$105+ Cheap flights from San Francisco to Des Moines (SFO - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/27. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — DSM
May 30 — Jun 61
Round-trip
1 adult, Economy
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Find cheap flights from San Francisco to Des Moines with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Francisco to Des Moines
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Best
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One-way
Cheapest flights from San Francisco to Des MoinesExplore the most affordable flight options available from San Francisco to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2026.
Explore the most affordable flight options available from San Francisco to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:26 am
SFO
- DSM
1 stop23h 33m
Multiple Airlines
Wed 5/272:16 pm
DSM
- SFO
2 stops26h 32m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:26 am
SFO
- DSM
1 stop23h 33m
Multiple Airlines
Mon 5/259:42 pm
DSM
- SFO
2 stops38h 56m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$249
This Frontier deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:00 am
SFO
- DSM
1 stop5h 34m
Frontier
Mon 7/202:19 pm
DSM
- SFO
1 stop8h 35m
Frontier
Deal found 4/29![Frontier logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/2210:56 pm
SFO
- DSM
1 stop19h 47m
Multiple Airlines
Mon 7/2710:01 pm
DSM
- SFO
1 stop14h 24m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:26 am
SFO
- DSM
1 stop23h 33m
Multiple Airlines
Sun 5/248:00 am
DSM
- SFO
1 stop8h 48m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:26 am
SFO
- DSM
1 stop23h 33m
Multiple Airlines
Fri 5/222:16 pm
DSM
- SFO
1 stop19h 45m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/256:45 pm
SFO
- DSM
2 stops40h 14m
Multiple Airlines
Mon 6/12:16 pm
DSM
- SFO
1 stop23h 31m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$308
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2811:36 am
SFO
- DSM
1 stop7h 08m
Multiple Airlines
Sun 5/3110:26 pm
DSM
- SFO
2 stops23h 10m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/238:45 pm
SFO
- DSM
1 stop14h 10m
Multiple Airlines
Sun 6/288:36 pm
DSM
- SFO
1 stop19h 40m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$324
Best flights from San Francisco to Des MoinesDiscover carefully curated flight deals from San Francisco to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 30, 2026.
Discover carefully curated flight deals from San Francisco to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 30, 2026.
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/15:10 am
SFO
- DSM
1 stop7h 40m
Southwest
Tue 8/117:15 am
DSM
- SFO
2 stops7h 20m
Southwest
Deal found 4/27![Southwest logo]()
$430
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/165:55 am
SFO
- DSM
2 stops8h 59m
Delta
Fri 6/196:50 am
DSM
- SFO
1 stop6h 45m
Delta
Deal found 4/25![Delta logo]()
$495
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/195:05 am
SFO
- DSM
1 stop7h 00m
United Airlines
Sun 8/235:00 am
DSM
- SFO
1 stop7h 26m
United Airlines
Deal found 4/27![United Airlines logo]()
$525
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/2310:25 am
SFO
- DSM
2 stops9h 15m
Southwest
Sun 6/286:10 am
DSM
- SFO
2 stops7h 35m
Southwest
Deal found 4/29![Southwest logo]()
$435
This Southwest deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/810:25 am
SFO
- DSM
1 stop5h 55m
Southwest
Sat 7/113:35 pm
DSM
- SFO
1 stop9h 55m
Southwest
Deal found 4/28![Southwest logo]()
$467
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:05 am
SFO
- DSM
1 stop7h 00m
United Airlines
Sat 9/266:15 am
DSM
- SFO
1 stop7h 24m
United Airlines
Deal found 4/25![United Airlines logo]()
$567
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/89:25 am
SFO
- DSM
2 stops10h 55m
Southwest
Thu 6/116:10 am
DSM
- SFO
2 stops7h 10m
Southwest
Deal found 4/29![Southwest logo]()
$473
This Southwest deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2011:00 am
SFO
- DSM
2 stops9h 20m
Southwest
Wed 7/293:45 pm
DSM
- SFO
2 stops9h 40m
Southwest
Deal found 4/26![Southwest logo]()
$477
Last-minute flights from San Francisco to Des MoinesDiscover last-minute flight deals from San Francisco to Des Moines. Data last updated April 30, 2026 and is based on user searches.
Discover last-minute flight deals from San Francisco to Des Moines. Data last updated April 30, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:26 am
SFO
- DSM
1 stop23h 33m
Multiple Airlines
Wed 5/272:16 pm
DSM
- SFO
2 stops26h 32m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:26 am
SFO
- DSM
1 stop23h 33m
Multiple Airlines
Mon 5/259:42 pm
DSM
- SFO
2 stops38h 56m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$249
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:26 am
SFO
- DSM
1 stop23h 33m
Multiple Airlines
Sun 5/248:00 am
DSM
- SFO
1 stop8h 48m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:26 am
SFO
- DSM
1 stop23h 33m
Multiple Airlines
Fri 5/222:16 pm
DSM
- SFO
1 stop19h 45m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/208:28 pm
SFO
- DSM
1 stop22h 16m
Multiple Airlines
Wed 5/272:16 pm
DSM
- SFO
2 stops26h 32m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$337
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/213:33 pm
SFO
- DSM
1 stop27h 19m
Multiple Airlines
Wed 5/272:16 pm
DSM
- SFO
2 stops26h 32m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$344
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/256:45 pm
SFO
- DSM
2 stops40h 14m
Multiple Airlines
Mon 6/12:16 pm
DSM
- SFO
1 stop23h 31m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$308
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2811:36 am
SFO
- DSM
1 stop7h 08m
Multiple Airlines
Sun 5/3110:26 pm
DSM
- SFO
2 stops23h 10m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:25 pm
SFO
- DSM
2 stops18h 06m
Multiple Airlines
Fri 5/299:36 pm
DSM
- SFO
1 stop21h 05m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$341
One-way flights from San Francisco to Des MoinesSearch for one-way flight options from San Francisco to Des Moines. Find affordable one-way fares based on user searches. Data last updated April 30, 2026.
