$93+ Cheap flights from San Francisco to Des Moines (SFO - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/18. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — DSM
Apr 7 — Apr 141
Round-trip
1 adult, Economy
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Cheapest flights from San Francisco to Des MoinesExplore the most affordable flight options available from San Francisco to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 8, 2026.
Explore the most affordable flight options available from San Francisco to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:43 am
SFO
- DSM
1 stop10h 01m
Multiple Airlines
Sun 5/3110:26 pm
DSM
- SFO
1 stop17h 03m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$229
This Frontier deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:00 am
SFO
- DSM
1 stop11h 38m
Frontier
Fri 5/82:20 pm
DSM
- SFO
1 stop12h 02m
Frontier
Deal found 3/3![Frontier logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:43 am
SFO
- DSM
1 stop10h 01m
Multiple Airlines
Mon 6/19:17 pm
DSM
- SFO
1 stop18h 12m
Multiple Airlines
Deal found 3/3![Multiple Airlines logo]()
$258
This Frontier deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:00 am
SFO
- DSM
1 stop11h 14m
Frontier
Mon 4/138:14 pm
DSM
- SFO
1 stop6h 14m
Frontier
Deal found 3/3![Frontier logo]()
$260
This Frontier deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/186:00 am
SFO
- DSM
1 stop11h 16m
Frontier
Sat 3/212:56 pm
DSM
- SFO
1 stop6h 34m
Frontier
Deal found 3/3![Frontier logo]()
$290
This Expedia deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/146:00 am
SFO
- DSM
1 stop11h 16m
Frontier
Sat 3/218:21 pm
DSM
- SFO
1 stop6h 07m
Frontier
Deal found 3/6![Frontier logo]()
$295
This Frontier deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/116:00 am
SFO
- DSM
1 stop11h 16m
Frontier
Wed 3/188:21 pm
DSM
- SFO
1 stop6h 07m
Frontier
Deal found 3/7![Frontier logo]()
$296
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/128:43 am
SFO
- DSM
1 stop10h 23m
Multiple Airlines
Mon 6/159:56 pm
DSM
- SFO
1 stop17h 33m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$302
This CheapOair deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/129:04 pm
SFO
- DSM
1 stop20h 12m
Frontier
Wed 3/188:21 pm
DSM
- SFO
1 stop6h 07m
Frontier
Deal found 3/7![Frontier logo]()
$307
This Frontier deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:00 am
SFO
- DSM
1 stop11h 14m
Frontier
Fri 4/108:14 pm
DSM
- SFO
1 stop6h 14m
Frontier
Deal found 3/3![Frontier logo]()
$310
Best flights from San Francisco to Des MoinesDiscover carefully curated flight deals from San Francisco to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 8, 2026.
Discover carefully curated flight deals from San Francisco to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 8, 2026.
This United Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:00 am
SFO
- DSM
1 stop5h 47m
United Airlines
Tue 4/215:12 pm
DSM
- SFO
1 stop7h 43m
United Airlines
Deal found 3/7![United Airlines logo]()
$379
This Delta deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/2512:10 am
SFO
- DSM
1 stop7h 59m
Delta
Wed 4/84:25 pm
DSM
- SFO
1 stop6h 34m
Delta
Deal found 3/3![Delta logo]()
$387
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/208:05 am
SFO
- DSM
2 stops8h 30m
Southwest
Wed 4/223:15 pm
DSM
- SFO
2 stops10h 00m
Southwest
Deal found 3/4![Southwest logo]()
$387
This United Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/78:20 am
SFO
- DSM
1 stop5h 50m
United Airlines
Sat 4/115:30 am
DSM
- SFO
1 stop6h 00m
United Airlines
Deal found 3/7![United Airlines logo]()
$379
This Delta deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:08 am
SFO
- DSM
1 stop7h 33m
Delta
Tue 5/54:23 pm
DSM
- SFO
1 stop6h 28m
Delta
Deal found 3/3![Delta logo]()
$387
This Southwest deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2411:10 am
SFO
- DSM
2 stops8h 45m
Southwest
Mon 4/277:10 pm
DSM
- SFO
1 stop5h 55m
Southwest
Deal found 3/6![Southwest logo]()
$418
This Delta deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/411:59 pm
SFO
- DSM
1 stop8h 17m
Delta
Sat 5/94:15 pm
DSM
- SFO
1 stop6h 22m
Delta
Deal found 3/3![Delta logo]()
$398
This Southwest deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/77:20 am
SFO
- DSM
2 stops8h 35m
Southwest
Sat 4/1112:05 pm
DSM
- SFO
2 stops7h 20m
Southwest
Deal found 3/7![Southwest logo]()
$452
This United Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/195:00 am
SFO
- DSM
1 stop5h 47m
United Airlines
Wed 4/225:30 am
DSM
- SFO
1 stop6h 00m
United Airlines
Deal found 3/3![United Airlines logo]()
$457
This Southwest deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/110:10 am
SFO
- DSM
2 stops9h 45m
Southwest
Sun 5/34:20 pm
DSM
- SFO
1 stop9h 50m
Southwest
Deal found 3/4![Southwest logo]()
$452
This Southwest deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/278:55 am
SFO
- DSM
1 stop7h 00m
Southwest
Sat 5/302:10 pm
DSM
- SFO
2 stops9h 10m
Southwest
Deal found 3/5![Southwest logo]()
$452
This Southwest deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2810:30 am
SFO
- DSM
2 stops9h 25m
Southwest
Sun 5/314:20 pm
DSM
- SFO
2 stops10h 00m
Southwest
Deal found 3/5![Southwest logo]()
$457
Last-minute flights from San Francisco to Des MoinesDiscover last-minute flight deals from San Francisco to Des Moines. Data last updated March 8, 2026 and is based on user searches.
