$211+ Cheap flights from Missouri to South America
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/30. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BOG
Sep 9 — Sep 161
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to South America with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to South America
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Cheapest flights from Missouri to South AmericaExplore the most affordable flight options available from Missouri to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 10, 2026.
Explore the most affordable flight options available from Missouri to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 10, 2026.
This Expedia deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/142:40 pm -
2 stops27h 10m
Tue 10/275:50 pm -
2 stops21h 36m
Deal found 8/5![Multiple Airlines logo]()
$632
This Expedia deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/228:55 am -
2 stops28h 15m
Wed 11/45:35 pm -
2 stops22h 51m
Deal found 8/8![Multiple Airlines logo]()
$643
This Expedia deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/212:40 pm -
2 stops19h 40m
Tue 11/33:55 pm -
2 stops24h 31m
Deal found 8/5![Multiple Airlines logo]()
$653
This FlightHub deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:31 pm -
1 stop10h 29m
Wed 11/1812:15 am -
2 stops13h 00m
Deal found 8/5![LATAM Airlines logo]()
$654
This Orbitz deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:55 am -
2 stops28h 15m
Tue 10/61:15 pm -
2 stops24h 45m
Deal found 8/6![Multiple Airlines logo]()
$663
This Expedia deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/284:05 pm -
2 stops18h 40m
Wed 11/42:55 am -
2 stops37h 31m
Deal found 8/8![Multiple Airlines logo]()
$666
This Orbitz deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/314:05 pm -
1 stop13h 05m
Sat 11/78:00 am -
2 stops32h 26m
Deal found 8/8![Air Canada logo]()
$680
This FlightHub deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/155:44 am -
2 stops15h 56m
Mon 9/2112:15 am -
2 stops18h 45m
Deal found 8/7![LATAM Airlines logo]()
$683
This Air Canada deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/284:05 pm -
2 stops34h 10m
Sat 12/58:00 am -
2 stops32h 26m
Deal found 8/5![Air Canada logo]()
$683
This Expedia deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/162:40 pm -
2 stops46h 30m
Tue 9/291:15 pm -
2 stops24h 45m
Deal found 8/5![Multiple Airlines logo]()
$684
This Expedia deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/304:05 pm -
2 stops59h 10m
Sat 11/78:00 am -
2 stops32h 26m
Deal found 8/8![Air Canada logo]()
$684
This FlightHub deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1512:00 pm -
2 stops17h 00m
Tue 9/2912:05 pm -
1 stop11h 37m
Deal found 8/10![LATAM Airlines logo]()
$685
Best flights from Missouri to South AmericaDiscover carefully curated flight deals from Missouri to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 10, 2026.
Discover carefully curated flight deals from Missouri to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 10, 2026.
This Air Canada deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/284:05 pm -
1 stop13h 05m
Sat 12/58:00 am -
2 stops32h 26m
Deal found 8/5![Air Canada logo]()
$680
This FlightHub deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/155:44 am -
2 stops15h 56m
Mon 9/2112:15 am -
2 stops18h 45m
Deal found 8/7![LATAM Airlines logo]()
$683
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:15 am -
1 stop14h 55m
Tue 10/279:45 am -
1 stop12h 41m
Deal found 8/5![United Airlines logo]()
$690
This American Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:07 pm -
1 stop18h 41m
Wed 10/286:00 am -
2 stops13h 18m
Deal found 8/8![American Airlines logo]()
$709
This CheapOair deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/282:40 pm -
2 stops22h 30m
Tue 9/12:10 pm -
2 stops19h 29m
Deal found 8/9![Multiple Airlines logo]()
$732
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/3110:25 am -
1 stop18h 35m
Mon 9/1412:05 pm -
1 stop11h 46m
Deal found 8/5![Delta logo]()
$745
This Copa Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/167:32 am -
2 stops17h 48m
Tue 9/222:35 am -
2 stops17h 03m
Deal found 8/5![Copa Airlines logo]()
$748
