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South America

$112+ Cheap flights from St. Louis (STL) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/24. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BOG
Aug 3 — Aug 101
Sun 8/3
Sun 8/10
1 adult, Economy
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Cheap flight deals from St. Louis to South America

Keep the following information in mind while searching for St. Louis to South America flight deals. Data was last updated July 29, 2025.

Round-trip from

$279
(FlightHub)

One-way from

$112
(FlightHub)

Popular in

June

Cheapest in

April

Average price

$1,088
From Lambert-St Louis to South America
Search Deals
One-way flight from Lambert-St Louis to South America
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($40 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($29 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from St. Louis to South America

Cheapest flights from St. Louis to South America
Explore the most affordable flight options available from St. Louis to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

This FlightHub deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2110:35 amSTL - MDE
1 stop13h 50mSpirit Airlines
Mon 11/32:24 amMDE - STL
1 stop8h 16mSpirit Airlines
Deal found 7/27$279
This Mytrip deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/1710:37 amSTL - MDE
1 stop13h 17mMultiple Airlines
Sat 8/236:53 amMDE - STL
3 stops26h 47mMultiple Airlines
Deal found 7/27$406
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2411:51 amSTL - MDE
2 stops26h 03mDelta
Tue 11/49:15 pmMDE - STL
2 stops21h 47mDelta
Deal found 7/27$480
This LATAM Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/236:52 pmSTL - MDE
2 stops27h 36mLATAM Airlines
Wed 10/297:20 amMDE - STL
2 stops27h 06mLATAM Airlines
Deal found 7/27$488
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/31:57 pmSTL - BOG
1 stop22h 03mMultiple Airlines
Mon 10/612:55 pmBOG - STL
2 stops20h 12mMultiple Airlines
Deal found 7/29$544
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/226:00 amSTL - BOG
1 stop7h 40mDelta
Fri 8/296:35 pmBOG - STL
2 stops21h 31mDelta
Deal found 7/27$583
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2810:08 amSTL - BOG
1 stop12h 22mAmerican Airlines
Sun 8/36:30 amBOG - STL
1 stop17h 27mAmerican Airlines
Deal found 7/27$586
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/66:35 amSTL - BOG
2 stops12h 45mUnited Airlines
Fri 9/1212:14 amBOG - STL
2 stops14h 05mUnited Airlines
Deal found 7/26$587
This LATAM Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/211:04 amSTL - BOG
1 stop8h 11mLATAM Airlines
Mon 10/69:00 amBOG - STL
1 stop12h 30mLATAM Airlines
Deal found 7/29$588
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/169:19 amSTL - UIO
1 stop10h 11mDelta
Thu 9/2511:20 pmUIO - STL
1 stop18h 27mDelta
Deal found 7/28$614
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/116:15 amSTL - UIO
1 stop17h 10mUnited Airlines
Wed 9/1712:35 amUIO - STL
2 stops15h 09mUnited Airlines
Deal found 7/27$619
This LATAM Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/2610:45 amSTL - UIO
1 stop8h 15mLATAM Airlines
Mon 11/37:05 amUIO - STL
2 stops27h 35mLATAM Airlines
Deal found 7/27$624

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from St. Louis to South America that are best for you.

