$168+ Cheap flights from Missouri to South America
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/1. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BOG
Jun 5 — Jun 121
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Missouri to South America with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to South America
Cheapest
Best
Last-minute
One-way
Cheapest flights from Missouri to South AmericaExplore the most affordable flight options available from Missouri to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 6, 2026.
Explore the most affordable flight options available from Missouri to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 6, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/216:31 pm
STL
- BOG
2 stops26h 04m
Multiple Airlines
Tue 6/3010:35 am
BOG
- STL
1 stop13h 14m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$547
This Avianca deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:30 pm
STL
- BOG
1 stop9h 00m
Multiple Airlines
Tue 9/2212:05 am
BOG
- STL
1 stop13h 55m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$574
This Expedia deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/128:55 am
STL
- BOG
1 stop21h 00m
Multiple Airlines
Sat 10/314:15 pm
BOG
- STL
1 stop24h 15m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$593
This Booking.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:55 am
STL
- BOG
1 stop29h 10m
Multiple Airlines
Wed 9/234:15 pm
BOG
- STL
1 stop27h 45m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$594
This Expedia deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/84:15 pm
STL
- LIM
1 stop12h 55m
Air Canada
Fri 12/188:05 am
LIM
- STL
1 stop32h 25m
Air Canada
Deal found 5/3![Air Canada logo]()
$601
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/112:30 pm
STL
- BOG
1 stop9h 30m
United Airlines
Tue 9/227:20 am
BOG
- STL
1 stop16h 17m
United Airlines
Deal found 5/5![United Airlines logo]()
$616
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:54 am
STL
- BOG
2 stops14h 23m
American Airlines
Mon 9/212:35 pm
BOG
- STL
1 stop22h 47m
American Airlines
Deal found 5/5![American Airlines logo]()
$620
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:00 am
STL
- BOG
2 stops17h 00m
United Airlines
Wed 9/1612:14 am
BOG
- STL
1 stop17h 35m
United Airlines
Deal found 5/5![United Airlines logo]()
$621
This LATAM Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/226:00 am
STL
- BOG
2 stops12h 45m
LATAM Airlines
Fri 8/72:55 pm
BOG
- STL
1 stop8h 58m
LATAM Airlines
Deal found 5/2![LATAM Airlines logo]()
$625
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/215:29 pm
STL
- MDE
2 stops27h 41m
United Airlines
Tue 6/309:45 am
MDE
- STL
2 stops26h 26m
United Airlines
Deal found 5/2![United Airlines logo]()
$625
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/307:01 am
STL
- BOG
1 stop14h 59m
United Airlines
Wed 9/238:30 am
BOG
- STL
1 stop13h 46m
United Airlines
Deal found 5/5![United Airlines logo]()
$626
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:55 pm
MCI
- MDE
2 stops12h 50m
Multiple Airlines
Mon 10/124:50 am
MDE
- MCI
2 stops14h 41m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$635
Best flights from Missouri to South AmericaDiscover carefully curated flight deals from Missouri to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 6, 2026.
Discover carefully curated flight deals from Missouri to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 6, 2026.
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/217:12 pm
STL
- BOG
2 stops22h 38m
Delta
Thu 7/22:55 pm
BOG
- STL
1 stop9h 01m
Delta
Deal found 5/2![Delta logo]()
$621
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:00 am
STL
- BOG
2 stops16h 00m
United Airlines
Thu 9/248:30 am
BOG
- STL
2 stops24h 07m
United Airlines
Deal found 5/5![United Airlines logo]()
$621
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/2511:58 am
MCI
- BOG
1 stop9h 19m
American Airlines
Tue 8/46:30 am
BOG
- MCI
1 stop16h 26m
American Airlines
Deal found 5/2![American Airlines logo]()
$649
This KAYAK deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/255:34 pm
MCI
- BOG
2 stops26h 36m
LATAM Airlines
Tue 8/48:40 am
BOG
- MCI
2 stops15h 17m
LATAM Airlines
Deal found 5/3![LATAM Airlines logo]()
$654
This Copa Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:36 pm
MCI
- BOG
2 stops16h 30m
Copa Airlines
Tue 8/47:00 am
BOG
- MCI
2 stops25h 42m
Copa Airlines
Deal found 5/5![Copa Airlines logo]()
$657
This Expedia deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:05 am
STL
- MDE
2 stops26h 45m
Multiple Airlines
Wed 6/32:10 pm
MDE
- STL
2 stops21h 56m
Multiple Airlines
Deal found 5/1![Multiple Airlines logo]()
$668
