How long is the flight from St. Louis to South America?

A quick flight from St. Louis to South America can take about 9h 15m. Spirit Airlines provides one of the quickest options available for as low as $573. Airlines will cover a distance of 2159 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

What are the most popular routes from St. Louis to South America?

The most popular flight routes from St. Louis to South America are Lambert-St Louis - Lima J Chavez Intl, Lambert-St Louis - Medellín Jose Maria Cordova Intl and Lambert-St Louis - Buenos Aires Ministro Pistarini.

What are the most popular airlines that fly from St. Louis to South America?

Consider Delta, LATAM Airlines or American Airlines when booking your flight. These represent the most popular airlines when flying from St. Louis to South America.

What airport do you fly from for flights from St. Louis to South America?

Located just 12.7 mi from the city center, Lambert-St Louis (STL) is the airport most travelers will use when flying to South America from St. Louis.

Can I find deals for flights from St. Louis to South America that include hotel bookings?

Yes. In addition to deals on St. Louis to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from St. Louis to South America?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to South America.

Can I find deals for business class flights from St. Louis to South America?

Yes. Cheapflights offers flight deals from St. Louis to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$146+ Flights from St. Louis to South America

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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

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Cheap flight deals from St. Louis to South America

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$289 (KAYAK)
One-way from	$146 (Kiwi.com)
Popular in	January
Cheapest in	April
Average price	$1,118

Provider with most accurate pricing for Lambert-St Louis-Sao Paulo (SAO) flight deals.

Search Deals

Provider most trusted by Cheapflights users for Lambert-St Louis-Sao Paulo (SAO) flights.

Search Deals

From Lambert-St Louis to South America

Search Deals

One-way flight from Lambert-St Louis to South America

Search Deals

Highest demand for flights based on searches. 10% potential increase in price ($122 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($31 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in October 2025

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Find flight deals from St. Louis to South America

Cheapest flights from St. Louis to South America
Explore the most affordable flight options available from St. Louis to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

Thu 11/67:02 pmSTL - MDE

1 stop18h 01mSpirit Airlines

Sat 11/81:52 amMDE - STL

1 stop16h 24mSpirit Airlines

Deal found 10/26

$377

Sat 11/229:52 amSTL - BOG

1 stop27h 18mMultiple Airlines

Fri 12/53:05 pmBOG - STL

2 stops43h 42mMultiple Airlines

Deal found 10/26

$384

Sat 11/229:52 amSTL - BOG

1 stop27h 18mSpirit Airlines

Sat 12/63:05 pmBOG - STL

1 stop23h 47mSpirit Airlines

Deal found 10/26

$386

Fri 11/144:56 pmSTL - BOG

2 stops44h 14mMultiple Airlines

Sat 12/63:05 pmBOG - STL

1 stop23h 47mMultiple Airlines

Deal found 10/27

$390

Thu 11/137:02 pmSTL - BOG

1 stop18h 08mMultiple Airlines

Sat 11/151:55 pmBOG - STL

2 stops20h 12mMultiple Airlines

Deal found 10/26

$402

Thu 11/2010:53 amSTL - BOG

1 stop26h 17mSpirit Airlines

Sat 12/63:05 pmBOG - STL

1 stop23h 47mSpirit Airlines

Deal found 10/26

$403

Thu 11/209:54 pmSTL - BOG

2 stops38h 06mMultiple Airlines

Thu 12/41:47 pmBOG - STL

1 stop9h 46mMultiple Airlines

Deal found 10/28

$409

Wed 11/197:24 pmSTL - BOG

1 stop16h 36mMultiple Airlines

Fri 12/51:47 pmBOG - STL

1 stop9h 46mMultiple Airlines

Deal found 10/26

$417

Wed 11/197:24 pmSTL - BOG

1 stop16h 36mMultiple Airlines

Thu 12/41:47 pmBOG - STL

1 stop9h 46mMultiple Airlines

Deal found 10/28

$421

Mon 12/87:43 pmSTL - BOG

2 stops16h 09mMultiple Airlines

Thu 12/181:47 pmBOG - STL

1 stop9h 46mMultiple Airlines

Deal found 10/27

$423

Thu 11/137:02 pmSTL - CTG

1 stop17h 13mMultiple Airlines

Sat 11/152:20 pmCTG - STL

2 stops20h 52mMultiple Airlines

Deal found 10/27

$425

Thu 11/2010:53 amSTL - BOG

1 stop26h 17mSpirit Airlines

Wed 12/33:17 pmBOG - STL

1 stop23h 35mSpirit Airlines

Deal found 10/28

$425

Best flights from St. Louis to South America
Discover carefully curated flight deals from St. Louis to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 28, 2025.

