$422+ Cheap flights from Santa Cruz de la Sierra (VVI) to O'Hare Intl (ORD)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/26. Fares are subject to change and may not be available on all flights or dates of travel.
VVI — ORD
May 26 — Jun 21
Round-trip
1 adult, Economy
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Find cheap flights from Santa Cruz de la Sierra to O'Hare Intl with Cheapflights
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Best
Last-minute
One-way
Cheapest flights from Santa Cruz de la Sierra to O'Hare IntlExplore the most affordable flight options available from Santa Cruz de la Sierra to O'Hare Intl. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 26, 2026.
Explore the most affordable flight options available from Santa Cruz de la Sierra to O'Hare Intl. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 26, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/103:35 am
VVI
- ORD
2 stops33h 05m
Multiple Airlines
Sun 5/173:21 pm
ORD
- VVI
1 stop11h 10m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$852
This Copa Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/911:47 am
VVI
- ORD
1 stop14h 28m
Copa Airlines
Wed 5/278:02 am
ORD
- VVI
1 stop13h 36m
Copa Airlines
Deal found 4/21![Copa Airlines logo]()
$886
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1111:47 am
VVI
- ORD
2 stops22h 50m
United Airlines
Sat 5/169:30 pm
ORD
- VVI
2 stops24h 08m
United Airlines
Deal found 4/25![United Airlines logo]()
$889
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/103:35 am
VVI
- ORD
2 stops33h 05m
Multiple Airlines
Mon 5/189:20 am
ORD
- VVI
1 stop18h 30m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$925
This BusinessClass deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1111:47 am
VVI
- ORD
2 stops37h 58m
Copa Airlines
Sun 5/176:13 pm
ORD
- VVI
2 stops27h 25m
Copa Airlines
Deal found 4/24![Copa Airlines logo]()
$929
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/193:35 am
VVI
- ORD
2 stops37h 33m
Multiple Airlines
Mon 8/37:10 am
ORD
- VVI
1 stop32h 50m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$933
This Mytrip deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/33:35 am
VVI
- ORD
3 stops32h 55m
Multiple Airlines
Wed 5/68:00 am
ORD
- VVI
2 stops17h 30m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$941
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/203:35 am
VVI
- ORD
2 stops33h 50m
Multiple Airlines
Mon 8/37:10 am
ORD
- VVI
1 stop32h 50m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$956
This BusinessClass deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1211:47 am
VVI
- ORD
2 stops33h 20m
Copa Airlines
Sun 5/176:13 pm
ORD
- VVI
2 stops27h 25m
Copa Airlines
Deal found 4/24![Copa Airlines logo]()
$960
This oojo deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/63:35 am
VVI
- ORD
1 stop18h 45m
Avianca
Thu 5/2811:20 pm
ORD
- VVI
1 stop26h 10m
Avianca
Deal found 4/21![Avianca logo]()
$966
Best flights from Santa Cruz de la Sierra to O'Hare IntlDiscover carefully curated flight deals from Santa Cruz de la Sierra to O'Hare Intl that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 26, 2026.
Discover carefully curated flight deals from Santa Cruz de la Sierra to O'Hare Intl that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 26, 2026.
This Copa Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/911:47 am
VVI
- ORD
1 stop14h 28m
Copa Airlines
Wed 5/278:02 am
ORD
- VVI
1 stop13h 36m
Copa Airlines
Deal found 4/21![Copa Airlines logo]()
$886
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1111:47 am
VVI
- ORD
2 stops22h 50m
United Airlines
Sat 5/169:30 pm
ORD
- VVI
2 stops24h 08m
United Airlines
Deal found 4/25![United Airlines logo]()
$889
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/103:35 am
VVI
- ORD
2 stops33h 05m
Multiple Airlines
Mon 5/189:20 am
ORD
- VVI
1 stop18h 30m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$925
This oojo deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/63:35 am
VVI
- ORD
1 stop18h 45m
Avianca
Thu 5/2811:20 pm
ORD
- VVI
1 stop26h 10m
Avianca
Deal found 4/22![Avianca logo]()
$966
This Copa Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1111:47 am
VVI
- ORD
1 stop14h 28m
Copa Airlines
Sun 5/173:21 pm
ORD
- VVI
1 stop11h 10m
Copa Airlines
Deal found 4/22![Copa Airlines logo]()
$886
This Priceline deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/73:35 am
VVI
- ORD
1 stop18h 45m
Multiple Airlines
Sun 5/178:35 am
ORD
- VVI
2 stops16h 55m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$991
This Avianca deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/213:35 am
VVI
- ORD
1 stop18h 45m
Avianca
Mon 5/2511:20 pm
ORD
- VVI
1 stop26h 10m
Avianca
Deal found 4/25![Avianca logo]()
$994
This Avianca deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/73:35 am
VVI
- ORD
1 stop18h 45m
Avianca
Tue 5/1211:20 pm
ORD
- VVI
1 stop26h 10m
Avianca
Deal found 4/22![Avianca logo]()
$994
This Avianca deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/103:35 am
VVI
- ORD
1 stop18h 45m
Avianca
Sat 5/1610:35 am
ORD
- VVI
2 stops14h 55m
Avianca
Deal found 4/25![Avianca logo]()
$1,035
Last-minute flights from Santa Cruz de la Sierra to O'Hare IntlDiscover last-minute flight deals from Santa Cruz de la Sierra to O'Hare Intl. Data last updated April 26, 2026 and is based on user searches.
