HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South Carolina

$67+ Cheap flights from San Diego (SAN) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/21. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — CHS
Nov 22 — Nov 291
Sat 11/22
Sat 11/29
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from San Diego to South Carolina with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from San Diego to South Carolina

Cheapest flights from San Diego to South Carolina
Explore the most affordable flight options available from San Diego to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 23, 2025.

This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/175:15 pmSAN - GSP
2 stops13h 30mSouthwest
Tue 1/610:05 amGSP - SAN
1 stop13h 55mSouthwest
Deal found 10/22$257
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/86:46 amSAN - SAV
1 stop7h 02mAmerican Airlines
Sat 12/131:18 pmSAV - SAN
1 stop10h 39mAmerican Airlines
Deal found 10/23$259
This JetBlue deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/158:39 pmSAN - CHS
1 stop10h 49mJetBlue
Tue 11/186:15 amCHS - SAN
1 stop9h 33mJetBlue
Deal found 10/22$275
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1112:04 pmSAN - SAV
1 stop8h 59mAmerican Airlines
Mon 12/157:27 amSAV - SAN
1 stop7h 25mAmerican Airlines
Deal found 10/22$275
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1711:38 amSAN - GSP
1 stop7h 07mAmerican Airlines
Tue 1/65:26 pmGSP - SAN
1 stop8h 00mAmerican Airlines
Deal found 10/22$287
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/510:47 amSAN - SAV
1 stop8h 43mAmerican Airlines
Tue 12/96:20 amSAV - SAN
1 stop8h 32mAmerican Airlines
Deal found 10/22$291
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/51:53 pmSAN - SAV
1 stop6h 22mUnited Airlines
Tue 12/97:00 amSAV - SAN
2 stops11h 02mUnited Airlines
Deal found 10/22$296
This JetBlue deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/69:20 pmSAN - SAV
1 stop11h 12mJetBlue
Tue 12/912:17 pmSAV - SAN
1 stop10h 04mJetBlue
Deal found 10/22$297
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/512:08 pmSAN - SAV
1 stop8h 07mUnited Airlines
Mon 12/84:49 pmSAV - SAN
1 stop8h 41mUnited Airlines
Deal found 10/23$307
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1210:30 pmSAN - CAE
1 stop8h 01mDelta
Wed 11/1910:11 amCAE - SAN
1 stop8h 20mDelta
Deal found 10/21$309
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1210:23 pmSAN - CAE
1 stop7h 11mAmerican Airlines
Wed 11/1912:03 pmCAE - SAN
2 stops9h 21mAmerican Airlines
Deal found 10/21$314
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1710:30 pmSAN - CHS
1 stop7h 56mDelta
Mon 11/242:30 pmCHS - SAN
1 stop8h 43mDelta
Deal found 10/21$317

Cheap flight deals from San Diego to South Carolina

Keep the following information in mind while searching for San Diego to South Carolina flight deals. Data was last updated October 23, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$239
(American Airlines)

One-way from

$67
(Kiwi.com)

Popular in

March

Cheapest in

June

Average price

$423
Provider with most accurate pricing for San Diego-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for San Diego-Myrtle Beach Intl flights.
Search Deals
From San Diego to South Carolina
Search Deals
One-way flight from San Diego to South Carolina
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($39 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Diego to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 23, 2025.
Use the filters below to find and compare flights from San Diego to South Carolina that are best for you.

Fly from

San Diego

Fly to

South Carolina

Route

Depart

Return

Price

San DiegoCharleston

SAN - CHS

SANCHS

San Diego

Wed 1/14

6:20 am-10:34 pm

1 stop13h 14m

Charleston

Wed 1/21

12:37 pm-10:26 pm

1 stop12h 49m

$258

San DiegoCharleston

SAN - CHS

SANCHS

San Diego

Sat 11/15

8:39 pm-10:28 am

1 stop10h 49m

Charleston

Tue 11/18

6:15 am-12:48 pm

1 stop9h 33m

$275

San DiegoSavannah

SAN - SAV

SANSAV

San Diego

Wed 12/10

11:02 am-11:15 pm

2 stops9h 13m

Savannah/Hilton Head

Sun 12/14

4:49 pm-10:30 pm

1 stop8h 41m

$296

San DiegoGreenville

SAN - GSP

SANGSP

San Diego

Tue 1/6

10:40 pm-9:27 am

1 stop7h 47m

Greenville

Sat 1/10

5:45 am-12:28 pm

1 stop9h 43m

$297

San DiegoSavannah

SAN - SAV

SANSAV

San Diego

Sat 12/6

10:30 pm-9:43 am

1 stop8h 13m

Savannah/Hilton Head

Tue 12/9

5:27 pm-11:35 pm

1 stop9h 08m

$297

San DiegoSavannah

SAN - SAV

SANSAV

San Diego

Thu 12/4

2:19 pm-11:59 pm

1 stop6h 40m

Savannah/Hilton Head

Mon 12/8

3:19 pm-8:42 pm

1 stop8h 23m

$297

San DiegoColumbia

SAN - CAE

SANCAE

San Diego

Fri 11/14

10:00 pm-9:59 am

1 stop8h 59m

Columbia Metropolitan

Mon 11/17

2:29 pm-10:20 pm

1 stop10h 51m

$309

San DiegoColumbia

SAN - CAE

SANCAE

San Diego

Wed 11/12

10:23 pm-10:39 am

1 stop9h 16m

Columbia Metropolitan

Wed 11/19

10:05 am-4:03 pm

1 stop8h 58m

$309

San DiegoColumbia

SAN - CAE

SANCAE

San Diego

Tue 12/2

2:59 pm-12:32 am

1 stop6h 33m

Columbia Metropolitan

Sat 12/6

3:38 pm-8:16 pm

1 stop7h 38m

$309

San DiegoColumbia

SAN - CAE

SANCAE

San Diego

Sat 12/6

8:00 am-6:57 pm

1 stop7h 57m

Columbia Metropolitan

Mon 12/15

6:38 am-1:02 pm

1 stop9h 24m

$309

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/23

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from San Diego to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from San Diego with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Diego to South Carolina

What is the cheapest month to book a flight from San Diego to South Carolina?

