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Florence

$241+ Cheap flights from Illinois to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/4. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — FLO
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Illinois to Florence

Keep the following information in mind while searching for Illinois to Florence flight deals. Data was last updated September 15, 2025.

Round-trip from

$241
(American Airlines)
From Illinois to Florence
Search Deals

Find flight deals from Illinois to Florence

Cheapest flights from Illinois to Florence
Explore the most affordable flight options available from Illinois to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/275:00 amORD - FLO
1 stop4h 45mAmerican Airlines
Mon 12/86:15 amFLO - ORD
1 stop5h 27mAmerican Airlines
Deal found 9/14$393
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/305:08 pmORD - FLO
1 stop5h 08mAmerican Airlines
Sat 10/46:14 amFLO - ORD
1 stop5h 29mAmerican Airlines
Deal found 9/15$437
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/159:20 amORD - FLO
1 stop4h 34mAmerican Airlines
Mon 10/2011:11 amFLO - ORD
1 stop5h 54mAmerican Airlines
Deal found 9/15$463
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/157:10 amORD - FLO
1 stop6h 44mAmerican Airlines
Thu 10/235:14 amFLO - ORD
2 stops7h 49mAmerican Airlines
Deal found 9/15$468
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/157:00 amORD - FLO
2 stops6h 54mAmerican Airlines
Tue 10/216:14 amFLO - ORD
2 stops10h 59mAmerican Airlines
Deal found 9/15$473
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/165:22 amORD - FLO
1 stop4h 24mAmerican Airlines
Wed 10/223:19 pmFLO - ORD
2 stops9h 31mAmerican Airlines
Deal found 9/15$490
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/105:15 pmPIA - FLO
1 stop4h 38mAmerican Airlines
Sat 12/136:31 pmFLO - PIA
1 stop6h 36mAmerican Airlines
Deal found 9/13$491
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/181:14 pmORD - FLO
2 stops9h 49mAmerican Airlines
Thu 10/235:14 amFLO - ORD
2 stops9h 38mAmerican Airlines
Deal found 9/15$495
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/26:35 pmORD - FLO
1 stop4h 38mAmerican Airlines
Sun 10/55:14 amFLO - ORD
1 stop5h 11mAmerican Airlines
Deal found 9/14$496
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/296:29 amSTL - FLO
1 stop4h 33mAmerican Airlines
Fri 10/35:37 pmFLO - STL
1 stop16h 39mAmerican Airlines
Deal found 9/14$786

Cheapflights Fare Finder

 
Customize your flight search to find flights from Illinois to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Illinois to Florence that are best for you.

Fly from

Illinois

Fly to

Florence

Route

Depart

Return

Price

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Tue 11/4

5:40 pm-9:54 am

2 stops15h 14m

Florence

Thu 11/6

5:15 am-2:53 pm

2 stops10h 38m

$241

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 11/27

5:00 am-10:45 am

1 stop4h 45m

Florence

Mon 12/8

6:15 am-10:42 am

1 stop5h 27m

$393

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 10/23

6:36 pm-12:03 am

1 stop4h 27m

Florence

Sun 10/26

5:14 am-9:29 am

1 stop5h 15m

$393

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Tue 9/30

3:33 pm-11:16 pm

2 stops6h 43m

Florence

Sat 10/4

6:14 am-11:06 am

2 stops5h 52m

$447

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 10/18

5:20 am-10:46 am

1 stop4h 26m

Florence

Tue 10/21

6:14 am-9:30 am

1 stop4h 16m

$463

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Fri 10/17

5:22 am-10:46 am

1 stop4h 24m

Florence

Mon 10/20

2:29 pm-7:11 pm

1 stop5h 42m

$463

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 10/15

8:35 am-2:54 pm

1 stop5h 19m

Florence

Wed 10/22

3:19 pm-9:10 pm

1 stop6h 51m

$463

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 10/18

5:20 am-10:46 am

1 stop4h 26m

Florence

Mon 10/20

11:11 am-4:05 pm

1 stop5h 54m

$463

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 10/16

5:22 am-10:46 am

1 stop4h 24m

Florence

Mon 10/20

11:11 am-7:34 pm

2 stops9h 23m

$468

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sun 10/19

7:10 am-2:04 pm

1 stop5h 54m

Florence

Tue 10/21

6:14 am-4:13 pm

2 stops10h 59m

$468

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 13 results
1
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Best time to book a flight from Illinois to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Illinois with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Illinois to Florence

What is the cheapest month to book a flight from Illinois to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Illinois to Florence, South Carolina (average of $366). Flying from Illinois to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Illinois to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Illinois?

    Most people fly into Florence (FLO) if they book a flight to Florence from Illinois. Florence is conveniently located just 2.3 mi from Florence’s city center.

  • How long is the flight from Illinois to Florence, South Carolina?

    American Airlines can get you from Illinois to Florence, South Carolina in just under 15h 14m. Your travel time can differ by up to . Illinois and Florence, South Carolina are separated by a distance of 669 mi.

  • What are the most popular routes from Illinois to Florence, South Carolina?

    The most popular route from Illinois to Florence, South Carolina is Chicago O'Hare Intl - Florence. You may also consider Lambert-St Louis - Florence or Moline Quad-City - Florence.

  • Can I find deals for flights from Illinois to Florence that include hotel bookings?

    Yes. In addition to deals on Illinois to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Illinois to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Illinois to Florence.

  • Can I find deals for business class flights from Illinois to Florence?

    Yes. Cheapflights offers flight deals from Illinois to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Illinois to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Illinois to Florence, South Carolina (average of $366). Flying from Illinois to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Top airline flying from Illinois to Florence

Discover the top airline that operate flights from Illinois to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$290Average$437FlexibilityNo cancel feeOn-time71%

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