2/11

1:16 pm-11:01 pm

1 stop8h 45m

Miami

Wed 2/18

5:05 am-10:47 am

1 stop6h 42m

$257

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Thu 1/22

2:58 pm-1:30 pm

1 stop21h 32m

Key West

Thu 1/29

12:51 pm-10:46 pm

1 stop10h 55m

$269

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Tue 1/20

11:26 am-5:11 pm

1 stop4h 45m

Key West

Wed 1/28

1:28 pm-7:34 pm

1 stop7h 06m

$279

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Thu 1/22

1:16 pm-11:56 pm

2 stops9h 40m

Key West

Thu 1/29

6:43 pm-11:08 pm

1 stop5h 25m

$294

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 1/28

6:10 am-12:00 pm

1 stop4h 50m

Miami

Thu 2/5

5:50 pm-10:15 pm

1 stop5h 25m

$307

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Wed 4/15

5:30 am-3:47 pm

2 stops9h 17m

Miami

Tue 4/21

1:20 pm-9:27 pm

2 stops9h 07m

$316

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sun 2/1

5:20 am-11:30 am

1 stop5h 10m

Miami

Sat 2/7

7:35 am-2:55 pm

1 stop8h 20m

$317

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/20

Showing 1-10 of 35 results
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Best time to book a flight from Des Moines to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Florida Keys

What is the cheapest month to book a flight from Des Moines to Florida Keys?

Currently, July is the cheapest month in which you can book a flight from Des Moines to Florida Keys (average of $80). Flying from Des Moines to Florida Keys in August is currently the most expensive (average of $324). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated December 23, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Des Moines to Florida Keys. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,253 reviews

Boarding

8.1

Entertainment

7.5

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,253 reviews
Southwest
8.0
Very good
4,253 reviews

Boarding

8.1

Entertainment

7.5

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,014 reviews
Southwest
8.0
Very good
4,253 reviews

Boarding

8.1

Entertainment

7.5

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
United Airlines
7.4
Good
9,106 reviews
Southwest
8.0
Very good
4,253 reviews

Boarding

8.1

Entertainment

7.5

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,054 reviews
Southwest
8.0
Very good
4,253 reviews

Boarding

8.1

Entertainment

7.5

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Allegiant Air
7.2
Good
701 reviews
Southwest
8.0
Very good
4,253 reviews

Boarding

8.1

Entertainment

7.5

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Florida Keys?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Florida Keys.

  • How long is the flight from Des Moines to Florida Keys?

    Departing from Des Moines to Florida Keys will take you 8h 45m. There are 1328 mi between Des Moines and Florida Keys. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Des Moines to Florida Keys one-way?

    One-way options have recently been found by users for as low as $99 on Southwest. Other airlines that offer cheap prices include Delta from $128 and American Airlines from $156 one-way.

  • Can I find deals for flights from Des Moines to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Des Moines to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Florida Keys.

  • Can I find deals for business class flights from Des Moines to Florida Keys?

    Yes. Cheapflights offers flight deals from Des Moines to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Florida Keys?

    Currently, July is the cheapest month in which you can book a flight from Des Moines to Florida Keys (average of $80). Flying from Des Moines to Florida Keys in August is currently the most expensive (average of $324). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Florida Keys

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Des Moines to Florida Keys

Discover the top 4 airlines that operate flights from Des Moines to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$174FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$268Average$534FlexibilityNo cancel feeOn-time71%
DeltaCheapest$268Average$498FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$281Average$498FlexibilityNo cancel feeOn-time69%

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