Currently, September is the cheapest month in which you can book a flight from San Diego to South Carolina (average of $154). Flying from San Diego to South Carolina in December is currently the most expensive (average of $320). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SAN to SC?

Find hourly flight availability from San Diego to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 23, 2025.

It’s optimal to fly from San Diego to South Carolina at noon. By choosing this option you can save up to 65% on the cost of your flight, compared to a flight in the afternoon.

What is the cheapest day to fly from San Diego to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from San Diego to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their San Diego to South Carolina flight should consider departing on Thursday evenings when fares are most often at their lowest. Tuesday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated October 23, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from San Diego to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,236 reviews

Overall

8.0

Crew

8.6

Comfort

8.0

Boarding

8.1

Food

7.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,236 reviews
Southwest
8.0
Very good
4,236 reviews

Overall

8.0

Crew

8.6

Comfort

8.0

Boarding

8.1

Food

7.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
7.9
Good
7,982 reviews
Southwest
8.0
Very good
4,236 reviews

Overall

8.0

Crew

8.6

Comfort

8.0

Boarding

8.1

Food

7.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
8,995 reviews
Southwest
8.0
Very good
4,236 reviews

Overall

8.0

Crew

8.6

Comfort

8.0

Boarding

8.1

Food

7.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
11,032 reviews
Southwest
8.0
Very good
4,236 reviews

Overall

8.0

Crew

8.6

Comfort

8.0

Boarding

8.1

Food

7.0

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from San Diego to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from San Diego to South Carolina?

    San Diego (SAN), located 2.6 mi from the city center, is the airport you fly out of when you book flights from San Diego to South Carolina.

  • How long is the flight from San Diego to South Carolina?

    Departing from San Diego to South Carolina will take you 9h 13m. There are 2088 mi between San Diego and South Carolina. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from San Diego to South Carolina one-way?

    $96 is the cheapest one-way deal found within the past few days, from Southwest. You may also be able to find cheap deals on Frontier and American Airlines, with prices starting from $105 and $143, respectively.

  • What are the most popular routes from San Diego to South Carolina?

    When deciding which route to take from San Diego to South Carolina consider San Diego - Charlotte Douglas, San Diego - Charleston or San Diego - Savannah/Hilton Head as they are the most popular.

  • Can I find deals for flights from San Diego to South Carolina that include hotel bookings?

    Yes. In addition to deals on San Diego to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Diego to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to South Carolina.

  • Can I find deals for business class flights from San Diego to South Carolina?

    Yes. Cheapflights offers flight deals from San Diego to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Diego to South Carolina?

    Currently, September is the cheapest month in which you can book a flight from San Diego to South Carolina (average of $154). Flying from San Diego to South Carolina in December is currently the most expensive (average of $320). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for San Diego to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
Los Angeles to John F Kennedy Intl flights
San Francisco to John F Kennedy Intl flights
Los Angeles to Seattle flights
Los Angeles to Newark flights
Los Angeles to San Francisco flights
San Francisco to Los Angeles flights
Los Angeles to Dallas/Fort Worth flights
Los Angeles to LaGuardia flights
San Francisco to Las Vegas flights
San Francisco to Newark flights
Los Angeles to Honolulu flights
San Francisco to Santa Ana flights
San Francisco to Dallas/Fort Worth flights
Los Angeles to Las Vegas flights
Los Angeles to O'Hare Intl flights
Ontario to Seattle flights
San Francisco to Honolulu flights
San Francisco to Ontario flights
San Francisco to LaGuardia flights
Los Angeles to Miami flights
Los Angeles to Fort Lauderdale flights
Santa Ana to San Francisco flights
Burbank to Las Vegas flights
San Francisco to Seattle flights
Los Angeles to Boston flights
San Francisco to O'Hare Intl flights
San Jose to Los Angeles flights
Los Angeles to Orlando flights
Ontario to San Francisco flights
Los Angeles to San Jose flights
Los Angeles to Denver flights
San Diego to John F Kennedy Intl flights
Santa Ana to Seattle flights
Los Angeles to Reagan-National flights
Ontario to Las Vegas flights
Los Angeles to Portland flights
San Jose to Las Vegas flights
Los Angeles to Sky Harbor Intl flights
Los Angeles to Hobby flights
San Francisco to Orlando flights
Los Angeles to Austin flights
Santa Ana to Las Vegas flights
San Francisco to Sky Harbor Intl flights
Los Angeles to Kahului flights
San Diego to Seattle flights
Los Angeles to Baltimore flights
Los Angeles to Dulles Intl flights
San Diego to Newark flights
Ontario to John F Kennedy Intl flights
San Jose to Seattle flights

Top 4 airlines flying from San Diego to South Carolina

Discover the top 4 airlines that operate flights from San Diego to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$233Average$489FlexibilityNo cancel feeOn-time69%
DeltaCheapest$249Average$445FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$264Average$480FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$357Average$465FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.