$98+ Cheap flights from San Francisco to Des Moines (SFO - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/3. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — DSM
Aug 31 — Sep 71
Round-trip
1 adult, Economy
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Find cheap flights from San Francisco to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Francisco to Des Moines
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Cheapest flights from San Francisco to Des MoinesExplore the most affordable flight options available from San Francisco to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 1, 2026.
Explore the most affordable flight options available from San Francisco to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 1, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/132:16 pm
SFO
- DSM
1 stop21h 36m
Multiple Airlines
Sun 10/1810:09 pm
DSM
- SFO
1 stop12h 14m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$219
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/273:38 pm
SFO
- DSM
1 stop25h 10m
Multiple Airlines
Sun 8/309:50 pm
DSM
- SFO
1 stop20h 46m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$230
This Expedia deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/286:00 am
SFO
- DSM
1 stop5h 34m
Frontier
Mon 8/312:19 pm
DSM
- SFO
1 stop6h 26m
Frontier
Deal found 7/30![Frontier logo]()
$232
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1711:17 am
SFO
- DSM
1 stop7h 49m
Multiple Airlines
Sun 9/209:56 pm
DSM
- SFO
1 stop12h 18m
Multiple Airlines
Deal found 7/31![Multiple Airlines logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/49:42 am
SFO
- DSM
1 stop31h 51m
Multiple Airlines
Sun 10/1110:09 pm
DSM
- SFO
1 stop12h 14m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$258
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:00 am
SFO
- DSM
1 stop5h 18m
Multiple Airlines
Sun 10/1810:09 pm
DSM
- SFO
1 stop12h 14m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$260
Best flights from San Francisco to Des MoinesDiscover carefully curated flight deals from San Francisco to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 1, 2026.
Discover carefully curated flight deals from San Francisco to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 1, 2026.
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/315:10 am
SFO
- DSM
1 stop5h 55m
Southwest
Tue 11/36:00 am
DSM
- SFO
1 stop8h 50m
Southwest
Deal found 7/30![Southwest logo]()
$301
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2812:08 pm
SFO
- DSM
1 stop6h 54m
Delta
Tue 11/36:55 am
DSM
- SFO
1 stop5h 57m
Delta
Deal found 7/30![Delta logo]()
$380
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2812:55 am
SFO
- DSM
1 stop7h 31m
United Airlines
Tue 11/35:30 am
DSM
- SFO
1 stop5h 59m
United Airlines
Deal found 7/29![United Airlines logo]()
$401
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/46:00 am
SFO
- DSM
1 stop5h 34m
Frontier
Mon 9/72:19 pm
DSM
- SFO
1 stop23h 53m
Frontier
Deal found 7/27![Frontier logo]()
$435
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:00 am
SFO
- DSM
2 stops12h 15m
Southwest
Sat 8/224:50 pm
DSM
- SFO
1 stop6h 35m
Southwest
Deal found 7/28![Southwest logo]()
$362
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/122:20 pm
SFO
- DSM
1 stop7h 13m
United Airlines
Sat 9/261:26 pm
DSM
- SFO
1 stop8h 06m
United Airlines
Deal found 7/27![United Airlines logo]()
$401
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/38:30 am
SFO
- DSM
2 stops10h 50m
Southwest
Sun 9/67:05 am
DSM
- SFO
2 stops9h 05m
Southwest
Deal found 7/27![Southwest logo]()
$366
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:35 am
SFO
- DSM
1 stop7h 56m
United Airlines
Sat 10/31:27 pm
DSM
- SFO
1 stop8h 07m
United Airlines
Deal found 7/28![United Airlines logo]()
$401
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/411:55 am
SFO
- DSM
2 stops7h 35m
Southwest
Sat 10/102:30 pm
DSM
- SFO
1 stop9h 05m
Southwest
Deal found 7/30![Southwest logo]()
$400
This United Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/212:55 am
SFO
- DSM
1 stop7h 31m
United Airlines
Tue 11/33:01 pm
DSM
- SFO
1 stop8h 37m
United Airlines
Deal found 7/29![United Airlines logo]()
$401
This Southwest deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:35 am
SFO
- DSM
1 stop5h 20m
Southwest
Tue 8/257:15 am
DSM
- SFO
2 stops8h 00m
Southwest
Deal found 7/30![Southwest logo]()
$454
Last-minute flights from San Francisco to Des MoinesDiscover last-minute flight deals from San Francisco to Des Moines. Data last updated August 1, 2026 and is based on user searches.
