$315+ Cheap flights from O'Hare Intl (ORD) to Santa Cruz de la Sierra (VVI)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/26. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — VVI
Nov 24 — Dec 11
Round-trip
1 adult, Economy
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Find cheap flights from O'Hare Intl to Santa Cruz de la Sierra with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from O'Hare Intl to Santa Cruz de la Sierra
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Cheapest flights from O'Hare Intl to Santa Cruz de la SierraExplore the most affordable flight options available from O'Hare Intl to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
Explore the most affordable flight options available from O'Hare Intl to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
This FlightHub deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3111:30 pm -
1 stop26h 10m
Mon 11/23:45 am -
1 stop18h 45m
Deal found 10/21![Avianca logo]()
$675
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:00 am -
2 stops39h 38m
Wed 12/911:42 am -
2 stops23h 55m
Deal found 10/21![United Airlines logo]()
$683
This United deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:29 pm -
2 stops31h 09m
Tue 11/33:45 am -
2 stops21h 41m
Deal found 10/21![Multiple Airlines logo]()
$695
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:29 am -
2 stops18h 08m
Wed 11/1111:41 am -
2 stops22h 11m
Deal found 10/24![United Airlines logo]()
$696
This United deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:29 am -
2 stops42h 11m
Wed 11/1811:41 am -
2 stops24h 04m
Deal found 10/24![Multiple Airlines logo]()
$705
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/319:41 pm -
2 stops23h 57m
Wed 11/411:41 am -
2 stops23h 30m
Deal found 10/24![United Airlines logo]()
$709
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/19:35 pm -
2 stops23h 03m
Tue 11/1711:41 am -
2 stops21h 49m
Deal found 10/24![United Airlines logo]()
$716
This Copa Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/42:13 pm -
1 stop11h 24m
Wed 11/1111:41 am -
1 stop14h 30m
Deal found 10/24![Copa Airlines logo]()
$717
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:00 am -
2 stops39h 38m
Mon 11/3011:41 am -
2 stops54h 39m
Deal found 10/22![United Airlines logo]()
$725
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/19:35 pm -
2 stops28h 02m
Thu 11/511:41 am -
2 stops36h 37m
Deal found 10/20![United Airlines logo]()
$726
Best flights from O'Hare Intl to Santa Cruz de la SierraDiscover carefully curated flight deals from O'Hare Intl to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
Discover carefully curated flight deals from O'Hare Intl to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:00 am -
2 stops39h 38m
Wed 12/911:42 am -
2 stops23h 55m
Deal found 10/21![United Airlines logo]()
$683
This Copa Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/42:13 pm -
1 stop11h 24m
Wed 11/1111:41 am -
1 stop14h 30m
Deal found 10/24![Copa Airlines logo]()
$717
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:29 am -
2 stops18h 08m
Wed 11/1111:41 am -
2 stops22h 11m
Deal found 10/24![United Airlines logo]()
$696
This Copa Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/187:35 am -
1 stop13h 03m
Tue 12/81:10 am -
1 stop13h 36m
Deal found 10/21![Copa Airlines logo]()
$778
This Copa Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/107:35 am -
1 stop13h 07m
Thu 2/251:18 am -
1 stop13h 28m
Deal found 10/24![Copa Airlines logo]()
$800
This Copa Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/52:13 pm -
1 stop30h 35m
Sat 12/1211:42 am -
1 stop27h 04m
Deal found 10/21![Copa Airlines logo]()
$985
Last-minute flights from O'Hare Intl to Santa Cruz de la SierraDiscover last-minute flight deals from O'Hare Intl to Santa Cruz de la Sierra. Data last updated October 25, 2026 and is based on user searches.
Discover last-minute flight deals from O'Hare Intl to Santa Cruz de la Sierra. Data last updated October 25, 2026 and is based on user searches.
