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$481+ Cheap flights from Cleveland to Florence, SC (CLE - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/2. Fares are subject to change and may not be available on all flights or dates of travel.
CLE — FLO
Dec 19 — Dec 261
Fri 12/19
Fri 12/26
1 adult, Economy
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Find flight deals from Cleveland to Florence

Cheapest flights from Cleveland to Florence
Explore the most affordable flight options available from Cleveland to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 19, 2025.

This American Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/21:14 pmCLE - FLO
1 stop3h 55mAmerican Airlines
Sat 12/611:16 amFLO - CLE
1 stop3h 39mAmerican Airlines
Deal found 11/17$481
This American Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/296:30 amCLE - FLO
1 stop4h 15mAmerican Airlines
Mon 12/16:33 pmFLO - CLE
1 stop6h 10mAmerican Airlines
Deal found 11/18$555
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/46:01 amCLE - FLO
2 stops12h 04mAmerican Airlines
Mon 12/86:15 amFLO - CLE
2 stops12h 45mAmerican Airlines
Deal found 11/19$557

Cheap flight deals from Cleveland to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Cleveland (CLE) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 19, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$481
(American Airlines)
Provider with most accurate pricing for Cleveland Hopkins Intl-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Cleveland Hopkins Intl-Florence flights.
Search Deals
From Cleveland Hopkins Intl to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Cleveland to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 19, 2025.
Use the filters below to find and compare flights from Cleveland to Florence that are best for you.

Fly from

Cleveland

Fly to

Florence

Route

Depart

Return

Price

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Tue 12/2

1:14 pm-5:09 pm

1 stop3h 55m

Florence

Sat 12/6

11:16 am-2:55 pm

1 stop3h 39m

$481

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Sat 1/3

6:36 pm-12:15 am

1 stop5h 39m

Florence

Wed 1/7

6:15 am-12:35 pm

1 stop6h 20m

$491

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Sat 11/29

6:30 am-10:45 am

1 stop4h 15m

Florence

Mon 12/1

6:33 pm-12:43 am

1 stop6h 10m

$555

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Thu 12/4

6:01 am-6:05 pm

2 stops12h 04m

Florence

Mon 12/8

6:15 am-7:00 pm

2 stops12h 45m

$557

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/17

Compare providers for flights from Cleveland to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Cleveland to Florence in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Cleveland-Florence, South Carolina flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Cleveland-Florence, South Carolina flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Cleveland-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Cleveland-Florence, South Carolina flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Cleveland-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Cleveland to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Cleveland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Cleveland to Florence

What is the cheapest month to book a flight from Cleveland to Florence, South Carolina?

Currently, September is the cheapest month in which you can book a flight from Cleveland to Florence, South Carolina (average of $47). Flying from Cleveland to Florence, South Carolina in November is currently the most expensive (average of $97). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florence

Get insights into the airlines that provide service to Florence. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florence. Reviews last updated November 19, 2025.
Read reviews from past customers who have flown American Airlines from Cleveland to Florence. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,046 reviews

Crew

8.0

Boarding

7.5

Comfort

7.2

Overall

7.2

Entertainment

6.9

Food

6.4

Reviews

1 / 20
8.0
Excellent

Monica,Nov 2025

JAC - DFW

At least there was an option of entertainment on this flight.
American Airlines
7.2
Good
11,046 reviews
American Airlines
7.2
Good
11,046 reviews

Crew

8.0

Boarding

7.5

Comfort

7.2

Overall

7.2

Entertainment

6.9

Food

6.4

Reviews

1 / 20
8.0
Excellent

Monica,Nov 2025

JAC - DFW

At least there was an option of entertainment on this flight.

Related info for your journey

Find useful and relevant information for your journey from Cleveland to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Cleveland to Florence, South Carolina?

    For as low as $481, American Airlines can have you in Florence, South Carolina from Cleveland in 3h 55m. Cleveland and Florence, South Carolina are separated by a distance of 512 mi.

  • Can I find deals for flights from Cleveland to Florence that include hotel bookings?

    Yes. In addition to deals on Cleveland to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Cleveland to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Cleveland to Florence.

  • Can I find deals for business class flights from Cleveland to Florence?

    Yes. Cheapflights offers flight deals from Cleveland to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Cleveland to Florence, South Carolina?

    Currently, September is the cheapest month in which you can book a flight from Cleveland to Florence, South Carolina (average of $47). Flying from Cleveland to Florence, South Carolina in November is currently the most expensive (average of $97). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Top airline flying from Cleveland to Florence

Discover the top airline that operate flights from Cleveland to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 19, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$325Average$479FlexibilityNo cancel feeOn-time71%

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