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South America

$199+ Cheap flights from St. Louis (STL) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/8. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BOG
Jan 11 — Jan 181
Sun 1/11
Sun 1/18
1 adult, Economy
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Cheap flight deals from St. Louis to South America

Cheapest flights from St. Louis to South America
Explore the most affordable flight options available from St. Louis to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 12, 2025.

This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/286:00 amSTL - MDE
1 stop15h 05mUnited Airlines
Thu 1/2910:45 amMDE - STL
1 stop12h 15mUnited Airlines
Deal found 12/10$821
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2110:57 amSTL - LIM
2 stops35h 13mMultiple Airlines
Wed 12/2411:37 pmLIM - STL
1 stop12h 19mMultiple Airlines
Deal found 12/10$876
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/224:27 pmSTL - LIM
2 stops27h 18mMultiple Airlines
Wed 12/2411:37 pmLIM - STL
1 stop12h 19mMultiple Airlines
Deal found 12/10$885
This Kiwi.com deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/103:30 pmSTL - LIM
2 stops30h 35mMultiple Airlines
Wed 12/1711:37 pmLIM - STL
1 stop12h 19mMultiple Airlines
Deal found 12/9$904
This KAYAK deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:47 pmSTL - LIM
1 stop30h 48mSpirit Airlines
Sat 12/1311:37 pmLIM - STL
1 stop15h 15mSpirit Airlines
Deal found 12/10$905
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:05 amSTL - LIM
1 stop17h 20mAmerican Airlines
Mon 12/297:00 amLIM - STL
1 stop16h 35mAmerican Airlines
Deal found 12/10$941
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:05 amSTL - LIM
2 stops15h 20mAmerican Airlines
Tue 12/307:00 amLIM - STL
2 stops17h 55mAmerican Airlines
Deal found 12/10$946
This American Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:05 amSTL - LIM
1 stop17h 20mAmerican Airlines
Sat 12/2710:55 pmLIM - STL
1 stop19h 56mAmerican Airlines
Deal found 12/10$961
This Kiwi.com deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/224:27 pmSTL - LIM
2 stops27h 18mMultiple Airlines
Wed 12/3111:37 pmLIM - STL
1 stop12h 19mMultiple Airlines
Deal found 12/10$984
This American Airlines deal was found by Cheapflights users on 12/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/286:02 amSTL - MDE
2 stops14h 08mAmerican Airlines
Thu 1/297:00 amMDE - STL
2 stops14h 32mAmerican Airlines
Deal found 12/11$1,008
This KAYAK deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:13 pmSTL - SCL
2 stops33h 22mLATAM Airlines
Tue 1/64:35 pmSCL - STL
2 stops34h 04mLATAM Airlines
Deal found 12/10$1,096
This United Airlines deal was found by Cheapflights users on 12/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/101:00 pmSTL - GIG
2 stops17h 35mUnited Airlines
Tue 11/39:55 pmGIG - STL
1 stop14h 47mUnited Airlines
Deal found 12/10$1,165

Find flight deals from St. Louis to South America

Keep the following information in mind while searching for St. Louis to South America flight deals. Data was last updated December 12, 2025.

Round-trip from

$331
(Kiwi.com)

One-way from

$199
(Kiwi.com)

Popular in

December

Cheapest in

April

Average price

$932
From Lambert-St Louis to South America
Search Deals
One-way flight from Lambert-St Louis to South America
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($73 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($23 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
Use the filters below to find and compare flights from St. Louis to South America that are best for you.

