$68+ Cheap flights from Jacksonville to Des Moines (JAX - DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/2. Fares are subject to change and may not be available on all flights or dates of travel.
JAX — DSM
May 19 — May 261
Round-trip
1 adult, Economy
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Find cheap flights from Jacksonville to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Jacksonville to Des Moines
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Cheapest flights from Jacksonville to Des MoinesExplore the most affordable flight options available from Jacksonville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 19, 2026.
Explore the most affordable flight options available from Jacksonville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/58:23 pm
JAX
- DSM
Nonstop2h 35m
Allegiant Air
Sun 7/123:59 pm
DSM
- JAX
Nonstop2h 34m
Allegiant Air
Deal found 4/17![Allegiant Air logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/49:21 pm
JAX
- DSM
Nonstop2h 37m
Multiple Airlines
Mon 6/84:07 pm
DSM
- JAX
2 stops24h 26m
Multiple Airlines
Deal found 4/16![Multiple Airlines logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/58:23 pm
JAX
- DSM
Nonstop2h 35m
Multiple Airlines
Mon 7/134:40 pm
DSM
- JAX
1 stop21h 30m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/58:23 pm
JAX
- DSM
Nonstop2h 35m
Multiple Airlines
Sun 7/124:57 pm
DSM
- JAX
1 stop26h 53m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/259:21 pm
JAX
- DSM
Nonstop2h 37m
Multiple Airlines
Sat 6/275:06 pm
DSM
- JAX
2 stops20h 34m
Multiple Airlines
Deal found 4/15![Multiple Airlines logo]()
$278
This Kiwi.com deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/259:21 pm
JAX
- DSM
Nonstop2h 37m
Multiple Airlines
Fri 6/265:45 pm
DSM
- JAX
2 stops22h 48m
Multiple Airlines
Deal found 4/19![Multiple Airlines logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/246:28 pm
JAX
- DSM
2 stops28h 15m
Multiple Airlines
Sun 7/263:59 pm
DSM
- JAX
Nonstop2h 34m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/2410:12 am
JAX
- DSM
2 stops29h 18m
Allegiant Air
Sun 7/263:59 pm
DSM
- JAX
Nonstop2h 34m
Allegiant Air
Deal found 4/17![Allegiant Air logo]()
$324
Best flights from Jacksonville to Des MoinesDiscover carefully curated flight deals from Jacksonville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 19, 2026.
Discover carefully curated flight deals from Jacksonville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 19, 2026.
This American Airlines deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:14 pm
JAX
- DSM
1 stop5h 35m
American Airlines
Tue 5/192:24 pm
DSM
- JAX
1 stop8h 07m
American Airlines
Deal found 4/18![American Airlines logo]()
$351
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:00 pm
JAX
- DSM
1 stop7h 24m
United Airlines
Tue 5/125:30 am
DSM
- JAX
1 stop8h 47m
United Airlines
Deal found 4/14![United Airlines logo]()
$351
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:30 am
JAX
- DSM
1 stop4h 35m
Delta
Tue 5/122:33 pm
DSM
- JAX
1 stop6h 53m
Delta
Deal found 4/14![Delta logo]()
$369
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/191:15 pm
JAX
- DSM
2 stops9h 55m
Southwest
Sat 5/305:35 am
DSM
- JAX
2 stops11h 10m
Southwest
Deal found 4/16![Southwest logo]()
$400
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/611:45 am
JAX
- DSM
1 stop6h 17m
Delta
Mon 5/112:33 pm
DSM
- JAX
1 stop5h 03m
Delta
Deal found 4/14![Delta logo]()
$396
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/147:20 am
JAX
- DSM
1 stop6h 10m
United Airlines
Sat 7/186:00 am
DSM
- JAX
1 stop7h 27m
United Airlines
Deal found 4/14![United Airlines logo]()
$427
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/175:20 pm
JAX
- DSM
1 stop6h 00m
Southwest
Mon 7/205:10 am
DSM
- JAX
1 stop5h 50m
Southwest
Deal found 4/17![Southwest logo]()
$427
This Southwest deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/55:20 pm
JAX
- DSM
1 stop6h 00m
Southwest
Mon 6/85:10 am
DSM
- JAX
2 stops10h 05m
Southwest
Deal found 4/16![Southwest logo]()
$431
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/185:05 am
JAX
- DSM
1 stop7h 03m
Delta
Thu 5/216:41 pm
DSM
- JAX
1 stop4h 42m
Delta
Deal found 4/17![Delta logo]()
$434
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/55:25 pm
JAX
- DSM
1 stop6h 20m
United Airlines
Wed 5/138:00 am
DSM
- JAX
2 stops11h 02m
United Airlines
Deal found 4/14![United Airlines logo]()
$446
Last-minute flights from Jacksonville to Des MoinesDiscover last-minute flight deals from Jacksonville to Des Moines. Data last updated April 19, 2026 and is based on user searches.
