HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santiago

$305+ Cheap flights from Missouri to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
Oct 27 — Nov 31
Mon 10/27
Mon 11/3
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Missouri to Santiago with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Missouri to Santiago

Keep the following information in mind while searching for Missouri to Santiago flight deals. Data was last updated September 27, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$752
(LATAM Airlines)

One-way from

$305
(Kiwi.com)

Popular in

December

Cheapest in

May

Average price

$1,018
Provider with most accurate pricing for Kansas City-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Kansas City-Santiago Arturo Merino Benitez flights.
Search Deals
From Missouri to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Missouri to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($66 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($23 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from Missouri to Santiago

Cheapest flights from Missouri to Santiago
Explore the most affordable flight options available from Missouri to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 27, 2025.

This LATAM Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/2711:04 amSTL - SCL
1 stop17h 36mLATAM Airlines
Mon 12/810:35 amSCL - STL
2 stops16h 06mLATAM Airlines
Deal found 9/26$752
This Delta deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/111:55 pmSTL - SCL
1 stop13h 15mDelta
Mon 12/1511:10 pmSCL - STL
1 stop16h 50mDelta
Deal found 9/25$764
This LATAM Airlines deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1012:18 pmMCI - SCL
1 stop16h 22mLATAM Airlines
Sun 11/164:35 amSCL - MCI
2 stops21h 00mLATAM Airlines
Deal found 9/26$764
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/47:50 amJLN - SCL
2 stops22h 00mUnited Airlines
Mon 12/810:45 pmSCL - JLN
2 stops27h 42mUnited Airlines
Deal found 9/25$768
This Orbitz deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/15:12 pmSTL - SCL
1 stop11h 28mLATAM Airlines
Sun 12/1410:25 pmSCL - STL
2 stops28h 16mLATAM Airlines
Deal found 9/26$789
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/67:00 amMCI - SCL
2 stops20h 40mDelta
Wed 12/106:30 pmSCL - MCI
2 stops17h 55mDelta
Deal found 9/27$804
This Orbitz deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/266:52 pmSTL - SCL
2 stops33h 08mLATAM Airlines
Sun 11/210:15 pmSCL - STL
2 stops44h 55mLATAM Airlines
Deal found 9/27$806
This LATAM Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/156:00 amSTL - SCL
2 stops22h 00mLATAM Airlines
Fri 10/2412:10 amSCL - STL
2 stops19h 52mLATAM Airlines
Deal found 9/25$808
This KAYAK deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/65:12 pmMCI - SCL
2 stops17h 53mLATAM Airlines
Tue 12/94:35 amSCL - MCI
2 stops21h 09mLATAM Airlines
Deal found 9/27$814
This Expedia deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/95:45 amMCI - SCL
2 stops45h 15mLATAM Airlines
Sun 11/166:30 pmSCL - MCI
2 stops31h 05mLATAM Airlines
Deal found 9/25$815
This SmartFares deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/135:12 pmSTL - SCL
1 stop33h 58mLATAM Airlines
Mon 1/128:25 amSCL - STL
3 stops29h 25mLATAM Airlines
Deal found 9/25$821
This Delta deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/111:55 amMCI - SCL
1 stop17h 45mDelta
Sat 11/2211:10 pmSCL - MCI
1 stop18h 10mDelta
Deal found 9/27$844

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 27, 2025.
Use the filters below to find and compare flights from Missouri to Santiago that are best for you.

