How long is the flight from Columbus Airport to South America?

Spirit Airlines can get you from Columbus Airport to South America in just under 7h 49m. Your travel time can differ by up to . Airlines will cover a distance of 2382 mi.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

What are the most popular routes from Columbus Airport to South America?

When deciding which route to take from Columbus Airport to South America consider Columbus - Buenos Aires Ministro Pistarini, Columbus - Medellín Jose Maria Cordova Intl or Columbus - Buenos Aires Jorge Newbery as they are the most popular.

What are the most popular airlines that fly from Columbus Airport to South America?

When booking a flight from Columbus Airport to South America, you may want to consider flying on Delta, American Airlines or Spirit Airlines as they are the most popular for this route.

Can I find deals for flights from Columbus to South America that include hotel bookings?

Yes. In addition to deals on Columbus to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Columbus to South America?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbus to South America.

Can I find deals for business class flights from Columbus to South America?

Yes. Cheapflights offers flight deals from Columbus to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$103+ Flights from Columbus Airport to South America

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

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Cheap flight deals from Columbus to South America

Cheapest flights from Columbus to South America
Explore the most affordable flight options available from Columbus to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 23, 2025.

Wed 12/316:28 pmCMH - GYE

2 stops29h 25mSpirit Airlines

Fri 1/161:26 amGYE - CMH

1 stop22h 01mSpirit Airlines

Deal found 12/21

$528

Mon 12/298:02 pmCMH - GYE

2 stops51h 51mMultiple Airlines

Fri 1/161:26 amGYE - CMH

1 stop22h 01mMultiple Airlines

Deal found 12/21

$529

Tue 12/239:13 pmCMH - GYE

2 stops38h 05mMultiple Airlines

Fri 1/161:26 amGYE - CMH

1 stop22h 01mMultiple Airlines

Deal found 12/21

$551

Tue 12/309:13 pmCMH - GYE

2 stops26h 40mMultiple Airlines

Fri 1/161:26 amGYE - CMH

1 stop22h 01mMultiple Airlines

Deal found 12/21

$565

Wed 12/316:28 pmCMH - GYE

2 stops29h 25mSpirit Airlines

Mon 1/121:26 amGYE - CMH

1 stop22h 01mSpirit Airlines

Deal found 12/21

$602

Sun 12/289:13 pmCMH - GYE

2 stops26h 22mMultiple Airlines

Fri 1/161:26 amGYE - CMH

1 stop22h 01mMultiple Airlines

Deal found 12/21

$605

Mon 12/298:02 pmCMH - GYE

2 stops27h 51mMultiple Airlines

Mon 1/121:26 amGYE - CMH

1 stop22h 01mMultiple Airlines

Deal found 12/21

$613

Tue 12/239:13 pmCMH - GYE

2 stops38h 05mMultiple Airlines

Wed 1/141:26 amGYE - CMH

1 stop22h 01mMultiple Airlines

Deal found 12/21

$630

Tue 12/309:13 pmCMH - GYE

2 stops23h 12mMultiple Airlines

Mon 1/121:26 amGYE - CMH

1 stop22h 01mMultiple Airlines

Deal found 12/21

$639

Thu 12/256:28 pmCMH - GYE

2 stops30h 37mMultiple Airlines

Fri 1/161:26 amGYE - CMH

1 stop22h 01mMultiple Airlines

Deal found 12/21

$667

Wed 12/248:23 amCMH - BOG

2 stops15h 07mGOL

Thu 12/2511:55 pmBOG - CMH

1 stop18h 43mGOL

Deal found 12/22

$716

Tue 12/239:13 pmCMH - MDE

2 stops35h 05mMultiple Airlines

Thu 12/252:54 pmMDE - CMH

1 stop9h 03mMultiple Airlines

Deal found 12/20

$747

Best flights from Columbus to South America
Discover carefully curated flight deals from Columbus to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 23, 2025.

