Departing on a Saturday is a good option for securing a great price. You can expect to save up to 36% when planning your travel around this day of the week.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Peoria, Illinois to Florence, South Carolina as you normally would.
This is defined as Greater Peoria Airport (PIA) and Florence Airport (FLO). Codes like Florence Airport are often used to just call airports uniquely.