This oojo deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1811:15 am
STL
- GRU
2 stops33h 50m
GOL
Thu 6/256:00 am
GRU
- STL
2 stops18h 57m
GOL
Deal found 5/4![GOL logo]()
$997
This Air Canada deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/32:15 pm
STL
- GRU
2 stops17h 35m
Air Canada
Sun 6/79:35 pm
GRU
- STL
1 stop16h 41m
Air Canada
Deal found 5/1![Air Canada logo]()
$1,126
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:30 pm
STL
- BOG
2 stops22h 15m
Delta
Mon 11/167:00 am
BOG
- STL
2 stops14h 49m
Delta
Deal found 5/3![Delta logo]()
$621
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/215:29 pm
STL
- MDE
2 stops27h 41m
United Airlines
Tue 6/309:45 am
MDE
- STL
2 stops26h 26m
United Airlines
Deal found 5/2![United Airlines logo]()
$625
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/255:00 am
STL
- MDE
1 stop7h 48m
American Airlines
Sat 8/2912:30 am
MDE
- STL
1 stop10h 15m
American Airlines
Deal found 5/4![American Airlines logo]()
$654
This Copa Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/246:41 pm
MCI
- BOG
2 stops22h 45m
Copa Airlines
Tue 8/411:39 am
BOG
- MCI
2 stops21h 03m
Copa Airlines
Deal found 5/5![Copa Airlines logo]()
$657
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/39:00 am
STL
- BOG
2 stops11h 35m
Delta
Thu 9/172:55 pm
BOG
- STL
1 stop8h 42m
Delta
Deal found 5/5![Delta logo]()
$627
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/297:30 am
STL
- BOG
2 stops14h 30m
United Airlines
Wed 9/238:30 am
BOG
- STL
2 stops12h 52m
United Airlines
Deal found 5/5![United Airlines logo]()
$631
This KAYAK deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/207:05 pm
STL
- LIM
2 stops26h 35m
LATAM Airlines
Mon 10/58:15 am
LIM
- STL
2 stops23h 57m
LATAM Airlines
Deal found 5/4![LATAM Airlines logo]()
$744
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/217:12 pm
STL
- BOG
2 stops22h 38m
Delta
Tue 6/308:40 am
BOG
- STL
2 stops15h 16m
Delta
Deal found 5/2![Delta logo]()
$633
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/46:00 am
STL
- BOG
1 stop16h 00m
United Airlines
Wed 6/1012:14 am
BOG
- STL
1 stop9h 53m
United Airlines
Deal found 5/5![United Airlines logo]()
$658
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/25:00 am
MCI
- MDE
1 stop15h 16m
American Airlines
Mon 7/66:00 am
MDE
- MCI
1 stop17h 59m
American Airlines
Deal found 5/3![American Airlines logo]()
$749
This KAYAK deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/147:12 pm
STL
- LIM
2 stops25h 08m
LATAM Airlines
Tue 6/238:55 am
LIM
- STL
2 stops15h 01m
LATAM Airlines
Deal found 5/2![LATAM Airlines logo]()
$765
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/305:23 pm
STL
- BOG
1 stop20h 17m
Delta
Fri 9/1810:35 am
BOG
- STL
2 stops13h 02m
Delta
Deal found 5/5![Delta logo]()
$636
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:22 am
MCI
- MDE
1 stop12h 48m
United Airlines
Tue 10/279:45 am
MDE
- MCI
2 stops12h 04m
United Airlines
Deal found 5/5![United Airlines logo]()
$659
This Copa Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/27:53 am
MCI
- LIM
2 stops31h 47m
Copa Airlines
Sat 7/182:15 am
LIM
- MCI
2 stops30h 27m
Copa Airlines
Deal found 5/3![Copa Airlines logo]()
$812
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:00 am
STL
- BOG
2 stops11h 50m
Delta
Mon 10/198:40 am
BOG
- STL
2 stops14h 59m
Delta
Deal found 5/4![Delta logo]()
$645
This KAYAK deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/166:00 am
STL
- LIM
2 stops15h 35m
LATAM Airlines
Fri 8/2112:10 am
LIM
- STL
2 stops23h 27m
LATAM Airlines
Deal found 5/2![LATAM Airlines logo]()
$799
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/136:00 am
STL
- BOG
1 stop16h 00m
United Airlines
Fri 7/312:14 am
BOG
- STL
1 stop9h 50m
United Airlines
Deal found 5/3![United Airlines logo]()
$661
This Copa Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1412:00 pm
MCI
- LIM
2 stops27h 40m
Copa Airlines
Tue 9/12:15 am
LIM
- MCI
2 stops17h 02m
Copa Airlines
Deal found 5/4![Copa Airlines logo]()
$842
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/145:16 am
STL
- LIM
1 stop17h 09m
American Airlines
Tue 6/2310:00 pm
LIM
- STL
1 stop12h 35m
American Airlines
Deal found 5/1![American Airlines logo]()
$856
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/216:00 am
STL
- BOG
1 stop13h 15m
Delta
Sun 6/282:55 pm
BOG
- STL
1 stop9h 01m
Delta
Deal found 5/2![Delta logo]()
$648
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:17 pm
STL
- GRU
1 stop34h 43m
Multiple Airlines
Fri 7/109:40 pm
GRU
- STL
2 stops28h 19m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$1,090
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/215:29 pm
STL
- MDE
2 stops27h 41m
United Airlines
Mon 7/69:45 am
MDE
- STL
2 stops26h 26m
United Airlines
