$122+ Cheap flights from San Diego to Des Moines (SAN - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/19. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — DSM
Mar 6 — Mar 131
1 adult, Economy
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Find cheap flights from San Diego to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from San Diego to Des Moines are usually found in November or July, booked 84 days in advance, depart on a Wednesday or Tuesday and return on a Monday
Cheap flight deals from San Diego to Des Moines
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Best
Last-minute
One-way
Cheapest flights from San Diego to Des MoinesExplore the most affordable flight options available from San Diego to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.
Explore the most affordable flight options available from San Diego to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.
This Frontier deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/278:35 am
SAN
- DSM
1 stop8h 29m
Frontier
Mon 3/27:17 pm
DSM
- SAN
1 stop6h 51m
Frontier
Deal found 2/1![Frontier logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/26:25 am
SAN
- DSM
1 stop10h 07m
Frontier
Mon 3/98:21 pm
DSM
- SAN
1 stop26h 53m
Frontier
Deal found 2/1![Frontier logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/208:35 am
SAN
- DSM
1 stop7h 44m
Multiple Airlines
Sun 2/229:00 am
DSM
- SAN
1 stop6h 57m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$242
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:25 am
SAN
- DSM
1 stop10h 49m
Multiple Airlines
Sat 4/410:00 am
DSM
- SAN
1 stop23h 21m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2812:23 pm
SAN
- DSM
1 stop28h 19m
Frontier
Sat 3/78:21 pm
DSM
- SAN
1 stop28h 47m
Frontier
Deal found 2/3![Frontier logo]()
$258
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/208:35 am
SAN
- DSM
1 stop7h 44m
Frontier
Sun 2/227:45 pm
DSM
- SAN
2 stops22h 19m
Frontier
Deal found 2/2![Frontier logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/279:18 pm
SAN
- DSM
1 stop19h 58m
Frontier
Mon 3/308:21 pm
DSM
- SAN
1 stop26h 53m
Frontier
Deal found 2/2![Frontier logo]()
$267
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2812:23 pm
SAN
- DSM
2 stops23h 55m
Multiple Airlines
Sat 3/78:21 pm
DSM
- SAN
1 stop28h 47m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/29:02 pm
SAN
- DSM
1 stop21h 53m
Multiple Airlines
Sat 4/410:00 am
DSM
- SAN
1 stop23h 21m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:25 am
SAN
- DSM
1 stop10h 49m
Frontier
Mon 4/68:14 pm
DSM
- SAN
1 stop21h 22m
Frontier
Deal found 2/2![Frontier logo]()
$294
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:25 am
SAN
- DSM
2 stops35h 46m
Multiple Airlines
Mon 4/68:14 pm
DSM
- SAN
1 stop21h 22m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$305
Best flights from San Diego to Des MoinesDiscover carefully curated flight deals from San Diego to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 4, 2026.
Discover carefully curated flight deals from San Diego to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/208:35 am
SAN
- DSM
1 stop7h 44m
Frontier
Sun 2/227:45 pm
DSM
- SAN
2 stops22h 19m
Frontier
Deal found 2/2![Frontier logo]()
$261
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/44:10 pm
SAN
- DSM
1 stop5h 33m
United Airlines
Wed 3/115:04 pm
DSM
- SAN
1 stop7h 39m
United Airlines
Deal found 2/1![United Airlines logo]()
$307
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1510:40 pm
SAN
- DSM
1 stop10h 50m
American Airlines
Tue 4/216:00 am
DSM
- SAN
1 stop10h 18m
American Airlines
Deal found 2/3![American Airlines logo]()
$310
This Delta deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/3010:30 pm
SAN
- DSM
1 stop10h 18m
Delta
Tue 4/74:25 pm
DSM
- SAN
1 stop9h 15m
Delta
Deal found 2/1![Delta logo]()
$317
This Southwest deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/159:40 am
SAN
- DSM
1 stop6h 15m
Southwest
Tue 4/213:15 pm
DSM
- SAN
2 stops8h 45m
Southwest
Deal found 2/3![Southwest logo]()
$356
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:15 am
SAN
- DSM
1 stop7h 27m
Delta
Fri 4/34:25 pm
DSM
- SAN
1 stop6h 20m
Delta
Deal found 2/2![Delta logo]()
$317
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:15 am
SAN
- DSM
1 stop7h 27m
Delta
Tue 4/76:55 am
DSM
- SAN
1 stop8h 42m
Delta
Deal found 2/2![Delta logo]()
$317
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/303:19 pm
SAN
- DSM
1 stop6h 29m
American Airlines
Tue 4/76:00 am
DSM
- SAN
1 stop10h 18m
American Airlines
Deal found 2/3![American Airlines logo]()
$365
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/108:45 am
SAN
- DSM
1 stop5h 25m
United Airlines
Tue 6/233:24 pm
DSM
- SAN
1 stop9h 10m
United Airlines
Deal found 2/2![United Airlines logo]()
$367
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/910:30 pm
SAN
- DSM
1 stop8h 49m
Delta
Tue 6/235:35 pm
DSM
- SAN
1 stop7h 44m
Delta
Deal found 2/2![Delta logo]()
$367
Last-minute flights from San Diego to Des MoinesDiscover last-minute flight deals from San Diego to Des Moines. Data last updated February 4, 2026 and is based on user searches.
