What are the cheapest airlines flying from San Diego to Des Moines round-trip?

Our cheapest airline available from San Diego to Des Moines is Allegiant Air. Our recent data shows that you can find tickets from as low as $116 on this airline. Additional options worth looking into are Frontier and American Airlines, starting at $258 and $287 round-trip. These flights start at 72% lower than the current average price 3 months from now.

What are the cheapest airlines to fly from San Diego to Des Moines one-way?

To fly one-way, consider booking your trip with Allegiant Air, which is currently one of the cheapest options available, starting at $90. Frontier flights start at $95 while deals on American Airlines start at $144 one-way.

What is the cheapest day to fly from San Diego to Des Moines?

Travelers seeking maximum savings on their San Diego to Des Moines flight should consider departing on Sunday afternoons when fares are most often at their lowest. Saturday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

What are the cheapest flights from San Diego to Des Moines?

The cheapest flight price from San Diego to Des Moines is $74. On average you can expect to pay $103. The most popular route, (San Diego - Des Moines), can usually be booked for $139.

What are the most popular airlines that fly from San Diego to Des Moines?

The most popular airlines flying from San Diego to Des Moines are American Airlines, Delta and Frontier. Something to consider prior to booking your flight.

What is the cheapest day to fly round-trip from San Diego to Des Moines?

Users have found that leaving on a Saturday can be a cost-effective option. It’s possible to save up to 211% on your flight compared to booking on days when demand is much higher.

How far in advance should I book a flight from San Diego to Des Moines?

Travelers have found it’s best to book a flight 27 days in advance to save up to 128% compared to booking the same week of travel. As your travel date approaches, the cost of this flight route may potentially increase. While opting to book 27 days out may not be an option for all, there are still additional ways to secure a deal in the near future. You might find a flight from San Diego to Des Moines 1-2 weeks in advance for as low as $290, or $372 for flights within the next 24 hours.

What is the cheapest month to fly from San Diego to Des Moines?

August is one of the best times of the year to fly to Des Moines from San Diego. Prices for August average $425 per person but you can even find prices for as low as $200. The most expensive prices can be found in the month of February. Opting for a August flight can save you 27% on your journey compared to booking in February

Most accurate provider : When it comes to deals on San Diego-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Diego-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Diego-Des Moines flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on San Diego-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Diego-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from San Diego to Des Moines that include hotel bookings?

Yes. In addition to deals on San Diego to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from San Diego to Des Moines?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to Des Moines.

Can I find deals for business class flights from San Diego to Des Moines?

Yes. Cheapflights offers flight deals from San Diego to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$90+ Flights from San Diego to Des Moines

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from San Diego to Des Moines with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from San Diego to Des Moines are usually found in August or May, booked 84 days in advance, depart on a Friday or Monday and return on a Monday

Cheap flight deals from San Diego to Des Moines

Most accurate provider	FlightHub 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$116 (Mytrip)
One-way from	$90 (Booking.com)
Popular in	February
Cheapest in	August
Average price	$373

Provider with most accurate pricing for San Diego-Des Moines flight deals.

Search Deals

Provider most trusted by Cheapflights users for San Diego-Des Moines flights.

Search Deals

From San Diego to Des Moines

Search Deals

One-way flight from San Diego to Des Moines

Search Deals

Highest demand for flights based on searches. 12% potential increase in price ($58 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($11 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in April 2025

Search Deals

Find flight deals from San Diego to Des Moines

Cheapest flights from San Diego to Des Moines
Explore the most affordable flight options available from San Diego to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2025.