Fly from

St. Louis

Fly to

South America

Route

Depart

Return

Price

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Tue 10/21

10:35 am-12:25 am

1 stop13h 50m

Medellín Jose Maria Cordova Intl

Mon 11/3

2:24 am-9:40 am

1 stop8h 16m

$279

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Sun 8/17

10:37 am-11:54 pm

1 stop13h 17m

Medellín Jose Maria Cordova Intl

Sat 8/23

6:53 am-9:40 am

3 stops26h 47m

$406

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Fri 10/24

11:51 am-1:54 pm

2 stops26h 03m

Medellín Jose Maria Cordova Intl

Tue 11/4

9:15 pm-6:02 pm

2 stops21h 47m

$480

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Thu 10/23

6:52 pm-10:28 pm

2 stops27h 36m

Medellín Jose Maria Cordova Intl

Wed 10/29

7:20 am-10:26 am

2 stops27h 06m

$488

St. LouisBogotá

STL - BOG

STLBOG

Lambert-St Louis

Fri 10/3

1:57 pm-12:00 pm

1 stop22h 03m

Bogotá El Dorado

Mon 10/6

12:55 pm-9:07 am

2 stops20h 12m

$544

St. LouisBogotá

STL - BOG

STLBOG

Lambert-St Louis

Fri 8/22

6:00 am-1:40 pm

1 stop7h 40m

Bogotá El Dorado

Fri 8/29

6:35 pm-4:06 pm

2 stops21h 31m

$583

St. LouisBogotá

STL - BOG

STLBOG

Lambert-St Louis

Fri 10/3

7:16 am-10:40 pm

1 stop15h 24m

Bogotá El Dorado

Sun 10/5

12:25 am-4:17 pm

1 stop15h 52m

$586

St. LouisBogotá

STL - BOG

STLBOG

Lambert-St Louis

Sat 9/6

6:35 am-7:20 pm

2 stops12h 45m

Bogotá El Dorado

Fri 9/12

12:14 am-2:19 pm

2 stops14h 05m

$587

St. LouisQuito

STL - UIO

STLUIO

Lambert-St Louis

Tue 9/16

11:05 am-11:25 pm

1 stop12h 20m

Quito Mariscal Sucr

Wed 9/24

12:35 am-6:57 pm

1 stop18h 22m

$614

St. LouisQuito

STL - UIO

STLUIO

Lambert-St Louis

Sun 10/26

1:30 pm-6:55 pm

1 stop29h 25m

Quito Mariscal Sucr

Sun 11/2

12:55 am-4:10 pm

1 stop16h 15m

$622

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/27

Showing 1-10 of 60 results
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Best time to book a flight from St. Louis to South America

Have a flexible travel schedule? Discover the best time to fly to South America from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to South America

What is the cheapest month to book a flight from St. Louis to South America?

Currently, May is the cheapest month in which you can book a flight from St. Louis to South America (average of $359). Flying from St. Louis to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to SA?

Find hourly flight availability from St. Louis to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 29, 2025.

When flying from St. Louis to South America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated July 29, 2025.
Peruse reviews from past customers who have flown with Delta, LATAM Airlines, and Copa Airlines from St. Louis to South America to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,977 reviews

Comfort

7.9

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,977 reviews
Delta
8.0
Very good
7,977 reviews

Comfort

7.9

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,821 reviews
Delta
8.0
Very good
7,977 reviews

Comfort

7.9

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Copa Airlines
7.5
Good
1,493 reviews
Delta
8.0
Very good
7,977 reviews

Comfort

7.9

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,899 reviews
Delta
8.0
Very good
7,977 reviews

Comfort

7.9

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
GOL
7.3
Good
1,091 reviews
Delta
8.0
Very good
7,977 reviews

Comfort

7.9

Crew

8.5

Boarding

8.2

Entertainment

7.9

Food

7.3

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from St. Louis to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from St. Louis to South America?

    Located just 12.7 mi from the city center, Lambert-St Louis (STL) is the airport most travelers will use when flying to South America from St. Louis.

  • What are the cheapest airlines to fly from St. Louis to South America one-way?

    $112 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on Avianca and LATAM Airlines, with prices starting from $245 and $275, respectively.

  • What are the most popular routes from St. Louis to South America?

    The most popular flight routes from St. Louis to South America are Lambert-St Louis - Lima J Chavez Intl, Lambert-St Louis - Medellín Jose Maria Cordova Intl and Lambert-St Louis - Buenos Aires Ministro Pistarini.

  • Can I find deals for flights from St. Louis to South America that include hotel bookings?

    Yes. In addition to deals on St. Louis to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to South America.

  • Can I find deals for business class flights from St. Louis to South America?

    Yes. Cheapflights offers flight deals from St. Louis to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to South America?

    Currently, May is the cheapest month in which you can book a flight from St. Louis to South America (average of $359). Flying from St. Louis to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for St. Louis to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from St. Louis to South America

Discover the top 6 airlines that operate flights from St. Louis to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$336Average$432FlexibilityNo cancel feeOn-time65%
United AirlinesCheapest$399Average$944FlexibilityNo cancel feeOn-time69%
LATAM AirlinesCheapest$403Average$831FlexibilityNo cancel feeOn-time81%
DeltaCheapest$448Average$953FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$474Average$887FlexibilityNo cancel feeOn-time71%
Air CanadaCheapest$758Average$767FlexibilityNo cancel feeOn-time67%

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