$162+ Cheap flights from Syracuse to Des Moines (SYR - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/14. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — DSM
Oct 17 — Oct 241
Round-trip
1 adult, Economy
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Find cheap flights from Syracuse to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Syracuse to Des Moines
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Best
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One-way
Cheapest flights from Syracuse to Des MoinesExplore the most affordable flight options available from Syracuse to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
Explore the most affordable flight options available from Syracuse to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1512:10 pm -
1 stop8h 04m
Thu 10/223:46 pm -
1 stop6h 43m
Deal found 9/15![Delta logo]()
$349
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:07 am -
1 stop6h 41m
Fri 11/275:29 pm -
1 stop4h 25m
Deal found 9/15![Delta logo]()
$372
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:10 am -
1 stop5h 21m
Sat 10/31:27 pm -
1 stop9h 09m
Deal found 9/14![United Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:40 pm -
1 stop6h 46m
Wed 11/2511:28 am -
1 stop6h 12m
Deal found 9/16![American Airlines logo]()
$427
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:07 am -
1 stop5h 24m
Wed 10/281:27 pm -
1 stop8h 26m
Deal found 9/16![United Airlines logo]()
$429
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/253:25 pm -
1 stop7h 11m
Mon 9/286:00 am -
1 stop8h 00m
Deal found 9/14![American Airlines logo]()
$444
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:19 am -
1 stop5h 45m
Tue 9/228:03 am -
1 stop6h 47m
Deal found 9/15![American Airlines logo]()
$448
Best flights from Syracuse to Des MoinesDiscover carefully curated flight deals from Syracuse to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
Discover carefully curated flight deals from Syracuse to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/227:45 am -
1 stop7h 23m
Fri 11/275:29 pm -
1 stop4h 25m
Deal found 9/15![Delta logo]()
$349
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:00 am -
2 stops9h 15m
Sat 10/36:00 am -
2 stops7h 19m
Deal found 9/14![United Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:40 pm -
1 stop7h 01m
Mon 9/286:00 am -
1 stop4h 40m
Deal found 9/12![American Airlines logo]()
$444
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:07 am -
1 stop5h 24m
Wed 10/281:27 pm -
1 stop8h 26m
Deal found 9/14![United Airlines logo]()
$429
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:07 am -
1 stop5h 24m
Mon 10/193:11 pm -
2 stops7h 35m
Deal found 9/15![United Airlines logo]()
$456
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:00 am -
2 stops7h 34m
Thu 10/2211:27 am -
1 stop4h 27m
Deal found 9/15![United Airlines logo]()
$480
Last-minute flights from Syracuse to Des MoinesDiscover last-minute flight deals from Syracuse to Des Moines. Data last updated September 17, 2026 and is based on user searches.
Discover last-minute flight deals from Syracuse to Des Moines. Data last updated September 17, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:19 am -
1 stop5h 45m
Tue 9/228:03 am -
1 stop6h 47m
Deal found 9/15![American Airlines logo]()
$448
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/253:25 pm -
1 stop7h 11m
Mon 9/286:00 am -
1 stop8h 00m
Deal found 9/14![American Airlines logo]()
$444
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2511:05 am -
2 stops9h 16m
Sun 9/276:00 am -
1 stop4h 35m
Deal found 9/13![American Airlines logo]()
$449
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:10 am -
1 stop5h 21m
Sat 10/31:27 pm -
1 stop9h 09m
Deal found 9/14![United Airlines logo]()
$399
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1512:10 pm -
1 stop8h 04m
Thu 10/223:46 pm -
1 stop6h 43m
Deal found 9/15![Delta logo]()
$349
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:07 am -
1 stop5h 24m
Mon 10/193:11 pm -
1 stop4h 46m
Deal found 9/15![United Airlines logo]()
$450
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:07 am -
1 stop5h 24m
Wed 10/281:27 pm -
1 stop8h 26m
Deal found 9/16![United Airlines logo]()
$429
One-way flights from Syracuse to Des MoinesSearch for one-way flight options from Syracuse to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.