Fri 5/235:09 pmSAN - DSM

Nonstop3h 24mAllegiant Air

Mon 5/262:43 pmDSM - SAN

Nonstop3h 36mAllegiant Air

Deal found 4/28

$116

Thu 5/226:15 amSAN - DSM

1 stop13h 17mMultiple Airlines

Mon 5/262:43 pmDSM - SAN

Nonstop3h 36mMultiple Airlines

Deal found 4/28

$188

Mon 5/56:25 amSAN - DSM

1 stop10h 05mFrontier

Mon 5/127:20 pmDSM - SAN

1 stop6h 53mFrontier

Deal found 4/28

$198

Tue 5/202:27 pmSAN - DSM

1 stop6h 29mAmerican Airlines

Tue 6/177:21 pmDSM - SAN

1 stop6h 35mAmerican Airlines

Deal found 4/28

$287

Fri 5/3011:55 amSAN - DSM

2 stops8h 15mSouthwest

Tue 6/33:40 pmDSM - SAN

1 stop7h 00mSouthwest

Deal found 4/27

$343

Tue 5/207:15 pmSAN - DSM

2 stops13h 04mDelta

Tue 6/1710:18 amDSM - SAN

1 stop9h 47mDelta

Deal found 4/28

$361

Tue 5/202:30 pmSAN - DSM

2 stops7h 09mUnited Airlines

Tue 6/176:00 amDSM - SAN

2 stops8h 28mUnited Airlines

Deal found 4/28

$377

Thu 6/128:45 pmSAN - DSM

2 stops18h 43mAlaska Airlines

Mon 6/165:58 pmDSM - SAN

2 stops16h 55mAlaska Airlines

Deal found 4/28

$607

Best flights from San Diego to Des Moines
Discover carefully curated flight deals from San Diego to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 28, 2025.

Fri 5/235:09 pmSAN - DSM

Nonstop3h 24mAllegiant Air

Mon 5/262:43 pmDSM - SAN

Nonstop3h 36mAllegiant Air

Deal found 4/28

$116

Thu 5/226:15 amSAN - DSM

1 stop13h 17mMultiple Airlines

Mon 5/262:43 pmDSM - SAN

Nonstop3h 36mMultiple Airlines

Deal found 4/28

$188

Fri 6/66:25 amSAN - DSM

1 stop11h 28mFrontier

Mon 6/98:38 pmDSM - SAN

1 stop5h 17mFrontier

Deal found 4/28

$258

Tue 5/202:27 pmSAN - DSM

1 stop6h 29mAmerican Airlines

Tue 6/177:21 pmDSM - SAN

1 stop6h 35mAmerican Airlines

Deal found 4/28

$287

Fri 5/3011:55 amSAN - DSM

2 stops8h 15mSouthwest

Tue 6/33:40 pmDSM - SAN

1 stop7h 00mSouthwest

Deal found 4/27

$343

Tue 5/207:15 pmSAN - DSM

2 stops13h 04mDelta

Tue 6/1710:18 amDSM - SAN

1 stop9h 47mDelta

Deal found 4/28

$361

Tue 5/202:30 pmSAN - DSM

2 stops7h 09mUnited Airlines

Tue 6/176:00 amDSM - SAN

2 stops8h 28mUnited Airlines

Deal found 4/28

$377

Thu 6/128:45 pmSAN - DSM

2 stops18h 43mAlaska Airlines

Mon 6/165:58 pmDSM - SAN

2 stops16h 55mAlaska Airlines

Deal found 4/28

$607

Last-minute flights from San Diego to Des Moines
Discover last-minute flight deals from San Diego to Des Moines. Data last updated April 28, 2025 and is based on user searches.

Mon 5/56:25 amSAN - DSM

1 stop10h 05mFrontier

Mon 5/127:20 pmDSM - SAN

1 stop6h 53mFrontier

Deal found 4/28

$198

Mon 5/56:25 amSAN - DSM

1 stop10h 05mMultiple Airlines

Mon 5/1211:53 amDSM - SAN

2 stops12h 51mMultiple Airlines

Deal found 4/28

$438

Wed 5/77:10 amSAN - DSM

1 stop11h 24mUnited Airlines

Sat 5/105:45 amDSM - SAN

1 stop17h 10mUnited Airlines

Deal found 4/28

$623

Tue 5/202:27 pmSAN - DSM

1 stop6h 29mAmerican Airlines

Tue 6/177:21 pmDSM - SAN

1 stop6h 35mAmerican Airlines

Deal found 4/28

$287

Tue 5/207:15 pmSAN - DSM

2 stops13h 04mDelta

Tue 6/1710:18 amDSM - SAN

1 stop9h 47mDelta

Deal found 4/28

$361

Tue 5/202:30 pmSAN - DSM

2 stops7h 09mUnited Airlines

Tue 6/176:00 amDSM - SAN

2 stops8h 28mUnited Airlines

Deal found 4/28

$377

Thu 5/226:15 amSAN - DSM

1 stop13h 17mMultiple Airlines

Mon 5/262:43 pmDSM - SAN

Nonstop3h 36mMultiple Airlines

Deal found 4/28

$188

Fri 5/235:09 pmSAN - DSM

Nonstop3h 24mAllegiant Air

Mon 5/262:43 pmDSM - SAN

Nonstop3h 36mAllegiant Air

Deal found 4/28

$116

Fri 5/3011:55 amSAN - DSM

2 stops8h 15mSouthwest

Tue 6/33:40 pmDSM - SAN

1 stop7h 00mSouthwest

Deal found 4/27

$343

One-way flights from San Diego to Des Moines
Search for one-way flight options from San Diego to Des Moines. Find affordable one-way fares based on user searches. Data last updated April 28, 2025.