This United deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:29 am -
2 stops42h 11m
Wed 11/1811:41 am -
2 stops24h 04m
Deal found 10/24![Multiple Airlines logo]()
$705
This FlightHub deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3111:30 pm -
1 stop26h 10m
Mon 11/23:45 am -
1 stop18h 45m
Deal found 10/21![Avianca logo]()
$675
This United deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:29 pm -
2 stops31h 09m
Tue 11/33:45 am -
2 stops21h 41m
Deal found 10/21![Multiple Airlines logo]()
$695
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/319:41 pm -
2 stops23h 57m
Wed 11/411:41 am -
2 stops23h 30m
Deal found 10/24![United Airlines logo]()
$709
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/19:35 pm -
2 stops23h 03m
Tue 11/1711:41 am -
2 stops21h 49m
Deal found 10/24![United Airlines logo]()
$716
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/19:35 pm -
2 stops28h 02m
Thu 11/511:41 am -
2 stops36h 37m
Deal found 10/20![United Airlines logo]()
$726
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:29 am -
2 stops18h 08m
Wed 11/1111:41 am -
2 stops22h 11m
Deal found 10/24![United Airlines logo]()
$696
This Copa Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/42:13 pm -
1 stop11h 24m
Wed 11/1111:41 am -
1 stop14h 30m
Deal found 10/24![Copa Airlines logo]()
$717
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:00 am -
2 stops39h 38m
Wed 12/911:42 am -
2 stops23h 55m
Deal found 10/21![United Airlines logo]()
$683
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/185:00 am -
2 stops39h 38m
Mon 11/3011:41 am -
2 stops54h 39m
Deal found 10/22![United Airlines logo]()
$725
One-way flights from O'Hare Intl to Santa Cruz de la SierraSearch for one-way flight options from O'Hare Intl to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
Search for one-way flight options from O'Hare Intl to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/265:00 am -
2 stops39h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![United Airlines logo]()
$315
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:29 pm -
2 stops31h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/24![United Airlines logo]()
$328
This Copa Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/42:13 pm -
1 stop11h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/24![Copa Airlines logo]()
$361
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/262:17 pm -
3 stops30h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![Multiple Airlines logo]()
$447
This Copa Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/267:35 am -
1 stop13h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![Copa Airlines logo]()
$469
Find flight deals from O'Hare Intl to Santa Cruz de la Sierra
Discover tips and strategies to find the most affordable flight options for your journey from O'Hare Intl (ORD) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 25, 2026.
Most accurate provider | Ovago 3 stars |
|---|---|
Most trusted provider | Ovago 3 stars |
Round-trip from | $648 (Copa Airlines) |
One-way from | $300 (Copa Airlines) |
Popular in | December |
Cheapest in | April |
Average price | $962 |
Cheapflights Fare Finder
Customize your flight search to find flights from O'Hare Intl to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ChicagoSanta Cruz de la Sierra
ORD Chicago O'Hare Intl - VVI Santa Cruz de la Sierra Viru Viru Intl
ORDVVI
Chicago O'Hare Intl
Thu 11/26
5:00 am-10:38 pm
2 stops39h 38m
Santa Cruz de la Sierra Viru Viru Intl
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$315
ChicagoSanta Cruz de la Sierra
ORD Chicago O'Hare Intl - VVI Santa Cruz de la Sierra Viru Viru Intl
ORDVVI
Chicago O'Hare Intl
Sat 10/31
2:29 pm-10:38 pm
2 stops31h 09m
Santa Cruz de la Sierra Viru Viru Intl
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$328
ChicagoSanta Cruz de la Sierra
ORD Chicago O'Hare Intl - VVI Santa Cruz de la Sierra Viru Viru Intl
ORDVVI
Chicago O'Hare Intl
Wed 11/4
6:55 am-3:37 am
2 stops18h 42m
Santa Cruz de la Sierra Viru Viru Intl
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$328
Quickest round-trip
ChicagoSanta Cruz de la Sierra
ORD Chicago O'Hare Intl - VVI Santa Cruz de la Sierra Viru Viru Intl
ORDVVI
Chicago O'Hare Intl
Wed 11/4
2:13 pm-3:37 am
1 stop11h 24m
Santa Cruz de la Sierra Viru Viru Intl
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$361
ChicagoSanta Cruz de la Sierra
ORD Chicago O'Hare Intl - VVI Santa Cruz de la Sierra Viru Viru Intl
ORDVVI
Chicago O'Hare Intl
Thu 11/26
7:35 am-10:38 pm
1 stop13h 03m
Santa Cruz de la Sierra Viru Viru Intl
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$469
ChicagoSanta Cruz de la Sierra
ORD Chicago O'Hare Intl - VVI Santa Cruz de la Sierra Viru Viru Intl
