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South America

$154+ Cheap flights from St. Louis (STL) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/16. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BOG
feb. 26 — mar. 51
jue. 2/26
jue. 3/5
1 adult, Economy
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Cheap flight deals from St. Louis to South America

Cheapest flights from St. Louis to South America
Explore the most affordable flight options available from St. Louis to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 27, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 3/128:02 am
STL
-
MDE
1 stop25h 49m
Multiple Airlines
jue. 3/192:17 pm
MDE
-
STL
2 stops23h 17m
Multiple Airlines
Deal found 1/26$528
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 4/146:00 am
STL
-
CTG
1 stop7h 20m
Delta
mar. 4/212:35 pm
CTG
-
STL
1 stop8h 59m
Delta
Deal found 1/27$543
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 4/115:24 am
STL
-
CTG
1 stop8h 40m
American Airlines
sáb. 4/181:25 pm
CTG
-
STL
2 stops19h 03m
American Airlines
Deal found 1/27$548
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 2/15:42 pm
STL
-
MDE
2 stops36h 32m
Multiple Airlines
sáb. 2/72:50 pm
MDE
-
STL
1 stop9h 43m
Multiple Airlines
Deal found 1/26$561
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 3/45:52 pm
STL
-
CTG
2 stops18h 38m
American Airlines
lun. 3/91:28 pm
CTG
-
STL
2 stops19h 27m
American Airlines
Deal found 1/25$591
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 8/307:23 am
STL
-
MDE
2 stops12h 52m
American Airlines
sáb. 9/512:25 am
MDE
-
STL
2 stops11h 44m
American Airlines
Deal found 1/26$594
This FlightHub deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 3/46:00 am
STL
-
CTG
1 stop7h 17m
LATAM Airlines
lun. 3/92:30 pm
CTG
-
STL
1 stop9h 28m
LATAM Airlines
Deal found 1/25$598
This Avianca deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 1/298:30 am
STL
-
MDE
2 stops14h 05m
Avianca
jue. 2/58:10 pm
MDE
-
STL
2 stops15h 03m
Avianca
Deal found 1/25$603
This KAYAK deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 3/206:59 pm
STL
-
CTG
1 stop18h 16m
LATAM Airlines
mié. 3/252:30 pm
CTG
-
STL
1 stop9h 28m
LATAM Airlines
Deal found 1/25$608
This CheapOair deal was found by Cheapflights users on 1/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 5/167:30 am
STL
-
MDE
2 stops18h 35m
Multiple Airlines
dom. 5/3110:03 am
MDE
-
STL
2 stops26h 03m
Multiple Airlines
Deal found 1/24$608
This LATAM Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 2/236:00 am
STL
-
CTG
1 stop7h 17m
LATAM Airlines
mié. 2/253:32 pm
CTG
-
STL
1 stop9h 04m
LATAM Airlines
Deal found 1/26$610
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 5/126:00 am
STL
-
CTG
2 stops17h 01m
United Airlines
dom. 5/179:45 am
CTG
-
STL
2 stops36h 45m
United Airlines
Deal found 1/26$615

Find flight deals from St. Louis to South America

Keep the following information in mind while searching for St. Louis to South America flight deals. Data was last updated enero 27, 2026.

Round-trip from

$528
(Kiwi.com)

One-way from

$154
(Kiwi.com)

Popular in

December

Cheapest in

April

Average price

$655
From Lambert-St Louis to South America
Search Deals
One-way flight from Lambert-St Louis to South America
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($74 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($22 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 27, 2026.
Use the filters below to find and compare flights from St. Louis to South America that are best for you.

