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Florence

$324+ Cheap flights from Florida to Florence, SC (FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/30. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — FLO
Feb 13 — Feb 201
Fri 2/13
Fri 2/20
1 adult, Economy
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Cheap flight deals from Florida to Florence

Keep the following information in mind while searching for Florida to Florence flight deals. Data was last updated January 14, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$387
(American Airlines)

One-way from

$324
(American Airlines)
Provider with most accurate pricing for Orlando (ORL)-Florence flight deals.
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Provider most trusted by Cheapflights users for Orlando (ORL)-Florence flights.
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From Florida to Florence
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One-way flight from Florida to Florence
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Find flight deals from Florida to Florence

Cheapest flights from Florida to Florence
Explore the most affordable flight options available from Florida to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 14, 2026.

This American Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/114:28 pm
MCO
-
FLO
1 stop6h 15m
American Airlines
Wed 2/185:58 pm
FLO
-
MCO
1 stop5h 49m
American Airlines
Deal found 1/12$387
This American Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/117:35 pm
TPA
-
FLO
1 stop4h 22m
American Airlines
Wed 3/186:20 pm
FLO
-
TPA
1 stop3h 39m
American Airlines
Deal found 1/12$387
This American Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/281:51 pm
TPA
-
FLO
1 stop3h 59m
American Airlines
Mon 4/66:20 pm
FLO
-
TPA
1 stop6h 09m
American Airlines
Deal found 1/12$411
This American Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1811:41 am
TPA
-
FLO
1 stop4h 09m
American Airlines
Sun 4/194:16 pm
FLO
-
TPA
1 stop3h 57m
American Airlines
Deal found 1/13$431
This American Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/274:50 pm
TPA
-
FLO
1 stop5h 53m
American Airlines
Sat 1/316:15 am
FLO
-
TPA
1 stop6h 01m
American Airlines
Deal found 1/12$447
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/67:36 pm
TPA
-
FLO
1 stop4h 21m
American Airlines
Sun 3/86:20 pm
FLO
-
TPA
1 stop3h 39m
American Airlines
Deal found 1/14$455
This American Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/275:36 pm
MIA
-
FLO
1 stop5h 07m
American Airlines
Sat 1/316:15 am
FLO
-
MIA
1 stop4h 43m
American Airlines
Deal found 1/12$465
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:10 am
PBI
-
FLO
1 stop4h 35m
American Airlines
Mon 11/305:15 am
FLO
-
PBI
1 stop5h 49m
American Airlines
Deal found 1/14$471
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:46 pm
FLL
-
FLO
1 stop4h 17m
American Airlines
Sat 10/105:22 am
FLO
-
FLL
1 stop3h 43m
American Airlines
Deal found 1/14$481
This American Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/284:15 pm
FLL
-
FLO
1 stop6h 28m
American Airlines
Sun 2/16:15 am
FLO
-
FLL
1 stop4h 10m
American Airlines
Deal found 1/13$502
This American Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/56:26 pm
FLL
-
FLO
1 stop4h 17m
American Airlines
Mon 2/95:36 pm
FLO
-
FLL
1 stop6h 02m
American Airlines
Deal found 1/12$517
This American Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/46:56 pm
PBI
-
FLO
1 stop3h 47m
American Airlines
Fri 2/66:15 am
FLO
-
PBI
1 stop5h 19m
American Airlines
Deal found 1/13$768

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 14, 2026.
Use the filters below to find and compare flights from Florida to Florence that are best for you.

Fly from

Florida

Fly to

Florence

Route

Depart

Return

Price

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Wed 3/11

7:35 pm-11:57 pm

1 stop4h 22m

Florence

Wed 3/18

6:20 pm-9:59 pm

1 stop3h 39m

$387

OrlandoFlorence

MCO - FLO

MCOFLO

Orlando

Wed 2/11

1:05 pm-5:09 pm

1 stop4h 04m

Florence

Wed 2/18

5:58 pm-11:47 pm

1 stop5h 49m

$407

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Wed 3/25

11:53 am-5:50 pm

1 stop5h 57m

Florence

Wed 4/8

4:16 pm-9:58 pm

1 stop5h 42m

$407

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sat 3/28

1:51 pm-5:50 pm

1 stop3h 59m

Florence

Mon 4/6

6:20 pm-12:29 am

1 stop6h 09m

$411

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sat 4/18

11:41 am-3:50 pm

1 stop4h 09m

Florence

Sun 4/19

4:16 pm-8:13 pm

1 stop3h 57m

$431

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Tue 1/27

4:50 pm-10:43 pm

1 stop5h 53m

Florence

Sat 1/31

6:15 am-12:16 pm

1 stop6h 01m

$447

MiamiFlorence

MIA - FLO

MIAFLO

Miami

Tue 1/27

5:36 pm-10:43 pm

1 stop5h 07m

Florence

Sat 1/31

6:15 am-10:58 am

1 stop4h 43m

$465

Fort LauderdaleFlorence

FLL - FLO

FLLFLO

Fort Lauderdale

Thu 2/5

6:26 pm-10:43 pm

1 stop4h 17m

Florence

Mon 2/9

5:36 pm-11:38 pm

1 stop6h 02m

$517

Fort LauderdaleFlorence

FLL - FLO

FLLFLO

Fort Lauderdale

Wed 1/28

6:40 am-10:43 pm

2 stops16h 03m

Florence

Sun 2/1

6:15 am-6:11 pm

2 stops11h 56m

$639

West Palm BeachFlorence

PBI - FLO

PBIFLO

Palm Beach Intl

Wed 2/4

6:56 pm-10:43 pm

1 stop3h 47m

Florence

Fri 2/6

6:15 am-11:34 am

1 stop5h 19m

$768

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/12

Showing 1-10 of 31 results
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Best time to book a flight from Florida to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Florida with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida to Florence

What is the cheapest month to book a flight from Florida to Florence, South Carolina?

Currently, November is the cheapest month in which you can book a flight from Florida to Florence, South Carolina (average of $33). Flying from Florida to Florence, South Carolina in July is currently the most expensive (average of $74). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Florida to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Florida?

    Florence (FLO) is the airport you will fly into if you book a flight from Florida to Florence. It is only a 2.3 mi journey from Florence (FLO) to Florence’s city center.

  • How long is the flight from Florida to Florence, South Carolina?

    There are many flights that can get you from Florida to Florence, South Carolina in 4h 22m. Fly via American Airlines to get the fastest option. Florida and Florence, South Carolina are separated by a distance of 460 mi.

  • What are the most popular routes from Florida to Florence, South Carolina?

    When deciding which route to take from Florida to Florence, South Carolina consider Tampa - Florence, Fort Lauderdale - Florence or Miami - Florence as they are the most popular.

  • Can I find deals for flights from Florida to Florence that include hotel bookings?

    Yes. In addition to deals on Florida to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida to Florence.

  • Can I find deals for business class flights from Florida to Florence?

    Yes. Cheapflights offers flight deals from Florida to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florida to Florence, South Carolina?

    Currently, November is the cheapest month in which you can book a flight from Florida to Florence, South Carolina (average of $33). Flying from Florida to Florence, South Carolina in July is currently the most expensive (average of $74). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Florida to Florence

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Florida to Florence

Discover the top airline that operate flights from Florida to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 14, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$410Average$472FlexibilityNo cancel feeOn-time71%

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