$125+ Cheap flights from Jacksonville to Des Moines (JAX - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/14. Fares are subject to change and may not be available on all flights or dates of travel.
JAX — DSM
Dec 2 — Dec 91
Round-trip
1 adult, Economy
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Find cheap flights from Jacksonville to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Jacksonville to Des Moines
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Cheapest flights from Jacksonville to Des MoinesExplore the most affordable flight options available from Jacksonville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 2, 2026.
Explore the most affordable flight options available from Jacksonville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 2, 2026.
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/99:00 am -
1 stop6h 44m
Sat 12/122:05 pm -
1 stop7h 47m
Deal found 10/28![American Airlines logo]()
$295
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/911:37 am -
2 stops8h 42m
Sat 12/126:15 am -
1 stop7h 10m
Deal found 10/28![United Airlines logo]()
$300
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:00 am -
1 stop5h 53m
Mon 12/216:43 pm -
1 stop4h 13m
Deal found 10/29![Delta logo]()
$325
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:00 am -
1 stop5h 20m
Mon 12/216:16 pm -
1 stop4h 34m
Deal found 10/28![American Airlines logo]()
$334
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/104:45 pm -
1 stop5h 40m
Mon 12/149:30 am -
2 stops9h 40m
Deal found 10/30![United Airlines logo]()
$344
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:05 am -
2 stops9h 10m
Sat 12/125:20 am -
2 stops6h 40m
Deal found 10/28![Southwest logo]()
$362
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:38 am -
1 stop7h 57m
Fri 12/255:30 am -
2 stops8h 01m
Deal found 10/30![American Airlines logo]()
$383
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/78:45 am -
1 stop13h 05m
Thu 12/107:00 am -
2 stops13h 15m
Deal found 10/30![Southwest logo]()
$390
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/306:14 pm -
1 stop6h 44m
Mon 1/45:30 am -
2 stops8h 01m
Deal found 11/1![American Airlines logo]()
$394
Best flights from Jacksonville to Des MoinesDiscover carefully curated flight deals from Jacksonville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 2, 2026.
Discover carefully curated flight deals from Jacksonville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 2, 2026.
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/99:00 am -
1 stop6h 44m
Sat 12/122:05 pm -
1 stop7h 47m
Deal found 10/28![American Airlines logo]()
$295
This Delta deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1612:00 pm -
1 stop5h 49m
Mon 12/213:45 pm -
1 stop7h 11m
Deal found 10/31![Delta logo]()
$339
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/104:45 pm -
1 stop5h 40m
Mon 12/149:30 am -
2 stops9h 40m
Deal found 10/30![United Airlines logo]()
$344
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/96:05 am -
2 stops9h 10m
Sat 12/125:20 am -
2 stops6h 40m
Deal found 10/28![Southwest logo]()
$362
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:00 am -
1 stop5h 20m
Mon 12/216:16 pm -
1 stop4h 34m
Deal found 10/28![American Airlines logo]()
$334
This Delta deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/306:00 am -
1 stop5h 53m
Mon 1/45:23 pm -
1 stop5h 32m
Deal found 11/1![Delta logo]()
$339
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/78:45 am -
1 stop13h 05m
Thu 12/107:00 am -
2 stops13h 15m
Deal found 10/30![Southwest logo]()
$390
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/69:00 am -
1 stop6h 31m
Sun 1/102:39 pm -
1 stop7h 33m
Deal found 11/1![American Airlines logo]()
$381
This Southwest deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/65:30 am -
2 stops9h 40m
Sun 1/106:55 am -
2 stops8h 45m
Deal found 11/1![Southwest logo]()
$391
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:38 am -
1 stop7h 57m
Fri 12/255:30 am -
2 stops8h 01m
Deal found 10/30![American Airlines logo]()
$383
Last-minute flights from Jacksonville to Des MoinesDiscover last-minute flight deals from Jacksonville to Des Moines. Data last updated November 2, 2026 and is based on user searches.
Discover last-minute flight deals from Jacksonville to Des Moines. Data last updated November 2, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/37:03 pm -
2 stops19h 52m
Fri 11/610:25 pm -
1 stop20h 37m
Deal found 10/31![Multiple Airlines logo]()
$718
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:50 pm -
1 stop7h 36m
Mon 11/96:00 am -
1 stop6h 00m
Deal found 10/29![American Airlines logo]()
$927
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/59:20 am -
2 stops10h 56m
Mon 11/93:01 pm -
1 stop7h 14m
Deal found 10/29![United Airlines logo]()
$932
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1312:35 pm -
1 stop5h 53m
Tue 11/179:55 am -
1 stop7h 06m
Deal found 10/30![United Airlines logo]()
$557
This Southwest deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/133:35 pm -
2 stops8h 30m
Tue 11/177:00 am -
2 stops9h 00m
Deal found 10/30![Southwest logo]()
$567
This Delta deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/244:09 pm -
1 stop7h 26m
Mon 11/3011:36 am -
1 stop3h 54m
Deal found 10/31![Delta logo]()
$438
This Delta deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/244:09 pm -
1 stop7h 26m
Sun 11/296:52 pm -
1 stop4h 01m
Deal found 10/31![Delta logo]()
$448
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:38 am -
1 stop5h 10m
Mon 11/301:58 pm -
2 stops8h 57m
Deal found 10/31![American Airlines logo]()
$563
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/243:44 pm -
2 stops8h 58m
Mon 11/306:45 pm -
2 stops20h 38m
Deal found 10/31![United Airlines logo]()
$676
This Southwest deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:30 am -
2 stops9h 35m
Sun 11/2911:50 am -
2 stops10h 55m
Deal found 10/31![Southwest logo]()
$871
One-way flights from Jacksonville to Des MoinesSearch for one-way flight options from Jacksonville to Des Moines. Find affordable one-way fares based on user searches. Data last updated November 2, 2026.
