How long is the flight from San Francisco to Des Moines?

A quick flight from San Francisco to Des Moines can take about 8h 59m. United Airlines provides one of the quickest options available for as low as $385. San Francisco and Des Moines are separated by a distance of 1545 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

What are the cheapest airlines flying from San Francisco to Des Moines round-trip?

Frontier, at $149, was found to be the cheapest airline from San Francisco to Des Moines.Alternate airlines to your destination round-trip include Delta and American Airlines. Users have found that Frontier is 68% cheaper than the other options available to this destination.

What are the cheapest airlines to fly from San Francisco to Des Moines one-way?

For one-way options, check prices for Frontier. According to our data, you can fly for as low as $79. Users have also found prices from $156 and $156 on American Airlines and Delta, respectively.

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

What are the most popular airlines that fly from San Francisco to Des Moines?

When booking a flight from San Francisco to Des Moines, you may want to consider flying on American Airlines, United Airlines or Southwest as they are the most popular for this route.

Most accurate provider : When it comes to deals on San Francisco-Des Moines flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on San Francisco-Des Moines flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from San Francisco-Des Moines flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on San Francisco-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from San Francisco to Des Moines that include hotel bookings?

Yes. In addition to deals on San Francisco to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from San Francisco to Des Moines?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Des Moines.

Can I find deals for business class flights from San Francisco to Des Moines?

Yes. Cheapflights offers flight deals from San Francisco to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$91+ Flights from San Francisco to Des Moines

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Find cheap flights from San Francisco to Des Moines with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

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Cheapflights Tip: The best prices from San Francisco to Des Moines are usually found in September or January, booked 81 days in advance, depart on a Wednesday or Thursday and return on a Thursday

Cheap flight deals from San Francisco to Des Moines

Cheapest flights from San Francisco to Des Moines
Explore the most affordable flight options available from San Francisco to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 8, 2025.

Thu 12/186:00 amSFO - DSM

1 stop7h 31mMultiple Airlines

Mon 1/58:29 pmDSM - SFO

2 stops41h 25mMultiple Airlines

Deal found 12/8

$354

Mon 12/226:00 amSFO - DSM

1 stop11h 04mMultiple Airlines

Mon 1/58:29 pmDSM - SFO

2 stops41h 25mMultiple Airlines

Deal found 12/8

$387

Mon 12/86:30 amSFO - DSM

1 stop10h 33mFrontier

Fri 12/127:58 pmDSM - SFO

1 stop6h 26mFrontier

Deal found 12/6

$412

Fri 12/196:00 amSFO - DSM

1 stop11h 04mMultiple Airlines

Mon 1/58:29 pmDSM - SFO

2 stops41h 25mMultiple Airlines

Deal found 12/8

$419

Tue 12/238:12 pmSFO - DSM

1 stop12h 44mMultiple Airlines

Mon 1/58:29 pmDSM - SFO

2 stops41h 25mMultiple Airlines

Deal found 12/8

$422

Mon 12/296:24 amSFO - DSM

1 stop11h 20mFrontier

Fri 1/28:29 pmDSM - SFO

1 stop13h 54mFrontier

Deal found 12/8

$434

Thu 12/186:00 amSFO - DSM

1 stop7h 31mMultiple Airlines

Sun 1/411:50 amDSM - SFO

1 stop21h 58mMultiple Airlines

Deal found 12/8

$458

Mon 12/226:00 amSFO - DSM

1 stop11h 04mMultiple Airlines

Sun 1/411:50 amDSM - SFO

1 stop21h 58mMultiple Airlines

Deal found 12/8

$491

Best flights from San Francisco to Des Moines
Discover carefully curated flight deals from San Francisco to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 8, 2025.

