$224+ Cheap flights from Missouri to South America
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/10. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BOG
Oct 24 — Oct 311
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to South America with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to South America
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Cheapest flights from Missouri to South AmericaExplore the most affordable flight options available from Missouri to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2026.
Explore the most affordable flight options available from Missouri to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2026.
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:00 am -
1 stop12h 30m
Wed 11/113:55 pm -
1 stop9h 01m
Deal found 9/20![Delta logo]()
$581
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2010:12 am -
1 stop12h 18m
Tue 10/2711:55 pm -
1 stop9h 25m
Deal found 9/22![American Airlines logo]()
$582
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:50 pm -
2 stops26h 45m
Tue 11/101:30 am -
2 stops14h 04m
Deal found 9/20![United Airlines logo]()
$586
This LATAM Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
1 stop7h 40m
Sun 10/253:55 pm -
1 stop17h 14m
Deal found 9/21![LATAM Airlines logo]()
$597
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:20 pm -
1 stop18h 20m
Mon 10/2610:45 am -
2 stops13h 09m
Deal found 9/21![Delta logo]()
$602
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:22 am -
2 stops12h 58m
Sat 11/1411:55 pm -
1 stop19h 21m
Deal found 9/23![American Airlines logo]()
$607
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:15 am -
1 stop15h 20m
Sat 11/71:30 am -
1 stop16h 20m
Deal found 9/23![United Airlines logo]()
$612
This LATAM Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:00 am -
1 stop13h 15m
Sat 11/73:55 pm -
1 stop18h 14m
Deal found 9/23![LATAM Airlines logo]()
$618
This BusinessClass deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:48 am -
1 stop13h 42m
Sun 10/252:00 pm -
2 stops20h 51m
Deal found 9/21![GOL logo]()
$624
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:20 pm -
1 stop18h 20m
Tue 10/202:55 pm -
1 stop8h 59m
Deal found 9/21![Delta logo]()
$685
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/112:10 pm -
2 stops27h 10m
Wed 12/93:55 pm -
1 stop9h 01m
Deal found 9/19![Delta logo]()
$685
This United Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:24 pm -
1 stop9h 46m
Tue 12/81:30 am -
1 stop11h 16m
Deal found 9/22![United Airlines logo]()
$686
Best flights from Missouri to South AmericaDiscover carefully curated flight deals from Missouri to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 24, 2026.
Discover carefully curated flight deals from Missouri to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 24, 2026.
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:00 am -
1 stop12h 30m
Tue 1/193:55 pm -
1 stop8h 44m
Deal found 9/22![Delta logo]()
$582
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/38:30 am -
1 stop13h 05m
Mon 11/91:30 am -
2 stops21h 10m
Deal found 9/19![United Airlines logo]()
$586
This FlightHub deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/255:59 pm -
1 stop17h 01m
Tue 2/21:10 pm -
2 stops22h 10m
Deal found 9/23![Frontier logo]()
$598
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:22 am -
2 stops12h 58m
Sat 11/1411:55 pm -
1 stop19h 21m
Deal found 9/23![American Airlines logo]()
$607
This LATAM Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/206:00 am -
1 stop14h 20m
Wed 2/101:30 pm -
2 stops22h 41m
Deal found 9/22![LATAM Airlines logo]()
$710
This Avianca deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:45 pm -
1 stop9h 45m
Sat 11/214:35 am -
2 stops16h 20m
Deal found 9/22![Multiple Airlines logo]()
$720
This Copa Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/137:36 am -
2 stops26h 31m
Sun 11/224:40 pm -
2 stops25h 50m
Deal found 9/23![Copa Airlines logo]()
$730
This GOL deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure GOL is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/211:19 am -
1 stop15h 56m
Tue 3/1610:25 pm -
1 stop18h 24m
Deal found 9/23![GOL logo]()
$1,123
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:15 am -
1 stop15h 20m
Sat 11/71:30 am -
1 stop16h 20m
Deal found 9/23![United Airlines logo]()
$612
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:20 pm -
1 stop18h 20m
Tue 10/202:55 pm -
1 stop8h 59m
Deal found 9/21![Delta logo]()
$685
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:02 am -
2 stops14h 18m
Mon 11/91:30 am -
2 stops13h 34m
Deal found 9/19![American Airlines logo]()
$692
This FlightHub deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/103:54 pm -
1 stop12h 06m
Thu 11/1912:10 pm -
1 stop12h 45m
Deal found 9/19![LATAM Airlines logo]()
$711
This Air Canada deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:55 am -
1 stop22h 10m
Mon 10/269:30 pm -
1 stop19h 53m
Deal found 9/19![Air Canada logo]()
$1,480
This United Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:24 pm -
1 stop9h 46m
