$106+ Cheap flights from San Francisco to Des Moines (SFO - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/16. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — DSM
Sep 10 — Sep 171
Round-trip
1 adult, Economy
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Find cheap flights from San Francisco to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Francisco to Des Moines
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Cheapest flights from San Francisco to Des MoinesExplore the most affordable flight options available from San Francisco to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 11, 2026.
Explore the most affordable flight options available from San Francisco to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 11, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/118:34 am -
1 stop8h 59m
Mon 9/149:31 pm -
1 stop12h 43m
Deal found 8/10![Multiple Airlines logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/251:10 pm -
1 stop23h 21m
Mon 9/289:31 pm -
1 stop22h 53m
Deal found 8/8![Multiple Airlines logo]()
$220
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/110:24 pm -
1 stop10h 33m
Mon 10/51:02 pm -
1 stop21h 12m
Deal found 8/8![Multiple Airlines logo]()
$227
This Expedia deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:04 am -
1 stop11h 29m
Mon 10/192:31 pm -
1 stop11h 44m
Deal found 8/7![Frontier logo]()
$244
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:04 am -
1 stop11h 29m
Mon 9/148:30 pm -
2 stops15h 52m
Deal found 8/10![Frontier logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/171:10 pm -
2 stops28h 23m
Mon 9/218:30 pm -
1 stop16h 17m
Deal found 8/11![Frontier logo]()
$266
Best flights from San Francisco to Des MoinesDiscover carefully curated flight deals from San Francisco to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 11, 2026.
Discover carefully curated flight deals from San Francisco to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 11, 2026.
This United Airlines deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:00 am -
1 stop5h 32m
Wed 9/235:45 am -
1 stop5h 41m
Deal found 8/11![United Airlines logo]()
$305
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/228:40 am -
2 stops10h 25m
Tue 9/297:15 am -
2 stops8h 50m
Deal found 8/11![Southwest logo]()
$315
This American Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/812:23 pm -
1 stop6h 23m
Tue 9/152:17 pm -
1 stop6h 54m
Deal found 8/9![American Airlines logo]()
$477
This Delta deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:10 am -
1 stop8h 01m
Mon 11/24:01 pm -
2 stops9h 55m
Deal found 8/7![Delta logo]()
$478
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:00 am -
1 stop7h 15m
Mon 11/25:12 pm -
1 stop7h 57m
Deal found 8/7![United Airlines logo]()
$425
This Southwest deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/212:15 pm -
1 stop5h 30m
Fri 11/2712:10 pm -
1 stop7h 10m
Deal found 8/11![Southwest logo]()
$477
This Southwest deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1710:25 am -
2 stops8h 55m
Thu 10/12:00 pm -
2 stops9h 05m
Deal found 8/9![Southwest logo]()
$487
This Southwest deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/288:30 am -
2 stops10h 50m
Wed 9/307:15 am -
2 stops7h 20m
Deal found 8/9![Southwest logo]()
$487
This Southwest deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/110:45 am -
2 stops9h 10m
Mon 10/511:50 am -
2 stops8h 55m
Deal found 8/8![Southwest logo]()
$487
This Southwest deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/211:30 am -
2 stops8h 25m
Sun 10/46:45 am -
2 stops9h 00m
Deal found 8/10![Southwest logo]()
$497
Last-minute flights from San Francisco to Des MoinesDiscover last-minute flight deals from San Francisco to Des Moines. Data last updated August 11, 2026 and is based on user searches.
Discover last-minute flight deals from San Francisco to Des Moines. Data last updated August 11, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/118:34 am -
1 stop8h 59m
Mon 9/149:31 pm -
1 stop12h 43m
Deal found 8/10![Multiple Airlines logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:04 am -
1 stop11h 29m
Mon 9/148:30 pm -
2 stops15h 52m
Deal found 8/10![Frontier logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/171:10 pm -
2 stops28h 23m
Mon 9/218:30 pm -
1 stop16h 17m
Deal found 8/11![Frontier logo]()
$266
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1711:17 am -
1 stop7h 49m
Fri 9/188:38 pm -
1 stop19h 51m
Deal found 8/7![Multiple Airlines logo]()
$293
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/227:00 am -
1 stop8h 36m
Thu 9/247:40 pm -
1 stop6h 40m
Deal found 8/10![American Airlines logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/251:10 pm -
1 stop23h 21m
Mon 9/289:31 pm -
1 stop22h 53m
Deal found 8/8![Multiple Airlines logo]()
$220
This CheapOair deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2511:42 am -
1 stop5h 51m
Thu 10/111:29 am -
1 stop14h 45m
Deal found 8/7![Frontier logo]()
$272
This CheapOair deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/2511:42 am -
1 stop5h 51m
Sun 9/2711:29 am -
1 stop25h 18m
Deal found 8/7![Frontier logo]()
$300
One-way flights from San Francisco to Des MoinesSearch for one-way flight options from San Francisco to Des Moines. Find affordable one-way fares based on user searches. Data last updated August 11, 2026.
