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$242+ Cheap flights from San Francisco to Florence, SC (SFO - FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/7. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — FLO
Jan 24 — Jan 311
Sat 1/24
Sat 1/31
1 adult, Economy
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Cheap flight deals from San Francisco to Florence

Cheapest flights from San Francisco to Florence
Explore the most affordable flight options available from San Francisco to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 25, 2025.

This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/261:31 pmSFO - FLO
1 stop7h 44mAmerican Airlines
Wed 12/3112:51 pmFLO - SFO
1 stop8h 01mAmerican Airlines
Deal found 12/22$679
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/261:31 pmSFO - FLO
1 stop7h 44mAmerican Airlines
Thu 1/16:30 pmFLO - SFO
1 stop7h 37mAmerican Airlines
Deal found 12/22$686
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:00 amSFO - FLO
1 stop8h 05mAmerican Airlines
Sun 1/46:30 pmFLO - SFO
1 stop7h 37mAmerican Airlines
Deal found 12/22$718
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/277:00 amSFO - FLO
1 stop8h 05mAmerican Airlines
Sun 1/46:30 pmFLO - SFO
1 stop7h 37mAmerican Airlines
Deal found 12/22$727
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:00 amSFO - FLO
1 stop8h 05mAmerican Airlines
Sat 1/31:07 pmFLO - SFO
1 stop7h 45mAmerican Airlines
Deal found 12/22$779
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:00 amSFO - FLO
1 stop8h 05mAmerican Airlines
Wed 12/316:30 pmFLO - SFO
1 stop7h 37mAmerican Airlines
Deal found 12/22$782
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/277:00 amSFO - FLO
1 stop8h 05mAmerican Airlines
Sat 1/31:07 pmFLO - SFO
1 stop10h 44mAmerican Airlines
Deal found 12/22$788
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/257:00 amSFO - FLO
1 stop8h 05mAmerican Airlines
Thu 1/16:30 pmFLO - SFO
1 stop7h 37mAmerican Airlines
Deal found 12/22$789

Find flight deals from San Francisco to Florence

Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 25, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars
Provider with most accurate pricing for San Francisco-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for San Francisco-Florence flights.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Francisco to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 25, 2025.
Use the filters below to find and compare flights from San Francisco to Florence that are best for you.

Fly from

San Francisco

Fly to

Florence

Route

Depart

Return

Price

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Wed 1/7

7:00 am-5:09 pm

1 stop7h 09m

$242

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Sat 1/3

12:22 am-12:42 pm

1 stop9h 20m

$420

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/24

Compare providers for flights from San Francisco to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Florence in December.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on San Francisco-Florence, South Carolina flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on San Francisco-Florence, South Carolina flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from San Francisco-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on San Francisco-Florence, South Carolina flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from San Francisco to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Florence

What is the cheapest month to book a flight from San Francisco to Florence, South Carolina?

Currently, May is the cheapest month in which you can book a flight from San Francisco to Florence, South Carolina (average of $148). Flying from San Francisco to Florence, South Carolina in March is currently the most expensive (average of $220). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florence

Get insights into the airlines that provide service to Florence. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florence. Reviews last updated December 25, 2025.
Get a feel of what it's like to fly with American Airlines from San Francisco to Florence by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,056 reviews

Crew

8.0

Boarding

7.5

Overall

7.2

Food

6.4

Entertainment

6.9

Comfort

7.2

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit
American Airlines
7.2
Good
11,056 reviews
American Airlines
7.2
Good
11,056 reviews

Crew

8.0

Boarding

7.5

Overall

7.2

Food

6.4

Entertainment

6.9

Comfort

7.2

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What is the cheapest airline to fly from San Francisco to Florence, South Carolina round-trip?

    Flying on American Airlines is currently your cheapest option to Florence, South Carolina, with prices starting at $400.

  • Can I find deals for flights from San Francisco to Florence that include hotel bookings?

    Yes. In addition to deals on San Francisco to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Florence.

  • Can I find deals for business class flights from San Francisco to Florence?

    Yes. Cheapflights offers flight deals from San Francisco to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to Florence, South Carolina?

    Currently, May is the cheapest month in which you can book a flight from San Francisco to Florence, South Carolina (average of $148). Flying from San Francisco to Florence, South Carolina in March is currently the most expensive (average of $220). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Top airline flying from San Francisco to Florence

Discover the top airline that operate flights from San Francisco to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 25, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$400Average$512FlexibilityNo cancel feeOn-time71%

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