$80+ Cheap flights from San Diego (SAN) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/22. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — CHS
Apr 25 — May 21
Round-trip
1 adult, Economy
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Find cheap flights from San Diego to South Carolina with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from San Diego to South CarolinaExplore the most affordable flight options available from San Diego to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 26, 2026.
Explore the most affordable flight options available from San Diego to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 26, 2026.
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/121:03 pm
SAN
- GSP
1 stop6h 59m
American Airlines
Tue 5/195:12 pm
GSP
- SAN
1 stop7h 48m
American Airlines
Deal found 3/25![American Airlines logo]()
$299
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/288:45 am
SAN
- CHS
1 stop7h 48m
United Airlines
Wed 5/65:07 pm
CHS
- SAN
1 stop7h 18m
United Airlines
Deal found 3/24![United Airlines logo]()
$300
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1210:20 am
SAN
- GSP
2 stops8h 20m
Southwest
Tue 5/195:05 pm
GSP
- SAN
1 stop7h 15m
Southwest
Deal found 3/25![Southwest logo]()
$304
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/211:03 pm
SAN
- CHS
1 stop6h 33m
American Airlines
Tue 4/286:00 am
CHS
- SAN
1 stop8h 53m
American Airlines
Deal found 3/24![American Airlines logo]()
$305
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2110:23 am
SAN
- SAV
1 stop8h 36m
United Airlines
Wed 4/295:04 pm
SAV
- SAN
1 stop8h 55m
United Airlines
Deal found 3/26![United Airlines logo]()
$306
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/291:36 pm
SAN
- SAV
1 stop7h 22m
American Airlines
Wed 5/137:45 pm
SAV
- SAN
1 stop7h 11m
American Airlines
Deal found 3/24![American Airlines logo]()
$311
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:45 am
SAN
- CHS
2 stops10h 15m
Southwest
Tue 6/94:15 pm
CHS
- SAN
2 stops9h 35m
Southwest
Deal found 3/25![Southwest logo]()
$315
This Southwest deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:20 am
SAN
- CHS
1 stop11h 05m
Southwest
Tue 4/287:15 am
CHS
- SAN
2 stops10h 05m
Southwest
Deal found 3/24![Southwest logo]()
$316
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/229:45 pm
SAN
- MYR
1 stop7h 39m
American Airlines
Wed 4/294:52 pm
MYR
- SAN
1 stop8h 08m
American Airlines
Deal found 3/23![American Airlines logo]()
$318
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:20 am
SAN
- SAV
1 stop11h 05m
Southwest
Wed 4/296:40 am
SAV
- SAN
2 stops8h 30m
Southwest
Deal found 3/26![Southwest logo]()
$322
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/51:03 pm
SAN
- MYR
1 stop6h 59m
American Airlines
Sat 5/96:04 am
MYR
- SAN
1 stop8h 05m
American Airlines
Deal found 3/24![American Airlines logo]()
$331
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/119:45 pm
SAN
- CHS
1 stop9h 28m
United Airlines
Tue 5/124:01 pm
CHS
- SAN
1 stop8h 11m
United Airlines
Deal found 3/26![United Airlines logo]()
$332
Best flights from San Diego to South CarolinaDiscover carefully curated flight deals from San Diego to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 26, 2026.
Discover carefully curated flight deals from San Diego to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 26, 2026.
