South America

$175+ Cheap flights from Myrtle Beach (MYR) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/16. Fares are subject to change and may not be available on all flights or dates of travel.
MYR — BOG
May 27 — Jun 31
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Myrtle Beach to South America with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Myrtle Beach to South America

Cheapest flights from Myrtle Beach to South America
Explore the most affordable flight options available from Myrtle Beach to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 27, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/76:00 am
MYR
-
GYE
1 stop18h 04m
Spirit Airlines
Sun 6/1411:59 pm
GYE
-
MYR
2 stops13h 49m
Spirit Airlines
Deal found 4/23$477
This Mytrip deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/106:00 am
MYR
-
GYE
2 stops27h 55m
Multiple Airlines
Sat 5/233:30 am
GYE
-
MYR
2 stops16h 06m
Multiple Airlines
Deal found 4/24$518
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/76:00 am
MYR
-
GYE
1 stop18h 04m
Multiple Airlines
Sun 6/1411:59 pm
GYE
-
MYR
1 stop13h 21m
Multiple Airlines
Deal found 4/23$524
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/183:43 pm
MYR
-
MDE
1 stop22h 42m
Spirit Airlines
Fri 7/312:26 pm
MDE
-
MYR
1 stop28h 45m
Spirit Airlines
Deal found 4/26$544
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/183:43 pm
MYR
-
MDE
1 stop22h 42m
Multiple Airlines
Fri 7/316:00 am
MDE
-
MYR
2 stops36h 37m
Multiple Airlines
Deal found 4/26$584
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/103:53 pm
MYR
-
CTG
2 stops32h 07m
Multiple Airlines
Fri 5/151:31 pm
CTG
-
MYR
1 stop29h 06m
Multiple Airlines
Deal found 4/24$589
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/273:17 pm
MYR
-
BOG
2 stops30h 08m
Multiple Airlines
Tue 7/212:07 pm
BOG
-
MYR
1 stop29h 00m
Multiple Airlines
Deal found 4/22$591
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:50 am
MYR
-
BOG
2 stops15h 27m
American Airlines
Tue 7/212:10 pm
BOG
-
MYR
2 stops19h 44m
American Airlines
Deal found 4/22$605
This American Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/188:12 am
MYR
-
MDE
2 stops13h 04m
American Airlines
Fri 7/316:00 am
MDE
-
MYR
2 stops15h 20m
American Airlines
Deal found 4/26$608
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1310:55 am
MYR
-
BOG
2 stops27h 45m
Multiple Airlines
Tue 7/212:07 pm
BOG
-
MYR
1 stop29h 00m
Multiple Airlines
Deal found 4/22$624
This LATAM Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:00 am
MYR
-
BOG
1 stop8h 40m
LATAM Airlines
Tue 7/219:00 am
BOG
-
MYR
1 stop9h 07m
LATAM Airlines
Deal found 4/22$633
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:50 am
MYR
-
UIO
2 stops18h 08m
American Airlines
Tue 6/3011:59 pm
UIO
-
MYR
2 stops20h 48m
American Airlines
Deal found 4/23$642

Find flight deals from Myrtle Beach to South America

Keep the following information in mind while searching for Myrtle Beach to South America flight deals. Data was last updated April 27, 2026.

Round-trip from

$477
(Kiwi.com)

One-way from

$175
(Mytrip)
From Myrtle Beach Intl to South America
One-way flight from Myrtle Beach Intl to South America

Cheapflights Fare Finder

 
Customize your flight search to find flights from Myrtle Beach to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 27, 2026.
Use the filters below to find and compare flights from Myrtle Beach to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Myrtle BeachGuayaquil

