$211+ Cheap flights from Syracuse to Des Moines (SYR - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/11. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — DSM
Dec 10 — Dec 171
Round-trip
1 adult, Economy
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Find cheap flights from Syracuse to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Syracuse to Des Moines
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Best
Last-minute
One-way
Cheapest flights from Syracuse to Des MoinesExplore the most affordable flight options available from Syracuse to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 10, 2026.
Explore the most affordable flight options available from Syracuse to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 10, 2026.
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/186:00 am -
1 stop14h 09m
Sun 12/203:26 pm -
2 stops7h 37m
Deal found 11/5![American Airlines logo]()
$537
This Delta deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:00 am -
1 stop4h 46m
Wed 11/256:13 am -
1 stop5h 46m
Deal found 11/6![Delta logo]()
$538
This United Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/212:55 pm -
2 stops8h 00m
Wed 11/251:27 pm -
1 stop8h 26m
Deal found 11/6![United Airlines logo]()
$559
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/205:39 am -
1 stop6h 09m
Tue 11/2411:28 am -
1 stop6h 12m
Deal found 11/5![American Airlines logo]()
$627
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:37 pm -
1 stop6h 42m
Thu 12/39:23 am -
1 stop6h 01m
Deal found 11/9![American Airlines logo]()
$657
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2010:17 am -
2 stops12h 38m
Tue 11/248:00 am -
2 stops9h 53m
Deal found 11/5![United Airlines logo]()
$764
This United Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:20 pm -
1 stop5h 35m
Sat 11/288:00 am -
1 stop7h 39m
Deal found 11/8![United Airlines logo]()
$915
Best flights from Syracuse to Des MoinesDiscover carefully curated flight deals from Syracuse to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 10, 2026.
Discover carefully curated flight deals from Syracuse to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 10, 2026.
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/45:33 am -
1 stop5h 26m
Mon 1/186:18 am -
1 stop4h 22m
Deal found 11/9![Delta logo]()
$375
This United Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/88:00 am -
1 stop9h 11m
Tue 1/121:35 pm -
1 stop9h 08m
Deal found 11/6![United Airlines logo]()
$459
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/186:00 am -
1 stop14h 09m
Sun 12/203:26 pm -
2 stops7h 37m
Deal found 11/5![American Airlines logo]()
$537
This Delta deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/36:10 am -
1 stop4h 45m
Mon 1/186:18 am -
1 stop4h 22m
Deal found 11/7![Delta logo]()
$435
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/162:54 pm -
2 stops9h 20m
Wed 1/201:35 pm -
1 stop9h 08m
Deal found 11/5![United Airlines logo]()
$464
This Delta deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:00 am -
1 stop4h 46m
Wed 11/256:13 am -
1 stop5h 46m
Deal found 11/6![Delta logo]()
$538
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/205:39 am -
1 stop6h 09m
Tue 11/2411:28 am -
1 stop6h 12m
Deal found 11/5![American Airlines logo]()
$627
This United Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/212:55 pm -
2 stops8h 00m
Wed 11/258:00 am -
2 stops9h 53m
Deal found 11/6![United Airlines logo]()
$594
Last-minute flights from Syracuse to Des MoinesDiscover last-minute flight deals from Syracuse to Des Moines. Data last updated November 10, 2026 and is based on user searches.
Discover last-minute flight deals from Syracuse to Des Moines. Data last updated November 10, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/205:39 am -
1 stop6h 09m
Tue 11/2411:28 am -
1 stop6h 12m
Deal found 11/5![American Airlines logo]()
$627
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2010:17 am -
2 stops12h 38m
Tue 11/248:00 am -
2 stops9h 53m
Deal found 11/5![United Airlines logo]()
$764
This Delta deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:00 am -
1 stop4h 46m
Wed 11/256:13 am -
1 stop5h 46m
Deal found 11/6![Delta logo]()
$538
This United Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/212:55 pm -
2 stops8h 00m
Wed 11/251:27 pm -
1 stop8h 26m
Deal found 11/6![United Airlines logo]()
$559
This United Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/215:20 pm -
1 stop5h 35m
Sat 11/288:00 am -
1 stop7h 39m
Deal found 11/8![United Airlines logo]()
$915
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:37 pm -
1 stop6h 42m
Thu 12/39:23 am -
1 stop6h 01m
Deal found 11/9![American Airlines logo]()
$657
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/186:00 am -
1 stop14h 09m
Sun 12/203:26 pm -
2 stops7h 37m
Deal found 11/5![American Airlines logo]()
$537
One-way flights from Syracuse to Des MoinesSearch for one-way flight options from Syracuse to Des Moines. Find affordable one-way fares based on user searches. Data last updated November 10, 2026.
