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South America

$127+ Cheap flights from Buffalo (BUF) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/9. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — BOG
Feb 26 — Mar 51
Thu 2/26
Thu 3/5
1 adult, Economy
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Find cheap flights from Buffalo to South America with Cheapflights

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Cheap flight deals from Buffalo to South America

Cheapest flights from Buffalo to South America
Explore the most affordable flight options available from Buffalo to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 27, 2026.

This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/237:41 pm
BUF
-
MDE
2 stops18h 25m
American Airlines
Wed 2/253:10 pm
MDE
-
BUF
2 stops20h 33m
American Airlines
Deal found 1/26$265
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/207:21 pm
BUF
-
MDE
2 stops26h 44m
United Airlines
Wed 2/2510:45 am
MDE
-
BUF
2 stops34h 06m
United Airlines
Deal found 1/26$324
This Trip.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/236:00 am
BUF
-
CTG
1 stop8h 40m
JetBlue
Fri 3/62:35 pm
CTG
-
BUF
1 stop9h 03m
JetBlue
Deal found 1/25$329
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/235:24 pm
BUF
-
MDE
2 stops28h 41m
United Airlines
Mon 3/210:45 am
MDE
-
BUF
2 stops34h 06m
United Airlines
Deal found 1/27$330
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/29:55 am
BUF
-
MDE
2 stops36h 10m
United Airlines
Thu 2/510:45 am
MDE
-
BUF
2 stops33h 44m
United Airlines
Deal found 1/26$337
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/316:00 am
BUF
-
MDE
2 stops16h 05m
United Airlines
Sat 2/1410:45 am
MDE
-
BUF
2 stops37h 14m
United Airlines
Deal found 1/26$339
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/235:29 pm
BUF
-
CTG
2 stops20h 01m
American Airlines
Fri 3/64:30 pm
CTG
-
BUF
2 stops23h 24m
American Airlines
Deal found 1/27$342
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/3111:24 am
BUF
-
MDE
2 stops34h 41m
United Airlines
Sat 2/710:45 am
MDE
-
BUF
2 stops33h 44m
United Airlines
Deal found 1/26$345
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/25:23 pm
BUF
-
MDE
2 stops28h 42m
United Airlines
Sat 2/1410:45 am
MDE
-
BUF
2 stops34h 06m
United Airlines
Deal found 1/26$364
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/106:00 am
BUF
-
CTG
1 stop8h 15m
Delta
Thu 3/262:30 pm
CTG
-
BUF
1 stop8h 16m
Delta
Deal found 1/26$379
This JetBlue deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/237:00 am
BUF
-
MDE
1 stop7h 45m
JetBlue
Wed 2/252:25 pm
MDE
-
BUF
1 stop9h 08m
JetBlue
Deal found 1/25$380
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:40 pm
BUF
-
CTG
2 stops17h 45m
American Airlines
Tue 8/253:10 pm
CTG
-
BUF
2 stops18h 44m
American Airlines
Deal found 1/25$384

Find flight deals from Buffalo to South America

Keep the following information in mind while searching for Buffalo to South America flight deals. Data was last updated January 27, 2026.

Round-trip from

$265
(American Airlines)

One-way from

$127
(Kiwi.com)

Popular in

June

Cheapest in

December
From Buffalo to South America
Search Deals
One-way flight from Buffalo to South America
Search Deals
Highest demand for flights based on searches. 21% potential increase in price ($156 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($25 potential savings vs. average RT price).
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from Buffalo to South America that are best for you.

