How long is the flight from Columbus Airport to South America?

Spirit Airlines and United Airlines can get you from Columbus Airport to South America in just under 9h 11m. Your travel time can differ by up to 21h 53m. Airlines will cover a distance of 2382 mi. Both multi-stop and nonstop flights can be found to your destination and back.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

What are the most popular routes from Columbus Airport to South America?

When deciding which route to take from Columbus Airport to South America consider Columbus - Medellín Jose Maria Cordova Intl, Columbus - Cartagena Rafael Nunez or Columbus - Buenos Aires Ministro Pistarini as they are the most popular.

What are the most popular airlines that fly from Columbus Airport to South America?

When booking a flight from Columbus Airport to South America, you may want to consider flying on American Airlines, Delta or LATAM Airlines as they are the most popular for this route.

Can I find deals for flights from Columbus to South America that include hotel bookings?

Yes. In addition to deals on Columbus to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Columbus to South America?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbus to South America.

Can I find deals for business class flights from Columbus to South America?

Yes. Cheapflights offers flight deals from Columbus to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$119+ Cheap Flights from Columbus Airport to South America

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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

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Cheap flight deals from Columbus to South America

Round-trip from	$282 (Expedia)
One-way from	$119 (Travelocity)

From Columbus to South America

Search Deals

One-way flight from Columbus to South America

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Find flight deals from Columbus to South America

Cheapest flights from Columbus to South America
Explore the most affordable flight options available from Columbus to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

Thu 10/305:00 amCMH - BOG

1 stop9h 15mSpirit Airlines

Thu 11/61:57 pmBOG - CMH

1 stop18h 18mSpirit Airlines

Deal found 9/15

$282

Thu 10/95:00 amCMH - MDE

1 stop9h 11mSpirit Airlines

Fri 10/241:16 amMDE - CMH

1 stop9h 42mSpirit Airlines

Deal found 9/15

$291

Sat 11/15:00 amCMH - CTG

1 stop8h 25mSpirit Airlines

Sat 11/82:16 pmCTG - CMH

1 stop6h 56mSpirit Airlines

Deal found 9/17

$305

Sat 11/86:45 amCMH - CTG

1 stop6h 23mSpirit Airlines

Thu 11/132:16 pmCTG - CMH

1 stop6h 56mSpirit Airlines

Deal found 9/16

$316

Fri 10/315:00 amCMH - BOG

1 stop9h 15mSpirit Airlines

Fri 11/73:05 pmBOG - CMH

1 stop30h 07mSpirit Airlines

Deal found 9/16

$317

Sun 11/96:45 amCMH - CTG

1 stop6h 23mSpirit Airlines

Thu 11/132:16 pmCTG - CMH

1 stop6h 56mSpirit Airlines

Deal found 9/17

$320

Tue 9/305:15 amCMH - BOG

1 stop8h 55mSpirit Airlines

Wed 10/152:10 pmBOG - CMH

2 stops20h 13mSpirit Airlines

Deal found 9/16

$320

Thu 10/235:00 amCMH - MDE

1 stop20h 21mSpirit Airlines

Sat 10/251:16 amMDE - CMH

1 stop9h 42mSpirit Airlines

Deal found 9/15

$335

Thu 10/95:00 amCMH - MDE

1 stop9h 11mSpirit Airlines

Thu 10/302:22 pmMDE - CMH

1 stop20h 36mSpirit Airlines

Deal found 9/17

$347

Wed 11/56:45 amCMH - CTG

1 stop6h 23mSpirit Airlines

Mon 11/102:16 pmCTG - CMH

1 stop6h 56mSpirit Airlines

Deal found 9/15

$363

Wed 9/245:15 amCMH - BOG

1 stop8h 55mSpirit Airlines

Sat 10/1112:55 pmBOG - CMH

2 stops22h 03mSpirit Airlines

Deal found 9/15

$363

Tue 10/148:42 amCMH - MDE

2 stops40h 39mSpirit Airlines

Wed 10/221:59 pmMDE - CMH

2 stops20h 59mSpirit Airlines

Deal found 9/15

$364

Best flights from Columbus to South America
Discover carefully curated flight deals from Columbus to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2025.

