$202+ Cheap flights from Wyoming to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/1. Fares are subject to change and may not be available on all flights or dates of travel.
JAC — CHS
Dec 4 — Dec 111
Round-trip
1 adult, Economy
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Find cheap flights from Wyoming to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Wyoming to South Carolina
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Cheapest flights from Wyoming to South CarolinaExplore the most affordable flight options available from Wyoming to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
Explore the most affordable flight options available from Wyoming to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 4, 2026.
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/301:22 pm -
1 stop6h 41m
Fri 12/47:45 am -
1 stop6h 57m
Deal found 11/4![American Airlines logo]()
$513
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:21 pm -
1 stop7h 05m
Sat 11/147:00 am -
1 stop7h 39m
Deal found 11/2![American Airlines logo]()
$579
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:12 pm -
2 stops8h 47m
Sat 11/146:00 am -
2 stops12h 23m
Deal found 11/2![Delta logo]()
$589
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:00 am -
1 stop6h 06m
Sat 11/146:30 am -
2 stops10h 58m
Deal found 11/2![United Airlines logo]()
$652
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1212:25 pm -
1 stop6h 46m
Tue 12/156:15 am -
1 stop7h 08m
Deal found 10/30![United Airlines logo]()
$652
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/191:22 pm -
1 stop7h 15m
Mon 11/238:44 pm -
2 stops17h 58m
Deal found 11/3![American Airlines logo]()
$710
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/151:21 pm -
1 stop7h 05m
Thu 11/197:00 am -
1 stop7h 42m
Deal found 10/31![American Airlines logo]()
$749
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/267:00 am -
1 stop6h 06m
Tue 12/15:00 pm -
1 stop20h 23m
Deal found 11/1![United Airlines logo]()
$766
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/3010:37 am -
2 stops26h 40m
Fri 12/47:48 pm -
3 stops21h 37m
Deal found 11/4![United Airlines logo]()
$935
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/201:22 pm -
1 stop8h 01m
Fri 11/277:30 am -
1 stop7h 12m
Deal found 10/31![American Airlines logo]()
$989
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/231:22 pm -
1 stop8h 01m
Mon 11/305:12 pm -
2 stops21h 30m
Deal found 10/31![American Airlines logo]()
$1,041
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/231:22 pm -
2 stops8h 35m
Fri 11/277:30 am -
1 stop7h 12m
Deal found 10/31![American Airlines logo]()
$1,046
Best flights from Wyoming to South CarolinaDiscover carefully curated flight deals from Wyoming to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
Discover carefully curated flight deals from Wyoming to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 4, 2026.
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/52:37 pm -
1 stop7h 22m
Tue 2/94:02 pm -
1 stop6h 54m
Deal found 11/2![United Airlines logo]()
$541
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/191:22 pm -
1 stop7h 15m
Mon 11/238:44 pm -
2 stops17h 58m
Deal found 11/3![American Airlines logo]()
$710
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/67:00 am -
1 stop6h 00m
Mon 2/86:00 am -
1 stop9h 35m
Deal found 11/3![United Airlines logo]()
$644
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1212:25 pm -
1 stop6h 46m
Tue 12/156:15 am -
1 stop7h 08m
Deal found 10/30![United Airlines logo]()
$652
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/151:21 pm -
1 stop7h 05m
Thu 11/197:00 am -
1 stop7h 42m
Deal found 10/31![American Airlines logo]()
$749
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/1412:40 pm -
1 stop6h 23m
Thu 2/189:55 am -
2 stops10h 47m
Deal found 11/2![United Airlines logo]()
$689
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/301:22 pm -
2 stops9h 33m
Fri 12/46:47 pm -
2 stops19h 55m
Deal found 11/4![American Airlines logo]()
$763
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/212:40 pm -
1 stop6h 23m
Fri 2/56:30 am -
1 stop7h 08m
Deal found 11/1![United Airlines logo]()
$725
This United Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/54:09 pm -
2 stops16h 37m
Tue 2/911:27 am -
2 stops11h 29m
Deal found 10/31![United Airlines logo]()
$735
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/267:00 am -
1 stop6h 06m
Tue 12/17:56 pm -
2 stops17h 27m
Deal found 11/1![United Airlines logo]()
$772
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/231:22 pm -
1 stop8h 01m
Mon 11/305:12 pm -
2 stops21h 30m
Deal found 10/31![American Airlines logo]()
$1,041
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/201:22 pm -
2 stops8h 35m
Fri 11/277:30 am -
1 stop7h 12m
Deal found 10/31![American Airlines logo]()
$1,073
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/231:22 pm -
2 stops8h 35m
Fri 11/275:12 pm -
2 stops21h 30m
Deal found 10/31![American Airlines logo]()
$1,178
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/177:00 am -
2 stops10h 08m
Sat 11/2110:16 am -
2 stops12h 41m
Deal found 11/2![United Airlines logo]()
$1,118
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/194:10 pm -
3 stops16h 11m
Mon 11/2311:27 am -
3 stops11h 30m
Deal found 11/3![United Airlines logo]()
$1,191
Last-minute flights from Wyoming to South CarolinaDiscover last-minute flight deals from Wyoming to South Carolina. Data last updated November 4, 2026 and is based on user searches.