Mon 1/196:25 amSFO - DSM

1 stop10h 58mMultiple Airlines

Thu 1/228:30 amDSM - SFO

1 stop9h 26mMultiple Airlines

Deal found 12/7

$259

Mon 1/1911:56 pmSFO - DSM

1 stop8h 59mUnited Airlines

Wed 1/215:30 amDSM - SFO

1 stop6h 15mUnited Airlines

Deal found 12/8

$385

Mon 1/199:10 amSFO - DSM

2 stops10h 10mSouthwest

Thu 1/228:35 amDSM - SFO

2 stops7h 45mSouthwest

Deal found 12/7

$430

Mon 1/56:00 amSFO - DSM

1 stop5h 57mAmerican Airlines

Thu 1/84:00 pmDSM - SFO

2 stops8h 40mAmerican Airlines

Deal found 12/8

$461

Mon 1/56:24 amSFO - DSM

1 stop11h 20mMultiple Airlines

Thu 1/87:00 amDSM - SFO

1 stop16h 19mMultiple Airlines

Deal found 12/7

$328

Mon 1/55:00 amSFO - DSM

2 stops8h 30mSouthwest

Thu 1/88:35 amDSM - SFO

2 stops10h 20mSouthwest

Deal found 12/7

$430

Mon 1/1911:15 amSFO - DSM

2 stops9h 00mSouthwest

Wed 1/218:35 amDSM - SFO

2 stops10h 20mSouthwest

Deal found 12/8

$432

Thu 1/85:00 amSFO - DSM

1 stop5h 52mUnited Airlines

Mon 1/123:04 pmDSM - SFO

1 stop10h 55mUnited Airlines

Deal found 12/6

$483

Thu 12/186:00 amSFO - DSM

1 stop7h 31mMultiple Airlines

Tue 12/302:35 pmDSM - SFO

2 stops26h 36mMultiple Airlines

Deal found 12/8

$513

Last-minute flights from San Francisco to Des Moines
Discover last-minute flight deals from San Francisco to Des Moines. Data last updated December 8, 2025 and is based on user searches.

Mon 12/86:30 amSFO - DSM

1 stop10h 33mFrontier

Fri 12/127:58 pmDSM - SFO

1 stop6h 26mFrontier

Deal found 12/7

$412

Thu 12/186:00 amSFO - DSM

1 stop7h 31mMultiple Airlines

Mon 1/58:29 pmDSM - SFO

2 stops41h 25mMultiple Airlines

Deal found 12/8

$354

Fri 12/196:00 amSFO - DSM

1 stop11h 04mMultiple Airlines

Mon 1/58:29 pmDSM - SFO

2 stops41h 25mMultiple Airlines

Deal found 12/8

$419

Mon 12/226:00 amSFO - DSM

1 stop11h 04mMultiple Airlines

Mon 1/58:29 pmDSM - SFO

2 stops41h 25mMultiple Airlines

Deal found 12/8

$387

Tue 12/238:12 pmSFO - DSM

1 stop12h 44mMultiple Airlines

Mon 1/58:29 pmDSM - SFO

2 stops41h 25mMultiple Airlines

Deal found 12/8

$422

Mon 1/56:24 amSFO - DSM

1 stop11h 20mMultiple Airlines

Thu 1/88:30 amDSM - SFO

2 stops27h 16mMultiple Airlines

Deal found 12/7

$309

Mon 1/196:25 amSFO - DSM

1 stop10h 58mMultiple Airlines

Thu 1/228:30 amDSM - SFO

1 stop9h 26mMultiple Airlines

Deal found 12/7

$259

Mon 1/196:25 amSFO - DSM

1 stop10h 58mMultiple Airlines

Wed 1/217:00 amDSM - SFO

2 stops18h 41mMultiple Airlines

Deal found 12/8

$278

Mon 1/1911:56 pmSFO - DSM

1 stop8h 59mUnited Airlines

Wed 1/215:30 amDSM - SFO

1 stop6h 15mUnited Airlines

Deal found 12/8

$385

One-way flights from San Francisco to Des Moines
Search for one-way flight options from San Francisco to Des Moines. Find affordable one-way fares based on user searches. Data last updated December 8, 2025.