Search for one-way flight options from Syracuse to Des Moines. Find affordable one-way fares based on user searches. Data last updated November 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1112:24 pm -
2 stops10h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Multiple Airlines logo]()
$211
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/107:29 pm -
1 stop27h 04m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Multiple Airlines logo]()
$269
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:35 pm -
1 stop6h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![American Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/105:30 am -
2 stops9h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![American Airlines logo]()
$329
This deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/125:25 pm -
1 stop5h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![United Airlines logo]()
$358
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/169:24 am -
1 stop10h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/5![Multiple Airlines logo]()
$401
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1612:00 pm -
2 stops10h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/5![American Airlines logo]()
$464
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:00 am -
3 stops17h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/5![United Airlines logo]()
$1,053
Find flight deals from Syracuse to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Syracuse (SYR) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $375 (Delta) |
One-way from | $211 (Kiwi.com) |
Popular in | April |
Cheapest in | December |
Average price | $414 |
Cheapflights Fare Finder
Customize your flight search to find flights from Syracuse to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 10, 2026.
Use the filters below to find and compare flights from Syracuse to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Fri 12/11
12:24 pm-10:21 pm
2 stops10h 57m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$211
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Thu 12/10
7:29 pm-9:33 pm
1 stop27h 04m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$269
Quickest round-trip
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Sat 12/12
5:25 pm-9:25 pm
1 stop5h 00m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$358
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Mon 1/4
5:33 am-9:59 am
1 stop5h 26m
Des Moines
Mon 1/18
6:18 am-11:40 am
1 stop4h 22m
$375
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Mon 11/16
9:24 am-7:14 pm
1 stop10h 50m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$401
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Sun 1/3
6:10 am-9:55 am
1 stop4h 45m
Des Moines
Mon 1/18
6:18 am-11:40 am
1 stop4h 22m
$435
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Fri 1/8
8:00 am-4:11 pm
1 stop9h 11m
Des Moines
Tue 1/12
1:35 pm-11:43 pm
1 stop9h 08m
$459
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Mon 11/16
12:00 pm-9:20 pm
2 stops10h 20m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$464
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Sat 1/16
2:54 pm-11:14 pm
2 stops9h 20m
Des Moines
Wed 1/20
1:35 pm-11:43 pm
1 stop9h 08m
$464
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Fri 12/18
6:00 am-7:09 pm
1 stop14h 09m
Des Moines
Sun 12/20
3:26 pm-12:03 am
2 stops7h 37m
$537
Showing 1-10 of 14 resultsSorted by cheapest first
Compare providers for flights from Syracuse to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Syracuse to Des Moines in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Syracuse-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Syracuse-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Syracuse-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Syracuse-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Syracuse-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Syracuse to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Syracuse with our price prediction graph.
SYR-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Syracuse to Des Moines
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated November 10, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Syracuse to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Overall
7.8
Food
7.2
Crew
8.5
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Overall
7.8
Food
7.2
Crew
8.5
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Overall
7.8
Food
7.2
Crew
8.5
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Entertainment
7.8
Boarding
8.1
Comfort
7.8
Overall
7.8
Food
7.2
Crew
8.5
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Related info for your journey
Find useful and relevant information for your journey from Syracuse to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
West Des Moines
Ames
Johnston
Boone
Norwalk
Ankeny
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Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 10, 2026.
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Syracuse and Des Moines flights
Browse other Syracuse and Des Moines flight options. Last updated on November 10, 2026.
Other flights from Syracuse
Browse through other flights departing from Syracuse. Flights are based on user searches made on Cheapflights and were last updated on November 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Syracuse to Des Moines
Discover the top 3 airlines that operate flights from Syracuse to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$399 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$270 | Average$454 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$308 | Average$384 | FlexibilityNo cancel fee | On-time71% |