Thu 10/95:00 amCMH - MDE

1 stop9h 11mSpirit Airlines

Fri 10/241:16 amMDE - CMH

1 stop9h 42mSpirit Airlines

Deal found 9/15

$291

Tue 9/305:15 amCMH - BOG

3 stops27h 01mMultiple Airlines

Wed 10/154:25 pmBOG - CMH

2 stops18h 33mMultiple Airlines

Deal found 9/16

$364

Thu 10/95:00 amCMH - MDE

1 stop9h 11mSpirit Airlines

Wed 10/291:16 amMDE - CMH

1 stop9h 42mSpirit Airlines

Deal found 9/15

$291

Thu 11/276:30 amCMH - GYE

2 stops31h 04mUnited Airlines

Sun 12/712:20 pmGYE - CMH

2 stops34h 09mUnited Airlines

Deal found 9/17

$636

Mon 9/2910:32 amCMH - GYE

2 stops40h 33mAvianca

Mon 10/203:15 amGYE - CMH

2 stops29h 29mAvianca

Deal found 9/15

$669

Fri 10/315:00 amCMH - BOG

1 stop9h 15mSpirit Airlines

Fri 11/73:05 pmBOG - CMH

1 stop30h 07mSpirit Airlines

Deal found 9/16

$317

Tue 10/712:00 pmCMH - SCL

1 stop16h 45mLATAM Airlines

Mon 10/139:40 pmSCL - CMH

1 stop14h 33mLATAM Airlines

Deal found 9/16

$732

Tue 11/49:30 amCMH - GRU

1 stop23h 05mAir Canada

Wed 11/129:30 pmGRU - CMH

1 stop25h 26mAir Canada

Deal found 9/14

$744

Thu 10/235:00 amCMH - MDE

1 stop14h 50mMultiple Airlines

Sun 10/261:00 pmMDE - CMH

1 stop21h 58mMultiple Airlines

Deal found 9/15

$373

Wed 10/16:30 pmCMH - SCL

1 stop12h 25mAmerican Airlines

Tue 10/79:55 pmSCL - CMH

1 stop21h 50mAmerican Airlines

Deal found 9/16

$764

Thu 10/235:00 amCMH - MDE

1 stop20h 21mSpirit Airlines

Sat 10/251:16 amMDE - CMH

1 stop9h 42mSpirit Airlines

Deal found 9/15

$335

Sun 11/95:22 pmCMH - CTG

3 stops24h 32mMultiple Airlines

Thu 11/132:16 pmCTG - CMH

1 stop6h 56mMultiple Airlines

Deal found 9/16

$402

Thu 10/305:00 amCMH - BOG

1 stop9h 15mSpirit Airlines

Thu 11/63:05 pmBOG - CMH

2 stops16h 36mSpirit Airlines

Deal found 9/15

$339

Sat 11/19:00 amCMH - EZE

2 stops21h 59mCopa Airlines

Sat 11/85:16 amEZE - CMH

2 stops30h 31mCopa Airlines

Deal found 9/16

$972

Fri 10/315:00 amCMH - BOG

1 stop9h 15mMultiple Airlines

Fri 11/71:00 pmBOG - CMH

3 stops23h 15mMultiple Airlines

Deal found 9/16

$404

Sun 11/95:22 pmCMH - CTG

2 stops19h 46mSpirit Airlines

Thu 11/132:16 pmCTG - CMH

1 stop6h 56mSpirit Airlines

Deal found 9/17

$344

Mon 10/65:00 amCMH - CTG

1 stop8h 25mMultiple Airlines

Wed 10/151:42 pmCTG - CMH

3 stops21h 16mMultiple Airlines

Deal found 9/15

$410

Tue 11/46:25 pmCMH - EZE

1 stop12h 35mDelta

Thu 11/138:55 pmEZE - CMH

1 stop17h 57mDelta

Deal found 9/15

$1,101

Thu 11/136:45 amCMH - MDE

1 stop11h 19mSpirit Airlines

Fri 11/213:11 pmMDE - CMH

1 stop18h 44mSpirit Airlines

Deal found 9/17

$371

Fri 10/316:21 pmCMH - CTG

3 stops30h 52mMultiple Airlines

Fri 11/72:16 pmCTG - CMH

1 stop6h 56mMultiple Airlines

Deal found 9/15

$424

Mon 2/164:40 pmCMH - GYE

2 stops42h 38mUnited Airlines

Sun 3/112:20 pmGYE - CMH

2 stops33h 52mUnited Airlines

Deal found 9/17

$662

Wed 9/245:15 amCMH - BOG

1 stop8h 55mSpirit Airlines

Sat 10/112:10 pmBOG - CMH

1 stop20h 48mSpirit Airlines

Deal found 9/16

$374

Mon 9/296:00 amCMH - GYE

2 stops45h 05mAvianca

Thu 10/233:15 amGYE - CMH