Mon 6/235:12 pmSAN - DSM

Nonstop3h 22mAllegiant Air

Deal found 4/28

$90

Mon 5/56:25 amSAN - DSM

1 stop10h 05mFrontier

Deal found 4/28

$95

Thu 5/222:49 pmSAN - DSM

1 stop6h 50mAmerican Airlines

Deal found 4/28

$144

Wed 8/206:15 amSAN - DSM

2 stops7h 58mUnited Airlines

Deal found 4/28

$149

Wed 7/26:20 amSAN - DSM

1 stop5h 43mDelta

Deal found 4/28

$210

Mon 5/1911:55 amSAN - DSM

2 stops8h 15mSouthwest

Deal found 4/28

$249

Tue 5/65:26 pmSAN - DSM

2 stops15h 47mAlaska Airlines

Deal found 4/28

$358

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Diego to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Fri 5/23

5:09 pm-10:33 pm

Nonstop3h 24m

Des Moines

Mon 5/26

2:43 pm-4:19 pm

Nonstop3h 36m

$116

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 5/22

6:15 am-9:32 pm

1 stop13h 17m

Des Moines

Mon 5/26

2:43 pm-4:19 pm

Nonstop3h 36m

$188

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Fri 6/6

6:25 am-7:53 pm

1 stop11h 28m

Des Moines

Mon 6/9

8:38 pm-11:55 pm

1 stop5h 17m

$258

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Tue 5/20

2:27 pm-10:56 pm

1 stop6h 29m

Des Moines

Tue 6/17

7:21 pm-11:56 pm

1 stop6h 35m

$287

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Fri 5/30

11:55 am-10:10 pm

2 stops8h 15m

Des Moines

Tue 6/3

3:40 pm-8:40 pm

1 stop7h 00m

$343

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Tue 5/20

7:15 pm-10:19 am

2 stops13h 04m

Des Moines

Tue 6/17

10:18 am-6:05 pm

1 stop9h 47m

$361

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Tue 5/20

2:30 pm-11:39 pm

2 stops7h 09m

Des Moines

Tue 6/17

6:00 am-12:28 pm

2 stops8h 28m

$377

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Thu 6/12

8:45 pm-5:28 pm

2 stops18h 43m

Des Moines

Mon 6/16

5:58 pm-8:53 am

2 stops16h 55m

$607

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Mon 6/23

5:12 pm-10:34 pm

Nonstop3h 22m

$90

San DiegoDes Moines

SAN - DSM

SANDSM

San Diego

Mon 5/5

6:25 am-6:30 pm

1 stop10h 05m

$95

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/28

Showing 1-10 of 15 results

Compare providers for flights from San Diego to Des Moines

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Diego to Des Moines in April.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy1 star	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*2 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on San Diego-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Diego-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Diego-Des Moines flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on San Diego-Des Moines flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Diego-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from San Diego to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from San Diego with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Diego to Des Moines

How far ahead should I book a flight from San Diego to Des Moines?

Booking 80 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Diego to Des Moines. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

What is the cheapest month to book a flight from San Diego to Des Moines?

Currently, August is the cheapest month in which you can book a flight from San Diego to Des Moines (average of $336). Flying from San Diego to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SAN to DSM?

One of the essential ways to save on airfare from San Diego to Des Moines is to remain as flexible as possible. Flights that are in the evening tend to be the most expensive. A flight in the afternoon could potentially save you up to 65% on airfare.

Rainfall in Des Moines by month

In terms of precipitation, rainfall in Des Moines ranges from 1.0 - 4.9 inches per month. June is typically the wettest month, when rainfall can reach 4.9 in. January is typically the driest time to visit Des Moines when rainfall is around 1.0 in.

Temperature in Des Moines by month

If weather is an important factor for your trip to Des Moines, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 77.0 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 23.0 F).

Reviews of airlines servicing Des Moines

Read through reviews of airlines operating flights from San Diego to Des Moines, such as Alaska Airlines, Southwest and Delta. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Alaska Airlines

8.0

Very good

9,949 reviews

Reviews

1 / 20

10.0

Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

Alaska Airlines

8.0

Very good

9,949 reviews

Alaska Airlines

8.0

Very good

9,949 reviews

Reviews

1 / 20

10.0

Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

Southwest

8.0

Very good

4,292 reviews

Alaska Airlines

8.0

Very good

9,949 reviews

Reviews

1 / 20

10.0

Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

Delta

8.0

Very good

7,929 reviews

Alaska Airlines

8.0

Very good

9,949 reviews

Reviews

1 / 20

10.0

Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

United Airlines

7.4

Good

8,696 reviews

Alaska Airlines

8.0

Very good

9,949 reviews

Reviews

1 / 20

10.0

Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

Allegiant Air

7.3

Good

734 reviews

Alaska Airlines

8.0

Very good

9,949 reviews

Reviews

1 / 20

10.0

Excellent

Cheri,Jan 2025

FAT - SEA

Very friendly. I really liked that they had water for us in cartons not plastic. Impressed with Alaska Airlines, First time I had flown them

