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South Carolina

$81+ Cheap flights from San Diego (SAN) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/24. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — CHS
Jan 25 — Feb 11
Sun 1/25
Sun 2/1
1 adult, Economy
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Cheap flight deals from San Diego to South Carolina

Cheapest flights from San Diego to South Carolina
Explore the most affordable flight options available from San Diego to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 26, 2025.

This Delta deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/318:00 amSAN - CLT
1 stop8h 10mDelta
Thu 1/17:05 amCLT - SAN
1 stop7h 58mDelta
Deal found 12/25$373
This eDestinos deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/3010:10 pmSAN - CLT
2 stops31h 19mMultiple Airlines
Tue 1/68:46 pmCLT - SAN
2 stops41h 06mMultiple Airlines
Deal found 12/24$394
This Delta deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/252:15 pmSAN - CLT
1 stop6h 31mDelta
Wed 12/316:12 pmCLT - SAN
1 stop8h 01mDelta
Deal found 12/25$408
This Delta deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2411:25 amSAN - GSP
1 stop8h 05mDelta
Thu 1/16:15 amGSP - SAN
1 stop7h 00mDelta
Deal found 12/24$410
This American Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:15 amSAN - CLT
Nonstop4h 45mAmerican Airlines
Fri 1/24:43 pmCLT - SAN
Nonstop5h 13mAmerican Airlines
Deal found 12/24$413
This American Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3110:01 pmSAN - CAE
1 stop7h 38mAmerican Airlines
Sat 1/37:46 pmCAE - SAN
1 stop7h 13mAmerican Airlines
Deal found 12/24$421
This Delta deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/252:15 pmSAN - CLT
1 stop6h 31mDelta
Thu 1/18:15 amCLT - SAN
1 stop10h 11mDelta
Deal found 12/25$423
This eDestinos deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/3010:10 pmSAN - CLT
2 stops31h 19mMultiple Airlines
Mon 1/126:00 pmCLT - SAN
2 stops32h 07mMultiple Airlines
Deal found 12/25$424
This CheapOair deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/264:47 pmSAN - CLT
1 stop22h 50mFrontier
Thu 1/112:17 pmCLT - SAN
1 stop14h 42mFrontier
Deal found 12/25$428
This Priceline deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:25 amSAN - CLT
1 stop7h 17mFrontier
Sat 1/37:32 pmCLT - SAN
1 stop7h 27mFrontier
Deal found 12/25$432
This Priceline deal was found by Cheapflights users on 12/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/286:25 amSAN - CHS
1 stop9h 40mFrontier
Thu 1/13:06 pmCHS - SAN
1 stop9h 59mFrontier
Deal found 12/25$512
This United Airlines deal was found by Cheapflights users on 12/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/248:00 amSAN - GSP
2 stops12h 56mUnited Airlines
Thu 1/19:40 amGSP - SAN
1 stop9h 15mUnited Airlines
Deal found 12/24$535

Find flight deals from San Diego to South Carolina

Keep the following information in mind while searching for San Diego to South Carolina flight deals. Data was last updated December 26, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$269
(JetBlue)

One-way from

$81
(CheapOair)

Popular in

December

Cheapest in

October

Average price

$542
Provider with most accurate pricing for San Diego-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for San Diego-Myrtle Beach Intl flights.
Search Deals
From San Diego to South Carolina
Search Deals
One-way flight from San Diego to South Carolina
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($35 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($8 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Diego to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 26, 2025.
Use the filters below to find and compare flights from San Diego to South Carolina that are best for you.

