$89+ Cheap flights from San Francisco to Des Moines (SFO - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/2. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — DSM
Nov 24 — Dec 11
Round-trip
1 adult, Economy
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Find cheap flights from San Francisco to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Francisco to Des Moines
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Cheapest flights from San Francisco to Des MoinesExplore the most affordable flight options available from San Francisco to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
Explore the most affordable flight options available from San Francisco to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1211:06 am -
1 stop6h 58m
Mon 11/168:04 pm -
1 stop14h 15m
Deal found 10/23![Multiple Airlines logo]()
$242
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:14 pm -
1 stop22h 50m
Mon 11/168:04 pm -
1 stop20h 16m
Deal found 10/21![Multiple Airlines logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/194:57 pm -
2 stops25h 44m
Mon 11/239:31 pm -
1 stop15h 30m
Deal found 10/23![Multiple Airlines logo]()
$258
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1212:20 pm -
1 stop29h 15m
Mon 11/168:30 pm -
2 stops21h 32m
Deal found 10/20![Frontier logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/259:23 pm -
1 stop20h 10m
Thu 12/38:35 pm -
2 stops18h 40m
Deal found 10/22![Frontier logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/511:06 am -
1 stop6h 28m
Mon 11/98:04 pm -
1 stop14h 15m
Deal found 10/21![Multiple Airlines logo]()
$276
This Frontier deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/310:39 am -
1 stop7h 01m
Sun 12/68:45 pm -
1 stop6h 05m
Deal found 10/20![Frontier logo]()
$285
Best flights from San Francisco to Des MoinesDiscover carefully curated flight deals from San Francisco to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
Discover carefully curated flight deals from San Francisco to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1311:35 pm -
1 stop10h 25m
Tue 11/177:00 am -
1 stop6h 10m
Deal found 10/21![Southwest logo]()
$308
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:00 am -
1 stop10h 07m
Mon 11/167:55 pm -
1 stop6h 06m
Deal found 10/22![Delta logo]()
$317
This KAYAK deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1611:39 pm -
1 stop7h 07m
Thu 11/197:16 pm -
1 stop7h 31m
Deal found 10/23![American Airlines logo]()
$437
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/49:59 pm -
1 stop10h 50m
Mon 12/72:58 pm -
1 stop9h 50m
Deal found 10/20![Delta logo]()
$362
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/115:20 am -
1 stop8h 55m
Sun 2/1410:50 am -
2 stops9h 35m
Deal found 10/22![Southwest logo]()
$429
This KAYAK deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/88:40 am -
1 stop6h 47m
Sat 11/217:16 pm -
1 stop7h 31m
Deal found 10/22![American Airlines logo]()
$516
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:50 am -
2 stops9h 45m
Tue 11/107:00 am -
1 stop6h 10m
Deal found 10/21![Southwest logo]()
$475
This Southwest deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/245:25 am -
1 stop7h 40m
Fri 11/276:40 am -
2 stops8h 25m
Deal found 10/24![Southwest logo]()
$490
This KAYAK deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:05 am -
1 stop6h 20m
Fri 11/207:55 pm -
1 stop6h 06m
Deal found 10/22![Delta logo]()
$567
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/76:30 am -
2 stops8h 50m
Wed 11/1112:05 pm -
2 stops8h 15m
Deal found 10/23![Southwest logo]()
$530
Last-minute flights from San Francisco to Des MoinesDiscover last-minute flight deals from San Francisco to Des Moines. Data last updated October 25, 2026 and is based on user searches.
Discover last-minute flight deals from San Francisco to Des Moines. Data last updated October 25, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/511:06 am -
1 stop6h 28m
Mon 11/98:04 pm -
1 stop14h 15m
Deal found 10/21![Multiple Airlines logo]()
$276
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:14 pm -
1 stop22h 50m
Mon 11/168:04 pm -
1 stop20h 16m
Deal found 10/21![Multiple Airlines logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1211:06 am -
1 stop6h 58m
Mon 11/168:04 pm -
1 stop14h 15m
Deal found 10/23![Multiple Airlines logo]()
$242
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1212:20 pm -
1 stop29h 15m
Mon 11/168:30 pm -
2 stops21h 32m
Deal found 10/20![Frontier logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/194:57 pm -
2 stops25h 44m
Mon 11/239:31 pm -
1 stop15h 30m
Deal found 10/23![Multiple Airlines logo]()
$258
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/259:23 pm -
1 stop20h 10m
Thu 12/38:35 pm -
2 stops18h 40m
Deal found 10/22![Frontier logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/259:23 pm -
1 stop20h 10m
Mon 11/309:39 pm -
2 stops26h 04m
Deal found 10/22![Multiple Airlines logo]()
$288
One-way flights from San Francisco to Des MoinesSearch for one-way flight options from San Francisco to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
Search for one-way flight options from San Francisco to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/26:30 pm -
1 stop25h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Multiple Airlines logo]()
$89
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/72:17 pm -
1 stop22h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Multiple Airlines logo]()
$111
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/97:26 pm -
1 stop22h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Frontier logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/167:26 pm -
1 stop22h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Frontier logo]()
$129
This Expedia deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:02 am -
1 stop11h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Frontier logo]()
$132
This Travelocity deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/176:15 am -
1 stop11h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/21![Frontier logo]()
