$179+ Cheap flights from Columbus (CMH) to South America
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/1. Fares are subject to change and may not be available on all flights or dates of travel.
CMH — BOG
May 18 — May 251
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Columbus to South America with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Columbus to South America
Cheapest
Best
Last-minute
One-way
Cheapest flights from Columbus to South AmericaExplore the most affordable flight options available from Columbus to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 18, 2026.
Explore the most affordable flight options available from Columbus to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 18, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/316:00 am
CMH
- CTG
1 stop7h 26m
Multiple Airlines
Wed 6/101:31 pm
CTG
- CMH
2 stops26h 34m
Multiple Airlines
Deal found 4/15![Multiple Airlines logo]()
$371
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/158:48 pm
CMH
- MDE
1 stop17h 12m
Multiple Airlines
Wed 6/101:55 pm
MDE
- CMH
2 stops26h 10m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$380
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:43 pm
CMH
- MDE
1 stop17h 17m
Multiple Airlines
Wed 6/101:55 pm
MDE
- CMH
2 stops26h 10m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$391
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/88:48 pm
CMH
- MDE
1 stop17h 12m
Multiple Airlines
Sat 5/161:55 pm
MDE
- CMH
2 stops26h 15m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$393
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/107:20 pm
CMH
- MDE
1 stop18h 40m
Multiple Airlines
Wed 6/171:55 pm
MDE
- CMH
2 stops26h 10m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$397
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/316:00 am
CMH
- CTG
1 stop7h 26m
Spirit Airlines
Sun 6/71:31 pm
CTG
- CMH
2 stops22h 11m
Spirit Airlines
Deal found 4/15![Spirit Airlines logo]()
$404
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:43 pm
CMH
- MDE
1 stop17h 17m
Multiple Airlines
Wed 6/171:55 pm
MDE
- CMH
2 stops26h 10m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$408
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/39:21 pm
CMH
- MDE
1 stop16h 39m
Spirit Airlines
Sun 5/171:55 pm
MDE
- CMH
1 stop21h 47m
Spirit Airlines
Deal found 4/17![Spirit Airlines logo]()
$413
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/107:20 pm
CMH
- MDE
1 stop18h 40m
Multiple Airlines
Mon 6/151:55 pm
MDE
- CMH
2 stops26h 10m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$416
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:43 pm
CMH
- MDE
1 stop17h 17m
Multiple Airlines
Mon 6/151:55 pm
MDE
- CMH
2 stops26h 10m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$427
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:00 am
CMH
- CTG
1 stop7h 26m
Multiple Airlines
Wed 6/101:31 pm
CTG
- CMH
2 stops26h 34m
Multiple Airlines
Deal found 4/15![Multiple Airlines logo]()
$443
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/316:00 am
CMH
- CTG
1 stop7h 26m
Spirit Airlines
Thu 6/111:31 pm
CTG
- CMH
1 stop9h 25m
Spirit Airlines
Deal found 4/15![Spirit Airlines logo]()
$445
Best flights from Columbus to South AmericaDiscover carefully curated flight deals from Columbus to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 18, 2026.
