HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Des Moines

$259+ Cheap flights from Syracuse to Des Moines (SYR - DSM)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/24. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — DSM
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Syracuse to Des Moines with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Syracuse to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Syracuse (SYR) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$259
(American Airlines)

Popular in

July

Cheapest in

January

Average price

$390
From Syracuse Hancock Intl to Des Moines
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($57 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from Syracuse to Des Moines

Cheapest flights from Syracuse to Des Moines
Explore the most affordable flight options available from Syracuse to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/245:37 pmSYR - DSM
1 stop7h 22mAmerican Airlines
Mon 10/276:07 pmDSM - SYR
1 stop4h 22mAmerican Airlines
Deal found 9/15$259
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/245:37 pmSYR - DSM
1 stop7h 22mAmerican Airlines
Sun 10/266:22 pmDSM - SYR
1 stop4h 58mAmerican Airlines
Deal found 9/15$274
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/305:43 pmSYR - DSM
1 stop5h 07mUnited Airlines
Sat 10/43:25 pmDSM - SYR
1 stop5h 03mUnited Airlines
Deal found 9/15$289
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/236:00 amSYR - DSM
1 stop4h 20mDelta
Wed 10/293:15 pmDSM - SYR
1 stop6h 51mDelta
Deal found 9/15$299
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/266:15 amSYR - DSM
1 stop5h 17mUnited Airlines
Tue 9/3011:31 amDSM - SYR
1 stop4h 16mUnited Airlines
Deal found 9/14$329
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/246:15 amSYR - DSM
1 stop5h 17mUnited Airlines
Mon 10/273:15 pmDSM - SYR
2 stops6h 58mUnited Airlines
Deal found 9/15$335
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/256:00 amSYR - DSM
2 stops9h 23mUnited Airlines
Sun 9/281:00 pmDSM - SYR
1 stop7h 28mUnited Airlines
Deal found 9/14$364
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/196:47 pmSYR - DSM
1 stop5h 19mAmerican Airlines
Tue 9/233:50 pmDSM - SYR
1 stop6h 50mAmerican Airlines
Deal found 9/16$366
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/196:20 amSYR - DSM
1 stop6h 54mUnited Airlines
Tue 9/231:10 pmDSM - SYR
2 stops9h 36mUnited Airlines
Deal found 9/16$371

Cheapflights Fare Finder

 
Customize your flight search to find flights from Syracuse to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Syracuse to Des Moines that are best for you.

Fly from

Syracuse

Fly to

Des Moines

Route

Depart

Return

Price

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Fri 10/24

5:37 pm-11:59 pm

1 stop7h 22m

Des Moines

Sun 10/26

6:22 pm-12:20 am

1 stop4h 58m

$274

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Tue 9/30

5:43 pm-9:50 pm

1 stop5h 07m

Des Moines

Sat 10/4

3:25 pm-9:28 pm

1 stop5h 03m

$289

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Thu 10/23

6:00 am-9:20 am

1 stop4h 20m

Des Moines

Wed 10/29

3:15 pm-11:06 pm

1 stop6h 51m

$299

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Fri 10/24

6:15 am-10:32 am

1 stop5h 17m

Des Moines

Mon 10/27

3:15 pm-11:13 pm

2 stops6h 58m

$335

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Wed 10/8

6:10 am-2:23 pm

2 stops9h 13m

Des Moines

Tue 10/14

1:00 pm-11:58 am

1 stop21h 58m

$428

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Thu 10/23

6:00 am-2:23 pm

2 stops9h 23m

Des Moines

Wed 10/29

5:14 pm-9:50 am

2 stops15h 36m

$437

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Sat 11/22

6:15 am-10:42 am

1 stop5h 27m

Des Moines

Sat 11/29

9:44 pm-2:55 am

1 stop4h 11m

$446

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Best time to book a flight from Syracuse to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Syracuse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Syracuse to Des Moines

What is the cheapest month to book a flight from Syracuse to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Syracuse to Des Moines (average of $336). Flying from Syracuse to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SYR to DSM?

Find hourly flight availability from Syracuse to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

One of the essential ways to save on airfare from Syracuse to Des Moines is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the afternoon could potentially save you up to 18% on airfare.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated September 17, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Syracuse to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,961 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Syracuse to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Syracuse to Des Moines?

    There are many flights that can get you from Syracuse to Des Moines in 4h 20m. Fly via American Airlines, United Airlines, or Delta to get the fastest option. The distance between Syracuse and Des Moines is about 901 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Syracuse to Des Moines round-trip?

    Currently priced at $198, American Airlines will fly you from Syracuse to Des Moines and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and United Airlines - these airlines can fly you to your destination from $258 and $300, respectively. You may be able to fly from Syracuse to Des Moines for 45% less than the average price by searching for these airlines.

  • Can I find deals for flights from Syracuse to Des Moines that include hotel bookings?

    Yes. In addition to deals on Syracuse to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Syracuse to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Syracuse to Des Moines.

  • Can I find deals for business class flights from Syracuse to Des Moines?

    Yes. Cheapflights offers flight deals from Syracuse to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Syracuse to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Syracuse to Des Moines (average of $336). Flying from Syracuse to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Syracuse to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
LaGuardia to Omaha flights
John F Kennedy Intl to Omaha flights
Newark to Omaha flights
John F Kennedy Intl to Des Moines flights
John F Kennedy Intl to Cedar Rapids flights
Newark to Cedar Rapids flights
LaGuardia to Des Moines flights
LaGuardia to Cedar Rapids flights
White Plains to Omaha flights
LaGuardia to Moline flights
John F Kennedy Intl to Moline flights
Newark to Moline flights
Newark to Des Moines flights
Syracuse to Omaha flights
White Plains to Des Moines flights
Buffalo to Cedar Rapids flights
Buffalo to Des Moines flights
Albany to Moline flights
Albany to Cedar Rapids flights
White Plains to Cedar Rapids flights
Syracuse to Cedar Rapids flights
Rochester to Moline flights
Albany to Omaha flights
Elmira to Omaha flights
White Plains to Moline flights
Albany to Des Moines flights
Ithaca to Cedar Rapids flights
Rochester to La Crosse flights
Rochester to Omaha flights
Stewart to Des Moines flights
Buffalo to Omaha flights
Syracuse to Moline flights
Rochester to Cedar Rapids flights
Ithaca to Omaha flights
Rochester to Des Moines flights
Rochester to Sioux City flights
Newark to La Crosse flights
Ithaca to Des Moines flights
Newark to Sioux City flights
John F Kennedy Intl to La Crosse flights
LaGuardia to Sioux City flights
LaGuardia to Waterloo flights
Binghamton to Des Moines flights
Newark to Waterloo flights
Stewart to Cedar Rapids flights
Syracuse to La Crosse flights
LaGuardia to La Crosse flights
John F Kennedy Intl to Waterloo flights
Binghamton to Omaha flights

Top 3 airlines flying from Syracuse to Des Moines

Discover the top 3 airlines that operate flights from Syracuse to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$343FlexibilityNo cancel feeOn-time71%
DeltaCheapest$258Average$392FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$300Average$361FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.