HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$418+ Cheap flights from Maine to Florence, SC (FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/1. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — FLO
Aug 26 — Sep 21
Wed 8/26
Wed 9/2
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Maine to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Maine to Florence

Cheapest flights from Maine to Florence
Explore the most affordable flight options available from Maine to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 27, 2026.

This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:36 pm
BOS
-
FLO
1 stop5h 27m
American Airlines
Wed 12/95:15 am
FLO
-
BOS
1 stop4h 42m
American Airlines
Deal found 7/22$483
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/73:38 pm
BOS
-
FLO
1 stop7h 21m
American Airlines
Sat 9/121:43 pm
FLO
-
BOS
1 stop6h 33m
American Airlines
Deal found 7/22$517
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/15:23 pm
BOS
-
FLO
1 stop6h 14m
American Airlines
Sat 8/86:22 am
FLO
-
BOS
1 stop4h 13m
American Airlines
Deal found 7/24$539
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/151:03 pm
BOS
-
FLO
2 stops10h 53m
American Airlines
Sat 11/212:35 pm
FLO
-
BOS
1 stop5h 19m
American Airlines
Deal found 7/22$570
This American Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:45 pm
BOS
-
FLO
1 stop5h 14m
American Airlines
Thu 9/101:43 pm
FLO
-
BOS
1 stop6h 33m
American Airlines
Deal found 7/26$571

Find flight deals from Maine to Florence

Keep the following information in mind while searching for Maine to Florence flight deals. Data was last updated July 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$483
(American Airlines)

One-way from

$418
(American Airlines)
Provider with most accurate pricing for Portland-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Portland-Florence flights.
Search Deals
From Maine to Florence
Search Deals
One-way flight from Maine to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Maine to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 27, 2026.
Use the filters below to find and compare flights from Maine to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Mon 9/7

3:38 pm-10:59 pm

1 stop7h 21m

Florence

Sat 9/12

1:43 pm-8:16 pm

1 stop6h 33m

$517

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Tue 8/4

4:46 pm-11:37 pm

1 stop6h 51m

Florence

Tue 8/11

6:22 am-12:38 pm

1 stop6h 16m

$539
Quickest round-trip

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Thu 9/3

5:45 pm-10:59 pm

1 stop5h 14m

Florence

Thu 9/10

1:43 pm-8:16 pm

1 stop6h 33m

$571
Cheapest one-way

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Sat 8/1

5:23 pm-11:37 pm

1 stop6h 14m

$418

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Fri 8/21

9:16 am-2:56 pm

1 stop5h 40m

$443

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Thu 9/3

9:16 am-2:56 pm

1 stop5h 40m

$448
Quickest one-way

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Thu 10/1

5:56 pm-10:58 pm

1 stop5h 02m

$448

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Mon 9/7

3:38 pm-10:59 pm

1 stop7h 21m

$448

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Thu 8/20

10:28 am-10:59 pm

2 stops12h 31m

$467

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/23

Sorted by cheapest first

Best time to book a flight from Maine to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Maine with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Maine to Florence

No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Maine to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Maine?

    Most people fly into Florence (FLO) if they book a flight to Florence from Maine. Florence is conveniently located just 2.3 mi from Florence’s city center.

  • How long is the flight from Maine to Florence, South Carolina?

    Airlines like American Airlines fly from Maine to Florence, South Carolina in about 7h 21m. The time it takes to get you to your destination can typically vary by up to . The distance from Maine to Florence, South Carolina is about 735 mi.

  • Can I find deals for flights from Maine to Florence that include hotel bookings?

    Yes. In addition to deals on Maine to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Maine to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Maine to Florence.

  • Can I find deals for business class flights from Maine to Florence?

    Yes. Cheapflights offers flight deals from Maine to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Maine to Florence

See prices for flight routes from nearby airports that may be better suited for you.
Newark to Charlotte flights
John F Kennedy Intl to Charlotte flights
LaGuardia to Charlotte flights
LaGuardia to Charleston flights
Newark to Myrtle Beach flights
Newark to Charleston flights
Boston to Charlotte flights
O'Hare Intl to Charlotte flights
Boston to Charleston flights
LaGuardia to Myrtle Beach flights
John F Kennedy Intl to Myrtle Beach flights
John F Kennedy Intl to Charleston flights
Dallas/Fort Worth to Charlotte flights
Baltimore to Charlotte flights
Detroit to Charlotte flights
John F Kennedy Intl to Savannah flights
Hobby to Charlotte flights
Dulles Intl to Charleston flights
Newark to Savannah flights
Boston to Savannah flights
Dulles Intl to Charlotte flights
Stewart to Myrtle Beach flights
O'Hare Intl to Charleston flights
LaGuardia to Savannah flights
Philadelphia to Charlotte flights
Minneapolis to Charlotte flights
Denver to Charlotte flights
Hartford to Myrtle Beach flights
George Bush Intcntl to Charlotte flights
Reagan-National to Charleston flights
Reagan-National to Charlotte flights
O'Hare Intl to Myrtle Beach flights
Newark to Greenville flights
Philadelphia to Charleston flights
O'Hare Intl to Savannah flights
Los Angeles to Charlotte flights
Philadelphia to Myrtle Beach flights
Dallas/Fort Worth to Charleston flights
LaGuardia to Greenville flights
Baltimore to Charleston flights
Seattle to Charlotte flights
Detroit to Myrtle Beach flights
Minneapolis to Savannah flights
Newark to Columbia flights
White Plains to Myrtle Beach flights
Denver to Charleston flights
Akron to Myrtle Beach flights
Fort Lauderdale to Charlotte flights
Dulles Intl to Myrtle Beach flights
Sky Harbor Intl to Charlotte flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.