$250+ Cheap flights from Missouri to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/4. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
Mar 14 — Mar 211
1 adult, Economy
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Cheapest flights from Missouri to SantiagoExplore the most affordable flight options available from Missouri to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.
Explore the most affordable flight options available from Missouri to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.
This Mytrip deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2112:24 pm
MCI
- SCL
2 stops20h 15m
Multiple Airlines
Sat 3/2811:24 am
SCL
- MCI
2 stops26h 05m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$750
This Gurufare deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/106:38 pm
MCI
- SCL
2 stops34h 22m
LATAM Airlines
Sun 5/248:35 pm
SCL
- MCI
2 stops37h 44m
LATAM Airlines
Deal found 2/10![LATAM Airlines logo]()
$812
This LATAM Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/264:48 pm
MCI
- SCL
1 stop12h 52m
LATAM Airlines
Thu 4/26:40 am
SCL
- MCI
2 stops19h 32m
LATAM Airlines
Deal found 2/9![LATAM Airlines logo]()
$827
This LATAM Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/116:00 am
STL
- SCL
2 stops21h 35m
LATAM Airlines
Mon 3/234:35 am
SCL
- STL
2 stops21h 23m
LATAM Airlines
Deal found 2/10![LATAM Airlines logo]()
$830
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/2610:30 am
MCI
- SCL
2 stops17h 05m
Delta
Thu 4/28:45 pm
SCL
- MCI
2 stops22h 49m
Delta
Deal found 2/9![Delta logo]()
$832
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/118:17 am
STL
- SCL
2 stops21h 33m
United Airlines
Mon 3/239:45 pm
SCL
- STL
2 stops25h 22m
United Airlines
Deal found 2/11![United Airlines logo]()
$851
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1110:12 am
STL
- SCL
1 stop19h 28m
Delta
Mon 3/236:30 pm
SCL
- STL
2 stops18h 39m
Delta
Deal found 2/9![Delta logo]()
$858
This Ovago deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/138:00 am
MCI
- SCL
1 stop22h 15m
LATAM Airlines
Fri 7/38:40 pm
SCL
- MCI
1 stop14h 27m
LATAM Airlines
Deal found 2/9![LATAM Airlines logo]()
$859
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/117:00 am
STL
- SCL
1 stop22h 00m
American Airlines
Mon 3/239:20 pm
SCL
- STL
1 stop15h 12m
American Airlines
Deal found 2/11![American Airlines logo]()
$860
This LATAM Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/211:27 pm
STL
- SCL
2 stops16h 28m
LATAM Airlines
Sat 5/3011:05 pm
SCL
- STL
2 stops19h 57m
LATAM Airlines
Deal found 2/10![LATAM Airlines logo]()
$882
This LATAM Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2012:04 pm
STL
- SCL
1 stop17h 36m
LATAM Airlines
Mon 3/3011:00 pm
SCL
- STL
2 stops20h 53m
LATAM Airlines
Deal found 2/9![LATAM Airlines logo]()
$893
This Expedia deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/215:25 pm
MCI
- SCL
1 stop12h 15m
LATAM Airlines
Sat 3/2810:25 pm
SCL
- MCI
2 stops51h 47m
LATAM Airlines
Deal found 2/10![LATAM Airlines logo]()
$901
Best flights from Missouri to SantiagoDiscover carefully curated flight deals from Missouri to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 12, 2026.
Discover carefully curated flight deals from Missouri to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 12, 2026.
This Mytrip deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2112:24 pm
MCI
- SCL
2 stops20h 15m
Multiple Airlines
Sat 3/2811:24 am
SCL
- MCI
2 stops26h 05m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$750
This Gurufare deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/106:38 pm
MCI
- SCL
2 stops34h 22m
LATAM Airlines
Sun 5/248:35 pm
SCL
- MCI
2 stops37h 44m
LATAM Airlines
Deal found 2/10![LATAM Airlines logo]()
$812
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/2610:30 am
MCI
- SCL
2 stops17h 05m
Delta
Thu 4/28:45 pm
SCL
- MCI
2 stops22h 49m
Delta
Deal found 2/9![Delta logo]()
$832
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/118:17 am
STL
- SCL
2 stops21h 33m
United Airlines
Mon 3/239:45 pm
SCL
- STL
2 stops25h 22m
United Airlines
Deal found 2/11![United Airlines logo]()
$851
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/117:00 am
STL
- SCL
1 stop22h 00m
American Airlines
Mon 3/239:20 pm
SCL
- STL
1 stop15h 12m
American Airlines
Deal found 2/11![American Airlines logo]()
$860
This LATAM Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/261:25 pm
MCI
- SCL
1 stop16h 15m
LATAM Airlines
Thu 4/28:40 pm
SCL
- MCI
1 stop14h 45m
LATAM Airlines
Deal found 2/9![LATAM Airlines logo]()
$827
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1110:12 am
STL
- SCL
1 stop19h 28m
Delta
Mon 3/236:30 pm
SCL
- STL
2 stops18h 39m
Delta
Deal found 2/9![Delta logo]()
$858
This LATAM Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/116:00 am
STL
- SCL
2 stops21h 35m
LATAM Airlines
Mon 3/234:35 am
SCL
- STL
2 stops21h 23m
LATAM Airlines
Deal found 2/10![LATAM Airlines logo]()
$830
This Ovago deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/135:26 pm
MCI
- SCL
1 stop12h 49m
LATAM Airlines
Fri 7/38:40 pm
SCL
- MCI
1 stop16h 41m
LATAM Airlines
Deal found 2/10![LATAM Airlines logo]()
$870
This LATAM Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2012:04 pm
STL
- SCL
1 stop17h 36m
LATAM Airlines
Mon 3/3011:00 pm
SCL
- STL
2 stops20h 53m
LATAM Airlines
Deal found 2/9![LATAM Airlines logo]()
$893
This Expedia deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/215:25 pm
MCI
- SCL
1 stop12h 15m
LATAM Airlines
Sat 3/2810:25 pm
SCL
- MCI
2 stops51h 47m
LATAM Airlines
Deal found 2/10![LATAM Airlines logo]()
$901
This Travelocity deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/63:35 pm
SGF
- SCL
2 stops24h 50m
LATAM Airlines
Sat 7/1111:05 pm
SCL
- SGF
2 stops20h 05m
LATAM Airlines
Deal found 2/12![LATAM Airlines logo]()
$1,215
Last-minute flights from Missouri to SantiagoDiscover last-minute flight deals from Missouri to Santiago. Data last updated February 12, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Santiago. Data last updated February 12, 2026 and is based on user searches.
