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$389+ Cheap flights from Denver to Florence, SC (DEN - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/28. Fares are subject to change and may not be available on all flights or dates of travel.
DEN — FLO
Jun 10 — Jun 171
Wed 6/10
Wed 6/17
1 adult, Economy
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Cheap flight deals from Denver to Florence

Cheapest flights from Denver to Florence
Explore the most affordable flight options available from Denver to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 11, 2026.

This American Airlines deal was found by Cheapflights users on 5/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/281:57 pm
DEN
-
FLO
1 stop6h 03m
American Airlines
Sun 5/315:05 am
FLO
-
DEN
1 stop6h 11m
American Airlines
Deal found 5/11$389
This American Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1011:59 pm
DEN
-
FLO
1 stop8h 22m
American Airlines
Mon 9/1411:20 am
FLO
-
DEN
1 stop5h 10m
American Airlines
Deal found 5/7$429
This American Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:38 am
DEN
-
FLO
1 stop5h 32m
American Airlines
Tue 6/92:35 pm
FLO
-
DEN
2 stops11h 20m
American Airlines
Deal found 5/8$434
This American Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:11 am
DEN
-
FLO
1 stop6h 29m
American Airlines
Wed 9/306:31 pm
FLO
-
DEN
1 stop5h 16m
American Airlines
Deal found 5/7$534
This American Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/184:27 pm
DEN
-
FLO
1 stop5h 46m
American Airlines
Wed 9/2311:20 am
FLO
-
DEN
2 stops10h 19m
American Airlines
Deal found 5/7$539
This American Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:30 am
DEN
-
FLO
1 stop5h 42m
American Airlines
Wed 9/95:31 am
FLO
-
DEN
1 stop5h 07m
American Airlines
Deal found 5/7$544
This American Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:38 am
DEN
-
FLO
1 stop5h 32m
American Airlines
Mon 6/82:35 pm
FLO
-
DEN
2 stops11h 20m
American Airlines
Deal found 5/10$546
This American Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:30 am
DEN
-
FLO
1 stop5h 42m
American Airlines
Thu 9/105:31 am
FLO
-
DEN
2 stops12h 02m
American Airlines
Deal found 5/7$549
This American Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/2611:59 pm
DEN
-
FLO
1 stop21h 38m
American Airlines
Sat 8/82:37 pm
FLO
-
DEN
1 stop7h 32m
American Airlines
Deal found 5/10$553

Find flight deals from Denver to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Denver (DEN) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$389
(American Airlines)
Provider with most accurate pricing for Denver Intl-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Denver Intl-Florence flights.
Search Deals
From Denver Intl to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Denver to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 11, 2026.
Use the filters below to find and compare flights from Denver to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Wed 6/3

1:57 pm-10:00 pm

1 stop6h 03m

Florence

Tue 6/9

5:05 am-9:16 am

1 stop6h 11m

$429

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Mon 6/1

6:55 am-10:00 pm

2 stops13h 05m

Florence

Sun 6/7

5:05 am-9:16 am

1 stop6h 11m

$534

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Sun 7/26

11:59 pm-11:37 pm

1 stop21h 38m

Florence

Sat 8/8

2:37 pm-8:09 pm

1 stop7h 32m

$553

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Wed 6/3

1:57 pm-10:00 pm

1 stop6h 03m

Florence

Mon 6/8

2:35 pm-11:55 pm

2 stops11h 20m

$581

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Fri 5/22

6:38 am-2:10 pm

1 stop5h 32m

Florence

Tue 5/26

2:35 pm-11:55 pm

2 stops11h 20m

$696

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Tue 6/23

10:38 am-10:00 pm

2 stops9h 22m

Florence

Mon 6/29

2:35 pm-8:13 pm

1 stop7h 38m

$696
Cheapest one-way

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Wed 6/3

7:22 am-10:00 pm

2 stops12h 38m

$593

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Tue 6/2

7:22 am-10:00 pm

2 stops12h 38m

$611

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Fri 6/5

7:05 am-10:00 pm

2 stops12h 55m

$659
Quickest one-way

DenverFlorence

DEN - FLO

DENFLO

Denver Intl

Mon 6/1

8:58 am-10:00 pm

2 stops11h 02m

$869

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/7

Sorted by cheapest first

Compare providers for flights from Denver to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Denver to Florence in May.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Denver-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Denver-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Denver-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Denver-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Denver-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Denver to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Denver with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Denver to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Denver to Florence, South Carolina?

    A quick flight from Denver to Florence, South Carolina can take about 6h 03m. American Airlines provides one of the quickest options available for as low as $429. Airlines will cover a distance of 1425 mi.

  • Can I find deals for flights from Denver to Florence that include hotel bookings?

    Yes. In addition to deals on Denver to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Denver to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Denver to Florence.

  • Can I find deals for business class flights from Denver to Florence?

    Yes. Cheapflights offers flight deals from Denver to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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