This oojo deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2412:10 pm -
3 stops28h 45m
Sat 8/292:10 pm -
2 stops29h 22m
Deal found 8/5![Avianca logo]()
$813
This GOL deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure GOL is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:20 pm -
2 stops18h 50m
Mon 10/198:15 pm -
2 stops22h 01m
Deal found 8/6![GOL logo]()
$918
This FlightHub deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1512:00 pm -
2 stops17h 00m
Tue 9/2912:05 pm -
1 stop11h 37m
Deal found 8/10![LATAM Airlines logo]()
$685
This United Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:15 am -
1 stop14h 55m
Wed 11/410:40 am -
1 stop8h 58m
Deal found 8/8![United Airlines logo]()
$690
This American Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/55:00 am -
1 stop7h 48m
Thu 10/86:00 am -
1 stop11h 27m
Deal found 8/8![American Airlines logo]()
$763
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2610:25 am -
2 stops21h 40m
Wed 9/212:05 am -
1 stop14h 48m
Deal found 8/6![Delta logo]()
$765
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/168:35 am -
1 stop12h 35m
Mon 9/289:45 am -
1 stop12h 45m
Deal found 8/5![United Airlines logo]()
$699
This LATAM Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/66:00 am -
2 stops12h 25m
Wed 1/2012:10 pm -
1 stop12h 29m
Deal found 8/5![Multiple Airlines logo]()
$785
This Copa Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/315:39 pm -
2 stops31h 16m
Mon 9/144:40 pm -
2 stops26h 52m
Deal found 8/5![Copa Airlines logo]()
$824
This Delta deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2610:25 am -
2 stops21h 40m
Wed 9/912:05 pm -
1 stop11h 46m
Deal found 8/6![Delta logo]()
$765
This LATAM Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/25:43 am -
2 stops15h 52m
Tue 9/812:05 pm -
1 stop11h 46m
Deal found 8/9![LATAM Airlines logo]()
$765
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/61:06 pm -
2 stops15h 04m
Wed 1/137:00 am -
1 stop11h 24m
Deal found 8/5![American Airlines logo]()
$770
This United Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/228:30 am -
1 stop12h 40m
Tue 9/299:45 am -
1 stop12h 50m
Deal found 8/8![United Airlines logo]()
$707
This Avianca deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/285:39 pm -
2 stops19h 31m
Mon 8/314:50 am -
2 stops14h 42m
Deal found 8/6![Multiple Airlines logo]()
$840
This LATAM Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/69:00 am -
2 stops22h 10m
Wed 1/139:00 am -
2 stops26h 48m
Deal found 8/5![LATAM Airlines logo]()
$774
This Delta deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/63:40 pm -
1 stop12h 20m
Wed 1/2012:00 pm -
1 stop12h 39m
Deal found 8/5![Delta logo]()
$785
This American Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/202:11 pm -
1 stop13h 59m
Mon 10/511:45 pm -
1 stop18h 04m
Deal found 8/10![American Airlines logo]()
$785
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:15 am -
1 stop14h 55m
Tue 10/69:45 am -
1 stop28h 25m
Deal found 8/6![United Airlines logo]()
$725
This LATAM Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/69:00 am -
2 stops22h 10m
Wed 1/2012:10 pm -
1 stop12h 29m
Deal found 8/9![LATAM Airlines logo]()
$785
This Delta deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/712:52 pm -
1 stop16h 08m
Mon 9/2112:05 pm -
1 stop11h 37m
Deal found 8/9![Delta logo]()
$785
This American Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:32 pm -
2 stops18h 16m
Sat 10/171:50 pm -
1 stop9h 09m
Deal found 8/7![American Airlines logo]()
$793
This United Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/238:30 am -
1 stop12h 40m
Wed 9/309:45 am -
1 stop12h 50m
Deal found 8/8![United Airlines logo]()
$737
This GOL deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure GOL is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/96:07 pm -
2 stops34h 48m
Sun 10/186:00 am -
2 stops37h 27m
Deal found 8/6![GOL logo]()
$1,156
Last-minute flights from Missouri to South AmericaDiscover last-minute flight deals from Missouri to South America. Data last updated August 10, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to South America. Data last updated August 10, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/65:00 am -
2 stops15h 15m
Sat 9/126:00 am -
