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South America

$136+ Cheap flights from St. Louis (STL) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BOG
oct. 11 — oct. 181
sáb. 10/11
sáb. 10/18
1 adult, Economy
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Cheap flight deals from St. Louis to South America

Keep the following information in mind while searching for St. Louis to South America flight deals. Data was last updated septiembre 11, 2025.

Round-trip from

$303
(Expedia)

One-way from

$136
(CheapOair)

Popular in

June

Cheapest in

April

Average price

$1,108
From Lambert-St Louis to South America
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One-way flight from Lambert-St Louis to South America
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Highest demand for flights based on searches. 3% potential increase in price ($37 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($29 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from St. Louis to South America

Cheapest flights from St. Louis to South America
Explore the most affordable flight options available from St. Louis to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 11, 2025.

This Expedia deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/2610:57 amSTL - MDE
1 stop13h 24mSpirit Airlines
sáb. 11/12:16 amMDE - STL
1 stop8h 46mSpirit Airlines
Deal found 9/11$303
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/257:15 pmSTL - CTG
1 stop17h 10mSpirit Airlines
sáb. 11/11:32 pmCTG - STL
1 stop21h 30mSpirit Airlines
Deal found 9/10$319
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/154:00 pmSTL - MDE
2 stops21h 14mMultiple Airlines
vie. 10/172:22 pmMDE - STL
1 stop27h 48mMultiple Airlines
Deal found 9/11$372
This Mytrip deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 10/257:15 pmSTL - CTG
1 stop17h 10mMultiple Airlines
sáb. 11/19:56 pmCTG - STL
2 stops13h 06mMultiple Airlines
Deal found 9/10$373
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/154:00 pmSTL - MDE
2 stops21h 14mMultiple Airlines
vie. 10/101:16 amMDE - STL
1 stop16h 54mMultiple Airlines
Deal found 9/11$393
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/2611:32 amSTL - MDE
2 stops12h 49mMultiple Airlines
sáb. 11/12:16 amMDE - STL
1 stop8h 46mMultiple Airlines
Deal found 9/11$395
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 9/1410:35 amSTL - MDE
1 stop13h 53mSpirit Airlines
vie. 10/172:22 pmMDE - STL
1 stop27h 48mSpirit Airlines
Deal found 9/10$397
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 9/1410:35 amSTL - MDE
1 stop13h 53mSpirit Airlines
vie. 10/101:16 amMDE - STL
1 stop16h 54mSpirit Airlines
Deal found 9/10$419
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 9/1410:35 amSTL - MDE
1 stop13h 53mSpirit Airlines
mié. 10/151:16 amMDE - STL
1 stop8h 46mSpirit Airlines
Deal found 9/11$426
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/2310:57 amSTL - MDE
1 stop13h 24mMultiple Airlines
lun. 10/271:59 pmMDE - STL
2 stops19h 08mMultiple Airlines
Deal found 9/10$439
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/412:20 pmSTL - CTG
1 stop23h 48mMultiple Airlines
lun. 12/82:16 pmCTG - STL
2 stops33h 30mMultiple Airlines
Deal found 9/10$471
This Kiwi.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/212:20 pmSTL - CTG
1 stop23h 48mMultiple Airlines
lun. 12/82:16 pmCTG - STL
2 stops33h 30mMultiple Airlines
Deal found 9/10$516

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
Use the filters below to find and compare flights from St. Louis to South America that are best for you.

