$79+ Cheap flights from Portland, ME (PWM) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/22. Fares are subject to change and may not be available on all flights or dates of travel.
PWM — CHS
Dec 13 — Dec 201
Round-trip
1 adult, Economy
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Find cheap flights from Portland to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Portland to South CarolinaExplore the most affordable flight options available from Portland to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2026.
Explore the most affordable flight options available from Portland to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2026.
This Super.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/75:35 pm -
Nonstop2h 43m
Fri 12/112:30 pm -
Nonstop2h 25m
Deal found 11/10![Breeze Airways logo]()
$143
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:35 pm -
Nonstop2h 43m
Mon 12/142:30 pm -
Nonstop2h 25m
Deal found 11/11![Breeze Airways logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:35 pm -
Nonstop2h 43m
Mon 12/148:58 pm -
3 stops36h 10m
Deal found 11/11![Multiple Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/145:35 pm -
Nonstop2h 43m
Fri 12/182:30 pm -
Nonstop2h 25m
Deal found 11/12![Breeze Airways logo]()
$308
This Breeze Airways deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/45:35 pm -
Nonstop2h 43m
Mon 12/72:30 pm -
Nonstop2h 25m
Deal found 11/10![Breeze Airways logo]()
$328
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/35:36 am -
1 stop6h 40m
Sun 12/66:40 pm -
1 stop4h 51m
Deal found 11/10![American Airlines logo]()
$349
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/46:00 am -
2 stops11h 14m
Sun 12/66:02 pm -
1 stop5h 50m
Deal found 11/10![Delta logo]()
$354
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:00 am -
1 stop4h 49m
Wed 12/166:28 pm -
1 stop4h 56m
Deal found 11/11![United Airlines logo]()
$357
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:00 am -
1 stop7h 33m
Wed 12/166:00 am -
2 stops9h 20m
Deal found 11/11![Delta logo]()
$362
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:18 pm -
1 stop4h 25m
Wed 12/25:00 pm -
1 stop6h 20m
Deal found 11/9![Delta logo]()
$394
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/164:02 pm -
1 stop4h 48m
Sat 12/196:02 pm -
1 stop4h 57m
Deal found 11/9![American Airlines logo]()
$394
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:50 am -
2 stops8h 27m
Wed 12/210:00 am -
2 stops9h 25m
Deal found 11/9![United Airlines logo]()
$404
Best flights from Portland to South CarolinaDiscover carefully curated flight deals from Portland to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 13, 2026.
Discover carefully curated flight deals from Portland to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 13, 2026.
This Breeze Airways deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/115:00 pm -
Nonstop2h 43m
Fri 1/221:55 pm -
Nonstop2h 25m
Deal found 11/9![Breeze Airways logo]()
$128
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/216:00 am -
1 stop8h 10m
Tue 4/275:00 pm -
1 stop6h 06m
Deal found 11/9![Delta logo]()
$349
This Breeze Airways deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/225:00 pm -
Nonstop2h 43m
Mon 1/259:32 pm -
1 stop11h 49m
Deal found 11/8![Breeze Airways logo]()
$176
This Southwest deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/285:20 am -
1 stop10h 15m
Sat 5/111:25 am -
1 stop4h 45m
Deal found 11/10![Southwest logo]()
$414
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/277:00 am -
1 stop5h 00m
Sat 1/305:06 pm -
1 stop4h 28m
Deal found 11/10![American Airlines logo]()
$417
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/69:10 am -
2 stops11h 53m
Wed 2/106:30 am -
2 stops8h 03m
Deal found 11/11![United Airlines logo]()
$468
This Breeze Airways deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/195:00 pm -
Nonstop2h 43m
Mon 3/221:55 pm -
Nonstop2h 25m