Discover carefully curated flight deals from Columbus to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 18, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/246:05 pm
CMH
- MDE
2 stops19h 38m
Multiple Airlines
Fri 5/292:06 pm
MDE
- CMH
1 stop8h 50m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$462
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/41:37 pm
CMH
- MDE
1 stop24h 23m
Spirit Airlines
Mon 6/81:55 pm
MDE
- CMH
1 stop21h 47m
Spirit Airlines
Deal found 4/17![Spirit Airlines logo]()
$473
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/175:25 pm
CMH
- CTG
2 stops20h 10m
American Airlines
Wed 8/123:15 pm
CTG
- CMH
2 stops18h 46m
American Airlines
Deal found 4/16![American Airlines logo]()
$577
This United Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2711:43 am
CMH
- MDE
1 stop10h 27m
United Airlines
Mon 6/89:45 am
MDE
- CMH
1 stop13h 14m
United Airlines
Deal found 4/17![United Airlines logo]()
$633
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/3010:10 am
CMH
- CTG
2 stops33h 20m
Delta
Wed 6/105:30 am
CTG
- CMH
2 stops18h 24m
Delta
Deal found 4/15![Delta logo]()
$644
This Copa Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/46:07 am
CMH
- LIM
2 stops17h 38m
Copa Airlines
Tue 10/204:00 am
LIM
- CMH
2 stops28h 35m
Copa Airlines
Deal found 4/15![Copa Airlines logo]()
$732
This KAYAK deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/167:01 am
CMH
- LIM
2 stops14h 19m
LATAM Airlines
Mon 6/2212:10 am
LIM
- CMH
2 stops17h 57m
LATAM Airlines
Deal found 4/15![LATAM Airlines logo]()
$801
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:35 pm
CMH
- MDE
2 stops38h 40m
Multiple Airlines
Fri 5/152:06 pm
MDE
- CMH
1 stop8h 50m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$497
This KAYAK deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/106:13 pm
CMH
- CUZ
2 stops17h 52m
GOL
Wed 7/154:45 pm
CUZ
- CMH
2 stops19h 17m
GOL
Deal found 4/17![GOL logo]()
$1,101
This Cheapflightsfares deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/38:45 pm
CMH
- MDE
1 stop17h 19m
Spirit Airlines
Tue 7/72:26 pm
MDE
- CMH
1 stop7h 57m
Spirit Airlines
Deal found 4/15![Spirit Airlines logo]()
$571
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/164:00 pm
CMH
- CTG
2 stops21h 35m
American Airlines
Tue 8/183:15 pm
CTG
- CMH
2 stops20h 04m
American Airlines
Deal found 4/16![American Airlines logo]()
$577
This Air Canada deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/262:15 pm
CMH
- EZE
2 stops23h 15m
Air Canada
Wed 8/124:35 pm
EZE
- CMH
3 stops47h 47m
Air Canada
Deal found 4/17![Air Canada logo]()
$1,171
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/306:00 am
CMH
- MDE
1 stop7h 43m
Spirit Airlines
Tue 6/21:55 pm
MDE
- CMH
1 stop21h 47m
Spirit Airlines
Deal found 4/15![Spirit Airlines logo]()
$577
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1211:37 am
CMH
- MDE
1 stop10h 33m
United Airlines
Mon 6/89:45 am
MDE
- CMH
2 stops21h 53m
United Airlines
Deal found 4/13![United Airlines logo]()
$638
This Mytrip deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:00 am
CMH
- CTG
1 stop7h 26m
Multiple Airlines
Sat 5/2312:16 pm
CTG
- CMH
3 stops34h 40m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$592
This Delta deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/157:00 pm
CMH
- CTG
1 stop19h 15m
Delta
Sat 5/232:30 pm
CTG
- CMH
1 stop8h 45m
Delta
Deal found 4/17![Delta logo]()
$660
This American Airlines deal was found by Cheapflights users on 4/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/251:01 pm
CMH
- MDE
2 stops11h 57m
American Airlines
Fri 8/146:00 am
MDE
- CMH
1 stop17h 58m
American Airlines
Deal found 4/16![American Airlines logo]()
$614
This Expedia deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:00 am
CMH
- CTG
1 stop7h 26m
Spirit Airlines
Fri 6/51:31 pm
CTG
- CMH
1 stop9h 25m
Spirit Airlines
Deal found 4/14![Spirit Airlines logo]()
$579
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/137:00 am
CMH
- MDE
2 stops15h 10m
United Airlines
Wed 6/109:45 am
MDE
- CMH
2 stops21h 53m
United Airlines
Deal found 4/13![United Airlines logo]()
$638
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/3010:10 am
CMH
- CTG
2 stops34h 25m
Delta
Sat 6/69:25 am
CTG
- CMH
2 stops22h 34m
Delta
Deal found 4/15![Delta logo]()
$664
This Mytrip deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/91:37 pm
CMH
- MDE
2 stops17h 43m
Multiple Airlines
Fri 6/129:04 am
MDE
- CMH
3 stops26h 38m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$626
This Copa Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/911:03 am
CMH
- LIM
2 stops15h 17m
Copa Airlines
Mon 7/204:40 pm
LIM
- CMH
2 stops16h 17m
Copa Airlines
Deal found 4/13![Copa Airlines logo]()
