$450+ Cheap flights from Jacksonville, NC to Des Moines (OAJ - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/18. Fares are subject to change and may not be available on all flights or dates of travel.
OAJ — DSM
Oct 13 — Oct 201
Round-trip
1 adult, Economy
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Find cheap flights from Jacksonville to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Jacksonville to Des Moines
Cheapest
Best
Last-minute
One-way
Cheapest flights from Jacksonville to Des MoinesExplore the most affordable flight options available from Jacksonville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 13, 2026.
Explore the most affordable flight options available from Jacksonville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 13, 2026.
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/34:15 pm -
1 stop7h 11m
Mon 10/55:45 am -
1 stop6h 56m
Deal found 9/9![Delta logo]()
$487
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:34 pm -
1 stop4h 52m
Sun 9/205:45 am -
1 stop6h 56m
Deal found 9/10![Delta logo]()
$587
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/31:52 pm -
2 stops8h 44m
Mon 10/57:08 am -
1 stop4h 09m
Deal found 9/12![American Airlines logo]()
$602
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/181:52 pm -
2 stops10h 49m
Sun 9/207:00 am -
1 stop4h 16m
Deal found 9/11![American Airlines logo]()
$616
Best flights from Jacksonville to Des MoinesDiscover carefully curated flight deals from Jacksonville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 13, 2026.
Discover carefully curated flight deals from Jacksonville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 13, 2026.
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/34:15 pm -
1 stop7h 11m
Mon 10/55:45 am -
1 stop6h 56m
Deal found 9/9![Delta logo]()
$487
This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:06 am -
1 stop6h 58m
Mon 10/511:22 am -
1 stop7h 32m
Deal found 9/10![American Airlines logo]()
$507
Last-minute flights from Jacksonville to Des MoinesDiscover last-minute flight deals from Jacksonville to Des Moines. Data last updated September 13, 2026 and is based on user searches.
Discover last-minute flight deals from Jacksonville to Des Moines. Data last updated September 13, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:34 pm -
1 stop4h 52m
Sun 9/205:45 am -
1 stop6h 56m
Deal found 9/10![Delta logo]()
$587
This American Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/181:52 pm -
2 stops10h 49m
Sun 9/207:00 am -
1 stop4h 16m
Deal found 9/11![American Airlines logo]()
$616
This Delta deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/34:15 pm -
1 stop7h 11m
Mon 10/55:45 am -
1 stop6h 56m
Deal found 9/9![Delta logo]()
$487
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/31:52 pm -
2 stops8h 44m
Mon 10/57:08 am -
1 stop4h 09m
Deal found 9/12![American Airlines logo]()
$602
One-way flights from Jacksonville to Des MoinesSearch for one-way flight options from Jacksonville to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 13, 2026.
Search for one-way flight options from Jacksonville to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 13, 2026.
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/182:26 pm -
1 stop4h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/10![Delta logo]()
$450
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/181:52 pm -
2 stops11h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/13![American Airlines logo]()
$465
Find flight deals from Jacksonville to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Jacksonville (OAJ) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 13, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $487 (Delta) |
One-way from | $450 (Delta) |
Cheapflights Fare Finder
Customize your flight search to find flights from Jacksonville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 13, 2026.
Use the filters below to find and compare flights from Jacksonville to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
JacksonvilleDes Moines
OAJ Jacksonville Albert J Ellis - DSM Des Moines
OAJDSM
Jacksonville Albert J Ellis
Fri 9/18
2:26 pm-6:09 pm
1 stop4h 43m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$450
JacksonvilleDes Moines
OAJ Jacksonville Albert J Ellis - DSM Des Moines
OAJDSM
Jacksonville Albert J Ellis
Fri 9/18
1:52 pm-7:48 pm
1 stop6h 56m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$450
JacksonvilleDes Moines
OAJ Jacksonville Albert J Ellis - DSM Des Moines
OAJDSM
Jacksonville Albert J Ellis
Sat 10/3
4:15 pm-10:26 pm
1 stop7h 11m
Des Moines
Mon 10/5
5:45 am-1:41 pm
1 stop6h 56m
$487
JacksonvilleDes Moines
OAJ Jacksonville Albert J Ellis - DSM Des Moines
OAJDSM
Jacksonville Albert J Ellis
Sat 10/3
6:06 am-12:04 pm
1 stop6h 58m
Des Moines
Mon 10/5
11:22 am-7:54 pm
1 stop7h 32m
$507
Sorted by cheapest first
Compare providers for flights from Jacksonville to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Jacksonville to Des Moines in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Jacksonville, North Carolina-Des Moines flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Jacksonville, North Carolina-Des Moines flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Jacksonville, North Carolina-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Jacksonville, North Carolina-Des Moines flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Jacksonville, North Carolina-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Jacksonville to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Jacksonville with our price prediction graph.
OAJ-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated September 13, 2026.
Read reviews from past customers who have flown American Airlines from Jacksonville to Des Moines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
6.4
Overall
7.1
Boarding
7.4
Entertainment
6.8
Comfort
7.2
Crew
7.9
Reviews
1 / 20
2.0
MediocreSusie,Jan 2026
CLT - TPA
Food
6.4
Overall
7.1
Boarding
7.4
Entertainment
6.8
Comfort
7.2
Crew
7.9
Reviews
1 / 20
2.0
MediocreSusie,Jan 2026
CLT - TPA
Related info for your journey
Find useful and relevant information for your journey from Jacksonville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
Ames
Johnston
Boone
Norwalk
West Des Moines
Ankeny
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Other flights to Des Moines
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Jacksonville and Des Moines flights
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Top airline flying from Jacksonville to Des Moines
Discover the top airline that operate flights from Jacksonville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$459 | Average$563 | FlexibilityNo cancel fee | On-time71% |