Discover last-minute flight deals from Jacksonville to Des Moines. Data last updated April 19, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/57:30 am
JAX
- DSM
1 stop4h 35m
Delta
Tue 5/122:33 pm
DSM
- JAX
1 stop6h 53m
Delta
Deal found 4/14![Delta logo]()
$369
This Southwest deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/61:15 pm
JAX
- DSM
2 stops9h 55m
Southwest
Tue 5/125:30 am
DSM
- JAX
2 stops10h 50m
Southwest
Deal found 4/14![Southwest logo]()
$367
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:00 am
JAX
- DSM
1 stop7h 52m
American Airlines
Tue 5/196:00 am
DSM
- JAX
1 stop6h 47m
American Airlines
Deal found 4/14![American Airlines logo]()
$351
This United Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/196:40 pm
JAX
- DSM
1 stop5h 44m
United Airlines
Sat 5/303:01 pm
DSM
- JAX
1 stop7h 19m
United Airlines
Deal found 4/16![United Airlines logo]()
$378
This Southwest deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/261:15 pm
JAX
- DSM
2 stops9h 55m
Southwest
Tue 6/23:10 pm
DSM
- JAX
1 stop5h 05m
Southwest
Deal found 4/17![Southwest logo]()
$389
One-way flights from Jacksonville to Des MoinesSearch for one-way flight options from Jacksonville to Des Moines. Find affordable one-way fares based on user searches. Data last updated April 19, 2026.
Search for one-way flight options from Jacksonville to Des Moines. Find affordable one-way fares based on user searches. Data last updated April 19, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/29:32 pm
JAX
- DSM
Nonstop2h 35m
Allegiant Air
Deal found 4/18![Allegiant Air logo]()
$68
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:30 pm
JAX
- DSM
2 stops20h 16m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$146
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/66:30 pm
JAX
- DSM
2 stops21h 45m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$159
This Kiwi.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/210:33 pm
JAX
- DSM
1 stop18h 17m
Multiple Airlines
Deal found 4/18![Multiple Airlines logo]()
$173
This United Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/68:15 am
JAX
- DSM
1 stop9h 00m
United Airlines
Deal found 4/14![United Airlines logo]()
$176
This American Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1211:46 am
JAX
- DSM
2 stops8h 47m
American Airlines
Deal found 4/17![American Airlines logo]()
$181
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/212:08 pm
JAX
- DSM
2 stops32h 01m
Allegiant Air
Deal found 4/15![Allegiant Air logo]()
$184
This Delta deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/58:35 am
JAX
- DSM
1 stop6h 20m
Delta
Deal found 4/14![Delta logo]()
$185
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/129:03 pm
JAX
- DSM
3 stops43h 12m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$189
This American Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/217:00 am
JAX
- DSM
1 stop7h 10m
American Airlines
Deal found 4/15![American Airlines logo]()
$203
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/238:34 pm
JAX
- DSM
3 stops27h 08m
Allegiant Air
Deal found 4/15![Allegiant Air logo]()
$205
Find flight deals from Jacksonville to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Jacksonville (JAX) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 19, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $116 (Kiwi.com) |
One-way from | $68 (Kiwi.com) |
Popular in | March |
Cheapest in | September |
Average price | $416 |
Cheapflights Fare Finder
Customize your flight search to find flights from Jacksonville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 19, 2026.
