$102+ Cheap flights from Des Moines (DSM) to Durham, NC
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/31. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — RDU
Sep 2 — Sep 91
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Durham with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Best
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Cheapest flights from Des Moines to DurhamExplore the most affordable flight options available from Des Moines to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 3, 2026.
Explore the most affordable flight options available from Des Moines to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:05 pm
DSM
- RDU
2 stops22h 10m
Multiple Airlines
Sat 8/228:09 pm
RDU
- DSM
1 stop24h 45m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$252
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/18:00 am
DSM
- RDU
1 stop24h 10m
Multiple Airlines
Wed 11/43:54 pm
RDU
- DSM
2 stops24h 31m
Multiple Airlines
Deal found 8/2![Multiple Airlines logo]()
$257
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/253:04 pm
DSM
- RDU
1 stop17h 04m
Multiple Airlines
Sun 9/272:54 pm
RDU
- DSM
1 stop6h 03m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/282:53 pm
DSM
- RDU
1 stop17h 59m
Multiple Airlines
Sun 8/309:43 am
RDU
- DSM
1 stop11h 11m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/301:55 pm
DSM
- RDU
2 stops33h 04m
Multiple Airlines
Thu 9/39:43 am
RDU
- DSM
1 stop11h 14m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:10 am
DSM
- RDU
2 stops15h 19m
Multiple Airlines
Sun 10/49:35 pm
RDU
- DSM
1 stop13h 35m
Multiple Airlines
Deal found 8/1![Multiple Airlines logo]()
$272
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/183:04 pm
DSM
- RDU
1 stop17h 04m
Multiple Airlines
Sun 9/202:54 pm
RDU
- DSM
1 stop6h 03m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$286
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/61:58 pm
DSM
- RDU
2 stops40h 38m
Multiple Airlines
Sun 9/132:54 pm
RDU
- DSM
1 stop6h 03m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$300
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:53 pm
DSM
- RDU
1 stop17h 59m
Multiple Airlines
Tue 8/258:16 pm
RDU
- DSM
2 stops37h 22m
Multiple Airlines
Deal found 8/2![Multiple Airlines logo]()
$304
Best flights from Des Moines to DurhamDiscover carefully curated flight deals from Des Moines to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 3, 2026.
Discover carefully curated flight deals from Des Moines to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 3, 2026.
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:35 pm
DSM
- RDU
1 stop4h 37m
Delta
Sat 9/196:20 am
RDU
- DSM
1 stop5h 26m
Delta
Deal found 7/29![Delta logo]()
$325
This Southwest deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/143:50 pm
DSM
- RDU
1 stop4h 40m
Southwest
Mon 9/216:45 pm
RDU
- DSM
1 stop4h 30m
Southwest
Deal found 7/31![Southwest logo]()
$351
This United Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:24 am
DSM
- RDU
2 stops6h 43m
United Airlines
Mon 9/146:25 am
RDU
- DSM
1 stop6h 51m
United Airlines
Deal found 8/2![United Airlines logo]()
$356
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/24:01 pm
DSM
- RDU
1 stop6h 56m
Delta
Fri 11/64:44 pm
RDU
- DSM
1 stop6h 49m
Delta
Deal found 7/30![Delta logo]()
$355
This Southwest deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:40 am
DSM
- RDU
2 stops7h 20m
Southwest
Mon 9/144:20 pm
RDU
- DSM
2 stops6h 55m
Southwest
Deal found 8/2![Southwest logo]()
$361
This United Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:00 am
DSM
- RDU
1 stop4h 49m
United Airlines
Fri 10/24:27 pm
RDU
- DSM
1 stop8h 21m
United Airlines
Deal found 8/1![United Airlines logo]()
$368
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/172:54 pm
DSM
- RDU
1 stop7h 31m
Delta
Sat 8/226:00 am
RDU
- DSM
1 stop5h 18m
Delta
Deal found 7/31![Delta logo]()
$371
This Southwest deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:25 am
DSM
- RDU
1 stop4h 15m
Southwest
Sun 11/86:35 am
RDU
- DSM
2 stops7h 35m
Southwest
Deal found 8/1![Southwest logo]()
$389
Last-minute flights from Des Moines to DurhamDiscover last-minute flight deals from Des Moines to Durham. Data last updated August 3, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Durham. Data last updated August 3, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:07 pm
DSM
- RDU
1 stop20h 59m
Multiple Airlines
Thu 8/209:43 am
RDU
- DSM
1 stop11h 11m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/133:41 pm
DSM
- RDU
1 stop16h 07m
Multiple Airlines
Sun 8/168:06 pm
RDU
- DSM
2 stops28h 08m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:05 pm
DSM
- RDU
2 stops22h 10m
Multiple Airlines
Sat 8/228:09 pm
RDU
- DSM
1 stop24h 45m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$252
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:05 pm
DSM
- RDU
2 stops22h 10m
Multiple Airlines
Thu 8/209:43 am
RDU
- DSM
1 stop11h 11m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$312
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/201:55 pm
DSM
- RDU
1 stop17h 58m
Multiple Airlines
Sun 8/239:43 am
RDU
- DSM
1 stop11h 11m
Multiple Airlines
Deal found 8/1![Multiple Airlines logo]()
$314
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/212:53 pm
DSM
- RDU
1 stop17h 59m
Multiple Airlines
Tue 8/258:16 pm
RDU
- DSM
2 stops37h 22m
Multiple Airlines
Deal found 8/2![Multiple Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/282:53 pm
DSM
- RDU
1 stop17h 59m
Multiple Airlines
Sun 8/309:43 am
RDU
- DSM
1 stop11h 11m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/301:55 pm
DSM
- RDU
2 stops33h 04m
Multiple Airlines
Thu 9/39:43 am
RDU
- DSM
1 stop11h 14m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$269
One-way flights from Des Moines to DurhamSearch for one-way flight options from Des Moines to Durham. Find affordable one-way fares based on user searches. Data last updated August 3, 2026.
