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Florence

$305+ Cheap flights from Florida to Florence, SC (FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/27. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — FLO
nov. 13 — nov. 201
jue. 11/13
jue. 11/20
1 adult, Economy
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Find flight deals from Florida to Florence

Cheapest flights from Florida to Florence
Explore the most affordable flight options available from Florida to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 14, 2025.

This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/186:48 pmMCO - FLO
1 stop5h 15mAmerican Airlines
sáb. 10/255:14 amFLO - MCO
1 stop5h 28mAmerican Airlines
Deal found 10/13$407
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/295:00 amMCO - FLO
1 stop5h 45mAmerican Airlines
dom. 12/76:31 pmFLO - MCO
1 stop3h 29mAmerican Airlines
Deal found 10/13$451
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/2011:49 amFLL - FLO
1 stop6h 16mAmerican Airlines
sáb. 12/276:30 pmFLO - FLL
1 stop5h 54mAmerican Airlines
Deal found 10/13$457
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/15:30 pmMCO - FLO
1 stop6h 11mAmerican Airlines
mar. 12/96:15 amFLO - MCO
1 stop4h 38mAmerican Airlines
Deal found 10/12$458
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/97:56 pmSRQ - FLO
1 stop4h 07mAmerican Airlines
mar. 11/186:15 amFLO - SRQ
1 stop5h 32mAmerican Airlines
Deal found 10/12$462
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/299:37 amMCO - FLO
1 stop5h 17mAmerican Airlines
dom. 11/26:32 pmFLO - MCO
1 stop5h 52mAmerican Airlines
Deal found 10/13$472
This American Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/299:19 amTPA - FLO
1 stop5h 35mAmerican Airlines
dom. 11/26:32 pmFLO - TPA
1 stop5h 40mAmerican Airlines
Deal found 10/14$472
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/248:28 amMCO - FLO
1 stop6h 26mAmerican Airlines
dom. 10/262:29 pmFLO - MCO
1 stop4h 22mAmerican Airlines
Deal found 10/12$477
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 11/96:00 amMIA - FLO
1 stop4h 45mAmerican Airlines
dom. 11/165:15 amFLO - MIA
1 stop3h 55mAmerican Airlines
Deal found 10/12$500

Cheap flight deals from Florida to Florence

Keep the following information in mind while searching for Florida to Florence flight deals. Data was last updated octubre 14, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$407
(American Airlines)

One-way from

$305
(American Airlines)
Provider with most accurate pricing for Orlando (ORL)-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Orlando (ORL)-Florence flights.
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From Florida to Florence
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One-way flight from Florida to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 14, 2025.
Use the filters below to find and compare flights from Florida to Florence that are best for you.

Fly from

Florida

Fly to

Florence

Route

Depart

Return

Price

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

sáb. 10/18

6:48 pm-12:03 am

1 stop5h 15m

Florence

sáb. 10/25

5:14 am-10:42 am

1 stop5h 28m

$407

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

sáb. 11/29

5:00 am-10:45 am

1 stop5h 45m

Florence

dom. 12/7

6:31 pm-10:00 pm

1 stop3h 29m

$451

West Palm BeachFlorence

PBI - FLO

PBIFLO

Palm Beach Intl

sáb. 4/4

10:24 am-2:05 pm

1 stop3h 41m

Florence

mar. 4/7

5:13 am-8:58 am

1 stop3h 45m

$457

Fort LauderdaleFlorence

FLL - FLO

FLLFLO

Fort Lauderdale

sáb. 12/20

11:49 am-6:05 pm

1 stop6h 16m

Florence

sáb. 12/27

6:30 pm-12:24 am

1 stop5h 54m

$457

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

lun. 12/1

5:30 pm-11:41 pm

1 stop6h 11m

Florence

mar. 12/9

6:15 am-10:53 am

1 stop4h 38m

$458

SarasotaFlorence

SRQ - FLO

SRQFLO

Sarasota Bradenton Intl

dom. 11/9

7:56 pm-12:03 am

1 stop4h 07m

Florence

mar. 11/18

6:15 am-11:47 am

1 stop5h 32m

$462

SarasotaFlorence

SRQ - FLO

SRQFLO

Sarasota Bradenton Intl

mar. 3/24

8:02 pm-11:38 pm

1 stop3h 36m

Florence

sáb. 3/28

2:30 pm-6:09 pm

1 stop3h 39m

$467

TampaFlorence

TPA - FLO

TPAFLO

Tampa

mié. 10/29

9:19 am-2:54 pm

1 stop5h 35m

Florence

dom. 11/2

6:32 pm-12:12 am

1 stop5h 40m

$472

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

vie. 10/24

8:28 am-2:54 pm

1 stop6h 26m

Florence

dom. 10/26

2:29 pm-6:51 pm

1 stop4h 22m

$477

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

mié. 10/29

8:28 am-2:54 pm

1 stop6h 26m

Florence

dom. 11/2

5:15 am-2:11 pm

2 stops8h 56m

$477

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/14

Showing 1-10 of 15 results
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Best time to book a flight from Florida to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Florida with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida to Florence

What is the cheapest month to book a flight from Florida to Florence, South Carolina?

Currently, December is the cheapest month in which you can book a flight from Florida to Florence, South Carolina (average of $37). Flying from Florida to Florence, South Carolina in July is currently the most expensive (average of $74). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from FL to FLO?

Find hourly flight availability from Florida to Florence. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octubre 14, 2025.

It’s typically best to fly out from Florida to Florence, South Carolina in the morning. Doing so could potentially save you 25% on the flight price compared to flying at noon, which is usually more expensive.

Related info for your journey

Find useful and relevant information for your journey from Florida to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Florida?

    Florence (FLO) is the airport you will fly into if you book a flight from Florida to Florence. It is only a 2.3 mi journey from Florence (FLO) to Florence’s city center.

  • How long is the flight from Florida to Florence, South Carolina?

    There are many flights that can get you from Florida to Florence, South Carolina in 5h 15m. Fly via American Airlines to get the fastest option. Florida and Florence, South Carolina are separated by a distance of 408 mi.

  • What are the most popular routes from Florida to Florence, South Carolina?

    When deciding which route to take from Florida to Florence, South Carolina consider Orlando - Florence, Palm Beach Intl - Florence or Fort Lauderdale - Florence as they are the most popular.

  • Can I find deals for flights from Florida to Florence that include hotel bookings?

    Yes. In addition to deals on Florida to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida to Florence.

  • Can I find deals for business class flights from Florida to Florence?

    Yes. Cheapflights offers flight deals from Florida to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florida to Florence, South Carolina?

    Currently, December is the cheapest month in which you can book a flight from Florida to Florence, South Carolina (average of $37). Flying from Florida to Florence, South Carolina in July is currently the most expensive (average of $74). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Alternative routes for Florida to Florence

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Florida to Florence

Discover the top airline that operate flights from Florida to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$371Average$481FlexibilityNo cancel feeOn-time71%

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