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:45 pm
SAN
- CHS
2 stops10h 28m
United Airlines
Tue 5/125:07 pm
CHS
- SAN
1 stop7h 18m
United Airlines
Deal found 3/26![United Airlines logo]()
$342
This Southwest deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1310:40 pm
SAN
- CHS
1 stop10h 45m
Southwest
Tue 4/287:15 am
CHS
- SAN
2 stops10h 05m
Southwest
Deal found 3/22![Southwest logo]()
$353
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/310:15 pm
SAN
- MYR
1 stop9h 22m
Delta
Tue 6/95:30 pm
MYR
- SAN
1 stop9h 05m
Delta
Deal found 3/25![Delta logo]()
$358
This JetBlue deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/511:05 am
SAN
- SAV
1 stop9h 13m
JetBlue
Wed 5/610:41 am
SAV
- SAN
1 stop12h 19m
JetBlue
Deal found 3/22![JetBlue logo]()
$390
This American Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/39:50 am
SAN
- MYR
2 stops8h 57m
American Airlines
Tue 6/94:17 pm
MYR
- SAN
1 stop8h 31m
American Airlines
Deal found 3/25![American Airlines logo]()
$391
This Alaska Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/11:36 pm
SAN
- CLT
Nonstop4h 52m
Alaska Airlines
Tue 5/55:58 pm
CLT
- SAN
Nonstop5h 11m
Alaska Airlines
Deal found 3/22![Alaska Airlines logo]()
$529
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/69:45 pm
SAN
- GSP
1 stop8h 19m
Delta
Fri 5/87:20 am
GSP
- SAN
1 stop10h 00m
Delta
Deal found 3/24![Delta logo]()
$362
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2310:40 pm
SAN
- GSP
1 stop8h 31m
United Airlines
Sat 5/304:15 pm
GSP
- SAN
1 stop7h 31m
United Airlines
Deal found 3/24![United Airlines logo]()
$363
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:20 am
SAN
- SAV
2 stops9h 05m
Southwest
Wed 4/292:20 pm
SAV
- SAN
2 stops8h 35m
Southwest
Deal found 3/26![Southwest logo]()
$374
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/81:31 pm
SAN
- AGS
1 stop7h 27m
American Airlines
Tue 5/125:08 pm
AGS
- SAN
1 stop7h 52m
American Airlines
Deal found 3/24![American Airlines logo]()
$392
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/187:35 am
SAN
- CHS
1 stop9h 40m
Southwest
Sat 4/252:45 pm
CHS
- SAN
1 stop9h 40m
Southwest
Deal found 3/25![Southwest logo]()
$379
This Delta deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/810:25 pm
SAN
- CAE
1 stop7h 50m
Delta
Fri 5/157:17 pm
CAE
- SAN
1 stop7h 10m
Delta
Deal found 3/24![Delta logo]()
$389
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2310:28 pm
SAN
- AGS
1 stop7h 01m
American Airlines
Sat 5/305:00 am
AGS
- SAN
1 stop7h 04m
American Airlines
Deal found 3/23![American Airlines logo]()
$392
This JetBlue deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/99:10 pm
SAN
- CHS
1 stop10h 18m
JetBlue
Tue 5/1211:24 am
CHS
- SAN
1 stop11h 36m
JetBlue
Deal found 3/24![JetBlue logo]()
$433
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:22 pm
SAN
- MYR
2 stops12h 56m
United Airlines
Fri 4/243:15 pm
MYR
- SAN
1 stop10h 44m
United Airlines
Deal found 3/24![United Airlines logo]()
$399
This Southwest deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/1510:20 am
SAN
- GSP
2 stops8h 55m
Southwest
Tue 5/195:05 pm
GSP
- SAN
1 stop7h 15m
Southwest
Deal found 3/25![Southwest logo]()
$388
This Delta deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/289:40 pm
SAN
- AGS
1 stop8h 38m
Delta
Sun 5/317:50 pm
AGS
- SAN
1 stop6h 37m
Delta
Deal found 3/21![Delta logo]()
$392
This United Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/29:05 pm
SAN
- MYR
1 stop8h 59m
United Airlines
Wed 6/33:08 pm
MYR
- SAN
1 stop10h 26m
United Airlines
Deal found 3/23![United Airlines logo]()
$409
This Southwest deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/36:30 am
SAN
- CHS
1 stop6h 50m
Southwest
Wed 5/66:40 am
CHS
- SAN
1 stop7h 05m
Southwest
Deal found 3/23![Southwest logo]()
$391
This Delta deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1710:30 pm
SAN
- MYR
1 stop8h 10m
Delta
Mon 4/207:03 pm
MYR
- SAN
1 stop7h 22m
Delta
Deal found 3/25![Delta logo]()
$394
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/110:40 pm
SAN
- CHS
1 stop8h 28m
United Airlines
Tue 6/3010:00 am
CHS
- SAN
1 stop8h 03m
United Airlines
Deal found 3/24![United Airlines logo]()
$423
This American Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/41:36 pm
SAN
- MYR
1 stop7h 21m
American Airlines
Sun 5/105:00 am
MYR
- SAN
1 stop9h 13m
American Airlines
Deal found 3/21![American Airlines logo]()
$467
This Southwest deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/187:15 am
SAN
- CHS
2 stops10h 45m
Southwest
