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Florence

$336+ Cheap flights from Illinois to Florence, SC (FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/18. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — FLO
Mar 13 — Mar 201
Fri 3/13
Fri 3/20
1 adult, Economy
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Cheap flight deals from Illinois to Florence

Cheapest flights from Illinois to Florence
Explore the most affordable flight options available from Illinois to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 11, 2026.

This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:57 pm
STL
-
FLO
1 stop4h 00m
American Airlines
Mon 3/25:16 am
FLO
-
STL
1 stop4h 19m
American Airlines
Deal found 2/11$373
This American Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:41 pm
ORD
-
FLO
1 stop4h 12m
American Airlines
Tue 4/284:02 pm
FLO
-
ORD
1 stop4h 20m
American Airlines
Deal found 2/9$401
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/108:39 am
ORD
-
FLO
1 stop6h 11m
American Airlines
Sun 4/125:24 am
FLO
-
ORD
1 stop4h 06m
American Airlines
Deal found 2/8$413
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:41 pm
ORD
-
FLO
1 stop4h 12m
American Airlines
Mon 5/252:35 pm
FLO
-
ORD
1 stop4h 07m
American Airlines
Deal found 2/10$421
This American Airlines deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2110:28 am
ORD
-
FLO
1 stop6h 22m
American Airlines
Wed 2/256:15 am
FLO
-
ORD
1 stop5h 48m
American Airlines
Deal found 2/8$480
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/1312:36 pm
MLI
-
FLO
1 stop4h 14m
American Airlines
Mon 2/166:20 pm
FLO
-
MLI
1 stop4h 38m
American Airlines
Deal found 2/10$535
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1111:28 am
MLI
-
FLO
2 stops10h 15m
American Airlines
Tue 2/176:15 am
FLO
-
MLI
1 stop6h 56m
American Airlines
Deal found 2/10$586
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1111:28 am
MLI
-
FLO
2 stops10h 15m
American Airlines
Sun 2/156:20 pm
FLO
-
MLI
1 stop4h 38m
American Airlines
Deal found 2/10$591
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/1212:36 pm
MLI
-
FLO
1 stop4h 14m
American Airlines
Sun 2/155:16 am
FLO
-
MLI
2 stops10h 47m
American Airlines
Deal found 2/10$596
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/121:30 pm
MLI
-
FLO
2 stops9h 27m
American Airlines
Wed 2/186:15 am
FLO
-
MLI
2 stops8h 06m
American Airlines
Deal found 2/10$597
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/121:30 pm
MLI
-
FLO
2 stops9h 27m
American Airlines
Thu 2/195:16 am
FLO
-
MLI
2 stops8h 44m
American Airlines
Deal found 2/10$601
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/116:00 am
MLI
-
FLO
2 stops10h 09m
American Airlines
Fri 2/136:20 pm
FLO
-
MLI
1 stop4h 38m
American Airlines
Deal found 2/10$602

Find flight deals from Illinois to Florence

Keep the following information in mind while searching for Illinois to Florence flight deals. Data was last updated February 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$373
(American Airlines)

One-way from

$336
(American Airlines)
Provider with most accurate pricing for Chicago (CHI)-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Chicago (CHI)-Florence flights.
Search Deals
From Illinois to Florence
Search Deals
One-way flight from Illinois to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Illinois to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 11, 2026.
Use the filters below to find and compare flights from Illinois to Florence that are best for you.

Fly from

Illinois

Fly to

Florence

Route

Depart

Return

Price

St. LouisFlorence

STL - FLO

STLFLO

Lambert-St Louis

Thu 2/26

6:57 pm-11:57 pm

1 stop4h 00m

Florence

Mon 3/2

5:16 am-8:35 am

1 stop4h 19m

$373

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Fri 4/24

6:41 pm-11:53 pm

1 stop4h 12m

Florence

Tue 4/28

4:02 pm-7:22 pm

1 stop4h 20m

$401

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Fri 4/10

8:39 am-3:50 pm

1 stop6h 11m

Florence

Sun 4/12

5:24 am-8:30 am

1 stop4h 06m

$413

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 5/16

6:41 pm-11:53 pm

1 stop4h 12m

Florence

Mon 5/25

2:35 pm-5:42 pm

1 stop4h 07m

$421

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sat 2/21

10:28 am-5:50 pm

1 stop6h 22m

Florence

Wed 2/25

6:15 am-11:03 am

1 stop5h 48m

$480

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Wed 2/18

10:28 am-5:21 pm

1 stop5h 53m

$336

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/11

Best time to book a flight from Illinois to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Illinois with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Illinois to Florence

What is the cheapest month to book a flight from Illinois to Florence, South Carolina?

Currently, December is the cheapest month in which you can book a flight from Illinois to Florence, South Carolina (average of $56). Flying from Illinois to Florence, South Carolina in April is currently the most expensive (average of $112). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Illinois to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Illinois?

    Most people fly into Florence (FLO) if they book a flight to Florence from Illinois. Florence is conveniently located just 2.3 mi from Florence’s city center.

  • How long is the flight from Illinois to Florence, South Carolina?

    American Airlines can get you from Illinois to Florence, South Carolina in just under 4h. Your travel time can differ by up to . Illinois and Florence, South Carolina are separated by a distance of 669 mi.

  • What are the most popular routes from Illinois to Florence, South Carolina?

    The most popular route from Illinois to Florence, South Carolina is Chicago O'Hare Intl - Florence. You may also consider Moline Quad-City - Florence or Lambert-St Louis - Florence.

  • Can I find deals for flights from Illinois to Florence that include hotel bookings?

    Yes. In addition to deals on Illinois to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Illinois to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Illinois to Florence.

  • Can I find deals for business class flights from Illinois to Florence?

    Yes. Cheapflights offers flight deals from Illinois to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Illinois to Florence, South Carolina?

    Currently, December is the cheapest month in which you can book a flight from Illinois to Florence, South Carolina (average of $56). Flying from Illinois to Florence, South Carolina in April is currently the most expensive (average of $112). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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