$329+ Cheap flights from Syracuse to Des Moines (SYR - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/25. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — DSM
Sep 16 — Sep 231
Round-trip
1 adult, Economy
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Find cheap flights from Syracuse to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Syracuse to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Syracuse to Des MoinesExplore the most affordable flight options available from Syracuse to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 17, 2026.
Explore the most affordable flight options available from Syracuse to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 17, 2026.
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:20 am -
1 stop4h 18m
Mon 9/285:35 pm -
1 stop4h 23m
Deal found 8/12![Delta logo]()
$329
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:40 pm -
1 stop7h 01m
Fri 9/185:56 pm -
1 stop5h 11m
Deal found 8/12![American Airlines logo]()
$330
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/295:13 am -
2 stops9h 46m
Tue 10/66:00 am -
1 stop7h 10m
Deal found 8/15![American Airlines logo]()
$334
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:00 am -
2 stops9h 15m
Tue 10/66:00 am -
2 stops7h 19m
Deal found 8/15![United Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:52 pm -
1 stop4h 52m
Sun 8/306:10 am -
1 stop4h 38m
Deal found 8/13![American Airlines logo]()
$379
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/197:52 pm -
1 stop4h 52m
Sun 9/66:10 am -
1 stop4h 38m
Deal found 8/14![American Airlines logo]()
$385
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:00 am -
2 stops7h 20m
Sun 8/306:00 am -
2 stops7h 14m
Deal found 8/13![United Airlines logo]()
$389
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:00 am -
2 stops7h 20m
Sun 9/65:45 am -
1 stop8h 22m
Deal found 8/14![United Airlines logo]()
$390
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:40 pm -
1 stop7h 01m
Mon 9/282:29 pm -
2 stops8h 18m
Deal found 8/13![American Airlines logo]()
$404
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:50 pm -
1 stop6h 45m
Sat 10/171:26 pm -
1 stop6h 31m
Deal found 8/14![United Airlines logo]()
$409
Best flights from Syracuse to Des MoinesDiscover carefully curated flight deals from Syracuse to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 17, 2026.
Discover carefully curated flight deals from Syracuse to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 17, 2026.
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/175:20 pm -
1 stop4h 30m
Wed 12/26:00 am -
1 stop5h 59m
Deal found 8/16![Delta logo]()
$329
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:10 am -
1 stop5h 21m
Sat 10/101:26 pm -
1 stop6h 31m
Deal found 8/15![United Airlines logo]()
$329
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:40 pm -
1 stop7h 01m
Sun 9/276:00 am -
1 stop8h 00m
Deal found 8/14![American Airlines logo]()
$329
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:00 am -
1 stop5h 26m
Sun 11/81:27 pm -
1 stop8h 26m
Deal found 8/14![United Airlines logo]()
$379
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:00 am -
2 stops7h 20m
Sun 8/306:00 am -
2 stops7h 14m
Deal found 8/13![United Airlines logo]()
$389
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:00 am -
2 stops7h 20m
Sat 9/51:18 pm -
2 stops9h 28m
Deal found 8/16![United Airlines logo]()
$389
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:50 pm -
1 stop6h 45m
Sat 10/171:26 pm -
1 stop6h 31m
Deal found 8/15![United Airlines logo]()
$409
Last-minute flights from Syracuse to Des MoinesDiscover last-minute flight deals from Syracuse to Des Moines. Data last updated August 17, 2026 and is based on user searches.
Discover last-minute flight deals from Syracuse to Des Moines. Data last updated August 17, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/197:52 pm -
1 stop4h 52m
Sun 9/66:10 am -
1 stop4h 38m
Deal found 8/14![American Airlines logo]()
$385
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:00 am -
2 stops7h 20m
Sun 9/65:45 am -
1 stop8h 22m
Deal found 8/14![United Airlines logo]()
$390
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/277:52 pm -
1 stop4h 52m
Sun 8/306:10 am -
1 stop4h 38m
Deal found 8/13![American Airlines logo]()
$379
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:00 am -
2 stops7h 20m
Sun 8/306:00 am -
2 stops7h 14m
Deal found 8/13![United Airlines logo]()
$389
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:40 pm -
1 stop7h 01m
Fri 9/185:56 pm -
1 stop5h 11m
Deal found 8/12![American Airlines logo]()
$330
This Kiwi.com deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/119:24 am -
1 stop12h 17m
Fri 9/188:30 pm -
2 stops45h 19m
Deal found 8/12![Multiple Airlines logo]()
$449
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:20 am -
1 stop4h 18m
Mon 9/285:35 pm -
1 stop4h 23m
Deal found 8/12![Delta logo]()
$329
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:40 pm -
1 stop7h 01m
Mon 9/282:29 pm -
2 stops8h 18m
Deal found 8/12![American Airlines logo]()
$404
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/295:13 am -
2 stops9h 46m
Tue 10/66:00 am -
1 stop7h 10m
Deal found 8/15![American Airlines logo]()
$334
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:00 am -
2 stops9h 15m
Tue 10/66:00 am -
2 stops7h 19m
Deal found 8/15![United Airlines logo]()
$339
One-way flights from Syracuse to Des MoinesSearch for one-way flight options from Syracuse to Des Moines. Find affordable one-way fares based on user searches. Data last updated August 17, 2026.