Deal found 5/3![United Airlines logo]()
$699
Last-minute flights from Missouri to South AmericaDiscover last-minute flight deals from Missouri to South America. Data last updated May 6, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to South America. Data last updated May 6, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/128:36 am
STL
- BOG
1 stop14h 02m
American Airlines
Thu 7/26:30 am
BOG
- STL
1 stop16h 23m
American Airlines
Deal found 5/3![American Airlines logo]()
$651
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:31 pm
STL
- MDE
2 stops37h 44m
Multiple Airlines
Tue 6/236:35 am
MDE
- STL
1 stop17h 14m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$637
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/216:31 pm
STL
- BOG
2 stops26h 04m
Multiple Airlines
Tue 6/3010:35 am
BOG
- STL
1 stop13h 14m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$547
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/217:12 pm
STL
- BOG
2 stops22h 38m
Delta
Thu 7/22:55 pm
BOG
- STL
1 stop9h 01m
Delta
Deal found 5/2![Delta logo]()
$621
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/215:29 pm
STL
- MDE
2 stops27h 41m
United Airlines
Tue 6/309:45 am
MDE
- STL
2 stops26h 26m
United Airlines
Deal found 5/2![United Airlines logo]()
$625
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/215:29 am
STL
- BOG
1 stop17h 09m
American Airlines
Tue 6/302:10 pm
BOG
- STL
1 stop8h 47m
American Airlines
Deal found 5/2![American Airlines logo]()
$626
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/217:12 pm
STL
- BOG
2 stops22h 38m
Delta
Tue 6/308:40 am
BOG
- STL
2 stops15h 16m
Delta
Deal found 5/2![Delta logo]()
$633
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/217:04 am
STL
- BOG
1 stop15h 34m
American Airlines
Mon 6/292:10 pm
BOG
- STL
1 stop20h 25m
American Airlines
Deal found 5/2![American Airlines logo]()
$639
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/217:08 am
STL
- BOG
1 stop12h 07m
Delta
Mon 6/299:40 am
BOG
- STL
2 stops12h 38m
Delta
Deal found 5/2![Delta logo]()
$643
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/216:00 am
STL
- BOG
1 stop13h 15m
Delta
Sun 6/282:55 pm
BOG
- STL
1 stop9h 01m
Delta
Deal found 5/2![Delta logo]()
$648
This LATAM Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/226:00 am
STL
- BOG
2 stops12h 45m
LATAM Airlines
Fri 8/72:55 pm
BOG
- STL
1 stop8h 58m
LATAM Airlines
Deal found 5/2![LATAM Airlines logo]()
$625
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/227:12 pm
STL
- BOG
1 stop18h 28m
Delta
Fri 8/72:55 pm
BOG
- STL
1 stop18h 25m
Delta
Deal found 5/2![Delta logo]()
$638
One-way flights from Missouri to South AmericaSearch for one-way flight options from Missouri to South America. Find affordable one-way fares based on user searches. Data last updated May 6, 2026.
Search for one-way flight options from Missouri to South America. Find affordable one-way fares based on user searches. Data last updated May 6, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:27 pm
STL
- MDE
2 stops38h 48m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$168
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/275:06 pm
STL
- MDE
2 stops39h 09m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$182
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:33 pm
STL
- BOG
3 stops28h 22m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$200
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:27 pm
STL
- MDE
3 stops38h 48m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/66:24 pm
MCI
- BOG
3 stops59h 24m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$212
This Kiwi.com deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:27 pm
STL
- MDE
2 stops38h 48m
Multiple Airlines
Deal found 5/5![Multiple Airlines logo]()
$226
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/106:16 pm
MCI
- BOG
3 stops52h 54m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$227
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:24 pm
MCI
- LIM
3 stops34h 37m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$230
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/225:06 pm
STL
- LIM
3 stops59h 55m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/314:19 pm
STL
- BOG
2 stops31h 47m
Multiple Airlines
Deal found 5/2![Multiple Airlines logo]()
$258
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:24 pm
MCI
- LIM
3 stops58h 37m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/106:16 pm
MCI
- LIM
3 stops34h 45m
Multiple Airlines
Deal found 5/4![Multiple Airlines logo]()
$273
Find flight deals from Missouri to South America
Keep the following information in mind while searching for Missouri to South America flight deals. Data was last updated May 6, 2026.