Tue 4/287:15 am
CHS
- SAN
2 stops10h 05m
Southwest
Deal found 3/21![Southwest logo]()
$392
This Delta deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/1510:25 pm
SAN
- GSP
1 stop7h 39m
Delta
Mon 5/187:42 pm
GSP
- SAN
1 stop6h 45m
Delta
Deal found 3/26![Delta logo]()
$394
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1410:20 am
SAN
- GSP
2 stops8h 20m
Southwest
Thu 4/166:25 pm
GSP
- SAN
1 stop7h 30m
Southwest
Deal found 3/26![Southwest logo]()
$400
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1210:20 pm
SAN
- GSP
1 stop9h 54m
United Airlines
Wed 5/134:35 pm
GSP
- SAN
1 stop8h 41m
United Airlines
Deal found 3/24![United Airlines logo]()
$441
This American Airlines deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/106:15 am
SAN
- AGS
1 stop9h 22m
American Airlines
Sat 4/255:00 am
AGS
- SAN
2 stops10h 14m
American Airlines
Deal found 3/21![American Airlines logo]()
$522
This United Airlines deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/98:54 am
SAN
- CHS
1 stop7h 37m
United Airlines
Tue 5/125:07 pm
CHS
- SAN
1 stop7h 18m
United Airlines
Deal found 3/25![United Airlines logo]()
$442
This Delta deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/209:45 pm
SAN
- CAE
1 stop8h 29m
Delta
Mon 4/277:12 pm
CAE
- SAN
1 stop7h 13m
Delta
Deal found 3/21![Delta logo]()
$444
This Southwest deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1210:05 am
SAN
- GSP
2 stops8h 35m
Southwest
Tue 5/196:45 am
GSP
- SAN
2 stops9h 10m
Southwest
Deal found 3/22![Southwest logo]()
$427
Last-minute flights from San Diego to South CarolinaDiscover last-minute flight deals from San Diego to South Carolina. Data last updated March 26, 2026 and is based on user searches.
Discover last-minute flight deals from San Diego to South Carolina. Data last updated March 26, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1310:40 pm
SAN
- CHS
1 stop10h 45m
Southwest
Tue 4/286:40 am
CHS
- SAN
1 stop7h 05m
Southwest
Deal found 3/22![Southwest logo]()
$347
This Cheapflightsfares deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/189:15 pm
SAN
- CHS
1 stop10h 13m
JetBlue
Tue 4/2811:18 am
CHS
- SAN
1 stop11h 47m
JetBlue
Deal found 3/21![JetBlue logo]()
$334
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2012:53 pm
SAN
- CHS
1 stop8h 31m
American Airlines
Tue 4/287:00 am
CHS
- SAN
1 stop8h 13m
American Airlines
Deal found 3/24![American Airlines logo]()
$337
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/208:37 pm
SAN
- CHS
2 stops10h 46m
United Airlines
Tue 4/285:12 pm
CHS
- SAN
1 stop7h 14m
United Airlines
Deal found 3/24![United Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/211:03 pm
SAN
- CHS
1 stop6h 33m
American Airlines
Tue 4/286:00 am
CHS
- SAN
1 stop8h 53m
American Airlines
Deal found 3/24![American Airlines logo]()
$305
This United Airlines deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2110:23 am
SAN
- SAV
1 stop8h 36m
United Airlines
Wed 4/295:04 pm
SAV
- SAN
1 stop8h 55m
United Airlines
Deal found 3/26![United Airlines logo]()
$306
This Southwest deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:20 am
SAN
- CHS
1 stop11h 05m
Southwest
Tue 4/287:15 am
CHS
- SAN
2 stops10h 05m
Southwest
Deal found 3/24![Southwest logo]()
$316
This Southwest deal was found by Cheapflights users on 3/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:20 am
SAN
- SAV
1 stop11h 05m
Southwest
Wed 4/296:40 am
SAV
- SAN
2 stops8h 30m
Southwest
Deal found 3/26![Southwest logo]()
$322
This American Airlines deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/229:45 pm
SAN
- MYR
1 stop7h 39m
American Airlines
Wed 4/294:52 pm
MYR
- SAN
1 stop8h 08m
American Airlines
Deal found 3/23![American Airlines logo]()
$318
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:20 am
SAN
- SAV
2 stops9h 55m
United Airlines
Tue 4/287:00 am
SAV
- SAN
1 stop7h 04m
United Airlines
Deal found 3/24![United Airlines logo]()
$341
This United Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/288:45 am
SAN
- CHS
1 stop7h 48m
United Airlines
Wed 5/65:07 pm
CHS
- SAN
1 stop7h 18m
United Airlines
Deal found 3/24![United Airlines logo]()
$300
This American Airlines deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/291:36 pm
SAN
- SAV
1 stop7h 22m
American Airlines
Wed 5/137:45 pm
SAV
- SAN
1 stop7h 11m
American Airlines
Deal found 3/24![American Airlines logo]()
$311
One-way flights from San Diego to South CarolinaSearch for one-way flight options from San Diego to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 26, 2026.
