Santa Cruz de la Sierra

$195+ Cheap flights from the United States to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.
LAX — VVI
Oct 15 — Oct 221
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Find cheap flights from USA to Santa Cruz de la Sierra with Cheapflights

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Cheap flight deals from USA to Santa Cruz de la Sierra

Keep the following information in mind while searching for USA to Santa Cruz de la Sierra flight deals. Data was last updated September 15, 2025.

Round-trip from

$395
(Mytrip)

One-way from

$195
(Mytrip)

Popular in

December

Cheapest in

October

Average price

$645
From USA to Santa Cruz de la Sierra Viru Viru Intl
One-way flight from USA to Santa Cruz de la Sierra Viru Viru Intl
Highest demand for flights based on searches. 16% potential increase in price ($165 potential increase over avg. RT price).
Cheapest flight prices on average. 10% potential price decrease ($76 potential savings vs. average RT price).
Average for round-trip flights in September 2025

Find flight deals from USA to Santa Cruz de la Sierra

Cheapest flights from USA to Santa Cruz de la Sierra
Explore the most affordable flight options available from USA to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Mytrip deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/165:00 pmMIA - VVI
1 stop8h 50mAvianca
Tue 10/212:50 amVVI - MIA
1 stop9h 40mAvianca
Deal found 9/13$395
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/275:12 pmMIA - VVI
1 stop10h 24mCopa Airlines
Mon 11/1011:40 amVVI - MIA
1 stop14h 05mCopa Airlines
Deal found 9/15$397
This Booking.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1612:25 pmMIA - VVI
1 stop10h 15mCopa Airlines
Tue 10/2111:59 amVVI - MIA
1 stop10h 43mCopa Airlines
Deal found 9/13$399
This Copa Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/262:16 amJFK - VVI
1 stop20h 24mCopa Airlines
Mon 11/311:40 amVVI - JFK
1 stop13h 06mCopa Airlines
Deal found 9/12$417
This Mytrip deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/112:19 amJFK - VVI
1 stop25h 17mCopa Airlines
Sat 10/181:09 amVVI - JFK
1 stop23h 37mCopa Airlines
Deal found 9/14$436
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2111:20 amMIA - VVI
1 stop15h 16mCopa Airlines
Fri 11/281:09 amVVI - MIA
1 stop11h 03mCopa Airlines
Deal found 9/15$443
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/252:16 amJFK - VVI
1 stop20h 24mCopa Airlines
Sat 11/111:40 amVVI - JFK
1 stop26h 17mCopa Airlines
Deal found 9/12$444
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/193:32 pmJFK - VVI
1 stop30h 53mCopa Airlines
Mon 10/611:59 amVVI - JFK
1 stop26h 00mCopa Airlines
Deal found 9/13$448
This Cheapflightsfares deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/164:05 amIAD - VVI
2 stops21h 45mAvianca
Thu 10/92:50 amVVI - IAD
2 stops25h 30mAvianca
Deal found 9/13$467
This Mytrip deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/289:35 amIAD - VVI
1 stop18h 01mCopa Airlines
Fri 10/101:09 amVVI - IAD
1 stop23h 21mCopa Airlines
Deal found 9/15$468
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/229:35 amIAD - VVI
1 stop18h 01mCopa Airlines
Tue 10/71:09 amVVI - IAD
1 stop13h 56mCopa Airlines
Deal found 9/14$469
This Copa Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2812:46 pmMIA - VVI
1 stop13h 50mCopa Airlines
Thu 12/1111:40 amVVI - MIA
1 stop10h 42mCopa Airlines
Deal found 9/14$472

Cheapflights Fare Finder

 
Customize your flight search to find flights from USA to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from the United States to Santa Cruz de la Sierra that are best for you.