Search for one-way flight options from San Francisco to Des Moines. Find affordable one-way fares based on user searches. Data last updated August 11, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/167:11 pm -
1 stop23h 55m
Deal found 8/9![Multiple Airlines logo]()
$106
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1011:17 am -
1 stop7h 49m
Deal found 8/7![Multiple Airlines logo]()
$111
This CheapOair deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:04 am -
1 stop26h 40m
Deal found 8/11![Frontier logo]()
$114
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/34:00 pm -
1 stop19h 55m
Deal found 8/10![Multiple Airlines logo]()
$115
This Kiwi.com deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/151:10 pm -
1 stop23h 21m
Deal found 8/10![Multiple Airlines logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/33:38 pm -
1 stop17h 32m
Deal found 8/9![Multiple Airlines logo]()
$130
This Southwest deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1111:40 pm -
1 stop9h 50m
Deal found 8/9![Southwest logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1012:07 pm -
2 stops29h 26m
Deal found 8/7![Frontier logo]()
$132
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1711:17 am -
1 stop7h 49m
Deal found 8/9![Multiple Airlines logo]()
$144
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1110:24 pm -
2 stops34h 20m
Deal found 8/9![Frontier logo]()
$146
Find flight deals from San Francisco to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $214 (Kiwi.com) |
One-way from | $106 (Kiwi.com) |
Popular in | January |
Cheapest in | February |
Average price | $502 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Francisco to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 11, 2026.
Use the filters below to find and compare flights from San Francisco to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
San FranciscoDes Moines
SFO San Francisco - DSM Des Moines
SFODSM
San Francisco
Wed 9/16
5:00 am-12:32 pm
1 stop5h 32m
Des Moines
Wed 9/23
5:45 am-9:26 am
1 stop5h 41m
$305
San FranciscoDes Moines
SFO San Francisco - DSM Des Moines
SFODSM
San Francisco
Tue 9/22
8:40 am-9:05 pm
2 stops10h 25m
Des Moines
Tue 9/29
7:15 am-2:05 pm
2 stops8h 50m
$315
San FranciscoDes Moines
SFO San Francisco - DSM Des Moines
SFODSM
San Francisco
Sat 10/24
5:00 am-2:15 pm
1 stop7h 15m
Des Moines
Mon 11/2
5:12 pm-11:09 pm
1 stop7h 57m
$425
San FranciscoDes Moines
SFO San Francisco - DSM Des Moines
SFODSM
San Francisco
Tue 9/8
12:23 pm-8:46 pm
1 stop6h 23m
Des Moines
Tue 9/15
2:17 pm-7:11 pm
1 stop6h 54m
$477
San FranciscoDes Moines
SFO San Francisco - DSM Des Moines
SFODSM
San Francisco
Sat 11/21
2:15 pm-9:45 pm
1 stop5h 30m
Des Moines
Fri 11/27
12:10 pm-5:20 pm
1 stop7h 10m
$477
San FranciscoDes Moines
SFO San Francisco - DSM Des Moines
SFODSM
San Francisco
Fri 10/23
12:10 am-10:11 am
1 stop8h 01m
Des Moines
Mon 11/2
4:01 pm-11:56 pm
2 stops9h 55m
$478
San FranciscoDes Moines
SFO San Francisco - DSM Des Moines
SFODSM
San Francisco
Thu 9/17
10:25 am-9:20 pm
2 stops8h 55m
Des Moines
Thu 10/1
2:00 pm-9:05 pm
2 stops9h 05m
$487
San FranciscoDes Moines
SFO San Francisco - DSM Des Moines
SFODSM
San Francisco
Mon 9/28
8:30 am-9:20 pm
2 stops10h 50m
Des Moines
Wed 9/30
7:15 am-12:35 pm
2 stops7h 20m
$487
San FranciscoDes Moines
SFO San Francisco - DSM Des Moines
SFODSM
San Francisco
Thu 10/1
10:45 am-9:55 pm
2 stops9h 10m
Des Moines
Mon 10/5
11:50 am-6:45 pm
2 stops8h 55m
$487
San FranciscoDes Moines
SFO San Francisco - DSM Des Moines
SFODSM
San Francisco
Fri 10/2
11:30 am-9:55 pm
2 stops8h 25m
Des Moines
Sun 10/4
6:45 am-1:45 pm
2 stops9h 00m
$497
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from San Francisco to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Des Moines in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on San Francisco-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Francisco-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Francisco to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from San Francisco with our price prediction graph.
SFO-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Francisco to Des Moines
What is the cheapest month to book a flight from San Francisco to Des Moines?
Currently, February is the cheapest month in which you can book a flight from San Francisco to Des Moines (average of $280). Flying from San Francisco to Des Moines in January is currently the most expensive (average of $865). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from San Francisco to Des Moines?
Airfare is below average for this route at the moment.
San Francisco to Des Moines flights typically cost between $400 and $875 in September.The cheapest round-trip price found within the last 5 days was $214 on Multiple Airlines (Sep 11-Sep 14).
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated August 11, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from San Francisco to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Crew
8.6
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Crew
8.6
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Crew
8.6
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Crew
8.6
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Crew
8.6
Boarding
8.1
Food
7.0
Comfort
8.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from San Francisco to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
Ames
Johnston
Boone
Norwalk
West Des Moines
Ankeny
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Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on August 11, 2026.
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San Francisco and Des Moines flights
Browse other San Francisco and Des Moines flight options. Last updated on August 11, 2026.
Other flights from San Francisco
Browse through other flights departing from San Francisco. Flights are based on user searches made on Cheapflights and were last updated on August 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 5 airlines flying from San Francisco to Des Moines
Discover the top 5 airlines that operate flights from San Francisco to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$173 | Average$321 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$347 | Average$566 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$358 | Average$494 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$363 | Average$668 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$366 | Average$721 | FlexibilityNo cancel fee | On-time69% |