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$76+ Cheap flights from Des Moines (DSM) to Durham, NC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/4. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — RDU
Apr 27 — May 41
Mon 4/27
Mon 5/4
1 adult, Economy
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Cheap flight deals from Des Moines to Durham

Cheapest flights from Des Moines to Durham
Explore the most affordable flight options available from Des Moines to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 28, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:45 am
DSM
-
RDU
1 stop8h 23m
Multiple Airlines
Tue 5/1912:26 pm
RDU
-
DSM
1 stop26h 05m
Multiple Airlines
Deal found 3/24$240
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2010:23 am
DSM
-
RDU
1 stop29h 33m
Multiple Airlines
Wed 4/224:00 pm
RDU
-
DSM
2 stops22h 46m
Multiple Airlines
Deal found 3/27$257
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/317:30 am
DSM
-
RDU
1 stop26h 26m
Multiple Airlines
Thu 6/47:05 am
RDU
-
DSM
1 stop16h 53m
Multiple Airlines
Deal found 3/24$258
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/227:11 am
DSM
-
RDU
1 stop8h 44m
American Airlines
Mon 4/276:28 pm
RDU
-
DSM
1 stop4h 50m
American Airlines
Deal found 3/24$260
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/293:57 pm
DSM
-
RDU
1 stop21h 15m
Multiple Airlines
Tue 6/23:07 pm
RDU
-
DSM
2 stops23h 24m
Multiple Airlines
Deal found 3/24$263
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/203:21 pm
DSM
-
RDU
2 stops7h 23m
United Airlines
Wed 4/225:25 pm
RDU
-
DSM
1 stop6h 52m
United Airlines
Deal found 3/26$265
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/267:00 am
DSM
-
RDU
1 stop6h 43m
Multiple Airlines
Sun 5/39:49 pm
RDU
-
DSM
1 stop22h 49m
Multiple Airlines
Deal found 3/27$268
This Kiwi.com deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/112:16 pm
DSM
-
RDU
1 stop20h 15m
Multiple Airlines
Mon 5/189:03 pm
RDU
-
DSM
2 stops41h 28m
Multiple Airlines
Deal found 3/26$272
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:40 am
DSM
-
RDU
2 stops8h 40m
Southwest
Wed 4/291:45 pm
RDU
-
DSM
2 stops9h 25m
Southwest
Deal found 3/26$282
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/213:04 pm
DSM
-
RDU
1 stop6h 23m
United Airlines
Fri 4/2410:07 am
RDU
-
DSM
1 stop5h 12m
United Airlines
Deal found 3/26$283

Find flight deals from Des Moines to Durham

Keep the following information in mind while searching for Des Moines to Durham flight deals. Data was last updated March 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$240
(Kiwi.com)

One-way from

$76
(Expedia)

Popular in

December

Cheapest in

September

Average price

$383
Provider with most accurate pricing for Des Moines-Raleigh-Durham flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Raleigh-Durham flights.
Search Deals
From Des Moines to Durham
Search Deals
One-way flight from Des Moines to Durham
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($23 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2026.
Use the filters below to find and compare flights from Des Moines to Durham that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Mon 4/20

