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$421+ Cheap flights from Louisville to Florence, SC (SDF - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/26. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — FLO
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Louisville to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Louisville (SDF) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$421
(American Airlines)
From Louisville Intl to Florence
Search Deals

Find flight deals from Louisville to Florence

Cheapest flights from Louisville to Florence
Explore the most affordable flight options available from Louisville to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/266:25 amSDF - FLO
1 stop4h 20mAmerican Airlines
Wed 12/310:28 amFLO - SDF
1 stop5h 07mAmerican Airlines
Deal found 9/14$421
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/108:08 pmSDF - FLO
1 stop3h 55mAmerican Airlines
Sun 10/1211:11 amFLO - SDF
1 stop3h 55mAmerican Airlines
Deal found 9/14$519

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisville to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Louisville to Florence that are best for you.

Fly from

Louisville

Fly to

Florence

Route

Depart

Return

Price

LouisvilleFlorence

SDF - FLO

SDFFLO

Louisville Intl

Wed 11/26

6:25 am-10:45 am

1 stop4h 20m

Florence

Wed 12/3

10:28 am-3:35 pm

1 stop5h 07m

$421

LouisvilleFlorence

SDF - FLO

SDFFLO

Louisville Intl

Fri 10/10

8:08 pm-12:03 am

1 stop3h 55m

Florence

Sun 10/12

11:11 am-3:06 pm

1 stop3h 55m

$519

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Best time to book a flight from Louisville to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Louisville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisville to Florence

What is the cheapest month to book a flight from Louisville to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Louisville to Florence, South Carolina (average of $366). Flying from Louisville to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Louisville to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Louisville to Florence, South Carolina?

    American Airlines can get you from Louisville to Florence, South Carolina in just under 4h 20m. Your travel time can differ by up to . Louisville and Florence, South Carolina are separated by a distance of 434 mi.

  • Can I find deals for flights from Louisville to Florence that include hotel bookings?

    Yes. In addition to deals on Louisville to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisville to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to Florence.

  • Can I find deals for business class flights from Louisville to Florence?

    Yes. Cheapflights offers flight deals from Louisville to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisville to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Louisville to Florence, South Carolina (average of $366). Flying from Louisville to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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