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Florence

$271+ Cheap flights from Florida to Florence, SC (FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/25. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — FLO
Dec 30 — Jan 61
Tue 12/30
Tue 1/6
1 adult, Economy
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Find flight deals from Florida to Florence

Cheapest flights from Florida to Florence
Explore the most affordable flight options available from Florida to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 30, 2025.

This American Airlines deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/258:25 amTPA - FLO
1 stop4h 01mAmerican Airlines
Mon 12/295:15 amFLO - TPA
1 stop4h 26mAmerican Airlines
Deal found 11/29$412
This American Airlines deal was found by Cheapflights users on 11/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/202:04 pmTPA - FLO
1 stop4h 01mAmerican Airlines
Fri 1/26:30 pmFLO - TPA
1 stop3h 30mAmerican Airlines
Deal found 11/28$441
This American Airlines deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:00 amMCO - FLO
1 stop3h 50mAmerican Airlines
Sat 1/31:07 pmFLO - MCO
1 stop5h 01mAmerican Airlines
Deal found 11/29$477
This American Airlines deal was found by Cheapflights users on 11/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2012:09 pmTPA - FLO
1 stop5h 56mAmerican Airlines
Sat 1/35:15 amFLO - TPA
1 stop4h 26mAmerican Airlines
Deal found 11/28$477
This American Airlines deal was found by Cheapflights users on 11/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:00 amMIA - FLO
1 stop6h 26mAmerican Airlines
Sun 1/45:15 amFLO - MIA
1 stop4h 10mAmerican Airlines
Deal found 11/28$479
This American Airlines deal was found by Cheapflights users on 11/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/197:25 amTPA - FLO
1 stop5h 01mAmerican Airlines
Wed 12/3112:51 pmFLO - TPA
1 stop5h 58mAmerican Airlines
Deal found 11/28$482
This American Airlines deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/49:05 amMCO - FLO
2 stops9h 00mAmerican Airlines
Sat 1/31:07 pmFLO - MCO
1 stop3h 33mAmerican Airlines
Deal found 11/29$487
This American Airlines deal was found by Cheapflights users on 11/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/202:24 pmTPA - FLO
2 stops9h 51mAmerican Airlines
Wed 12/3112:51 pmFLO - TPA
2 stops9h 09mAmerican Airlines
Deal found 11/28$496
This American Airlines deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:00 amMCO - FLO
1 stop3h 50mAmerican Airlines
Sun 1/46:30 pmFLO - MCO
1 stop3h 30mAmerican Airlines
Deal found 11/29$501
This American Airlines deal was found by Cheapflights users on 11/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/208:25 amTPA - FLO
1 stop4h 01mAmerican Airlines
Sun 1/41:07 pmFLO - TPA
1 stop5h 42mAmerican Airlines
Deal found 11/28$501
This American Airlines deal was found by Cheapflights users on 11/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/47:40 pmMCO - FLO
1 stop4h 23mAmerican Airlines
Sun 1/45:15 amFLO - MCO
1 stop5h 31mAmerican Airlines
Deal found 11/29$506
This American Airlines deal was found by Cheapflights users on 11/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:00 amTPA - FLO
1 stop6h 26mAmerican Airlines
Sun 1/46:30 pmFLO - TPA
1 stop5h 47mAmerican Airlines
Deal found 11/28$506

Cheap flight deals from Florida to Florence

Keep the following information in mind while searching for Florida to Florence flight deals. Data was last updated November 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$411
(American Airlines)

One-way from

$271
(American Airlines)
Provider with most accurate pricing for Orlando (ORL)-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Orlando (ORL)-Florence flights.
Search Deals
From Florida to Florence
Search Deals
One-way flight from Florida to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 30, 2025.
Use the filters below to find and compare flights from Florida to Florence that are best for you.

