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Des Moines

$279+ Cheap flights from Harrisburg to Des Moines (MDT - DSM)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/12. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — DSM
Mar 30 — Apr 61
Mon 3/30
Mon 4/6
1 adult, Economy
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Cheap flight deals from Harrisburg to Des Moines

Cheapest flights from Harrisburg to Des Moines
Explore the most affordable flight options available from Harrisburg to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 28, 2026.

This Delta deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/126:10 am
MDT
-
DSM
1 stop4h 36m
Delta
Wed 3/185:20 pm
DSM
-
MDT
1 stop5h 21m
Delta
Deal found 2/26$279
This American Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:53 pm
MDT
-
DSM
1 stop6h 06m
American Airlines
Tue 6/236:29 pm
DSM
-
MDT
1 stop4h 39m
American Airlines
Deal found 2/26$337
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/56:31 pm
MDT
-
DSM
1 stop6h 09m
American Airlines
Sun 3/85:00 am
DSM
-
MDT
1 stop6h 19m
American Airlines
Deal found 2/25$339
This United Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/225:47 pm
MDT
-
DSM
1 stop4h 40m
United Airlines
Tue 5/511:40 am
DSM
-
MDT
2 stops10h 48m
United Airlines
Deal found 2/24$344
This United Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/135:40 pm
MDT
-
DSM
1 stop5h 00m
United Airlines
Tue 3/173:28 pm
DSM
-
MDT
1 stop4h 37m
United Airlines
Deal found 2/26$349
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/286:31 pm
MDT
-
DSM
1 stop4h 48m
American Airlines
Mon 3/91:48 pm
DSM
-
MDT
2 stops8h 11m
American Airlines
Deal found 2/25$359
This Delta deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/286:00 am
MDT
-
DSM
1 stop5h 09m
Delta
Mon 3/95:47 pm
DSM
-
MDT
1 stop4h 03m
Delta
Deal found 2/25$369
This American Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/126:00 am
MDT
-
DSM
1 stop18h 40m
American Airlines
Wed 3/181:48 pm
DSM
-
MDT
2 stops8h 11m
American Airlines
Deal found 2/26$372
This American Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/286:53 pm
MDT
-
DSM
1 stop6h 06m
American Airlines
Sun 5/316:02 am
DSM
-
MDT
1 stop6h 53m
American Airlines
Deal found 2/24$374
This United Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:47 pm
MDT
-
DSM
1 stop4h 40m
United Airlines
Thu 4/97:04 pm
DSM
-
MDT
1 stop4h 23m
United Airlines
Deal found 2/26$407
This American Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:53 pm
MDT
-
DSM
1 stop6h 06m
American Airlines
Mon 6/226:02 am
DSM
-
MDT
1 stop6h 53m
American Airlines
Deal found 2/26$408

Find flight deals from Harrisburg to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$279
(Delta)

Popular in

July

Cheapest in

April

Average price

$339
Provider with most accurate pricing for Harrisburg-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Harrisburg-Des Moines flights.
Search Deals
From Harrisburg to Des Moines
Search Deals
Highest demand for flights based on searches. 30% potential increase in price ($178 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 28, 2026.
Use the filters below to find and compare flights from Harrisburg to Des Moines that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Wed 4/22

5:47 pm-9:27 pm

1 stop4h 40m

Des Moines

Tue 5/5

11:40 am-11:28 pm

2 stops10h 48m

$344

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Thu 5/28

6:53 pm-11:59 pm

1 stop6h 06m

Des Moines

Sun 5/31

6:02 am-1:55 pm

1 stop6h 53m

$374

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Tue 4/7

6:15 am-2:25 pm

2 stops9h 10m

Des Moines

Thu 4/9

7:04 pm-12:27 am

1 stop4h 23m

$412

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Fri 6/12

8:15 am-1:14 pm

1 stop5h 59m

Des Moines

Sun 6/14

1:46 pm-10:02 pm

1 stop7h 16m

$459

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Mon 6/22

5:50 pm-9:40 pm

1 stop4h 50m

Des Moines

Thu 6/25

11:23 am-11:30 pm

2 stops11h 07m

$502

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Fri 8/14

6:20 pm-8:30 am

1 stop15h 10m

Des Moines

Mon 8/17

9:00 am-11:51 pm

1 stop13h 51m

$565

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Fri 8/14

5:31 pm-10:51 pm

1 stop6h 20m

Des Moines

Mon 8/17

5:03 pm-9:24 am

2 stops15h 21m

$612

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Wed 3/11

6:15 am-4:07 pm

2 stops10h 52m

Des Moines

Sun 3/15

8:00 am-9:05 pm

1 stop12h 05m

$652

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Fri 3/13

2:33 pm-11:35 pm

2 stops10h 02m

Des Moines

Tue 3/17

2:04 pm-11:13 pm

2 stops8h 09m

$677

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Fri 3/13

2:33 pm-9:40 pm

2 stops8h 07m

Des Moines

Sun 3/15

8:00 am-9:05 pm

1 stop12h 05m

$697

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/24

Showing 1-10 of 11 resultsSorted by cheapest first
1
2

Compare providers for flights from Harrisburg to Des Moines

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Harrisburg to Des Moines in February.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Harrisburg-Des Moines flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Harrisburg-Des Moines flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Harrisburg-Des Moines flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Harrisburg-Des Moines flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Harrisburg-Des Moines flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Harrisburg to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to Des Moines

What is the cheapest month to book a flight from Harrisburg to Des Moines?

Currently, July is the cheapest month in which you can book a flight from Harrisburg to Des Moines (average of $145). Flying from Harrisburg to Des Moines in December is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Harrisburg to Des Moines?

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated February 28, 2026.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Harrisburg to Des Moines to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,245 reviews

Entertainment

7.8

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,245 reviews
Delta
7.9
Good
8,245 reviews

Entertainment

7.8

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,363 reviews
Delta
7.9
Good
8,245 reviews

Entertainment

7.8

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,367 reviews
Delta
7.9
Good
8,245 reviews

Entertainment

7.8

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Harrisburg to Des Moines?

    United Airlines and American Airlines can get you from Harrisburg to Des Moines in just under 4h 40m. Your travel time can differ by up to 1h 26m. The distance from Harrisburg to Des Moines is about 886 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Harrisburg to Des Moines round-trip?

    Cheapflights users have booked flights from Harrisburg to Des Moines round-trip from $248. Other airlines that can offer you cheap pricing are United Airlines, from $248, and Delta, from $268. You may be able to fly from Harrisburg to Des Moines for 38% less than the average price by searching for these airlines.

  • Can I find deals for flights from Harrisburg to Des Moines that include hotel bookings?

    Yes. In addition to deals on Harrisburg to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to Des Moines.

  • Can I find deals for business class flights from Harrisburg to Des Moines?

    Yes. Cheapflights offers flight deals from Harrisburg to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to Des Moines?

    Currently, July is the cheapest month in which you can book a flight from Harrisburg to Des Moines (average of $145). Flying from Harrisburg to Des Moines in December is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Ankeny
Boone
Ames
Clive
West Des Moines

Browse thousands of different options on Cheapflights for your next trip

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Top 3 airlines flying from Harrisburg to Des Moines

Discover the top 3 airlines that operate flights from Harrisburg to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$248Average$377FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$248Average$343FlexibilityNo cancel feeOn-time69%
DeltaCheapest$268Average$378FlexibilityNo cancel feeOn-timeN/A

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