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$312+ Cheap flights from Missouri to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/25. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
Dec 14 — Dec 211
Sun 12/14
Sun 12/21
1 adult, Economy
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Cheap flight deals from Missouri to Santiago

Keep the following information in mind while searching for Missouri to Santiago flight deals. Data was last updated November 14, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$741
(LATAM Airlines)

One-way from

$312
(Kiwi.com)

Popular in

February

Cheapest in

March

Average price

$888
Provider with most accurate pricing for Lambert-St Louis-Santiago Arturo Merino Benitez flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Santiago Arturo Merino Benitez flights.
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From Missouri to Santiago Arturo Merino Benitez
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One-way flight from Missouri to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 2% potential increase in price ($25 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Missouri to Santiago

Cheapest flights from Missouri to Santiago
Explore the most affordable flight options available from Missouri to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 14, 2025.

This LATAM Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2711:04 amSTL - SCL
1 stop17h 36mLATAM Airlines
Mon 12/810:35 amSCL - STL
2 stops16h 07mLATAM Airlines
Deal found 11/12$753
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/204:35 pmMCI - SCL
1 stop13h 15mUnited Airlines
Mon 12/110:45 pmSCL - MCI
1 stop18h 32mUnited Airlines
Deal found 11/11$764
This United Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/47:50 amJLN - SCL
2 stops22h 00mUnited Airlines
Mon 12/810:45 pmSCL - JLN
2 stops27h 42mUnited Airlines
Deal found 11/10$769
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1111:40 amSTL - SCL
2 stops14h 55mDelta
Mon 12/1511:25 pmSCL - STL
2 stops16h 32mDelta
Deal found 11/11$769
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2010:20 amMCI - SCL
1 stop18h 20mDelta
Fri 11/2811:55 pmSCL - MCI
1 stop18h 00mDelta
Deal found 11/11$804
This United Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2211:36 amMCI - SCL
2 stops18h 14mUnited Airlines
Mon 12/110:45 pmSCL - MCI
2 stops18h 36mUnited Airlines
Deal found 11/11$809
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/227:05 amMCI - SCL
1 stop20h 25mDelta
Fri 11/2811:55 pmSCL - MCI
1 stop18h 00mDelta
Deal found 11/11$844
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/119:31 amMCI - SCL
1 stop19h 14mAmerican Airlines
Mon 1/1210:35 pmSCL - MCI
1 stop15h 25mAmerican Airlines
Deal found 11/12$870
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/115:50 amMCI - SCL
1 stop21h 20mDelta
Tue 1/138:15 amSCL - MCI
2 stops17h 36mDelta
Deal found 11/11$894
This American Airlines deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/119:31 amMCI - SCL
1 stop19h 14mAmerican Airlines
Tue 1/1310:30 pmSCL - MCI
1 stop27h 42mAmerican Airlines
Deal found 11/12$940
This LATAM Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/119:30 amSTL - SCL
2 stops18h 05mLATAM Airlines
Mon 12/157:15 amSCL - STL
3 stops19h 27mLATAM Airlines
Deal found 11/11$949
This eDestinos deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1112:47 pmMCI - SCL
1 stop15h 53mLATAM Airlines
Tue 1/1311:10 pmSCL - MCI
1 stop14h 10mLATAM Airlines
Deal found 11/11$989

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 14, 2025.
Use the filters below to find and compare flights from Missouri to Santiago that are best for you.

