How long is the flight from Missouri to Santiago?

Departing from Missouri to Santiago will take you 18h 44m. Airlines will cover a distance of 5137 mi. Both multi-stop and nonstop flights can be found to your destination and back.

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 2.8 inches per month. June is typically the wettest month, when rainfall can reach 2.8 in. January is typically the driest time to visit Santiago when rainfall is around 0.0 in.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 46.4 F).

What are the most popular routes from Missouri to Santiago?

While some choose either Lambert-St Louis - Santiago Arturo Merino Benitez or Springfield-Branson - Santiago Arturo Merino Benitez, Kansas City - Santiago Arturo Merino Benitez is the most popular route from Missouri to Santiago.

What are the most popular airlines that fly from Missouri to Santiago?

The most popular airlines flying from Missouri to Santiago are Delta, American Airlines and LATAM Airlines. Something to consider prior to booking your flight.

What is the cheapest time of day to fly from MO to SCL?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Santiago as you normally would.

What airport do you fly into for flights to Santiago from Missouri?

Santiago Arturo Merino Benitez (SCL), located 8.4 mi from the city center, is the airport you fly into when you book flights from Missouri to Santiago.

Can I find deals for flights from Missouri to Santiago that include hotel bookings?

Yes. In addition to deals on Missouri to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Missouri to Santiago?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Santiago.

Can I find deals for business class flights from Missouri to Santiago?

Yes. Cheapflights offers flight deals from Missouri to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$330+ Flights from Missouri to Santiago

Q: How much does it cost to fly round-trip from Missouri to Santiago?

Airfare is below average for this route at the moment. Missouri to Santiago flights typically cost between $922 and $1,647 in March. The cheapest round-trip price found within the last 3 days was $743 on LATAM Airlines (Mar 11-Mar 23).

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Cheap flight deals from Missouri to Santiago

Cheapest flights from Missouri to Santiago
Explore the most affordable flight options available from Missouri to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 29, 2025.

Mon 12/293:30 pmSTL - SCL

1 stop13h 15mAmerican Airlines

Mon 1/510:25 pmSCL - STL

1 stop13h 43mAmerican Airlines

Deal found 12/28

$1,635

Sun 12/2811:41 amSTL - SCL

1 stop17h 04mAmerican Airlines

Mon 1/510:25 pmSCL - STL

1 stop13h 43mAmerican Airlines

Deal found 12/28

$1,675

Mon 12/296:00 amSTL - SCL

3 stops29h 30mLATAM Airlines

Mon 1/510:15 pmSCL - STL

2 stops39h 50mLATAM Airlines

Deal found 12/28

$1,843

Sun 12/285:02 pmSTL - SCL

2 stops36h 48mUnited Airlines

Mon 1/510:45 pmSCL - STL

2 stops21h 58mUnited Airlines

Deal found 12/28

$1,866

Sun 12/284:05 pmSTL - SCL

2 stops59h 45mMultiple Airlines

Mon 1/58:15 amSCL - STL

3 stops29h 50mMultiple Airlines

Deal found 12/28

$2,417

Best flights from Missouri to Santiago
Discover carefully curated flight deals from Missouri to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 29, 2025.