Search for one-way flight options from Des Moines to Durham. Find affordable one-way fares based on user searches. Data last updated August 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/315:28 pm
DSM
- RDU
1 stop23h 47m
Multiple Airlines
Deal found 8/2![Multiple Airlines logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/301:55 pm
DSM
- RDU
2 stops33h 04m
Multiple Airlines
Deal found 8/2![Multiple Airlines logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/231:55 pm
DSM
- RDU
2 stops33h 04m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$147
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/1512:26 pm
DSM
- RDU
2 stops18h 45m
Multiple Airlines
Deal found 8/2![Multiple Airlines logo]()
$155
This Trip.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/142:19 pm
DSM
- RDU
1 stop20h 12m
Frontier
Deal found 7/31![Frontier logo]()
$161
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:10 am
DSM
- RDU
1 stop4h 25m
Southwest
Deal found 8/3![Southwest logo]()
$163
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/201:55 pm
DSM
- RDU
1 stop20h 34m
Multiple Airlines
Deal found 8/1![Multiple Airlines logo]()
$167
Find flight deals from Des Moines to Durham
Keep the following information in mind while searching for Des Moines to Durham flight deals. Data was last updated August 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $252 (Kiwi.com) |
One-way from | $102 (Kiwi.com) |
Popular in | August |
Cheapest in | September |
Average price | $486 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 3, 2026.
Use the filters below to find and compare flights from Des Moines to Durham that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Sat 9/12
5:35 pm-11:12 pm
1 stop4h 37m
Raleigh-Durham
Sat 9/19
6:20 am-10:46 am
1 stop5h 26m
$325
Quickest round-trip
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Mon 9/14
3:50 pm-9:30 pm
1 stop4h 40m
Raleigh-Durham
Mon 9/21
6:45 pm-10:15 pm
1 stop4h 30m
$351
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Mon 11/2
4:01 pm-11:57 pm
1 stop6h 56m
Raleigh-Durham
Fri 11/6
4:44 pm-10:33 pm
1 stop6h 49m
$355
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Thu 9/10
6:24 am-2:07 pm
2 stops6h 43m
Raleigh-Durham
Mon 9/14
6:25 am-12:16 pm
1 stop6h 51m
$356
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Thu 9/10
5:40 am-2:00 pm
2 stops7h 20m
Raleigh-Durham
Mon 9/14
4:20 pm-10:15 pm
2 stops6h 55m
$361
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Thu 10/1
8:00 am-1:49 pm
1 stop4h 49m
Raleigh-Durham
Fri 10/2
4:27 pm-11:48 pm
1 stop8h 21m
$368
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Mon 8/17
2:54 pm-11:25 pm
1 stop7h 31m
Raleigh-Durham
Sat 8/22
6:00 am-10:18 am
1 stop5h 18m
$371
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Thu 11/5
5:25 am-10:40 am
1 stop4h 15m
Raleigh-Durham
Sun 11/8
6:35 am-1:10 pm
2 stops7h 35m
$389
Cheapest one-way
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Sat 8/15
12:26 pm-8:11 am
2 stops18h 45m
$155
Quickest one-way
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Wed 9/2
6:10 am-11:35 am
1 stop4h 25m
$163
Showing 1-10 of 19 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Durham
Have a flexible travel schedule? Discover the best time to fly to Durham from Des Moines with our price prediction graph.
DSM-RDU
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Durham
DSM-DU8
DSM-RDU
How much does it cost to fly round-trip from Des Moines to Durham?
Airfare is below average for this route at the moment.
Des Moines to Durham flights typically cost between $356 and $617 in August.The cheapest round-trip price found within the last 5 days was $252 on Multiple Airlines (Aug 17-Aug 22).
Reviews of airlines servicing Durham
Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated August 3, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Des Moines to Durham by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Des Moines and Durham flights
Browse other Des Moines and Durham flight options. Last updated on August 3, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on August 3, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Des Moines to Durham flights
Consider these flights traveling from Des Moines to Durham.
Top 4 airlines flying from Des Moines to Durham
Discover the top 4 airlines that operate flights from Des Moines to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$236 | Average$405 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$350 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$284 | Average$386 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$309 | Average$416 | FlexibilityNo cancel fee | On-time63% |