HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santiago

$326+ Cheap flights from Missouri to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/8. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Missouri to Santiago with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Missouri to Santiago

Keep the following information in mind while searching for Missouri to Santiago flight deals. Data was last updated June 12, 2025.

Round-trip from

$843
(SmartFares)

One-way from

$326
(Kiwi.com)

Popular in

September

Cheapest in

May

Average price

$1,356
From Missouri to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Missouri to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($239 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 9% potential price decrease ($96 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2025
Search Deals

Find flight deals from Missouri to Santiago

Cheapest flights from Missouri to Santiago
Explore the most affordable flight options available from Missouri to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This SmartFares deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/109:00 amSTL - SCL
1 stop19h 00mLATAM Airlines
Sun 11/232:30 pmSCL - STL
2 stops36h 09mLATAM Airlines
Deal found 6/11$843
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/102:40 pmSTL - SCL
2 stops15h 25mAmerican Airlines
Sun 11/2310:15 pmSCL - STL
2 stops16h 42mAmerican Airlines
Deal found 6/10$848
This LATAM Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/188:25 amSTL - SCL
3 stops32h 10mMultiple Airlines
Mon 8/253:40 pmSCL - STL
2 stops31h 22mMultiple Airlines
Deal found 6/11$874
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/38:00 amMCI - SCL
2 stops20h 40mDelta
Wed 9/105:55 pmSCL - MCI
2 stops21h 59mDelta
Deal found 6/11$874
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/13:30 pmSTL - SCL
1 stop13h 30mDelta
Fri 11/2112:30 amSCL - STL
2 stops20h 32mDelta
Deal found 6/10$884
This KAYAK deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/16:00 amMCI - SCL
3 stops23h 00mLATAM Airlines
Sat 11/2210:50 pmSCL - MCI
2 stops15h 38mLATAM Airlines
Deal found 6/11$898
This Mytrip deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/77:50 pmMCI - SCL
3 stops24h 25mMultiple Airlines
Mon 7/146:10 amSCL - MCI
3 stops34h 07mMultiple Airlines
Deal found 6/9$910
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/25:08 amMCI - SCL
1 stop24h 57mAmerican Airlines
Sat 8/99:55 pmSCL - MCI
1 stop27h 34mAmerican Airlines
Deal found 6/10$1,213
This Gotogate deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/278:15 amSTL - SCL
2 stops19h 49mCopa Airlines
Sat 8/212:12 amSCL - STL
2 stops19h 48mCopa Airlines
Deal found 6/12$1,453
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/199:30 amSGF - SCL
1 stop19h 20mAmerican Airlines
Sat 12/2711:15 pmSCL - SGF
1 stop13h 22mAmerican Airlines
Deal found 6/11$1,595
This KAYAK deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:00 amSGF - SCL
2 stops21h 40mLATAM Airlines
Sat 12/278:40 pmSCL - SGF
2 stops17h 07mLATAM Airlines
Deal found 6/11$1,669
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:00 amSGF - SCL
2 stops21h 40mDelta
Fri 12/2612:25 amSCL - SGF
2 stops24h 44mDelta
Deal found 6/11$1,792

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Missouri to Santiago that are best for you.