Search for one-way flight options from San Francisco to Des Moines. Find affordable one-way fares based on user searches. Data last updated April 30, 2026.
This Frontier deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:00 am
SFO
- DSM
1 stop5h 31m
Frontier
Deal found 4/28![Frontier logo]()
$105
This eDestinos deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/210:45 pm
SFO
- DSM
1 stop12h 10m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$115
This CheapOair deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2812:52 pm
SFO
- DSM
1 stop22h 39m
Frontier
Deal found 4/29![Frontier logo]()
$131
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/256:45 pm
SFO
- DSM
2 stops40h 14m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$162
This Trip.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1811:31 am
SFO
- DSM
1 stop9h 02m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$166
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/2610:56 pm
SFO
- DSM
2 stops21h 34m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$190
This United Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2012:45 pm
SFO
- DSM
1 stop5h 31m
United Airlines
Deal found 4/26![United Airlines logo]()
$192
Find flight deals from San Francisco to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $237 (Kiwi.com) |
One-way from | $105 (Frontier) |
Popular in | January |
Cheapest in | February |
Average price | $596 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Francisco to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2026.
Use the filters below to find and compare flights from San Francisco to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Sat 8/1
5:10 am-2:50 pm
1 stop7h 40m
Des Moines
Tue 8/11
7:15 am-12:35 pm
2 stops7h 20m
$430
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Tue 6/23
10:25 am-9:40 pm
2 stops9h 15m
Des Moines
Sun 6/28
6:10 am-11:45 am
2 stops7h 35m
$435
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Wed 7/8
10:25 am-6:20 pm
1 stop5h 55m
Des Moines
Sat 7/11
3:35 pm-11:30 pm
1 stop9h 55m
$467
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Mon 6/8
9:25 am-10:20 pm
2 stops10h 55m
Des Moines
Thu 6/11
6:10 am-11:20 am
2 stops7h 10m
$473
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Mon 7/20
11:00 am-10:20 pm
2 stops9h 20m
Des Moines
Wed 7/29
3:45 pm-11:25 pm
2 stops9h 40m
$477
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Tue 6/16
5:55 am-4:54 pm
2 stops8h 59m
Des Moines
Fri 6/19
6:50 am-11:35 am
1 stop6h 45m
$495
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Wed 8/19
5:05 am-2:05 pm
1 stop7h 00m
Des Moines
Sun 8/23
5:00 am-10:26 am
1 stop7h 26m
$525
Quickest round-trip
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Sat 9/12
5:05 am-2:05 pm
1 stop7h 00m
Des Moines
Sat 9/26
6:15 am-11:39 am
1 stop7h 24m
$567
Cheapest one-way
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Tue 6/2
10:45 pm-12:55 pm
1 stop12h 10m
$125
San FranciscoDes Moines
SFO - DSM
SFODSM
San Francisco
Mon 6/1
10:58 pm-1:31 pm
2 stops36h 33m
$131
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from San Francisco to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Des Moines in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on San Francisco-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Francisco-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Francisco to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from San Francisco with our price prediction graph.
SFO-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Francisco to Des Moines
How far ahead should I book a flight from San Francisco to Des Moines?
The best time to book flights from San Francisco to Des Moines is 80 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from San Francisco to Des Moines?
Currently, February is the cheapest month in which you can book a flight from San Francisco to Des Moines (average of $280). Flying from San Francisco to Des Moines in January is currently the most expensive (average of $865). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from San Francisco to Des Moines?
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated April 30, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from San Francisco to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Entertainment
7.5
Comfort
8.0
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Crew
8.6
Entertainment
7.5
Comfort
8.0
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Crew
8.6
Entertainment
7.5
Comfort
8.0
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Crew
8.6
Entertainment
7.5
Comfort
8.0
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Crew
8.6
Entertainment
7.5
Comfort
8.0
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Crew
8.6
Entertainment
7.5
Comfort
8.0
Overall
8.0
Boarding
8.1
Food
7.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Related info for your journey
Find useful and relevant information for your journey from San Francisco to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Johnston
Ames
Clive
Boone
West Des Moines
Ankeny
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Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 30, 2026.
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San Francisco and Des Moines flights
Browse other San Francisco and Des Moines flight options. Last updated on April 30, 2026.
Other flights from San Francisco
Browse through other flights departing from San Francisco. Flights are based on user searches made on Cheapflights and were last updated on April 30, 2026.
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Top 5 airlines flying from San Francisco to Des Moines
Discover the top 5 airlines that operate flights from San Francisco to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$149 | Average$280 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$295 | Average$608 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$334 | Average$517 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$346 | Average$496 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$386 | Average$531 | FlexibilityNo cancel fee | On-time69% |