Discover last-minute flight deals from San Francisco to Des Moines. Data last updated March 8, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/76:00 am
SFO
- DSM
1 stop11h 16m
Frontier
Sat 3/288:21 pm
DSM
- SFO
1 stop6h 07m
Frontier
Deal found 3/3![Frontier logo]()
$345
This Frontier deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/96:00 am
SFO
- DSM
1 stop11h 16m
Frontier
Wed 3/118:21 pm
DSM
- SFO
1 stop6h 07m
Frontier
Deal found 3/6![Frontier logo]()
$360
This Frontier deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/116:00 am
SFO
- DSM
1 stop11h 16m
Frontier
Wed 3/188:21 pm
DSM
- SFO
1 stop6h 07m
Frontier
Deal found 3/7![Frontier logo]()
$296
This CheapOair deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/129:04 pm
SFO
- DSM
1 stop20h 12m
Frontier
Wed 3/188:21 pm
DSM
- SFO
1 stop6h 07m
Frontier
Deal found 3/7![Frontier logo]()
$307
This Expedia deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/146:00 am
SFO
- DSM
1 stop11h 16m
Frontier
Sat 3/218:21 pm
DSM
- SFO
1 stop6h 07m
Frontier
Deal found 3/6![Frontier logo]()
$295
This Frontier deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/186:00 am
SFO
- DSM
1 stop11h 16m
Frontier
Sat 3/212:56 pm
DSM
- SFO
1 stop6h 34m
Frontier
Deal found 3/3![Frontier logo]()
$290
This Southwest deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/315:55 am
SFO
- DSM
1 stop5h 20m
Southwest
Tue 4/76:55 am
DSM
- SFO
1 stop5h 45m
Southwest
Deal found 3/3![Southwest logo]()
$357
This Frontier deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:00 am
SFO
- DSM
1 stop11h 14m
Frontier
Fri 4/108:14 pm
DSM
- SFO
1 stop6h 14m
Frontier
Deal found 3/3![Frontier logo]()
$310
This American Airlines deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/77:00 am
SFO
- DSM
1 stop9h 25m
American Airlines
Sat 5/237:02 pm
DSM
- SFO
1 stop7h 46m
American Airlines
Deal found 3/6![American Airlines logo]()
$322
This Frontier deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:00 am
SFO
- DSM
1 stop11h 14m
Frontier
Mon 4/138:14 pm
DSM
- SFO
1 stop6h 14m
Frontier
Deal found 3/3![Frontier logo]()
$260
One-way flights from San Francisco to Des MoinesSearch for one-way flight options from San Francisco to Des Moines. Find affordable one-way fares based on user searches. Data last updated March 8, 2026.
Search for one-way flight options from San Francisco to Des Moines. Find affordable one-way fares based on user searches. Data last updated March 8, 2026.