Wed 3/115:21 pmSTL - SCL

2 stops18h 44mLATAM Airlines

Mon 3/2311:25 pmSCL - STL

2 stops20h 28mLATAM Airlines

Deal found 12/28

$743

Wed 3/116:00 amSTL - SCL

1 stop23h 50mUnited Airlines

Mon 3/239:45 pmSCL - STL

1 stop13h 36mUnited Airlines

Deal found 12/28

$755

Wed 1/146:00 amSGF - SCL

1 stop22h 40mDelta

Wed 1/286:30 pmSCL - SGF

2 stops24h 45mDelta

Deal found 12/27

$764

Wed 1/1410:50 amSGF - SCL

1 stop18h 25mAmerican Airlines

Wed 1/2810:30 pmSCL - SGF

1 stop16h 44mAmerican Airlines

Deal found 12/27

$764

Thu 2/1912:00 pmSGF - SCL

2 stops32h 25mLATAM Airlines

Mon 2/234:20 pmSCL - SGF

2 stops27h 27mLATAM Airlines

Deal found 12/26

$764

Tue 2/105:04 pmSTL - SCL

2 stops19h 26mDelta

Tue 2/178:15 amSCL - STL

2 stops18h 21mDelta

Deal found 12/27

$764

Tue 2/1010:07 amSTL - SCL

1 stop19h 43mUnited Airlines

Tue 2/1710:45 pmSCL - STL

1 stop13h 38mUnited Airlines

Deal found 12/27

$764

Wed 1/146:00 amSGF - SCL

1 stop22h 40mLATAM Airlines

Wed 1/286:30 pmSCL - SGF

2 stops19h 50mLATAM Airlines

Deal found 12/28

$764

Wed 3/1112:04 pmSTL - SCL

1 stop17h 36mDelta

Mon 3/2310:10 pmSCL - STL

1 stop14h 59mDelta

Deal found 12/28

$764

Thu 2/124:03 pmMCI - SCL

1 stop13h 47mUnited Airlines

Thu 2/1910:45 pmSCL - MCI

1 stop16h 11mUnited Airlines

Deal found 12/28

$764

Sat 1/311:02 pmMCI - SCL

1 stop16h 13mAmerican Airlines

Fri 2/610:35 pmSCL - MCI

1 stop15h 33mAmerican Airlines

Deal found 12/27

$844

Tue 2/105:04 pmSTL - SCL

1 stop11h 36mLATAM Airlines

Tue 2/176:40 amSCL - STL

2 stops19h 56mLATAM Airlines

Deal found 12/27

$764

Tue 2/1010:44 amMCI - SCL

1 stop17h 56mDelta

Tue 2/178:15 amSCL - MCI

2 stops18h 25mDelta

Deal found 12/27

$764

Tue 2/108:05 amMCI - SCL

1 stop21h 45mUnited Airlines

Tue 2/1710:45 pmSCL - MCI

1 stop16h 11mUnited Airlines

Deal found 12/27

$764

Tue 3/35:06 pmMCI - SCL

2 stops19h 24mLATAM Airlines

Mon 3/165:15 amSCL - MCI

2 stops20h 58mLATAM Airlines

Deal found 12/27

$764

Tue 3/39:59 amMCI - SCL

1 stop17h 56mDelta

Mon 3/1610:30 pmSCL - MCI

2 stops20h 25mDelta

Deal found 12/27

$769

Thu 2/193:08 pmSGF - SCL

1 stop14h 42mUnited Airlines

Mon 2/2310:45 pmSCL - SGF

2 stops26h 14mUnited Airlines

Deal found 12/26

$914

Sat 1/315:09 pmMCI - SCL

2 stops21h 46mLATAM Airlines

Fri 2/66:40 amSCL - MCI

2 stops20h 11mLATAM Airlines

Deal found 12/27

$844

Sat 1/315:09 pmMCI - SCL

2 stops17h 56mLATAM Airlines

Fri 3/611:10 pmSCL - MCI

1 stop15h 41mLATAM Airlines

Deal found 12/27

$844

Last-minute flights from Missouri to Santiago
Discover last-minute flight deals from Missouri to Santiago. Data last updated December 29, 2025 and is based on user searches.