Deal found 11/10![Breeze Airways logo]()
$233
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/46:00 am -
1 stop5h 08m
Sun 12/66:02 pm -
1 stop5h 50m
Deal found 11/10![Delta logo]()
$349
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/97:00 am -
1 stop4h 53m
Tue 3/233:34 pm -
1 stop6h 28m
Deal found 11/9![American Airlines logo]()
$417
This Southwest deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/2212:55 pm -
1 stop4h 30m
Mon 1/2510:45 am -
2 stops11h 05m
Deal found 11/12![Southwest logo]()
$417
This Breeze Airways deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/85:00 pm -
Nonstop2h 43m
Mon 3/159:32 pm -
1 stop11h 49m
Deal found 11/12![Breeze Airways logo]()
$350
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:12 am -
2 stops7h 02m
Sun 12/66:02 pm -
1 stop5h 50m
Deal found 11/10![Delta logo]()
$399
This Southwest deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/225:30 am -
2 stops12h 10m
Mon 1/256:40 am -
2 stops8h 10m
Deal found 11/8![Southwest logo]()
$422
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/85:30 am -
1 stop5h 36m
Mon 1/1111:48 am -
1 stop4h 46m
Deal found 11/10![Delta logo]()
$412
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/145:20 am -
1 stop7h 20m
Wed 4/211:25 pm -
1 stop3h 50m
Deal found 11/9![Southwest logo]()
$429
This Delta deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:00 am -
1 stop7h 33m
Sun 12/66:57 pm -
1 stop4h 55m
Deal found 11/8![Delta logo]()
$422
This United Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/46:00 am -
2 stops8h 22m
Sun 2/76:30 am -
2 stops12h 51m
Deal found 11/12![United Airlines logo]()
$567
This Southwest deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/225:30 am -
2 stops7h 20m
Sun 1/248:00 am -
1 stop6h 50m
Deal found 11/12![Southwest logo]()
$447
This Delta deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/196:30 am -
1 stop5h 40m
Wed 4/214:30 pm -
1 stop6h 53m
Deal found 11/12![Delta logo]()
$426
This United Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/17:16 pm -
1 stop4h 26m
Wed 5/57:35 pm -
1 stop4h 09m
Deal found 11/10![United Airlines logo]()
$578
This Southwest deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/268:40 am -
2 stops11h 50m
Sun 2/287:45 pm -
1 stop4h 05m
Deal found 11/12![Southwest logo]()
$447
This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/265:45 am -
1 stop4h 51m
Mon 11/305:47 pm -
1 stop5h 05m
Deal found 11/11![American Airlines logo]()
$622
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/82:35 pm -
2 stops9h 00m
Fri 3/1911:10 am -
1 stop5h 03m
Deal found 11/11![Delta logo]()
$427
This United Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/59:38 am -
1 stop4h 46m
Wed 12/93:03 pm -
1 stop4h 09m
Deal found 11/10![United Airlines logo]()
$579
This Southwest deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/611:10 am -
2 stops9h 00m
Tue 12/87:05 am -
2 stops14h 45m
Deal found 11/10![Southwest logo]()
$448
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:00 am -
2 stops10h 53m
Sat 12/197:37 pm -
1 stop4h 22m
Deal found 11/11![United Airlines logo]()
$584
This Delta deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/136:00 am -
1 stop7h 35m
Fri 3/196:00 am -
2 stops10h 13m
Deal found 11/12![Delta logo]()
$449
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/247:54 am -
1 stop7h 08m
Sun 2/287:10 pm -
2 stops17h 17m
Deal found 11/8![American Airlines logo]()
$696
This Southwest deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:20 am -
2 stops13h 10m
Sun 12/134:30 pm -
2 stops17h 20m
Deal found 11/10![Southwest logo]()
$480
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/196:00 am -
1 stop5h 26m
Mon 3/225:25 pm -
1 stop6h 24m
Deal found 11/10![Delta logo]()
$449
Last-minute flights from Portland to South CarolinaDiscover last-minute flight deals from Portland to South Carolina. Data last updated November 13, 2026 and is based on user searches.
