HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$356+ Cheap flights from Florida to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/27. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — FLO
ago. 19 — ago. 261
mar. 8/19
mar. 8/26
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Florida to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Florida to Florence

Keep the following information in mind while searching for Florida to Florence flight deals. Data was last updated agosto 14, 2025.

Round-trip from

$356
(American Airlines)
From Florida to Florence
Search Deals

Find flight deals from Florida to Florence

Cheapest flights from Florida to Florence
Explore the most affordable flight options available from Florida to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 14, 2025.

This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/2712:11 pmMCO - FLO
2 stops11h 05mAmerican Airlines
sáb. 10/46:14 amFLO - MCO
2 stops13h 30mAmerican Airlines
Deal found 8/14$356
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/307:06 amMCO - FLO
2 stops10h 19mAmerican Airlines
mié. 9/36:14 amFLO - MCO
2 stops13h 30mAmerican Airlines
Deal found 8/14$366
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/711:43 amTPA - FLO
2 stops11h 30mAmerican Airlines
mar. 10/146:14 amFLO - TPA
2 stops11h 50mAmerican Airlines
Deal found 8/14$378
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/275:43 amMIA - FLO
1 stop4h 30mAmerican Airlines
sáb. 12/62:29 pmFLO - MIA
1 stop7h 13mAmerican Airlines
Deal found 8/13$403
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 9/2811:49 amMCO - FLO
1 stop4h 43mAmerican Airlines
dom. 10/54:57 pmFLO - MCO
1 stop4h 02mAmerican Airlines
Deal found 8/14$440
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 8/139:50 amTPA - FLO
1 stop5h 14mAmerican Airlines
sáb. 8/1611:15 amFLO - TPA
1 stop3h 27mAmerican Airlines
Deal found 8/12$467
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/297:44 pmSRQ - FLO
1 stop4h 06mAmerican Airlines
mar. 9/23:30 pmFLO - SRQ
1 stop6h 16mAmerican Airlines
Deal found 8/14$472
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/296:15 amMCO - FLO
1 stop4h 24mAmerican Airlines
mar. 9/212:11 pmFLO - MCO
1 stop3h 47mAmerican Airlines
Deal found 8/13$472
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/286:00 amPBI - FLO
1 stop4h 50mAmerican Airlines
lun. 9/15:09 amFLO - PBI
1 stop5h 58mAmerican Airlines
Deal found 8/13$477
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/287:46 amFLL - FLO
1 stop6h 23mAmerican Airlines
dom. 8/312:34 pmFLO - FLL
1 stop6h 48mAmerican Airlines
Deal found 8/14$477
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/267:05 amMIA - FLO
1 stop4h 57mAmerican Airlines
dom. 9/2811:18 amFLO - MIA
1 stop5h 29mAmerican Airlines
Deal found 8/13$479
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/117:37 pmMIA - FLO
1 stop4h 36mAmerican Airlines
jue. 9/185:14 amFLO - MIA
1 stop5h 52mAmerican Airlines
Deal found 8/14$500

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 14, 2025.
Use the filters below to find and compare flights from Florida to Florence that are best for you.

