$188+ Cheap flights from Syracuse to Des Moines (SYR - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/25. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — DSM
Jul 24 — Jul 311
Round-trip
1 adult, Economy
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Find cheap flights from Syracuse to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Syracuse to Des Moines
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Cheapest flights from Syracuse to Des MoinesExplore the most affordable flight options available from Syracuse to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 24, 2026.
Explore the most affordable flight options available from Syracuse to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/68:16 pm
SYR
- DSM
1 stop27h 58m
Allegiant Air
Sat 8/1512:26 pm
DSM
- SYR
1 stop20h 22m
Allegiant Air
Deal found 6/22![Allegiant Air logo]()
$272
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/97:26 pm
SYR
- DSM
1 stop22h 51m
Allegiant Air
Sat 8/1512:26 pm
DSM
- SYR
1 stop20h 22m
Allegiant Air
Deal found 6/22![Allegiant Air logo]()
$303
This Delta deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/612:16 pm
SYR
- DSM
1 stop7h 59m
Delta
Mon 8/106:00 am
DSM
- SYR
1 stop6h 01m
Delta
Deal found 6/22![Delta logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/108:41 pm
SYR
- DSM
1 stop16h 22m
Allegiant Air
Sat 8/1512:26 pm
DSM
- SYR
1 stop20h 22m
Allegiant Air
Deal found 6/22![Allegiant Air logo]()
$329
This American Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/58:12 pm
SYR
- DSM
1 stop5h 13m
American Airlines
Wed 8/196:00 am
DSM
- SYR
1 stop4h 50m
American Airlines
Deal found 6/23![American Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/158:19 pm
SYR
- DSM
1 stop4h 42m
American Airlines
Sat 7/183:22 pm
DSM
- SYR
1 stop5h 19m
American Airlines
Deal found 6/19![American Airlines logo]()
$344
This Delta deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:21 am
SYR
- DSM
1 stop4h 24m
Delta
Sun 7/128:45 am
DSM
- SYR
1 stop7h 42m
Delta
Deal found 6/23![Delta logo]()
$369
This United Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/76:15 am
SYR
- DSM
1 stop5h 02m
United Airlines
Sat 7/1111:23 am
DSM
- SYR
2 stops11h 36m
United Airlines
Deal found 6/22![United Airlines logo]()
$374
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/78:41 pm
SYR
- DSM
1 stop14h 42m
Allegiant Air
Sat 8/1512:26 pm
DSM
- SYR
1 stop20h 22m
Allegiant Air
Deal found 6/22![Allegiant Air logo]()
$376
This Delta deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/86:20 am
SYR
- DSM
1 stop4h 10m
Delta
Sat 8/156:06 pm
DSM
- SYR
1 stop4h 02m
Delta
Deal found 6/22![Delta logo]()
$379
This American Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/88:12 pm
SYR
- DSM
1 stop5h 23m
American Airlines
Tue 8/181:55 pm
DSM
- SYR
2 stops9h 00m
American Airlines
Deal found 6/19![American Airlines logo]()
$380
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/88:12 pm
SYR
- DSM
1 stop5h 23m
American Airlines
Mon 8/171:09 pm
DSM
- SYR
1 stop7h 58m
American Airlines
Deal found 6/20![American Airlines logo]()
$389
Best flights from Syracuse to Des MoinesDiscover carefully curated flight deals from Syracuse to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 24, 2026.
Discover carefully curated flight deals from Syracuse to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 24, 2026.
This Delta deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/86:20 am
SYR
- DSM
1 stop4h 10m
Delta
Tue 8/186:00 am
DSM
- SYR
1 stop6h 01m
Delta
Deal found 6/22![Delta logo]()
$319
This American Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/88:12 pm
SYR
- DSM
1 stop5h 23m
American Airlines
Tue 8/181:55 pm
DSM
- SYR
2 stops9h 00m
American Airlines
Deal found 6/19![American Airlines logo]()
$380
This United Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:10 am
SYR
- DSM
1 stop5h 25m
United Airlines
Sat 10/311:05 pm
DSM
- SYR
1 stop6h 56m
United Airlines
Deal found 6/23![United Airlines logo]()
$399
This Delta deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:21 am
SYR
- DSM
1 stop4h 24m
Delta
Sun 7/128:45 am
DSM
- SYR
1 stop7h 42m
Delta
Deal found 6/23![Delta logo]()
$369
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/88:12 pm
SYR
- DSM
1 stop5h 23m
American Airlines
Mon 8/171:09 pm
DSM
- SYR
1 stop7h 58m
American Airlines
Deal found 6/20![American Airlines logo]()
$389
Last-minute flights from Syracuse to Des MoinesDiscover last-minute flight deals from Syracuse to Des Moines. Data last updated June 24, 2026 and is based on user searches.
