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Des Moines

$151+ Cheap flights from Harrisburg to Des Moines (MDT - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/21. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — DSM
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
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Find flight deals from Harrisburg to Des Moines

Cheapest flights from Harrisburg to Des Moines
Explore the most affordable flight options available from Harrisburg to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/36:25 pmMDT - DSM
1 stop5h 05mDelta
Mon 11/175:52 pmDSM - MDT
1 stop4h 12mDelta
Deal found 10/15$254
This Delta deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/16:10 amMDT - DSM
1 stop4h 09mDelta
Wed 11/55:56 pmDSM - MDT
1 stop4h 04mDelta
Deal found 10/16$259
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/18:15 amMDT - DSM
2 stops8h 58mUnited Airlines
Wed 11/511:26 amDSM - MDT
1 stop6h 49mUnited Airlines
Deal found 10/16$264
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/218:15 amMDT - DSM
1 stop7h 04mUnited Airlines
Mon 11/243:15 pmDSM - MDT
1 stop4h 49mUnited Airlines
Deal found 10/15$265
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/86:30 amMDT - DSM
1 stop5h 12mUnited Airlines
Tue 11/1111:26 amDSM - MDT
1 stop6h 49mUnited Airlines
Deal found 10/16$294
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/36:15 amMDT - DSM
2 stops9h 04mUnited Airlines
Mon 11/171:05 pmDSM - MDT
1 stop5h 10mUnited Airlines
Deal found 10/15$304
This United Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/256:30 amMDT - DSM
1 stop5h 00mUnited Airlines
Fri 11/2811:26 amDSM - MDT
1 stop4h 27mUnited Airlines
Deal found 10/16$319

Cheap flight deals from Harrisburg to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$249
(Delta)

One-way from

$151
(Kiwi.com)

Popular in

January

Cheapest in

April

Average price

$323
Provider with most accurate pricing for Harrisburg-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Harrisburg-Des Moines flights.
Search Deals
From Harrisburg to Des Moines
Search Deals
One-way flight from Harrisburg to Des Moines
Search Deals
Highest demand for flights based on searches. 20% potential increase in price ($113 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Harrisburg to Des Moines that are best for you.

Fly from

Harrisburg

Fly to

Des Moines

Route

Depart

Return

Price

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Mon 11/3

6:25 pm-10:30 pm

1 stop5h 05m

Des Moines

Mon 11/17

5:52 pm-11:04 pm

1 stop4h 12m

$254

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Sat 11/1

6:10 am-9:19 am

1 stop4h 09m

Des Moines

Wed 11/5

5:56 pm-11:00 pm

1 stop4h 04m

$259

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Sat 11/1

8:15 am-4:13 pm

2 stops8h 58m

Des Moines

Wed 11/5

11:26 am-7:15 pm

1 stop6h 49m

$264

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Fri 11/21

6:30 am-10:30 am

1 stop5h 00m

Des Moines

Mon 11/24

3:15 pm-9:04 pm

1 stop4h 49m

$267

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Sat 2/21

6:10 am-9:30 am

1 stop4h 20m

Des Moines

Tue 2/24

5:15 pm-11:40 pm

1 stop5h 25m

$279

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Mon 11/3

6:15 am-2:19 pm

2 stops9h 04m

Des Moines

Mon 11/17

1:05 pm-7:15 pm

1 stop5h 10m

$304

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Tue 11/25

6:30 am-10:30 am

1 stop5h 00m

Des Moines

Fri 11/28

11:26 am-4:53 pm

1 stop4h 27m

$319

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Fri 11/21

8:35 pm-9:48 pm

1 stop26h 13m

$151

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Sun 11/16

11:43 am-9:33 pm

1 stop10h 50m

$217

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Fri 11/21

6:15 am-2:19 pm

2 stops9h 04m

$244

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/15

Showing 1-10 of 11 results
1
2

Compare providers for flights from Harrisburg to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to Des Moines in October.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Harrisburg-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Harrisburg-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Harrisburg-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Harrisburg-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Harrisburg to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to Des Moines

What is the cheapest month to book a flight from Harrisburg to Des Moines?

Currently, July is the cheapest month in which you can book a flight from Harrisburg to Des Moines (average of $148). Flying from Harrisburg to Des Moines in January is currently the most expensive (average of $400). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MDT to DSM?

Find hourly flight availability from Harrisburg to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 16, 2025.

When flying from Harrisburg to Des Moines, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 35% versus a flight at noon.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated October 16, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Harrisburg to Des Moines to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,984 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
8.0
Very good
7,984 reviews
Delta
8.0
Very good
7,984 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
8,982 reviews
Delta
8.0
Very good
7,984 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,043 reviews
Delta
8.0
Very good
7,984 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Boarding

8.2

Food

7.3

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Harrisburg to Des Moines?

    Delta and United Airlines can get you from Harrisburg to Des Moines in just under 5h 05m. Your travel time can differ by up to 3h 53m. The distance from Harrisburg to Des Moines is about 886 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Harrisburg to Des Moines round-trip?

    Cheapflights users have booked flights from Harrisburg to Des Moines round-trip from $248. Other airlines that can offer you cheap pricing are United Airlines, from $248, and Delta, from $278. You may be able to fly from Harrisburg to Des Moines for 44% less than the average price by searching for these airlines.

  • Can I find deals for flights from Harrisburg to Des Moines that include hotel bookings?

    Yes. In addition to deals on Harrisburg to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to Des Moines.

  • Can I find deals for business class flights from Harrisburg to Des Moines?

    Yes. Cheapflights offers flight deals from Harrisburg to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to Des Moines?

    Currently, July is the cheapest month in which you can book a flight from Harrisburg to Des Moines (average of $148). Flying from Harrisburg to Des Moines in January is currently the most expensive (average of $400). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Alternative routes for Harrisburg to Des Moines

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Top 3 airlines flying from Harrisburg to Des Moines

Discover the top 3 airlines that operate flights from Harrisburg to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$248Average$369FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$248Average$373FlexibilityNo cancel feeOn-time71%
DeltaCheapest$278Average$378FlexibilityNo cancel feeOn-timeN/A

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