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$534+ Cheap flights from Portland, ME to Florence, SC (PWM - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/11. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — FLO
Jul 8 — Jul 151
Tue 7/8
Tue 7/15
1 adult, Economy
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Find flight deals from Portland to Florence

Cheapest flights from Portland to Florence
Explore the most affordable flight options available from Portland to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 3, 2025.

This American Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/116:01 pmPWM - FLO
1 stop5h 58mAmerican Airlines
Sun 7/135:07 amFLO - PWM
2 stops11h 36mAmerican Airlines
Deal found 7/2$534

Best time to book a flight from Portland to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Portland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Portland to Florence

What is the cheapest month to book a flight from Portland, Maine to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Portland, Maine to Florence, South Carolina (average of $366). Flying from Portland, Maine to Florence, South Carolina in October is currently the most expensive (average of $487). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Portland to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • Can I find deals for flights from Portland to Florence that include hotel bookings?

    Yes. In addition to deals on Portland to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Portland to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Portland to Florence.

  • Can I find deals for business class flights from Portland to Florence?

    Yes. Cheapflights offers flight deals from Portland to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Portland, Maine to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Portland, Maine to Florence, South Carolina (average of $366). Flying from Portland, Maine to Florence, South Carolina in October is currently the most expensive (average of $487). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Portland?

Book flights to Portland if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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