Discover last-minute flight deals from Syracuse to Des Moines. Data last updated June 24, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/266:11 am
SYR
- DSM
1 stop4h 33m
Delta
Sun 6/285:34 pm
DSM
- SYR
1 stop4h 23m
Delta
Deal found 6/20![Delta logo]()
$469
This American Airlines deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/2611:15 am
SYR
- DSM
2 stops8h 24m
American Airlines
Sun 6/285:00 am
DSM
- SYR
1 stop4h 27m
American Airlines
Deal found 6/20![American Airlines logo]()
$474
This United Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/76:15 am
SYR
- DSM
1 stop5h 02m
United Airlines
Sat 7/1111:23 am
DSM
- SYR
2 stops11h 36m
United Airlines
Deal found 6/22![United Airlines logo]()
$374
This American Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/77:34 pm
SYR
- DSM
1 stop5h 35m
American Airlines
Sat 7/116:02 am
DSM
- SYR
1 stop7h 32m
American Airlines
Deal found 6/22![American Airlines logo]()
$422
This Delta deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/86:21 am
SYR
- DSM
1 stop4h 24m
Delta
Sun 7/128:45 am
DSM
- SYR
1 stop7h 42m
Delta
Deal found 6/23![Delta logo]()
$369
This Kiwi.com deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/83:53 pm
SYR
- DSM
2 stops32h 14m
Multiple Airlines
Sun 7/126:00 am
DSM
- SYR
1 stop6h 46m
Multiple Airlines
Deal found 6/23![Multiple Airlines logo]()
$429
This American Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/158:19 pm
SYR
- DSM
1 stop4h 42m
American Airlines
Sat 7/183:22 pm
DSM
- SYR
1 stop5h 19m
American Airlines
Deal found 6/19![American Airlines logo]()
$344
This Delta deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:21 am
SYR
- DSM
1 stop4h 24m
Delta
Sun 7/198:45 am
DSM
- SYR
1 stop7h 42m
Delta
Deal found 6/21![Delta logo]()
$508
One-way flights from Syracuse to Des MoinesSearch for one-way flight options from Syracuse to Des Moines. Find affordable one-way fares based on user searches. Data last updated June 24, 2026.
Search for one-way flight options from Syracuse to Des Moines. Find affordable one-way fares based on user searches. Data last updated June 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/255:23 pm
SYR
- DSM
1 stop17h 44m
Allegiant Air
Deal found 6/24![Allegiant Air logo]()
$188
This Kiwi.com deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/254:49 pm
SYR
- DSM
2 stops30h 58m
Multiple Airlines
Deal found 6/24![Multiple Airlines logo]()
$194
This Kiwi.com deal was found by Cheapflights users on 6/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/107:31 pm
SYR
- DSM
1 stop21h 38m
Allegiant Air
Deal found 6/20![Allegiant Air logo]()
$196
This Kiwi.com deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/294:57 pm
SYR
- DSM
2 stops29h 30m
Multiple Airlines
Deal found 6/24![Multiple Airlines logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/78:41 pm
SYR
- DSM
1 stop14h 42m
Allegiant Air
Deal found 6/19![Allegiant Air logo]()
$222
This American Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/77:52 pm
SYR
- DSM
1 stop4h 52m
American Airlines
Deal found 6/21![American Airlines logo]()
$304
This Delta deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/73:46 pm
SYR
- DSM
1 stop7h 43m
Delta
Deal found 6/23![Delta logo]()
$379
Find flight deals from Syracuse to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Syracuse (SYR) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $272 (Kiwi.com) |
One-way from | $196 (Kiwi.com) |
Popular in | August |
Cheapest in | September |
Average price | $423 |
Cheapflights Fare Finder
Customize your flight search to find flights from Syracuse to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 24, 2026.
