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South America

$109+ Cheap flights from Indianapolis (IND) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/10. Fares are subject to change and may not be available on all flights or dates of travel.
IND — BOG
Nov 28 — Dec 51
Fri 11/28
Fri 12/5
1 adult, Economy
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Cheap flight deals from Indianapolis to South America

Keep the following information in mind while searching for Indianapolis to South America flight deals. Data was last updated October 29, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$314
(Cheapflightsfares)

One-way from

$109
(Priceline)

Popular in

December

Cheapest in

May

Average price

$1,078
Provider with most accurate pricing for Indianapolis-Sao Paulo (SAO) flight deals.
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Provider most trusted by Cheapflights users for Indianapolis-Sao Paulo (SAO) flights.
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From Indianapolis to South America
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One-way flight from Indianapolis to South America
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Highest demand for flights based on searches. 11% potential increase in price ($130 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($38 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Indianapolis to South America

Cheapest flights from Indianapolis to South America
Explore the most affordable flight options available from Indianapolis to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 29, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/297:00 amIND - MDE
1 stop17h 56mSpirit Airlines
Sat 1/313:11 pmMDE - IND
1 stop7h 45mSpirit Airlines
Deal found 10/27$314
This Orbitz deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/138:59 pmIND - BOG
1 stop16h 01mSpirit Airlines
Fri 11/143:15 pmBOG - IND
1 stop9h 36mSpirit Airlines
Deal found 10/29$327
This KAYAK deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/27:00 amIND - CTG
1 stop6h 25mSpirit Airlines
Sat 12/62:15 pmCTG - IND
1 stop21h 18mSpirit Airlines
Deal found 10/28$331
This KAYAK deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/157:00 amIND - CTG
1 stop6h 15mSpirit Airlines
Thu 11/202:30 pmCTG - IND
1 stop8h 49mSpirit Airlines
Deal found 10/29$336
This Cheapflightsfares deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/277:00 amIND - CTG
1 stop6h 25mSpirit Airlines
Tue 12/22:30 pmCTG - IND
1 stop8h 49mSpirit Airlines
Deal found 10/26$358
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/289:32 amIND - BOG
1 stop27h 28mMultiple Airlines
Fri 12/51:47 pmBOG - IND
2 stops17h 56mMultiple Airlines
Deal found 10/29$366
This KAYAK deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/289:03 amIND - BOG
1 stop27h 57mSpirit Airlines
Thu 12/42:17 amBOG - IND
1 stop8h 41mSpirit Airlines
Deal found 10/29$369
This KAYAK deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/267:00 amIND - CTG
1 stop6h 25mSpirit Airlines
Wed 12/32:30 pmCTG - IND
1 stop21h 03mSpirit Airlines
Deal found 10/28$383
This KAYAK deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/55:30 amIND - MDE
1 stop29h 25mSpirit Airlines
Mon 12/82:05 amMDE - IND
1 stop8h 53mSpirit Airlines
Deal found 10/29$384
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/155:24 pmIND - BOG
1 stop19h 28mMultiple Airlines
Wed 1/281:57 pmBOG - IND
1 stop23h 00mMultiple Airlines
Deal found 10/27$399
This Orbitz deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1312:38 pmIND - MDE
1 stop12h 31mSpirit Airlines
Fri 12/192:25 amMDE - IND
1 stop9h 08mSpirit Airlines
Deal found 10/27$404
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/27:00 amIND - CTG
1 stop6h 25mMultiple Airlines
Sat 12/66:50 amCTG - IND
3 stops28h 08mMultiple Airlines
Deal found 10/28$405

Cheapflights Fare Finder

 
Customize your flight search to find flights from Indianapolis to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
Use the filters below to find and compare flights from Indianapolis to South America that are best for you.