Mon 1/128:58 amSFO - DSM

1 stop8h 24mFrontier

Deal found 12/8

$91

Thu 1/810:18 pmSFO - DSM

1 stop15h 22mMultiple Airlines

Deal found 12/7

$115

Tue 12/306:24 amSFO - DSM

1 stop5h 16mFrontier

Deal found 12/8

$142

Sat 1/177:00 amSFO - DSM

2 stops37h 09mMultiple Airlines

Deal found 12/8

$146

Thu 1/810:18 pmSFO - DSM

2 stops19h 04mFrontier

Deal found 12/7

$149

Sat 1/1712:17 amSFO - DSM

1 stop8h 33mAmerican Airlines

Deal found 12/7

$154

Mon 1/128:58 amSFO - DSM

2 stops54h 26mMultiple Airlines

Deal found 12/8

$155

Mon 12/296:24 amSFO - DSM

1 stop11h 20mFrontier

Deal found 12/8

$168

Wed 12/242:29 pmSFO - DSM

1 stop7h 29mUnited Airlines

Deal found 12/7

$190

Sat 12/279:30 pmSFO - DSM

2 stops36h 26mMultiple Airlines

Deal found 12/7

$233

Find flight deals from San Francisco to Des Moines

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$259 (Kiwi.com)
One-way from	$91 (Priceline)
Popular in	October
Cheapest in	September
Average price	$521

Provider with most accurate pricing for San Francisco-Des Moines flight deals.

Search Deals

Provider most trusted by Cheapflights users for San Francisco-Des Moines flights.

Search Deals

From San Francisco to Des Moines

Search Deals

One-way flight from San Francisco to Des Moines

Search Deals

Highest demand for flights based on searches. 3% potential increase in price ($15 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Francisco to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 1/19

6:25 am-7:23 pm

1 stop10h 58m

Des Moines

Thu 1/22

8:30 am-3:56 pm

1 stop9h 26m

$259

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 1/5

6:24 am-7:44 pm

1 stop11h 20m

Des Moines

Thu 1/8

7:00 am-9:19 pm

1 stop16h 19m

$328

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 1/19

11:56 pm-10:55 am

1 stop8h 59m

Des Moines

Wed 1/21

5:30 am-9:45 am

1 stop6h 15m

$385

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 1/19

9:10 am-9:20 pm

2 stops10h 10m

Des Moines

Thu 1/22

8:35 am-2:20 pm

2 stops7h 45m

$430

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 1/5

5:00 am-3:30 pm

2 stops8h 30m

Des Moines

Thu 1/8

8:35 am-4:55 pm

2 stops10h 20m

$430

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 1/19

11:15 am-10:15 pm

2 stops9h 00m

Des Moines

Wed 1/21

8:35 am-4:55 pm

2 stops10h 20m

$432

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 1/5

6:00 am-1:57 pm

1 stop5h 57m

Des Moines

Thu 1/8

4:00 pm-10:40 pm

2 stops8h 40m

$461

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 1/8

5:00 am-12:52 pm

1 stop5h 52m

Des Moines

Mon 1/12

3:04 pm-11:59 pm

1 stop10h 55m

$483

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Thu 12/18

6:00 am-3:31 pm

1 stop7h 31m

Des Moines

Tue 12/30

2:35 pm-3:11 pm

2 stops26h 36m

$513

San FranciscoDes Moines

SFO - DSM

SFODSM

San Francisco

Mon 1/12

8:58 am-7:22 pm

1 stop8h 24m

$91

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/8

Showing 1-10 of 18 results

Compare providers for flights from San Francisco to Des Moines

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Des Moines in December.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star
eDreams	Price Accuracy3 stars	Trust Score*3 stars
Priceline	Price Accuracy1 star	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on San Francisco-Des Moines flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on San Francisco-Des Moines flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from San Francisco-Des Moines flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on San Francisco-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from San Francisco to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from San Francisco with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Des Moines

How far ahead should I book a flight from San Francisco to Des Moines?

The best time to book flights from San Francisco to Des Moines is 81 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from San Francisco to Des Moines?

Currently, September is the cheapest month in which you can book a flight from San Francisco to Des Moines (average of $149). Flying from San Francisco to Des Moines in December is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SFO to DSM?

A simple way to save on the total cost of your ticket is to fly from San Francisco to Des Moines at noon. If you’re flexible enough to do this you can expect to save up to 23% on your trip compared to booking a flight in the morning.

What is the cheapest day to fly from San Francisco to Des Moines?

Travelers seeking maximum savings on their San Francisco to Des Moines flight should consider departing on Wednesday evenings when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Des Moines

Read reviews from past customers who have flown Southwest, Delta, and United Airlines from San Francisco to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,254 reviews

Reviews

1 / 20

10.0

Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.

Southwest

8.0

Very good

4,254 reviews

Southwest

8.0

Very good

4,254 reviews

Reviews

1 / 20

10.0

Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.

Delta

7.9

Good

8,011 reviews

Southwest

8.0

Very good

4,254 reviews

Reviews

1 / 20

10.0

Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.

