$141+ Cheap flights from Jacksonville to Des Moines (JAX - DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/17. Fares are subject to change and may not be available on all flights or dates of travel.
JAX — DSM
Nov 7 — Nov 141
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Jacksonville to Des Moines
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Cheapest flights from Jacksonville to Des MoinesExplore the most affordable flight options available from Jacksonville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 8, 2026.
Explore the most affordable flight options available from Jacksonville to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/213:55 pm -
1 stop26h 07m
Mon 10/268:25 pm -
2 stops44h 43m
Deal found 10/6![Multiple Airlines logo]()
$269
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:10 am -
1 stop4h 34m
Wed 12/22:58 pm -
1 stop5h 57m
Deal found 10/6![Delta logo]()
$281
This Southwest deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:35 am -
2 stops8h 40m
Wed 12/23:30 pm -
1 stop5h 40m
Deal found 10/6![Southwest logo]()
$286
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:00 am -
1 stop6h 48m
Mon 11/168:07 am -
1 stop7h 18m
Deal found 10/8![American Airlines logo]()
$320
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:45 pm -
2 stops6h 20m
Mon 11/163:30 pm -
1 stop5h 40m
Deal found 10/8![Southwest logo]()
$326
This Delta deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:00 am -
1 stop5h 49m
Mon 12/216:43 pm -
1 stop4h 13m
Deal found 10/7![Delta logo]()
$335
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2411:32 am -
1 stop27h 27m
Sun 10/256:37 pm -
1 stop13h 08m
Deal found 10/5![Multiple Airlines logo]()
$373
This Southwest deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/293:00 pm -
2 stops9h 15m
Mon 11/24:25 pm -
2 stops6h 15m
Deal found 10/6![Southwest logo]()
$379
This American Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/167:30 am -
2 stops7h 05m
Mon 12/214:01 pm -
1 stop5h 35m
Deal found 10/6![American Airlines logo]()
$382
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2411:32 am -
1 stop27h 27m
Mon 10/268:25 pm -
2 stops20h 43m
Deal found 10/5![Multiple Airlines logo]()
$396
Best flights from Jacksonville to Des MoinesDiscover carefully curated flight deals from Jacksonville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 8, 2026.
Discover carefully curated flight deals from Jacksonville to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 8, 2026.
This Southwest deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:35 am -
2 stops8h 40m
Wed 12/23:30 pm -
1 stop5h 40m
Deal found 10/6![Southwest logo]()
$286
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3012:35 pm -
1 stop5h 52m
Sun 11/19:55 am -
1 stop7h 06m
Deal found 10/7![United Airlines logo]()
$408
This Delta deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/235:49 pm -
1 stop5h 44m
Mon 10/266:54 pm -
1 stop4h 02m
Deal found 10/5![Delta logo]()
$415
This American Airlines deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:50 pm -
1 stop7h 36m
Sun 11/83:31 pm -
1 stop5h 59m
Deal found 10/4![American Airlines logo]()
$447
This Kiwi.com deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:03 pm -
2 stops25h 32m
Sun 11/812:25 pm -
1 stop19h 20m
Deal found 10/4![Multiple Airlines logo]()
$447
This Southwest deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:35 am -
2 stops8h 40m
Wed 12/27:00 am -
2 stops9h 00m
Deal found 10/5![Southwest logo]()
$291
This United Airlines deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/308:00 am -
1 stop9h 07m
Mon 11/21:27 pm -
1 stop7h 04m
Deal found 10/6![United Airlines logo]()
$430
Last-minute flights from Jacksonville to Des MoinesDiscover last-minute flight deals from Jacksonville to Des Moines. Data last updated October 8, 2026 and is based on user searches.
Discover last-minute flight deals from Jacksonville to Des Moines. Data last updated October 8, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/213:55 pm -
1 stop26h 07m
Mon 10/268:25 pm -
2 stops44h 43m
Deal found 10/6![Multiple Airlines logo]()
$269
This Delta deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:18 am -
1 stop4h 24m
Tue 10/2710:22 am -
1 stop6h 19m
Deal found 10/5![Delta logo]()
$409
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2411:32 am -
1 stop27h 27m
Sun 10/256:37 pm -
1 stop13h 08m
Deal found 10/5![Multiple Airlines logo]()
$373
This Kiwi.com deal was found by Cheapflights users on 10/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2411:32 am -
1 stop27h 27m
Mon 10/268:25 pm -
2 stops20h 43m
Deal found 10/5![Multiple Airlines logo]()
$396
This Southwest deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/293:00 pm -
2 stops9h 15m
Mon 11/24:25 pm -
2 stops6h 15m
Deal found 10/6![Southwest logo]()
$379
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3012:35 pm -
1 stop5h 52m
Sun 11/19:55 am -
1 stop7h 06m
Deal found 10/7![United Airlines logo]()
$408
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:00 am -
1 stop6h 48m
Mon 11/168:07 am -
1 stop7h 18m
Deal found 10/8![American Airlines logo]()
$320
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/65:45 pm -
2 stops6h 20m
Mon 11/163:30 pm -
1 stop5h 40m
Deal found 10/8![Southwest logo]()
$326
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:10 am -
1 stop4h 34m
Wed 12/22:58 pm -
1 stop5h 57m
Deal found 10/6![Delta logo]()
$281
This Southwest deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:35 am -
2 stops8h 40m
Wed 12/23:30 pm -
1 stop5h 40m
Deal found 10/6![Southwest logo]()
$286
One-way flights from Jacksonville to Des MoinesSearch for one-way flight options from Jacksonville to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 8, 2026.
Search for one-way flight options from Jacksonville to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 8, 2026.
