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$225+ Cheap flights from Florence, SC (FLO) to Illinois

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/11. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — ORD
Aug 5 — Aug 121
Wed 8/5
Wed 8/12
1 adult, Economy
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Cheap flight deals from Florence to Illinois

Cheapest flights from Florence to Illinois
Explore the most affordable flight options available from Florence to Illinois. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 6, 2026.

This American Airlines deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:22 am
FLO
-
ORD
1 stop5h 29m
American Airlines
Mon 8/107:30 am
ORD
-
FLO
1 stop6h 26m
American Airlines
Deal found 7/5$345
This American Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/286:22 am
FLO
-
ORD
1 stop6h 53m
American Airlines
Mon 8/315:49 pm
ORD
-
FLO
1 stop4h 10m
American Airlines
Deal found 7/3$357
This American Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/12:35 pm
FLO
-
ORD
1 stop6h 16m
American Airlines
Fri 8/74:53 pm
ORD
-
FLO
1 stop5h 06m
American Airlines
Deal found 7/3$402
This American Airlines deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/292:35 pm
FLO
-
ORD
1 stop6h 16m
American Airlines
Tue 8/45:45 pm
ORD
-
FLO
1 stop4h 52m
American Airlines
Deal found 7/6$435
This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/175:17 am
FLO
-
ORD
1 stop4h 45m
American Airlines
Sun 7/196:30 am
ORD
-
FLO
1 stop6h 40m
American Airlines
Deal found 7/1$477
This American Airlines deal was found by Cheapflights users on 7/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/42:35 pm
FLO
-
STL
1 stop3h 46m
American Airlines
Mon 8/1010:22 am
STL
-
FLO
1 stop3h 34m
American Airlines
Deal found 7/5$518
This American Airlines deal was found by Cheapflights users on 7/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/173:22 pm
FLO
-
ORD
1 stop7h 35m
American Airlines
Mon 8/248:54 am
ORD
-
FLO
1 stop5h 02m
American Airlines
Deal found 7/3$539
This American Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:34 am
FLO
-
ORD
1 stop5h 31m
American Airlines
Sat 10/312:52 pm
ORD
-
FLO
2 stops8h 05m
American Airlines
Deal found 7/2$574
This American Airlines deal was found by Cheapflights users on 7/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/105:17 am
FLO
-
STL
1 stop4h 16m
American Airlines
Mon 7/136:13 pm
STL
-
FLO
1 stop4h 24m
American Airlines
Deal found 7/6$639
This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/235:17 am
FLO
-
STL
2 stops12h 23m
American Airlines
Sun 8/29:25 am
STL
-
FLO
1 stop3h 45m
American Airlines
Deal found 7/1$664

Find flight deals from Florence to Illinois

Keep the following information in mind while searching for Florence to Illinois flight deals. Data was last updated July 6, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$345
(American Airlines)

One-way from

$225
(American Airlines)
Provider with most accurate pricing for Florence-Chicago (CHI) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Florence-Chicago (CHI) flights.
Search Deals
From Florence to Illinois
Search Deals
One-way flight from Florence to Illinois
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to Illinois that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 6, 2026.
Use the filters below to find and compare flights from Florence to Illinois that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceChicago

FLO - ORD

FLOORD

Florence

Tue 10/27

6:34 am-11:05 am

1 stop5h 31m

Chicago O'Hare Intl

Sat 10/31

6:40 pm-11:57 pm

1 stop4h 17m

$345

FlorenceChicago

FLO - ORD

FLOORD

Florence

Wed 7/29

2:35 pm-7:51 pm

1 stop6h 16m

Chicago O'Hare Intl

Tue 8/4

5:45 pm-11:37 pm

1 stop4h 52m

$435
Quickest round-trip

FlorenceSt. Louis

FLO - STL

FLOSTL

Florence

Tue 8/4

2:35 pm-5:21 pm

1 stop3h 46m

Lambert-St Louis

Mon 8/10

10:22 am-2:56 pm

1 stop3h 34m

$518

FlorenceSt. Louis

FLO - STL

FLOSTL

Florence

Thu 7/23

5:17 am-8:33 am

1 stop4h 16m

Lambert-St Louis

Sun 8/2

6:13 pm-11:37 pm

1 stop4h 24m

$639

FlorenceChicago

FLO - ORD

FLOORD

Florence

Thu 8/6

6:22 am-12:12 pm

2 stops6h 50m

Chicago O'Hare Intl

Mon 8/10

6:49 am-2:56 pm

1 stop7h 07m

$639

FlorenceChicago

FLO - ORD

FLOORD

Florence

Mon 8/17

6:22 am-12:54 pm

2 stops7h 32m

Chicago O'Hare Intl

Mon 8/24

6:49 am-2:56 pm

1 stop7h 07m

$642

FlorenceChicago

FLO - ORD

FLOORD

Florence

Fri 7/17

5:17 am-9:02 am

1 stop4h 45m

Chicago O'Hare Intl

Sun 7/19

6:37 am-2:10 pm

2 stops6h 33m

$705
Cheapest one-way

FlorenceChicago

FLO - ORD

FLOORD

Florence

Sat 7/11

5:17 am-11:00 am

1 stop6h 43m

$225
Quickest one-way

FlorenceChicago

FLO - ORD

FLOORD

Florence

Tue 7/14

2:35 pm-7:51 pm

1 stop6h 16m

$225

FlorenceChicago

FLO - ORD

FLOORD

Florence

Thu 7/16

2:35 pm-7:51 pm

1 stop6h 16m

$274

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/1

Showing 1-10 of 11 resultsSorted by cheapest first
1
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Best time to book a flight from Florence to Illinois

Have a flexible travel schedule? Discover the best time to fly to Illinois from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to Illinois
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Florence to Illinois. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Florence to Illinois?

    Most people fly from Florence (FLO) if they book a flight from Florence to Illinois. Florence is conveniently located just 2.3 mi from Florence’s city center.

  • How long is the flight from Florence, South Carolina to Illinois?

    American Airlines can get you from Florence, South Carolina to Illinois in just under 5h 31m. Your travel time can differ by up to . The distance between Florence, South Carolina and Illinois is about 697 mi.

  • What are the most popular routes from Florence, South Carolina to Illinois?

    When deciding which route to take from Florence, South Carolina to Illinois consider Florence - Chicago O'Hare Intl, Florence - Greater Peoria or Florence - Lambert-St Louis as they are the most popular.

  • Can I find deals for flights from Florence to Illinois that include hotel bookings?

    Yes. In addition to deals on Florence to Illinois flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to Illinois?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to Illinois.

  • Can I find deals for business class flights from Florence to Illinois?

    Yes. Cheapflights offers flight deals from Florence to Illinois by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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