Use the filters below to find and compare flights from Jacksonville to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
JacksonvilleDes Moines
JAX - DSM
JAXDSM
Jacksonville
Tue 5/12
7:14 pm-11:49 pm
1 stop5h 35m
Des Moines
Tue 5/19
2:24 pm-11:31 pm
1 stop8h 07m
$351
JacksonvilleDes Moines
JAX - DSM
JAXDSM
Jacksonville
Wed 5/6
5:00 pm-11:24 pm
1 stop7h 24m
Des Moines
Tue 5/12
5:30 am-3:17 pm
1 stop8h 47m
$351
JacksonvilleDes Moines
JAX - DSM
JAXDSM
Jacksonville
Tue 5/5
7:30 am-11:05 am
1 stop4h 35m
Des Moines
Tue 5/12
2:33 pm-10:26 pm
1 stop6h 53m
$369
Quickest round-trip
JacksonvilleDes Moines
JAX - DSM
JAXDSM
Jacksonville
Wed 5/6
11:45 am-5:02 pm
1 stop6h 17m
Des Moines
Mon 5/11
2:33 pm-8:36 pm
1 stop5h 03m
$396
JacksonvilleDes Moines
JAX - DSM
JAXDSM
Jacksonville
Tue 5/19
1:15 pm-10:10 pm
2 stops9h 55m
Des Moines
Sat 5/30
5:35 am-5:45 pm
2 stops11h 10m
$400
JacksonvilleDes Moines
JAX - DSM
JAXDSM
Jacksonville
Tue 7/14
7:20 am-12:30 pm
1 stop6h 10m
Des Moines
Sat 7/18
6:00 am-2:27 pm
1 stop7h 27m
$427
JacksonvilleDes Moines
JAX - DSM
JAXDSM
Jacksonville
Fri 7/17
5:20 pm-10:20 pm
1 stop6h 00m
Des Moines
Mon 7/20
5:10 am-12:00 pm
1 stop5h 50m
$427
JacksonvilleDes Moines
JAX - DSM
JAXDSM
Jacksonville
Fri 6/5
5:20 pm-10:20 pm
1 stop6h 00m
Des Moines
Mon 6/8
5:10 am-4:15 pm
2 stops10h 05m
$431
JacksonvilleDes Moines
JAX - DSM
JAXDSM
Jacksonville
Mon 5/18
5:05 am-11:08 am
1 stop7h 03m
Des Moines
Thu 5/21
6:41 pm-12:23 am
1 stop4h 42m
$434
JacksonvilleDes Moines
JAX - DSM
JAXDSM
Jacksonville
Tue 5/5
5:25 pm-10:45 pm
1 stop6h 20m
Des Moines
Wed 5/13
8:00 am-8:02 pm
2 stops11h 02m
$446
Showing 1-10 of 20 resultsSorted by cheapest first
Compare providers for flights from Jacksonville to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Jacksonville to Des Moines in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Jacksonville-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Jacksonville-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Jacksonville-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Jacksonville-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Jacksonville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Jacksonville to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Jacksonville with our price prediction graph.
JAX-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Jacksonville to Des Moines
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated April 19, 2026.
Read through reviews of airlines operating flights from Jacksonville to Des Moines, such as Delta,United Airlines, andAllegiant Air. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.9
Food
7.2
Overall
7.9
Boarding
8.1
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
6.0
Goodpilar,May 2025
RSW - ATL
Comfort
7.9
Food
7.2
Overall
7.9
Boarding
8.1
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
6.0
Goodpilar,May 2025
RSW - ATL
Comfort
7.9
Food
7.2
Overall
7.9
Boarding
8.1
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
6.0
Goodpilar,May 2025
RSW - ATL
Comfort
7.9
Food
7.2
Overall
7.9
Boarding
8.1
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
6.0
Goodpilar,May 2025
RSW - ATL
Comfort
7.9
Food
7.2
Overall
7.9
Boarding
8.1
Entertainment
7.8
Crew
8.5
Reviews
1 / 20
6.0
Goodpilar,May 2025
RSW - ATL
Related info for your journey
Find useful and relevant information for your journey from Jacksonville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Johnston
Ames
Clive
Boone
West Des Moines
Ankeny
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Jacksonville and Des Moines flights
Browse other Jacksonville and Des Moines flight options. Last updated on April 19, 2026.
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Browse through other flights departing from Jacksonville. Flights are based on user searches made on Cheapflights and were last updated on April 19, 2026.
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Top 4 airlines flying from Jacksonville to Des Moines
Discover the top 4 airlines that operate flights from Jacksonville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$82 | Average$92 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$130 | Average$454 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$286 | Average$385 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$351 | Average$426 | FlexibilityNo cancel fee | On-time69% |