$804
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/95:08 am
CMH
- GYE
1 stop9h 23m
American Airlines
Thu 7/302:37 pm
GYE
- CMH
1 stop21h 20m
American Airlines
Deal found 4/14![American Airlines logo]()
$681
This United Airlines deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:30 am
CMH
- UIO
1 stop23h 30m
United Airlines
Mon 8/247:25 am
UIO
- CMH
2 stops24h 10m
United Airlines
Deal found 4/13![United Airlines logo]()
$687
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/236:00 am
CMH
- GYE
2 stops17h 37m
American Airlines
Tue 7/212:37 pm
GYE
- CMH
2 stops17h 07m
American Airlines
Deal found 4/14![American Airlines logo]()
$689
This United Airlines deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2911:35 am
CMH
- CTG
2 stops12h 25m
United Airlines
Wed 6/109:45 am
CTG
- CMH
2 stops24h 17m
United Airlines
Deal found 4/15![United Airlines logo]()
$727
This LATAM Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/611:45 am
CMH
- EZE
2 stops17h 25m
LATAM Airlines
Mon 9/148:10 pm
EZE
- CMH
1 stop23h 39m
LATAM Airlines
Deal found 4/17![LATAM Airlines logo]()
$969
This Delta deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/186:00 am
CMH
- LIM
2 stops15h 20m
Delta
Tue 6/238:55 am
LIM
- CMH
2 stops14h 59m
Delta
Deal found 4/15![Delta logo]()
$801
This American Airlines deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/101:12 pm
CMH
- UIO
2 stops11h 47m
American Airlines
Mon 8/2411:56 pm
UIO
- CMH
1 stop16h 04m
American Airlines
Deal found 4/14![American Airlines logo]()
$701
This LATAM Airlines deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/262:43 pm
CMH
- EZE
1 stop18h 02m
LATAM Airlines
Wed 8/128:10 pm
EZE
- CMH
1 stop23h 39m
LATAM Airlines
Deal found 4/17![LATAM Airlines logo]()
$969
Last-minute flights from Columbus to South AmericaDiscover last-minute flight deals from Columbus to South America. Data last updated April 18, 2026 and is based on user searches.
Discover last-minute flight deals from Columbus to South America. Data last updated April 18, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/39:21 pm
CMH
- MDE
1 stop16h 39m
Spirit Airlines
Sun 5/171:55 pm
MDE
- CMH
1 stop21h 47m
Spirit Airlines
Deal found 4/17![Spirit Airlines logo]()
$413
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/88:48 pm
CMH
- MDE
1 stop17h 12m
Multiple Airlines
Sat 5/161:55 pm
MDE
- CMH
2 stops26h 15m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$393
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/107:20 pm
CMH
- MDE
1 stop18h 40m
Multiple Airlines
Wed 6/171:55 pm
MDE
- CMH
2 stops26h 10m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$397
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/107:20 pm
CMH
- MDE
1 stop18h 40m
Multiple Airlines
Mon 6/151:55 pm
MDE
- CMH
2 stops26h 10m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$416
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:43 pm
CMH
- MDE
1 stop17h 17m
Multiple Airlines
Wed 6/101:55 pm
MDE
- CMH
2 stops26h 10m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$391
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:43 pm
CMH
- MDE
1 stop17h 17m
Multiple Airlines
Wed 6/171:55 pm
MDE
- CMH
2 stops26h 10m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$408
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:43 pm
CMH
- MDE
1 stop17h 17m
Multiple Airlines
Mon 6/151:55 pm
MDE
- CMH
2 stops26h 10m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$427
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/158:48 pm
CMH
- MDE
1 stop17h 12m
Multiple Airlines
Wed 6/101:55 pm
MDE
- CMH
2 stops26h 10m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$380
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:00 am
CMH
- CTG
1 stop7h 26m
Multiple Airlines
Wed 6/101:31 pm
CTG
- CMH
2 stops26h 34m
Multiple Airlines
Deal found 4/15![Multiple Airlines logo]()
$454
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/316:00 am
CMH
- CTG
1 stop7h 26m
Multiple Airlines
Wed 6/101:31 pm
CTG
- CMH
2 stops26h 34m
Multiple Airlines
Deal found 4/15![Multiple Airlines logo]()
$371
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/316:00 am
CMH
- CTG
1 stop7h 26m
Spirit Airlines
Sun 6/71:31 pm
CTG
- CMH
2 stops22h 11m
Spirit Airlines
Deal found 4/15![Spirit Airlines logo]()
$404
This Kiwi.com deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/316:00 am
CMH
- CTG
1 stop7h 26m
Spirit Airlines
Thu 6/111:31 pm
CTG
- CMH
1 stop9h 25m
Spirit Airlines
Deal found 4/15![Spirit Airlines logo]()
$445
One-way flights from Columbus to South AmericaSearch for one-way flight options from Columbus to South America. Find affordable one-way fares based on user searches. Data last updated April 18, 2026.
