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$457+ Cheap flights from Illinois to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/20. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — FLO
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Cheap flight deals from Illinois to Florence

Keep the following information in mind while searching for Illinois to Florence flight deals. Data was last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$457
(American Airlines)
Provider with most accurate pricing for Chicago (CHI)-Florence flight deals.
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Provider most trusted by Cheapflights users for Chicago (CHI)-Florence flights.
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From Illinois to Florence
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Find flight deals from Illinois to Florence

Cheapest flights from Illinois to Florence
Explore the most affordable flight options available from Illinois to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/205:00 amORD - FLO
1 stop4h 45mAmerican Airlines
Mon 11/245:35 pmFLO - ORD
1 stop7h 02mAmerican Airlines
Deal found 11/5$457
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/214:05 pmORD - FLO
1 stop7h 10mAmerican Airlines
Sun 12/285:15 amFLO - ORD
1 stop6h 30mAmerican Airlines
Deal found 11/6$463
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/105:15 pmPIA - FLO
1 stop4h 38mAmerican Airlines
Sat 12/136:31 pmFLO - PIA
1 stop6h 36mAmerican Airlines
Deal found 11/4$491
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/95:00 amORD - FLO
1 stop4h 45mAmerican Airlines
Tue 11/1111:14 amFLO - ORD
1 stop4h 43mAmerican Airlines
Deal found 11/5$892

Cheapflights Fare Finder

 
Customize your flight search to find flights from Illinois to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Illinois to Florence that are best for you.

Fly from

Illinois

Fly to

Florence

Route

Depart

Return

Price

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Thu 11/20

5:00 am-10:45 am

1 stop4h 45m

Florence

Mon 11/24

5:35 pm-11:37 pm

1 stop7h 02m

$457

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Sun 12/21

4:05 pm-12:15 am

1 stop7h 10m

Florence

Sun 12/28

5:15 am-10:45 am

1 stop6h 30m

$463

PeoriaFlorence

PIA - FLO

PIAFLO

Greater Peoria

Wed 12/10

5:15 pm-10:53 pm

1 stop4h 38m

Florence

Sat 12/13

6:31 pm-12:07 am

1 stop6h 36m

$491

MolineFlorence

MLI - FLO

MLIFLO

Moline Quad-City

Wed 3/11

4:30 pm-11:38 pm

1 stop6h 08m

Florence

Sat 3/14

11:09 am-3:48 pm

1 stop5h 39m

$497

ChicagoFlorence

ORD - FLO

ORDFLO

Chicago O'Hare Intl

Tue 3/17

7:00 am-2:05 pm

1 stop6h 05m

Florence

Sat 3/21

5:13 am-8:32 am

1 stop4h 19m

$504

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/5

Best time to book a flight from Illinois to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Illinois with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Illinois to Florence

What is the cheapest month to book a flight from Illinois to Florence, South Carolina?

Currently, February is the cheapest month in which you can book a flight from Illinois to Florence, South Carolina (average of $52). Flying from Illinois to Florence, South Carolina in April is currently the most expensive (average of $124). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Illinois to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Illinois?

    Most people fly into Florence (FLO) if they book a flight to Florence from Illinois. Florence is conveniently located just 2.3 mi from Florence’s city center.

  • How long is the flight from Illinois to Florence, South Carolina?

    American Airlines can get you from Illinois to Florence, South Carolina in just under 4h 45m. Your travel time can differ by up to . Illinois and Florence, South Carolina are separated by a distance of 697 mi.

  • What are the most popular routes from Illinois to Florence, South Carolina?

    The most popular route from Illinois to Florence, South Carolina is Chicago O'Hare Intl - Florence. You may also consider Lambert-St Louis - Florence or Moline Quad-City - Florence.

  • Can I find deals for flights from Illinois to Florence that include hotel bookings?

    Yes. In addition to deals on Illinois to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Illinois to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Illinois to Florence.

  • Can I find deals for business class flights from Illinois to Florence?

    Yes. Cheapflights offers flight deals from Illinois to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Illinois to Florence, South Carolina?

    Currently, February is the cheapest month in which you can book a flight from Illinois to Florence, South Carolina (average of $52). Flying from Illinois to Florence, South Carolina in April is currently the most expensive (average of $124). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Top airline flying from Illinois to Florence

Discover the top airline that operate flights from Illinois to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$290Average$471FlexibilityNo cancel feeOn-time71%

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