Fly from

USA

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Mon 10/27

6:23 am-10:40 pm

1 stop16h 17m

Santa Cruz de la Sierra Viru Viru Intl

Sun 11/9

1:09 am-6:51 pm

1 stop18h 42m

$397

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Fri 10/24

12:25 pm-10:40 pm

1 stop10h 15m

Santa Cruz de la Sierra Viru Viru Intl

Mon 10/27

11:41 am-10:25 pm

1 stop10h 44m

$397

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Sat 11/1

5:59 am-10:46 pm

1 stop16h 47m

Santa Cruz de la Sierra Viru Viru Intl

Sat 11/15

11:40 am-9:22 pm

1 stop10h 42m

$397

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Fri 10/17

12:25 pm-10:40 pm

1 stop10h 15m

Santa Cruz de la Sierra Viru Viru Intl

Fri 10/31

1:09 am-2:49 pm

1 stop13h 40m

$397

New YorkSanta Cruz de la Sierra

JFK - VVI

JFKVVI

New York John F Kennedy Intl

Fri 11/14

2:44 pm-3:36 am

1 stop11h 52m

Santa Cruz de la Sierra Viru Viru Intl

Thu 11/27

1:09 am-12:57 pm

1 stop12h 48m

$417

New YorkSanta Cruz de la Sierra

JFK - VVI

JFKVVI

New York John F Kennedy Intl

Sun 10/12

10:00 am-3:36 am

1 stop17h 36m

Santa Cruz de la Sierra Viru Viru Intl

Sat 10/18

1:09 am-1:59 pm

1 stop12h 50m

$417

New YorkSanta Cruz de la Sierra

JFK - VVI

JFKVVI

New York John F Kennedy Intl

Sun 10/26

2:16 am-10:40 pm

1 stop20h 24m

Santa Cruz de la Sierra Viru Viru Intl

Sun 11/2

1:09 am-5:17 pm

1 stop17h 08m

$417

New YorkSanta Cruz de la Sierra

JFK - VVI

JFKVVI

New York John F Kennedy Intl

Sat 10/25

2:16 am-10:40 pm

1 stop20h 24m

Santa Cruz de la Sierra Viru Viru Intl

Fri 10/31

1:09 am-1:57 pm

1 stop12h 48m

$417

MiamiSanta Cruz de la Sierra

MIA - VVI

MIAVVI

Miami

Thu 11/20

7:32 am-10:46 pm

1 stop14h 14m

Santa Cruz de la Sierra Viru Viru Intl

Thu 11/27

1:09 am-6:51 pm

1 stop18h 42m

$443

NewarkSanta Cruz de la Sierra

EWR - VVI

EWRVVI

Newark

Wed 10/1

10:05 am-1:50 am

2 stops15h 45m

Santa Cruz de la Sierra Viru Viru Intl

Thu 10/9

2:50 am-7:22 pm

2 stops16h 32m

$502

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 60 results
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The best insider tips for theUnited States to Santa Cruz de la Sierra flights

Snippets provided in this section are AI-generated based on a summarization of Cheapflights-commissioned articles. The articles are presented as-is, for general informational purposes only, and may not be up-to-date. The opinions contained in the articles are original to the author and reflect their authentic experience, which may vary significantly from the experience of others.
Cheapflights partnered with top experts to bring you the best recommendations for your theUnited States to Santa Cruz de la Sierra trip
Airlines
Copa Airlines

Copa's Dreams Business Class offers lie-flat seats on Boeing Max aircraft for enhanced comfort.


Copa offers a Panama Stopover program for up to 7 days at no extra cost.

Avianca

Avianca's Business Class offers lie-flat seats and luxury amenity kits on long-haul flights.


Avianca's Classic fare includes a checked bag and seat selection, ideal for international flights.

United Airlines

United's Polaris Business Class offers lie-flat seats and Saks Fifth Avenue bedding on long-haul flights.


United's Premium Plus offers extra legroom, upgraded meals, and two checked bags on international routes.

LATAM Airlines

LATAM's Premium Business offers lie-flat seats and two checked bags on international flights.


LATAM's LATAM+ seats offer more legroom and earlier boarding on international flights.

Our travel experts
Paul Rubio

Paul Rubio

Expert on Copa Airlines and LATAM Airlines

Paul Rubio

Paul Rubio

Travel journalist and photographer Paul Rubio is a Miami native (and current resident), who has lived in nine countries and traveled to 137. He is an expert in luxury travel, eco-travel, loyalty programs, hotels, airports and airlines. He is a contributing editor at AFAR, Condé Nast Traveler, LUXURY Magazine, and Palm Beach Illustrated.