3:21 pm-11:44 pm

2 stops7h 23m

Raleigh-Durham

Wed 4/22

5:25 pm-11:17 pm

1 stop6h 52m

$265

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Mon 6/1

6:41 pm-12:16 am

1 stop4h 35m

Raleigh-Durham

Thu 6/4

6:00 am-12:24 pm

1 stop7h 24m

$283

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Sat 5/9

4:25 pm-11:40 pm

1 stop6h 15m

Raleigh-Durham

Sat 5/16

6:00 am-10:16 am

1 stop5h 16m

$283

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Tue 4/21

8:04 am-4:20 pm

2 stops7h 16m

Raleigh-Durham

Fri 4/24

10:07 am-2:19 pm

1 stop5h 12m

$288

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Mon 5/11

4:20 pm-9:45 pm

1 stop4h 25m

Raleigh-Durham

Mon 5/18

4:25 pm-11:05 pm

2 stops7h 40m

$312

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Wed 4/22

8:20 am-3:48 pm

1 stop6h 28m

Raleigh-Durham

Sun 4/26

6:15 am-10:44 am

1 stop5h 29m

$322

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Thu 5/7

7:45 am-5:08 pm

1 stop8h 23m

Raleigh-Durham

Thu 5/14

6:03 pm-10:57 pm

2 stops29h 54m

$332

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Sat 5/9

5:35 am-3:15 pm

2 stops8h 40m

Raleigh-Durham

Sat 5/16

8:00 am-8:55 pm

2 stops13h 55m

$354

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Fri 4/24

3:21 pm-9:23 pm

1 stop5h 02m

Raleigh-Durham

Sat 4/25

5:25 pm-11:17 pm

1 stop6h 52m

$367
Quickest round-trip

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Tue 9/22

6:20 am-11:42 am

1 stop4h 22m

Raleigh-Durham

Sun 9/27

5:45 am-9:19 am

1 stop4h 34m

$384

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/23

Showing 1-10 of 18 resultsSorted by cheapest first
1
2

Best time to book a flight from Des Moines to Durham

Have a flexible travel schedule? Discover the best time to fly to Durham from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Durham

What is the cheapest month to book a flight from Des Moines to Durham?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Durham (average of $184). Flying from Des Moines to Durham in December is currently the most expensive (average of $346). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Des Moines to Durham?

Reviews of airlines servicing Durham

Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated March 28, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Des Moines to Durham by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,333 reviews

Overall

8.0

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Food

7.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Southwest
8.0
Very good
4,333 reviews
Southwest
8.0
Very good
4,333 reviews

Overall

8.0

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Food

7.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
Delta
7.9
Good
8,356 reviews
Southwest
8.0
Very good
4,333 reviews

Overall

8.0

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Food

7.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
United Airlines
7.4
Good
9,499 reviews
Southwest
8.0
Very good
4,333 reviews

Overall

8.0

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Food

7.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.
American Airlines
7.1
Good
11,520 reviews
Southwest
8.0
Very good
4,333 reviews

Overall

8.0

Entertainment

7.5

Boarding

8.1

Comfort

8.0

Food

7.0

Crew

8.6

Reviews

1 / 20
2.0
Mediocre

Dominic,Mar 2026

MCO - SMF

I had to try and sleep on the floor of the Austin airport. I spent 12 hours there. The airline policies were so poor, that a near violent argument broke out between the people in front of me and the flight attendants - making for a super stressful situation at 30,000 feet. Garbage airline choice by Kayak Garbage idea to book a flight with a layover. Next time I will pay for a quality booking myself, and somehow force the company to reimburse it.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Durham?

    For a flight from Des Moines to Durham, you will be flying from Des Moines. Des Moines (DSM) is just 3.6 mi from the center of the city. Des Moines is the only Des Moines airport and it handles 0 outbound flights to Durham per day. 4 airlines have flights to Durham from Des Moines on a regular basis.

  • How long is the flight from Des Moines to Durham?

    Departing from Des Moines to Durham will take you 4h 25m. The distance between Des Moines and Durham is about 890 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Des Moines to Durham one-way?

    For one-way options, check prices for Southwest. According to our data, you can fly for as low as $135. Users have also found prices from $135 and $148 on American Airlines and United Airlines, respectively.

  • Can I find deals for flights from Des Moines to Durham that include hotel bookings?

    Yes. In addition to deals on Des Moines to Durham flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Durham?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Durham.

  • Can I find deals for business class flights from Des Moines to Durham?

    Yes. Cheapflights offers flight deals from Des Moines to Durham by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Durham?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Durham (average of $184). Flying from Des Moines to Durham in December is currently the most expensive (average of $346). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 4 airlines flying from Des Moines to Durham

Discover the top 4 airlines that operate flights from Des Moines to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$216Average$426FlexibilityNo cancel feeOn-time63%
DeltaCheapest$236Average$390FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$327FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$276Average$386FlexibilityNo cancel feeOn-time69%

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