Discover last-minute flight deals from San Diego to Des Moines. Data last updated February 4, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/187:11 am
SAN
- DSM
2 stops29h 08m
Multiple Airlines
Sun 2/227:45 pm
DSM
- SAN
1 stop6h 23m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$349
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/208:35 am
SAN
- DSM
1 stop7h 44m
Multiple Airlines
Sun 2/229:00 am
DSM
- SAN
1 stop6h 57m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$242
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/208:35 am
SAN
- DSM
1 stop7h 44m
Frontier
Sun 2/227:45 pm
DSM
- SAN
2 stops22h 19m
Frontier
Deal found 2/2![Frontier logo]()
$261
This Frontier deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/278:35 am
SAN
- DSM
1 stop8h 29m
Frontier
Mon 3/27:17 pm
DSM
- SAN
1 stop6h 51m
Frontier
Deal found 2/1![Frontier logo]()
$204
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2812:23 pm
SAN
- DSM
1 stop28h 19m
Frontier
Sat 3/78:21 pm
DSM
- SAN
1 stop28h 47m
Frontier
Deal found 2/3![Frontier logo]()
$258
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2812:23 pm
SAN
- DSM
2 stops23h 55m
Multiple Airlines
Sat 3/78:21 pm
DSM
- SAN
1 stop28h 47m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/26:25 am
SAN
- DSM
1 stop10h 07m
Frontier
Mon 3/98:21 pm
DSM
- SAN
1 stop26h 53m
Frontier
Deal found 2/1![Frontier logo]()
$228
This United Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/44:10 pm
SAN
- DSM
1 stop5h 33m
United Airlines
Wed 3/115:04 pm
DSM
- SAN
1 stop7h 39m
United Airlines
Deal found 2/1![United Airlines logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/279:18 pm
SAN
- DSM
1 stop19h 58m
Frontier
Mon 3/308:21 pm
DSM
- SAN
1 stop26h 53m
Frontier
Deal found 2/2![Frontier logo]()
$267
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/3010:10 pm
SAN
- DSM
1 stop9h 36m
Delta
Tue 4/76:55 am
DSM
- SAN
1 stop8h 42m
Delta
Deal found 2/2![Delta logo]()
$317
One-way flights from San Diego to Des MoinesSearch for one-way flight options from San Diego to Des Moines. Find affordable one-way fares based on user searches. Data last updated February 4, 2026.
Search for one-way flight options from San Diego to Des Moines. Find affordable one-way fares based on user searches. Data last updated February 4, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/196:25 am
SAN
- DSM
1 stop29h 04m
Frontier
Deal found 2/3![Frontier logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/242:50 pm
SAN
- DSM
2 stops26h 26m
Frontier
Deal found 2/3![Frontier logo]()
$130
This Trip.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/146:25 am
SAN
- DSM
1 stop10h 51m
Frontier
Deal found 2/3![Frontier logo]()
$142
This Expedia deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:25 am
SAN
- DSM
1 stop5h 04m
Frontier
Deal found 2/3![Frontier logo]()
$151
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/133:12 pm
SAN
- DSM
1 stop6h 37m
American Airlines
Deal found 2/2![American Airlines logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/189:45 am
SAN
- DSM
2 stops35h 27m
Multiple Airlines
Deal found 2/1![Multiple Airlines logo]()
$162
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:20 am
SAN
- DSM
2 stops7h 55m
United Airlines
Deal found 2/2![United Airlines logo]()
$164
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:15 am
SAN
- DSM
3 stops30h 00m
Multiple Airlines
Deal found 2/2![Multiple Airlines logo]()
$182
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/243:19 pm
SAN
- DSM
1 stop6h 21m
American Airlines
Deal found 2/3![American Airlines logo]()
$184
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/186:25 am
SAN
- DSM
1 stop10h 51m
Frontier
Deal found 2/1![Frontier logo]()
$189
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/242:50 pm
SAN
- DSM
3 stops51h 53m
Multiple Airlines
Deal found 2/3![Multiple Airlines logo]()
$192
Find flight deals from San Diego to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from San Diego (SAN) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 4, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $204 (Frontier) |
One-way from | $122 (Kiwi.com) |
Popular in | March |
Cheapest in | November |
Average price | $379 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Diego to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from San Diego to Des Moines that are best for you.
