HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$480+ Cheap flights from Cleveland to Florence, SC (CLE - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/24. Fares are subject to change and may not be available on all flights or dates of travel.
CLE — FLO
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Cleveland to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Cleveland to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Cleveland (CLE) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$545
(American Airlines)
From Cleveland Hopkins Intl to Florence
Search Deals

Find flight deals from Cleveland to Florence

Cheapest flights from Cleveland to Florence
Explore the most affordable flight options available from Cleveland to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/241:24 pmCLE - FLO
1 stop3h 48mAmerican Airlines
Sun 9/285:14 amFLO - CLE
1 stop5h 58mAmerican Airlines
Deal found 9/9$480
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/268:00 pmCLE - FLO
2 stops14h 46mAmerican Airlines
Sat 11/19:00 amFLO - CLE
2 stops11h 06mAmerican Airlines
Deal found 9/8$498
This American Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/265:00 amCLE - FLO
1 stop5h 46mAmerican Airlines
Sun 11/25:15 amFLO - CLE
1 stop4h 30mAmerican Airlines
Deal found 9/8$545

Cheapflights Fare Finder

 
Customize your flight search to find flights from Cleveland to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Cleveland to Florence that are best for you.

Fly from

Cleveland

Fly to

Florence

Route

Depart

Return

Price

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Wed 9/24

1:24 pm-5:12 pm

1 stop3h 48m

Florence

Sun 9/28

5:14 am-11:12 am

1 stop5h 58m

$480

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Sun 10/26

8:00 pm-10:46 am

2 stops14h 46m

Florence

Sat 11/1

9:00 am-8:06 pm

2 stops11h 06m

$498

ClevelandFlorence

CLE - FLO

CLEFLO

Cleveland Hopkins Intl

Sun 10/26

5:00 am-10:46 am

1 stop5h 46m

Florence

Sun 11/2

5:15 am-9:45 am

1 stop4h 30m

$545

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Best time to book a flight from Cleveland to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Cleveland with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Cleveland to Florence

What is the cheapest month to book a flight from Cleveland to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Cleveland to Florence, South Carolina (average of $366). Flying from Cleveland to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Cleveland to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Cleveland to Florence, South Carolina?

    For as low as $480, American Airlines can have you in Florence, South Carolina from Cleveland in 3h 48m. Cleveland and Florence, South Carolina are separated by a distance of 512 mi.

  • Can I find deals for flights from Cleveland to Florence that include hotel bookings?

    Yes. In addition to deals on Cleveland to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Cleveland to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Cleveland to Florence.

  • Can I find deals for business class flights from Cleveland to Florence?

    Yes. Cheapflights offers flight deals from Cleveland to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Cleveland to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Cleveland to Florence, South Carolina (average of $366). Flying from Cleveland to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Cleveland to Florence

See prices for flight routes from nearby airports that may be better suited for you.
Cleveland to Charlotte flights
Detroit to Charlotte flights
Detroit to Savannah flights
Detroit to Charleston flights
Detroit to Myrtle Beach flights
Pittsburgh to Myrtle Beach flights
Akron to Myrtle Beach flights
Cincinnati to Charlotte flights
Columbus to Charleston flights
Akron to Charlotte flights
Pittsburgh to Charlotte flights
Cincinnati to Savannah flights
Cleveland to Charleston flights
Cleveland to Myrtle Beach flights
Columbus to Charlotte flights
Cleveland to Savannah flights
Akron to Savannah flights
Pittsburgh to Charleston flights
Detroit to Greenville flights
Columbus to Savannah flights
Dayton to Myrtle Beach flights
Akron to Charleston flights
Columbus to Myrtle Beach flights
Cleveland to Greenville flights
Cincinnati to Myrtle Beach flights
Cincinnati to Charleston flights
Columbus to Columbia flights
Cleveland to Columbia flights
Columbus to Hilton Head Island flights
Dayton to Charlotte flights
Cincinnati to Hilton Head Island flights
Pittsburgh to Savannah flights
Detroit to Columbia flights
Dayton to Savannah flights
Dayton to Charleston flights
Cleveland to Hilton Head Island flights
Cincinnati to Greenville flights
Pittsburgh to Hilton Head Island flights
Pittsburgh to Columbia flights
Cincinnati to Columbia flights
Akron to Columbia flights
Akron to Greenville flights
Pittsburgh to Greenville flights
Detroit to Augusta flights
Dayton to Hilton Head Island flights
Detroit to Hilton Head Island flights
Dayton to Columbia flights
Erie to Charlotte flights
Dayton to Greenville flights
Akron to Hilton Head Island flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.