Search for one-way flight options from Columbus to South America. Find affordable one-way fares based on user searches. Data last updated April 18, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:00 am
CMH
- GYE
1 stop18h 04m
Spirit Airlines
Deal found 4/13![Spirit Airlines logo]()
$179
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/16:35 pm
CMH
- GYE
3 stops39h 20m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$181
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/228:48 pm
CMH
- CTG
2 stops23h 49m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$187
This Kiwi.com deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/286:07 pm
CMH
- MDE
3 stops30h 23m
Multiple Airlines
Deal found 4/17![Multiple Airlines logo]()
$222
This Cheapflightsfares deal was found by Cheapflights users on 4/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:00 am
CMH
- MDE
1 stop8h 25m
Spirit Airlines
Deal found 4/17![Spirit Airlines logo]()
$230
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/61:37 pm
CMH
- GYE
2 stops34h 27m
Spirit Airlines
Deal found 4/14![Spirit Airlines logo]()
$248
This CheapOair deal was found by Cheapflights users on 4/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/226:00 am
CMH
- CTG
1 stop7h 26m
Spirit Airlines
Deal found 4/15![Spirit Airlines logo]()
$285
This Kiwi.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/188:48 pm
CMH
- LIM
3 stops28h 42m
Multiple Airlines
Deal found 4/14![Multiple Airlines logo]()
$303
This Cheapflightsfares deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:00 am
CMH
- LIM
1 stop18h 11m
Spirit Airlines
Deal found 4/14![Spirit Airlines logo]()
$305
This Super.com deal was found by Cheapflights users on 4/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:00 am
CMH
- LIM
1 stop18h 11m
Spirit Airlines
Deal found 4/14![Spirit Airlines logo]()
$333
This oojo deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3010:36 am
CMH
- MDE
2 stops12h 49m
Avianca
Deal found 4/13![Avianca logo]()
$340
This Kiwi.com deal was found by Cheapflights users on 4/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/237:00 pm
CMH
- LIM
3 stops31h 02m
Multiple Airlines
Deal found 4/13![Multiple Airlines logo]()
$373
Find flight deals from Columbus to South America
Keep the following information in mind while searching for Columbus to South America flight deals. Data was last updated April 18, 2026.
Round-trip from | $371 (Kiwi.com) |
|---|---|
One-way from | $179 (Cheapflightsfares) |
Popular in | February |
Cheapest in | October |
Average price | $388 |
Cheapflights Fare Finder
Customize your flight search to find flights from Columbus to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 18, 2026.