MYR - GYE

MYRGYE

Myrtle Beach Intl

Sun 6/7

6:00 am-11:04 pm

1 stop18h 04m

Guayaquil Jose Joaquin de Olmedo

Sun 6/14

11:59 pm-2:48 pm

2 stops13h 49m

$477

Myrtle BeachGuayaquil

MYR - GYE

MYRGYE

Myrtle Beach Intl

Sun 6/7

6:00 am-11:04 pm

1 stop18h 04m

Guayaquil Jose Joaquin de Olmedo

Sun 6/14

11:59 pm-2:20 pm

1 stop13h 21m

$524

Myrtle BeachMedellín

MYR - MDE

MYRMDE

Myrtle Beach Intl

Sat 7/18

3:43 pm-1:25 pm

1 stop22h 42m

Medellín Jose Maria Cordova Intl

Fri 7/31

2:26 pm-8:11 pm

1 stop28h 45m

$544

Myrtle BeachMedellín

MYR - MDE

MYRMDE

Myrtle Beach Intl

Sat 7/18

3:43 pm-1:25 pm

1 stop22h 42m

Medellín Jose Maria Cordova Intl

Fri 7/31

6:00 am-7:37 pm

2 stops36h 37m

$584

Myrtle BeachCartagena

MYR - CTG

MYRCTG

Myrtle Beach Intl

Sun 5/10

3:53 pm-11:00 pm

2 stops32h 07m

Cartagena Rafael Nunez

Fri 5/15

1:31 pm-7:37 pm

1 stop29h 06m

$589

Myrtle BeachGuayaquil

MYR - GYE

MYRGYE

Myrtle Beach Intl

Sun 5/10

6:00 am-11:04 pm

1 stop18h 04m

Guayaquil Jose Joaquin de Olmedo

Sun 5/24

11:59 pm-2:20 pm

1 stop13h 21m

$638

Myrtle BeachQuito

MYR - UIO

MYRUIO

Myrtle Beach Intl

Tue 6/9

6:50 am-11:58 pm

2 stops18h 08m

Quito Mariscal Sucr

Tue 6/30

11:59 pm-9:47 pm

2 stops20h 48m

$642

Myrtle BeachLima

MYR - LIM

MYRLIM

Myrtle Beach Intl

Tue 9/1

6:00 am-9:35 pm

2 stops16h 35m

Lima J Chavez Intl

Wed 9/9

8:55 am-10:09 am

2 stops24h 14m

$665

Myrtle BeachLima

MYR - LIM

MYRLIM

Myrtle Beach Intl

Tue 9/1

6:00 am-9:35 pm

2 stops16h 35m

Lima J Chavez Intl

Wed 9/9

12:05 pm-11:39 pm

1 stop10h 34m

$665

Myrtle BeachLima

MYR - LIM

MYRLIM

Myrtle Beach Intl

Thu 8/27

6:00 am-8:20 pm

2 stops15h 20m

Lima J Chavez Intl

Sun 9/27

8:55 am-11:39 pm

2 stops13h 44m

$695

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/25

Showing 1-10 of 50 resultsSorted by cheapest first
1
2
3
...
5

Best time to book a flight from Myrtle Beach to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Myrtle Beach with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Myrtle Beach to South America
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated April 27, 2026.
Peruse reviews from past customers who have flown with Delta and LATAM Airlines from Myrtle Beach to South America to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Food

7.2

Crew

8.5

Entertainment

7.8

Comfort

7.9

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Food

7.2

Crew

8.5

Entertainment

7.8

Comfort

7.9

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Food

7.2

Crew

8.5

Entertainment

7.8

Comfort

7.9

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Myrtle Beach to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from Myrtle Beach to South America?

    Myrtle Beach Intl (MYR), located 2.1 mi from the city center, is the airport you fly out of when you book flights from Myrtle Beach to South America.

  • How long is the flight from Myrtle Beach to South America?

    Spirit Airlines, American Airlines, and LATAM Airlines can get you from Myrtle Beach to South America in just under 16h 35m. Your travel time can differ by up to 1h 33m. There are 3158 mi between Myrtle Beach and South America. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Myrtle Beach to South America?

  • Can I find deals for flights from Myrtle Beach to South America that include hotel bookings?

    Yes. In addition to deals on Myrtle Beach to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Myrtle Beach to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Myrtle Beach to South America.

  • Can I find deals for business class flights from Myrtle Beach to South America?

    Yes. Cheapflights offers flight deals from Myrtle Beach to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Myrtle Beach to South America

See prices for flight routes from nearby airports that may be better suited for you.

Top airline flying from Myrtle Beach to South America

Discover the top airline that operate flights from Myrtle Beach to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$618Average$704FlexibilityNo cancel feeOn-time81%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.