Fly from

St. Louis

Fly to

South America

Route

Depart

Return

Price

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

sáb. 10/25

7:15 pm-12:25 pm

1 stop17h 10m

Cartagena Rafael Nunez

sáb. 11/1

1:32 pm-11:02 am

1 stop21h 30m

$319

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

sáb. 10/25

7:15 pm-12:25 pm

1 stop17h 10m

Cartagena Rafael Nunez

sáb. 11/1

9:56 pm-11:02 am

2 stops13h 06m

$373

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

jue. 12/4

12:20 pm-1:08 pm

1 stop23h 48m

Cartagena Rafael Nunez

lun. 12/8

2:16 pm-10:46 pm

2 stops33h 30m

$471

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

mar. 12/2

12:20 pm-1:08 pm

1 stop23h 48m

Cartagena Rafael Nunez

lun. 12/8

2:16 pm-10:46 pm

2 stops33h 30m

$516

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

mar. 12/2

5:15 am-1:26 pm

1 stop7h 11m

Cartagena Rafael Nunez

lun. 12/8

8:00 am-11:59 pm

1 stop16h 59m

$554

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

vie. 10/31

8:20 am-9:05 pm

1 stop12h 45m

Medellín Jose Maria Cordova Intl

mar. 11/11

10:45 am-6:47 pm

1 stop9h 02m

$576

St. LouisLima

STL - LIM

STLLIM

Lambert-St Louis

dom. 11/23

12:20 pm-10:58 pm

1 stop9h 38m

Lima J Chavez Intl

vie. 12/5

11:59 pm-1:53 pm

1 stop14h 54m

$594

St. LouisSao Paulo

STL - VCP

STLVCP

Lambert-St Louis

sáb. 10/25

7:15 pm-5:45 pm

1 stop20h 30m

Sao Paulo Viracopos

sáb. 11/1

10:50 pm-11:02 am

1 stop14h 12m

$609

St. LouisQuito

STL - UIO

STLUIO

Lambert-St Louis

jue. 10/23

7:05 am-6:59 pm

1 stop11h 54m

Quito Mariscal Sucr

mié. 10/29

12:55 am-2:43 pm

1 stop13h 48m

$614

St. LouisLima

STL - LIM

STLLIM

Lambert-St Louis

mar. 12/2

12:20 pm-10:58 pm

1 stop9h 38m

Lima J Chavez Intl

vie. 12/12

11:59 pm-1:53 pm

1 stop14h 54m

$618

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/10

Showing 1-10 of 60 results
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Best time to book a flight from St. Louis to South America

Have a flexible travel schedule? Discover the best time to fly to South America from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to South America

What is the cheapest month to book a flight from St. Louis to South America?

Currently, May is the cheapest month in which you can book a flight from St. Louis to South America (average of $359). Flying from St. Louis to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to SA?

Find hourly flight availability from St. Louis to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated septiembre 11, 2025.

When flying from St. Louis to South America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated septiembre 11, 2025.
Peruse reviews from past customers who have flown with Delta, LATAM Airlines, and United Airlines from St. Louis to South America to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,847 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,937 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Spirit Airlines
6.3
Okay
8,023 reviews
Delta
8.0
Very good
7,960 reviews

Entertainment

7.9

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from St. Louis to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from St. Louis to South America?

    Located just 12.7 mi from the city center, Lambert-St Louis (STL) is the airport most travelers will use when flying to South America from St. Louis.

  • How long is the flight from St. Louis to South America?

    A quick flight from St. Louis to South America can take about 11h 54m. Spirit Airlines provides one of the quickest options available for as low as $614. Airlines will cover a distance of 2790 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from St. Louis to South America one-way?

    $136 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on Avianca and American Airlines, with prices starting from $316 and $318, respectively.

  • What are the most popular routes from St. Louis to South America?

    The most popular flight routes from St. Louis to South America are Lambert-St Louis - Medellín Jose Maria Cordova Intl, Lambert-St Louis - Buenos Aires Ministro Pistarini and Lambert-St Louis - Santiago Arturo Merino Benitez.

  • Can I find deals for flights from St. Louis to South America that include hotel bookings?

    Yes. In addition to deals on St. Louis to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to South America.

  • Can I find deals for business class flights from St. Louis to South America?

    Yes. Cheapflights offers flight deals from St. Louis to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to South America?

    Currently, May is the cheapest month in which you can book a flight from St. Louis to South America (average of $359). Flying from St. Louis to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for St. Louis to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from St. Louis to South America

Discover the top 6 airlines that operate flights from St. Louis to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$307Average$427FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$474Average$917FlexibilityNo cancel feeOn-time71%
DeltaCheapest$484Average$974FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$535Average$868FlexibilityNo cancel feeOn-time81%
United AirlinesCheapest$554Average$1,049FlexibilityNo cancel feeOn-time69%
Air CanadaCheapest$758Average$767FlexibilityNo cancel feeOn-time67%

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