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$537+ Cheap flights from San Francisco to Florence, SC (SFO - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — FLO
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from San Francisco to Florence

Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 16, 2025.

Round-trip from

$537
(American Airlines)
From San Francisco to Florence
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Find flight deals from San Francisco to Florence

Cheapest flights from San Francisco to Florence
Explore the most affordable flight options available from San Francisco to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/137:15 amSFO - FLO
1 stop7h 52mAmerican Airlines
Mon 11/175:35 pmFLO - SFO
1 stop7h 33mAmerican Airlines
Deal found 9/16$537
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1212:27 amSFO - FLO
1 stop7h 18mAmerican Airlines
Sun 11/165:15 amFLO - SFO
1 stop10h 15mAmerican Airlines
Deal found 9/16$643

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Francisco to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from San Francisco to Florence that are best for you.

Fly from

San Francisco

Fly to

Florence

Route

Depart

Return

Price

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Thu 11/13

1:31 pm-12:03 am

1 stop7h 32m

Florence

Sun 11/16

5:15 am-12:30 pm

1 stop10h 15m

$537

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Fri 11/14

7:10 am-5:09 pm

1 stop6h 59m

Florence

Mon 11/17

5:35 pm-10:08 pm

1 stop7h 33m

$537

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Fri 11/14

7:10 am-5:09 pm

1 stop6h 59m

Florence

Sun 11/16

5:15 am-12:30 pm

1 stop10h 15m

$537

San FranciscoFlorence

SFO - FLO

SFOFLO

San Francisco

Thu 11/13

7:15 am-6:07 pm

1 stop7h 52m

Florence

Mon 11/17

5:35 pm-10:08 pm

1 stop7h 33m

$537

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Best time to book a flight from San Francisco to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Florence

What is the cheapest month to book a flight from San Francisco to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from San Francisco to Florence, South Carolina (average of $366). Flying from San Francisco to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florence

Get insights into the airlines that provide service to Florence. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florence. Reviews last updated September 16, 2025.
Get a feel of what it's like to fly with American Airlines from San Francisco to Florence by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Comfort

7.2

Food

6.4

Crew

8.0

Boarding

7.5

Overall

7.2

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Comfort

7.2

Food

6.4

Crew

8.0

Boarding

7.5

Overall

7.2

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Jeremy,Sep 2025

SAN - PHL

Terrible. Bad customer service and unacceptable delay on the tarmac

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from San Francisco to Florence, South Carolina?

    Airlines like American Airlines fly from San Francisco to Florence, South Carolina in about 7h 32m. The time it takes to get you to your destination can typically vary by up to . The distance between San Francisco and Florence, South Carolina is about 2377 mi.

  • What is the cheapest airline to fly from San Francisco to Florence, South Carolina round-trip?

    Flying on American Airlines is currently your cheapest option to Florence, South Carolina, with prices starting at $400.

  • Can I find deals for flights from San Francisco to Florence that include hotel bookings?

    Yes. In addition to deals on San Francisco to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Francisco to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Florence.

  • Can I find deals for business class flights from San Francisco to Florence?

    Yes. Cheapflights offers flight deals from San Francisco to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Francisco to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from San Francisco to Florence, South Carolina (average of $366). Flying from San Francisco to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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Top airline flying from San Francisco to Florence

Discover the top airline that operate flights from San Francisco to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$400Average$512FlexibilityNo cancel feeOn-time71%

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