Fly from
San Diego
Fly to
Des Moines
Route
Depart
Return
Price
San DiegoDes Moines
SAN - DSM
SANDSM
San Diego
Fri 2/20
8:35 am-6:19 pm
1 stop7h 44m
Des Moines
Sun 2/22
7:45 pm-4:04 pm
2 stops22h 19m
$261
San DiegoDes Moines
SAN - DSM
SANDSM
San Diego
Wed 3/4
4:10 pm-11:43 pm
1 stop5h 33m
Des Moines
Wed 3/11
5:04 pm-10:43 pm
1 stop7h 39m
$307
San DiegoDes Moines
SAN - DSM
SANDSM
San Diego
Wed 4/15
10:40 pm-11:30 am
1 stop10h 50m
Des Moines
Tue 4/21
6:00 am-2:18 pm
1 stop10h 18m
$310
San DiegoDes Moines
SAN - DSM
SANDSM
San Diego
Mon 3/30
10:30 pm-10:48 am
1 stop10h 18m
Des Moines
Tue 4/7
4:25 pm-11:40 pm
1 stop9h 15m
$317
San DiegoDes Moines
SAN - DSM
SANDSM
San Diego
Wed 4/1
6:15 am-3:42 pm
1 stop7h 27m
Des Moines
Fri 4/3
4:25 pm-8:45 pm
1 stop6h 20m
$317
San DiegoDes Moines
SAN - DSM
SANDSM
San Diego
Wed 4/1
6:15 am-3:42 pm
1 stop7h 27m
Des Moines
Tue 4/7
6:55 am-1:37 pm
1 stop8h 42m
$317
San DiegoDes Moines
SAN - DSM
SANDSM
San Diego
Wed 4/15
9:40 am-5:55 pm
1 stop6h 15m
Des Moines
Tue 4/21
3:15 pm-10:00 pm
2 stops8h 45m
$356
San DiegoDes Moines
SAN - DSM
SANDSM
San Diego
Mon 3/30
3:19 pm-11:48 pm
1 stop6h 29m
Des Moines
Tue 4/7
6:00 am-2:18 pm
1 stop10h 18m
$365
San DiegoDes Moines
SAN - DSM
SANDSM
San Diego
Wed 6/10
8:45 am-4:10 pm
1 stop5h 25m
Des Moines
Tue 6/23
3:24 pm-10:34 pm
1 stop9h 10m
$367
San DiegoDes Moines
SAN - DSM
SANDSM
San Diego
Tue 6/9
10:30 pm-9:19 am
1 stop8h 49m
Des Moines
Tue 6/23
5:35 pm-11:19 pm
1 stop7h 44m
$367
Showing 1-10 of 21 results
Compare providers for flights from San Diego to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Diego to Des Moines in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on San Diego-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Diego-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Diego-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Diego-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Diego-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Diego to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from San Diego with our price prediction graph.
SAN-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Diego to Des Moines
How far ahead should I book a flight from San Diego to Des Moines?
Use this chart to determine the optimal time to book a round-trip flight from San Diego to Des Moines. Price data was last updated on January 30, 2026.
Booking 80 days in advance of your planned departure date is, on average, the best time to get cheap flights from San Diego to Des Moines. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from San Diego to Des Moines?
Currently, July is the cheapest month in which you can book a flight from San Diego to Des Moines (average of $75). Flying from San Diego to Des Moines in August is currently the most expensive (average of $172). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated February 4, 2026.
Peruse reviews from past customers who have flown with Southwest, United Airlines, and American Airlines from San Diego to Des Moines to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Crew
8.6
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Overall
8.0
Crew
8.6
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Overall
8.0
Crew
8.6
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Overall
8.0
Crew
8.6
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Overall
8.0
Crew
8.6
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Overall
8.0
Crew
8.6
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Food
7.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Related info for your journey
Find useful and relevant information for your journey from San Diego to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny
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Other flights to Des Moines
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San Diego and Des Moines flights
Browse other San Diego and Des Moines flight options. Last updated on February 4, 2026.
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Top 6 airlines flying from San Diego to Des Moines
Discover the top 6 airlines that operate flights from San Diego to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$75 | Average$170 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$148 | Average$322 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$162 | Average$253 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$247 | Average$496 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$286 | Average$395 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$286 | Average$446 | FlexibilityNo cancel fee | On-time71% |