Fly from

Buffalo

Fly to

South America

Route

Depart

Return

Price

BuffaloMedellín

BUF - MDE

BUFMDE

Buffalo

Mon 2/23

7:41 pm-2:06 pm

2 stops18h 25m

Medellín Jose Maria Cordova Intl

Wed 2/25

3:10 pm-12:51 pm

2 stops21h 41m

$265

BuffaloMedellín

BUF - MDE

BUFMDE

Buffalo

Fri 2/20

7:21 pm-10:05 pm

2 stops26h 44m

Medellín Jose Maria Cordova Intl

Wed 2/25

10:45 am-8:51 pm

2 stops34h 06m

$324

BuffaloCartagena

BUF - CTG

BUFCTG

Buffalo

Mon 2/23

6:00 am-2:40 pm

1 stop8h 40m

Cartagena Rafael Nunez

Fri 3/6

2:35 pm-11:38 pm

1 stop9h 03m

$329

BuffaloMedellín

BUF - MDE

BUFMDE

Buffalo

Mon 2/23

5:24 pm-10:05 pm

2 stops28h 41m

Medellín Jose Maria Cordova Intl

Mon 3/2

10:45 am-8:51 pm

2 stops34h 06m

$330

BuffaloMedellín

BUF - MDE

BUFMDE

Buffalo

Thu 2/26

7:00 am-10:05 pm

2 stops39h 05m

Medellín Jose Maria Cordova Intl

Mon 3/2

10:45 am-8:51 pm

2 stops34h 06m

$330

BuffaloCartagena

BUF - CTG

BUFCTG

Buffalo

Mon 2/23

4:04 pm-1:30 pm

2 stops21h 26m

Cartagena Rafael Nunez

Fri 3/6

4:30 pm-12:55 pm

2 stops20h 25m

$342

BuffaloCartagena

BUF - CTG

BUFCTG

Buffalo

Sat 2/21

7:51 pm-3:30 pm

2 stops19h 39m

Cartagena Rafael Nunez

Tue 2/24

2:30 pm-11:43 am

2 stops21h 13m

$342

BuffaloMedellín

BUF - MDE

BUFMDE

Buffalo

Fri 2/6

8:30 am-10:05 pm

2 stops37h 35m

Medellín Jose Maria Cordova Intl

Sat 2/14

10:45 am-8:51 pm

2 stops34h 06m

$364

BuffaloCartagena

BUF - CTG

BUFCTG

Buffalo

Tue 3/10

6:00 am-1:15 pm

1 stop8h 15m

Cartagena Rafael Nunez

Thu 3/26

2:30 pm-11:46 pm

1 stop8h 16m

$379

BuffaloCartagena

BUF - CTG

BUFCTG

Buffalo

Tue 3/10

5:59 pm-2:15 pm

2 stops21h 16m

Cartagena Rafael Nunez

Thu 3/26

1:28 pm-10:58 am

2 stops20h 30m

$385

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 60 results
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Best time to book a flight from Buffalo to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to South America

What is the cheapest month to book a flight from Buffalo to South America?

Currently, December is the cheapest month in which you can book a flight from Buffalo to South America (average of $152). Flying from Buffalo to South America in October is currently the most expensive (average of $521). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated January 27, 2026.
Get a feel of what it's like to fly with Delta and LATAM Airlines from Buffalo to South America by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,119 reviews

Entertainment

7.8

Crew

8.5

Food

7.2

Overall

7.9

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
Delta
7.9
Good
8,119 reviews
Delta
7.9
Good
8,119 reviews

Entertainment

7.8

Crew

8.5

Food

7.2

Overall

7.9

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.
LATAM Airlines
7.5
Good
1,912 reviews
Delta
7.9
Good
8,119 reviews

Entertainment

7.8

Crew

8.5

Food

7.2

Overall

7.9

Comfort

7.9

Boarding

8.1

Reviews

1 / 20
10.0
Excellent

Kymberlee,Oct 2024

JFK - ATL

Overall it was good on the flight. Before the flight with checking the bag at JFK was a nightmare. It took way too long and the Delta concierge was very rude to everyone. But other than that it was fine.

Related info for your journey

Find useful and relevant information for your journey from Buffalo to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Buffalo to South America?

    Buffalo (BUF) is the airport you will fly out of if you book a flight from Buffalo to South America. It is only a 8.3 mi journey to Buffalo (BUF) from Buffalo’s city center.

  • How long is the flight from Buffalo to South America?

    Departing from Buffalo to South America will take you 8h 40m. Buffalo and South America are separated by a distance of 2252 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Buffalo to South America one-way?

    The cheapest airline one-way is JetBlue, with whom users have recently found tickets for as low as $241. However, be on the lookout for offers from Avianca and LATAM Airlines, as they are both options that can get you from Buffalo to South America for a low price.

  • What are the most popular routes from Buffalo to South America?

    While some choose either Buffalo - Buenos Aires Jorge Newbery or Buffalo - Buenos Aires Ministro Pistarini, Buffalo - Cartagena Rafael Nunez is the most popular route from Buffalo to South America.

  • Can I find deals for flights from Buffalo to South America that include hotel bookings?

    Yes. In addition to deals on Buffalo to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to South America.

  • Can I find deals for business class flights from Buffalo to South America?

    Yes. Cheapflights offers flight deals from Buffalo to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Buffalo to South America?

    Currently, December is the cheapest month in which you can book a flight from Buffalo to South America (average of $152). Flying from Buffalo to South America in October is currently the most expensive (average of $521). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Buffalo to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Buffalo to South America

Discover the top 2 airlines that operate flights from Buffalo to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$320Average$689FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$494Average$776FlexibilityNo cancel feeOn-time81%

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