$101+ Cheap flights from San Francisco to Des Moines (SFO - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/13. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — DSM
Mar 7 — Mar 141
1 adult, Economy
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Find cheap flights from San Francisco to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Francisco to Des Moines
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Best
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One-way
Cheapest flights from San Francisco to Des MoinesExplore the most affordable flight options available from San Francisco to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 5, 2026.
Explore the most affordable flight options available from San Francisco to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 5, 2026.
This CheapOair deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/198:48 am
SFO
- DSM
1 stop7h 59m
Frontier
Mon 2/237:17 pm
DSM
- SFO
1 stop28h 44m
Frontier
Deal found 2/2![Frontier logo]()
$190
This Frontier deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/146:00 am
SFO
- DSM
1 stop11h 16m
Frontier
Wed 3/188:21 pm
DSM
- SFO
1 stop6h 07m
Frontier
Deal found 2/4![Frontier logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/159:04 pm
SFO
- DSM
1 stop20h 12m
Frontier
Wed 3/188:21 pm
DSM
- SFO
1 stop25h 48m
Frontier
Deal found 2/4![Frontier logo]()
$279
This Frontier deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:00 am
SFO
- DSM
1 stop11h 16m
Frontier
Wed 3/188:21 pm
DSM
- SFO
1 stop6h 07m
Frontier
Deal found 2/4![Frontier logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/47:15 pm
SFO
- DSM
2 stops21h 27m
Multiple Airlines
Wed 3/119:00 am
DSM
- SFO
1 stop24h 58m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$317
This Priceline deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/128:48 am
SFO
- DSM
1 stop7h 59m
Frontier
Sun 2/157:27 pm
DSM
- SFO
1 stop7h 01m
Frontier
Deal found 2/3![Frontier logo]()
$321
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/226:41 pm
SFO
- DSM
2 stops22h 35m
Frontier
Mon 3/308:21 pm
DSM
- SFO
1 stop25h 48m
Frontier
Deal found 2/2![Frontier logo]()
$353
Best flights from San Francisco to Des MoinesDiscover carefully curated flight deals from San Francisco to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 5, 2026.
Discover carefully curated flight deals from San Francisco to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 5, 2026.
This CheapOair deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/198:48 am
SFO
- DSM
1 stop7h 59m
Frontier
Mon 2/237:17 pm
DSM
- SFO
1 stop28h 44m
Frontier
Deal found 2/3![Frontier logo]()
$201
This American Airlines deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/315:34 pm
SFO
- DSM
1 stop13h 15m
American Airlines
Tue 4/76:00 am
DSM
- SFO
1 stop13h 58m
American Airlines
Deal found 2/5![American Airlines logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/149:04 pm
SFO
- DSM
2 stops21h 12m
Multiple Airlines
Wed 3/188:21 pm
DSM
- SFO
1 stop25h 48m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$376
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/3110:10 am
SFO
- DSM
2 stops11h 32m
United Airlines
Tue 4/75:30 am
DSM
- SFO
2 stops13h 42m
United Airlines
Deal found 2/2![United Airlines logo]()
$401
This Frontier deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/146:00 am
SFO
- DSM
1 stop11h 16m
Frontier
Wed 3/188:21 pm
DSM
- SFO
1 stop6h 07m
Frontier
Deal found 2/4![Frontier logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/159:04 pm
SFO
- DSM
1 stop20h 12m
Frontier
Wed 3/188:21 pm
DSM
- SFO
1 stop25h 48m
Frontier
Deal found 2/4![Frontier logo]()
$279
This United Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/45:10 am
SFO
- DSM
1 stop5h 40m
United Airlines
Wed 3/116:49 pm
DSM
- SFO
1 stop7h 27m
United Airlines
Deal found 2/4![United Airlines logo]()
$412
This Frontier deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/156:15 am
SFO
- DSM
1 stop10h 17m
Frontier
Thu 2/197:32 pm
DSM
- SFO
1 stop6h 56m
Frontier
Deal found 2/3![Frontier logo]()
$420
Last-minute flights from San Francisco to Des MoinesDiscover last-minute flight deals from San Francisco to Des Moines. Data last updated February 5, 2026 and is based on user searches.
Discover last-minute flight deals from San Francisco to Des Moines. Data last updated February 5, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 2/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/126:15 am
SFO
- DSM
1 stop10h 32m
Frontier
Sun 2/157:27 pm
DSM
- SFO
1 stop7h 01m
Frontier
Deal found 2/5![Frontier logo]()
$321
This CheapOair deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/198:48 am
SFO
- DSM
1 stop7h 59m
Frontier
Mon 2/237:17 pm
DSM
- SFO
1 stop28h 44m
Frontier
Deal found 2/2![Frontier logo]()
$190
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/47:15 pm
SFO
- DSM
2 stops21h 27m
Multiple Airlines
Wed 3/119:00 am
DSM
- SFO
1 stop24h 58m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$317
This Frontier deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:00 am
SFO
- DSM
1 stop11h 16m
Frontier
Wed 3/188:21 pm
DSM
- SFO
1 stop6h 07m
Frontier
Deal found 2/4![Frontier logo]()
$305
This Frontier deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/146:00 am
SFO
- DSM
1 stop11h 16m
Frontier
Wed 3/188:21 pm
DSM
- SFO
1 stop6h 07m
Frontier
Deal found 2/4![Frontier logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/159:04 pm
SFO
- DSM
1 stop20h 12m
Frontier
Wed 3/188:21 pm
DSM
- SFO
1 stop25h 48m
Frontier
Deal found 2/4![Frontier logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/226:41 pm
SFO
- DSM
2 stops22h 35m
Frontier
Mon 3/308:21 pm
DSM
- SFO
1 stop25h 48m
Frontier
Deal found 2/2![Frontier logo]()
$353
One-way flights from San Francisco to Des MoinesSearch for one-way flight options from San Francisco to Des Moines. Find affordable one-way fares based on user searches. Data last updated February 5, 2026.