Mon 1/128:45 amSTL - MDE

1 stop25h 18mMultiple Airlines

Fri 1/2312:09 pmMDE - STL

1 stop11h 24mMultiple Airlines

Deal found 10/27

$335

Sun 12/2811:51 amSTL - MDE

1 stop12h 37mSpirit Airlines

Wed 1/281:51 amMDE - STL

1 stop10h 10mSpirit Airlines

Deal found 10/26

$447

Tue 12/25:15 amSTL - CTG

1 stop9h 15mAmerican Airlines

Mon 12/82:30 pmCTG - STL

1 stop10h 29mAmerican Airlines

Deal found 10/27

$573

Fri 11/148:20 amSTL - BOG

1 stop13h 15mUnited Airlines

Thu 11/271:30 amBOG - STL

1 stop15h 20mUnited Airlines

Deal found 10/26

$583

Fri 11/149:33 amSTL - BOG

1 stop8h 57mDelta

Sun 11/163:55 pmBOG - STL

1 stop8h 49mDelta

Deal found 10/26

$583

Mon 3/96:00 amSTL - CTG

1 stop7h 15mLATAM Airlines

Thu 3/122:30 pmCTG - STL

1 stop9h 10mLATAM Airlines

Deal found 10/25

$597

Sat 1/105:11 pmSTL - MDE

1 stop19h 44mMultiple Airlines

Wed 1/212:54 pmMDE - STL

1 stop8h 39mMultiple Airlines

Deal found 10/27

$368

Mon 3/211:30 amSTL - VCP

2 stops20h 15mGOL

Wed 3/45:55 pmVCP - STL

2 stops43h 34mGOL

Deal found 10/25

$804

Sat 1/102:48 pmSTL - MDE

1 stop9h 08mSpirit Airlines

Wed 1/2112:09 pmMDE - STL

3 stops23h 52mSpirit Airlines

Deal found 10/27

$475

Sun 1/1112:20 pmSTL - MDE

1 stop24h 56mMultiple Airlines

Fri 1/166:35 amMDE - STL

1 stop17h 02mMultiple Airlines

Deal found 10/28

$438

Sun 1/1112:20 pmSTL - MDE

1 stop8h 20mMultiple Airlines

Tue 1/201:51 amMDE - STL

2 stops21h 42mMultiple Airlines

Deal found 10/27

$452

Sun 11/2311:08 amSTL - MDE

1 stop25h 55mSpirit Airlines

Fri 11/283:14 pmMDE - STL

1 stop18h 43mSpirit Airlines

Deal found 10/26

$500

Sat 2/144:05 pmSTL - GRU

2 stops37h 55mAir Canada

Sat 2/219:30 pmGRU - STL

1 stop20h 59mAir Canada

Deal found 10/26

$1,109

Sun 11/166:15 amSTL - BOG

1 stop15h 20mUnited Airlines

Fri 11/288:15 amBOG - STL

1 stop15h 12mUnited Airlines

Deal found 10/26

$583

Fri 11/142:42 pmSTL - BOG

2 stops21h 18mMultiple Airlines

Tue 12/21:55 pmBOG - STL

1 stop9h 38mMultiple Airlines

Deal found 10/26

$462

Sun 12/76:39 amSTL - UIO

2 stops21h 38mDelta

Thu 1/227:00 pmUIO - STL

2 stops17h 06mDelta

Deal found 10/26

$619

Sat 11/1511:20 amSTL - BOG

1 stop10h 15mUnited Airlines

Thu 11/271:30 amBOG - STL

1 stop15h 20mUnited Airlines

Deal found 10/26

$583

Fri 11/144:56 pmSTL - MDE

2 stops15h 04mMultiple Airlines

Wed 11/191:00 pmMDE - STL

1 stop21h 58mMultiple Airlines

Deal found 10/28

$470

Thu 1/153:45 pmSTL - LIM

1 stop12h 15mDelta

Thu 1/2211:40 pmLIM - STL

1 stop19h 10mDelta

Deal found 10/26

$644

Tue 11/1811:20 amSTL - BOG

1 stop16h 50mUnited Airlines

Fri 12/58:15 amBOG - STL

1 stop14h 43mUnited Airlines

Deal found 10/26

$586

Thu 11/276:00 amSTL - SCL

2 stops21h 35mLATAM Airlines

Mon 12/810:35 amSCL - STL

2 stops16h 07mLATAM Airlines

Deal found 10/26

$753

Fri 12/510:42 amSTL - MDE

2 stops37h 27mMultiple Airlines

Mon 1/1212:09 pmMDE - STL

1 stop11h 24mMultiple Airlines

Deal found 10/26

$473

Mon 2/99:59 amSTL - LIM

1 stop18h 01mDelta

Mon 2/1611:40 pmLIM - STL

