$349+ Cheap flights from Syracuse to Des Moines (SYR - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/4. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — DSM
Nov 13 — Nov 201
Round-trip
1 adult, Economy
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Find cheap flights from Syracuse to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Syracuse to Des Moines
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Best
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Cheapest flights from Syracuse to Des MoinesExplore the most affordable flight options available from Syracuse to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2026.
Explore the most affordable flight options available from Syracuse to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2026.
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/205:00 am -
1 stop5h 12m
Wed 1/2010:26 am -
1 stop6h 44m
Deal found 10/9![American Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:40 pm -
1 stop6h 46m
Wed 11/187:23 am -
2 stops8h 36m
Deal found 10/11![American Airlines logo]()
$354
This Delta deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:22 am -
1 stop4h 20m
Tue 11/175:29 pm -
1 stop4h 25m
Deal found 10/12![Delta logo]()
$357
This Delta deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1912:12 pm -
1 stop8h 06m
Sun 11/225:29 pm -
1 stop4h 25m
Deal found 10/12![Delta logo]()
$365
This Delta deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/512:10 pm -
1 stop8h 04m
Tue 11/105:29 pm -
1 stop4h 25m
Deal found 10/13![Delta logo]()
$367
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:40 pm -
1 stop6h 46m
Wed 11/189:25 am -
1 stop7h 41m
Deal found 10/11![American Airlines logo]()
$372
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:58 pm -
1 stop6h 16m
Sat 10/316:05 am -
1 stop7h 05m
Deal found 10/12![American Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:00 am -
1 stop5h 32m
Wed 11/185:30 am -
2 stops10h 09m
Deal found 10/11![United Airlines logo]()
$401
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:33 pm -
1 stop6h 06m
Tue 11/179:25 am -
1 stop5h 58m
Deal found 10/12![American Airlines logo]()
$408
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2710:17 am -
2 stops8h 10m
Sat 10/316:05 am -
2 stops7h 07m
Deal found 10/12![United Airlines logo]()
$409
Best flights from Syracuse to Des MoinesDiscover carefully curated flight deals from Syracuse to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 14, 2026.
Discover carefully curated flight deals from Syracuse to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 14, 2026.
This American Airlines deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/205:00 am -
1 stop5h 12m
Wed 1/2010:26 am -
1 stop6h 44m
Deal found 10/9![American Airlines logo]()
$349
This Delta deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/197:15 am -
1 stop5h 41m
Sat 1/236:20 am -
1 stop4h 35m
Deal found 10/9![Delta logo]()
$365
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2710:17 am -
2 stops8h 10m
Sat 10/316:05 am -
2 stops7h 07m
Deal found 10/12![United Airlines logo]()
$409
This Delta deal was found by Cheapflights users on 10/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/216:00 am -
1 stop4h 55m
Sat 1/236:20 am -
1 stop4h 35m
Deal found 10/9![Delta logo]()
$365
This American Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:33 pm -
1 stop6h 06m
Tue 11/107:23 am -
2 stops8h 36m
Deal found 10/13![American Airlines logo]()
$413
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/55:25 pm -
1 stop5h 00m
Wed 12/98:00 am -
1 stop4h 40m
Deal found 10/13![United Airlines logo]()
$449
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:40 pm -
1 stop6h 46m
Tue 11/177:23 am -
2 stops8h 36m
Deal found 10/11![American Airlines logo]()
$413
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:40 am -
2 stops9h 46m
Wed 11/186:05 am -
2 stops7h 07m
Deal found 10/11![United Airlines logo]()
$475
This United Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:07 am -
1 stop5h 24m
Sun 10/251:27 pm -
1 stop8h 26m
Deal found 10/10![United Airlines logo]()
$484
Last-minute flights from Syracuse to Des MoinesDiscover last-minute flight deals from Syracuse to Des Moines. Data last updated October 14, 2026 and is based on user searches.