2 stops29h 15mAvianca

Deal found 9/14

$678

Sat 11/17:43 pmCMH - CTG

3 stops26h 38mMultiple Airlines

Sat 11/82:16 pmCTG - CMH

1 stop6h 56mMultiple Airlines

Deal found 9/17

$427

Tue 10/712:00 pmCMH - SCL

1 stop16h 45mLATAM Airlines

Sun 10/1210:50 pmSCL - CMH

1 stop19h 50mLATAM Airlines

Deal found 9/16

$735

Fri 10/316:21 pmCMH - CTG

2 stops19h 04mSpirit Airlines

Fri 11/72:16 pmCTG - CMH

1 stop6h 56mSpirit Airlines

Deal found 9/15

$379

Fri 11/286:20 amCMH - GYE

2 stops28h 58mUnited Airlines

Sun 12/72:35 pmGYE - CMH

2 stops31h 54mUnited Airlines

Deal found 9/15

$683

Sat 11/86:45 amCMH - CTG

1 stop6h 23mMultiple Airlines

Wed 11/124:35 amCTG - CMH

2 stops27h 40mMultiple Airlines

Deal found 9/16

$436

Wed 10/111:54 amCMH - SCL

1 stop18h 51mLATAM Airlines

Mon 10/68:50 amSCL - CMH

2 stops16h 09mLATAM Airlines

Deal found 9/16

$748

Tue 10/148:19 pmCMH - MDE

2 stops29h 02mSpirit Airlines

Wed 10/222:22 pmMDE - CMH

1 stop20h 36mSpirit Airlines

Deal found 9/15

$386

Last-minute flights from Columbus to South America
Discover last-minute flight deals from Columbus to South America. Data last updated September 17, 2025 and is based on user searches.

Wed 9/245:15 amCMH - BOG

1 stop8h 55mSpirit Airlines

Sat 10/1112:55 pmBOG - CMH

2 stops22h 03mSpirit Airlines

Deal found 9/15

$363

Tue 9/305:15 amCMH - BOG

1 stop8h 55mSpirit Airlines

Wed 10/152:10 pmBOG - CMH

2 stops20h 13mSpirit Airlines

Deal found 9/16

$320

Tue 9/305:15 amCMH - BOG

3 stops27h 01mMultiple Airlines

Wed 10/154:25 pmBOG - CMH

2 stops18h 33mMultiple Airlines

Deal found 9/16

$364

Mon 10/65:00 amCMH - CTG

1 stop8h 25mMultiple Airlines

Wed 10/159:48 pmCTG - CMH

2 stops13h 10mMultiple Airlines

Deal found 9/15

$373

Thu 10/95:00 amCMH - MDE

1 stop9h 11mSpirit Airlines

Fri 10/241:16 amMDE - CMH

1 stop9h 42mSpirit Airlines

Deal found 9/15

$291

Thu 10/95:00 amCMH - MDE

1 stop9h 11mSpirit Airlines

Thu 10/302:22 pmMDE - CMH

1 stop20h 36mSpirit Airlines

Deal found 9/17

$347

Tue 10/148:42 amCMH - MDE

2 stops40h 39mSpirit Airlines

Wed 10/221:59 pmMDE - CMH

2 stops20h 59mSpirit Airlines

Deal found 9/15

$364

Thu 10/235:00 amCMH - MDE

1 stop20h 21mSpirit Airlines

Sat 10/251:16 amMDE - CMH

1 stop9h 42mSpirit Airlines

Deal found 9/15

$335

Thu 10/235:00 amCMH - MDE

1 stop14h 50mMultiple Airlines

Sun 10/261:00 pmMDE - CMH

1 stop21h 58mMultiple Airlines

Deal found 9/15

$373

Thu 10/305:00 amCMH - BOG

1 stop9h 15mSpirit Airlines

Thu 11/61:57 pmBOG - CMH

1 stop18h 18mSpirit Airlines

Deal found 9/15

$282

Fri 10/315:00 amCMH - BOG

1 stop9h 15mSpirit Airlines

Fri 11/73:05 pmBOG - CMH

1 stop30h 07mSpirit Airlines

Deal found 9/16

$317

Fri 10/316:21 pmCMH - CTG

2 stops19h 04mSpirit Airlines

Fri 11/72:16 pmCTG - CMH

1 stop6h 56mSpirit Airlines

Deal found 9/15

$379

One-way flights from Columbus to South America
Search for one-way flight options from Columbus to South America. Find affordable one-way fares based on user searches. Data last updated September 17, 2025.

