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Des Moines

$168+ Cheap flights from Harrisburg to Des Moines (MDT - DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/5. Fares are subject to change and may not be available on all flights or dates of travel.
MDT — DSM
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Harrisburg to Des Moines

Discover tips and strategies to find the most affordable flight options for your journey from Harrisburg (MDT) to Des Moines (DSM). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$249
(Delta)

One-way from

$168
(Kiwi.com)

Popular in

January

Cheapest in

April

Average price

$308
From Harrisburg to Des Moines
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One-way flight from Harrisburg to Des Moines
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Highest demand for flights based on searches. 19% potential increase in price ($109 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($19 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Harrisburg to Des Moines

Cheapest flights from Harrisburg to Des Moines
Explore the most affordable flight options available from Harrisburg to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/116:00 amMDT - DSM
1 stop5h 05mDelta
Tue 10/145:56 pmDSM - MDT
1 stop4h 04mDelta
Deal found 9/15$249
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/186:15 amMDT - DSM
2 stops9h 08mUnited Airlines
Sat 10/2512:52 pmDSM - MDT
1 stop6h 07mUnited Airlines
Deal found 9/15$254
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:23 pmMDT - DSM
1 stop5h 14mDelta
Sat 10/45:12 pmDSM - MDT
1 stop5h 34mDelta
Deal found 9/15$259
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:30 amMDT - DSM
2 stops10h 47mUnited Airlines
Sat 10/412:52 pmDSM - MDT
1 stop7h 33mUnited Airlines
Deal found 9/15$264
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/264:45 pmMDT - DSM
1 stop7h 21mAmerican Airlines
Sun 10/56:00 amDSM - MDT
1 stop4h 35mAmerican Airlines
Deal found 9/14$324
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1110:25 amMDT - DSM
2 stops7h 59mUnited Airlines
Tue 10/143:25 pmDSM - MDT
1 stop5h 00mUnited Airlines
Deal found 9/15$397
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/186:00 amMDT - DSM
1 stop5h 40mDelta
Sat 9/205:12 pmDSM - MDT
1 stop5h 34mDelta
Deal found 9/15$419
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/173:30 pmMDT - DSM
1 stop5h 41mAmerican Airlines
Sun 10/196:44 amDSM - MDT
1 stop5h 23mAmerican Airlines
Deal found 9/13$422
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/238:21 pmMDT - DSM
1 stop13h 23mMultiple Airlines
Sun 10/268:47 pmDSM - MDT
2 stops19h 49mMultiple Airlines
Deal found 9/15$437
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/266:30 amMDT - DSM
1 stop5h 00mUnited Airlines
Mon 12/16:50 pmDSM - MDT
1 stop25h 19mUnited Airlines
Deal found 9/14$484

Cheapflights Fare Finder

 
Customize your flight search to find flights from Harrisburg to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Harrisburg to Des Moines that are best for you.

Fly from

Harrisburg

Fly to

Des Moines

Route

Depart

Return

Price

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Sat 10/18

6:10 am-9:19 am

1 stop4h 09m

Des Moines

Sat 10/25

5:15 pm-11:08 pm

1 stop4h 53m

$249

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Wed 10/22

6:00 am-10:05 am

1 stop5h 05m

Des Moines

Sat 10/25

5:15 pm-11:08 pm

1 stop4h 53m

$249

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Sat 10/11

6:00 am-10:05 am

1 stop5h 05m

Des Moines

Tue 10/14

5:56 pm-11:00 pm

1 stop4h 04m

$249

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Sat 10/18

6:15 am-2:23 pm

2 stops9h 08m

Des Moines

Sat 10/25

12:52 pm-7:59 pm

1 stop6h 07m

$254

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Tue 9/30

6:23 pm-10:37 pm

1 stop5h 14m

Des Moines

Sat 10/4

5:12 pm-11:46 pm

1 stop5h 34m

$259

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Tue 9/30

6:30 am-4:17 pm

2 stops10h 47m

Des Moines

Sat 10/4

12:52 pm-9:25 pm

1 stop7h 33m

$264

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Wed 10/22

6:15 am-2:23 pm

2 stops9h 08m

Des Moines

Sat 10/25

9:20 am-7:59 pm

2 stops9h 39m

$303

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Wed 2/18

7:39 am-2:26 pm

1 stop7h 47m

Des Moines

Sat 2/21

4:27 pm-9:25 pm

1 stop3h 58m

$319

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Fri 9/26

4:45 pm-11:06 pm

1 stop7h 21m

Des Moines

Sun 10/5

6:00 am-11:35 am

1 stop4h 35m

$324

HarrisburgDes Moines

MDT - DSM

MDTDSM

Harrisburg

Sun 10/5

8:21 pm-8:30 am

1 stop13h 09m

$168

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 19 results
1
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Best time to book a flight from Harrisburg to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Harrisburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Harrisburg to Des Moines

What is the cheapest month to book a flight from Harrisburg to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Harrisburg to Des Moines (average of $336). Flying from Harrisburg to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MDT to DSM?

Find hourly flight availability from Harrisburg to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

When flying from Harrisburg to Des Moines, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 15% versus a flight in the morning.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated September 15, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Harrisburg to Des Moines to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,954 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,954 reviews
Delta
8.0
Very good
7,954 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,929 reviews
Delta
8.0
Very good
7,954 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,954 reviews

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Harrisburg to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Harrisburg to Des Moines?

    Delta and United Airlines can get you from Harrisburg to Des Moines in just under 4h 09m. Your travel time can differ by up to 4h 59m. The distance from Harrisburg to Des Moines is about 886 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Harrisburg to Des Moines round-trip?

    Cheapflights users have booked flights from Harrisburg to Des Moines round-trip from $248. Other airlines that can offer you cheap pricing are United Airlines, from $248, and Delta, from $278. You may be able to fly from Harrisburg to Des Moines for 44% less than the average price by searching for these airlines.

  • Can I find deals for flights from Harrisburg to Des Moines that include hotel bookings?

    Yes. In addition to deals on Harrisburg to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Harrisburg to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Harrisburg to Des Moines.

  • Can I find deals for business class flights from Harrisburg to Des Moines?

    Yes. Cheapflights offers flight deals from Harrisburg to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Harrisburg to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Harrisburg to Des Moines (average of $336). Flying from Harrisburg to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Alternative routes for Harrisburg to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Harrisburg to Des Moines

Discover the top 3 airlines that operate flights from Harrisburg to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$248Average$417FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$248Average$376FlexibilityNo cancel feeOn-time71%
DeltaCheapest$278Average$383FlexibilityNo cancel feeOn-timeN/A

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