Discover last-minute flight deals from Syracuse to Des Moines. Data last updated October 14, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:58 pm -
1 stop6h 16m
Sat 10/316:05 am -
1 stop7h 05m
Deal found 10/12![American Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2710:17 am -
2 stops8h 10m
Sat 10/316:05 am -
2 stops7h 07m
Deal found 10/12![United Airlines logo]()
$409
This Delta deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:22 am -
1 stop4h 20m
Wed 11/185:29 pm -
1 stop4h 25m
Deal found 10/11![Delta logo]()
$349
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:40 pm -
1 stop6h 46m
Wed 11/187:23 am -
2 stops8h 36m
Deal found 10/11![American Airlines logo]()
$354
This Delta deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:22 am -
1 stop4h 20m
Tue 11/175:29 pm -
1 stop4h 25m
Deal found 10/12![Delta logo]()
$357
This Delta deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/512:10 pm -
1 stop8h 04m
Tue 11/105:29 pm -
1 stop4h 25m
Deal found 10/13![Delta logo]()
$367
This United Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:00 am -
1 stop5h 32m
Wed 11/185:30 am -
2 stops10h 09m
Deal found 10/11![United Airlines logo]()
$401
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:33 pm -
1 stop6h 06m
Tue 11/179:25 am -
1 stop5h 58m
Deal found 10/12![American Airlines logo]()
$408
This American Airlines deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:40 pm -
1 stop6h 46m
Wed 11/189:25 am -
1 stop7h 41m
Deal found 10/11![American Airlines logo]()
$372
This Delta deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1912:12 pm -
1 stop8h 06m
Sun 11/225:29 pm -
1 stop4h 25m
Deal found 10/12![Delta logo]()
$365
Find flight deals from Syracuse to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Syracuse (SYR) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 14, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $349 (American Airlines) |
Popular in | April |
Cheapest in | December |
Average price | $532 |
Cheapflights Fare Finder
Customize your flight search to find flights from Syracuse to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 14, 2026.
Use the filters below to find and compare flights from Syracuse to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Sun 12/20
5:00 am-9:12 am
1 stop5h 12m
Des Moines
Wed 1/20
10:26 am-6:10 pm
1 stop6h 44m
$349
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Sat 12/19
7:15 am-11:56 am
1 stop5h 41m
Des Moines
Sat 1/23
6:20 am-11:55 am
1 stop4h 35m
$365
Quickest round-trip
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Mon 12/21
6:00 am-9:55 am
1 stop4h 55m
Des Moines
Sat 1/23
6:20 am-11:55 am
1 stop4h 35m
$365
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Tue 10/27
10:17 am-5:27 pm
2 stops8h 10m
Des Moines
Sat 10/31
6:05 am-2:12 pm
2 stops7h 07m
$409
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Thu 11/5
5:33 pm-10:39 pm
1 stop6h 06m
Des Moines
Tue 11/10
7:23 am-4:59 pm
2 stops8h 36m
$413
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Thu 11/5
6:40 pm-12:26 am
1 stop6h 46m
Des Moines
Tue 11/17
7:23 am-4:59 pm
2 stops8h 36m
$413
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Sat 12/5
5:25 pm-9:25 pm
1 stop5h 00m
Des Moines
Wed 12/9
8:00 am-1:40 pm
1 stop4h 40m
$449
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Thu 11/5
5:40 am-2:26 pm
2 stops9h 46m
Des Moines
Wed 11/18
6:05 am-2:12 pm
2 stops7h 07m
$475
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Fri 10/23
6:07 am-10:31 am
1 stop5h 24m
Des Moines
Sun 10/25
1:27 pm-10:53 pm
1 stop8h 26m
$484
Sorted by cheapest first
Compare providers for flights from Syracuse to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Syracuse to Des Moines in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Syracuse-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Syracuse-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Syracuse-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Syracuse-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Syracuse-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Syracuse to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Syracuse with our price prediction graph.
SYR-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Syracuse to Des Moines
What is the cheapest month to book a flight from Syracuse to Des Moines?
Currently, December is the cheapest month in which you can book a flight from Syracuse to Des Moines (average of $328). Flying from Syracuse to Des Moines in April is currently the most expensive (average of $619). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Syracuse to Des Moines?
Airfare is typical for this route at the moment.
Syracuse to Des Moines flights typically cost between $348 and $558 in December.The cheapest round-trip price found within the last 5 days was $349 on American Airlines (Dec 20-Jan 20).
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated October 14, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Syracuse to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.8
Comfort
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Food
7.2
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.8
Comfort
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Food
7.2
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.8
Comfort
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Food
7.2
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.8
Comfort
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Related info for your journey
Find useful and relevant information for your journey from Syracuse to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
West Des Moines
Ames
Johnston
Boone
Norwalk
Ankeny
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Syracuse and Des Moines flights
Browse other Syracuse and Des Moines flight options. Last updated on October 14, 2026.
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Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Syracuse to Des Moines
Discover the top 3 airlines that operate flights from Syracuse to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 14, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$375 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$270 | Average$451 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$308 | Average$384 | FlexibilityNo cancel fee | On-time71% |