Discover last-minute flight deals from Santa Cruz de la Sierra to O'Hare Intl. Data last updated April 26, 2026 and is based on user searches.
This Mytrip deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/33:35 am
VVI
- ORD
3 stops32h 55m
Multiple Airlines
Wed 5/68:00 am
ORD
- VVI
2 stops17h 30m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$941
This oojo deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/63:35 am
VVI
- ORD
1 stop18h 45m
Avianca
Thu 5/2811:20 pm
ORD
- VVI
1 stop26h 10m
Avianca
Deal found 4/21![Avianca logo]()
$966
This FlightHub deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/63:35 am
VVI
- ORD
1 stop18h 45m
Avianca
Sat 5/1611:20 pm
ORD
- VVI
1 stop26h 10m
Avianca
Deal found 4/23![Avianca logo]()
$969
This Copa Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/911:47 am
VVI
- ORD
1 stop14h 28m
Copa Airlines
Wed 5/278:02 am
ORD
- VVI
1 stop13h 36m
Copa Airlines
Deal found 4/21![Copa Airlines logo]()
$886
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/103:35 am
VVI
- ORD
2 stops33h 05m
Multiple Airlines
Sun 5/173:21 pm
ORD
- VVI
1 stop11h 10m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$852
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/103:35 am
VVI
- ORD
2 stops33h 05m
Multiple Airlines
Mon 5/189:20 am
ORD
- VVI
1 stop18h 30m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$925
This United Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1111:47 am
VVI
- ORD
2 stops22h 50m
United Airlines
Sat 5/169:30 pm
ORD
- VVI
2 stops24h 08m
United Airlines
Deal found 4/25![United Airlines logo]()
$889
This BusinessClass deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1111:47 am
VVI
- ORD
2 stops37h 58m
Copa Airlines
Sun 5/176:13 pm
ORD
- VVI
2 stops27h 25m
Copa Airlines
Deal found 4/24![Copa Airlines logo]()
$929
This BusinessClass deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1211:47 am
VVI
- ORD
2 stops33h 20m
Copa Airlines
Sun 5/176:13 pm
ORD
- VVI
2 stops27h 25m
Copa Airlines
Deal found 4/24![Copa Airlines logo]()
$960
One-way flights from Santa Cruz de la Sierra to O'Hare IntlSearch for one-way flight options from Santa Cruz de la Sierra to O'Hare Intl. Find affordable one-way fares based on user searches. Data last updated April 26, 2026.
Search for one-way flight options from Santa Cruz de la Sierra to O'Hare Intl. Find affordable one-way fares based on user searches. Data last updated April 26, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/2611:47 am
VVI
- ORD
3 stops45h 08m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$422
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/201:12 am
VVI
- ORD
2 stops23h 44m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$427
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1811:47 am
VVI
- ORD
3 stops33h 04m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$433
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/211:12 am
VVI
- ORD
3 stops43h 29m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$443
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/2511:47 am
VVI
- ORD
3 stops45h 08m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$458
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2311:47 am
VVI
- ORD
2 stops37h 09m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$469
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/193:35 am
VVI
- ORD
2 stops34h 02m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$495
Find flight deals from Santa Cruz de la Sierra to O'Hare Intl
Discover tips and strategies to find the most affordable flight options for your journey from Santa Cruz de la Sierra (VVI) to O'Hare Intl (ORD). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $852 (Kiwi.com) |
One-way from | $422 (Kiwi.com) |
Popular in | February |
Cheapest in | November |
Average price | $725 |
Cheapflights Fare Finder
Customize your flight search to find flights from Santa Cruz de la Sierra to O'Hare Intl that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 26, 2026.