Fly from

Missouri

Fly to

Santiago

Route

Depart

Return

Price

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 2/9

4:00 pm-3:30 pm

2 stops20h 30m

Santiago Arturo Merino Benitez

Thu 2/19

8:10 am-11:40 pm

2 stops18h 30m

$764

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 12/11

9:30 am-6:40 am

2 stops18h 10m

Santiago Arturo Merino Benitez

Mon 12/15

11:10 pm-10:41 am

1 stop14h 31m

$764

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Tue 2/10

10:00 am-6:40 am

2 stops17h 40m

Santiago Arturo Merino Benitez

Sun 2/15

12:25 am-6:04 pm

2 stops20h 39m

$764

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 2/9

10:00 am-7:00 am

1 stop18h 00m

Santiago Arturo Merino Benitez

Thu 2/19

11:15 pm-10:50 am

1 stop14h 35m

$764

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 2/9

10:00 am-7:00 am

1 stop18h 00m

Santiago Arturo Merino Benitez

Tue 2/17

6:30 pm-3:01 pm

2 stops23h 31m

$764

Kansas CitySantiago

MCI - SCL

MCISCL

Kansas City

Mon 11/10

10:23 am-5:50 am

2 stops16h 27m

Santiago Arturo Merino Benitez

Sun 11/16

4:35 am-11:56 pm

2 stops22h 21m

$764

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 2/12

10:00 am-6:40 am

2 stops17h 40m

Santiago Arturo Merino Benitez

Tue 2/17

11:15 pm-3:01 pm

1 stop18h 46m

$764

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 11/27

11:04 am-7:40 am

1 stop17h 36m

Santiago Arturo Merino Benitez

Mon 12/8

9:30 pm-8:25 am

1 stop13h 55m

$764

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Mon 2/9

10:00 am-7:00 am

1 stop18h 00m

Santiago Arturo Merino Benitez

Mon 2/16

6:30 pm-10:50 am

2 stops19h 20m

$764

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

Thu 10/23

7:05 am-4:30 am

2 stops19h 25m

Santiago Arturo Merino Benitez

Wed 10/29

12:20 am-9:28 pm

2 stops23h 08m

$764

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/24

Showing 1-10 of 32 results
1
2
3
4

Best time to book a flight from Missouri to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Santiago

What is the cheapest month to book a flight from Missouri to Santiago?

Currently, April is the cheapest month in which you can book a flight from Missouri to Santiago (average of $752). Flying from Missouri to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SCL?

Find hourly flight availability from Missouri to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 27, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Santiago as you normally would.

How much does it cost to fly round-trip from Missouri to Santiago?

Related info for your journey

Find useful and relevant information for your journey from Missouri to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago from Missouri?

    Santiago Arturo Merino Benitez (SCL), located 8.4 mi from the city center, is the airport you fly into when you book flights from Missouri to Santiago.

  • How long is the flight from Missouri to Santiago?

    Departing from Missouri to Santiago will take you 18h 10m. Airlines will cover a distance of 5137 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Missouri to Santiago?

    While some choose either Kansas City - Santiago Arturo Merino Benitez or Joplin - Santiago Arturo Merino Benitez, Lambert-St Louis - Santiago Arturo Merino Benitez is the most popular route from Missouri to Santiago.

  • Can I find deals for flights from Missouri to Santiago that include hotel bookings?

    Yes. In addition to deals on Missouri to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Santiago.

  • Can I find deals for business class flights from Missouri to Santiago?

    Yes. Cheapflights offers flight deals from Missouri to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Missouri to Santiago (average of $752). Flying from Missouri to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Santiago flights
Los Angeles to Santiago flights
Miami to Santiago flights
Dulles Intl to Santiago flights
Newark to Santiago flights
LaGuardia to Santiago flights
Hobby to Santiago flights
Reagan-National to Santiago flights
Baltimore to Santiago flights
Dallas/Fort Worth to Santiago flights
San Francisco to Santiago flights
Boston to Santiago flights
George Bush Intcntl to Santiago flights
O'Hare Intl to Santiago flights
Seattle to Santiago flights
Denver to Santiago flights
Orlando to Santiago flights
Atlanta to Santiago flights
Midway to Santiago flights
Ontario to Santiago flights
Sky Harbor Intl to Santiago flights
Love Field to Santiago flights
Fort Lauderdale to Santiago flights
Philadelphia to Santiago flights
Austin to Santiago flights
Minneapolis to Santiago flights
Tampa to Santiago flights
Charlotte to Santiago flights
Salt Lake City to Santiago flights
Portland to Santiago flights
Hartford to Santiago flights
Detroit to Santiago flights
St. Louis to Santiago flights
Indianapolis to Santiago flights
San Diego to Santiago flights
Nashville to Santiago flights
Las Vegas to Santiago flights
Miami to Punta Arenas flights
San Jose to Santiago flights
Cincinnati to Santiago flights
Lexington to Santiago flights
Tucson to Santiago flights
Raleigh to Santiago flights
John F Kennedy Intl to Punta Arenas flights
West Palm Beach to Santiago flights
Pittsburgh to Santiago flights
Richmond to Santiago flights
Denver to Punta Arenas flights
Sacramento to Santiago flights
Madison to Santiago flights

Top 4 airlines flying from Missouri to Santiago

Discover the top 4 airlines that operate flights from Missouri to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 27, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$762Average$911FlexibilityNo cancel feeOn-time81%
DeltaCheapest$802Average$1,037FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$803Average$925FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$807Average$1,025FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.