Discover last-minute flight deals from San Francisco to Des Moines. Data last updated August 1, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1112:38 pm
SFO
- DSM
1 stop22h 56m
Multiple Airlines
Mon 8/1710:06 pm
DSM
- SFO
1 stop14h 19m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$306
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1712:25 pm
SFO
- DSM
1 stop6h 34m
Delta
Sat 8/226:55 am
DSM
- SFO
1 stop8h 14m
Delta
Deal found 7/28![Delta logo]()
$301
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/199:35 am
SFO
- DSM
2 stops9h 25m
Southwest
Tue 8/2512:30 pm
DSM
- SFO
2 stops8h 35m
Southwest
Deal found 7/29![Southwest logo]()
$316
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/255:35 pm
SFO
- DSM
2 stops37h 03m
Multiple Airlines
Sun 8/309:50 pm
DSM
- SFO
1 stop24h 06m
Multiple Airlines
Deal found 7/31![Multiple Airlines logo]()
$291
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2511:15 am
SFO
- DSM
2 stops7h 45m
Southwest
Thu 8/272:25 pm
DSM
- SFO
2 stops8h 05m
Southwest
Deal found 7/27![Southwest logo]()
$311
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/273:38 pm
SFO
- DSM
1 stop25h 10m
Multiple Airlines
Sun 8/309:50 pm
DSM
- SFO
1 stop20h 46m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$230
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/273:38 pm
SFO
- DSM
1 stop25h 10m
Multiple Airlines
Thu 9/310:01 pm
DSM
- SFO
1 stop12h 42m
Multiple Airlines
Deal found 7/28![Multiple Airlines logo]()
$300
This Expedia deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/286:00 am
SFO
- DSM
1 stop5h 34m
Frontier
Mon 8/312:19 pm
DSM
- SFO
1 stop6h 26m
Frontier
Deal found 7/30![Frontier logo]()
$232
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/297:00 am
SFO
- DSM
1 stop9h 17m
American Airlines
Sat 9/51:55 pm
DSM
- SFO
1 stop7h 53m
American Airlines
Deal found 7/31![American Airlines logo]()
$313
One-way flights from San Francisco to Des MoinesSearch for one-way flight options from San Francisco to Des Moines. Find affordable one-way fares based on user searches. Data last updated August 1, 2026.
Search for one-way flight options from San Francisco to Des Moines. Find affordable one-way fares based on user searches. Data last updated August 1, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/34:00 pm
SFO
- DSM
1 stop19h 55m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/44:00 pm
SFO
- DSM
1 stop25h 34m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1011:17 am
SFO
- DSM
1 stop7h 49m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$107
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:25 am
SFO
- DSM
1 stop11h 09m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$109
This Priceline deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:00 am
SFO
- DSM
1 stop5h 34m
Frontier
Deal found 7/31![Frontier logo]()
$113
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2411:00 am
SFO
- DSM
1 stop6h 48m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/268:23 pm
SFO
- DSM
2 stops22h 37m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/151:10 pm
SFO
- DSM
1 stop23h 21m
Multiple Airlines
Deal found 7/31![Multiple Airlines logo]()
$127
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/114:31 pm
SFO
- DSM
2 stops40h 13m
Frontier
Deal found 7/30![Frontier logo]()
$128
Find flight deals from San Francisco to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 1, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $219 (Kiwi.com) |
One-way from | $98 (Kiwi.com) |
Popular in | January |
Cheapest in | February |
Average price | $502 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Francisco to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 1, 2026.
Use the filters below to find and compare flights from San Francisco to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Sat 10/31
5:10 am-1:05 pm
1 stop5h 55m
Des Moines
Tue 11/3
6:00 am-12:50 pm
1 stop8h 50m
$301
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Mon 8/17
7:00 am-9:15 pm
2 stops12h 15m
Des Moines
Sat 8/22
4:50 pm-9:25 pm
1 stop6h 35m
$362
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Thu 9/3
8:30 am-9:20 pm
2 stops10h 50m
Des Moines
Sun 9/6
7:05 am-2:10 pm
2 stops9h 05m
$366
Quickest round-trip
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Wed 10/28
12:08 pm-9:02 pm
1 stop6h 54m
Des Moines
Tue 11/3
6:55 am-10:52 am
1 stop5h 57m
$380
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Sun 10/4
11:55 am-9:30 pm
2 stops7h 35m
Des Moines
Sat 10/10
2:30 pm-9:35 pm
1 stop9h 05m
$400
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Wed 10/28
12:55 am-10:26 am
1 stop7h 31m
Des Moines
Tue 11/3
5:30 am-9:29 am
1 stop5h 59m
$401
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Sat 9/12
2:20 pm-11:33 pm
1 stop7h 13m
Des Moines
Sat 9/26
1:26 pm-7:32 pm
1 stop8h 06m
$401
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Wed 9/30
12:35 am-10:31 am
1 stop7h 56m
Des Moines
Sat 10/3
1:27 pm-7:34 pm
1 stop8h 07m
$401
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Mon 11/2
12:55 am-10:26 am
1 stop7h 31m
Des Moines
Tue 11/3
3:01 pm-9:38 pm
1 stop8h 37m
$401
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Fri 9/4
6:00 am-1:34 pm
1 stop5h 34m
Des Moines
Mon 9/7
2:19 pm-12:12 pm
1 stop23h 53m
$435
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from San Francisco to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Des Moines in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on San Francisco-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Francisco-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Francisco to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from San Francisco with our price prediction graph.
SFO-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Francisco to Des Moines
What is the cheapest month to book a flight from San Francisco to Des Moines?
Currently, February is the cheapest month in which you can book a flight from San Francisco to Des Moines (average of $280). Flying from San Francisco to Des Moines in January is currently the most expensive (average of $865). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from San Francisco to Des Moines?
Airfare is below average for this route at the moment.
San Francisco to Des Moines flights typically cost between $391 and $681 in October.The cheapest round-trip price found within the last 5 days was $219 on Multiple Airlines (Oct 13-Oct 18).
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated August 1, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from San Francisco to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Comfort
8.0
Food
7.0
Overall
8.0
Crew
8.6
Entertainment
7.5
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from San Francisco to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Ames
Clive
Johnston
Boone
West Des Moines
Ankeny
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Top 5 airlines flying from San Francisco to Des Moines
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| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$149 | Average$321 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$345 | Average$566 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$358 | Average$494 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$363 | Average$623 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$366 | Average$721 | FlexibilityNo cancel fee | On-time69% |