This LATAM Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/116:00 am
STL
- SCL
2 stops21h 35m
LATAM Airlines
Mon 3/234:35 am
SCL
- STL
2 stops21h 23m
LATAM Airlines
Deal found 2/10![LATAM Airlines logo]()
$830
This United Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/116:00 am
STL
- SCL
1 stop23h 50m
United Airlines
Mon 3/239:45 pm
SCL
- STL
2 stops22h 15m
United Airlines
Deal found 2/11![United Airlines logo]()
$851
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1110:12 am
STL
- SCL
1 stop19h 28m
Delta
Mon 3/236:30 pm
SCL
- STL
2 stops18h 39m
Delta
Deal found 2/9![Delta logo]()
$858
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/117:00 am
STL
- SCL
1 stop22h 00m
American Airlines
Mon 3/239:20 pm
SCL
- STL
1 stop15h 12m
American Airlines
Deal found 2/11![American Airlines logo]()
$860
This LATAM Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2012:04 pm
STL
- SCL
1 stop17h 36m
LATAM Airlines
Mon 3/3011:00 pm
SCL
- STL
2 stops20h 53m
LATAM Airlines
Deal found 2/9![LATAM Airlines logo]()
$893
This American Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/205:12 am
STL
- SCL
1 stop23h 48m
American Airlines
Mon 3/309:25 pm
SCL
- STL
1 stop15h 07m
American Airlines
Deal found 2/10![American Airlines logo]()
$898
This Mytrip deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2112:24 pm
MCI
- SCL
2 stops20h 15m
Multiple Airlines
Sat 3/2811:24 am
SCL
- MCI
2 stops26h 05m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$750
This Expedia deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/215:25 pm
MCI
- SCL
1 stop12h 15m
LATAM Airlines
Sat 3/2810:25 pm
SCL
- MCI
2 stops51h 47m
LATAM Airlines
Deal found 2/10![LATAM Airlines logo]()
$901
This LATAM Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/264:48 pm
MCI
- SCL
1 stop12h 52m
LATAM Airlines
Thu 4/26:40 am
SCL
- MCI
2 stops19h 32m
LATAM Airlines
Deal found 2/9![LATAM Airlines logo]()
$827
This Delta deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/2610:30 am
MCI
- SCL
2 stops17h 05m
Delta
Thu 4/28:45 pm
SCL
- MCI
2 stops22h 49m
Delta
Deal found 2/9![Delta logo]()
$832
This LATAM Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2810:30 am
MCI
- SCL
2 stops18h 15m
LATAM Airlines
Sat 4/45:50 pm
SCL
- MCI
2 stops20h 30m
LATAM Airlines
Deal found 2/10![LATAM Airlines logo]()
$938
This Delta deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2810:07 am
STL
- SCL
1 stop20h 08m
Delta
Sat 4/411:00 pm
SCL
- STL
2 stops24h 06m
Delta
Deal found 2/10![Delta logo]()
$943
One-way flights from Missouri to SantiagoSearch for one-way flight options from Missouri to Santiago. Find affordable one-way fares based on user searches. Data last updated February 12, 2026.