Discover last-minute flight deals from Portland to South Carolina. Data last updated November 13, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:18 pm -
1 stop4h 25m
Wed 12/25:00 pm -
1 stop6h 20m
Deal found 11/9![Delta logo]()
$394
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:50 am -
2 stops8h 27m
Wed 12/210:00 am -
2 stops9h 25m
Deal found 11/9![United Airlines logo]()
$404
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/35:36 am -
1 stop6h 40m
Sun 12/66:40 pm -
1 stop4h 51m
Deal found 11/10![American Airlines logo]()
$349
This Breeze Airways deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/45:35 pm -
Nonstop2h 43m
Mon 12/72:30 pm -
Nonstop2h 25m
Deal found 11/10![Breeze Airways logo]()
$328
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/46:00 am -
2 stops11h 14m
Sun 12/66:02 pm -
1 stop5h 50m
Deal found 11/10![Delta logo]()
$354
This Super.com deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/75:35 pm -
Nonstop2h 43m
Fri 12/112:30 pm -
Nonstop2h 25m
Deal found 11/10![Breeze Airways logo]()
$143
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:00 am -
1 stop4h 49m
Wed 12/166:28 pm -
1 stop4h 56m
Deal found 11/11![United Airlines logo]()
$357
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:00 am -
1 stop7h 33m
Wed 12/166:00 am -
2 stops9h 20m
Deal found 11/11![Delta logo]()
$362
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:35 pm -
Nonstop2h 43m
Mon 12/142:30 pm -
Nonstop2h 25m
Deal found 11/11![Breeze Airways logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/115:35 pm -
Nonstop2h 43m
Mon 12/148:58 pm -
3 stops36h 10m
Deal found 11/11![Multiple Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/145:35 pm -
Nonstop2h 43m
Fri 12/182:30 pm -
Nonstop2h 25m
Deal found 11/12![Breeze Airways logo]()
$308
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/164:02 pm -
1 stop4h 48m
Sat 12/196:02 pm -
1 stop4h 57m
Deal found 11/9![American Airlines logo]()
$394
One-way flights from Portland to South CarolinaSearch for one-way flight options from Portland to South Carolina. Find affordable one-way fares based on user searches. Data last updated November 13, 2026.
Search for one-way flight options from Portland to South Carolina. Find affordable one-way fares based on user searches. Data last updated November 13, 2026.
This Breeze Airways deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/225:00 pm -
Nonstop2h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/10![Breeze Airways logo]()
$79
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/1310:31 am -
1 stop21h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Breeze Airways logo]()
$170
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/154:02 pm -
1 stop6h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![American Airlines logo]()
$173
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/96:00 am -
1 stop4h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![United Airlines logo]()
$174
This Kiwi.com deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/96:31 pm -
1 stop17h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/12![Breeze Airways logo]()
$176
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/156:00 am -
2 stops9h 32m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![United Airlines logo]()
$178
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/2311:01 am -
1 stop4h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/12![American Airlines logo]()
$179
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/84:53 pm -
1 stop4h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/10![Delta logo]()
$179
This Southwest deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/95:05 am -
2 stops12h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/12![Southwest logo]()
$184
This Kiwi.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1712:28 pm -
2 stops27h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/8![Multiple Airlines logo]()
$188
This Breeze Airways deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/119:48 am -
1 stop5h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/10![Breeze Airways logo]()
$190
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1712:49 pm -
1 stop5h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/11![Delta logo]()
$198
Find flight deals from Portland to South Carolina
Keep the following information in mind while searching for Portland to South Carolina flight deals. Data was last updated November 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $128 (Kiwi.com) |
One-way from | $79 (Breeze Airways) |
Popular in | December |
Cheapest in | January |
Average price | $436 |
Good round-trip deal | $232 or less |
Good one-way deal | $105 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Portland to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 13, 2026.
Use the filters below to find and compare flights from Portland to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
PortlandCharleston
PWM Portland - CHS Charleston
PWMCHS
Portland
Mon 1/11
5:00 pm-7:43 pm
Nonstop2h 43m
Charleston
Fri 1/22
1:55 pm-4:20 pm
Nonstop2h 25m
$128
PortlandCharleston
PWM Portland - CHS Charleston
PWMCHS
Portland
Sun 12/13
10:31 am-7:39 am
1 stop21h 08m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$170
PortlandCharleston
PWM Portland - CHS Charleston
PWMCHS
Portland
Wed 3/17
11:25 am-5:15 pm
1 stop5h 50m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$173
PortlandMyrtle Beach
PWM Portland - MYR Myrtle Beach Intl
PWMMYR
Portland
Sat 1/9
6:00 am-10:46 am
1 stop4h 46m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$174
PortlandCharleston
PWM Portland - CHS Charleston
PWMCHS
Portland
Fri 1/22
5:00 pm-7:43 pm
Nonstop2h 43m
Charleston
Mon 1/25
9:32 pm-9:21 am
1 stop11h 49m
$176
PortlandCharleston
PWM Portland - CHS Charleston
PWMCHS
Portland
Tue 12/15
6:00 am-3:32 pm
2 stops9h 32m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$178
PortlandCharleston
PWM Portland - CHS Charleston
PWMCHS
Portland
Wed 12/16
7:00 am-3:32 pm
2 stops8h 32m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$178
PortlandMyrtle Beach
PWM Portland - MYR Myrtle Beach Intl
PWMMYR
Portland
Tue 2/23
11:01 am-3:35 pm
1 stop4h 34m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$179
PortlandGreenville
PWM Portland - GSP Greenville
PWMGSP
Portland
Tue 12/8
4:53 pm-9:49 pm
1 stop4h 56m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$179
PortlandMyrtle Beach
PWM Portland - MYR Myrtle Beach Intl
PWMMYR
Portland
Sat 1/9
5:05 am-5:50 pm
2 stops12h 45m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$184
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Portland to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Portland with our price prediction graph.