Tue 1/206:06 amCMH - MDE

1 stop7h 49mSpirit Airlines

Thu 1/292:50 pmMDE - CMH

1 stop8h 29mSpirit Airlines

Deal found 12/22

$284

Tue 1/135:45 amCMH - GYE

1 stop18h 36mMultiple Airlines

Wed 1/146:50 pmGYE - CMH

2 stops16h 08mMultiple Airlines

Deal found 12/21

$330

Thu 2/511:12 amCMH - BOG

2 stops10h 58mAmerican Airlines

Thu 2/128:00 amBOG - CMH

2 stops14h 25mAmerican Airlines

Deal found 12/22

$493

Wed 2/45:45 amCMH - BOG

1 stop8h 22mSpirit Airlines

Wed 2/111:45 pmBOG - CMH

1 stop9h 34mSpirit Airlines

Deal found 12/21

$292

Thu 2/55:45 amCMH - BOG

1 stop8h 22mSpirit Airlines

Thu 2/121:45 pmBOG - CMH

1 stop10h 08mSpirit Airlines

Deal found 12/22

$292

Tue 2/35:45 amCMH - BOG

1 stop8h 22mMultiple Airlines

Tue 2/39:48 pmBOG - CMH

2 stops25h 31mMultiple Airlines

Deal found 12/21

$354

Wed 2/256:15 amCMH - MDE

1 stop7h 58mSpirit Airlines

Tue 3/33:15 pmMDE - CMH

1 stop8h 17mSpirit Airlines

Deal found 12/21

$295

Mon 3/236:24 pmCMH - SCL

2 stops18h 41mLATAM Airlines

Tue 4/1410:55 pmSCL - CMH

1 stop18h 49mLATAM Airlines

Deal found 12/21

$779

Wed 2/186:15 amCMH - MDE

1 stop7h 58mSpirit Airlines

Wed 2/253:15 pmMDE - CMH

1 stop8h 17mSpirit Airlines

Deal found 12/21

$295

Tue 1/206:06 amCMH - MDE

1 stop7h 49mMultiple Airlines

Thu 1/2910:00 pmMDE - CMH

2 stops36h 29mMultiple Airlines

Deal found 12/22

$359

Mon 1/1210:40 amCMH - GYE

1 stop13h 41mMultiple Airlines

Tue 1/137:05 pmGYE - CMH

2 stops39h 53mMultiple Airlines

Deal found 12/21

$359

Tue 3/39:30 amCMH - GRU

2 stops29h 40mAir Canada

Sun 3/82:10 pmGRU - CMH

2 stops31h 46mAir Canada

Deal found 12/22

$911

Fri 2/205:45 amCMH - MDE

1 stop8h 10mSpirit Airlines

Thu 2/263:15 pmMDE - CMH

1 stop8h 17mSpirit Airlines

Deal found 12/21

$337

Wed 2/256:15 amCMH - MDE

2 stops13h 05mMultiple Airlines

Tue 3/33:15 pmMDE - CMH

1 stop8h 17mMultiple Airlines

Deal found 12/21

$377

Wed 4/16:20 amCMH - GIG

1 stop24h 55mUnited Airlines

Wed 4/89:05 pmGIG - CMH

1 stop14h 52mUnited Airlines

Deal found 12/21

$1,050

Sun 3/85:30 amCMH - GIG

2 stops25h 30mCopa Airlines

Sun 3/2210:10 amGIG - CMH

2 stops24h 28mCopa Airlines

Deal found 12/21

$1,089

Sat 1/315:45 amCMH - BOG

1 stop8h 22mSpirit Airlines

Sun 2/83:06 pmBOG - CMH

1 stop18h 34mSpirit Airlines

Deal found 12/22

$340

Sat 1/249:25 amCMH - MDE

1 stop28h 30mMultiple Airlines

Sat 2/710:45 pmMDE - CMH

2 stops34h 55mMultiple Airlines

Deal found 12/22

$397

Wed 1/146:06 amCMH - GYE

2 stops18h 15mSpirit Airlines

Fri 1/161:26 amGYE - CMH

1 stop22h 01mSpirit Airlines

Deal found 12/21

$341

Sun 1/1110:40 amCMH - GYE

1 stop13h 41mMultiple Airlines

Wed 1/146:50 pmGYE - CMH

2 stops16h 08mMultiple Airlines

Deal found 12/21

$411

Wed 1/215:45 amCMH - LIM

1 stop16h 50mSpirit Airlines

Wed 1/2811:33 pmLIM - CMH

2 stops23h 46mSpirit Airlines

Deal found 12/23

$360

Sun 2/2211:39 amCMH - LIM

1 stop10h 56mSpirit Airlines

Wed 2/2511:30 pmLIM - CMH

1 stop11h 14mSpirit Airlines

Deal found 12/21

$365

Wed 5/1312:05 pmCMH - SCL

1 stop18h 45mLATAM Airlines