Fly from

Missouri

Fly to

Santiago

Route

Depart

Return

Price

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 11/27

3:15 pm-7:40 am

1 stop13h 25m

Santiago Arturo Merino Benitez

Mon 12/8

10:35 am-11:42 pm

2 stops16h 07m

$753

SpringfieldSantiago

SGF - SCL

SGFSCL

Springfield-Branson

Wed 1/14

12:02 pm-7:40 am

1 stop16h 38m

Santiago Arturo Merino Benitez

Wed 1/28

11:10 pm-11:22 am

1 stop15h 12m

$764

SpringfieldSantiago

SGF - SCL

SGFSCL

Springfield-Branson

Wed 1/14

5:05 pm-2:05 pm

2 stops18h 00m

Santiago Arturo Merino Benitez

Wed 1/28

6:30 pm-11:22 am

2 stops19h 52m

$764

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

Wed 1/7

4:00 pm-7:40 am

1 stop12h 40m

Santiago Arturo Merino Benitez

Wed 1/14

6:30 pm-12:44 pm

2 stops21h 14m

$764

JoplinSantiago

JLN - SCL

JLNSCL

Joplin

Thu 12/4

7:50 am-8:50 am

2 stops22h 00m

Santiago Arturo Merino Benitez

Mon 12/8

10:45 pm-11:27 pm

2 stops27h 42m

$769

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 12/11

9:30 am-5:35 am

2 stops17h 05m

Santiago Arturo Merino Benitez

Mon 12/15

9:30 pm-10:45 am

1 stop16h 15m

$769

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 12/11

11:40 am-5:35 am

2 stops14h 55m

Santiago Arturo Merino Benitez

Mon 12/15

9:30 pm-10:45 am

1 stop16h 15m

$769

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 11/27

7:05 am-6:55 am

2 stops20h 50m

Santiago Arturo Merino Benitez

Mon 12/8

11:25 pm-1:04 pm

2 stops16h 39m

$769

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

Wed 1/7

1:55 pm-2:30 pm

3 stops21h 35m

Santiago Arturo Merino Benitez

Wed 1/14

1:40 pm-12:44 pm

2 stops26h 04m

$769

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

Sat 3/14

6:00 am-9:35 pm

3 stops61h 35m

Santiago Arturo Merino Benitez

Sat 3/21

10:25 pm-6:08 pm

2 stops45h 43m

$869

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/12

Showing 1-10 of 25 results
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Best time to book a flight from Missouri to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Santiago

What is the cheapest month to book a flight from Missouri to Santiago?

Currently, December is the cheapest month in which you can book a flight from Missouri to Santiago (average of $552). Flying from Missouri to Santiago in October is currently the most expensive (average of $924). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SCL?

Find hourly flight availability from Missouri to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 14, 2025.

A simple way to save on the total cost of your ticket is to fly from Missouri to Santiago in the evening. If you’re flexible enough to do this you can expect to save up to 20% on your trip compared to booking a flight at noon.

How much does it cost to fly round-trip from Missouri to Santiago?

Related info for your journey

Find useful and relevant information for your journey from Missouri to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago from Missouri?

    Santiago Arturo Merino Benitez (SCL), located 8.4 mi from the city center, is the airport you fly into when you book flights from Missouri to Santiago.

  • How long is the flight from Missouri to Santiago?

    Departing from Missouri to Santiago will take you 13h 25m. Airlines will cover a distance of 5137 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Missouri to Santiago?

    While some choose either Kansas City - Santiago Arturo Merino Benitez or Springfield-Branson - Santiago Arturo Merino Benitez, Lambert-St Louis - Santiago Arturo Merino Benitez is the most popular route from Missouri to Santiago.

  • Can I find deals for flights from Missouri to Santiago that include hotel bookings?

    Yes. In addition to deals on Missouri to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Santiago.

  • Can I find deals for business class flights from Missouri to Santiago?

    Yes. Cheapflights offers flight deals from Missouri to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Santiago?

    Currently, December is the cheapest month in which you can book a flight from Missouri to Santiago (average of $552). Flying from Missouri to Santiago in October is currently the most expensive (average of $924). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Missouri to Santiago

Discover the top 4 airlines that operate flights from Missouri to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$689Average$1,030FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$764Average$925FlexibilityNo cancel feeOn-time69%
LATAM AirlinesCheapest$773Average$929FlexibilityNo cancel feeOn-time81%
DeltaCheapest$802Average$1,013FlexibilityNo cancel feeOn-timeN/A

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