PWM-CHS
PWM-MYR
PWM-GSP
PWM-HHH
PWM-CAE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Portland to South Carolina
PWM-USSC
PWM-CHS
PWM-MYR
PWM-GSP
PWM-HHH
What is the cheapest month to book a flight from Portland, Maine to South Carolina?
Currently, January is the cheapest month in which you can book a flight from Portland, Maine to South Carolina (average of $266). Flying from Portland, Maine to South Carolina in April is currently the most expensive (average of $489). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PWM to SC?
Find hourly flight availability from Portland to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 13, 2026.
One of the essential ways to save on airfare from Portland, Maine to South Carolina is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the evening could potentially save you up to 44% on airfare.
How much does it cost to fly round-trip from Portland, Maine to South Carolina?
Airfare is below average for this route at the moment.
Portland, Maine to South Carolina flights typically cost between $278 and $513 in January.The cheapest round-trip price found within the last 5 days was $128 on Breeze Airways (Jan 22-Jan 25).
How far ahead should I book a flight from Portland, Maine to South Carolina?
The price you pay for your flight from Portland, Maine to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 71 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated November 13, 2026.
Read reviews from past customers who have flown Breeze Airways,Southwest, andDelta from Portland to South Carolina. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.2
Crew
8.8
Boarding
8.4
Comfort
8.2
Food
6.7
Entertainment
6.8
Reviews
1 / 17
10.0
ExcellentJames,Oct 2026
RSW - RDU
Overall
8.2
Crew
8.8
Boarding
8.4
Comfort
8.2
Food
6.7
Entertainment
6.8
Reviews
1 / 17
10.0
ExcellentJames,Oct 2026
RSW - RDU
Overall
8.2
Crew
8.8
Boarding
8.4
Comfort
8.2
Food
6.7
Entertainment
6.8
Reviews
1 / 17
10.0
ExcellentJames,Oct 2026
RSW - RDU
Overall
8.2
Crew
8.8
Boarding
8.4
Comfort
8.2
Food
6.7
Entertainment
6.8
Reviews
1 / 17
10.0
ExcellentJames,Oct 2026
RSW - RDU
Overall
8.2
Crew
8.8
Boarding
8.4
Comfort
8.2
Food
6.7
Entertainment
6.8
Reviews
1 / 17
10.0
ExcellentJames,Oct 2026
RSW - RDU
Overall
8.2
Crew
8.8
Boarding
8.4
Comfort
8.2
Food
6.7
Entertainment
6.8
Reviews
1 / 17
10.0
ExcellentJames,Oct 2026
RSW - RDU
Related info for your journey
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Alternative routes for Portland to South Carolina
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Complete your trip
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Search flights from Portland to South Carolina by cabin class
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Portland and South Carolina flights
Browse other Portland and South Carolina flight options. Last updated on November 13, 2026.
Popular flight searches
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Portland to South Carolina flights
Consider these flights traveling from Portland to South Carolina.
Top 5 airlines flying from Portland to South Carolina
Discover the top 5 airlines that operate flights from Portland to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$123 | Average$277 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$138 | Average$398 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$198 | Average$367 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$229 | Average$426 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$234 | Average$415 | FlexibilityNo cancel fee | On-time71% |