Search for one-way flight options from San Diego to South Carolina. Find affordable one-way fares based on user searches. Data last updated March 26, 2026.
This Frontier deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/228:00 am
SAN
- CLT
1 stop7h 54m
Frontier
Deal found 3/24![Frontier logo]()
$80
This CheapOair deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1712:25 pm
SAN
- CLT
1 stop25h 31m
Frontier
Deal found 3/25![Frontier logo]()
$92
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/116:25 am
SAN
- CLT
1 stop31h 00m
Frontier
Deal found 3/25![Frontier logo]()
$93
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:25 am
SAN
- CLT
1 stop8h 13m
Frontier
Deal found 3/25![Frontier logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/147:15 am
SAN
- CLT
1 stop8h 39m
Frontier
Deal found 3/24![Frontier logo]()
$104
This Priceline deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/236:25 am
SAN
- CLT
1 stop7h 58m
Frontier
Deal found 3/24![Frontier logo]()
$105
This Trip.com deal was found by Cheapflights users on 3/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:25 am
SAN
- CLT
1 stop9h 01m
Frontier
Deal found 3/23![Frontier logo]()
$107
This Expedia deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/112:25 pm
SAN
- CLT
1 stop25h 31m
Frontier
Deal found 3/22![Frontier logo]()
$111
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:25 am
SAN
- CLT
2 stops28h 14m
Frontier
Deal found 3/25![Frontier logo]()
$113
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/166:25 am
SAN
- CLT
1 stop31h 00m
Frontier
Deal found 3/25![Frontier logo]()
$115
This Kiwi.com deal was found by Cheapflights users on 3/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/292:12 pm
SAN
- CLT
2 stops22h 12m
Frontier
Deal found 3/25![Frontier logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 3/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:25 am
SAN
- SAV
2 stops28h 30m
Multiple Airlines
Deal found 3/24![Multiple Airlines logo]()
$144
Find flight deals from San Diego to South Carolina
Keep the following information in mind while searching for San Diego to South Carolina flight deals. Data was last updated March 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $299 (American Airlines) |
One-way from | $80 (Frontier) |
Popular in | March |
Cheapest in | October |
Average price | $566 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Diego to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2026.
