$118+ Cheap flights from Des Moines (DSM) to Durham, NC
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/13. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — RDU
Jul 10 — Jul 171
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Des Moines to Durham with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Durham
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to DurhamExplore the most affordable flight options available from Des Moines to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 10, 2026.
Explore the most affordable flight options available from Des Moines to Durham. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:07 pm
DSM
- RDU
1 stop22h 08m
Multiple Airlines
Sun 8/166:35 pm
RDU
- DSM
1 stop5h 44m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$235
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/99:33 am
DSM
- RDU
1 stop22h 27m
Multiple Airlines
Sun 8/166:35 pm
RDU
- DSM
1 stop5h 44m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$256
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/64:40 pm
DSM
- RDU
2 stops17h 35m
Multiple Airlines
Thu 7/167:05 am
RDU
- DSM
1 stop17h 02m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/64:40 pm
DSM
- RDU
1 stop23h 29m
Multiple Airlines
Sun 7/127:05 am
RDU
- DSM
1 stop15h 53m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:07 pm
DSM
- RDU
1 stop22h 08m
Multiple Airlines
Thu 8/206:15 am
RDU
- DSM
2 stops14h 39m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$266
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/168:03 am
DSM
- RDU
1 stop4h 03m
American Airlines
Mon 9/211:56 pm
RDU
- DSM
1 stop6h 55m
American Airlines
Deal found 6/8![American Airlines logo]()
$273
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:40 am
DSM
- RDU
1 stop4h 35m
Southwest
Tue 10/68:10 am
RDU
- DSM
1 stop4h 15m
Southwest
Deal found 6/8![Southwest logo]()
$274
Best flights from Des Moines to DurhamDiscover carefully curated flight deals from Des Moines to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 10, 2026.
Discover carefully curated flight deals from Des Moines to Durham that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 10, 2026.
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:40 am
DSM
- RDU
1 stop4h 35m
Southwest
Tue 10/68:10 am
RDU
- DSM
1 stop4h 15m
Southwest
Deal found 6/8![Southwest logo]()
$274
This Delta deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:00 pm
DSM
- RDU
1 stop6h 42m
Delta
Wed 7/156:00 am
RDU
- DSM
1 stop5h 13m
Delta
Deal found 6/6![Delta logo]()
$356
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:00 am
DSM
- RDU
1 stop7h 07m
United Airlines
Wed 8/268:06 am
RDU
- DSM
1 stop7h 10m
United Airlines
Deal found 6/9![United Airlines logo]()
$370
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/203:50 pm
DSM
- RDU
1 stop4h 35m
Southwest
Tue 8/256:30 am
RDU
- DSM
1 stop8h 25m
Southwest
Deal found 6/5![Southwest logo]()
$326
This Delta deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:34 pm
DSM
- RDU
1 stop4h 54m
Delta
Wed 7/155:33 am
RDU
- DSM
1 stop5h 12m
Delta
Deal found 6/6![Delta logo]()
$356
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/143:24 pm
DSM
- RDU
1 stop5h 13m
United Airlines
Wed 7/155:12 pm
RDU
- DSM
1 stop6h 44m
United Airlines
Deal found 6/8![United Airlines logo]()
$386
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/35:34 pm
DSM
- RDU
1 stop4h 54m
Delta
Mon 7/67:30 am
RDU
- DSM
1 stop7h 05m
Delta
Deal found 6/8![Delta logo]()
$383
This Southwest deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1912:10 pm
DSM
- RDU
1 stop4h 55m
Southwest
Thu 9/246:45 pm
RDU
- DSM
1 stop4h 25m
Southwest
Deal found 6/6![Southwest logo]()
$394
This Delta deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:00 am
DSM
- RDU
1 stop4h 57m
Delta
Mon 8/175:32 am
RDU
- DSM
1 stop5h 11m
Delta
Deal found 6/7![Delta logo]()
$394
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/15:20 am
DSM
- RDU
2 stops6h 50m
Southwest
Fri 7/31:40 pm
RDU
- DSM
2 stops9h 40m
Southwest
Deal found 6/5![Southwest logo]()
$400
Last-minute flights from Des Moines to DurhamDiscover last-minute flight deals from Des Moines to Durham. Data last updated June 10, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Durham. Data last updated June 10, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/53:59 pm
DSM
- RDU
2 stops31h 05m
Multiple Airlines
Sun 7/127:05 am
RDU
- DSM
1 stop15h 53m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/54:57 pm
DSM
- RDU
1 stop14h 51m
Multiple Airlines
Thu 7/167:05 am
RDU
- DSM
1 stop17h 02m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$300
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/64:40 pm
DSM
- RDU
1 stop23h 29m
Multiple Airlines
Thu 7/167:05 am
RDU
- DSM
1 stop17h 02m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$256
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/64:40 pm
DSM
- RDU
1 stop23h 29m
Multiple Airlines
Sun 7/127:05 am
RDU
- DSM
1 stop15h 53m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$265
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/73:24 pm
DSM
- RDU
1 stop5h 13m
United Airlines
Tue 7/145:12 pm
RDU
- DSM
1 stop5h 10m
United Airlines
Deal found 6/9![United Airlines logo]()
$306
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/93:42 pm
DSM
- RDU
1 stop16h 06m
Multiple Airlines
Sun 7/127:05 am
RDU
- DSM
1 stop15h 53m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/93:42 pm
DSM
- RDU
1 stop16h 06m
Multiple Airlines
Thu 7/167:05 am
RDU
- DSM
1 stop17h 02m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$301
One-way flights from Des Moines to DurhamSearch for one-way flight options from Des Moines to Durham. Find affordable one-way fares based on user searches. Data last updated June 10, 2026.