Mon 1/57:10 amSTL - SCL

2 stops20h 35mMultiple Airlines

Tue 1/2011:10 pmSCL - STL

1 stop19h 57mMultiple Airlines

Deal found 12/27

$756

Mon 1/59:59 amSTL - SCL

1 stop17h 11mDelta

Tue 1/2011:10 pmSCL - STL

1 stop19h 57mDelta

Deal found 12/27

$764

Mon 1/511:05 amSTL - SCL

2 stops18h 45mAir Canada

Tue 1/2010:45 pmSCL - STL

2 stops16h 44mAir Canada

Deal found 12/27

$1,002

Wed 1/77:30 amMCI - SCL

2 stops20h 15mDelta

Wed 1/149:30 pmSCL - MCI

1 stop15h 46mDelta

Deal found 12/27

$927

Wed 1/75:50 amMCI - SCL

1 stop22h 50mLATAM Airlines

Wed 1/149:30 pmSCL - MCI

1 stop18h 14mLATAM Airlines

Deal found 12/28

$1,026

Wed 1/78:00 amMCI - SCL

2 stops21h 50mUnited Airlines

Wed 1/1410:45 pmSCL - MCI

2 stops26h 14mUnited Airlines

Deal found 12/28

$1,039

Sun 1/1111:26 amMCI - SCL

2 stops16h 14mMultiple Airlines

Wed 1/1411:24 amSCL - MCI

2 stops26h 07mMultiple Airlines

Deal found 12/28

$1,228

Wed 1/1412:01 pmSGF - SCL

2 stops24h 29mDelta

Wed 1/286:30 pmSCL - SGF

2 stops24h 45mDelta

Deal found 12/28

$764

Sat 1/249:59 amSTL - SCL

1 stop18h 41mLATAM Airlines

Fri 2/611:10 pmSCL - STL

1 stop23h 17mLATAM Airlines

Deal found 12/28

$836

Sun 1/256:30 pmMCI - SCL

2 stops35h 20mUnited Airlines

Thu 1/2910:45 pmSCL - MCI

1 stop18h 26mUnited Airlines

Deal found 12/27

$1,129

Sat 1/315:09 pmMCI - SCL

2 stops19h 21mDelta

Fri 3/611:10 pmSCL - MCI

1 stop19h 51mDelta

Deal found 12/27

$844

Sat 1/315:09 pmMCI - SCL

2 stops17h 56mLATAM Airlines

Fri 3/67:15 amSCL - MCI

3 stops19h 25mLATAM Airlines

Deal found 12/27

$849

One-way flights from Missouri to Santiago
Search for one-way flight options from Missouri to Santiago. Find affordable one-way fares based on user searches. Data last updated December 29, 2025.

Tue 1/275:42 pmSTL - SCL

2 stops33h 28mMultiple Airlines

Deal found 12/28

$330

Tue 1/274:05 pmSTL - SCL

1 stop17h 10mAir Canada

Deal found 12/28

$430

Find flight deals from Missouri to Santiago

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$743 (LATAM Airlines)
One-way from	$330 (Kiwi.com)
Popular in	February
Cheapest in	March
Average price	$944

Provider with most accurate pricing for Lambert-St Louis-Santiago Arturo Merino Benitez flight deals.

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Provider most trusted by Cheapflights users for Lambert-St Louis-Santiago Arturo Merino Benitez flights.

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From Missouri to Santiago Arturo Merino Benitez

Search Deals

One-way flight from Missouri to Santiago Arturo Merino Benitez

Search Deals

Highest demand for flights based on searches. 4% potential increase in price ($40 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 1% potential price decrease ($16 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Fly from