Use the filters below to find and compare flights from Columbus Airport to South America that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ColumbusMedellín
CMH - MDE
CMHMDE
Columbus
Sun 5/24
6:05 pm-12:43 pm
2 stops19h 38m
Medellín Jose Maria Cordova Intl
Fri 5/29
2:06 pm-11:56 pm
1 stop8h 50m
$462
ColumbusMedellín
CMH - MDE
CMHMDE
Columbus
Mon 5/4
1:37 pm-1:00 pm
1 stop24h 23m
Medellín Jose Maria Cordova Intl
Mon 6/8
1:55 pm-12:42 pm
1 stop21h 47m
$473
ColumbusMedellín
CMH - MDE
CMHMDE
Columbus
Fri 5/1
6:35 pm-8:15 am
2 stops38h 40m
Medellín Jose Maria Cordova Intl
Fri 5/15
2:06 pm-11:56 pm
1 stop8h 50m
$497
ColumbusMedellín
CMH - MDE
CMHMDE
Columbus
Fri 7/3
8:45 pm-1:04 pm
1 stop17h 19m
Medellín Jose Maria Cordova Intl
Tue 7/7
2:26 pm-11:23 pm
1 stop7h 57m
$571
ColumbusCartagena
CMH - CTG
CMHCTG
Columbus
Wed 6/17
5:25 pm-12:35 pm
2 stops20h 10m
Cartagena Rafael Nunez
Wed 8/12
3:15 pm-11:01 am
2 stops18h 46m
$577
ColumbusCartagena
CMH - CTG
CMHCTG
Columbus
Tue 6/16
4:00 pm-12:35 pm
2 stops21h 35m
Cartagena Rafael Nunez
Tue 8/18
3:15 pm-12:19 pm
2 stops20h 04m
$577
ColumbusMedellín
CMH - MDE
CMHMDE
Columbus
Sat 5/30
6:00 am-12:43 pm
1 stop7h 43m
Medellín Jose Maria Cordova Intl
Tue 6/2
1:55 pm-12:42 pm
1 stop21h 47m
$577
Quickest round-trip
ColumbusCartagena
CMH - CTG
CMHCTG
Columbus
Fri 5/29
6:00 am-12:26 pm
1 stop7h 26m
Cartagena Rafael Nunez
Fri 6/5
1:31 pm-11:56 pm
1 stop9h 25m
$579
ColumbusCartagena
CMH - CTG
CMHCTG
Columbus
Fri 5/15
6:00 am-12:26 pm
1 stop7h 26m
Cartagena Rafael Nunez
Sat 5/23
12:16 pm-11:56 pm
3 stops34h 40m
$592
ColumbusMedellín
CMH - MDE
CMHMDE
Columbus
Sat 7/25
1:01 pm-11:58 pm
2 stops11h 57m
Medellín Jose Maria Cordova Intl
Fri 8/14
6:00 am-12:58 am
1 stop17h 58m
$614
Showing 1-10 of 57 resultsSorted by cheapest first
Best time to book a flight from Columbus to South America
Have a flexible travel schedule? Discover the best time to fly to South America from Columbus with our price prediction graph.
CMH-GYE
CMH-CTG
CMH-MDE
CMH-LIM
CMH-CUZ
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Columbus Airport to South America
CMH-0SA
CMH-GYE
CMH-CTG
CMH-MDE
CMH-LIM
What is the cheapest month to book a flight from Columbus Airport to South America?
Currently, October is the cheapest month in which you can book a flight from Columbus Airport to South America (average of $225). Flying from Columbus Airport to South America in June is currently the most expensive (average of $381). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing South America
Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated April 18, 2026.
Get a feel of what it's like to fly with Delta,LATAM Airlines, andUnited Airlines from Columbus Airport to South America by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.9
Crew
8.5
Entertainment
7.8
Overall
7.9
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Crew
8.5
Entertainment
7.8
Overall
7.9
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Crew
8.5
Entertainment
7.8
Overall
7.9
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Crew
8.5
Entertainment
7.8
Overall
7.9
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Crew
8.5
Entertainment
7.8
Overall
7.9
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Comfort
7.9
Crew
8.5
Entertainment
7.8
Overall
7.9
Boarding
8.1
Food
7.2
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Columbus to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top countries
Top destinations
Alternative routes for Columbus to South America
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South America by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Columbus to South America by cabin class
Find flights from Columbus to South America, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Columbus and South America flights
Browse other Columbus and South America flight options. Last updated on April 18, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Fly to South America countries
Consider these flights traveling to countries located in South America.
Columbus to South America flights
Consider these flights traveling from Columbus to South America.
Top 5 airlines flying from Columbus to South America
Discover the top 5 airlines that operate flights from Columbus to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$244 | Average$410 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$552 | Average$800 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$552 | Average$767 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$658 | Average$948 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$962 | Average$1,449 | FlexibilityNo cancel fee | On-time69% |