$224+ Cheap flights from Missouri to South America
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/10. Fares are subject to change and may not be available on all flights or dates of travel.
MCI — BOG
Jul 27 — Aug 31
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to South America with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to South America
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Cheapest flights from Missouri to South AmericaExplore the most affordable flight options available from Missouri to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 27, 2026.
Explore the most affordable flight options available from Missouri to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 27, 2026.
This Orbitz deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/14:05 pm
STL
- LIM
1 stop13h 05m
Air Canada
Sat 12/58:00 am
LIM
- STL
2 stops32h 26m
Air Canada
Deal found 6/24![Air Canada logo]()
$602
This Air Canada deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/94:05 pm
STL
- LIM
2 stops17h 40m
Multiple Airlines
Sun 11/225:35 pm
LIM
- STL
2 stops46h 51m
Multiple Airlines
Deal found 6/25![Multiple Airlines logo]()
$609
This United Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/168:35 am
STL
- MDE
1 stop12h 35m
United Airlines
Mon 9/289:45 am
MDE
- STL
1 stop12h 45m
United Airlines
Deal found 6/23![United Airlines logo]()
$630
This Expedia deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/54:05 pm
STL
- LIM
1 stop13h 05m
Air Canada
Thu 12/248:00 am
LIM
- STL
2 stops32h 26m
Air Canada
Deal found 6/24![Air Canada logo]()
$630
This Orbitz deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/172:40 pm
STL
- MDE
2 stops22h 30m
Multiple Airlines
Sun 8/232:10 pm
MDE
- STL
2 stops23h 52m
Multiple Airlines
Deal found 6/23![Multiple Airlines logo]()
$642
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:08 pm
STL
- MDE
1 stop18h 27m
American Airlines
Wed 10/283:05 pm
MDE
- STL
1 stop8h 10m
American Airlines
Deal found 6/24![American Airlines logo]()
$643
This United Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:15 am
STL
- MDE
1 stop14h 55m
United Airlines
Tue 10/279:45 am
MDE
- STL
1 stop12h 35m
United Airlines
Deal found 6/25![United Airlines logo]()
$645
This United Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/145:08 pm
MCI
- BOG
2 stops11h 46m
United Airlines
Tue 9/2212:14 am
BOG
- MCI
1 stop9h 52m
United Airlines
Deal found 6/22![United Airlines logo]()
$649
This Avianca deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:42 pm
MCI
- BOG
2 stops17h 08m
Avianca
Sat 11/147:50 am
BOG
- MCI
1 stop12h 53m
Avianca
Deal found 6/24![Avianca logo]()
$652
This United Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/216:15 am
STL
- MDE
1 stop14h 55m
United Airlines
Mon 8/319:45 am
MDE
- STL
1 stop24h 25m
United Airlines
Deal found 6/25![United Airlines logo]()
$655
This United Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/168:35 am
STL
- MDE
1 stop12h 35m
United Airlines
Mon 9/219:45 am
MDE
- STL
2 stops26h 12m
United Airlines
Deal found 6/25![United Airlines logo]()
$659
This Delta deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/510:27 am
MCI
- BOG
1 stop8h 48m
Delta
Sun 10/189:00 am
BOG
- MCI
1 stop12h 05m
Delta
Deal found 6/26![Delta logo]()
$659
Best flights from Missouri to South AmericaDiscover carefully curated flight deals from Missouri to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 27, 2026.
Discover carefully curated flight deals from Missouri to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 27, 2026.