Fly from

Indianapolis

Fly to

South America

Route

Depart

Return

Price

IndianapolisMedellín

IND - MDE

INDMDE

Indianapolis

Sat 11/29

7:00 am-12:56 am

1 stop17h 56m

Medellín Jose Maria Cordova Intl

Fri 1/30

1:51 am-3:42 pm

1 stop13h 51m

$314

IndianapolisMedellín

IND - MDE

INDMDE

Indianapolis

Mon 1/5

12:38 pm-1:28 am

1 stop12h 50m

Medellín Jose Maria Cordova Intl

Wed 1/21

1:51 am-3:42 pm

1 stop13h 51m

$331

IndianapolisCartagena

IND - CTG

INDCTG

Indianapolis

Sat 11/15

7:00 am-1:15 pm

1 stop6h 15m

Cartagena Rafael Nunez

Thu 11/20

2:30 pm-11:19 pm

1 stop8h 49m

$336

IndianapolisCartagena

IND - CTG

INDCTG

Indianapolis

Fri 1/23

6:35 am-1:08 pm

1 stop6h 33m

Cartagena Rafael Nunez

Fri 1/30

2:16 pm-10:56 pm

1 stop8h 40m

$341

IndianapolisCartagena

IND - CTG

INDCTG

Indianapolis

Fri 1/9

6:35 am-1:08 pm

1 stop6h 33m

Cartagena Rafael Nunez

Tue 1/13

2:16 pm-10:56 pm

1 stop8h 40m

$354

IndianapolisMedellín

IND - MDE

INDMDE

Indianapolis

Tue 1/6

12:38 pm-1:28 am

1 stop12h 50m

Medellín Jose Maria Cordova Intl

Wed 1/21

1:51 am-12:57 pm

2 stops11h 06m

$355

IndianapolisCartagena

IND - CTG

INDCTG

Indianapolis

Thu 11/27

7:00 am-1:25 pm

1 stop6h 25m

Cartagena Rafael Nunez

Tue 12/2

2:30 pm-11:19 pm

1 stop8h 49m

$358

IndianapolisCartagena

IND - CTG

INDCTG

Indianapolis

Thu 1/8

6:35 am-1:08 pm

1 stop6h 33m

Cartagena Rafael Nunez

Mon 1/12

2:16 pm-10:56 pm

1 stop8h 40m

$382

IndianapolisBogotá

IND - BOG

INDBOG

Indianapolis

Thu 11/13

7:00 am-2:10 pm

1 stop7h 10m

Bogotá El Dorado

Fri 11/14

1:55 pm-12:51 am

2 stops10h 56m

$382

IndianapolisMedellín

IND - MDE

INDMDE

Indianapolis

Fri 12/5

5:30 am-10:55 am

1 stop29h 25m

Medellín Jose Maria Cordova Intl

Mon 12/8

2:05 am-10:58 am

1 stop8h 53m

$384

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Showing 1-10 of 60 results
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Best time to book a flight from Indianapolis to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Indianapolis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Indianapolis to South America

What is the cheapest month to book a flight from Indianapolis to South America?

Currently, October is the cheapest month in which you can book a flight from Indianapolis to South America (average of $129). Flying from Indianapolis to South America in March is currently the most expensive (average of $470). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IND to SA?

Find hourly flight availability from Indianapolis to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 29, 2025.

One of the essential ways to save on airfare from Indianapolis to South America is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the evening could potentially save you up to 11% on airfare.

What is the cheapest day to fly from Indianapolis to South America?

Use this chart to determine the cheapest time to fly round-trip from Indianapolis to South America. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Indianapolis to South America flight should consider departing on Saturday evenings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated October 29, 2025.
See what other customers who have flown with Delta, LATAM Airlines, and United Airlines from Indianapolis to South America have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,993 reviews

Overall

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
7.9
Good
7,993 reviews
Delta
7.9
Good
7,993 reviews

Overall

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
LATAM Airlines
7.5
Good
1,871 reviews
Delta
7.9
Good
7,993 reviews

Overall

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
United Airlines
7.4
Good
9,001 reviews
Delta
7.9
Good
7,993 reviews

Overall

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,993 reviews

Overall

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Spirit Airlines
6.3
Okay
8,114 reviews
Delta
7.9
Good
7,993 reviews

Overall

7.9

Boarding

8.2

Comfort

7.9

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Indianapolis to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Indianapolis to South America?

    If you book a flight to South America from Indianapolis, you will be flying from Indianapolis, which is the city’s only airport. Indianapolis (IND) is located 8.3 mi from the center of Indianapolis.

  • How long is the flight from Indianapolis to South America?

    Spirit Airlines, United Airlines, and LATAM Airlines can get you from Indianapolis to South America in just under 15h 58m. Your travel time can differ by up to 1h 58m. There are 5144 mi between Indianapolis and South America. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from Indianapolis to South America?

    The most popular flight routes from Indianapolis to South America are Indianapolis - Bogotá El Dorado, Indianapolis - Lima J Chavez Intl and Indianapolis - Cartagena Rafael Nunez.

  • Can I find deals for flights from Indianapolis to South America that include hotel bookings?

    Yes. In addition to deals on Indianapolis to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indianapolis to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indianapolis to South America.

  • Can I find deals for business class flights from Indianapolis to South America?

    Yes. Cheapflights offers flight deals from Indianapolis to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indianapolis to South America?

    Currently, October is the cheapest month in which you can book a flight from Indianapolis to South America (average of $129). Flying from Indianapolis to South America in March is currently the most expensive (average of $470). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Indianapolis to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Indianapolis to South America

Discover the top 6 airlines that operate flights from Indianapolis to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$278Average$624FlexibilityNo cancel feeOn-time65%
Copa AirlinesCheapest$420Average$659FlexibilityNo cancel feeOn-time70%
LATAM AirlinesCheapest$426Average$1,123FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$528Average$1,008FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$538Average$891FlexibilityNo cancel feeOn-time69%
DeltaCheapest$543Average$929FlexibilityNo cancel feeOn-timeN/A

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