HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$449+ Cheap flights from Cleveland to Florence, SC (CLE - FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/12. Fares are subject to change and may not be available on all flights or dates of travel.
CLE — FLO
Aug 28 — Sep 41
Fri 8/28
Fri 9/4
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Cleveland to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Cleveland to Florence

Cheapest flights from Cleveland to Florence
Explore the most affordable flight options available from Cleveland to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2026.

This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/288:06 am
CLE
-
FLO
1 stop6h 04m
American Airlines
Tue 8/42:35 pm
FLO
-
CLE
1 stop4h 04m
American Airlines
Deal found 7/25$609
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/288:06 am
CLE
-
FLO
1 stop6h 04m
American Airlines
Mon 8/32:35 pm
FLO
-
CLE
1 stop4h 04m
American Airlines
Deal found 7/25$629
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/308:06 am
CLE
-
FLO
1 stop6h 04m
American Airlines
Mon 8/32:35 pm
FLO
-
CLE
1 stop4h 04m
American Airlines
Deal found 7/25$649
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:03 am
CLE
-
FLO
2 stops8h 07m
American Airlines
Tue 8/42:35 pm
FLO
-
CLE
2 stops9h 24m
American Airlines
Deal found 7/25$805
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/28:06 am
CLE
-
FLO
1 stop6h 04m
American Airlines
Tue 8/45:17 am
FLO
-
CLE
1 stop5h 55m
American Airlines
Deal found 7/25$931
This American Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/27:31 pm
CLE
-
FLO
1 stop4h 06m
American Airlines
Mon 8/32:35 pm
FLO
-
CLE
1 stop4h 04m
American Airlines
Deal found 7/25$965

Find flight deals from Cleveland to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Cleveland (CLE) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$629
(American Airlines)

One-way from

$449
(American Airlines)
Provider with most accurate pricing for Cleveland Hopkins Intl-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Cleveland Hopkins Intl-Florence flights.
Search Deals
From Cleveland Hopkins Intl to Florence
Search Deals
One-way flight from Cleveland Hopkins Intl to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Cleveland to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2026.
Use the filters below to find and compare flights from Cleveland to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Wed 8/12

9:30 am-2:56 pm

1 stop5h 26m

Florence

Sun 8/16

5:05 am-11:39 am

1 stop6h 34m

$629

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Thu 8/13

2:30 pm-10:59 pm

2 stops8h 29m

Florence

Sun 8/16

2:37 pm-6:30 pm

1 stop3h 53m

$777
Cheapest one-way
Quickest one-way

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Thu 8/13

9:30 am-2:56 pm

1 stop5h 26m

$483

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/27

Sorted by cheapest first

Compare providers for flights from Cleveland to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Cleveland to Florence in July.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Cleveland-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Cleveland-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Cleveland-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Cleveland-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Cleveland-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Cleveland to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Cleveland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Cleveland to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Cleveland to Florence, South Carolina?

    For as low as $629, American Airlines can have you in Florence, South Carolina from Cleveland in 5h 26m. Cleveland and Florence, South Carolina are separated by a distance of 512 mi.

  • Can I find deals for flights from Cleveland to Florence that include hotel bookings?

    Yes. In addition to deals on Cleveland to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Cleveland to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Cleveland to Florence.

  • Can I find deals for business class flights from Cleveland to Florence?

    Yes. Cheapflights offers flight deals from Cleveland to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Cleveland to Florence

See prices for flight routes from nearby airports that may be better suited for you.
Detroit to Charlotte flights
Akron to Myrtle Beach flights
Detroit to Myrtle Beach flights
Cleveland to Charlotte flights
Detroit to Savannah flights
Detroit to Charleston flights
Pittsburgh to Myrtle Beach flights
Cleveland to Myrtle Beach flights
Pittsburgh to Charleston flights
Cincinnati to Charlotte flights
Detroit to Greenville flights
Akron to Charleston flights
Cincinnati to Myrtle Beach flights
Pittsburgh to Charlotte flights
Akron to Savannah flights
Cleveland to Savannah flights
Columbus to Myrtle Beach flights
Cleveland to Charleston flights
Columbus to Charlotte flights
Pittsburgh to Hilton Head Island flights
Cleveland to Columbia flights
Cincinnati to Charleston flights
Cincinnati to Savannah flights
Dayton to Charlotte flights
Dayton to Myrtle Beach flights
Akron to Charlotte flights
Columbus to Savannah flights
Pittsburgh to Savannah flights
Columbus to Charleston flights
Dayton to Savannah flights
Cincinnati to Hilton Head Island flights
Columbus to Columbia flights
Cleveland to Hilton Head Island flights
Columbus to Hilton Head Island flights
Detroit to Columbia flights
Columbus to Greenville flights
Cleveland to Greenville flights
Akron to Hilton Head Island flights
Detroit to Hilton Head Island flights
Dayton to Charleston flights
Rickenbacker to Myrtle Beach flights
Erie to Charlotte flights
Pittsburgh to Columbia flights
Pittsburgh to Greenville flights
Huntington to Myrtle Beach flights
Columbus to Augusta flights
Detroit to Augusta flights
Dayton to Hilton Head Island flights
Cincinnati to Columbia flights
Akron to Greenville flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.