Fly from

Missouri

Fly to

Santiago

Route

Depart

Return

Price

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 11/10

9:00 am-7:00 am

1 stop19h 00m

Santiago Arturo Merino Benitez

Sun 11/23

2:30 pm-11:39 pm

2 stops36h 09m

$843

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 11/10

2:40 pm-9:05 am

2 stops15h 25m

Santiago Arturo Merino Benitez

Sun 11/23

10:15 pm-11:57 am

2 stops16h 42m

$848

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 8/18

8:25 am-5:35 pm

3 stops32h 10m

Santiago Arturo Merino Benitez

Mon 8/25

3:40 pm-10:02 pm

2 stops31h 22m

$874

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

Wed 9/3

6:59 am-7:00 am

1 stop23h 01m

Santiago Arturo Merino Benitez

Wed 9/10

9:40 pm-12:31 pm

1 stop16h 51m

$874

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sat 11/1

3:30 pm-7:00 am

1 stop13h 30m

Santiago Arturo Merino Benitez

Fri 11/21

12:30 am-6:02 pm

2 stops20h 32m

$884

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

Sat 11/1

6:00 am-7:00 am

3 stops23h 00m

Santiago Arturo Merino Benitez

Sat 11/22

10:50 pm-11:28 am

2 stops15h 38m

$898

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

Mon 7/7

7:50 pm-9:15 pm

3 stops24h 25m

Santiago Arturo Merino Benitez

Mon 7/14

6:10 am-3:17 pm

3 stops34h 07m

$910

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

Sat 8/2

5:08 am-7:05 am

1 stop24h 57m

Santiago Arturo Merino Benitez

Sat 8/9

9:55 pm-12:29 am

1 stop27h 34m

$1,213

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sun 7/27

8:15 am-5:04 am

2 stops19h 49m

Santiago Arturo Merino Benitez

Sat 8/2

12:12 am-7:00 pm

2 stops19h 48m

$1,453

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

Sat 8/2

8:00 am-5:04 am

2 stops20h 04m

Santiago Arturo Merino Benitez

Fri 8/8

12:12 am-7:46 pm

2 stops20h 34m

$2,901

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/11

Showing 1-10 of 18 results
1
2

Best time to book a flight from Missouri to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Santiago

What is the cheapest month to book a flight from Missouri to Santiago?

Currently, April is the cheapest month in which you can book a flight from Missouri to Santiago (average of $752). Flying from Missouri to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SCL?

Find hourly flight availability from Missouri to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Santiago as you normally would.

Rainfall in Santiago by month

Plan your trip to Santiago by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 2.8 inches per month. June is typically the wettest month, when rainfall can reach 2.8 in. January is typically the driest time to visit Santiago when rainfall is around 0.0 in.

Temperature in Santiago by month

Plan your trip to Santiago by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 46.4 F).

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated June 12, 2025.
To help decide which airline to fly from Missouri to Santiago, see what other customers have to say about Delta, LATAM Airlines and Qantas Airways. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,946 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,785 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Qantas Airways
7.5
Good
854 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Copa Airlines
7.5
Good
1,451 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Turkish Airlines
7.3
Good
3,848 reviews
Delta
8.0
Very good
7,946 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Food

7.3

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Missouri to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago from Missouri?

    Santiago Arturo Merino Benitez (SCL), located 8.4 mi from the city center, is the airport you fly into when you book flights from Missouri to Santiago.

  • What are the cheapest airlines to fly from Missouri to Santiago one-way?

    For one-way options, check prices for LATAM Airlines. According to our data, you can fly for as low as $537. Users have also found prices from $543 and $583 on Delta and American Airlines, respectively.

  • What are the most popular routes from Missouri to Santiago?

    While some choose either Kansas City - Santiago Arturo Merino Benitez or Joplin - Santiago Arturo Merino Benitez, Lambert-St Louis - Santiago Arturo Merino Benitez is the most popular route from Missouri to Santiago.

  • Can I find deals for flights from Missouri to Santiago that include hotel bookings?

    Yes. In addition to deals on Missouri to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Santiago.

  • Can I find deals for business class flights from Missouri to Santiago?

    Yes. Cheapflights offers flight deals from Missouri to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Missouri to Santiago (average of $752). Flying from Missouri to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Santiago flights
Miami to Santiago flights
Los Angeles to Santiago flights
Newark to Santiago flights
LaGuardia to Santiago flights
Dulles Intl to Santiago flights
Reagan-National to Santiago flights
San Francisco to Santiago flights
Baltimore to Santiago flights
Dallas/Fort Worth to Santiago flights
O'Hare Intl to Santiago flights
Atlanta to Santiago flights
Hobby to Santiago flights
Boston to Santiago flights
Denver to Santiago flights
Orlando to Santiago flights
George Bush Intcntl to Santiago flights
Tampa to Santiago flights
Seattle to Santiago flights
Midway to Santiago flights
Salt Lake City to Santiago flights
Fort Lauderdale to Santiago flights
Ontario to Santiago flights
Minneapolis to Santiago flights
Austin to Santiago flights
Sky Harbor Intl to Santiago flights
Love Field to Santiago flights
Sarasota to Santiago flights
Memphis to Santiago flights
Portland to Santiago flights
Nashville to Santiago flights
Knoxville to Santiago flights
Raleigh to Santiago flights
Philadelphia to Santiago flights
Detroit to Santiago flights
Charlotte to Santiago flights
Indianapolis to Santiago flights
Hartford to Santiago flights
Cincinnati to Santiago flights
Las Vegas to Santiago flights
John F Kennedy Intl to Punta Arenas flights
San Diego to Santiago flights
San Jose to Santiago flights
Greenville to Santiago flights
Milwaukee to Santiago flights
West Palm Beach to Santiago flights
Sacramento to Santiago flights
St. Louis to Santiago flights
Denver to Punta Arenas flights
New Orleans to Santiago flights

Top 4 airlines flying from Missouri to Santiago

Discover the top 4 airlines that operate flights from Missouri to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$742Average$1,029FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$762Average$986FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$807Average$1,027FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$883Average$1,002FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.