1 stop10h 24mDelta

Deal found 10/28

$644

Sat 11/154:48 pmSTL - BOG

1 stop11h 22mUnited Airlines

Thu 12/48:15 amBOG - STL

1 stop14h 43mUnited Airlines

Deal found 10/26

$586

Thu 12/116:00 amSTL - SCL

1 stop22h 40mLATAM Airlines

Mon 12/156:30 pmSCL - STL

2 stops19h 15mLATAM Airlines

Deal found 10/26

$764

Wed 4/16:00 amSTL - LIM

2 stops14h 15mDelta

Wed 9/98:50 amLIM - STL

2 stops14h 47mDelta

Deal found 10/26

$644

Tue 11/1811:20 amSTL - BOG

1 stop10h 15mUnited Airlines

Thu 11/271:30 amBOG - STL

1 stop15h 20mUnited Airlines

Deal found 10/26

$586

Wed 1/286:02 pmSTL - VCP

2 stops37h 58mGOL

Sun 2/15:55 pmVCP - STL

2 stops42h 13mGOL

Deal found 10/28

$891

Sun 11/166:21 pmSTL - BOG

2 stops39h 29mMultiple Airlines

Wed 12/33:17 pmBOG - STL

1 stop23h 35mMultiple Airlines

Deal found 10/27

$512

Wed 1/149:59 amSTL - LIM

1 stop18h 01mDelta

Thu 1/228:50 amLIM - STL

2 stops15h 49mDelta

Deal found 10/26

$644

Last-minute flights from St. Louis to South America
Discover last-minute flight deals from St. Louis to South America. Data last updated October 28, 2025 and is based on user searches.

Thu 11/67:02 pmSTL - MDE

1 stop18h 01mSpirit Airlines

Sat 11/81:52 amMDE - STL

1 stop16h 24mSpirit Airlines

Deal found 10/26

$377

Thu 11/137:02 pmSTL - BOG

1 stop18h 08mMultiple Airlines

Sat 11/151:55 pmBOG - STL

2 stops20h 12mMultiple Airlines

Deal found 10/26

$402

Thu 11/137:02 pmSTL - CTG

1 stop17h 13mMultiple Airlines

Sat 11/152:20 pmCTG - STL

2 stops20h 52mMultiple Airlines

Deal found 10/27

$425

Fri 11/144:56 pmSTL - BOG

2 stops44h 14mMultiple Airlines

Sat 12/63:05 pmBOG - STL

1 stop23h 47mMultiple Airlines

Deal found 10/27

$390

Wed 11/197:24 pmSTL - BOG

1 stop16h 36mMultiple Airlines

Fri 12/51:47 pmBOG - STL

1 stop9h 46mMultiple Airlines

Deal found 10/26

$417

Wed 11/197:24 pmSTL - BOG

1 stop16h 36mMultiple Airlines

Thu 12/41:47 pmBOG - STL

1 stop9h 46mMultiple Airlines

Deal found 10/28

$421

Thu 11/2010:53 amSTL - BOG

1 stop26h 17mSpirit Airlines

Sat 12/63:05 pmBOG - STL

1 stop23h 47mSpirit Airlines

Deal found 10/26

$403

Thu 11/209:54 pmSTL - BOG

2 stops38h 06mMultiple Airlines

Thu 12/41:47 pmBOG - STL

1 stop9h 46mMultiple Airlines

Deal found 10/28

$409

Thu 11/2010:53 amSTL - BOG

1 stop26h 17mSpirit Airlines

Wed 12/33:17 pmBOG - STL

1 stop23h 35mSpirit Airlines

Deal found 10/26

$425

Sat 11/229:52 amSTL - BOG

1 stop27h 18mMultiple Airlines

Fri 12/53:05 pmBOG - STL

2 stops43h 42mMultiple Airlines

Deal found 10/26

$384

Sat 11/229:52 amSTL - BOG

1 stop27h 18mSpirit Airlines

Sat 12/63:05 pmBOG - STL

1 stop23h 47mSpirit Airlines

Deal found 10/26

$386

Sat 11/229:52 amSTL - BOG

1 stop27h 18mMultiple Airlines

Wed 12/35:00 amBOG - STL

2 stops33h 52mMultiple Airlines

Deal found 10/26

$427

One-way flights from St. Louis to South America
Search for one-way flight options from St. Louis to South America. Find affordable one-way fares based on user searches. Data last updated October 28, 2025.

