$654+ Cheap flights from Maine to Florence, SC (FLO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/26. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — FLO
Oct 26 — Nov 21
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Maine to FlorenceExplore the most affordable flight options available from Maine to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 26, 2026.
Explore the most affordable flight options available from Maine to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 26, 2026.
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:00 am -
1 stop6h 18m
Mon 9/286:24 am -
1 stop6h 18m
Deal found 9/22![American Airlines logo]()
$654
This American Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/114:29 pm -
1 stop7h 28m
Thu 10/152:34 pm -
1 stop4h 10m
Deal found 9/26![American Airlines logo]()
$915
Best flights from Maine to FlorenceDiscover carefully curated flight deals from Maine to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 26, 2026.
Discover carefully curated flight deals from Maine to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 26, 2026.
This American Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/114:29 pm -
1 stop7h 28m
Thu 10/152:34 pm -
1 stop4h 10m
Deal found 9/26![American Airlines logo]()
$915
Last-minute flights from Maine to FlorenceDiscover last-minute flight deals from Maine to Florence. Data last updated September 26, 2026 and is based on user searches.
Discover last-minute flight deals from Maine to Florence. Data last updated September 26, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:00 am -
1 stop6h 18m
Mon 9/286:24 am -
1 stop6h 18m
Deal found 9/22![American Airlines logo]()
$654
This American Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/114:29 pm -
1 stop7h 28m
Thu 10/152:34 pm -
1 stop4h 10m
Deal found 9/26![American Airlines logo]()
$915
Find flight deals from Maine to Florence
Keep the following information in mind while searching for Maine to Florence flight deals. Data was last updated September 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $915 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Maine to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 26, 2026.
Use the filters below to find and compare flights from Maine to Florence that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
PortlandFlorence
PWM Portland - FLO Florence
PWMFLO
Portland
Sun 10/11
4:29 pm-11:57 pm
1 stop7h 28m
Florence
Thu 10/15
2:34 pm-6:44 pm
1 stop4h 10m
$915
Sorted by cheapest first
Best time to book a flight from Maine to Florence
Have a flexible travel schedule? Discover the best time to fly to Florence from Maine with our price prediction graph.
PWM-FLO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Maine to Florence
USME-FLO
PWM-FLO
No data available for this route at this time. Please check back soon.
Related info for your journey
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