Use the filters below to find and compare flights from Syracuse to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
SyracuseDes Moines
SYR - DSM
SYRDSM
Syracuse Hancock Intl
Sat 8/8
6:20 am-9:30 am
1 stop4h 10m
Des Moines
Tue 8/18
6:00 am-1:01 pm
1 stop6h 01m
$319
SyracuseDes Moines
SYR - DSM
SYRDSM
Syracuse Hancock Intl
Wed 7/8
6:21 am-9:45 am
1 stop4h 24m
Des Moines
Sun 7/12
8:45 am-5:27 pm
1 stop7h 42m
$369
SyracuseDes Moines
SYR - DSM
SYRDSM
Syracuse Hancock Intl
Sat 8/8
8:12 pm-12:35 am
1 stop5h 23m
Des Moines
Tue 8/18
1:55 pm-11:55 pm
2 stops9h 00m
$380
SyracuseDes Moines
SYR - DSM
SYRDSM
Syracuse Hancock Intl
Sat 8/8
8:12 pm-12:35 am
1 stop5h 23m
Des Moines
Mon 8/17
1:09 pm-10:07 pm
1 stop7h 58m
$389
SyracuseDes Moines
SYR - DSM
SYRDSM
Syracuse Hancock Intl
Tue 10/27
6:10 am-10:35 am
1 stop5h 25m
Des Moines
Sat 10/31
1:05 pm-9:01 pm
1 stop6h 56m
$399
Cheapest one-way
SyracuseDes Moines
SYR - DSM
SYRDSM
Syracuse Hancock Intl
Wed 7/29
4:57 pm-9:27 pm
2 stops29h 30m
$209
SyracuseDes Moines
SYR - DSM
SYRDSM
Syracuse Hancock Intl
Fri 8/7
8:41 pm-10:23 am
1 stop14h 42m
$222
SyracuseDes Moines
SYR - DSM
SYRDSM
Syracuse Hancock Intl
Fri 8/7
7:52 pm-11:44 pm
1 stop4h 52m
$304
Quickest one-way
SyracuseDes Moines
SYR - DSM
SYRDSM
Syracuse Hancock Intl
Wed 7/29
5:49 pm-9:22 pm
1 stop4h 33m
$304
SyracuseDes Moines
SYR - DSM
SYRDSM
Syracuse Hancock Intl
Tue 7/7
3:46 pm-10:29 pm
1 stop7h 43m
$379
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Syracuse to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Syracuse to Des Moines in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Syracuse-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Syracuse-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Syracuse-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Syracuse-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Syracuse-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Syracuse to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Syracuse with our price prediction graph.
SYR-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Syracuse to Des Moines
What is the cheapest month to book a flight from Syracuse to Des Moines?
Currently, September is the cheapest month in which you can book a flight from Syracuse to Des Moines (average of $308). Flying from Syracuse to Des Moines in August is currently the most expensive (average of $788). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Syracuse to Des Moines?
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated June 24, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Syracuse to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Comfort
7.8
Food
7.2
Crew
8.5
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Overall
7.8
Comfort
7.8
Food
7.2
Crew
8.5
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Overall
7.8
Comfort
7.8
Food
7.2
Crew
8.5
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Overall
7.8
Comfort
7.8
Food
7.2
Crew
8.5
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Related info for your journey
Find useful and relevant information for your journey from Syracuse to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Ames
Clive
Johnston
Boone
West Des Moines
Ankeny
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Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 24, 2026.
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Syracuse and Des Moines flights
Browse other Syracuse and Des Moines flight options. Last updated on June 24, 2026.
Other flights from Syracuse
Browse through other flights departing from Syracuse. Flights are based on user searches made on Cheapflights and were last updated on June 24, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Syracuse to Des Moines
Discover the top 3 airlines that operate flights from Syracuse to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$393 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$258 | Average$434 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$301 | Average$342 | FlexibilityNo cancel fee | On-time69% |