Search for one-way flight options from Missouri to Santiago. Find affordable one-way fares based on user searches. Data last updated February 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/411:13 am
MCI
- SCL
3 stops41h 17m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$250
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/288:40 pm
MCI
- SCL
3 stops32h 00m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$312
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/104:47 pm
STL
- SCL
1 stop13h 03m
United Airlines
Deal found 2/10![United Airlines logo]()
$413
This LATAM Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/106:00 am
STL
- SCL
3 stops30h 10m
LATAM Airlines
Deal found 2/10![LATAM Airlines logo]()
$417
This American Airlines deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:52 pm
MCI
- SCL
1 stop12h 13m
American Airlines
Deal found 2/11![American Airlines logo]()
$417
This Air Canada deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/94:05 pm
STL
- SCL
1 stop17h 10m
Air Canada
Deal found 2/10![Air Canada logo]()
$426
This KAYAK deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/289:35 am
MCI
- SCL
1 stop18h 20m
LATAM Airlines
Deal found 2/10![LATAM Airlines logo]()
$436
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/87:52 am
STL
- SCL
2 stops21h 48m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$440
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/153:48 pm
STL
- SCL
3 stops36h 42m
Multiple Airlines
Deal found 2/11![Multiple Airlines logo]()
$458
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/258:17 pm
STL
- SCL
3 stops39h 13m
Multiple Airlines
Deal found 2/10![Multiple Airlines logo]()
$464
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/97:40 am
STL
- SCL
2 stops22h 10m
United Airlines
Deal found 2/10![United Airlines logo]()
$480
This Delta deal was found by Cheapflights users on 2/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/177:10 am
STL
- SCL
1 stop21h 30m
Delta
Deal found 2/8![Delta logo]()
$484
Find flight deals from Missouri to Santiago
Keep the following information in mind while searching for Missouri to Santiago flight deals. Data was last updated February 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $750 (Mytrip) |
One-way from | $250 (Kiwi.com) |
Popular in | January |
Cheapest in | July |
Average price | $1,183 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
Use the filters below to find and compare flights from Missouri to Santiago that are best for you.
Fly from
Missouri
Fly to
Santiago
Route
Depart
Return
Price
Kansas CitySantiago
MCI - SCL
MCISCL
Kansas City
Sat 3/21
12:24 pm-10:39 am
2 stops20h 15m
Santiago Arturo Merino Benitez
Sat 3/28
11:24 am-11:29 am
2 stops26h 05m
$750
Kansas CitySantiago
MCI - SCL
MCISCL
Kansas City
Sun 5/10
6:38 pm-6:00 am
2 stops34h 22m
Santiago Arturo Merino Benitez
Sun 5/24
8:35 pm-9:19 am
2 stops37h 44m
$812
Kansas CitySantiago
MCI - SCL
MCISCL
Kansas City
Thu 3/26
1:25 pm-7:40 am
1 stop16h 15m
Santiago Arturo Merino Benitez
Thu 4/2
8:40 pm-9:25 am
1 stop14h 45m
$827
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 3/11
6:00 am-5:35 am
2 stops21h 35m
Santiago Arturo Merino Benitez
Mon 3/23
4:35 am-11:58 pm
2 stops21h 23m
$830
Kansas CitySantiago
MCI - SCL
MCISCL
Kansas City
Thu 3/26
10:30 am-5:35 am
2 stops17h 05m
Santiago Arturo Merino Benitez
Thu 4/2
8:45 pm-5:34 pm
2 stops22h 49m
$832
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 3/11
8:17 am-7:50 am
2 stops21h 33m
Santiago Arturo Merino Benitez
Mon 3/23
9:45 pm-9:07 pm
2 stops25h 22m
$851
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 3/11
10:12 am-7:40 am
1 stop19h 28m
Santiago Arturo Merino Benitez
Mon 3/23
6:30 pm-11:09 am
2 stops18h 39m
$858
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 3/11
7:00 am-7:00 am
1 stop22h 00m
Santiago Arturo Merino Benitez
Mon 3/23
9:20 pm-10:32 am
1 stop15h 12m
$860
Kansas CitySantiago
MCI - SCL
MCISCL
Kansas City
Sat 6/13
5:26 pm-7:15 am
1 stop12h 49m
Santiago Arturo Merino Benitez
Fri 7/3
8:40 pm-12:21 pm
1 stop16h 41m
$870
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Fri 3/20
12:04 pm-7:40 am
1 stop17h 36m
Santiago Arturo Merino Benitez
Mon 3/30
11:00 pm-5:53 pm
2 stops20h 53m
$893
Showing 1-10 of 27 results
Best time to book a flight from Missouri to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from Missouri with our price prediction graph.
MCI-SCL
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SGF-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
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Everything you need to know about your flight from Missouri to Santiago
USMO-SCL
MCI-SCL
STL-SCL
SGF-SCL
What is the cheapest month to book a flight from Missouri to Santiago?
Currently, March is the cheapest month in which you can book a flight from Missouri to Santiago (average of $585). Flying from Missouri to Santiago in June is currently the most expensive (average of $989). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Missouri to Santiago?
Related info for your journey
Find useful and relevant information for your journey from Missouri to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Missouri to Santiago
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Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Santiago by cabin class
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Missouri and Santiago flights
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Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on February 12, 2026.
Missouri to Santiago flights
Consider these flights traveling from Missouri to Santiago.
Top 3 airlines flying from Missouri to Santiago
Discover the top 3 airlines that operate flights from Missouri to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$689 | Average$1,074 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$755 | Average$1,028 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$801 | Average$913 | FlexibilityNo cancel fee | On-time81% |