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Florida Keys

$89+ Cheap flights from Des Moines (DSM) to Florida Keys

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/7. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — EYW
Aug 5 — Aug 121
Tue 8/5
Tue 8/12
1 adult, Economy
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Cheap flight deals from Des Moines to Florida Keys

Keep the following information in mind while searching for Des Moines to Florida Keys flight deals. Data was last updated July 31, 2025.

Round-trip from

$174
(American Airlines)

One-way from

$89
(Southwest)

Popular in

March

Cheapest in

June

Average price

$462
From Des Moines to Florida Keys
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One-way flight from Des Moines to Florida Keys
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Highest demand for flights based on searches. 9% potential increase in price ($43 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Des Moines to Florida Keys

Cheapest flights from Des Moines to Florida Keys
Explore the most affordable flight options available from Des Moines to Florida Keys. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.

This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/236:45 amDSM - MIA
Nonstop3h 30mAmerican Airlines
Sat 8/307:51 pmMIA - DSM
Nonstop3h 39mAmerican Airlines
Deal found 7/30$174
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/168:25 amDSM - MIA
1 stop4h 40mSouthwest
Wed 9/172:50 pmMIA - DSM
1 stop8h 30mSouthwest
Deal found 7/30$184
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1310:20 amDSM - MIA
1 stop7h 31mDelta
Sat 9/206:00 amMIA - DSM
1 stop5h 40mDelta
Deal found 7/30$217
This Mytrip deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:00 amDSM - MIA
1 stop11h 35mMultiple Airlines
Thu 10/237:00 amMIA - DSM
2 stops13h 57mMultiple Airlines
Deal found 7/29$251
This Frontier deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/296:20 pmDSM - MIA
1 stop11h 10mFrontier
Mon 9/16:00 amMIA - DSM
1 stop9h 23mFrontier
Deal found 7/30$258
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/56:00 amDSM - EYW
1 stop7h 00mAmerican Airlines
Tue 9/912:00 pmEYW - DSM
1 stop5h 49mAmerican Airlines
Deal found 7/30$269
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/112:58 pmDSM - MIA
1 stop6h 54mUnited Airlines
Sat 10/186:05 amMIA - DSM
2 stops9h 18mUnited Airlines
Deal found 7/29$281
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/32:05 pmDSM - EYW
1 stop5h 02mDelta
Mon 10/66:17 pmEYW - DSM
1 stop5h 26mDelta
Deal found 7/30$294
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/198:00 amDSM - EYW
1 stop6h 06mUnited Airlines
Tue 12/234:05 pmEYW - DSM
1 stop6h 35mUnited Airlines
Deal found 7/31$472
This Mytrip deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/282:39 pmDSM - EYW
3 stops25h 12mMultiple Airlines
Thu 9/412:29 pmEYW - DSM
2 stops21h 25mMultiple Airlines
Deal found 7/29$494

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Florida Keys that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Des Moines to Florida Keys that are best for you.

Fly from

Des Moines

Fly to

Florida Keys

Route

Depart

Return

Price

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 8/23

6:45 am-11:15 am

Nonstop3h 30m

Miami

Sat 8/30

7:51 pm-10:30 pm

Nonstop3h 39m

$174

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Tue 9/16

8:25 am-2:05 pm

1 stop4h 40m

Miami

Wed 9/17

2:50 pm-10:20 pm

1 stop8h 30m

$184

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 9/13

5:12 pm-12:23 am

1 stop6h 11m

Miami

Sat 9/20

6:00 am-10:40 am

1 stop5h 40m

$217

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Fri 10/17

8:00 am-8:35 pm

1 stop11h 35m

Miami

Thu 10/23

7:00 am-7:57 pm

2 stops13h 57m

$251

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Fri 8/29

6:20 pm-6:30 am

1 stop11h 10m

Miami

Mon 9/1

6:00 am-2:23 pm

1 stop9h 23m

$258

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 9/5

6:00 am-2:00 pm

1 stop7h 00m

Key West

Tue 9/9

12:00 pm-4:49 pm

1 stop5h 49m

$269

Des MoinesMiami

DSM - MIA

DSMMIA

Des Moines

Sat 10/11

2:58 pm-10:52 pm

1 stop6h 54m

Miami

Sat 10/18

6:05 am-2:23 pm

2 stops9h 18m

$281

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Fri 10/3

2:05 pm-8:07 pm

1 stop5h 02m

Key West

Mon 10/6

6:17 pm-10:43 pm

1 stop5h 26m

$294

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Thu 8/28

2:39 pm-4:51 pm

3 stops25h 12m

Key West

Thu 9/4

12:29 pm-8:54 am

2 stops21h 25m

$494

Des MoinesKey West

DSM - EYW

DSMEYW

Des Moines

Sat 9/27

8:00 am-2:29 pm

3 stops29h 29m

Key West

Tue 9/30

3:12 pm-10:42 am

2 stops20h 30m

$651

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Showing 1-10 of 20 results
1
2

Best time to book a flight from Des Moines to Florida Keys

Have a flexible travel schedule? Discover the best time to fly to Florida Keys from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Florida Keys

What is the cheapest month to book a flight from Des Moines to Florida Keys?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Florida Keys (average of $328). Flying from Des Moines to Florida Keys in March is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florida Keys

Get insights into the airlines that provide service to Florida Keys. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florida Keys. Reviews last updated July 31, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Des Moines to Florida Keys. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,246 reviews

Food

7.0

Overall

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Southwest
8.0
Very good
4,246 reviews
Southwest
8.0
Very good
4,246 reviews

Food

7.0

Overall

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Delta
8.0
Very good
7,981 reviews
Southwest
8.0
Very good
4,246 reviews

Food

7.0

Overall

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
United Airlines
7.4
Good
8,900 reviews
Southwest
8.0
Very good
4,246 reviews

Food

7.0

Overall

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,246 reviews

Food

7.0

Overall

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Frontier
5.9
Fair
3,239 reviews
Southwest
8.0
Very good
4,246 reviews

Food

7.0

Overall

8.0

Crew

8.6

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Florida Keys. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Florida Keys?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly out of when you book flights from Des Moines to Florida Keys.

  • What are the cheapest airlines to fly from Des Moines to Florida Keys one-way?

    One-way options have recently been found by users for as low as $89 on Southwest. Other airlines that offer cheap prices include Frontier from $127 and Delta from $129 one-way.

  • Can I find deals for flights from Des Moines to Florida Keys that include hotel bookings?

    Yes. In addition to deals on Des Moines to Florida Keys flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Florida Keys?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Florida Keys.

  • Can I find deals for business class flights from Des Moines to Florida Keys?

    Yes. Cheapflights offers flight deals from Des Moines to Florida Keys by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Florida Keys?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Florida Keys (average of $328). Flying from Des Moines to Florida Keys in March is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Des Moines to Florida Keys

Discover the top 4 airlines that operate flights from Des Moines to Florida Keys. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$157FlexibilityNo cancel feeOn-time88%
DeltaCheapest$268Average$496FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$268Average$430FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$292Average$505FlexibilityNo cancel feeOn-time69%

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