$251+ Cheap flights from Syracuse to Des Moines (SYR - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/14. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — DSM
Oct 3 — Oct 101
Round-trip
1 adult, Economy
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Find cheap flights from Syracuse to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Syracuse to Des Moines
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Best
Last-minute
One-way
Cheapest flights from Syracuse to Des MoinesExplore the most affordable flight options available from Syracuse to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 3, 2026.
Explore the most affordable flight options available from Syracuse to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 3, 2026.
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/205:00 am -
1 stop5h 12m
Wed 1/209:37 am -
1 stop7h 34m
Deal found 8/31![American Airlines logo]()
$329
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/205:00 am -
1 stop5h 12m
Sat 1/231:51 pm -
2 stops8h 55m
Deal found 8/31![American Airlines logo]()
$334
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3110:30 am -
2 stops9h 30m
Sat 11/77:23 am -
2 stops8h 24m
Deal found 9/1![American Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:40 pm -
1 stop7h 01m
Mon 9/285:57 pm -
1 stop5h 10m
Deal found 9/2![American Airlines logo]()
$354
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:33 pm -
2 stops7h 53m
Sat 11/77:23 am -
2 stops8h 24m
Deal found 9/1![American Airlines logo]()
$364
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:20 am -
1 stop4h 18m
Mon 9/215:59 pm -
1 stop4h 48m
Deal found 9/2![Delta logo]()
$379
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:07 am -
1 stop5h 24m
Wed 10/281:27 pm -
1 stop8h 26m
Deal found 9/2![United Airlines logo]()
$409
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:00 am -
2 stops9h 20m
Mon 9/213:22 pm -
1 stop4h 37m
Deal found 9/2![United Airlines logo]()
$426
Best flights from Syracuse to Des MoinesDiscover carefully curated flight deals from Syracuse to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 3, 2026.
Discover carefully curated flight deals from Syracuse to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 3, 2026.
This Delta deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/16:22 am -
1 stop4h 20m
Sat 11/75:50 pm -
1 stop4h 28m
Deal found 9/1![Delta logo]()
$329
This American Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:40 pm -
1 stop7h 01m
Mon 9/285:57 pm -
1 stop5h 10m
Deal found 8/29![American Airlines logo]()
$329
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/315:20 pm -
1 stop5h 35m
Sat 11/73:15 pm -
2 stops7h 28m
Deal found 9/1![United Airlines logo]()
$334
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3110:30 am -
2 stops9h 30m
Sat 11/77:23 am -
2 stops8h 24m
Deal found 9/1![American Airlines logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/248:05 am -
1 stop9h 15m
Wed 10/289:00 am -
2 stops13h 43m
Deal found 9/2![United Airlines logo]()
$414
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:20 am -
1 stop7h 46m
Sun 9/275:59 pm -
1 stop4h 50m
Deal found 9/2![Delta logo]()
$433
Last-minute flights from Syracuse to Des MoinesDiscover last-minute flight deals from Syracuse to Des Moines. Data last updated September 3, 2026 and is based on user searches.
Discover last-minute flight deals from Syracuse to Des Moines. Data last updated September 3, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:20 am -
1 stop4h 18m
Mon 9/215:59 pm -
1 stop4h 48m
Deal found 9/2![Delta logo]()
$379
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:00 am -
2 stops9h 20m
Mon 9/213:22 pm -
1 stop4h 37m
Deal found 9/2![United Airlines logo]()
$426
This American Airlines deal was found by Cheapflights users on 8/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:40 pm -
1 stop7h 01m
Mon 9/285:57 pm -
1 stop5h 10m
Deal found 8/29![American Airlines logo]()
$329
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:20 am -
1 stop7h 46m
Sun 9/275:59 pm -
1 stop4h 50m
Deal found 9/2![Delta logo]()
$433
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:07 am -
1 stop5h 24m
Wed 10/281:27 pm -
1 stop8h 26m
Deal found 9/2![United Airlines logo]()
$409
This United Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/315:20 pm -
1 stop5h 35m
Sat 11/73:15 pm -
2 stops7h 28m
Deal found 9/1![United Airlines logo]()
$334
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3110:30 am -
2 stops9h 30m
Sat 11/77:23 am -
2 stops8h 24m
Deal found 9/1![American Airlines logo]()
$339
One-way flights from Syracuse to Des MoinesSearch for one-way flight options from Syracuse to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 3, 2026.