Search for one-way flight options from San Francisco to Des Moines. Find affordable one-way fares based on user searches. Data last updated February 5, 2026.
This Frontier deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/136:00 am
SFO
- DSM
1 stop11h 14m
Frontier
Deal found 2/3![Frontier logo]()
$101
This Priceline deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/238:48 am
SFO
- DSM
1 stop7h 44m
Frontier
Deal found 2/3![Frontier logo]()
$116
This CheapOair deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1411:51 am
SFO
- DSM
1 stop23h 38m
Frontier
Deal found 2/1![Frontier logo]()
$163
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/102:01 pm
SFO
- DSM
2 stops21h 28m
Frontier
Deal found 2/4![Frontier logo]()
$175
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/257:15 pm
SFO
- DSM
2 stops21h 27m
Frontier
Deal found 2/4![Frontier logo]()
$179
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1410:03 am
SFO
- DSM
2 stops23h 58m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$187
This American Airlines deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/2412:30 am
SFO
- DSM
1 stop8h 04m
American Airlines
Deal found 2/4![American Airlines logo]()
$189
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:48 am
SFO
- DSM
1 stop7h 44m
Frontier
Deal found 2/4![Frontier logo]()
$191
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/287:08 pm
SFO
- DSM
3 stops17h 10m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$203
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/109:33 pm
SFO
- DSM
1 stop23h 14m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/257:20 am
SFO
- DSM
3 stops37h 46m
Multiple Airlines
Deal found 2/4![Multiple Airlines logo]()
$215
Find flight deals from San Francisco to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $190 (CheapOair) |
One-way from | $101 (Frontier) |
Popular in | January |
Cheapest in | September |
Average price | $513 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Francisco to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 5, 2026.
Use the filters below to find and compare flights from San Francisco to Des Moines that are best for you.
Fly from
San Francisco
Fly to
Des Moines
Route
Depart
Return
Price
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Thu 2/19
8:48 am-6:47 pm
1 stop7h 59m
Des Moines
Mon 2/23
7:17 pm-10:01 pm
1 stop28h 44m
$201
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Sat 3/14
6:00 am-7:16 pm
1 stop11h 16m
Des Moines
Wed 3/18
8:21 pm-12:28 am
1 stop6h 07m
$254
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Sun 3/15
9:04 pm-7:16 pm
1 stop20h 12m
Des Moines
Wed 3/18
8:21 pm-8:09 pm
1 stop25h 48m
$279
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Tue 3/31
5:34 pm-8:49 am
1 stop13h 15m
Des Moines
Tue 4/7
6:00 am-5:58 pm
1 stop13h 58m
$363
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Sat 3/14
9:04 pm-8:16 pm
2 stops21h 12m
Des Moines
Wed 3/18
8:21 pm-8:09 pm
1 stop25h 48m
$376
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Tue 3/31
10:10 am-11:42 pm
2 stops11h 32m
Des Moines
Tue 4/7
5:30 am-5:12 pm
2 stops13h 42m
$401
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Wed 3/4
5:10 am-12:50 pm
1 stop5h 40m
Des Moines
Wed 3/11
6:49 pm-12:16 am
1 stop7h 27m
$412
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Sun 2/15
6:15 am-6:32 pm
1 stop10h 17m
Des Moines
Thu 2/19
7:32 pm-12:28 am
1 stop6h 56m
$420
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Mon 4/13
6:00 am-7:14 pm
1 stop11h 14m
$101
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Mon 2/23
8:48 am-6:32 pm
1 stop7h 44m
$116
Showing 1-10 of 18 results
Compare providers for flights from San Francisco to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Des Moines in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on San Francisco-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Francisco-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Francisco to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from San Francisco with our price prediction graph.
SFO-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Francisco to Des Moines
How far ahead should I book a flight from San Francisco to Des Moines?
Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Des Moines. Price data was last updated on January 30, 2026.
The best time to book flights from San Francisco to Des Moines is 81 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from San Francisco to Des Moines?
Currently, September is the cheapest month in which you can book a flight from San Francisco to Des Moines (average of $149). Flying from San Francisco to Des Moines in January is currently the most expensive (average of $368). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated February 5, 2026.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from San Francisco to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Comfort
8.0
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Comfort
8.0
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Comfort
8.0
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Comfort
8.0
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Comfort
8.0
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Related info for your journey
Find useful and relevant information for your journey from San Francisco to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny
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Find flights from San Francisco to Des Moines, based on your preferred cabin class, be it economy, premium economy, business, or first class.
San Francisco and Des Moines flights
Browse other San Francisco and Des Moines flight options. Last updated on February 5, 2026.
Other flights from San Francisco
Browse through other flights departing from San Francisco. Flights are based on user searches made on Cheapflights and were last updated on February 5, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 5 airlines flying from San Francisco to Des Moines
Discover the top 5 airlines that operate flights from San Francisco to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$149 | Average$330 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$263 | Average$452 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$329 | Average$491 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$346 | Average$426 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$386 | Average$521 | FlexibilityNo cancel fee | On-time69% |