Wed 5/208:40 pmSCL - CMH

1 stop14h 56mLATAM Airlines

Deal found 12/21

$787

Thu 2/196:15 amCMH - GYE

1 stop17h 49mSpirit Airlines

Thu 2/2612:59 amGYE - CMH

1 stop9h 45mSpirit Airlines

Deal found 12/22

$366

Mon 6/112:05 pmCMH - SCL

1 stop18h 45mLATAM Airlines

Mon 6/2211:05 pmSCL - CMH

2 stops19h 44mLATAM Airlines

Deal found 12/20

$787

Wed 4/810:41 amCMH - BOG

1 stop10h 09mMultiple Airlines

Tue 4/1411:00 pmBOG - CMH

1 stop9h 45mMultiple Airlines

Deal found 12/22

$497

Sun 3/89:30 amCMH - GRU

2 stops22h 30mAir Canada

Wed 3/119:30 pmGRU - CMH

1 stop24h 26mAir Canada

Deal found 12/20

$942

Wed 1/215:45 amCMH - LIM

1 stop16h 50mSpirit Airlines

Tue 1/2711:33 pmLIM - CMH

1 stop23h 54mSpirit Airlines

Deal found 12/23

$368

Fri 2/66:34 pmCMH - SCL

2 stops21h 21mLATAM Airlines

Tue 2/1011:10 pmSCL - CMH

1 stop12h 45mLATAM Airlines

Deal found 12/20

$804

Tue 1/275:45 amCMH - BOG

3 stops28h 55mMultiple Airlines

Sun 2/151:45 pmBOG - CMH

1 stop10h 08mMultiple Airlines

Deal found 12/20

$502

Last-minute flights from Columbus to South America
Discover last-minute flight deals from Columbus to South America. Data last updated December 23, 2025 and is based on user searches.

Mon 1/1210:40 amCMH - GYE

1 stop13h 41mSpirit Airlines

Fri 1/161:26 amGYE - CMH

1 stop22h 01mSpirit Airlines

Deal found 12/21

$346

Mon 1/1210:40 amCMH - GYE

1 stop13h 41mMultiple Airlines

Tue 1/137:05 pmGYE - CMH

2 stops39h 53mMultiple Airlines

Deal found 12/21

$359

Tue 1/135:45 amCMH - GYE

1 stop18h 36mSpirit Airlines

Fri 1/161:26 amGYE - CMH

1 stop22h 01mSpirit Airlines

Deal found 12/21

$313

Tue 1/135:45 amCMH - GYE

1 stop18h 36mMultiple Airlines

Wed 1/146:50 pmGYE - CMH

2 stops16h 08mMultiple Airlines

Deal found 12/21

$330

Wed 1/145:45 amCMH - GYE

1 stop18h 36mSpirit Airlines

Fri 1/161:26 amGYE - CMH

1 stop22h 01mSpirit Airlines

Deal found 12/21

$358

Thu 1/155:45 amCMH - GYE

1 stop18h 36mSpirit Airlines

Fri 1/161:26 amGYE - CMH

1 stop22h 01mSpirit Airlines

Deal found 12/21

$336

Thu 1/1512:00 pmCMH - GYE

2 stops12h 21mMultiple Airlines

Fri 1/161:26 amGYE - CMH

1 stop22h 01mMultiple Airlines

Deal found 12/21

$342

Tue 1/206:06 amCMH - MDE

1 stop7h 49mSpirit Airlines

Thu 1/292:50 pmMDE - CMH

1 stop8h 29mSpirit Airlines

Deal found 12/22

$284

Tue 1/206:06 amCMH - MDE

1 stop7h 49mMultiple Airlines

Thu 1/2910:00 pmMDE - CMH

2 stops36h 29mMultiple Airlines

Deal found 12/22

$359

Wed 1/215:45 amCMH - LIM

1 stop16h 50mSpirit Airlines

Wed 1/2811:33 pmLIM - CMH

1 stop10h 07mSpirit Airlines

Deal found 12/23

$318

Sat 1/316:06 amCMH - MDE

1 stop7h 49mSpirit Airlines

Thu 2/53:15 pmMDE - CMH

1 stop8h 12mSpirit Airlines

Deal found 12/21

$280

Sat 1/316:06 amCMH - BOG

2 stops32h 01mSpirit Airlines

Sun 2/83:06 pmBOG - CMH

1 stop18h 34mSpirit Airlines

Deal found 12/22

$334

One-way flights from Columbus to South America
Search for one-way flight options from Columbus to South America. Find affordable one-way fares based on user searches. Data last updated December 23, 2025.

