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$367+ Cheap flights from Cleveland to Florence, SC (CLE - FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/10. Fares are subject to change and may not be available on all flights or dates of travel.
CLE — FLO
Aug 25 — Sep 11
Mon 8/25
Mon 9/1
1 adult, Economy
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Cheap flight deals from Cleveland to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Cleveland (CLE) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 20, 2025.

Round-trip from

$448
(American Airlines)

One-way from

$367
(American Airlines)
From Cleveland Hopkins Intl to Florence
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One-way flight from Cleveland Hopkins Intl to Florence
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Find flight deals from Cleveland to Florence

Cheapest flights from Cleveland to Florence
Explore the most affordable flight options available from Cleveland to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 20, 2025.

This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/158:09 amCLE - FLO
1 stop6h 45mAmerican Airlines
Mon 10/202:29 pmFLO - CLE
1 stop4h 17mAmerican Airlines
Deal found 8/18$448
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/168:15 amCLE - FLO
1 stop5h 49mAmerican Airlines
Sun 10/195:14 amFLO - CLE
1 stop6h 32mAmerican Airlines
Deal found 8/18$475
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/153:10 pmCLE - FLO
2 stops8h 03mAmerican Airlines
Sun 10/192:29 pmFLO - CLE
2 stops8h 02mAmerican Airlines
Deal found 8/18$480

Cheapflights Fare Finder

 
Customize your flight search to find flights from Cleveland to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 20, 2025.
Use the filters below to find and compare flights from Cleveland to Florence that are best for you.

Fly from

Cleveland

Fly to

Florence

Route

Depart

Return

Price

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Wed 10/15

6:45 pm-11:13 pm

1 stop4h 28m

Florence

Sun 10/19

5:14 am-11:46 am

1 stop6h 32m

$448

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Wed 10/15

8:09 am-2:54 pm

1 stop6h 45m

Florence

Mon 10/20

2:29 pm-6:46 pm

1 stop4h 17m

$448

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Thu 10/16

8:15 am-2:04 pm

1 stop5h 49m

Florence

Sun 10/19

5:14 am-11:46 am

1 stop6h 32m

$475

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Wed 9/10

9:00 am-10:53 am

2 stops25h 53m

$367

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Thu 9/11

12:18 pm-12:02 pm

2 stops23h 44m

$374

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Fri 9/12

12:18 pm-5:12 pm

2 stops28h 54m

$384

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Sat 9/6

4:34 pm-11:16 pm

1 stop6h 42m

$384

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Tue 9/9

4:34 pm-11:16 pm

1 stop6h 42m

$384

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Sun 9/7

12:03 pm-4:32 pm

1 stop4h 29m

$418

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Mon 9/8

4:34 pm-11:16 pm

1 stop6h 42m

$418

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/20

Best time to book a flight from Cleveland to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Cleveland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Cleveland to Florence

What is the cheapest month to book a flight from Cleveland to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Cleveland to Florence, South Carolina (average of $366). Flying from Cleveland to Florence, South Carolina in October is currently the most expensive (average of $487). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Cleveland to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Cleveland to Florence, South Carolina?

    For as low as $448, American Airlines can have you in Florence, South Carolina from Cleveland in 4h 28m. Cleveland and Florence, South Carolina are separated by a distance of 512 mi.

  • Can I find deals for flights from Cleveland to Florence that include hotel bookings?

    Yes. In addition to deals on Cleveland to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Cleveland to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Cleveland to Florence.

  • Can I find deals for business class flights from Cleveland to Florence?

    Yes. Cheapflights offers flight deals from Cleveland to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Cleveland to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Cleveland to Florence, South Carolina (average of $366). Flying from Cleveland to Florence, South Carolina in October is currently the most expensive (average of $487). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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