Fly from

Florida

Fly to

Florence

Route

Depart

Return

Price

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

sáb. 9/27

12:11 pm-11:16 pm

2 stops11h 05m

Florence

sáb. 10/4

6:14 am-7:44 pm

2 stops13h 30m

$356

TampaFlorence

TPA - FLO

TPAFLO

Tampa

mar. 10/7

11:43 am-11:13 pm

2 stops11h 30m

Florence

mar. 10/14

6:14 am-6:04 pm

2 stops11h 50m

$378

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

dom. 9/28

11:49 am-4:32 pm

1 stop4h 43m

Florence

dom. 10/5

4:57 pm-8:59 pm

1 stop4h 02m

$440

SarasotaFlorence

SRQ - FLO

SRQFLO

Sarasota Bradenton Intl

vie. 8/29

7:44 pm-11:50 pm

1 stop4h 06m

Florence

mar. 9/2

3:30 pm-9:46 pm

1 stop6h 16m

$472

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

vie. 8/29

6:15 am-10:39 am

1 stop4h 24m

Florence

mar. 9/2

12:11 pm-3:58 pm

1 stop3h 47m

$472

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

jue. 9/11

11:49 am-4:32 pm

1 stop4h 43m

Florence

jue. 9/18

4:57 pm-10:24 pm

1 stop5h 27m

$477

West Palm BeachFlorence

PBI - FLO

PBIFLO

Palm Beach Intl

jue. 8/28

6:00 am-10:50 am

1 stop4h 50m

Florence

lun. 9/1

5:09 am-11:07 am

1 stop5h 58m

$477

Fort LauderdaleFlorence

FLL - FLO

FLLFLO

Fort Lauderdale

jue. 8/28

7:46 am-2:09 pm

1 stop6h 23m

Florence

dom. 8/31

2:34 pm-9:22 pm

1 stop6h 48m

$477

Fort LauderdaleFlorence

FLL - FLO

FLLFLO

Fort Lauderdale

jue. 8/28

7:46 am-2:09 pm

1 stop6h 23m

Florence

lun. 9/1

5:09 am-9:00 am

1 stop3h 51m

$477

Fort LauderdaleFlorence

FLL - FLO

FLLFLO

Fort Lauderdale

vie. 8/29

5:33 pm-11:50 pm

1 stop6h 17m

Florence

dom. 8/31

2:34 pm-9:22 pm

1 stop6h 48m

$477

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/14

Showing 1-10 of 16 results
1
2

Best time to book a flight from Florida to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Florida with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida to Florence

What is the cheapest month to book a flight from Florida to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Florida to Florence, South Carolina (average of $366). Flying from Florida to Florence, South Carolina in October is currently the most expensive (average of $489). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from FL to FLO?

Find hourly flight availability from Florida to Florence. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated agosto 14, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Florida to Florence, South Carolina as you normally would.

Related info for your journey

Find useful and relevant information for your journey from Florida to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Florida?

    Florence (FLO) is the airport you will fly into if you book a flight from Florida to Florence. It is only a 2.3 mi journey from Florence (FLO) to Florence’s city center.

  • What are the most popular routes from Florida to Florence, South Carolina?

    When deciding which route to take from Florida to Florence, South Carolina consider Fort Lauderdale - Florence, Orlando - Florence or Miami - Florence as they are the most popular.

  • Can I find deals for flights from Florida to Florence that include hotel bookings?

    Yes. In addition to deals on Florida to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida to Florence.

  • Can I find deals for business class flights from Florida to Florence?

    Yes. Cheapflights offers flight deals from Florida to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florida to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Florida to Florence, South Carolina (average of $366). Flying from Florida to Florence, South Carolina in October is currently the most expensive (average of $489). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Florida to Florence

See prices for flight routes from nearby airports that may be better suited for you.
Newark to Charlotte flights
John F Kennedy Intl to Charleston flights
LaGuardia to Charlotte flights
John F Kennedy Intl to Charlotte flights
Newark to Myrtle Beach flights
Newark to Charleston flights
LaGuardia to Charleston flights
Dulles Intl to Charleston flights
Boston to Charleston flights
Denver to Charlotte flights
Dallas/Fort Worth to Charlotte flights
Boston to Charlotte flights
LaGuardia to Myrtle Beach flights
O'Hare Intl to Charleston flights
John F Kennedy Intl to Savannah flights
O'Hare Intl to Charlotte flights
Baltimore to Charlotte flights
John F Kennedy Intl to Myrtle Beach flights
Dulles Intl to Charlotte flights
O'Hare Intl to Savannah flights
Newark to Savannah flights
Newark to Greenville flights
Reagan-National to Charleston flights
Philadelphia to Charleston flights
Minneapolis to Charlotte flights
Hobby to Charlotte flights
Minneapolis to Charleston flights
Los Angeles to Charlotte flights
Baltimore to Charleston flights
Fort Lauderdale to Charlotte flights
Philadelphia to Savannah flights
LaGuardia to Savannah flights
Boston to Myrtle Beach flights
George Bush Intcntl to Charlotte flights
LaGuardia to Greenville flights
Boston to Savannah flights
White Plains to Charleston flights
Miami to Charlotte flights
Baltimore to Myrtle Beach flights
Reagan-National to Charlotte flights
John F Kennedy Intl to Greenville flights
Denver to Charleston flights
Philadelphia to Charlotte flights
O'Hare Intl to Myrtle Beach flights
Minneapolis to Savannah flights
Dallas/Fort Worth to Charleston flights
Dulles Intl to Savannah flights
Seattle to Charleston flights
Denver to Savannah flights
Dulles Intl to Greenville flights

Top airline flying from Florida to Florence

Discover the top airline that operate flights from Florida to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$315Average$493FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.