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1712:00 pm -
1 stop5h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Delta logo]()
$141
This Kiwi.com deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/177:03 pm -
2 stops46h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![Multiple Airlines logo]()
$166
This Kiwi.com deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/143:55 pm -
1 stop25h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/8![Multiple Airlines logo]()
$179
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/182:55 pm -
2 stops27h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Multiple Airlines logo]()
$184
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:46 pm -
3 stops36h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Multiple Airlines logo]()
$189
This Kiwi.com deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1711:32 am -
1 stop28h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/8![Multiple Airlines logo]()
$193
This Delta deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/185:00 am -
1 stop6h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Delta logo]()
$195
This Kiwi.com deal was found by Cheapflights users on 10/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/183:00 pm -
1 stop9h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/4![Multiple Airlines logo]()
$206
This Kiwi.com deal was found by Cheapflights users on 10/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/137:46 pm -
2 stops46h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/6![Multiple Airlines logo]()
$216
This United Airlines deal was found by Cheapflights users on 10/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/18:00 am -
1 stop9h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/7![United Airlines logo]()
$229
Find flight deals from Jacksonville to Des Moines
Discover tips and strategies to find the most affordable flight options for your journey from Jacksonville (JAX) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 8, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $269 (Kiwi.com) |
One-way from | $141 (Delta) |
Popular in | December |
Cheapest in | November |
Average price | $410 |
Cheapflights Fare Finder
Customize your flight search to find flights from Jacksonville to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 8, 2026.
Use the filters below to find and compare flights from Jacksonville to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
JacksonvilleDes Moines
JAX Jacksonville - DSM Des Moines
JAXDSM
Jacksonville
Thu 12/17
12:00 pm-4:49 pm
1 stop5h 49m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$141
JacksonvilleDes Moines
JAX Jacksonville - DSM Des Moines
JAXDSM
Jacksonville
Sat 12/19
5:00 am-10:49 am
1 stop6h 49m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$195
JacksonvilleDes Moines
JAX Jacksonville - DSM Des Moines
JAXDSM
Jacksonville
Fri 12/18
5:00 am-10:49 am
1 stop6h 49m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$195
JacksonvilleDes Moines
JAX Jacksonville - DSM Des Moines
JAXDSM
Jacksonville
Sun 10/18
3:00 pm-11:10 pm
1 stop9h 10m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$206
JacksonvilleDes Moines
JAX Jacksonville - DSM Des Moines
JAXDSM
Jacksonville
Wed 10/14
7:46 pm-4:52 pm
2 stops22h 06m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$224
JacksonvilleDes Moines
JAX Jacksonville - DSM Des Moines
JAXDSM
Jacksonville
Sat 10/17
7:46 pm-2:42 pm
2 stops19h 56m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$264
JacksonvilleDes Moines
JAX Jacksonville - DSM Des Moines
JAXDSM
Jacksonville
Wed 11/18
6:35 am-2:15 pm
2 stops8h 40m
Des Moines
Wed 12/2
3:30 pm-10:10 pm
1 stop5h 40m
$286
JacksonvilleDes Moines
JAX Jacksonville - DSM Des Moines
JAXDSM
Jacksonville
Wed 11/11
6:35 am-2:15 pm
2 stops8h 40m
Des Moines
Wed 12/2
7:00 am-5:00 pm
2 stops9h 00m
$291
JacksonvilleDes Moines
JAX Jacksonville - DSM Des Moines
JAXDSM
Jacksonville
Tue 10/13
5:06 pm-7:38 am
3 stops39h 32m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$298
JacksonvilleDes Moines
JAX Jacksonville - DSM Des Moines
JAXDSM
Jacksonville
Tue 10/20
9:00 am-3:11 pm
1 stop7h 11m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$355
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Jacksonville to Des Moines
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Jacksonville to Des Moines in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Jacksonville-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Jacksonville-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Jacksonville-Des Moines flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Jacksonville-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Jacksonville-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Jacksonville to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Jacksonville with our price prediction graph.
JAX-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Jacksonville to Des Moines
Reviews of airlines servicing Des Moines
Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated October 8, 2026.
Read through reviews of airlines operating flights from Jacksonville to Des Moines, such as Delta,United Airlines, andAllegiant Air. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Entertainment
7.8
Overall
7.8
Food
7.2
Crew
8.5
Comfort
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Boarding
8.1
Entertainment
7.8
Overall
7.8
Food
7.2
Crew
8.5
Comfort
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Boarding
8.1
Entertainment
7.8
Overall
7.8
Food
7.2
Crew
8.5
Comfort
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Boarding
8.1
Entertainment
7.8
Overall
7.8
Food
7.2
Crew
8.5
Comfort
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Boarding
8.1
Entertainment
7.8
Overall
7.8
Food
7.2
Crew
8.5
Comfort
7.8
Reviews
1 / 20
8.0
ExcellentJorge,Aug 2026
TPA - ATL
Related info for your journey
Find useful and relevant information for your journey from Jacksonville to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
West Des Moines
Ames
Johnston
Boone
Norwalk
Ankeny
Browse thousands of different options on Cheapflights for your next trip
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Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 8, 2026.
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Jacksonville and Des Moines flights
Browse other Jacksonville and Des Moines flight options. Last updated on October 8, 2026.
Other flights from Jacksonville
Browse through other flights departing from Jacksonville. Flights are based on user searches made on Cheapflights and were last updated on October 8, 2026.
Popular flight searches
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Top 4 airlines flying from Jacksonville to Des Moines
Discover the top 4 airlines that operate flights from Jacksonville to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$40 | Average$110 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$202 | Average$507 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$286 | Average$406 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$296 | Average$426 | FlexibilityNo cancel fee | On-time69% |