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Des Moines

$176+ Cheap flights from Syracuse to Des Moines (SYR - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/13. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — DSM
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Find flight deals from Syracuse to Des Moines

Cheapest flights from Syracuse to Des Moines
Explore the most affordable flight options available from Syracuse to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/148:06 pmSYR - DSM
1 stop4h 44mAmerican Airlines
Tue 11/185:04 pmDSM - SYR
1 stop5h 19mAmerican Airlines
Deal found 10/30$309
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/146:15 amSYR - DSM
2 stops10h 57mUnited Airlines
Tue 11/185:45 amDSM - SYR
2 stops9h 55mUnited Airlines
Deal found 10/30$389
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/18:00 amSYR - DSM
1 stop9h 13mUnited Airlines
Sun 11/211:26 amDSM - SYR
1 stop4h 14mUnited Airlines
Deal found 10/29$401
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/25:15 amSYR - DSM
1 stop5h 15mUnited Airlines
Sat 11/88:02 amDSM - SYR
2 stops9h 51mUnited Airlines
Deal found 10/30$595
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/37:08 amSYR - DSM
1 stop8h 23mAmerican Airlines
Wed 11/55:42 amDSM - SYR
1 stop4h 27mAmerican Airlines
Deal found 10/30$768
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/311:34 amSYR - DSM
2 stops10h 11mUnited Airlines
Wed 11/53:15 pmDSM - SYR
1 stop4h 47mUnited Airlines
Deal found 10/30$773

Cheap flight deals from Syracuse to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Syracuse (SYR) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 30, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$309
(American Airlines)

One-way from

$176
(Kiwi.com)

Popular in

October

Cheapest in

January

Average price

$456
Provider with most accurate pricing for Syracuse Hancock Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Syracuse Hancock Intl-Des Moines flights.
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From Syracuse Hancock Intl to Des Moines
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One-way flight from Syracuse Hancock Intl to Des Moines
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High demand for flights, 0% potential price rise
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Syracuse to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Syracuse to Des Moines that are best for you.

Fly from

Syracuse

Fly to

Des Moines

Route

Depart

Return

Price

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Fri 11/14

8:06 pm-11:50 pm

1 stop4h 44m

Des Moines

Tue 11/18

5:04 pm-11:23 pm

1 stop5h 19m

$309

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Fri 11/14

6:15 am-4:12 pm

2 stops10h 57m

Des Moines

Tue 11/18

5:45 am-4:40 pm

2 stops9h 55m

$389

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Mon 4/6

6:30 am-10:20 am

1 stop4h 50m

Des Moines

Fri 4/10

6:45 pm-10:02 am

1 stop14h 17m

$452

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Sat 11/22

6:03 am-1:29 pm

1 stop8h 26m

Des Moines

Sat 11/29

8:51 am-11:18 pm

1 stop13h 27m

$966

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Sat 12/13

2:43 pm-2:06 pm

1 stop24h 23m

$176

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Sat 12/13

6:00 am-2:34 pm

2 stops9h 34m

$276

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Thu 11/6

9:12 pm-5:08 pm

1 stop20h 56m

$302

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Fri 11/7

12:03 pm-10:00 am

2 stops46h 57m

$308

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Thu 11/6

7:40 pm-2:58 pm

2 stops20h 18m

$338

SyracuseDes Moines

SYR - DSM

SYRDSM

Syracuse Hancock Intl

Thu 11/6

5:45 am-4:12 pm

2 stops11h 27m

$422

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Compare providers for flights from Syracuse to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Syracuse to Des Moines in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
MytripPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Syracuse-Des Moines flights, users find the pricing of Mytrip to be most consistent on Cheapflights vs. Mytrip Users can find the same prices on Syracuse-Des Moines flight deals on Cheapflights vs. Mytrip >95% of the time. Price accuracy is based on data collected from Syracuse-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Syracuse-Des Moines flights, Cheapflights users trust Mytrip the most. Mytrip has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Syracuse-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Syracuse to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Syracuse with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Syracuse to Des Moines

What is the cheapest month to book a flight from Syracuse to Des Moines?

Currently, April is the cheapest month in which you can book a flight from Syracuse to Des Moines (average of $201). Flying from Syracuse to Des Moines in March is currently the most expensive (average of $374). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SYR to DSM?

Find hourly flight availability from Syracuse to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

One of the essential ways to save on airfare from Syracuse to Des Moines is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the afternoon could potentially save you up to 17% on airfare.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated October 30, 2025.
Read reviews from past customers who have flown Delta, United Airlines, and American Airlines from Syracuse to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,998 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
7,998 reviews
Delta
7.9
Good
7,998 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
United Airlines
7.4
Good
8,998 reviews
Delta
7.9
Good
7,998 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
American Airlines
7.2
Good
11,035 reviews
Delta
7.9
Good
7,998 reviews

Entertainment

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Comfort

7.9

Overall

7.9

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Syracuse to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Syracuse to Des Moines?

    There are many flights that can get you from Syracuse to Des Moines in 4h 44m. Fly via American Airlines or United Airlines to get the fastest option. The distance between Syracuse and Des Moines is about 901 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Syracuse to Des Moines round-trip?

    Currently priced at $198, American Airlines will fly you from Syracuse to Des Moines and back. In addition to American Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and United Airlines - these airlines can fly you to your destination from $258 and $300, respectively. You may be able to fly from Syracuse to Des Moines for 45% less than the average price by searching for these airlines.

  • Can I find deals for flights from Syracuse to Des Moines that include hotel bookings?

    Yes. In addition to deals on Syracuse to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Syracuse to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Syracuse to Des Moines.

  • Can I find deals for business class flights from Syracuse to Des Moines?

    Yes. Cheapflights offers flight deals from Syracuse to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Syracuse to Des Moines?

    Currently, April is the cheapest month in which you can book a flight from Syracuse to Des Moines (average of $201). Flying from Syracuse to Des Moines in March is currently the most expensive (average of $374). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Top 3 airlines flying from Syracuse to Des Moines

Discover the top 3 airlines that operate flights from Syracuse to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$198Average$323FlexibilityNo cancel feeOn-time71%
DeltaCheapest$258Average$370FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$300Average$342FlexibilityNo cancel feeOn-time69%

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