This United Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/168:35 am
STL
- MDE
1 stop12h 35m
United Airlines
Mon 9/289:45 am
MDE
- STL
1 stop12h 45m
United Airlines
Deal found 6/26![United Airlines logo]()
$630
This Air Canada deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/94:05 pm
STL
- LIM
2 stops17h 40m
Multiple Airlines
Sun 11/225:35 pm
LIM
- STL
2 stops46h 51m
Multiple Airlines
Deal found 6/24![Multiple Airlines logo]()
$637
This American Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:08 pm
STL
- MDE
1 stop18h 27m
American Airlines
Wed 10/285:45 am
MDE
- STL
2 stops12h 29m
American Airlines
Deal found 6/27![American Airlines logo]()
$648
This Delta deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/510:27 am
MCI
- BOG
1 stop8h 48m
Delta
Sun 10/189:00 am
BOG
- MCI
1 stop12h 05m
Delta
Deal found 6/26![Delta logo]()
$659
This Justfly.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/129:00 am
STL
- LIM
2 stops11h 40m
LATAM Airlines
Mon 12/218:15 am
LIM
- STL
2 stops16h 24m
LATAM Airlines
Deal found 6/22![LATAM Airlines logo]()
$729
This Air Canada deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/24:05 pm
STL
- LIM
2 stops17h 40m
Air Canada
Fri 12/48:00 am
LIM
- STL
1 stop32h 26m
Air Canada
Deal found 6/26![Air Canada logo]()
$799
This GOL deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure GOL is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/74:50 pm
MCI
- GIG
1 stop13h 30m
GOL
Mon 10/198:15 pm
GIG
- MCI
2 stops21h 55m
GOL
Deal found 6/23![GOL logo]()
$986
This United Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:15 am
STL
- MDE
1 stop14h 55m
United Airlines
Tue 10/279:45 am
MDE
- STL
1 stop12h 35m
United Airlines
Deal found 6/25![United Airlines logo]()
$645
This Delta deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:55 pm
MCI
- BOG
2 stops22h 55m
Delta
Sat 11/143:55 pm
BOG
- MCI
1 stop18h 40m
Delta
Deal found 6/26![Delta logo]()
$664
This American Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/275:00 am
MCI
- MDE
1 stop15h 16m
American Airlines
Wed 12/307:00 am
MDE
- MCI
1 stop18h 44m
American Airlines
Deal found 6/25![American Airlines logo]()
$671
This United Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/145:08 pm
MCI
- BOG
2 stops11h 46m
United Airlines
Tue 9/2212:14 am
BOG
- MCI
1 stop9h 52m
United Airlines
Deal found 6/22![United Airlines logo]()
$649
This oojo deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/206:45 pm
STL
- LIM
2 stops26h 55m
LATAM Airlines
Mon 10/51:30 pm
LIM
- STL
2 stops21h 18m
LATAM Airlines
Deal found 6/27![LATAM Airlines logo]()
$748
This American Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/259:45 am
MCI
- BOG
1 stop12h 45m
American Airlines
Tue 8/46:30 am
BOG
- MCI
1 stop16h 26m
American Airlines
Deal found 6/25![American Airlines logo]()
$705
This United Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/215:30 pm
STL
- MDE
2 stops27h 40m
United Airlines
Mon 8/319:45 am
MDE
- STL
1 stop24h 25m
United Airlines
Deal found 6/25![United Airlines logo]()
$659
This KAYAK deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:40 am
MCI
- MDE
2 stops14h 25m
LATAM Airlines
Mon 10/1211:10 pm
MDE
- MCI
2 stops24h 48m
LATAM Airlines
Deal found 6/27![LATAM Airlines logo]()
$774
This American Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/245:31 am
MCI
- BOG
1 stop16h 59m
American Airlines
Tue 8/46:30 am
BOG
- MCI
1 stop16h 26m
American Airlines
Deal found 6/25![American Airlines logo]()
$715
This Delta deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/116:00 am
STL
- LIM
1 stop15h 00m
Delta
Tue 10/2012:05 am
LIM
- STL
1 stop15h 44m
Delta
Deal found 6/26![Delta logo]()
$790
This United Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:00 am
STL
- MDE
2 stops15h 10m
United Airlines
Mon 9/219:45 am
MDE
- STL
2 stops26h 12m
United Airlines
Deal found 6/25![United Airlines logo]()
$659
This Air Canada deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/238:55 am
STL
- GRU
2 stops22h 55m
Air Canada
Wed 9/309:00 pm
GRU
- STL
2 stops19h 00m
Air Canada
Deal found 6/26![Air Canada logo]()