Search for one-way flight options from Syracuse to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/146:49 pm -
1 stop17h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Allegiant Air logo]()
$162
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/149:21 pm -
2 stops38h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Multiple Airlines logo]()
$241
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/213:20 pm -
3 stops26h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Multiple Airlines logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2010:54 am -
1 stop29h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Allegiant Air logo]()
$284
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:12 am -
1 stop7h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![American Airlines logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2112:44 pm -
1 stop27h 23m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Allegiant Air logo]()
$322
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2012:24 pm -
2 stops22h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$361
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/213:20 pm -
3 stops47h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![Multiple Airlines logo]()
$409
Find flight deals from Syracuse to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Syracuse (SYR) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $349 (Delta) |
One-way from | $162 (Kiwi.com) |
Popular in | April |
Cheapest in | December |
Average price | $384 |
Cheapflights Fare Finder
Customize your flight search to find flights from Syracuse to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 17, 2026.
Use the filters below to find and compare flights from Syracuse to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Mon 12/14
6:49 pm-11:38 am
1 stop17h 49m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$162
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Wed 10/21
3:20 pm-5:02 pm
3 stops26h 42m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$259
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Mon 12/14
12:24 pm-10:49 am
3 stops47h 25m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$282
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Fri 11/20
10:54 am-3:40 pm
1 stop29h 46m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$302
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Sat 11/21
12:44 pm-3:07 pm
1 stop27h 23m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$322
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Wed 10/21
5:36 pm-12:14 am
2 stops7h 38m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$324
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Sun 11/22
7:45 am-2:08 pm
1 stop7h 23m
Des Moines
Fri 11/27
5:29 pm-10:54 pm
1 stop4h 25m
$349
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Fri 11/20
12:24 pm-10:01 am
2 stops22h 37m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$361
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Tue 9/29
6:00 am-2:15 pm
2 stops9h 15m
Des Moines
Sat 10/3
6:00 am-2:19 pm
2 stops7h 19m
$409
SyracuseDes Moines
SYR Syracuse Hancock Intl - DSM Des Moines
SYRDSM
Syracuse Hancock Intl
Sat 10/24
6:07 am-10:31 am
1 stop5h 24m
Des Moines
Wed 10/28
1:27 pm-10:53 pm
1 stop8h 26m
$429
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Syracuse to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Syracuse to Des Moines in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Syracuse-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Syracuse-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Syracuse-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Syracuse-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Syracuse-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Syracuse to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Syracuse with our price prediction graph.
SYR-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Syracuse to Des Moines
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated September 17, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from Syracuse to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.8
Crew
8.5
Boarding
8.1
Comfort
7.8
Food
7.2
Entertainment
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Overall
7.8
Crew
8.5
Boarding
8.1
Comfort
7.8
Food
7.2
Entertainment
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Overall
7.8
Crew
8.5
Boarding
8.1
Comfort
7.8
Food
7.2
Entertainment
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Overall
7.8
Crew
8.5
Boarding
8.1
Comfort
7.8
Food
7.2
Entertainment
7.8
Reviews
1 / 20
2.0
MediocreBarney,May 2026
JFK - ATL
Related info for your journey
Find useful and relevant information for your journey from Syracuse to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
Ames
Johnston
West Des Moines
Boone
Norwalk
Ankeny
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Syracuse and Des Moines flights
Browse other Syracuse and Des Moines flight options. Last updated on September 17, 2026.
Other flights from Syracuse
Browse through other flights departing from Syracuse. Flights are based on user searches made on Cheapflights and were last updated on September 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from Syracuse to Des Moines
Discover the top 3 airlines that operate flights from Syracuse to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$258 | Average$366 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$270 | Average$458 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$308 | Average$384 | FlexibilityNo cancel fee | On-time71% |