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Florence

$318+ Cheap flights from Florida to Florence, SC (FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/26. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — FLO
Apr 1 — Apr 81
Wed 4/1
Wed 4/8
1 adult, Economy
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Cheap flight deals from Florida to Florence

Cheapest flights from Florida to Florence
Explore the most affordable flight options available from Florida to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 2, 2026.

This American Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/94:50 pm
TPA
-
FLO
1 stop7h 02m
American Airlines
Mon 5/114:16 pm
FLO
-
TPA
1 stop5h 42m
American Airlines
Deal found 2/27$431
This American Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:41 pm
RSW
-
FLO
1 stop4h 11m
American Airlines
Sun 5/105:20 am
FLO
-
RSW
1 stop4h 16m
American Airlines
Deal found 2/27$455
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:42 pm
MCO
-
FLO
1 stop5h 10m
American Airlines
Sun 4/194:16 pm
FLO
-
MCO
1 stop5h 43m
American Airlines
Deal found 2/28$455
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/175:37 pm
PBI
-
FLO
1 stop6h 15m
American Airlines
Sun 4/195:20 am
FLO
-
PBI
1 stop3h 41m
American Airlines
Deal found 2/28$455
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/307:33 pm
FLL
-
FLO
1 stop4h 24m
American Airlines
Mon 4/66:20 pm
FLO
-
FLL
1 stop6h 26m
American Airlines
Deal found 2/28$455
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/305:30 pm
MIA
-
FLO
1 stop6h 27m
American Airlines
Mon 4/66:20 pm
FLO
-
MIA
1 stop5h 23m
American Airlines
Deal found 2/28$499
This American Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/137:43 pm
PBI
-
FLO
1 stop4h 14m
American Airlines
Tue 3/176:15 am
FLO
-
PBI
1 stop4h 13m
American Airlines
Deal found 2/26$502
This American Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/197:42 pm
RSW
-
FLO
1 stop4h 15m
American Airlines
Mon 3/235:16 am
FLO
-
RSW
1 stop4h 14m
American Airlines
Deal found 3/1$537
This American Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/137:33 pm
FLL
-
FLO
1 stop4h 24m
American Airlines
Mon 3/165:16 am
FLO
-
FLL
1 stop5h 45m
American Airlines
Deal found 2/26$537
This American Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/147:52 pm
MCO
-
FLO
1 stop4h 05m
American Airlines
Wed 3/186:20 pm
FLO
-
MCO
1 stop3h 39m
American Airlines
Deal found 2/26$541
This American Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/145:30 pm
MIA
-
FLO
1 stop6h 27m
American Airlines
Wed 3/185:16 am
FLO
-
MIA
1 stop5h 57m
American Airlines
Deal found 2/26$607
This American Airlines deal was found by Cheapflights users on 2/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:30 am
FLL
-
FLO
2 stops11h 20m
American Airlines
Sun 3/155:16 am
FLO
-
FLL
2 stops12h 23m
American Airlines
Deal found 2/27$676

Find flight deals from Florida to Florence

Keep the following information in mind while searching for Florida to Florence flight deals. Data was last updated March 2, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$431
(American Airlines)

One-way from

$318
(American Airlines)
Provider with most accurate pricing for Orlando (ORL)-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Orlando (ORL)-Florence flights.
Search Deals
From Florida to Florence
Search Deals
One-way flight from Florida to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florida to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 2, 2026.
Use the filters below to find and compare flights from Florida to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

TampaFlorence

TPA - FLO

TPAFLO

Tampa

Sat 5/9

4:50 pm-11:52 pm

1 stop7h 02m

Florence

Mon 5/11

4:16 pm-9:58 pm

1 stop5h 42m

$431

Fort MyersFlorence

RSW - FLO

RSWFLO

Fort Myers SW Florida Intl

Thu 5/7

7:41 pm-11:52 pm

1 stop4h 11m

Florence

Sun 5/10

5:20 am-9:36 am

1 stop4h 16m

$455

West Palm BeachFlorence

PBI - FLO

PBIFLO

Palm Beach Intl

Fri 4/17

5:37 pm-11:52 pm

1 stop6h 15m

Florence

Sun 4/19

5:20 am-9:01 am

1 stop3h 41m

$455

Fort LauderdaleFlorence

FLL - FLO

FLLFLO

Fort Lauderdale

Fri 4/17

4:40 pm-11:52 pm

1 stop7h 12m

Florence

Sun 4/19

5:20 am-9:27 am

1 stop4h 07m

$455

MiamiFlorence

MIA - FLO

MIAFLO

Miami

Mon 3/30

5:30 pm-11:57 pm

1 stop6h 27m

Florence

Mon 4/6

6:20 pm-11:43 pm

1 stop5h 23m

$499

West Palm BeachFlorence

PBI - FLO

PBIFLO

Palm Beach Intl

Fri 3/13

7:43 pm-11:57 pm

1 stop4h 14m

Florence

Tue 3/17

6:15 am-10:28 am

1 stop4h 13m

$502

Fort MyersFlorence

RSW - FLO

RSWFLO

Fort Myers SW Florida Intl

Fri 3/20

7:42 pm-11:57 pm

1 stop4h 15m

Florence

Mon 3/23

5:16 am-11:26 am

1 stop6h 10m

$537

Fort MyersFlorence

RSW - FLO

RSWFLO

Fort Myers SW Florida Intl

Thu 3/19

7:42 pm-11:57 pm

1 stop4h 15m

Florence

Mon 3/23

5:16 am-9:30 am

1 stop4h 14m

$537

Fort LauderdaleFlorence

FLL - FLO

FLLFLO

Fort Lauderdale

Fri 3/13

7:33 pm-11:57 pm

1 stop4h 24m

Florence

Mon 3/16

5:16 am-11:01 am

1 stop5h 45m

$537

Fort LauderdaleFlorence

FLL - FLO

FLLFLO

Fort Lauderdale

Fri 3/13

7:33 pm-11:57 pm

1 stop4h 24m

Florence

Sun 3/15

6:20 pm-12:46 am

1 stop6h 26m

$537

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/26

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

Best time to book a flight from Florida to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Florida with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florida to Florence

What is the cheapest month to book a flight from Florida to Florence, South Carolina?

Currently, November is the cheapest month in which you can book a flight from Florida to Florence, South Carolina (average of $33). Flying from Florida to Florence, South Carolina in June is currently the most expensive (average of $67). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Florida to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Florida?

    Florence (FLO) is the airport you will fly into if you book a flight from Florida to Florence. It is only a 2.3 mi journey from Florence (FLO) to Florence’s city center.

  • How long is the flight from Florida to Florence, South Carolina?

    There are many flights that can get you from Florida to Florence, South Carolina in 7h 02m. Fly via American Airlines to get the fastest option. Florida and Florence, South Carolina are separated by a distance of 460 mi.

  • What are the most popular routes from Florida to Florence, South Carolina?

    When deciding which route to take from Florida to Florence, South Carolina consider Fort Myers SW Florida Intl - Florence, Fort Lauderdale - Florence or Tampa - Florence as they are the most popular.

  • Can I find deals for flights from Florida to Florence that include hotel bookings?

    Yes. In addition to deals on Florida to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florida to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florida to Florence.

  • Can I find deals for business class flights from Florida to Florence?

    Yes. Cheapflights offers flight deals from Florida to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florida to Florence, South Carolina?

    Currently, November is the cheapest month in which you can book a flight from Florida to Florence, South Carolina (average of $33). Flying from Florida to Florence, South Carolina in June is currently the most expensive (average of $67). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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