Related info for your journey

What are the cheapest airlines flying from San Diego to Des Moines round-trip?
Our cheapest airline available from San Diego to Des Moines is Allegiant Air. Our recent data shows that you can find tickets from as low as $116 on this airline. Additional options worth looking into are Frontier and American Airlines, starting at $258 and $287 round-trip. These flights start at 72% lower than the current average price 3 months from now.
What are the cheapest airlines to fly from San Diego to Des Moines one-way?
To fly one-way, consider booking your trip with Allegiant Air, which is currently one of the cheapest options available, starting at $90. Frontier flights start at $95 while deals on American Airlines start at $144 one-way.
What are the cheapest flights from San Diego to Des Moines?
The cheapest flight price from San Diego to Des Moines is $74. On average you can expect to pay $103. The most popular route, (San Diego - Des Moines), can usually be booked for $139.
Can I find deals for flights from San Diego to Des Moines that include hotel bookings?
Yes. In addition to deals on San Diego to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from San Diego to Des Moines?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to Des Moines.
Can I find deals for business class flights from San Diego to Des Moines?
Yes. Cheapflights offers flight deals from San Diego to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from San Diego to Des Moines?
Currently, August is the cheapest month in which you can book a flight from San Diego to Des Moines (average of $336). Flying from San Diego to Des Moines in June is currently the most expensive (average of $422). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Ames

Altoona

Johnston

Boone

West Des Moines

Ankeny

Browse thousands of different options on Cheapflights for your next trip

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Other flights to Des Moines

Top 6 airlines flying from San Diego to Des Moines

Airline	Cheapest	Average	Flexibility	On-time
Allegiant Air	Cheapest$127	Average$202	FlexibilityNo cancel fee	On-time88%
Frontier	Cheapest$134	Average$262	FlexibilityNo cancel fee	On-time62%
American Airlines	Cheapest$293	Average$408	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$324	Average$432	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$333	Average$487	FlexibilityNo cancel fee	On-time69%
Southwest	Cheapest$336	Average$470	FlexibilityNo cancel fee	On-time63%

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$90+ Cheap flights from San Diego to Des Moines (SAN - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/23. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from San Diego to Des Moines with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from San Diego to Des Moines are usually found in August or May, booked 84 days in advance, depart on a Friday or Monday and return on a Monday

Cheap flight deals from San Diego to Des Moines

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from San Diego to Des Moines

Cheapest flights from San Diego to Des MoinesExplore the most affordable flight options available from San Diego to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2025.

Explore the most affordable flight options available from San Diego to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Diego to Des Moines that are best for you.

Compare providers for flights from San Diego to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Diego to Des Moines in April.

Best time to book a flight from San Diego to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from San Diego with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from San Diego to Des Moines

How far ahead should I book a flight from San Diego to Des Moines?

Use this chart to determine the optimal time to book a round-trip flight from San Diego to Des Moines. Price data was last updated on April 25, 2025.

What is the cheapest month to book a flight from San Diego to Des Moines?

What is the cheapest time of day to fly from SAN to DSM?

Find hourly flight availability from San Diego to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 28, 2025.

Rainfall in Des Moines by month

Plan your trip to Des Moines by taking into account the average rainfall totals by month.

Temperature in Des Moines by month

Plan your trip to Des Moines by taking into account the average temperature totals by month.

Reviews of airlines servicing Des Moines

Read through reviews of airlines operating flights from San Diego to Des Moines, such as Alaska Airlines, Southwest and Delta. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from San Diego to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from San Diego to Des Moines round-trip?

What are the cheapest airlines to fly from San Diego to Des Moines one-way?

What are the cheapest flights from San Diego to Des Moines?

Can I find deals for flights from San Diego to Des Moines that include hotel bookings?

How can I find direct flights from San Diego to Des Moines?

Can I find deals for business class flights from San Diego to Des Moines?

What is the cheapest month to book a flight from San Diego to Des Moines?

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Alternative routes for San Diego to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.

Top 6 airlines flying from San Diego to Des Moines

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Cheapest flights from San Diego to Des Moines
Explore the most affordable flight options available from San Diego to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 28, 2025.