Discover last-minute flight deals from Wyoming to South Carolina. Data last updated November 4, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:21 pm -
1 stop7h 05m
Sat 11/147:00 am -
1 stop7h 39m
Deal found 11/2![American Airlines logo]()
$579
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/111:12 pm -
2 stops8h 47m
Sat 11/146:00 am -
2 stops12h 23m
Deal found 11/2![Delta logo]()
$589
This United Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:00 am -
1 stop6h 06m
Sat 11/146:30 am -
2 stops10h 58m
Deal found 11/2![United Airlines logo]()
$652
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/151:21 pm -
1 stop7h 05m
Thu 11/197:00 am -
1 stop7h 42m
Deal found 10/31![American Airlines logo]()
$749
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/191:22 pm -
1 stop7h 15m
Mon 11/238:44 pm -
2 stops17h 58m
Deal found 11/3![American Airlines logo]()
$710
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/201:22 pm -
1 stop8h 01m
Fri 11/277:30 am -
1 stop7h 12m
Deal found 10/31![American Airlines logo]()
$989
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/231:22 pm -
1 stop8h 01m
Mon 11/305:12 pm -
2 stops21h 30m
Deal found 10/31![American Airlines logo]()
$1,041
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/231:22 pm -
2 stops8h 35m
Fri 11/277:30 am -
1 stop7h 12m
Deal found 10/31![American Airlines logo]()
$1,046
This United Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/267:00 am -
1 stop6h 06m
Tue 12/15:00 pm -
1 stop20h 23m
Deal found 11/1![United Airlines logo]()
$766
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/301:22 pm -
1 stop6h 41m
Fri 12/47:45 am -
1 stop6h 57m
Deal found 11/4![American Airlines logo]()
$513
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/3010:37 am -
2 stops26h 40m
Fri 12/47:48 pm -
3 stops21h 37m
Deal found 11/4![United Airlines logo]()
$935
This United Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1212:25 pm -
1 stop6h 46m
Tue 12/156:15 am -
1 stop7h 08m
Deal found 10/30![United Airlines logo]()
$652
One-way flights from Wyoming to South CarolinaSearch for one-way flight options from Wyoming to South Carolina. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
Search for one-way flight options from Wyoming to South Carolina. Find affordable one-way fares based on user searches. Data last updated November 4, 2026.