2 stops16h 42m
Deal found 8/5![American Airlines logo]()
$724
This CheapOair deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/92:40 pm -
2 stops27h 30m
Mon 9/147:40 pm -
2 stops24h 40m
Deal found 8/8![Multiple Airlines logo]()
$717
This FlightHub deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/155:44 am -
2 stops15h 56m
Tue 9/2212:05 pm -
1 stop11h 46m
Deal found 8/7![LATAM Airlines logo]()
$669
This FlightHub deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1512:00 pm -
2 stops17h 00m
Tue 9/2912:05 pm -
1 stop11h 37m
Deal found 8/10![LATAM Airlines logo]()
$685
This FlightHub deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:30 pm -
1 stop11h 30m
Wed 9/2312:05 pm -
1 stop11h 46m
Deal found 8/5![LATAM Airlines logo]()
$679
This Expedia deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/162:40 pm -
2 stops46h 30m
Tue 9/291:15 pm -
2 stops24h 45m
Deal found 8/5![Multiple Airlines logo]()
$684
This United Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/168:35 am -
1 stop12h 35m
Mon 9/289:45 am -
1 stop12h 45m
Deal found 8/5![United Airlines logo]()
$699
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/165:00 am -
1 stop15h 15m
Tue 9/296:00 am -
2 stops15h 24m
Deal found 8/5![American Airlines logo]()
$704
This LATAM Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1610:05 am -
2 stops19h 00m
Mon 9/288:05 pm -
2 stops21h 35m
Deal found 8/8![LATAM Airlines logo]()
$721
This CheapOair deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/178:55 am -
2 stops23h 50m
Wed 9/308:50 pm -
2 stops23h 10m
Deal found 8/5![Multiple Airlines logo]()
$696
This American Airlines deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:30 am -
2 stops13h 45m
Tue 9/296:00 am -
2 stops15h 17m
Deal found 8/5![American Airlines logo]()
$720
This United Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/228:30 am -
1 stop12h 40m
Tue 9/299:45 am -
1 stop12h 50m
Deal found 8/8![United Airlines logo]()
$707
One-way flights from Missouri to South AmericaSearch for one-way flight options from Missouri to South America. Find affordable one-way fares based on user searches. Data last updated August 10, 2026.
Search for one-way flight options from Missouri to South America. Find affordable one-way fares based on user searches. Data last updated August 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/302:29 pm -
2 stops41h 46m
Deal found 8/5![Multiple Airlines logo]()
$211
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/52:29 pm -
3 stops34h 21m
Deal found 8/8![Multiple Airlines logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/286:17 pm -
3 stops53h 53m
Deal found 8/5![Multiple Airlines logo]()
$275
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:17 pm -
3 stops34h 44m
Deal found 8/5![Multiple Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1010:35 am -
3 stops41h 00m
Deal found 8/8![Multiple Airlines logo]()
$318
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2210:35 am -
3 stops39h 15m
Deal found 8/9![Multiple Airlines logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/255:27 pm -
3 stops35h 34m
Deal found 8/5![Multiple Airlines logo]()
$343
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1910:35 am -
3 stops38h 15m
Deal found 8/9![Multiple Airlines logo]()
$346
This Avianca deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/266:40 pm -
2 stops13h 05m
Deal found 8/6![Multiple Airlines logo]()
$348
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:58 pm -
3 stops33h 03m
Deal found 8/5![Multiple Airlines logo]()
$353
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2310:35 am -
3 stops59h 35m
Deal found 8/9![Multiple Airlines logo]()
$355
This Kiwi.com deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/252:29 pm -
3 stops32h 01m
Deal found 8/9![Multiple Airlines logo]()
$381
Find flight deals from Missouri to South America
Keep the following information in mind while searching for Missouri to South America flight deals. Data was last updated August 10, 2026.
Round-trip from | $632 (Expedia) |
|---|---|
One-way from | $211 (Kiwi.com) |
Popular in | January |
Cheapest in | September |
Average price | $589 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 10, 2026.