Fly from

San Diego

Fly to

South Carolina

Route

Depart

Return

Price

San DiegoCharleston

SAN - CHS

SANCHS

San Diego

Thu 1/22

9:00 pm-9:20 am

1 stop9h 20m

Charleston

Thu 1/29

10:10 am-7:50 pm

1 stop12h 40m

$269

San DiegoCharleston

SAN - CHS

SANCHS

San Diego

Thu 1/15

9:00 pm-9:19 am

1 stop9h 19m

Charleston

Sun 1/18

10:10 am-7:50 pm

1 stop12h 40m

$269

San DiegoCharleston

SAN - CHS

SANCHS

San Diego

Sat 1/17

9:00 pm-9:20 am

1 stop9h 20m

Charleston

Wed 1/21

12:09 pm-8:20 pm

1 stop11h 11m

$269

San DiegoCharleston

SAN - CHS

SANCHS

San Diego

Wed 1/28

9:00 pm-9:20 am

1 stop9h 20m

Charleston

Sat 1/31

12:09 pm-8:20 pm

1 stop11h 11m

$307

San DiegoSavannah

SAN - SAV

SANSAV

San Diego

Fri 1/16

3:30 pm-7:28 pm

1 stop24h 58m

Savannah/Hilton Head

Wed 1/21

1:10 pm-8:20 pm

1 stop10h 10m

$314

San DiegoColumbia

SAN - CAE

SANCAE

San Diego

Sat 2/14

1:37 pm-11:59 pm

1 stop7h 22m

Columbia Metropolitan

Sun 2/15

7:44 pm-11:59 pm

1 stop7h 15m

$319

San DiegoSavannah

SAN - SAV

SANSAV

San Diego

Sat 1/24

9:30 pm-12:09 pm

1 stop11h 39m

Savannah/Hilton Head

Sat 1/31

1:10 pm-8:20 pm

1 stop10h 10m

$320

San DiegoCharleston

SAN - CHS

SANCHS

San Diego

Mon 2/2

9:40 pm-11:48 am

1 stop11h 08m

Charleston

Fri 2/6

10:10 am-7:49 pm

1 stop12h 39m

$321

San DiegoColumbia

SAN - CAE

SANCAE

San Diego

Thu 1/22

10:52 am-9:21 pm

1 stop7h 29m

Columbia Metropolitan

Sun 1/25

5:07 pm-10:33 pm

1 stop8h 26m

$329

San DiegoColumbia

SAN - CAE

SANCAE

San Diego

Fri 1/23

10:45 pm-9:42 am

1 stop7h 57m

Columbia Metropolitan

Fri 2/6

10:10 am-4:54 pm

1 stop9h 44m

$329

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/24

Showing 1-10 of 60 results
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Best time to book a flight from San Diego to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from San Diego with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Diego to South Carolina

What is the cheapest month to book a flight from San Diego to South Carolina?

Currently, September is the cheapest month in which you can book a flight from San Diego to South Carolina (average of $154). Flying from San Diego to South Carolina in December is currently the most expensive (average of $306). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SAN to SC?

Find hourly flight availability from San Diego to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 26, 2025.

It’s optimal to fly from San Diego to South Carolina at noon. By choosing this option you can save up to 66% on the cost of your flight, compared to a flight in the afternoon.

What is the cheapest day to fly from San Diego to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from San Diego to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their San Diego to South Carolina flight should consider departing on Thursday evenings when fares are most often at their lowest. Tuesday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated December 26, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from San Diego to South Carolina have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,258 reviews

Comfort

8.0

Food

7.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
10.0
Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.
Southwest
8.0
Very good
4,258 reviews
Southwest
8.0
Very good
4,258 reviews

Comfort

8.0

Food

7.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
10.0
Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.
Delta
7.9
Good
8,013 reviews
Southwest
8.0
Very good
4,258 reviews

Comfort

8.0

Food

7.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
10.0
Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.
United Airlines
7.4
Good
9,115 reviews
Southwest
8.0
Very good
4,258 reviews

Comfort

8.0

Food

7.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
10.0
Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.
American Airlines
7.2
Good
11,064 reviews
Southwest
8.0
Very good
4,258 reviews

Comfort

8.0

Food

7.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
10.0
Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.
JetBlue
7.2
Good
2,900 reviews
Southwest
8.0
Very good
4,258 reviews

Comfort

8.0

Food

7.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
10.0
Excellent

William Drew,Nov 2025

SJC - HNL

Flight crew was amazing! Usually they're very good on Southwest, but this crew went above and beyond. I have never ever seen so many rounds of drink service on a flight before.

Related info for your journey

Find useful and relevant information for your journey from San Diego to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from San Diego to South Carolina?

    San Diego (SAN), located 2.6 mi from the city center, is the airport you fly out of when you book flights from San Diego to South Carolina.

  • How long is the flight from San Diego to South Carolina?

    Departing from San Diego to South Carolina will take you 7h 22m. There are 2072 mi between San Diego and South Carolina. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from San Diego to South Carolina one-way?

    $107 is the cheapest one-way deal found within the past few days, from Southwest. You may also be able to find cheap deals on American Airlines and United Airlines, with prices starting from $108 and $143, respectively.

  • What are the most popular routes from San Diego to South Carolina?

    When deciding which route to take from San Diego to South Carolina consider San Diego - Charlotte Douglas, San Diego - Charleston or San Diego - Myrtle Beach Intl as they are the most popular.

  • Can I find deals for flights from San Diego to South Carolina that include hotel bookings?

    Yes. In addition to deals on San Diego to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Diego to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to South Carolina.

  • Can I find deals for business class flights from San Diego to South Carolina?

    Yes. Cheapflights offers flight deals from San Diego to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Diego to South Carolina?

    Currently, September is the cheapest month in which you can book a flight from San Diego to South Carolina (average of $154). Flying from San Diego to South Carolina in December is currently the most expensive (average of $306). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for San Diego to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from San Diego to South Carolina

Discover the top 5 airlines that operate flights from San Diego to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$126Average$268FlexibilityNo cancel feeOn-time62%
United AirlinesCheapest$233Average$493FlexibilityNo cancel feeOn-time69%
DeltaCheapest$249Average$432FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$257Average$488FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$344Average$474FlexibilityNo cancel feeOn-time63%

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