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/11:22 pm -
1 stop6h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![American Airlines logo]()
$202
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/102:56 pm -
1 stop7h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Delta logo]()
$281
This American Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/11:22 pm -
1 stop8h 01m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![American Airlines logo]()
$302
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/11:07 pm -
2 stops8h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Delta logo]()
$307
This Delta deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/61:07 pm -
2 stops8h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![Delta logo]()
$317
This Delta deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/111:09 pm -
2 stops8h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Delta logo]()
$335
This American Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/61:35 pm -
1 stop6h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/4![American Airlines logo]()
$378
This American Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/101:45 pm -
2 stops21h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![American Airlines logo]()
$412
This Delta deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/54:25 pm -
2 stops14h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/4![Delta logo]()
$441
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/251:22 pm -
1 stop6h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/31![American Airlines logo]()
$470
This Alaska Airlines deal was found by Cheapflights users on 11/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/1112:27 pm -
3 stops28h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/2![Alaska Airlines logo]()
$480
This United Airlines deal was found by Cheapflights users on 11/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/17:00 am -
3 stops31h 53m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/3![United Airlines logo]()
$555
Find flight deals from Wyoming to South Carolina
Keep the following information in mind while searching for Wyoming to South Carolina flight deals. Data was last updated November 4, 2026.
Round-trip from | $541 (United Airlines) |
|---|---|
One-way from | $202 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Wyoming to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
Use the filters below to find and compare flights from Wyoming to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
JacksonCharleston
JAC Jackson Hole - CHS Charleston
JACCHS
Jackson Hole
Sun 1/10
2:56 pm-12:02 am
1 stop7h 06m
Charleston
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$281
JacksonCharleston
JAC Jackson Hole - CHS Charleston
JACCHS
Jackson Hole
Mon 1/11
1:35 pm-10:26 pm
1 stop6h 51m
Charleston
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$281
JacksonColumbia
JAC Jackson Hole - CAE Columbia Metropolitan
JACCAE
Jackson Hole
Tue 12/1
1:07 pm-11:51 pm
2 stops8h 44m
Columbia Metropolitan
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$307
JacksonColumbia
JAC Jackson Hole - CAE Columbia Metropolitan
JACCAE
Jackson Hole
Sun 12/6
1:22 pm-11:24 pm
1 stop8h 02m
Columbia Metropolitan
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$317
JacksonColumbia
JAC Jackson Hole - CAE Columbia Metropolitan
JACCAE
Jackson Hole
Sun 12/6
1:07 pm-11:51 pm
2 stops8h 44m
Columbia Metropolitan
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$317
JacksonCharleston
JAC Jackson Hole - CHS Charleston
JACCHS
Jackson Hole
Sun 1/10
1:45 pm-1:04 pm
2 stops21h 19m
Charleston
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$412
JacksonGreenville
JAC Jackson Hole - GSP Greenville
JACGSP
Jackson Hole
Tue 1/5
4:25 pm-9:17 am
2 stops14h 52m
Greenville
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$441
JacksonGreenville
JAC Jackson Hole - GSP Greenville
JACGSP
Jackson Hole
Wed 1/6
4:25 pm-9:17 am
2 stops14h 52m
Greenville
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$441
Quickest round-trip
JacksonGreenville
JAC Jackson Hole - GSP Greenville
JACGSP
Jackson Hole
Wed 11/25
1:22 pm-10:03 pm
1 stop6h 41m
Greenville
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$470
JacksonCharleston
JAC Jackson Hole - CHS Charleston
JACCHS
Jackson Hole
Mon 1/11
12:27 pm-7:24 pm
3 stops28h 57m
Charleston
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$480
Showing 1-10 of 36 resultsSorted by cheapest first
Best time to book a flight from Wyoming to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Wyoming with our price prediction graph.
JAC-GSP
JAC-CHS
JAC-CAE
JAC-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Wyoming to South Carolina
USWY-USSC
JAC-GSP
JAC-CHS
JAC-CAE
JAC-MYR
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated November 4, 2026.
See what other customers who have flown with American Airlines from Wyoming to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
7.9
Food
6.4
Entertainment
6.8
Overall
7.0
Boarding
7.4
Comfort
7.2
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Crew
7.9
Food
6.4
Entertainment
6.8
Overall
7.0
Boarding
7.4
Comfort
7.2
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
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Alternative routes for Wyoming to South Carolina
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Complete your trip
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Wyoming and South Carolina flights
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Top airline flying from Wyoming to South Carolina
Discover the top airline that operate flights from Wyoming to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$448 | Average$551 | FlexibilityNo cancel fee | On-time71% |