Fly to

Route

Depart

Return

Price

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

5:21 pm-2:05 pm

2 stops18h 44m

Santiago Arturo Merino Benitez

Mon 3/23

11:25 pm-5:53 pm

2 stops20h 28m

$743

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

6:00 am-7:50 am

1 stop23h 50m

Santiago Arturo Merino Benitez

Mon 3/23

9:45 pm-9:21 am

1 stop13h 36m

$755

SpringfieldSantiago

SGF - SCL

SGFSCL

Springfield-Branson

Wed 1/14

6:00 am-7:40 am

1 stop22h 40m

Santiago Arturo Merino Benitez

Wed 1/28

6:30 pm-4:15 pm

2 stops24h 45m

$764

SpringfieldSantiago

SGF - SCL

SGFSCL

Springfield-Branson

Wed 1/14

10:50 am-8:15 am

1 stop18h 25m

Santiago Arturo Merino Benitez

Wed 1/28

10:30 pm-12:14 pm

1 stop16h 44m

$764

SpringfieldSantiago

SGF - SCL

SGFSCL

Springfield-Branson

Thu 2/19

12:00 pm-11:25 pm

2 stops32h 25m

Santiago Arturo Merino Benitez

Mon 2/23

4:20 pm-4:47 pm

2 stops27h 27m

$764

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 2/10

5:04 pm-3:30 pm

2 stops19h 26m

Santiago Arturo Merino Benitez

Tue 2/17

8:15 am-11:36 pm

2 stops18h 21m

$764

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 2/10

10:07 am-8:50 am

1 stop19h 43m

Santiago Arturo Merino Benitez

Tue 2/17

10:45 pm-9:23 am

1 stop13h 38m

$764

SpringfieldSantiago

SGF - SCL

SGFSCL

Springfield-Branson

Wed 1/14

6:00 am-7:40 am

1 stop22h 40m

Santiago Arturo Merino Benitez

Wed 1/28

6:30 pm-11:20 am

2 stops19h 50m

$764

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Wed 3/11

12:04 pm-7:40 am

1 stop17h 36m

Santiago Arturo Merino Benitez

Mon 3/23

10:10 pm-11:09 am

1 stop14h 59m

$764

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

Thu 2/12

4:03 pm-8:50 am

1 stop13h 47m

Santiago Arturo Merino Benitez

Thu 2/19

10:45 pm-11:56 am

1 stop16h 11m

$764

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/28

Showing 1-10 of 21 results

Best time to book a flight from Missouri to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Missouri with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Santiago

What is the cheapest month to book a flight from Missouri to Santiago?

Currently, March is the cheapest month in which you can book a flight from Missouri to Santiago (average of $598). Flying from Missouri to Santiago in October is currently the most expensive (average of $924). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Missouri to Santiago?

Related info for your journey

What airport do you fly into for flights to Santiago from Missouri?
Santiago Arturo Merino Benitez (SCL), located 8.4 mi from the city center, is the airport you fly into when you book flights from Missouri to Santiago.
How long is the flight from Missouri to Santiago?
Departing from Missouri to Santiago will take you 18h 44m. Airlines will cover a distance of 5137 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the most popular routes from Missouri to Santiago?
While some choose either Lambert-St Louis - Santiago Arturo Merino Benitez or Springfield-Branson - Santiago Arturo Merino Benitez, Kansas City - Santiago Arturo Merino Benitez is the most popular route from Missouri to Santiago.
Can I find deals for flights from Missouri to Santiago that include hotel bookings?
Yes. In addition to deals on Missouri to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Missouri to Santiago?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Santiago.
Can I find deals for business class flights from Missouri to Santiago?
Yes. Cheapflights offers flight deals from Missouri to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Missouri to Santiago?
Currently, March is the cheapest month in which you can book a flight from Missouri to Santiago (average of $598). Flying from Missouri to Santiago in October is currently the most expensive (average of $924). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Missouri to Santiago

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$689	Average$970	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$755	Average$1,033	FlexibilityNo cancel fee	On-timeN/A
LATAM Airlines	Cheapest$823	Average$907	FlexibilityNo cancel fee	On-time81%

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$330+ Cheap flights from Missouri to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/27. Fares are subject to change and may not be available on all flights or dates of travel.

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Cheap flight deals from Missouri to Santiago

Cheapest flights from Missouri to SantiagoExplore the most affordable flight options available from Missouri to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 29, 2025.

Explore the most affordable flight options available from Missouri to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 29, 2025.

Find flight deals from Missouri to Santiago

Keep the following information in mind while searching for Missouri to Santiago flight deals. Data was last updated December 29, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from Missouri to Santiago that are best for you.

Best time to book a flight from Missouri to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Missouri with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Santiago

What is the cheapest month to book a flight from Missouri to Santiago?

How much does it cost to fly round-trip from Missouri to Santiago?

Related info for your journey

Find useful and relevant information for your journey from Missouri to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Santiago from Missouri?

How long is the flight from Missouri to Santiago?

What are the most popular routes from Missouri to Santiago?

Can I find deals for flights from Missouri to Santiago that include hotel bookings?

How can I find direct flights from Missouri to Santiago?

Can I find deals for business class flights from Missouri to Santiago?

What is the cheapest month to book a flight from Missouri to Santiago?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to Santiago

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Top 3 airlines flying from Missouri to Santiago

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Cheapest flights from Missouri to Santiago
Explore the most affordable flight options available from Missouri to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 29, 2025.