Search for one-way flight options from Syracuse to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 3, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/143:20 pm -
3 stops24h 22m
Deal found 8/31![Multiple Airlines logo]()
$251
This Delta deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:20 pm -
1 stop4h 20m
Deal found 8/31![Delta logo]()
$309
This American Airlines deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:36 pm -
2 stops7h 38m
Deal found 8/31![American Airlines logo]()
$314
Find flight deals from Syracuse to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Syracuse (SYR) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $329 (American Airlines) |
One-way from | $251 (Kiwi.com) |
Popular in | April |
Cheapest in | December |
Average price | $328 |
Cheapflights Fare Finder
Customize your flight search to find flights from Syracuse to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 3, 2026.
Use the filters below to find and compare flights from Syracuse to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Sun 11/1
6:22 am-9:42 am
1 stop4h 20m
Des Moines
Sat 11/7
5:50 pm-11:18 pm
1 stop4h 28m
$329
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Fri 9/25
5:40 pm-11:41 pm
1 stop7h 01m
Des Moines
Mon 9/28
5:57 pm-12:07 am
1 stop5h 10m
$329
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Sat 10/31
5:20 pm-9:55 pm
1 stop5h 35m
Des Moines
Sat 11/7
3:15 pm-11:43 pm
2 stops7h 28m
$334
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Sat 10/31
10:30 am-7:00 pm
2 stops9h 30m
Des Moines
Sat 11/7
7:23 am-4:47 pm
2 stops8h 24m
$339
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Sat 10/24
8:05 am-4:20 pm
1 stop9h 15m
Des Moines
Wed 10/28
9:00 am-11:43 pm
2 stops13h 43m
$414
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Fri 9/25
7:20 am-2:06 pm
1 stop7h 46m
Des Moines
Sun 9/27
5:59 pm-11:49 pm
1 stop4h 50m
$433
Cheapest one-way
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Wed 10/14
3:20 pm-2:42 pm
3 stops24h 22m
$251
Quickest one-way
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Wed 10/14
5:20 pm-8:40 pm
1 stop4h 20m
$309
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Wed 10/14
5:36 pm-12:14 am
2 stops7h 38m
$314
Sorted by cheapest first
Compare providers for flights from Syracuse to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Syracuse to Des Moines in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Syracuse-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Syracuse-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Syracuse-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Syracuse-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Syracuse-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Syracuse to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Syracuse with our price prediction graph.
SYR-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Syracuse to Des Moines
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated September 3, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Syracuse to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Entertainment
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Overall
7.8
Entertainment
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Overall
7.8
Entertainment
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Overall
7.8
Entertainment
7.8
Crew
8.5
Food
7.2
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Related info for your journey
Find useful and relevant information for your journey from Syracuse to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
Ames
Johnston
Boone
Norwalk
West Des Moines
Ankeny
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Complete your trip to Des Moines by adding a car rental and/or hotel reservation to your travel itinerary.
Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 3, 2026.
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Find flights from Syracuse to Des Moines, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Syracuse and Des Moines flights
Browse other Syracuse and Des Moines flight options. Last updated on September 3, 2026.
Other flights from Syracuse
Browse through other flights departing from Syracuse. Flights are based on user searches made on Cheapflights and were last updated on September 3, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Syracuse to Des Moines
Discover the top 3 airlines that operate flights from Syracuse to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$270 | Average$458 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$305 | Average$366 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$305 | Average$393 | FlexibilityNo cancel fee | On-time71% |