$137
This Trip.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/259:23 pm -
1 stop20h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![Frontier logo]()
$139
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/171:20 pm -
1 stop5h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/20![Southwest logo]()
$152
Find flight deals from San Francisco to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 25, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $242 (Kiwi.com) |
One-way from | $89 (Kiwi.com) |
Popular in | January |
Cheapest in | February |
Average price | $692 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Francisco to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
Use the filters below to find and compare flights from San Francisco to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San FranciscoDes Moines
SFO San Francisco - DSM Des Moines
SFODSM
San Francisco
Wed 12/9
7:26 pm-7:42 pm
1 stop22h 16m
Des Moines
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$147
Quickest round-trip
San FranciscoDes Moines
SFO San Francisco - DSM Des Moines
SFODSM
San Francisco
Tue 11/17
1:20 pm-8:50 pm
1 stop5h 30m
Des Moines
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$152
San FranciscoDes Moines
SFO San Francisco - DSM Des Moines
SFODSM
San Francisco
Sun 12/20
5:10 am-5:00 pm
1 stop9h 50m
Des Moines
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$157
San FranciscoDes Moines
SFO San Francisco - DSM Des Moines
SFODSM
San Francisco
Wed 12/9
9:59 pm-10:49 am
1 stop10h 50m
Des Moines
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$159
San FranciscoDes Moines
SFO San Francisco - DSM Des Moines
SFODSM
San Francisco
Tue 12/15
11:39 pm-10:21 am
1 stop8h 42m
Des Moines
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$159
San FranciscoDes Moines
SFO San Francisco - DSM Des Moines
SFODSM
San Francisco
Tue 12/8
10:40 pm-9:50 am
1 stop9h 10m
Des Moines
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$159
San FranciscoDes Moines
SFO San Francisco - DSM Des Moines
SFODSM
San Francisco
Tue 11/24
3:29 pm-7:33 pm
2 stops50h 04m
Des Moines
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$173
San FranciscoDes Moines
SFO San Francisco - DSM Des Moines
SFODSM
San Francisco
Thu 12/17
3:56 pm-8:45 pm
1 stop26h 49m
Des Moines
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$177
San FranciscoDes Moines
SFO San Francisco - DSM Des Moines
SFODSM
San Francisco
Fri 11/13
11:35 pm-12:00 pm
1 stop10h 25m
Des Moines
Tue 11/17
7:00 am-11:10 am
1 stop6h 10m
$308
San FranciscoDes Moines
SFO San Francisco - DSM Des Moines
SFODSM
San Francisco
Wed 11/11
6:00 am-6:07 pm
1 stop10h 07m
Des Moines
Mon 11/16
7:55 pm-12:01 am
1 stop6h 06m
$317
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from San Francisco to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Francisco to Des Moines in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on San Francisco-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Francisco-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Francisco-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Francisco-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Francisco-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Francisco to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from San Francisco with our price prediction graph.
SFO-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Francisco to Des Moines
What is the cheapest month to book a flight from San Francisco to Des Moines?
Currently, February is the cheapest month in which you can book a flight from San Francisco to Des Moines (average of $280). Flying from San Francisco to Des Moines in January is currently the most expensive (average of $865). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from San Francisco to Des Moines?
Airfare is below average for this route at the moment.
San Francisco to Des Moines flights typically cost between $422 and $818 in November.The cheapest round-trip price found within the last 5 days was $242 on Multiple Airlines (Nov 12-Nov 16).
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated October 25, 2026.
Read reviews from past customers who have flown Southwest,United Airlines, andAmerican Airlines from San Francisco to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.9
Comfort
8.0
Crew
8.6
Entertainment
7.4
Boarding
8.1
Food
7.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Overall
7.9
Comfort
8.0
Crew
8.6
Entertainment
7.4
Boarding
8.1
Food
7.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Overall
7.9
Comfort
8.0
Crew
8.6
Entertainment
7.4
Boarding
8.1
Food
7.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Overall
7.9
Comfort
8.0
Crew
8.6
Entertainment
7.4
Boarding
8.1
Food
7.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Overall
7.9
Comfort
8.0
Crew
8.6
Entertainment
7.4
Boarding
8.1
Food
7.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from San Francisco to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
West Des Moines
Ames
Johnston
Boone
Norwalk
Ankeny
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Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 25, 2026.
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San Francisco and Des Moines flights
Browse other San Francisco and Des Moines flight options. Last updated on October 25, 2026.
Other flights from San Francisco
Browse through other flights departing from San Francisco. Flights are based on user searches made on Cheapflights and were last updated on October 25, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from San Francisco to Des Moines
Discover the top 4 airlines that operate flights from San Francisco to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$230 | Average$321 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$324 | Average$906 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$326 | Average$556 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$358 | Average$449 | FlexibilityNo cancel fee | On-time63% |