$911
This Delta deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/911:51 am
STL
- LIM
1 stop17h 09m
Delta
Sun 11/2212:00 pm
LIM
- STL
1 stop21h 12m
Delta
Deal found 6/22![Delta logo]()
$790
This United Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/186:39 pm
MCI
- BOG
2 stops24h 41m
United Airlines
Fri 11/131:30 am
BOG
- MCI
2 stops13h 53m
United Airlines
Deal found 6/26![United Airlines logo]()
$664
This American Airlines deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:11 am
MCI
- MDE
1 stop7h 24m
American Airlines
Mon 10/125:45 am
MDE
- MCI
1 stop16h 15m
American Airlines
Deal found 6/26![American Airlines logo]()
$745
This GOL deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure GOL is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:08 pm
STL
- GIG
2 stops51h 02m
GOL
Mon 10/198:15 pm
GIG
- STL
2 stops23h 08m
GOL
Deal found 6/22![GOL logo]()
$993
This LATAM Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:00 am
STL
- LIM
2 stops12h 25m
LATAM Airlines
Fri 11/68:40 pm
LIM
- STL
2 stops22h 21m
LATAM Airlines
Deal found 6/23![LATAM Airlines logo]()
$829
This Kiwi.com deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/14:09 pm
STL
- GRU
2 stops33h 26m
Multiple Airlines
Thu 8/611:35 am
GRU
- STL
1 stop14h 24m
Multiple Airlines
Deal found 6/26![Multiple Airlines logo]()
$1,046
This United Airlines deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:36 pm
STL
- MDE
2 stops27h 34m
United Airlines
Wed 10/289:45 am
MDE
- STL
2 stops24h 56m
United Airlines
Deal found 6/27![United Airlines logo]()
$667
This GOL deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure GOL is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/84:50 pm
MCI
- GIG
1 stop13h 35m
GOL
Sat 11/1411:55 pm
GIG
- MCI
1 stop27h 04m
GOL
Deal found 6/24![GOL logo]()
$1,033
This United Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2811:15 am
STL
- MDE
1 stop9h 55m
United Airlines
Tue 9/19:45 am
MDE
- STL
2 stops22h 54m
United Airlines
Deal found 6/25![United Airlines logo]()
$674
This American Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/122:09 pm
STL
- LIM
2 stops14h 01m
American Airlines
Sun 12/2012:45 am
LIM
- STL
1 stop18h 06m
American Airlines
Deal found 6/22![American Airlines logo]()
$817
This Delta deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/146:00 am
STL
- LIM
2 stops14h 20m
Delta
Mon 7/2712:05 am
LIM
- STL
2 stops17h 19m
Delta
Deal found 6/23![Delta logo]()
$920
Last-minute flights from Missouri to South AmericaDiscover last-minute flight deals from Missouri to South America. Data last updated June 27, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to South America. Data last updated June 27, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:18 am
STL
- MDE
1 stop18h 30m
American Airlines
Tue 7/216:00 am
MDE
- STL
1 stop16h 54m
American Airlines
Deal found 6/23![American Airlines logo]()
$728
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/166:39 am
MCI
- BOG
1 stop15h 51m
American Airlines
Mon 8/172:10 pm
BOG
- MCI
1 stop9h 49m
American Airlines
Deal found 6/24![American Airlines logo]()
$717
This American Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/215:18 am
STL
- MDE
1 stop18h 30m
American Airlines
Sat 7/2512:30 am
MDE
- STL
1 stop9h 54m
American Airlines
Deal found 6/23![American Airlines logo]()
$724
This Avianca deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/228:30 am
MCI
- BOG
2 stops17h 30m
Multiple Airlines
Sat 7/254:25 am
BOG
- MCI
2 stops18h 06m
Multiple Airlines
Deal found 6/26![Multiple Airlines logo]()
$716
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/245:53 pm
MCI
- BOG
1 stop17h 27m
American Airlines
Tue 7/2812:25 am
BOG
- MCI
1 stop11h 19m
American Airlines
Deal found 6/24![American Airlines logo]()
$714
This American Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/245:31 am
MCI
- BOG
1 stop16h 59m
American Airlines
Tue 8/46:30 am
BOG
- MCI
1 stop16h 26m
American Airlines
Deal found 6/25![American Airlines logo]()
$715
This American Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/259:45 am