ORDVVI
Chicago O'Hare Intl
Wed 11/18
5:00 am-10:38 pm
2 stops39h 38m
Santa Cruz de la Sierra Viru Viru Intl
Wed 12/9
11:42 am-9:37 am
2 stops23h 55m
$683
ChicagoSanta Cruz de la Sierra
ORD Chicago O'Hare Intl - VVI Santa Cruz de la Sierra Viru Viru Intl
ORDVVI
Chicago O'Hare Intl
Wed 11/4
7:29 am-3:37 am
2 stops18h 08m
Santa Cruz de la Sierra Viru Viru Intl
Wed 11/11
11:41 am-7:52 am
2 stops22h 11m
$696
ChicagoSanta Cruz de la Sierra
ORD Chicago O'Hare Intl - VVI Santa Cruz de la Sierra Viru Viru Intl
ORDVVI
Chicago O'Hare Intl
Wed 11/4
2:13 pm-3:37 am
1 stop11h 24m
Santa Cruz de la Sierra Viru Viru Intl
Wed 11/11
11:41 am-12:11 am
1 stop14h 30m
$717
ChicagoSanta Cruz de la Sierra
ORD Chicago O'Hare Intl - VVI Santa Cruz de la Sierra Viru Viru Intl
ORDVVI
Chicago O'Hare Intl
Wed 11/18
7:35 am-10:38 pm
1 stop13h 03m
Santa Cruz de la Sierra Viru Viru Intl
Tue 12/8
1:10 am-12:46 pm
1 stop13h 36m
$778
ChicagoSanta Cruz de la Sierra
ORD Chicago O'Hare Intl - VVI Santa Cruz de la Sierra Viru Viru Intl
ORDVVI
Chicago O'Hare Intl
Wed 2/10
7:35 am-10:42 pm
1 stop13h 07m
Santa Cruz de la Sierra Viru Viru Intl
Thu 2/25
1:18 am-12:46 pm
1 stop13h 28m
$800
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from O'Hare Intl to Santa Cruz de la Sierra
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from O'Hare Intl to Santa Cruz de la Sierra in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Chicago O'Hare Intl Airport-Santa Cruz de la Sierra flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on Chicago O'Hare Intl Airport-Santa Cruz de la Sierra flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from Chicago O'Hare Intl Airport-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Chicago O'Hare Intl Airport-Santa Cruz de la Sierra flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Chicago O'Hare Intl Airport-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from O'Hare Intl to Santa Cruz de la Sierra
Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from O'Hare Intl with our price prediction graph.
ORD-VVI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra
What is the cheapest month to book a flight from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra?
Currently, April is the cheapest month in which you can book a flight from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra (average of $610). Flying from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra in December is currently the most expensive (average of $1,176). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra?
Airfare is below average for this route at the moment.
Chicago O'Hare Intl Airport to Santa Cruz de la Sierra flights typically cost between $710 and $908 in April.The cheapest round-trip price found within the last 5 days was $676 on Copa Airlines (Apr 9-Apr 23).
Reviews of airlines servicing Santa Cruz de la Sierra
Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated October 25, 2026.
Read reviews from past customers who have flown Copa Airlines and United Airlines from Chicago O'Hare Intl Airport to Santa Cruz de la Sierra. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.1
Overall
7.6
Boarding
7.8
Food
7.0
Comfort
7.5
Entertainment
6.9
Reviews
1 / 20
2.0
MediocreAnonymous,Oct 2026
BOS - PTY
Crew
8.1
Overall
7.6
Boarding
7.8
Food
7.0
Comfort
7.5
Entertainment
6.9
Reviews
1 / 20
2.0
MediocreAnonymous,Oct 2026
BOS - PTY
Crew
8.1
Overall
7.6
Boarding
7.8
Food
7.0
Comfort
7.5
Entertainment
6.9
Reviews
1 / 20
2.0
MediocreAnonymous,Oct 2026
BOS - PTY
Related info for your journey
Find useful and relevant information for your journey from O'Hare Intl to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for O'Hare Intl to Santa Cruz de la Sierra
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Complete your trip
Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from O'Hare Intl to Santa Cruz de la Sierra by cabin class
Find flights from O'Hare Intl to Santa Cruz de la Sierra, based on your preferred cabin class, be it economy, premium economy, business, or first class.
O'Hare Intl and Santa Cruz de la Sierra flights
Browse other O'Hare Intl and Santa Cruz de la Sierra flight options. Last updated on October 25, 2026.
Other flights from O'Hare Intl
Browse through other flights departing from O'Hare Intl. Flights are based on user searches made on Cheapflights and were last updated on October 25, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from O'Hare Intl to Santa Cruz de la Sierra
Discover the top 2 airlines that operate flights from O'Hare Intl to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$506 | Average$679 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$516 | Average$821 | FlexibilityNo cancel fee | On-time70% |