Use the filters below to find and compare flights from San Diego to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San DiegoCharleston
SAN - CHS
SANCHS
San Diego
Mon 5/11
8:45 pm-10:13 am
2 stops10h 28m
Charleston
Tue 5/12
5:07 pm-9:25 pm
1 stop7h 18m
$342
San DiegoCharleston
SAN - CHS
SANCHS
San Diego
Mon 4/13
10:40 pm-12:25 pm
1 stop10h 45m
Charleston
Tue 4/28
7:15 am-2:20 pm
2 stops10h 05m
$353
San DiegoMyrtle Beach
SAN - MYR
SANMYR
San Diego
Wed 6/3
10:15 pm-10:37 am
1 stop9h 22m
Myrtle Beach Intl
Tue 6/9
5:30 pm-11:35 pm
1 stop9h 05m
$358
San DiegoGreenville
SAN - GSP
SANGSP
San Diego
Wed 5/6
9:45 pm-9:04 am
1 stop8h 19m
Greenville
Fri 5/8
7:20 am-2:20 pm
1 stop10h 00m
$362
San DiegoGreenville
SAN - GSP
SANGSP
San Diego
Sat 5/23
10:40 pm-10:11 am
1 stop8h 31m
Greenville
Sat 5/30
4:15 pm-8:46 pm
1 stop7h 31m
$363
San DiegoSavannah
SAN - SAV
SANSAV
San Diego
Tue 4/21
6:20 am-6:25 pm
2 stops9h 05m
Savannah/Hilton Head
Wed 4/29
2:20 pm-7:55 pm
2 stops8h 35m
$374
San DiegoCharleston
SAN - CHS
SANCHS
San Diego
Sat 4/18
7:35 am-8:15 pm
1 stop9h 40m
Charleston
Sat 4/25
2:45 pm-9:25 pm
1 stop9h 40m
$379
San DiegoGreenville
SAN - GSP
SANGSP
San Diego
Fri 5/15
10:20 am-10:15 pm
2 stops8h 55m
Greenville
Tue 5/19
5:05 pm-9:20 pm
1 stop7h 15m
$388
San DiegoColumbia
SAN - CAE
SANCAE
San Diego
Fri 5/8
10:25 pm-9:15 am
1 stop7h 50m
Columbia Metropolitan
Fri 5/15
7:17 pm-11:27 pm
1 stop7h 10m
$389
San DiegoSavannah
SAN - SAV
SANSAV
San Diego
Tue 5/5
11:05 am-11:18 pm
1 stop9h 13m
Savannah/Hilton Head
Wed 5/6
10:41 am-8:00 pm
1 stop12h 19m
$390
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from San Diego to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from San Diego with our price prediction graph.
SAN-CLT
SAN-SAV
SAN-CHS
SAN-MYR
SAN-GSP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Diego to South Carolina
SAN-USSC
SAN-CLT
SAN-SAV
SAN-CHS
SAN-MYR
What is the cheapest month to book a flight from San Diego to South Carolina?
Currently, January is the cheapest month in which you can book a flight from San Diego to South Carolina (average of $134). Flying from San Diego to South Carolina in February is currently the most expensive (average of $319). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SAN to SC?
Find hourly flight availability from San Diego to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 26, 2026.
It’s optimal to fly from San Diego to South Carolina at noon. By choosing this option you can save up to 74% on the cost of your flight, compared to a flight in the evening.
What is the cheapest day to fly from San Diego to South Carolina?
Use this chart to determine the cheapest time to fly round-trip from San Diego to South Carolina. Price data was last updated on March 30, 2025.
Travelers seeking maximum savings on their San Diego to South Carolina flight should consider departing on Thursday evenings when fares are most often at their lowest. Tuesday evenings flights should be avoided if possible as fares are typically the most expensive at this time.
How much does it cost to fly round-trip from San Diego to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated March 26, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from San Diego to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.6
Comfort
8.0
Food
7.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Boarding
8.1
Crew
8.6
Comfort
8.0
Food
7.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Boarding
8.1
Crew
8.6
Comfort
8.0
Food
7.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Boarding
8.1
Crew
8.6
Comfort
8.0
Food
7.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Boarding
8.1
Crew
8.6
Comfort
8.0
Food
7.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Boarding
8.1
Crew
8.6
Comfort
8.0
Food
7.0
Entertainment
7.5
Overall
8.0
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Related info for your journey
Find useful and relevant information for your journey from San Diego to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for San Diego to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from San Diego to South Carolina by cabin class
Find flights from San Diego to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
San Diego and South Carolina flights
Browse other San Diego and South Carolina flight options. Last updated on March 26, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
San Diego to South Carolina flights
Consider these flights traveling from San Diego to South Carolina.
Top 5 airlines flying from San Diego to South Carolina
Discover the top 5 airlines that operate flights from San Diego to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$126 | Average$252 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$233 | Average$484 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$248 | Average$514 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$264 | Average$436 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$363 | Average$503 | FlexibilityNo cancel fee | On-time63% |