Sat 1/312:48 pmSTL - BOG

2 stops15h 37mMultiple Airlines

Deal found 10/26

$146

Thu 12/42:47 pmSTL - BOG

2 stops21h 05mSpirit Airlines

Deal found 10/26

$156

Thu 11/2710:53 amSTL - BOG

1 stop26h 17mSpirit Airlines

Deal found 10/26

$159

Wed 12/37:43 pmSTL - BOG

2 stops16h 09mMultiple Airlines

Deal found 10/26

$169

Mon 2/25:11 pmSTL - BOG

1 stop18h 51mMultiple Airlines

Deal found 10/26

$170

Sun 11/2311:08 amSTL - BOG

1 stop26h 02mSpirit Airlines

Deal found 10/26

$178

Mon 12/14:13 pmSTL - BOG

1 stop19h 47mMultiple Airlines

Deal found 10/26

$185

Thu 2/512:20 pmSTL - BOG

2 stops45h 13mMultiple Airlines

Deal found 10/26

$186

Thu 1/2212:20 pmSTL - LIM

1 stop9h 38mSpirit Airlines

Deal found 10/28

$226

Sun 11/2310:24 amSTL - GRU

2 stops23h 51mMultiple Airlines

Deal found 10/26

$314

Thu 1/228:30 amSTL - LIM

2 stops18h 00mAvianca

Deal found 10/28

$361

Thu 12/1112:04 pmSTL - AEP

3 stops40h 26mMultiple Airlines

Deal found 10/27

$375

Cheapflights Fare Finder

Use the filters below to find and compare flights from St. Louis to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Mon 1/12

8:45 am-11:03 am

1 stop25h 18m

Medellín Jose Maria Cordova Intl

Fri 1/23

12:09 pm-10:33 pm

1 stop11h 24m

$335

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Sat 1/10

5:11 pm-1:55 pm

1 stop19h 44m

Medellín Jose Maria Cordova Intl

Wed 1/21

2:54 pm-10:33 pm

1 stop8h 39m

$368

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Sun 1/11

12:20 pm-2:16 pm

1 stop24h 56m

Medellín Jose Maria Cordova Intl

Fri 1/16

6:35 am-10:37 pm

1 stop17h 02m

$438

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Sun 12/28

11:51 am-1:28 am

1 stop12h 37m

Medellín Jose Maria Cordova Intl

Wed 1/28

1:51 am-11:01 am

1 stop10h 10m

$447

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Sun 1/11

12:20 pm-9:40 pm

1 stop8h 20m

Medellín Jose Maria Cordova Intl

Tue 1/20

1:51 am-10:33 pm

2 stops21h 42m

$452

St. LouisBogotá

STL - BOG

STLBOG

Lambert-St Louis

Fri 11/14

2:42 pm-1:00 pm

2 stops21h 18m

Bogotá El Dorado

Tue 12/2

1:55 pm-10:33 pm

1 stop9h 38m

$462

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Fri 11/14

4:56 pm-9:00 am

2 stops15h 04m

Medellín Jose Maria Cordova Intl

Wed 11/19

1:00 pm-9:58 am

1 stop21h 58m

$470

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Fri 12/5

10:42 am-1:09 am

2 stops37h 27m

Medellín Jose Maria Cordova Intl

Mon 1/12

12:09 pm-10:33 pm

1 stop11h 24m

$473

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Sat 1/10

2:48 pm-12:56 am

1 stop9h 08m

Medellín Jose Maria Cordova Intl

Wed 1/21

12:09 pm-11:01 am

3 stops23h 52m

$475

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Sun 11/23

11:08 am-2:03 pm

1 stop25h 55m

Medellín Jose Maria Cordova Intl

Fri 11/28

3:14 pm-8:57 am

1 stop18h 43m

$500

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/26

Showing 1-10 of 60 results

...

Best time to book a flight from St. Louis to South America

Have a flexible travel schedule? Discover the best time to fly to South America from St. Louis with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to South America

What is the cheapest month to book a flight from St. Louis to South America?

Currently, October is the cheapest month in which you can book a flight from St. Louis to South America (average of $307). Flying from St. Louis to South America in June is currently the most expensive (average of $565). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to SA?