Read more
Matt Meltzer

Matt Meltzer

Expert on Avianca

Matt Meltzer

Matt Meltzer

Matt Meltzer has been a travel writer for over a decade, covering U.S. domestic locations and hotels for Thrillist, Fifty Grande, Matador Network, Conde Nast Traveler, and other top publications. He's won multiple travel journalism awards from the Society of American Travel Writers and North American Travel Journalists Association, and currently resides in South Florida.

Read more
Harriet Baskas

Harriet Baskas

Expert on United Airlines

Harriet Baskas

Harriet Baskas

Harriet is an award-winning journalist who is happiest in an airport or an unusual museum. Her stories about airports, air travel, and the business of travel have appeared on NBC News, CNBC, USA TODAY, The Points Guy and other outlets. She is the creator of the StuckatTheAirport.com blog and the author of nine books. When not out on the road or exploring the latest airport amenities, she’s home in Seattle getting ready for the next adventure.

Read more

Best time to book a flight from USA to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from USA with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from the United States to Santa Cruz de la Sierra

What is the cheapest month to book a flight from USA to Santa Cruz de la Sierra?

Currently, October is the cheapest month in which you can book a flight from USA to Santa Cruz de la Sierra (average of $597). Flying from USA to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from US to VVI?

Find hourly flight availability from USA to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from USA to Santa Cruz de la Sierra as you normally would.

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated September 15, 2025.
See what other customers who have flown with Copa Airlines, LATAM Airlines, and United Airlines from the United States to Santa Cruz de la Sierra have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Overall

7.6

Crew

8.1

Food

6.8

Entertainment

6.8

Boarding

7.8

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Overall

7.6

Crew

8.1

Food

6.8

Entertainment

6.8

Boarding

7.8

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Overall

7.6

Crew

8.1

Food

6.8

Entertainment

6.8

Boarding

7.8

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Overall

7.6

Crew

8.1

Food

6.8

Entertainment

6.8

Boarding

7.8

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Overall

7.6

Crew

8.1

Food

6.8

Entertainment

6.8

Boarding

7.8

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Overall

7.6

Crew

8.1

Food

6.8

Entertainment

6.8

Boarding

7.8

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from USA to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly into for flights to Santa Cruz de la Sierra from United States?

    For a flight from United States to Santa Cruz de la Sierra, you will be flying into Viru Viru Intl. Santa Cruz de la Sierra Viru Viru Intl (VVI) is just 11.5 mi from the center of the city.

  • How long is the flight from USA to Santa Cruz de la Sierra?

    Copa Airlines, United Airlines, and Avianca can get you from USA to Santa Cruz de la Sierra in just under 16h 17m. Your travel time can differ by up to 7h 08m. USA and Santa Cruz de la Sierra are separated by a distance of 3213 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from USA to Santa Cruz de la Sierra one-way?

    The cheapest airlines for a one-way flight from USA to Santa Cruz de la Sierra are Avianca ($195), Copa Airlines ($250), and United Airlines ($251).

  • What are the most popular routes from USA to Santa Cruz de la Sierra?

  • Can I find deals for flights from USA to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on USA to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from USA to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from USA to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from USA to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from USA to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from USA to Santa Cruz de la Sierra?

    Currently, October is the cheapest month in which you can book a flight from USA to Santa Cruz de la Sierra (average of $597). Flying from USA to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for USA to Santa Cruz de la Sierra

See prices for flight routes from nearby airports that may be better suited for you.

Top 5 airlines flying from USA to Santa Cruz de la Sierra

Discover the top 5 airlines that operate flights from USA to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$376Average$763FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$379Average$737FlexibilityNo cancel feeOn-time70%
LATAM AirlinesCheapest$479Average$1,155FlexibilityNo cancel feeOn-time81%
BoACheapest$526Average$693FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$581Average$864FlexibilityNo cancel feeOn-time69%

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