United Airlines

7.4

Good

9,089 reviews

Southwest

8.0

Very good

4,254 reviews

Reviews

1 / 20

10.0

Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.

American Airlines

7.2

Good

11,045 reviews

Southwest

8.0

Very good

4,254 reviews

Reviews

1 / 20

10.0

Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.

Frontier

5.8

Fair

3,085 reviews

Southwest

8.0

Very good

4,254 reviews

Reviews

1 / 20

10.0

Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.

Related info for your journey

How long is the flight from San Francisco to Des Moines?
A quick flight from San Francisco to Des Moines can take about 8h 59m. United Airlines provides one of the quickest options available for as low as $385. San Francisco and Des Moines are separated by a distance of 1545 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What are the cheapest airlines flying from San Francisco to Des Moines round-trip?
Frontier, at $149, was found to be the cheapest airline from San Francisco to Des Moines.Alternate airlines to your destination round-trip include Delta and American Airlines. Users have found that Frontier is 68% cheaper than the other options available to this destination.
What are the cheapest airlines to fly from San Francisco to Des Moines one-way?
For one-way options, check prices for Frontier. According to our data, you can fly for as low as $79. Users have also found prices from $156 and $156 on American Airlines and Delta, respectively.
Can I find deals for flights from San Francisco to Des Moines that include hotel bookings?
Yes. In addition to deals on San Francisco to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from San Francisco to Des Moines?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Francisco to Des Moines.
Can I find deals for business class flights from San Francisco to Des Moines?
Yes. Cheapflights offers flight deals from San Francisco to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from San Francisco to Des Moines?
Currently, September is the cheapest month in which you can book a flight from San Francisco to Des Moines (average of $149). Flying from San Francisco to Des Moines in December is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Altoona

Johnston

Boone

Ames

Clive

West Des Moines

Ankeny

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Other flights to Des Moines

Top 5 airlines flying from San Francisco to Des Moines

Airline	Cheapest	Average	Flexibility	On-time
Frontier	Cheapest$149	Average$320	FlexibilityNo cancel fee	On-time62%
Delta	Cheapest$319	Average$448	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$334	Average$482	FlexibilityNo cancel fee	On-time71%
Southwest	Cheapest$346	Average$426	FlexibilityNo cancel fee	On-time63%
United Airlines	Cheapest$386	Average$520	FlexibilityNo cancel fee	On-time69%

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$91+ Cheap flights from San Francisco to Des Moines (SFO - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/12. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from San Francisco to Des Moines with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from San Francisco to Des Moines are usually found in September or January, booked 81 days in advance, depart on a Wednesday or Thursday and return on a Thursday

Cheap flight deals from San Francisco to Des Moines

Cheapest flights from San Francisco to Des MoinesExplore the most affordable flight options available from San Francisco to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 8, 2025.

Explore the most affordable flight options available from San Francisco to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 8, 2025.

Find flight deals from San Francisco to Des Moines

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Francisco to Des Moines that are best for you.

Compare providers for flights from San Francisco to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Des Moines in December.

Best time to book a flight from San Francisco to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from San Francisco with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from San Francisco to Des Moines

How far ahead should I book a flight from San Francisco to Des Moines?

What is the cheapest month to book a flight from San Francisco to Des Moines?

What is the cheapest time of day to fly from SFO to DSM?

What is the cheapest day to fly from San Francisco to Des Moines?

Reviews of airlines servicing Des Moines

Read reviews from past customers who have flown Southwest, Delta, and United Airlines from San Francisco to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from San Francisco to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from San Francisco to Des Moines?

What are the cheapest airlines flying from San Francisco to Des Moines round-trip?

What are the cheapest airlines to fly from San Francisco to Des Moines one-way?

Can I find deals for flights from San Francisco to Des Moines that include hotel bookings?

How can I find direct flights from San Francisco to Des Moines?

Can I find deals for business class flights from San Francisco to Des Moines?

What is the cheapest month to book a flight from San Francisco to Des Moines?

Traveling to a place near Des Moines?

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Alternative routes for San Francisco to Des Moines

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Top 5 airlines flying from San Francisco to Des Moines

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Cheapest flights from San Francisco to Des Moines
Explore the most affordable flight options available from San Francisco to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 8, 2025.