It’s optimal to fly from St. Louis to South America in the evening. By choosing this option you can save up to 13% on the cost of your flight, compared to a flight in the morning.

What is the cheapest day to fly from St. Louis to South America?

Travelers seeking maximum savings on their St. Louis to South America flight should consider departing on Monday at noon when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South America

Peruse reviews from past customers who have flown with Delta, LATAM Airlines, and United Airlines from St. Louis to South America to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

7,995 reviews

Reviews

1 / 20

8.0

Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Delta

7.9

Good

7,995 reviews

Delta

7.9

Good

7,995 reviews

Reviews

1 / 20

8.0

Excellent

Matthew,Oct 2025

GSP - ATL

LATAM Airlines

7.5

Good

1,871 reviews

Delta

7.9

Good

7,995 reviews

Reviews

1 / 20

8.0

Excellent

Matthew,Oct 2025

GSP - ATL

United Airlines

7.4

Good

8,996 reviews

Delta

7.9

Good

7,995 reviews

Reviews

1 / 20

8.0

Excellent

Matthew,Oct 2025

GSP - ATL

American Airlines

7.2

Good

11,033 reviews

Delta

7.9

Good

7,995 reviews

Reviews

1 / 20

8.0

Excellent

Matthew,Oct 2025

GSP - ATL

Air Canada

7.1

Good

10,370 reviews

Delta

7.9

Good

7,995 reviews

Reviews

1 / 20

8.0

Excellent

Matthew,Oct 2025

GSP - ATL

Related info for your journey

What airport do you fly from for flights from St. Louis to South America?
Located just 12.7 mi from the city center, Lambert-St Louis (STL) is the airport most travelers will use when flying to South America from St. Louis.
How long is the flight from St. Louis to South America?
A quick flight from St. Louis to South America can take about 9h 15m. Spirit Airlines provides one of the quickest options available for as low as $573. Airlines will cover a distance of 2159 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.
What are the most popular routes from St. Louis to South America?
The most popular flight routes from St. Louis to South America are Lambert-St Louis - Lima J Chavez Intl, Lambert-St Louis - Medellín Jose Maria Cordova Intl and Lambert-St Louis - Buenos Aires Ministro Pistarini.
Can I find deals for flights from St. Louis to South America that include hotel bookings?
Yes. In addition to deals on St. Louis to South America flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from St. Louis to South America?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to South America.
Can I find deals for business class flights from St. Louis to South America?
Yes. Cheapflights offers flight deals from St. Louis to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from St. Louis to South America?
Currently, October is the cheapest month in which you can book a flight from St. Louis to South America (average of $307). Flying from St. Louis to South America in June is currently the most expensive (average of $565). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

St. Louis to South America flights

Top 6 airlines flying from St. Louis to South America

Airline	Cheapest	Average	Flexibility	On-time
Spirit Airlines	Cheapest$307	Average$347	FlexibilityNo cancel fee	On-time65%
American Airlines	Cheapest$474	Average$926	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$484	Average$984	FlexibilityNo cancel fee	On-timeN/A
LATAM Airlines	Cheapest$535	Average$906	FlexibilityNo cancel fee	On-time81%
United Airlines	Cheapest$554	Average$1,072	FlexibilityNo cancel fee	On-time69%
Air Canada	Cheapest$758	Average$766	FlexibilityNo cancel fee	On-time67%

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$146+ Cheap flights from St. Louis (STL) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/31. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from St. Louis to South America with Cheapflights

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2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from St. Louis to South America

Keep the following information in mind while searching for St. Louis to South America flight deals. Data was last updated October 28, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from St. Louis to South America

Cheapest flights from St. Louis to South AmericaExplore the most affordable flight options available from St. Louis to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

Explore the most affordable flight options available from St. Louis to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from St. Louis to South America that are best for you.

Best time to book a flight from St. Louis to South America

Have a flexible travel schedule? Discover the best time to fly to South America from St. Louis with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to South America

What is the cheapest month to book a flight from St. Louis to South America?

What is the cheapest time of day to fly from STL to SA?

Find hourly flight availability from St. Louis to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 28, 2025.

What is the cheapest day to fly from St. Louis to South America?

Use this chart to determine the cheapest time to fly round-trip from St. Louis to South America. Price data was last updated on December 16, 2024.

Reviews of airlines servicing South America

Peruse reviews from past customers who have flown with Delta, LATAM Airlines, and United Airlines from St. Louis to South America to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

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Top 6 airlines flying from St. Louis to South America

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Cheapest flights from St. Louis to South America
Explore the most affordable flight options available from St. Louis to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 28, 2025.