This Trip.com deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/186:00 am
SFO
- DSM
1 stop11h 16m
Frontier
Deal found 3/3![Frontier logo]()
$93
This Frontier deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/136:00 am
SFO
- DSM
1 stop11h 14m
Frontier
Deal found 3/3![Frontier logo]()
$101
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/48:43 am
SFO
- DSM
1 stop9h 28m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$110
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/219:00 pm
SFO
- DSM
1 stop13h 59m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/74:00 pm
SFO
- DSM
2 stops28h 32m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$136
This Kiwi.com deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/169:58 pm
SFO
- DSM
1 stop15h 04m
Multiple Airlines
Deal found 3/6![Multiple Airlines logo]()
$138
This Expedia deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/256:00 am
SFO
- DSM
1 stop11h 16m
Frontier
Deal found 3/3![Frontier logo]()
$151
This Kiwi.com deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3110:24 pm
SFO
- DSM
2 stops22h 24m
Multiple Airlines
Deal found 3/5![Multiple Airlines logo]()
$163
This Expedia deal was found by Cheapflights users on 3/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/139:04 pm
SFO
- DSM
1 stop20h 12m
Frontier
Deal found 3/5![Frontier logo]()
$166
This Frontier deal was found by Cheapflights users on 3/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/206:00 am
SFO
- DSM
1 stop11h 26m
Frontier
Deal found 3/6![Frontier logo]()
$170
This Expedia deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/306:00 am
SFO
- DSM
1 stop11h 16m
Frontier
Deal found 3/3![Frontier logo]()
$171
Find flight deals from San Francisco to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 8, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $229 (Kiwi.com) |
One-way from | $93 (Trip.com) |
Popular in | January |
Cheapest in | February |
Average price | $613 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Francisco to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 8, 2026.
Use the filters below to find and compare flights from San Francisco to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Wed 4/15
5:00 am-12:47 pm
1 stop5h 47m
Des Moines
Tue 4/21
5:12 pm-10:55 pm
1 stop7h 43m
$379
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Tue 4/7
8:20 am-4:10 pm
1 stop5h 50m
Des Moines
Sat 4/11
5:30 am-9:30 am
1 stop6h 00m
$379
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Wed 3/25
12:10 am-10:09 am
1 stop7h 59m
Des Moines
Wed 4/8
4:25 pm-8:59 pm
1 stop6h 34m
$387
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Mon 4/20
8:05 am-6:35 pm
2 stops8h 30m
Des Moines
Wed 4/22
3:15 pm-11:15 pm
2 stops10h 00m
$387
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Sat 5/2
6:08 am-3:41 pm
1 stop7h 33m
Des Moines
Tue 5/5
4:23 pm-8:51 pm
1 stop6h 28m
$387
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Mon 5/4
11:59 pm-10:16 am
1 stop8h 17m
Des Moines
Sat 5/9
4:15 pm-8:37 pm
1 stop6h 22m
$398
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Fri 4/24
11:10 am-9:55 pm
2 stops8h 45m
Des Moines
Mon 4/27
7:10 pm-11:05 pm
1 stop5h 55m
$418
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Tue 4/7
7:20 am-5:55 pm
2 stops8h 35m
Des Moines
Sat 4/11
12:05 pm-5:25 pm
2 stops7h 20m
$452
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Fri 5/1
10:10 am-9:55 pm
2 stops9h 45m
Des Moines
Sun 5/3
4:20 pm-12:10 am
1 stop9h 50m
$452
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Wed 5/27
8:55 am-5:55 pm
1 stop7h 00m
Des Moines
Sat 5/30
2:10 pm-9:20 pm
2 stops9h 10m
$452
Showing 1-10 of 22 resultsSorted by cheapest first
Compare providers for flights from San Francisco to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Des Moines in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on San Francisco-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Francisco-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Francisco to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from San Francisco with our price prediction graph.
SFO-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Francisco to Des Moines
How far ahead should I book a flight from San Francisco to Des Moines?
Use this chart to determine the optimal time to book a round-trip flight from San Francisco to Des Moines. Price data was last updated on March 6, 2026.
The best time to book flights from San Francisco to Des Moines is 81 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from San Francisco to Des Moines?
Currently, September is the cheapest month in which you can book a flight from San Francisco to Des Moines (average of $149). Flying from San Francisco to Des Moines in March is currently the most expensive (average of $370). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated March 8, 2026.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from San Francisco to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Overall
8.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Overall
8.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Overall
8.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Overall
8.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Overall
8.0
Entertainment
7.5
Boarding
8.1
Comfort
8.0
Crew
8.6
Food
7.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Related info for your journey
Find useful and relevant information for your journey from San Francisco to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Johnston
Ankeny
Ames
Boone
Clive
West Des Moines
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Top 5 airlines flying from San Francisco to Des Moines
Discover the top 5 airlines that operate flights from San Francisco to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$149 | Average$285 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$263 | Average$449 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$334 | Average$482 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$346 | Average$426 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$366 | Average$492 | FlexibilityNo cancel fee | On-time69% |