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Des Moines

$181+ Cheap flights from Harrisburg to Des Moines (MDT - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/27. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — DSM
Mar 16 — Mar 231
Mon 3/16
Mon 3/23
1 adult, Economy
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Cheap flight deals from Harrisburg to Des Moines

Cheapest flights from Harrisburg to Des Moines
Explore the most affordable flight options available from Harrisburg to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 14, 2026.

This Frontier deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1210:13 pm
MDT
-
DSM
1 stop12h 17m
Frontier
Tue 3/1710:40 am
DSM
-
MDT
1 stop6h 12m
Frontier
Deal found 2/13$189
This Frontier deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/1410:18 pm
MDT
-
DSM
1 stop12h 27m
Frontier
Tue 3/1710:40 am
DSM
-
MDT
1 stop6h 12m
Frontier
Deal found 2/12$216
This Delta deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/124:40 pm
MDT
-
DSM
1 stop5h 05m
Delta
Wed 3/185:20 pm
DSM
-
MDT
1 stop5h 21m
Delta
Deal found 2/13$269
This United Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/16:29 am
MDT
-
DSM
1 stop5h 24m
United Airlines
Sat 3/72:04 pm
DSM
-
MDT
1 stop6h 01m
United Airlines
Deal found 2/12$274
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/133:34 pm
MDT
-
DSM
1 stop7h 25m
American Airlines
Wed 3/185:00 am
DSM
-
MDT
1 stop6h 01m
American Airlines
Deal found 2/12$279
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/135:06 pm
MDT
-
DSM
1 stop5h 53m
American Airlines
Tue 3/171:48 pm
DSM
-
MDT
2 stops8h 11m
American Airlines
Deal found 2/11$284
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/276:31 pm
MDT
-
DSM
1 stop5h 03m
American Airlines
Sun 3/296:40 am
DSM
-
MDT
1 stop4h 39m
American Airlines
Deal found 2/11$289
This United Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:30 am
MDT
-
DSM
1 stop4h 50m
United Airlines
Mon 10/263:15 pm
DSM
-
MDT
1 stop5h 05m
United Airlines
Deal found 2/12$291
This American Airlines deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/125:06 pm
MDT
-
DSM
1 stop5h 53m
American Airlines
Wed 3/181:48 pm
DSM
-
MDT
2 stops8h 11m
American Airlines
Deal found 2/12$308
This Delta deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:10 am
MDT
-
DSM
1 stop4h 36m
Delta
Wed 3/185:20 pm
DSM
-
MDT
1 stop5h 21m
Delta
Deal found 2/11$319

Find flight deals from Harrisburg to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 14, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$189
(Frontier)

One-way from

$181
(Kiwi.com)

Popular in

July

Cheapest in

April

Average price

$504
Provider with most accurate pricing for Harrisburg-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Harrisburg-Des Moines flights.
Search Deals
From Harrisburg to Des Moines
Search Deals
One-way flight from Harrisburg to Des Moines
Search Deals
Highest demand for flights based on searches. 27% potential increase in price ($162 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 14, 2026.
Use the filters below to find and compare flights from Harrisburg to Des Moines that are best for you.

Fly from

Harrisburg

Fly to

Des Moines

Route

Depart

Return

Price

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Thu 3/12

10:13 pm-9:30 am

1 stop12h 17m

Des Moines

Tue 3/17

10:40 am-5:52 pm

1 stop6h 12m

$189

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Thu 3/12

4:40 pm-8:45 pm

1 stop5h 05m

Des Moines

Wed 3/18

5:20 pm-11:41 pm

1 stop5h 21m

$269

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Thu 3/12

5:06 pm-9:59 pm

1 stop5h 53m

Des Moines

Wed 3/18

1:48 pm-10:59 pm

2 stops8h 11m

$274

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Sun 3/1

6:29 am-10:53 am

1 stop5h 24m

Des Moines

Sat 3/7

2:04 pm-9:05 pm

1 stop6h 01m

$274

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Fri 3/27

6:31 pm-10:34 pm

1 stop5h 03m

Des Moines

Sun 3/29

6:40 am-12:19 pm

1 stop4h 39m

$289

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Fri 3/13

3:34 pm-9:59 pm

1 stop7h 25m

Des Moines

Wed 3/18

1:48 pm-10:59 pm

2 stops8h 11m

$318

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Fri 3/13

6:10 am-9:46 am

1 stop4h 36m

Des Moines

Tue 3/17

10:28 am-3:52 pm

1 stop4h 24m

$319

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Sat 3/14

6:10 am-9:59 am

1 stop4h 49m

Des Moines

Wed 3/18

5:20 pm-11:41 pm

1 stop5h 21m

$319

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Fri 3/13

6:10 am-9:46 am

1 stop4h 36m

Des Moines

Wed 3/18

5:20 pm-11:41 pm

1 stop5h 21m

$319

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Wed 8/12

12:25 pm-5:42 pm

1 stop6h 17m

Des Moines

Sun 8/16

5:45 am-2:09 pm

1 stop7h 24m

$369

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/12

Showing 1-10 of 20 results
1
2

Compare providers for flights from Harrisburg to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to Des Moines in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Harrisburg-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Harrisburg-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Harrisburg-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Harrisburg-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Harrisburg to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to Des Moines

What is the cheapest month to book a flight from Harrisburg to Des Moines?

Currently, July is the cheapest month in which you can book a flight from Harrisburg to Des Moines (average of $145). Flying from Harrisburg to Des Moines in February is currently the most expensive (average of $355). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated February 14, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Harrisburg to Des Moines to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,203 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Food

7.2

Entertainment

7.8

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,203 reviews
Delta
7.9
Good
8,203 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Food

7.2

Entertainment

7.8

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,289 reviews
Delta
7.9
Good
8,203 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Food

7.2

Entertainment

7.8

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,288 reviews
Delta
7.9
Good
8,203 reviews

Comfort

7.9

Overall

7.9

Crew

8.5

Food

7.2

Entertainment

7.8

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Harrisburg to Des Moines?

    Frontier, Delta, and American Airlines can get you from Harrisburg to Des Moines in just under 5h 05m. Your travel time can differ by up to 7h 12m. The distance from Harrisburg to Des Moines is about 886 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Harrisburg to Des Moines round-trip?

    Cheapflights users have booked flights from Harrisburg to Des Moines round-trip from $248. Other airlines that can offer you cheap pricing are United Airlines, from $248, and Delta, from $278. You may be able to fly from Harrisburg to Des Moines for 40% less than the average price by searching for these airlines.

  • Can I find deals for flights from Harrisburg to Des Moines that include hotel bookings?

    Yes. In addition to deals on Harrisburg to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to Des Moines.

  • Can I find deals for business class flights from Harrisburg to Des Moines?

    Yes. Cheapflights offers flight deals from Harrisburg to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to Des Moines?

    Currently, July is the cheapest month in which you can book a flight from Harrisburg to Des Moines (average of $145). Flying from Harrisburg to Des Moines in February is currently the most expensive (average of $355). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

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Alternative routes for Harrisburg to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Harrisburg to Des Moines

Discover the top 3 airlines that operate flights from Harrisburg to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 14, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$377FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$248Average$353FlexibilityNo cancel feeOn-time69%
DeltaCheapest$278Average$378FlexibilityNo cancel feeOn-timeN/A

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