Copa's Dreams Business Class offers lie-flat seats on Boeing Max aircraft for enhanced comfort.
Copa offers a Panama Stopover program for up to 7 days at no extra cost.

Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $397 (Copa Airlines) |
One-way from | $192 (FlightHub) |
Popular in | December |
Cheapest in | October |
Average price | $583 |
Fly from
Fly to
Route
Depart
Return
Price
ChicagoSanta Cruz de la Sierra
ORD - VVI
ORDVVI
Chicago O'Hare Intl
Mon 11/10
6:56 am-10:46 pm
1 stop13h 50m
Santa Cruz de la Sierra Viru Viru Intl
Sun 11/16
1:09 am-12:46 pm
1 stop13h 37m
New YorkSanta Cruz de la Sierra
JFK - VVI
JFKVVI
New York John F Kennedy Intl
Mon 11/3
8:33 am-3:36 am
1 stop18h 03m
Santa Cruz de la Sierra Viru Viru Intl
Thu 11/13
11:40 am-2:59 am
1 stop16h 19m
MiamiSanta Cruz de la Sierra
MIA - VVI
MIAVVI
Miami
Sat 11/29
4:59 am-10:46 pm
1 stop16h 47m
Santa Cruz de la Sierra Viru Viru Intl
Thu 12/4
1:09 am-3:45 pm
1 stop15h 36m
MiamiSanta Cruz de la Sierra
MIA - VVI
MIAVVI
Miami
Wed 11/19
4:10 pm-3:36 am
1 stop10h 26m
Santa Cruz de la Sierra Viru Viru Intl
Tue 12/2
11:40 am-12:45 am
1 stop14h 05m
MiamiSanta Cruz de la Sierra
MIA - VVI
MIAVVI
Miami
Thu 12/4
5:34 am-10:46 pm
1 stop16h 12m
Santa Cruz de la Sierra Viru Viru Intl
Mon 12/8
1:09 am-11:21 am
1 stop11h 12m
MiamiSanta Cruz de la Sierra
MIA - VVI
MIAVVI
Miami
Fri 11/14
12:46 pm-10:46 pm
1 stop9h 00m
Santa Cruz de la Sierra Viru Viru Intl
Mon 11/24
11:40 am-12:45 am
1 stop14h 05m
MiamiSanta Cruz de la Sierra
MIA - VVI
MIAVVI
Miami
Wed 12/3
7:32 am-3:36 am
1 stop19h 04m
Santa Cruz de la Sierra Viru Viru Intl
Tue 12/9
11:40 am-9:22 pm
1 stop10h 42m
Washington, D.C.Santa Cruz de la Sierra
IAD - VVI
IADVVI
Washington, D.C. Dulles Intl
Sun 11/9
8:22 am-10:46 pm
1 stop13h 24m
Santa Cruz de la Sierra Viru Viru Intl
Sat 11/15
1:09 am-2:02 pm
1 stop13h 53m
Washington, D.C.Santa Cruz de la Sierra
IAD - VVI
IADVVI
Washington, D.C. Dulles Intl
Fri 11/14
3:24 pm-3:36 am
1 stop11h 12m
Santa Cruz de la Sierra Viru Viru Intl
Mon 11/17
11:40 am-11:33 pm
1 stop12h 53m
Washington, D.C.Santa Cruz de la Sierra
IAD - VVI
IADVVI
Washington, D.C. Dulles Intl
Fri 11/7
8:22 am-10:46 pm
1 stop13h 24m
Santa Cruz de la Sierra Viru Viru Intl
Thu 11/13
11:40 am-11:33 pm
1 stop12h 53m
Currently, February is the cheapest month in which you can book a flight from USA to Santa Cruz de la Sierra (average of $61). Flying from USA to Santa Cruz de la Sierra in August is currently the most expensive (average of $394). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
It’s optimal to fly from USA to Santa Cruz de la Sierra in the afternoon. By choosing this option you can save up to 19% on the cost of your flight, compared to a flight at noon.
Travelers seeking maximum savings on their USA to Santa Cruz de la Sierra flight should consider departing on Saturday mornings when fares are most often at their lowest. Friday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
Food
Comfort
Boarding
Crew
Entertainment
Overall
Reviews
Juan Pablo,Sep 2025
PTY - VVI
Food
Comfort
Boarding
Crew
Entertainment
Overall
Reviews
Juan Pablo,Sep 2025
PTY - VVI
Food
Comfort
Boarding
Crew
Entertainment
Overall
Reviews
Juan Pablo,Sep 2025
PTY - VVI
Food
Comfort
Boarding
Crew
Entertainment
Overall
Reviews
Juan Pablo,Sep 2025
PTY - VVI
Food
Comfort
Boarding
Crew
Entertainment
Overall
Reviews
Juan Pablo,Sep 2025
PTY - VVI
Food
Comfort
Boarding
Crew
Entertainment
Overall
Reviews
Juan Pablo,Sep 2025
PTY - VVI
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$296 | Average$751 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$380 | Average$741 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$479 | Average$1,135 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$524 | Average$700 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$581 | Average$878 | FlexibilityNo cancel fee | On-time69% |