Fly from

Florida

Fly to

Florence

Route

Depart

Return

Price

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Sat 2/14

6:40 am-11:58 pm

2 stops17h 18m

Florence

Wed 2/18

6:15 am-8:18 pm

2 stops14h 03m

$426

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sat 12/20

2:04 pm-6:05 pm

1 stop4h 01m

Florence

Fri 1/2

6:30 pm-10:00 pm

1 stop3h 30m

$441

SarasotaFlorence

SRQ - FLO

SRQFLO

Sarasota Bradenton Intl

Sat 2/21

7:43 pm-11:58 pm

1 stop4h 15m

Florence

Tue 2/24

5:58 pm-9:44 pm

1 stop3h 46m

$447

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Wed 1/28

12:01 pm-5:09 pm

1 stop5h 08m

Florence

Sat 1/31

6:15 am-1:12 pm

1 stop6h 57m

$447

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sat 2/14

12:07 pm-5:49 pm

1 stop5h 42m

Florence

Wed 2/18

6:15 am-12:26 pm

1 stop6h 11m

$447

Fort MyersFlorence

RSW - FLO

RSWFLO

Fort Myers SW Florida Intl

Wed 1/7

11:10 am-5:09 pm

1 stop5h 59m

Florence

Sat 1/10

5:36 pm-11:58 pm

1 stop6h 22m

$457

West Palm BeachFlorence

PBI - FLO

PBIFLO

Palm Beach Intl

Wed 1/7

11:36 am-5:09 pm

1 stop5h 33m

Florence

Sat 1/10

5:36 pm-9:20 pm

1 stop3h 44m

$457

MiamiFlorence

MIA - FLO

MIAFLO

Miami

Wed 1/14

8:12 am-10:43 pm

2 stops14h 31m

Florence

Sat 1/17

5:36 pm-8:53 am

2 stops15h 17m

$466

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Wed 12/3

6:00 am-9:50 am

1 stop3h 50m

Florence

Sat 1/3

1:07 pm-6:08 pm

1 stop5h 01m

$477

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sat 12/20

12:09 pm-6:05 pm

1 stop5h 56m

Florence

Sat 1/3

5:15 am-9:41 am

1 stop4h 26m

$477

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/27

Showing 1-10 of 22 results
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Best time to book a flight from Florida to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Florida with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida to Florence

What is the cheapest month to book a flight from Florida to Florence, South Carolina?

Currently, November is the cheapest month in which you can book a flight from Florida to Florence, South Carolina (average of $36). Flying from Florida to Florence, South Carolina in July is currently the most expensive (average of $74). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from FL to FLO?

Find hourly flight availability from Florida to Florence. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 30, 2025.

It’s typically best to fly out from Florida to Florence, South Carolina in the morning. Doing so could potentially save you 25% on the flight price compared to flying at noon, which is usually more expensive.

Related info for your journey

Find useful and relevant information for your journey from Florida to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Florida?

    Florence (FLO) is the airport you will fly into if you book a flight from Florida to Florence. It is only a 2.3 mi journey from Florence (FLO) to Florence’s city center.

  • How long is the flight from Florida to Florence, South Carolina?

    There are many flights that can get you from Florida to Florence, South Carolina in 17h 18m. Fly via American Airlines to get the fastest option. Florida and Florence, South Carolina are separated by a distance of 408 mi.

  • What are the most popular routes from Florida to Florence, South Carolina?

    When deciding which route to take from Florida to Florence, South Carolina consider Orlando - Florence, Miami - Florence or Tampa - Florence as they are the most popular.

  • Can I find deals for flights from Florida to Florence that include hotel bookings?

    Yes. In addition to deals on Florida to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida to Florence.

  • Can I find deals for business class flights from Florida to Florence?

    Yes. Cheapflights offers flight deals from Florida to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florida to Florence, South Carolina?

    Currently, November is the cheapest month in which you can book a flight from Florida to Florence, South Carolina (average of $36). Flying from Florida to Florence, South Carolina in July is currently the most expensive (average of $74). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Alternative routes for Florida to Florence

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Florida to Florence

Discover the top airline that operate flights from Florida to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$402Average$519FlexibilityNo cancel feeOn-time71%

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