Search for one-way flight options from Jacksonville to Des Moines. Find affordable one-way fares based on user searches. Data last updated November 2, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/145:47 pm -
2 stops42h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Multiple Airlines logo]()
$125
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/146:00 am -
1 stop5h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Delta logo]()
$148
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/113:55 pm -
1 stop24h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Multiple Airlines logo]()
$151
This Kiwi.com deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/233:56 pm -
1 stop30h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![Multiple Airlines logo]()
$161
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/2311:37 am -
2 stops8h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![United Airlines logo]()
$175
Find flight deals from Jacksonville to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Jacksonville (JAX) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 2, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $240 (Kiwi.com) |
One-way from | $125 (Kiwi.com) |
Popular in | March |
Cheapest in | November |
Average price | $118 |
Cheapflights Fare Finder
Customize your flight search to find flights from Jacksonville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 2, 2026.
Use the filters below to find and compare flights from Jacksonville to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
JacksonvilleDes Moines
JAX Jacksonville - DSM Des Moines
JAXDSM
Jacksonville
Mon 12/14
6:00 am-10:53 am
1 stop5h 53m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$148
JacksonvilleDes Moines
JAX Jacksonville - DSM Des Moines
JAXDSM
Jacksonville
Wed 11/11
3:55 pm-3:25 pm
1 stop24h 30m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$151
JacksonvilleDes Moines
JAX Jacksonville - DSM Des Moines
JAXDSM
Jacksonville
Mon 11/23
3:56 pm-9:53 pm
1 stop30h 57m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$161
JacksonvilleDes Moines
JAX Jacksonville - DSM Des Moines
JAXDSM
Jacksonville
Mon 12/14
11:37 am-7:19 pm
2 stops8h 42m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$175
JacksonvilleDes Moines
JAX Jacksonville - DSM Des Moines
JAXDSM
Jacksonville
Mon 11/23
11:37 am-7:16 pm
2 stops8h 39m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$175
JacksonvilleDes Moines
JAX Jacksonville - DSM Des Moines
JAXDSM
Jacksonville
Wed 12/9
9:00 am-2:44 pm
1 stop6h 44m
Des Moines
Sat 12/12
2:05 pm-10:52 pm
1 stop7h 47m
$295
JacksonvilleDes Moines
JAX Jacksonville - DSM Des Moines
JAXDSM
Jacksonville
Mon 11/16
4:45 pm-9:55 pm
1 stop6h 10m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$334
JacksonvilleDes Moines
JAX Jacksonville - DSM Des Moines
JAXDSM
Jacksonville
Wed 12/16
6:00 am-10:20 am
1 stop5h 20m
Des Moines
Mon 12/21
6:16 pm-11:50 pm
1 stop4h 34m
$334
JacksonvilleDes Moines
JAX Jacksonville - DSM Des Moines
JAXDSM
Jacksonville
Wed 12/16
12:00 pm-4:49 pm
1 stop5h 49m
Des Moines
Mon 12/21
3:45 pm-11:56 pm
1 stop7h 11m
$339
JacksonvilleDes Moines
JAX Jacksonville - DSM Des Moines
JAXDSM
Jacksonville
Wed 12/30
6:00 am-10:53 am
1 stop5h 53m
Des Moines
Mon 1/4
5:23 pm-11:55 pm
1 stop5h 32m
$339
Showing 1-10 of 16 resultsSorted by cheapest first
Compare providers for flights from Jacksonville to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Jacksonville to Des Moines in November.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Jacksonville-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Jacksonville-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Jacksonville-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Jacksonville-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Jacksonville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Jacksonville to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Jacksonville with our price prediction graph.
JAX-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated November 2, 2026.
Read through reviews of airlines operating flights from Jacksonville to Des Moines, such as Delta,United Airlines, andAllegiant Air. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Overall
7.8
Entertainment
7.8
Food
7.2
Boarding
8.1
Crew
8.5
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Comfort
7.8
Overall
7.8
Entertainment
7.8
Food
7.2
Boarding
8.1
Crew
8.5
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Comfort
7.8
Overall
7.8
Entertainment
7.8
Food
7.2
Boarding
8.1
Crew
8.5
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Comfort
7.8
Overall
7.8
Entertainment
7.8
Food
7.2
Boarding
8.1
Crew
8.5
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Comfort
7.8
Overall
7.8
Entertainment
7.8
Food
7.2
Boarding
8.1
Crew
8.5
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Jacksonville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
West Des Moines
Ames
Johnston
Boone
Norwalk
Ankeny
Browse thousands of different options on Cheapflights for your next trip
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Complete your trip
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Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on November 2, 2026.
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Find flights from Jacksonville to Des Moines, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Jacksonville and Des Moines flights
Browse other Jacksonville and Des Moines flight options. Last updated on November 2, 2026.
Other flights from Jacksonville
Browse through other flights departing from Jacksonville. Flights are based on user searches made on Cheapflights and were last updated on November 2, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from Jacksonville to Des Moines
Discover the top 4 airlines that operate flights from Jacksonville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 2, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$40 | Average$113 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$202 | Average$507 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$286 | Average$406 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$298 | Average$426 | FlexibilityNo cancel fee | On-time69% |