Search for one-way flight options from Des Moines to Durham. Find affordable one-way fares based on user searches. Data last updated June 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/134:40 pm
DSM
- RDU
1 stop23h 29m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$118
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2110:05 am
DSM
- RDU
1 stop22h 03m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$125
This Booking.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/152:19 pm
DSM
- RDU
1 stop20h 12m
Frontier
Deal found 6/5![Frontier logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:08 pm
DSM
- RDU
2 stops29h 56m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$136
This Booking.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/142:19 pm
DSM
- RDU
1 stop20h 12m
Frontier
Deal found 6/9![Frontier logo]()
$147
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/155:30 am
DSM
- RDU
1 stop4h 05m
Southwest
Deal found 6/9![Southwest logo]()
$149
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:07 pm
DSM
- RDU
2 stops28h 57m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$157
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/155:20 am
DSM
- RDU
2 stops6h 50m
Southwest
Deal found 6/5![Southwest logo]()
$161
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/215:40 am
DSM
- RDU
2 stops9h 30m
Southwest
Deal found 6/7![Southwest logo]()
$164
Find flight deals from Des Moines to Durham
Keep the following information in mind while searching for Des Moines to Durham flight deals. Data was last updated June 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $235 (Kiwi.com) |
One-way from | $118 (Kiwi.com) |
Popular in | April |
Cheapest in | September |
Average price | $325 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Durham that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 10, 2026.
Use the filters below to find and compare flights from Des Moines to Durham that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Sat 10/3
5:40 am-11:15 am
1 stop4h 35m
Raleigh-Durham
Tue 10/6
8:10 am-11:25 am
1 stop4h 15m
$274
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Thu 8/20
3:50 pm-9:25 pm
1 stop4h 35m
Raleigh-Durham
Tue 8/25
6:30 am-1:55 pm
1 stop8h 25m
$326
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Fri 7/3
5:00 pm-12:42 am
1 stop6h 42m
Raleigh-Durham
Wed 7/15
6:00 am-10:13 am
1 stop5h 13m
$356
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Sat 7/4
5:34 pm-11:28 pm
1 stop4h 54m
Raleigh-Durham
Wed 7/15
5:33 am-9:45 am
1 stop5h 12m
$356
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Mon 8/24
6:00 am-2:07 pm
1 stop7h 07m
Raleigh-Durham
Wed 8/26
8:06 am-2:16 pm
1 stop7h 10m
$370
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Fri 7/3
5:34 pm-11:28 pm
1 stop4h 54m
Raleigh-Durham
Mon 7/6
7:30 am-1:35 pm
1 stop7h 05m
$383
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Tue 7/14
3:24 pm-9:37 pm
1 stop5h 13m
Raleigh-Durham
Wed 7/15
5:12 pm-10:56 pm
1 stop6h 44m
$386
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Sat 9/19
12:10 pm-6:05 pm
1 stop4h 55m
Raleigh-Durham
Thu 9/24
6:45 pm-10:10 pm
1 stop4h 25m
$394
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Wed 8/12
6:00 am-11:57 am
1 stop4h 57m
Raleigh-Durham
Mon 8/17
5:32 am-9:43 am
1 stop5h 11m
$394
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Wed 7/1
5:20 am-1:10 pm
2 stops6h 50m
Raleigh-Durham
Fri 7/3
1:40 pm-10:20 pm
2 stops9h 40m
$400
Showing 1-10 of 19 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Durham
Have a flexible travel schedule? Discover the best time to fly to Durham from Des Moines with our price prediction graph.
DSM-RDU
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Durham
DSM-DU8
DSM-RDU
How much does it cost to fly round-trip from Des Moines to Durham?
Reviews of airlines servicing Durham
Get insights into the airlines that provide service to Durham. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Durham. Reviews last updated June 10, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Des Moines to Durham by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Boarding
8.1
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Overall
7.9
Boarding
8.1
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Overall
7.9
Boarding
8.1
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Overall
7.9
Boarding
8.1
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Overall
7.9
Boarding
8.1
Comfort
8.0
Food
7.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Durham. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Des Moines
Popular flights
Top destinations
Alternative routes for Des Moines to Durham
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Durham by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to Durham by cabin class
Find flights from Des Moines to Durham, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Durham flights
Browse other Des Moines and Durham flight options. Last updated on June 10, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on June 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Des Moines to Durham flights
Consider these flights traveling from Des Moines to Durham.
Top 4 airlines flying from Des Moines to Durham
Discover the top 4 airlines that operate flights from Des Moines to Durham. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$216 | Average$406 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$236 | Average$405 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$337 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$284 | Average$351 | FlexibilityNo cancel fee | On-time69% |