MCI
- BOG
1 stop12h 45m
American Airlines
Thu 8/1312:25 am
BOG
- MCI
1 stop11h 18m
American Airlines
Deal found 6/25![American Airlines logo]()
$697
This American Airlines deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/256:39 am
MCI
- BOG
1 stop15h 51m
American Airlines
Tue 8/412:20 pm
BOG
- MCI
1 stop10h 36m
American Airlines
Deal found 6/24![American Airlines logo]()
$705
This KAYAK deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/255:39 am
MCI
- BOG
2 stops11h 01m
LATAM Airlines
Tue 8/410:05 am
BOG
- MCI
2 stops13h 53m
LATAM Airlines
Deal found 6/27![LATAM Airlines logo]()
$733
This American Airlines deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/275:00 am
MCI
- MDE
1 stop15h 16m
American Airlines
Wed 12/307:00 am
MDE
- MCI
1 stop18h 44m
American Airlines
Deal found 6/25![American Airlines logo]()
$671
This oojo deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/275:45 pm
MCI
- MDE
2 stops19h 25m
Avianca
Wed 12/302:10 pm
MDE
- MCI
2 stops25h 40m
Avianca
Deal found 6/25![Avianca logo]()
$719
This United Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:16 am
MCI
- BOG
1 stop13h 04m
United Airlines
Fri 8/77:20 am
BOG
- MCI
1 stop16h 39m
United Airlines
Deal found 6/23![United Airlines logo]()
$724
One-way flights from Missouri to South AmericaSearch for one-way flight options from Missouri to South America. Find affordable one-way fares based on user searches. Data last updated June 27, 2026.
Search for one-way flight options from Missouri to South America. Find affordable one-way fares based on user searches. Data last updated June 27, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/106:07 pm
MCI
- BOG
3 stops37h 03m
Multiple Airlines
Deal found 6/23![Multiple Airlines logo]()
$224
This Kiwi.com deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:11 pm
MCI
- EZE
3 stops30h 49m
Multiple Airlines
Deal found 6/27![Multiple Airlines logo]()
$276
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:07 pm
MCI
- BOG
3 stops30h 15m
Multiple Airlines
Deal found 6/22![Multiple Airlines logo]()
$308
This Kiwi.com deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:27 pm
STL
- MDE
3 stops38h 48m
Multiple Airlines
Deal found 6/27![Multiple Airlines logo]()
$316
This Kiwi.com deal was found by Cheapflights users on 6/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/85:27 pm
STL
- MDE
3 stops38h 48m
Multiple Airlines
Deal found 6/27![Multiple Airlines logo]()
$326
This Kiwi.com deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/166:34 pm
STL
- GRU
3 stops36h 06m
Multiple Airlines
Deal found 6/26![Multiple Airlines logo]()
$329
This Avianca deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:42 pm
MCI
- MDE
2 stops18h 13m
Avianca
Deal found 6/24![Avianca logo]()
$330
This Kiwi.com deal was found by Cheapflights users on 6/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:07 pm
MCI
- BOG
3 stops56h 53m
Multiple Airlines
Deal found 6/25![Multiple Airlines logo]()
$330
This Kiwi.com deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/106:07 pm
MCI
- BOG
3 stops30h 15m
Multiple Airlines
Deal found 6/24![Multiple Airlines logo]()
$341
This Avianca deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/266:45 pm
MCI
- MDE
2 stops13h 00m
Multiple Airlines
Deal found 6/23![Multiple Airlines logo]()
$342
This Kiwi.com deal was found by Cheapflights users on 6/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/211:45 pm
MCI
- MDE
3 stops42h 30m
Multiple Airlines
Deal found 6/26![Multiple Airlines logo]()
$346
This Kiwi.com deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/141:45 pm
MCI
- BOG
2 stops20h 23m
Multiple Airlines
Deal found 6/22![Multiple Airlines logo]()
$355
Find flight deals from Missouri to South America
Keep the following information in mind while searching for Missouri to South America flight deals. Data was last updated June 27, 2026.
Round-trip from | $602 (Orbitz) |
|---|---|
One-way from | $224 (Kiwi.com) |
Popular in | April |
Cheapest in | June |
Average price | $438 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 27, 2026.
