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Des Moines

$279+ Cheap flights from Harrisburg to Des Moines (MDT - DSM)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/30. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — DSM
ago. 23 — ago. 301
sáb. 8/23
sáb. 8/30
1 adult, Economy
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Cheap flight deals from Harrisburg to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated agosto 18, 2025.

Round-trip from

$279
(American Airlines)

Popular in

February

Cheapest in

April

Average price

$363
From Harrisburg to Des Moines
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($54 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2025
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Find flight deals from Harrisburg to Des Moines

Cheapest flights from Harrisburg to Des Moines
Explore the most affordable flight options available from Harrisburg to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 18, 2025.

This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/173:30 pmMDT - DSM
1 stop5h 41mAmerican Airlines
dom. 10/195:00 amDSM - MDT
1 stop4h 57mAmerican Airlines
Deal found 8/18$279
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/215:48 pmMDT - DSM
1 stop5h 02mUnited Airlines
sáb. 11/13:15 pmDSM - MDT
1 stop4h 49mUnited Airlines
Deal found 8/16$319
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/216:43 amMDT - DSM
1 stop5h 10mAmerican Airlines
lun. 8/253:21 pmDSM - MDT
1 stop7h 35mAmerican Airlines
Deal found 8/17$324
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/164:56 pmMDT - DSM
1 stop5h 49mAmerican Airlines
jue. 8/217:00 amDSM - MDT
1 stop5h 13mAmerican Airlines
Deal found 8/16$339
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/46:00 amMDT - DSM
1 stop5h 40mDelta
dom. 10/195:56 pmDSM - MDT
1 stop4h 04mDelta
Deal found 8/16$358
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/166:00 amMDT - DSM
1 stop5h 05mDelta
dom. 10/195:56 pmDSM - MDT
1 stop4h 04mDelta
Deal found 8/18$388
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/2112:28 pmMDT - DSM
1 stop5h 17mDelta
lun. 8/2511:23 amDSM - MDT
2 stops10h 56mDelta
Deal found 8/18$409
This Kiwi.com deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/168:21 pmMDT - DSM
1 stop13h 09mMultiple Airlines
dom. 10/1910:41 amDSM - MDT
2 stops29h 31mMultiple Airlines
Deal found 8/18$411
This Delta deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 8/1612:28 pmMDT - DSM
2 stops11h 15mDelta
jue. 8/216:00 amDSM - MDT
1 stop4h 42mDelta
Deal found 8/15$424

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 18, 2025.
Use the filters below to find and compare flights from Harrisburg to Des Moines that are best for you.

Fly from

Harrisburg

Fly to

Des Moines

Route

Depart

Return

Price

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

jue. 10/30

6:00 am-10:05 am

1 stop5h 05m

Des Moines

dom. 11/2

2:13 pm-11:08 pm

1 stop7h 55m

$279

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

vie. 10/17

3:30 pm-8:11 pm

1 stop5h 41m

Des Moines

dom. 10/19

5:00 am-10:57 am

1 stop4h 57m

$279

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

jue. 8/28

6:10 am-9:37 am

1 stop4h 27m

Des Moines

lun. 9/1

5:55 pm-11:19 pm

1 stop4h 24m

$284

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

mar. 10/21

5:48 pm-9:50 pm

1 stop5h 02m

Des Moines

sáb. 11/1

3:15 pm-9:04 pm

1 stop4h 49m

$319

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

vie. 8/29

5:00 am-8:37 am

1 stop4h 37m

Des Moines

mar. 9/2

8:17 am-2:01 pm

1 stop4h 44m

$324

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

vie. 8/29

1:55 pm-5:24 pm

1 stop4h 29m

Des Moines

lun. 9/1

5:00 am-11:03 am

1 stop5h 03m

$324

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

vie. 9/12

6:30 pm-11:06 pm

1 stop5h 36m

Des Moines

dom. 9/14

5:00 am-11:01 am

1 stop5h 01m

$339

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

sáb. 10/4

6:00 am-10:40 am

1 stop5h 40m

Des Moines

dom. 10/19

5:56 pm-11:00 pm

1 stop4h 04m

$358

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

mar. 9/2

2:24 pm-11:41 pm

2 stops10h 17m

Des Moines

sáb. 9/6

11:35 am-4:54 pm

1 stop4h 19m

$374

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

sáb. 8/30

6:10 am-9:37 am

1 stop4h 27m

$345

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/17

Best time to book a flight from Harrisburg to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to Des Moines

What is the cheapest month to book a flight from Harrisburg to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Harrisburg to Des Moines (average of $336). Flying from Harrisburg to Des Moines in June is currently the most expensive (average of $401). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MDT to DSM?

Find hourly flight availability from Harrisburg to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated agosto 18, 2025.

When flying from Harrisburg to Des Moines, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 15% versus a flight in the morning.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated agosto 18, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Harrisburg to Des Moines to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,981 reviews

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,981 reviews
Delta
8.0
Very good
7,981 reviews

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,925 reviews
Delta
8.0
Very good
7,981 reviews

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,981 reviews

Crew

8.5

Food

7.3

Overall

8.0

Boarding

8.2

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Harrisburg to Des Moines?

    Delta, American Airlines, and United Airlines can get you from Harrisburg to Des Moines in just under 5h 02m. Your travel time can differ by up to 39m. The distance from Harrisburg to Des Moines is about 886 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Harrisburg to Des Moines round-trip?

    Cheapflights users have booked flights from Harrisburg to Des Moines round-trip from $248. Other airlines that can offer you cheap pricing are American Airlines, from $253, and Delta, from $278. You may be able to fly from Harrisburg to Des Moines for 44% less than the average price by searching for these airlines.

  • Can I find deals for flights from Harrisburg to Des Moines that include hotel bookings?

    Yes. In addition to deals on Harrisburg to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to Des Moines.

  • Can I find deals for business class flights from Harrisburg to Des Moines?

    Yes. Cheapflights offers flight deals from Harrisburg to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Harrisburg to Des Moines (average of $336). Flying from Harrisburg to Des Moines in June is currently the most expensive (average of $401). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Ames
Johnston
Boone
West Des Moines
Ankeny

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Harrisburg to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Harrisburg to Des Moines

Discover the top 3 airlines that operate flights from Harrisburg to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$248Average$443FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$253Average$377FlexibilityNo cancel feeOn-time71%
DeltaCheapest$278Average$383FlexibilityNo cancel feeOn-timeN/A

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