Tue 12/81:30 am -
1 stop18h 02m
Deal found 9/20![United Airlines logo]()
$685
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:03 am -
2 stops13h 12m
Wed 11/47:30 am -
1 stop15h 17m
Deal found 9/22![American Airlines logo]()
$693
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/167:20 am -
1 stop11h 10m
Fri 1/224:50 am -
2 stops19h 49m
Deal found 9/19![Delta logo]()
$699
This Copa Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/227:30 am -
2 stops15h 50m
Thu 11/264:40 pm -
2 stops27h 43m
Deal found 9/21![Copa Airlines logo]()
$799
This LATAM Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/1011:40 am -
1 stop16h 20m
Sun 1/2411:40 pm -
1 stop17h 51m
Deal found 9/19![LATAM Airlines logo]()
$765
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:24 pm -
1 stop9h 46m
Mon 12/71:30 am -
1 stop11h 16m
Deal found 9/19![United Airlines logo]()
$707
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:10 am -
1 stop11h 20m
Tue 12/13:55 pm -
1 stop18h 34m
Deal found 9/20![Delta logo]()
$725
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:00 am -
1 stop17h 26m
Sun 11/1510:55 pm -
1 stop19h 30m
Deal found 9/20![American Airlines logo]()
$765
This FlightHub deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:40 am -
2 stops13h 50m
Thu 11/1212:10 pm -
1 stop12h 45m
Deal found 9/19![LATAM Airlines logo]()
$769
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/258:50 am -
1 stop12h 20m
Tue 2/210:40 am -
1 stop12h 33m
Deal found 9/23![United Airlines logo]()
$708
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/87:04 am -
1 stop12h 11m
Tue 10/206:30 pm -
2 stops17h 00m
Deal found 9/22![Delta logo]()
$726
This FlightHub deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/210:35 am -
1 stop9h 45m
Mon 3/1512:15 am -
2 stops16h 11m
Deal found 9/23![LATAM Airlines logo]()
$777
This United Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/211:29 pm -
2 stops31h 41m
Wed 11/410:40 am -
2 stops24h 52m
Deal found 9/23![United Airlines logo]()
$711
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:00 am -
2 stops25h 05m
Tue 12/812:10 pm -
1 stop11h 26m
Deal found 9/21![Delta logo]()
$735
This FlightHub deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/66:00 am -
2 stops12h 25m
Sun 1/318:40 pm -
2 stops27h 59m
Deal found 9/18![LATAM Airlines logo]()
$785
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:00 am -
2 stops25h 05m
Thu 11/1211:40 pm -
1 stop16h 01m
Deal found 9/21![Delta logo]()
$735
This GOL deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure GOL is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/112:54 pm -
2 stops20h 56m
Sun 2/2110:25 pm -
1 stop15h 02m
Deal found 9/20![GOL logo]()
$1,189
Last-minute flights from Missouri to South AmericaDiscover last-minute flight deals from Missouri to South America. Data last updated September 24, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to South America. Data last updated September 24, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/245:00 am -
1 stop16h 17m
Thu 10/12:10 pm -
1 stop9h 49m
Deal found 9/19![American Airlines logo]()
$701
This LATAM Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:00 am -
1 stop13h 15m
Sat 11/73:55 pm -
1 stop18h 14m
Deal found 9/23![LATAM Airlines logo]()
$618
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:32 am -
1 stop15h 58m
Sat 11/77:50 am -
2 stops15h 49m
Deal found 9/23![American Airlines logo]()
$693
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:20 pm -
1 stop18h 20m
Tue 10/202:55 pm -
1 stop8h 59m
Deal found 9/21![Delta logo]()
$685
This LATAM Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:20 pm -
1 stop18h 20m
Tue 10/2010:35 am -
2 stops10h 48m
Deal found 9/21![Multiple Airlines logo]()
$690
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/179:48 am -
1 stop12h 42m
Sat 10/2411:55 pm -
1 stop9h 02m
Deal found 9/19![American Airlines logo]()
$685
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2010:12 am -
1 stop12h 18m
Tue 10/2711:55 pm -
1 stop9h 25m
Deal found 9/22![American Airlines logo]()
$582
This LATAM Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:00 am -
1 stop7h 40m
Sun 10/253:55 pm -
1 stop17h 14m
Deal found 9/21![LATAM Airlines logo]()
$597
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:40 am -
2 stops14h 35m
Wed 11/47:30 am -
1 stop15h 17m
Deal found 9/20![American Airlines logo]()
$692
This BusinessClass deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:48 am -
1 stop13h 42m
Sun 10/252:00 pm -
2 stops20h 51m
Deal found 9/21![GOL logo]()
$624
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:20 pm -
1 stop18h 20m
Mon 10/2610:45 am -
2 stops13h 09m
Deal found 9/21![Delta logo]()
$602
This FlightHub deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:35 pm -
1 stop11h 25m
Mon 11/912:10 pm -
1 stop12h 46m
Deal found 9/20![LATAM Airlines logo]()
$696
One-way flights from Missouri to South AmericaSearch for one-way flight options from Missouri to South America. Find affordable one-way fares based on user searches. Data last updated September 24, 2026.