Search for one-way flight options from Syracuse to Des Moines. Find affordable one-way fares based on user searches. Data last updated August 17, 2026.
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:06 pm -
1 stop5h 20m
Deal found 8/15![American Airlines logo]()
$478
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/92:55 pm -
3 stops20h 36m
Deal found 8/15![United Airlines logo]()
$1,062
Find flight deals from Syracuse to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Syracuse (SYR) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $329 (Delta) |
Popular in | April |
Cheapest in | December |
Average price | $478 |
Cheapflights Fare Finder
Customize your flight search to find flights from Syracuse to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 17, 2026.
Use the filters below to find and compare flights from Syracuse to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Tue 11/17
5:20 pm-8:50 pm
1 stop4h 30m
Des Moines
Wed 12/2
6:00 am-12:59 pm
1 stop5h 59m
$329
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Sat 10/3
6:10 am-10:31 am
1 stop5h 21m
Des Moines
Sat 10/10
1:26 pm-8:57 pm
1 stop6h 31m
$329
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Fri 9/25
5:40 pm-11:41 pm
1 stop7h 01m
Des Moines
Sun 9/27
6:00 am-3:00 pm
1 stop8h 00m
$329
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Thu 11/5
6:00 am-10:26 am
1 stop5h 26m
Des Moines
Sun 11/8
1:27 pm-10:53 pm
1 stop8h 26m
$379
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Thu 8/27
6:00 am-12:20 pm
2 stops7h 20m
Des Moines
Sun 8/30
6:00 am-2:14 pm
2 stops7h 14m
$389
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Tue 9/1
6:00 am-12:20 pm
2 stops7h 20m
Des Moines
Sat 9/5
1:18 pm-11:46 pm
2 stops9h 28m
$389
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Wed 10/14
5:50 pm-11:35 pm
1 stop6h 45m
Des Moines
Sat 10/17
1:26 pm-8:57 pm
1 stop6h 31m
$409
Cheapest one-way
Quickest one-way
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Wed 9/9
1:06 pm-5:26 pm
1 stop5h 20m
$478
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Wed 9/9
2:55 pm-10:31 am
3 stops20h 36m
$1,062
Sorted by cheapest first
Compare providers for flights from Syracuse to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Syracuse to Des Moines in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Syracuse-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Syracuse-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Syracuse-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Syracuse-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Syracuse-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Syracuse to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Syracuse with our price prediction graph.
SYR-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Syracuse to Des Moines
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated August 17, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Syracuse to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Boarding
8.1
Comfort
7.8
Overall
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Food
7.2
Boarding
8.1
Comfort
7.8
Overall
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Food
7.2
Boarding
8.1
Comfort
7.8
Overall
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Food
7.2
Boarding
8.1
Comfort
7.8
Overall
7.8
Crew
8.5
Entertainment
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Related info for your journey
Find useful and relevant information for your journey from Syracuse to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
Ames
Johnston
Boone
Norwalk
West Des Moines
Ankeny
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Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 17, 2026.
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Syracuse and Des Moines flights
Browse other Syracuse and Des Moines flight options. Last updated on August 17, 2026.
Other flights from Syracuse
Browse through other flights departing from Syracuse. Flights are based on user searches made on Cheapflights and were last updated on August 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Syracuse to Des Moines
Discover the top 3 airlines that operate flights from Syracuse to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$458 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$305 | Average$366 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$305 | Average$393 | FlexibilityNo cancel fee | On-time71% |