Use the filters below to find and compare flights from Missouri to South America that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisMedellín
STL - MDE
STLMDE
Lambert-St Louis
Wed 9/16
8:35 am-9:10 pm
1 stop12h 35m
Medellín Jose Maria Cordova Intl
Mon 9/28
9:45 am-10:30 pm
1 stop12h 45m
$630
St. LouisLima
STL - LIM
STLLIM
Lambert-St Louis
Mon 11/9
4:05 pm-10:45 am
2 stops17h 40m
Lima J Chavez Intl
Sun 11/22
5:35 pm-3:26 pm
2 stops46h 51m
$637
St. LouisMedellín
STL - MDE
STLMDE
Lambert-St Louis
Sat 10/17
6:15 am-9:10 pm
1 stop14h 55m
Medellín Jose Maria Cordova Intl
Tue 10/27
9:45 am-10:20 pm
1 stop12h 35m
$645
St. LouisMedellín
STL - MDE
STLMDE
Lambert-St Louis
Fri 10/16
6:08 pm-12:35 pm
1 stop18h 27m
Medellín Jose Maria Cordova Intl
Wed 10/28
5:45 am-6:14 pm
2 stops12h 29m
$648
Kansas CityBogotá
MCI - BOG
MCIBOG
Kansas City
Mon 9/14
5:08 pm-4:54 am
2 stops11h 46m
Bogotá El Dorado
Tue 9/22
12:14 am-10:06 am
1 stop9h 52m
$649
Quickest round-trip
Kansas CityBogotá
MCI - BOG
MCIBOG
Kansas City
Mon 10/5
10:27 am-7:15 pm
1 stop8h 48m
Bogotá El Dorado
Sun 10/18
9:00 am-9:05 pm
1 stop12h 05m
$659
St. LouisMedellín
STL - MDE
STLMDE
Lambert-St Louis
Fri 8/21
5:30 pm-9:10 pm
2 stops27h 40m
Medellín Jose Maria Cordova Intl
Mon 8/31
9:45 am-10:10 am
1 stop24h 25m
$659
St. LouisMedellín
STL - MDE
STLMDE
Lambert-St Louis
Wed 9/16
6:00 am-9:10 pm
2 stops15h 10m
Medellín Jose Maria Cordova Intl
Mon 9/21
9:45 am-11:57 am
2 stops26h 12m
$659
Kansas CityBogotá
MCI - BOG
MCIBOG
Kansas City
Sun 10/18
6:55 pm-5:50 pm
2 stops22h 55m
Bogotá El Dorado
Sat 11/14
3:55 pm-9:35 am
1 stop18h 40m
$664
Kansas CityBogotá
MCI - BOG
MCIBOG
Kansas City
Sun 10/18
6:39 pm-7:20 pm
2 stops24h 41m
Bogotá El Dorado
Fri 11/13
1:30 am-2:23 pm
2 stops13h 53m
$664
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Missouri to South America
Have a flexible travel schedule? Discover the best time to fly to South America from Missouri with our price prediction graph.
STL-MDE
STL-LIM
MCI-BOG
MCI-GIG
MCI-MDE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to South America
USMO-0SA
STL-MDE
STL-LIM
MCI-BOG
MCI-GIG
What is the cheapest month to book a flight from Missouri to South America?
Currently, July is the cheapest month in which you can book a flight from Missouri to South America (average of $178). Flying from Missouri to South America in April is currently the most expensive (average of $476). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How far ahead should I book a flight from Missouri to South America?
Booking 48 days in advance of your planned departure date is, on average, the best time to get cheap flights from Missouri to South America. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
Related info for your journey
Find useful and relevant information for your journey from Missouri to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Missouri to South America
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South America by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to South America by cabin class
Find flights from Missouri to South America, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and South America flights
Browse other Missouri and South America flight options. Last updated on June 27, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South America
Find the right flight back to Missouri after your stay in South America
Fly to South America countries
Consider these flights traveling to countries located in South America.
Missouri to South America flights
Consider these flights traveling from Missouri to South America.
Top 5 airlines flying from Missouri to South America
Discover the top 5 airlines that operate flights from Missouri to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 27, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$351 | Average$918 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$552 | Average$892 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$554 | Average$1,012 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$615 | Average$696 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$801 | Average$1,004 | FlexibilityNo cancel fee | On-time74% |