Sun 10/195:00 amCMH - CTG

1 stop8h 25mSpirit Airlines

Deal found 9/15

$119

Thu 11/136:45 amCMH - MDE

1 stop11h 19mSpirit Airlines

Deal found 9/17

$134

Sun 10/192:36 pmCMH - CTG

2 stops22h 49mMultiple Airlines

Deal found 9/15

$146

Sun 9/285:15 amCMH - MDE

1 stop8h 59mSpirit Airlines

Deal found 9/15

$169

Wed 9/245:15 amCMH - BOG

1 stop8h 55mSpirit Airlines

Deal found 9/15

$172

Mon 10/2012:28 pmCMH - CTG

3 stops24h 20mMultiple Airlines

Deal found 9/15

$175

Thu 9/255:15 amCMH - BOG

1 stop8h 55mSpirit Airlines

Deal found 9/16

$187

Sun 9/287:16 pmCMH - MDE

2 stops21h 59mMultiple Airlines

Deal found 9/15

$198

Wed 9/247:16 pmCMH - BOG

1 stop22h 24mMultiple Airlines

Deal found 9/15

$198

Tue 9/238:34 amCMH - BOG

2 stops12h 33mMultiple Airlines

Deal found 9/15

$213

Thu 9/2512:31 pmCMH - BOG

2 stops11h 24mMultiple Airlines

Deal found 9/16

$220

Wed 10/158:42 amCMH - CTG

3 stops23h 13mMultiple Airlines

Deal found 9/15

$225

Cheapflights Fare Finder

Use the filters below to find and compare flights from Columbus Airport to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbusMedellín

CMH - MDE

CMHMDE

Columbus

Thu 10/9

5:00 am-1:11 pm

1 stop9h 11m

Medellín Jose Maria Cordova Intl

Fri 10/24

1:16 am-11:58 am

1 stop9h 42m

$291

ColumbusMedellín

CMH - MDE

CMHMDE

Columbus

Thu 10/9

5:00 am-1:11 pm

1 stop9h 11m

Medellín Jose Maria Cordova Intl

Wed 10/29

1:16 am-11:58 am

1 stop9h 42m

$291

ColumbusBogotá

CMH - BOG

CMHBOG

Columbus

Fri 10/31

5:00 am-1:15 pm

1 stop9h 15m

Bogotá El Dorado

Fri 11/7

3:05 pm-9:12 pm

1 stop30h 07m

$317

ColumbusMedellín

CMH - MDE

CMHMDE

Columbus

Thu 10/23

5:00 am-12:21 am

1 stop20h 21m

Medellín Jose Maria Cordova Intl

Sat 10/25

1:16 am-11:58 am

1 stop9h 42m

$335

ColumbusBogotá

CMH - BOG

CMHBOG

Columbus

Thu 10/30

5:00 am-1:15 pm

1 stop9h 15m

Bogotá El Dorado

Thu 11/6

3:05 pm-7:41 am

2 stops16h 36m

$339

ColumbusCartagena

CMH - CTG

CMHCTG

Columbus

Sun 11/9

5:22 pm-1:08 pm

2 stops19h 46m

Cartagena Rafael Nunez

Thu 11/13

2:16 pm-9:12 pm

1 stop6h 56m

$344

ColumbusBogotá

CMH - BOG

CMHBOG

Columbus

Tue 9/30

5:15 am-7:16 am

3 stops27h 01m

Bogotá El Dorado

Wed 10/15

4:25 pm-11:58 am

2 stops18h 33m

$364

ColumbusMedellín

CMH - MDE

CMHMDE

Columbus

Thu 11/13

6:45 am-6:04 pm

1 stop11h 19m

Medellín Jose Maria Cordova Intl

Fri 11/21

3:11 pm-9:55 am

1 stop18h 44m

$371

ColumbusMedellín

CMH - MDE

CMHMDE

Columbus

Thu 10/23

5:00 am-6:50 pm

1 stop14h 50m

Medellín Jose Maria Cordova Intl

Sun 10/26

1:00 pm-11:58 am

1 stop21h 58m

$373

ColumbusBogotá

CMH - BOG

CMHBOG

Columbus

Wed 9/24

5:15 am-1:10 pm

1 stop8h 55m

Bogotá El Dorado

Sat 10/11

2:10 pm-11:58 am

1 stop20h 48m

$374

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 54 results

...