Round-trip from | $547 (Kiwi.com) |
|---|---|
One-way from | $168 (Kiwi.com) |
Popular in | April |
Cheapest in | September |
Average price | $884 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 6, 2026.
Use the filters below to find and compare flights from Missouri to South America that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisBogotá
STL - BOG
STLBOG
Lambert-St Louis
Sun 6/21
7:12 pm-5:50 pm
2 stops22h 38m
Bogotá El Dorado
Thu 7/2
2:55 pm-11:56 pm
1 stop9h 01m
$621
St. LouisBogotá
STL - BOG
STLBOG
Lambert-St Louis
Tue 9/1
6:00 am-10:00 pm
2 stops16h 00m
Bogotá El Dorado
Thu 9/24
8:30 am-8:37 am
2 stops24h 07m
$621
St. LouisBogotá
STL - BOG
STLBOG
Lambert-St Louis
Sun 11/1
5:30 pm-4:45 pm
2 stops22h 15m
Bogotá El Dorado
Mon 11/16
7:00 am-8:49 pm
2 stops14h 49m
$621
St. LouisMedellín
STL - MDE
STLMDE
Lambert-St Louis
Sun 6/21
5:29 pm-9:10 pm
2 stops27h 41m
Medellín Jose Maria Cordova Intl
Tue 6/30
9:45 am-12:11 pm
2 stops26h 26m
$625
St. LouisBogotá
STL - BOG
STLBOG
Lambert-St Louis
Thu 9/3
9:00 am-8:35 pm
2 stops11h 35m
Bogotá El Dorado
Thu 9/17
2:55 pm-11:37 pm
1 stop8h 42m
$627
St. LouisBogotá
STL - BOG
STLBOG
Lambert-St Louis
Sat 8/29
7:30 am-10:00 pm
2 stops14h 30m
Bogotá El Dorado
Wed 9/23
8:30 am-9:22 pm
2 stops12h 52m
$631
St. LouisBogotá
STL - BOG
STLBOG
Lambert-St Louis
Sun 6/21
7:12 pm-5:50 pm
2 stops22h 38m
Bogotá El Dorado
Tue 6/30
8:40 am-11:56 pm
2 stops15h 16m
$633
St. LouisBogotá
STL - BOG
STLBOG
Lambert-St Louis
Sun 8/30
5:23 pm-1:40 pm
1 stop20h 17m
Bogotá El Dorado
Fri 9/18
10:35 am-11:37 pm
2 stops13h 02m
$636
St. LouisBogotá
STL - BOG
STLBOG
Lambert-St Louis
Wed 10/14
6:00 am-5:50 pm
2 stops11h 50m
Bogotá El Dorado
Mon 10/19
8:40 am-11:39 pm
2 stops14h 59m
$645
St. LouisBogotá
STL - BOG
STLBOG
Lambert-St Louis
Sun 6/21
6:00 am-7:15 pm
1 stop13h 15m
Bogotá El Dorado
Sun 6/28
2:55 pm-11:56 pm
1 stop9h 01m
$648
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Missouri to South America
Have a flexible travel schedule? Discover the best time to fly to South America from Missouri with our price prediction graph.
STL-BOG
STL-LIM
STL-MDE
MCI-MDE
MCI-BOG
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to South America
USMO-0SA
STL-BOG
STL-LIM
STL-MDE
MCI-MDE
How far ahead should I book a flight from Missouri to South America?
Booking 30 days in advance of your planned departure date is, on average, the best time to get cheap flights from Missouri to South America. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
What is the cheapest month to book a flight from Missouri to South America?
Currently, July is the cheapest month in which you can book a flight from Missouri to South America (average of $196). Flying from Missouri to South America in April is currently the most expensive (average of $474). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Missouri to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Return Flight Options
Top countries
Top destinations
Alternative routes for Missouri to South America
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South America by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to South America by cabin class
Find flights from Missouri to South America, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and South America flights
Browse other Missouri and South America flight options. Last updated on May 6, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South America
Find the right flight back to Missouri after your stay in South America
Fly to South America countries
Consider these flights traveling to countries located in South America.
Missouri to South America flights
Consider these flights traveling from Missouri to South America.
Top 6 airlines flying from Missouri to South America
Discover the top 6 airlines that operate flights from Missouri to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 6, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$303 | Average$378 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$351 | Average$960 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$474 | Average$671 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$474 | Average$876 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$563 | Average$982 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$823 | Average$980 | FlexibilityNo cancel fee | On-time74% |