Tue 2/35:45 amCMH - BOG

1 stop8h 22mSpirit Airlines

Deal found 12/22

$103

Fri 2/2711:17 amCMH - BOG

2 stops26h 53mMultiple Airlines

Deal found 12/22

$119

Fri 2/276:15 amCMH - BOG

1 stop7h 55mSpirit Airlines

Deal found 12/22

$124

Wed 2/46:06 amCMH - MDE

1 stop7h 49mSpirit Airlines

Deal found 12/22

$130

Tue 1/206:06 amCMH - BOG

2 stops22h 59mMultiple Airlines

Deal found 12/21

$145

Tue 1/205:45 amCMH - BOG

1 stop8h 22mSpirit Airlines

Deal found 12/21

$147

Wed 2/45:45 amCMH - BOG

1 stop8h 22mSpirit Airlines

Deal found 12/22

$150

Tue 2/35:45 amCMH - BOG

3 stops32h 20mMultiple Airlines

Deal found 12/22

$158

Mon 1/196:06 amCMH - BOG

1 stop30h 44mSpirit Airlines

Deal found 12/20

$159

Wed 2/45:45 amCMH - MDE

3 stops24h 20mMultiple Airlines

Deal found 12/22

$165

Tue 1/136:06 amCMH - BOG

2 stops23h 39mMultiple Airlines

Deal found 12/22

$171

Mon 1/196:06 amCMH - BOG

2 stops21h 03mMultiple Airlines

Deal found 12/20

$189

Find flight deals from Columbus to South America

Round-trip from	$280 (Cheapflightsfares)
One-way from	$103 (Cheapflightsfares)

From Columbus to South America

Search Deals

One-way flight from Columbus to South America

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Columbus Airport to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbusMedellín

CMH - MDE

CMHMDE

Columbus

Tue 1/20

6:06 am-1:55 pm

1 stop7h 49m

Medellín Jose Maria Cordova Intl

Thu 1/29

2:50 pm-11:19 pm

1 stop8h 29m

$284

ColumbusBogotá

CMH - BOG

CMHBOG

Columbus

Wed 2/4

5:45 am-2:07 pm

1 stop8h 22m

Bogotá El Dorado

Wed 2/11

1:45 pm-11:19 pm

1 stop9h 34m

$292

ColumbusBogotá

CMH - BOG

CMHBOG

Columbus

Thu 2/5

5:45 am-2:07 pm

1 stop8h 22m

Bogotá El Dorado

Thu 2/12

1:45 pm-11:53 pm

1 stop10h 08m

$292

ColumbusMedellín

CMH - MDE

CMHMDE

Columbus

Wed 2/25

6:15 am-2:13 pm

1 stop7h 58m

Medellín Jose Maria Cordova Intl

Tue 3/3

3:15 pm-11:32 pm

1 stop8h 17m

$295

ColumbusMedellín

CMH - MDE

CMHMDE

Columbus

Wed 2/18

6:15 am-2:13 pm

1 stop7h 58m

Medellín Jose Maria Cordova Intl

Wed 2/25

3:15 pm-11:32 pm

1 stop8h 17m

$295

ColumbusGuayaquil

CMH - GYE

CMHGYE

Columbus

Tue 1/13

5:45 am-12:21 am

1 stop18h 36m

Guayaquil Jose Joaquin de Olmedo

Wed 1/14

6:50 pm-10:58 am

2 stops16h 08m

$330

ColumbusMedellín

CMH - MDE

CMHMDE

Columbus

Fri 2/20

5:45 am-1:55 pm

1 stop8h 10m

Medellín Jose Maria Cordova Intl

Thu 2/26

3:15 pm-11:32 pm

1 stop8h 17m

$337

ColumbusBogotá

CMH - BOG

CMHBOG

Columbus

Sat 1/31

5:45 am-2:07 pm

1 stop8h 22m

Bogotá El Dorado

Sun 2/8

3:06 pm-9:40 am

1 stop18h 34m

$340

ColumbusGuayaquil

CMH - GYE

CMHGYE

Columbus

Wed 1/14

6:06 am-12:21 am

2 stops18h 15m

Guayaquil Jose Joaquin de Olmedo

Fri 1/16

1:26 am-11:27 pm

1 stop22h 01m

$341

ColumbusBogotá

CMH - BOG

CMHBOG

Columbus

Tue 2/3

5:45 am-2:07 pm

1 stop8h 22m

Bogotá El Dorado

Tue 2/3

9:48 pm-11:19 pm

2 stops25h 31m

$354

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/22

Showing 1-10 of 52 results

...