Use the filters below to find and compare flights from Missouri to South America that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisLima
STL Lambert-St Louis - LIM Lima J Chavez Intl
STLLIM
Lambert-St Louis
Sat 11/28
4:05 pm-6:10 am
1 stop13h 05m
Lima J Chavez Intl
Sat 12/5
8:00 am-3:26 pm
2 stops32h 26m
$680
Kansas CityLima
MCI Kansas City - LIM Lima J Chavez Intl
MCILIM
Kansas City
Tue 9/15
5:44 am-9:40 pm
2 stops15h 56m
Lima J Chavez Intl
Mon 9/21
12:15 am-7:00 pm
2 stops18h 45m
$683
St. LouisLima
STL Lambert-St Louis - LIM Lima J Chavez Intl
STLLIM
Lambert-St Louis
Tue 9/15
12:00 pm-5:00 am
2 stops17h 00m
Lima J Chavez Intl
Tue 9/29
12:05 pm-11:42 pm
1 stop11h 37m
$685
St. LouisMedellín
STL Lambert-St Louis - MDE Medellín Jose Maria Cordova Intl
STLMDE
Lambert-St Louis
Wed 10/14
6:15 am-9:10 pm
1 stop14h 55m
Medellín Jose Maria Cordova Intl
Tue 10/27
9:45 am-10:26 pm
1 stop12h 41m
$690
St. LouisMedellín
STL Lambert-St Louis - MDE Medellín Jose Maria Cordova Intl
STLMDE
Lambert-St Louis
Thu 10/22
6:15 am-9:10 pm
1 stop14h 55m
Medellín Jose Maria Cordova Intl
Wed 11/4
10:40 am-6:38 pm
1 stop8h 58m
$690
St. LouisMedellín
STL Lambert-St Louis - MDE Medellín Jose Maria Cordova Intl
STLMDE
Lambert-St Louis
Wed 9/16
8:35 am-9:10 pm
1 stop12h 35m
Medellín Jose Maria Cordova Intl
Mon 9/28
9:45 am-10:30 pm
1 stop12h 45m
$699
Kansas CityMedellín
MCI Kansas City - MDE Medellín Jose Maria Cordova Intl
MCIMDE
Kansas City
Tue 9/22
8:30 am-9:10 pm
1 stop12h 40m
Medellín Jose Maria Cordova Intl
Tue 9/29
9:45 am-10:35 pm
1 stop12h 50m
$707
St. LouisMedellín
STL Lambert-St Louis - MDE Medellín Jose Maria Cordova Intl
STLMDE
Lambert-St Louis
Fri 10/16
6:07 pm-12:48 pm
1 stop18h 41m
Medellín Jose Maria Cordova Intl
Wed 10/28
6:00 am-7:18 pm
2 stops13h 18m
$709
St. LouisMedellín
STL Lambert-St Louis - MDE Medellín Jose Maria Cordova Intl
STLMDE
Lambert-St Louis
Thu 10/1
6:15 am-9:10 pm
1 stop14h 55m
Medellín Jose Maria Cordova Intl
Tue 10/6
9:45 am-2:10 pm
1 stop28h 25m
$725
St. LouisMedellín
STL Lambert-St Louis - MDE Medellín Jose Maria Cordova Intl
STLMDE
Lambert-St Louis
Fri 8/28
2:40 pm-1:10 pm
2 stops22h 30m
Medellín Jose Maria Cordova Intl
Tue 9/1
2:10 pm-9:39 am
2 stops19h 29m
$732
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Missouri to South America
Have a flexible travel schedule? Discover the best time to fly to South America from Missouri with our price prediction graph.
STL-MDE
MCI-LIM
STL-LIM
MCI-MDE
MCI-GIG
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to South America
USMO-0SA
STL-MDE
MCI-LIM
STL-LIM
MCI-MDE
What is the cheapest month to book a flight from Missouri to South America?
Currently, April is the cheapest month in which you can book a flight from Missouri to South America (average of $834). Flying from Missouri to South America in December is currently the most expensive (average of $1,128). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How far ahead should I book a flight from Missouri to South America?
Booking 30 days in advance of your planned departure date is, on average, the best time to get cheap flights from Missouri to South America. The general trend is that the closer you book to the departure date, the more expensive your flight will be.
Related info for your journey
Find useful and relevant information for your journey from Missouri to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Missouri to South America
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South America by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to South America by cabin class
Find flights from Missouri to South America, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and South America flights
Browse other Missouri and South America flight options. Last updated on August 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South America
Find the right flight back to Missouri after your stay in South America
Fly to South America countries
Consider these flights traveling to countries located in South America.
Missouri to South America flights
Consider these flights traveling from Missouri to South America.
Top 5 airlines flying from Missouri to South America
Discover the top 5 airlines that operate flights from Missouri to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$536 | Average$867 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$562 | Average$954 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$563 | Average$988 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$615 | Average$921 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$801 | Average$1,005 | FlexibilityNo cancel fee | On-time74% |