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Florence

$319+ Cheap flights from Maine to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — FLO
May 30 — Jun 61
Sat 5/30
Sat 6/6
1 adult, Economy
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Cheap flight deals from Maine to Florence

Cheapest flights from Maine to Florence
Explore the most affordable flight options available from Maine to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2026.

This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:00 am
BOS
-
FLO
1 stop7h 10m
American Airlines
Wed 6/32:35 pm
FLO
-
BOS
1 stop5h 33m
American Airlines
Deal found 4/27$319
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:36 pm
BOS
-
FLO
1 stop5h 23m
American Airlines
Thu 9/105:31 am
FLO
-
BOS
1 stop3h 47m
American Airlines
Deal found 4/25$339
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/14:46 pm
BOS
-
FLO
1 stop5h 14m
American Airlines
Mon 6/85:05 am
FLO
-
BOS
1 stop6h 06m
American Airlines
Deal found 4/30$359
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/82:25 pm
BOS
-
FLO
1 stop5h 42m
American Airlines
Wed 7/155:17 am
FLO
-
BOS
1 stop5h 52m
American Airlines
Deal found 4/27$399
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:00 am
BOS
-
FLO
2 stops8h 10m
American Airlines
Sat 7/182:35 pm
FLO
-
BOS
1 stop6h 25m
American Airlines
Deal found 4/27$404
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/283:39 pm
PWM
-
FLO
2 stops7h 03m
American Airlines
Mon 5/45:20 am
FLO
-
PWM
1 stop5h 55m
American Airlines
Deal found 4/27$619

Find flight deals from Maine to Florence

Keep the following information in mind while searching for Maine to Florence flight deals. Data was last updated April 30, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$319
(American Airlines)
Provider with most accurate pricing for Portland-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Portland-Florence flights.
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From Maine to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Maine to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2026.
Use the filters below to find and compare flights from Maine to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Wed 5/27

7:00 am-2:10 pm

1 stop7h 10m

Florence

Wed 6/3

2:35 pm-8:08 pm

1 stop5h 33m

$319

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Sat 6/6

6:26 am-2:10 pm

2 stops7h 44m

Florence

Sat 6/13

2:35 pm-8:59 pm

1 stop6h 24m

$324
Quickest round-trip

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Wed 5/13

10:51 am-3:50 pm

1 stop4h 59m

Florence

Sun 5/17

5:20 am-10:01 am

1 stop4h 41m

$429

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Sun 7/5

8:05 am-2:10 pm

1 stop6h 05m

Florence

Sat 7/18

2:35 pm-9:00 pm

1 stop6h 25m

$489

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Sat 7/11

6:00 am-2:10 pm

2 stops8h 10m

Florence

Fri 7/17

5:17 am-9:20 am

1 stop4h 03m

$519

BostonFlorence

BOS - FLO

BOSFLO

Boston Logan Intl

Thu 7/9

8:03 am-2:10 pm

2 stops6h 07m

Florence

Sat 7/18

2:35 pm-11:51 pm

2 stops9h 16m

$529

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/27

Sorted by cheapest first

Best time to book a flight from Maine to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Maine with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Maine to Florence
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Maine to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Maine?

    Most people fly into Florence (FLO) if they book a flight to Florence from Maine. Florence is conveniently located just 2.3 mi from Florence’s city center.

  • How long is the flight from Maine to Florence, South Carolina?

    Airlines like American Airlines fly from Maine to Florence, South Carolina in about 7h 10m. The time it takes to get you to your destination can typically vary by up to . The distance from Maine to Florence, South Carolina is about 735 mi.

  • Can I find deals for flights from Maine to Florence that include hotel bookings?

    Yes. In addition to deals on Maine to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Maine to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Maine to Florence.

  • Can I find deals for business class flights from Maine to Florence?

    Yes. Cheapflights offers flight deals from Maine to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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