Fly from

St. Louis

Fly to

South America

Route

Depart

Return

Price

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Wed 1/28

5:42 pm-1:55 pm

1 stop19h 13m

Medellín Jose Maria Cordova Intl

Mon 2/2

10:00 pm-11:33 pm

2 stops26h 33m

$403

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Wed 1/28

8:30 am-6:05 am

2 stops20h 35m

Medellín Jose Maria Cordova Intl

Mon 2/2

9:45 pm-7:27 pm

2 stops22h 42m

$518

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Thu 1/8

5:11 pm-1:55 pm

1 stop19h 44m

Medellín Jose Maria Cordova Intl

Tue 1/13

2:50 pm-10:34 pm

1 stop8h 44m

$531

St. LouisLima

STL - LIM

STLLIM

Lambert-St Louis

Wed 1/28

8:22 pm-10:35 pm

2 stops25h 13m

Lima J Chavez Intl

Fri 2/6

8:00 am-11:33 pm

1 stop16h 33m

$561

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Tue 3/3

11:19 am-9:10 pm

1 stop8h 51m

Medellín Jose Maria Cordova Intl

Tue 3/10

12:20 am-2:52 pm

1 stop14h 32m

$566

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Mon 1/26

8:30 am-11:15 pm

2 stops13h 45m

Medellín Jose Maria Cordova Intl

Sat 1/31

8:10 pm-10:13 am

2 stops15h 03m

$575

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Fri 2/13

11:19 am-9:10 pm

1 stop8h 51m

Medellín Jose Maria Cordova Intl

Mon 2/23

7:00 am-10:26 am

1 stop28h 26m

$588

St. LouisLima

STL - LIM

STLLIM

Lambert-St Louis

Fri 2/6

8:22 pm-10:35 pm

2 stops25h 13m

Lima J Chavez Intl

Thu 2/26

8:00 am-11:59 pm

1 stop16h 59m

$588

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Sat 1/10

9:33 am-11:39 pm

2 stops13h 06m

Medellín Jose Maria Cordova Intl

Thu 1/22

7:00 am-11:59 pm

1 stop17h 59m

$619

St. LouisLima

STL - LIM

STLLIM

Lambert-St Louis

Fri 2/6

4:05 pm-6:10 am

1 stop13h 05m

Lima J Chavez Intl

Thu 2/26

8:00 am-3:29 pm

1 stop32h 29m

$623

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/10

Showing 1-10 of 60 results
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Best time to book a flight from St. Louis to South America

Have a flexible travel schedule? Discover the best time to fly to South America from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to South America

What is the cheapest month to book a flight from St. Louis to South America?

Currently, October is the cheapest month in which you can book a flight from St. Louis to South America (average of $307). Flying from St. Louis to South America in June is currently the most expensive (average of $565). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to SA?

Find hourly flight availability from St. Louis to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 12, 2025.

It’s optimal to fly from St. Louis to South America in the evening. By choosing this option you can save up to 14% on the cost of your flight, compared to a flight at noon.

What is the cheapest day to fly from St. Louis to South America?

Use this chart to determine the cheapest time to fly round-trip from St. Louis to South America. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their St. Louis to South America flight should consider departing on Monday at noon when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated December 12, 2025.
Peruse reviews from past customers who have flown with Delta, LATAM Airlines, and United Airlines from St. Louis to South America to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,005 reviews

Boarding

8.1

Food

7.3

Entertainment

7.9

Crew

8.5

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,005 reviews
Delta
7.9
Good
8,005 reviews

Boarding

8.1

Food

7.3

Entertainment

7.9

Crew

8.5

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,889 reviews
Delta
7.9
Good
8,005 reviews

Boarding

8.1

Food

7.3

Entertainment

7.9

Crew

8.5

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,095 reviews
Delta
7.9
Good
8,005 reviews

Boarding

8.1

Food

7.3

Entertainment

7.9

Crew

8.5

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,049 reviews
Delta
7.9
Good
8,005 reviews

Boarding

8.1

Food

7.3

Entertainment

7.9

Crew

8.5

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Air Canada
7.1
Good
10,515 reviews
Delta
7.9
Good
8,005 reviews

Boarding

8.1

Food

7.3

Entertainment

7.9

Crew

8.5

Comfort

7.9

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from St. Louis to South America?

    Located just 12.7 mi from the city center, Lambert-St Louis (STL) is the airport most travelers will use when flying to South America from St. Louis.

  • How long is the flight from St. Louis to South America?

    A quick flight from St. Louis to South America can take about 8h 51m. Avianca provides one of the quickest options available for as low as $566. Airlines will cover a distance of 2436 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from St. Louis to South America one-way?

    $295 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on LATAM Airlines and Delta, with prices starting from $306 and $360, respectively.

  • What are the most popular routes from St. Louis to South America?

    The most popular flight routes from St. Louis to South America are Lambert-St Louis - Medellín Jose Maria Cordova Intl, Lambert-St Louis - Lima J Chavez Intl and Lambert-St Louis - Santiago Arturo Merino Benitez.

  • Can I find deals for flights from St. Louis to South America that include hotel bookings?

    Yes. In addition to deals on St. Louis to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to South America.

  • Can I find deals for business class flights from St. Louis to South America?

    Yes. Cheapflights offers flight deals from St. Louis to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to South America?

    Currently, October is the cheapest month in which you can book a flight from St. Louis to South America (average of $307). Flying from St. Louis to South America in June is currently the most expensive (average of $565). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for St. Louis to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from St. Louis to South America

Discover the top 6 airlines that operate flights from St. Louis to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$307Average$336FlexibilityNo cancel feeOn-time65%
American AirlinesCheapest$474Average$882FlexibilityNo cancel feeOn-time71%
DeltaCheapest$484Average$1,012FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$555Average$991FlexibilityNo cancel feeOn-time69%
LATAM AirlinesCheapest$563Average$930FlexibilityNo cancel feeOn-time81%
Air CanadaCheapest$758Average$767FlexibilityNo cancel feeOn-time67%

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