Best time to book a flight from Columbus to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Columbus with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbus Airport to South America

What is the cheapest month to book a flight from Columbus Airport to South America?

Currently, March is the cheapest month in which you can book a flight from Columbus Airport to South America (average of $277). Flying from Columbus Airport to South America in June is currently the most expensive (average of $461). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CMH to SA?

It’s typically best to fly out from Columbus Airport to South America at noon. Doing so could potentially save you 11% on the flight price compared to flying in the morning, which is usually more expensive.

What is the cheapest day to fly from Columbus Airport to South America?

Travelers seeking maximum savings on their Columbus Airport to South America flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Friday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South America

Get a feel of what it's like to fly with Delta, LATAM Airlines, and American Airlines from Columbus Airport to South America by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

8,014 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Delta

7.9

Good

8,014 reviews

Delta

7.9

Good

8,014 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

LATAM Airlines

7.5

Good

1,894 reviews

Delta

7.9

Good

8,014 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

American Airlines

7.2

Good

11,050 reviews

Delta

7.9

Good

8,014 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

Air Canada

7.1

Good

10,551 reviews

Delta

7.9

Good

8,014 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

Spirit Airlines

6.3

Okay

8,194 reviews

Delta

7.9

Good

8,014 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

Related info for your journey

How long is the flight from Columbus Airport to South America?
Spirit Airlines can get you from Columbus Airport to South America in just under 7h 49m. Your travel time can differ by up to . Airlines will cover a distance of 2382 mi.
What are the most popular routes from Columbus Airport to South America?
When deciding which route to take from Columbus Airport to South America consider Columbus - Buenos Aires Ministro Pistarini, Columbus - Medellín Jose Maria Cordova Intl or Columbus - Buenos Aires Jorge Newbery as they are the most popular.
Can I find deals for flights from Columbus to South America that include hotel bookings?
Yes. In addition to deals on Columbus to South America flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Columbus to South America?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbus to South America.
Can I find deals for business class flights from Columbus to South America?
Yes. Cheapflights offers flight deals from Columbus to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Columbus Airport to South America?
Currently, March is the cheapest month in which you can book a flight from Columbus Airport to South America (average of $277). Flying from Columbus Airport to South America in June is currently the most expensive (average of $461). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 6 airlines flying from Columbus to South America

Airline	Cheapest	Average	Flexibility	On-time
Spirit Airlines	Cheapest$276	Average$406	FlexibilityNo cancel fee	On-time65%
American Airlines	Cheapest$490	Average$799	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$534	Average$613	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$552	Average$860	FlexibilityNo cancel fee	On-timeN/A
LATAM Airlines	Cheapest$555	Average$820	FlexibilityNo cancel fee	On-time81%
Air Canada	Cheapest$744	Average$956	FlexibilityNo cancel fee	On-time67%

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$103+ Cheap flights from Columbus (CMH) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/3. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Columbus to South America with Cheapflights

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Cheap flight deals from Columbus to South America

Cheapest flights from Columbus to South AmericaExplore the most affordable flight options available from Columbus to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 23, 2025.

Explore the most affordable flight options available from Columbus to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 23, 2025.

Find flight deals from Columbus to South America

Keep the following information in mind while searching for Columbus to South America flight deals. Data was last updated December 23, 2025.

Round-trip from

One-way from

Cheapflights Fare Finder

Use the filters below to find and compare flights from Columbus Airport to South America that are best for you.

Best time to book a flight from Columbus to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Columbus with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Columbus Airport to South America

What is the cheapest month to book a flight from Columbus Airport to South America?

What is the cheapest time of day to fly from CMH to SA?

Find hourly flight availability from Columbus to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 23, 2025.

What is the cheapest day to fly from Columbus Airport to South America?

Use this chart to determine the cheapest time to fly round-trip from Columbus to South America. Price data was last updated on December 16, 2024.

Reviews of airlines servicing South America

Get a feel of what it's like to fly with Delta, LATAM Airlines, and American Airlines from Columbus Airport to South America by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Columbus to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Columbus Airport to South America?

What are the most popular routes from Columbus Airport to South America?

Can I find deals for flights from Columbus to South America that include hotel bookings?

How can I find direct flights from Columbus to South America?

Can I find deals for business class flights from Columbus to South America?

What is the cheapest month to book a flight from Columbus Airport to South America?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Columbus to South America

See prices for flight routes from nearby airports that may be better suited for you.

Top 6 airlines flying from Columbus to South America

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Cheapest flights from Columbus to South America
Explore the most affordable flight options available from Columbus to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 23, 2025.