Fly from

St. Louis

Fly to

South America

Route

Depart

Return

Price

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

jue. 3/12

8:02 am-9:51 am

1 stop25h 49m

Medellín Jose Maria Cordova Intl

jue. 3/19

2:17 pm-1:34 pm

2 stops23h 17m

$528

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

mar. 4/14

6:00 am-1:20 pm

1 stop7h 20m

Cartagena Rafael Nunez

mar. 4/21

2:35 pm-11:34 pm

1 stop8h 59m

$543

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

mar. 4/14

6:00 am-1:20 pm

1 stop7h 20m

Cartagena Rafael Nunez

mar. 4/21

2:35 pm-11:34 pm

1 stop8h 59m

$543

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

mar. 4/14

3:43 pm-12:09 pm

2 stops20h 26m

Cartagena Rafael Nunez

mar. 4/21

1:25 pm-10:24 pm

1 stop8h 59m

$548

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

lun. 4/13

5:24 am-12:09 pm

1 stop6h 45m

Cartagena Rafael Nunez

lun. 4/20

3:10 pm-11:37 am

2 stops20h 27m

$548

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

sáb. 4/11

5:24 am-2:04 pm

1 stop8h 40m

Cartagena Rafael Nunez

sáb. 4/18

1:25 pm-8:28 am

2 stops19h 03m

$548

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

mar. 3/3

5:14 am-2:06 pm

1 stop7h 52m

Medellín Jose Maria Cordova Intl

mié. 3/11

2:10 pm-11:58 pm

1 stop9h 48m

$628

St. LouisQuito

STL - UIO

STLUIO

Lambert-St Louis

mié. 3/11

12:04 pm-8:35 pm

1 stop8h 31m

Quito Mariscal Sucr

mié. 3/18

11:45 pm-9:05 am

1 stop9h 20m

$636

St. LouisQuito

STL - UIO

STLUIO

Lambert-St Louis

jue. 5/14

11:06 am-10:24 pm

1 stop11h 18m

Quito Mariscal Sucr

mar. 5/26

11:59 pm-10:34 am

1 stop10h 35m

$636

St. LouisQuito

STL - UIO

STLUIO

Lambert-St Louis

mié. 3/11

9:15 am-10:04 pm

2 stops12h 49m

Quito Mariscal Sucr

mié. 3/18

6:30 am-8:16 pm

2 stops13h 46m

$640

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/25

Showing 1-10 of 60 results
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Best time to book a flight from St. Louis to South America

Have a flexible travel schedule? Discover the best time to fly to South America from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to South America

What is the cheapest month to book a flight from St. Louis to South America?

Currently, October is the cheapest month in which you can book a flight from St. Louis to South America (average of $307). Flying from St. Louis to South America in December is currently the most expensive (average of $568). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated enero 27, 2026.
Peruse reviews from past customers who have flown with Delta, LATAM Airlines, and United Airlines from St. Louis to South America to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,119 reviews

Food

7.2

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,119 reviews
Delta
7.9
Good
8,119 reviews

Food

7.2

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,912 reviews
Delta
7.9
Good
8,119 reviews

Food

7.2

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,205 reviews
Delta
7.9
Good
8,119 reviews

Food

7.2

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,197 reviews
Delta
7.9
Good
8,119 reviews

Food

7.2

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Air Canada
7.1
Good
10,660 reviews
Delta
7.9
Good
8,119 reviews

Food

7.2

Overall

7.9

Crew

8.5

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from St. Louis to South America?

    Located just 12.7 mi from the city center, Lambert-St Louis (STL) is the airport most travelers will use when flying to South America from St. Louis.

  • How long is the flight from St. Louis to South America?

    A quick flight from St. Louis to South America can take about 7h 20m. LATAM Airlines provides one of the quickest options available for as low as $543. Airlines will cover a distance of 2159 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from St. Louis to South America one-way?

    $289 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on LATAM Airlines and Delta, with prices starting from $321 and $360, respectively.

  • What are the most popular routes from St. Louis to South America?

    The most popular flight routes from St. Louis to South America are Lambert-St Louis - Cartagena Rafael Nunez, Lambert-St Louis - Buenos Aires Ministro Pistarini and Lambert-St Louis - Sao Paulo Guarulhos Intl.

  • Can I find deals for flights from St. Louis to South America that include hotel bookings?

    Yes. In addition to deals on St. Louis to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to South America.

  • Can I find deals for business class flights from St. Louis to South America?

    Yes. Cheapflights offers flight deals from St. Louis to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to South America?

    Currently, October is the cheapest month in which you can book a flight from St. Louis to South America (average of $307). Flying from St. Louis to South America in December is currently the most expensive (average of $568). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for St. Louis to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from St. Louis to South America

Discover the top 5 airlines that operate flights from St. Louis to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$474Average$861FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$474Average$885FlexibilityNo cancel feeOn-time71%
DeltaCheapest$484Average$1,035FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$536Average$948FlexibilityNo cancel feeOn-time81%
Air CanadaCheapest$758Average$767FlexibilityNo cancel feeOn-time67%

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