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$384+ Cheap flights from Cleveland to Florence, SC (CLE - FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
CLE — FLO
oct. 17 — oct. 241
vie. 10/17
vie. 10/24
1 adult, Economy
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Cheap flight deals from Cleveland to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Cleveland (CLE) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated septiembre 17, 2025.

Round-trip from

$421
(American Airlines)

One-way from

$384
(American Airlines)
From Cleveland Hopkins Intl to Florence
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One-way flight from Cleveland Hopkins Intl to Florence
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Find flight deals from Cleveland to Florence

Cheapest flights from Cleveland to Florence
Explore the most affordable flight options available from Cleveland to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/158:09 amCLE - FLO
1 stop6h 45mAmerican Airlines
mié. 10/226:14 amFLO - CLE
1 stop6h 44mAmerican Airlines
Deal found 9/15$421
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/301:24 pmCLE - FLO
1 stop3h 48mAmerican Airlines
sáb. 10/46:14 amFLO - CLE
1 stop6h 14mAmerican Airlines
Deal found 9/15$441
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/234:34 pmCLE - FLO
1 stop6h 42mAmerican Airlines
dom. 9/284:57 pmFLO - CLE
1 stop5h 24mAmerican Airlines
Deal found 9/15$535
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/237:06 amCLE - FLO
2 stops10h 06mAmerican Airlines
lun. 9/296:14 amFLO - CLE
1 stop4h 21mAmerican Airlines
Deal found 9/15$540
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/256:01 amCLE - FLO
1 stop4h 52mAmerican Airlines
dom. 9/285:14 amFLO - CLE
1 stop5h 58mAmerican Airlines
Deal found 9/15$559

Cheapflights Fare Finder

 
Customize your flight search to find flights from Cleveland to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 17, 2025.
Use the filters below to find and compare flights from Cleveland to Florence that are best for you.

Fly from

Cleveland

Fly to

Florence

Route

Depart

Return

Price

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

mié. 10/15

8:09 am-2:54 pm

1 stop6h 45m

Florence

mié. 10/22

6:14 am-12:58 pm

1 stop6h 44m

$421

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

mar. 9/30

1:24 pm-5:12 pm

1 stop3h 48m

Florence

sáb. 10/4

6:14 am-12:28 pm

1 stop6h 14m

$441

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

mié. 10/1

1:24 pm-5:12 pm

1 stop3h 48m

Florence

sáb. 10/4

6:14 am-12:28 pm

1 stop6h 14m

$511

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

jue. 10/2

8:03 pm-12:02 pm

2 stops15h 59m

Florence

sáb. 10/4

5:37 pm-12:27 pm

2 stops18h 50m

$518

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

jue. 10/2

10:10 am-4:32 pm

1 stop6h 22m

Florence

lun. 10/6

2:29 pm-6:46 pm

1 stop4h 17m

$519

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

mié. 10/15

6:45 pm-11:13 pm

1 stop4h 28m

$384

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Best time to book a flight from Cleveland to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Cleveland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Cleveland to Florence

What is the cheapest month to book a flight from Cleveland to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Cleveland to Florence, South Carolina (average of $366). Flying from Cleveland to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Cleveland to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Cleveland to Florence, South Carolina?

    For as low as $421, American Airlines can have you in Florence, South Carolina from Cleveland in 6h 45m. Cleveland and Florence, South Carolina are separated by a distance of 512 mi.

  • Can I find deals for flights from Cleveland to Florence that include hotel bookings?

    Yes. In addition to deals on Cleveland to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Cleveland to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Cleveland to Florence.

  • Can I find deals for business class flights from Cleveland to Florence?

    Yes. Cheapflights offers flight deals from Cleveland to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Cleveland to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Cleveland to Florence, South Carolina (average of $366). Flying from Cleveland to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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