Best time to book a flight from Columbus to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Columbus with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbus Airport to South America

What is the cheapest month to book a flight from Columbus Airport to South America?

Currently, May is the cheapest month in which you can book a flight from Columbus Airport to South America (average of $359). Flying from Columbus Airport to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CMH to SA?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Columbus Airport to South America as you normally would.

Reviews of airlines servicing South America

Get a feel of what it's like to fly with Delta, LATAM Airlines, and United Airlines from Columbus Airport to South America by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,961 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,961 reviews

Delta

8.0

Very good

7,961 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

LATAM Airlines

7.5

Good

1,849 reviews

Delta

8.0

Very good

7,961 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,926 reviews

Delta

8.0

Very good

7,961 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,961 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Spirit Airlines

6.3

Okay

8,023 reviews

Delta

8.0

Very good

7,961 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

How long is the flight from Columbus Airport to South America?
Spirit Airlines and United Airlines can get you from Columbus Airport to South America in just under 9h 11m. Your travel time can differ by up to 21h 53m. Airlines will cover a distance of 2382 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the most popular routes from Columbus Airport to South America?
When deciding which route to take from Columbus Airport to South America consider Columbus - Medellín Jose Maria Cordova Intl, Columbus - Cartagena Rafael Nunez or Columbus - Buenos Aires Ministro Pistarini as they are the most popular.
Can I find deals for flights from Columbus to South America that include hotel bookings?
Yes. In addition to deals on Columbus to South America flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Columbus to South America?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbus to South America.
Can I find deals for business class flights from Columbus to South America?
Yes. Cheapflights offers flight deals from Columbus to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Columbus Airport to South America?
Currently, May is the cheapest month in which you can book a flight from Columbus Airport to South America (average of $359). Flying from Columbus Airport to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 6 airlines flying from Columbus to South America

Airline	Cheapest	Average	Flexibility	On-time
Spirit Airlines	Cheapest$261	Average$431	FlexibilityNo cancel fee	On-time65%
LATAM Airlines	Cheapest$370	Average$871	FlexibilityNo cancel fee	On-time81%
American Airlines	Cheapest$423	Average$774	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$534	Average$926	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$539	Average$937	FlexibilityNo cancel fee	On-timeN/A
Air Canada	Cheapest$744	Average$956	FlexibilityNo cancel fee	On-time67%

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$119+ Cheap flights from Columbus (CMH) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/20. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Columbus to South America with Cheapflights

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2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Columbus to South America

Keep the following information in mind while searching for Columbus to South America flight deals. Data was last updated September 17, 2025.

Round-trip from

One-way from

Find flight deals from Columbus to South America

Cheapest flights from Columbus to South AmericaExplore the most affordable flight options available from Columbus to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

Explore the most affordable flight options available from Columbus to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Columbus Airport to South America that are best for you.

Best time to book a flight from Columbus to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Columbus with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Columbus Airport to South America

What is the cheapest month to book a flight from Columbus Airport to South America?

What is the cheapest time of day to fly from CMH to SA?

Find hourly flight availability from Columbus to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

Reviews of airlines servicing South America

Get a feel of what it's like to fly with Delta, LATAM Airlines, and United Airlines from Columbus Airport to South America by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Columbus to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Columbus Airport to South America?

What are the most popular routes from Columbus Airport to South America?

Can I find deals for flights from Columbus to South America that include hotel bookings?

How can I find direct flights from Columbus to South America?

Can I find deals for business class flights from Columbus to South America?

What is the cheapest month to book a flight from Columbus Airport to South America?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Columbus to South America

See prices for flight routes from nearby airports that may be better suited for you.

Top 6 airlines flying from Columbus to South America

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Travel Smart

Cheapest flights from Columbus to South America
Explore the most affordable flight options available from Columbus to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.