Search for one-way flight options from Missouri to South America. Find affordable one-way fares based on user searches. Data last updated September 24, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/108:43 pm -
3 stops38h 08m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Multiple Airlines logo]()
$224
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:35 pm -
3 stops59h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/19![Multiple Airlines logo]()
$241
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:35 pm -
3 stops29h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/19![Multiple Airlines logo]()
$258
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:44 pm -
2 stops24h 26m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![Multiple Airlines logo]()
$285
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/148:43 pm -
2 stops35h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$293
This Kiwi.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/218:43 pm -
3 stops52h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Multiple Airlines logo]()
$303
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/118:43 pm -
2 stops21h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:35 pm -
2 stops33h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![Multiple Airlines logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/128:43 pm -
2 stops35h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$311
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/912:02 pm -
2 stops46h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/19![Frontier logo]()
$321
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:43 pm -
2 stops21h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$321
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/178:43 pm -
3 stops47h 37m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/19![Multiple Airlines logo]()
$322
Find flight deals from Missouri to South America
Keep the following information in mind while searching for Missouri to South America flight deals. Data was last updated September 24, 2026.
Round-trip from | $581 (Delta) |
|---|---|
One-way from | $224 (Kiwi.com) |
Popular in | April |
Cheapest in | June |
Average price | $985 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 24, 2026.
Use the filters below to find and compare flights from Missouri to South America that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Kansas CityBogotá
MCI Kansas City - BOG Bogotá El Dorado
MCIBOG
Kansas City
Tue 11/10
8:43 pm-11:51 am
3 stops38h 08m
Bogotá El Dorado
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$224
St. LouisBogotá
STL Lambert-St Louis - BOG Bogotá El Dorado
STLBOG
Lambert-St Louis
Fri 10/23
6:35 pm-6:10 am
3 stops59h 35m
Bogotá El Dorado
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$241
St. LouisBogotá
STL Lambert-St Louis - BOG Bogotá El Dorado
STLBOG
Lambert-St Louis
Wed 10/21
6:35 pm-8:10 pm
2 stops25h 35m
Bogotá El Dorado
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$280
Kansas CityBogotá
MCI Kansas City - BOG Bogotá El Dorado
MCIBOG
Kansas City
Wed 10/21
8:43 pm-10:08 am
2 stops37h 25m
Bogotá El Dorado
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$314
St. LouisMedellín
STL Lambert-St Louis - MDE Medellín Jose Maria Cordova Intl
STLMDE
Lambert-St Louis
Wed 12/9
12:02 pm-12:00 pm
2 stops46h 58m
Medellín Jose Maria Cordova Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$321
Kansas CityBogotá
MCI Kansas City - BOG Bogotá El Dorado
MCIBOG
Kansas City
Mon 11/9
8:43 pm-7:30 pm
2 stops21h 47m
Bogotá El Dorado
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$321
Kansas CityBogotá
MCI Kansas City - BOG Bogotá El Dorado
MCIBOG
Kansas City
Sat 10/17
8:43 pm-8:20 pm
3 stops47h 37m
Bogotá El Dorado
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$322
Kansas CityBogotá
MCI Kansas City - BOG Bogotá El Dorado
MCIBOG
Kansas City
Wed 11/18
6:45 pm-5:30 am
1 stop9h 45m
Bogotá El Dorado
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$339
St. LouisMedellín
STL Lambert-St Louis - MDE Medellín Jose Maria Cordova Intl
STLMDE
Lambert-St Louis
Wed 9/30
2:29 pm-7:54 am
3 stops41h 25m
Medellín Jose Maria Cordova Intl
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$342
St. LouisBogotá
STL Lambert-St Louis - BOG Bogotá El Dorado
STLBOG
Lambert-St Louis
Thu 10/22
4:30 pm-10:55 pm
2 stops30h 25m
Bogotá El Dorado
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$349
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Missouri to South America
Have a flexible travel schedule? Discover the best time to fly to South America from Missouri with our price prediction graph.
MCI-BOG
STL-MDE
STL-BOG
STL-EZE
MCI-EZE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to South America
USMO-0SA
MCI-BOG
STL-MDE
STL-BOG
STL-EZE
What is the cheapest month to book a flight from Missouri to South America?
Currently, April is the cheapest month in which you can book a flight from Missouri to South America (average of $801). Flying from Missouri to South America in December is currently the most expensive (average of $1,103). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How far ahead should I book a flight from Missouri to South America?
Booking 29 days in advance of your planned departure date is, on average, the best time to get cheap flights from Missouri to South America. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
Related info for your journey
Find useful and relevant information for your journey from Missouri to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Missouri to South America
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South America by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to South America by cabin class
Find flights from Missouri to South America, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and South America flights
Browse other Missouri and South America flight options. Last updated on September 24, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South America
Find the right flight back to Missouri after your stay in South America
Fly to South America countries
Consider these flights traveling to countries located in South America.
Missouri to South America flights
Consider these flights traveling from Missouri to South America.
Top 5 airlines flying from Missouri to South America
Discover the top 5 airlines that operate flights from Missouri to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$516 | Average$923 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$536 | Average$939 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$541 | Average$1,013 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$615 | Average$957 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$801 | Average$1,005 | FlexibilityNo cancel fee | On-time74% |