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$884+ Cheap flights from Missouri to Santiago (SCL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/1. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from Missouri to Santiago

Keep the following information in mind while searching for Missouri to Santiago flight deals. Data was last updated May 1, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$937
(Delta)

Popular in

September

Cheapest in

May

Average price

$858
Provider with most accurate pricing for Kansas City-Santiago Arturo Merino Benitez flight deals.
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Provider most trusted by Cheapflights users for Kansas City-Santiago Arturo Merino Benitez flights.
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From Missouri to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 20% potential increase in price ($295 potential increase over avg. RT price).
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Cheapest flight prices on average. 10% potential price decrease ($102 potential savings vs. average RT price).
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Average for round-trip flights in May 2025
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Find flight deals from Missouri to Santiago

Cheapest flights from Missouri to Santiago
Explore the most affordable flight options available from Missouri to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/111:51 amSTL - SCL
2 stops17h 09mDelta
Sat 11/227:55 amSCL - STL
2 stops18h 44mDelta
Deal found 4/30$884
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/110:35 amMCI - SCL
2 stops18h 25mDelta
Fri 11/2112:30 amSCL - MCI
2 stops20h 03mDelta
Deal found 4/30$884
This LATAM Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/16:00 amSTL - SCL
3 stops23h 00mLATAM Airlines
Sat 11/2210:25 amSCL - STL
2 stops16h 14mLATAM Airlines
Deal found 4/30$888
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/14:19 pmMCI - SCL
1 stop13h 31mAmerican Airlines
Sat 11/229:30 pmSCL - MCI
2 stops18h 50mAmerican Airlines
Deal found 4/30$888
This KAYAK deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/16:00 amMCI - SCL
3 stops23h 00mLATAM Airlines
Sat 11/225:15 amSCL - MCI
2 stops20h 06mLATAM Airlines
Deal found 4/30$898
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/168:35 amSTL - SCL
2 stops21h 30mAmerican Airlines
Sat 8/239:55 pmSCL - STL
2 stops18h 47mAmerican Airlines
Deal found 4/30$958
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/55:35 pmSTL - SCL
2 stops30h 15mMultiple Airlines
Thu 6/129:45 amSCL - STL
1 stop15h 08mMultiple Airlines
Deal found 4/30$1,019
This Air Canada deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/67:30 amSTL - SCL
2 stops28h 55mAir Canada
Thu 6/1211:55 pmSCL - STL
2 stops37h 41mAir Canada
Deal found 4/30$1,472
This Air Canada deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:00 amMCI - SCL
2 stops20h 00mAir Canada
Mon 1/58:50 pmSCL - MCI
2 stops23h 31mAir Canada
Deal found 4/30$1,942
This Copa Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/108:10 amSTL - SCL
2 stops19h 54mCopa Airlines
Wed 6/182:24 amSCL - STL
2 stops17h 58mCopa Airlines
Deal found 4/30$2,755
This Iberia deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/54:23 pmSTL - SCL
2 stops37h 57mIberia
Mon 6/94:15 pmSCL - STL
2 stops32h 39mIberia
Deal found 4/30$3,082

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Missouri to Santiago that are best for you.

Fly from

Missouri

Fly to

Santiago

Route

Depart

Return

Price

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sun 8/17

5:45 pm-6:30 am

2 stops35h 45m

Santiago Arturo Merino Benitez

Sun 8/24

11:05 pm-4:47 pm

2 stops18h 42m

$937

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sat 8/16

3:30 pm-7:00 am

1 stop14h 30m

Santiago Arturo Merino Benitez

Sun 8/24

8:40 pm-6:03 pm

1 stop22h 23m

$954

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Sat 8/16

8:35 am-7:05 am

2 stops21h 30m

Santiago Arturo Merino Benitez

Sat 8/23

9:55 pm-3:42 pm

2 stops18h 47m

$958

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

Tue 6/3

1:15 pm-7:00 am

1 stop16h 45m

Santiago Arturo Merino Benitez

Tue 6/17

11:00 am-9:30 am

2 stops23h 30m

$983

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 6/5

5:35 pm-12:50 am

2 stops30h 15m

Santiago Arturo Merino Benitez

Thu 6/12

9:45 am-11:53 pm

1 stop15h 08m

$1,019

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

Tue 6/3

7:00 am-7:00 am

1 stop23h 00m

Santiago Arturo Merino Benitez

Tue 6/17

8:40 pm-4:21 pm

1 stop20h 41m

$1,024

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Fri 6/6

7:30 am-1:25 pm

2 stops28h 55m

Santiago Arturo Merino Benitez

Thu 6/12

11:55 pm-12:36 pm

2 stops37h 41m

$1,472

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 6/10

8:10 am-5:04 am

2 stops19h 54m

Santiago Arturo Merino Benitez

Wed 6/18

2:24 am-7:22 pm

2 stops17h 58m

$2,755

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 6/5

4:23 pm-7:20 am

2 stops37h 57m

Santiago Arturo Merino Benitez

Mon 6/9

4:15 pm-11:54 pm

2 stops32h 39m

$3,082

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Best time to book a flight from Missouri to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Santiago

What is the cheapest month to book a flight from Missouri to Santiago?

Currently, April is the cheapest month in which you can book a flight from Missouri to Santiago (average of $752). Flying from Missouri to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SCL?

Find hourly flight availability from Missouri to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Santiago as you normally would.

Rainfall in Santiago by month

Plan your trip to Santiago by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Santiago ranges from 0.0 - 2.8 inches per month. June is typically the wettest month, when rainfall can reach 2.8 in. January is typically the driest time to visit Santiago when rainfall is around 0.0 in.

Temperature in Santiago by month

Plan your trip to Santiago by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Santiago, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 69.8 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 46.4 F).

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated May 1, 2025.
To help decide which airline to fly from Missouri to Santiago, see what other customers have to say about Delta, LATAM Airlines and Copa Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,934 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,767 reviews
Delta
8.0
Very good
7,934 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.5
Good
1,414 reviews
Delta
8.0
Very good
7,934 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,934 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Air Canada
7.0
Good
9,245 reviews
Delta
8.0
Very good
7,934 reviews

Food

7.3

Comfort

7.9

Crew

8.5

Entertainment

7.9

Overall

8.0

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago from Missouri?

    Santiago Arturo Merino Benitez (SCL), located 8.4 mi from the city center, is the airport you fly into when you book flights from Missouri to Santiago.

  • What are the most popular routes from Missouri to Santiago?

    While some choose either Kansas City - Santiago Arturo Merino Benitez or Joplin - Santiago Arturo Merino Benitez, Lambert-St Louis - Santiago Arturo Merino Benitez is the most popular route from Missouri to Santiago.

  • Can I find deals for flights from Missouri to Santiago that include hotel bookings?

    Yes. In addition to deals on Missouri to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Santiago.

  • Can I find deals for business class flights from Missouri to Santiago?

    Yes. Cheapflights offers flight deals from Missouri to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Missouri to Santiago (average of $752). Flying from Missouri to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Missouri to Santiago

Discover the top 4 airlines that operate flights from Missouri to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$742Average$1,029FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$762Average$1,126FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$807Average$1,003FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$883Average$1,002FlexibilityNo cancel feeOn-time69%

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