Use the filters below to find and compare flights from Santa Cruz de la Sierra to Chicago O'Hare Intl Airport that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Santa Cruz de la SierraChicago
VVI - ORD
VVIORD
Santa Cruz de la Sierra Viru Viru Intl
Sat 5/9
11:47 am-1:15 am
1 stop14h 28m
Chicago O'Hare Intl
Wed 5/27
8:02 am-10:38 pm
1 stop13h 36m
$886
Quickest round-trip
Santa Cruz de la SierraChicago
VVI - ORD
VVIORD
Santa Cruz de la Sierra Viru Viru Intl
Mon 5/11
11:47 am-1:15 am
1 stop14h 28m
Chicago O'Hare Intl
Sun 5/17
3:21 pm-3:31 am
1 stop11h 10m
$886
Santa Cruz de la SierraChicago
VVI - ORD
VVIORD
Santa Cruz de la Sierra Viru Viru Intl
Mon 5/11
11:47 am-9:37 am
2 stops22h 50m
Chicago O'Hare Intl
Sat 5/16
9:30 pm-10:38 pm
2 stops24h 08m
$889
Santa Cruz de la SierraChicago
VVI - ORD
VVIORD
Santa Cruz de la Sierra Viru Viru Intl
Sun 5/10
3:35 am-11:40 am
2 stops33h 05m
Chicago O'Hare Intl
Mon 5/18
9:20 am-4:50 am
1 stop18h 30m
$925
Santa Cruz de la SierraChicago
VVI - ORD
VVIORD
Santa Cruz de la Sierra Viru Viru Intl
Wed 5/6
3:35 am-9:20 pm
1 stop18h 45m
Chicago O'Hare Intl
Thu 5/28
11:20 pm-2:30 am
1 stop26h 10m
$966
Santa Cruz de la SierraChicago
VVI - ORD
VVIORD
Santa Cruz de la Sierra Viru Viru Intl
Thu 5/7
3:35 am-9:20 pm
1 stop18h 45m
Chicago O'Hare Intl
Sun 5/17
8:35 am-2:30 am
2 stops16h 55m
$991
Santa Cruz de la SierraChicago
VVI - ORD
VVIORD
Santa Cruz de la Sierra Viru Viru Intl
Thu 5/21
3:35 am-9:20 pm
1 stop18h 45m
Chicago O'Hare Intl
Mon 5/25
11:20 pm-2:30 am
1 stop26h 10m
$994
Santa Cruz de la SierraChicago
VVI - ORD
VVIORD
Santa Cruz de la Sierra Viru Viru Intl
Thu 5/7
3:35 am-9:20 pm
1 stop18h 45m
Chicago O'Hare Intl
Tue 5/12
11:20 pm-2:30 am
1 stop26h 10m
$994
Santa Cruz de la SierraChicago
VVI - ORD
VVIORD
Santa Cruz de la Sierra Viru Viru Intl
Sun 5/10
3:35 am-9:20 pm
1 stop18h 45m
Chicago O'Hare Intl
Sat 5/16
10:35 am-2:30 am
2 stops14h 55m
$1,035
Cheapest one-way
Santa Cruz de la SierraChicago
VVI - ORD
VVIORD
Santa Cruz de la Sierra Viru Viru Intl
Sun 5/24
3:35 am-11:40 am
2 stops33h 05m
$488
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from Santa Cruz de la Sierra to O'Hare Intl
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santa Cruz de la Sierra to O'Hare Intl in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Santa Cruz de la Sierra-Chicago O'Hare Intl Airport flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santa Cruz de la Sierra-Chicago O'Hare Intl Airport flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santa Cruz de la Sierra-Chicago O'Hare Intl Airport flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Santa Cruz de la Sierra-Chicago O'Hare Intl Airport flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santa Cruz de la Sierra-Chicago O'Hare Intl Airport flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Santa Cruz de la Sierra to O'Hare Intl
Have a flexible travel schedule? Discover the best time to fly to O'Hare Intl from Santa Cruz de la Sierra with our price prediction graph.
VVI-ORD
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Santa Cruz de la Sierra to Chicago O'Hare Intl Airport
Prices
More
What’s the top layover airport for flights from Santa Cruz de la Sierra to Chicago O'Hare Intl Airport?
Share of 1-stop round-trip flights from Santa Cruz de la Sierra to Chicago O'Hare Intl Airport chosen by Cheapflights users in the past 12 months, using the same layover each way.
Panama City (PTY) – chosen by Cheapflights users on 50% of 1-stop itineraries from Santa Cruz de la Sierra to Chicago O'Hare Intl Airport on Cheapflights.
What’s the cheapest layover airport for flights from Santa Cruz de la Sierra to Chicago O'Hare Intl Airport?
Average round-trip fare for 1-stop flights from Santa Cruz de la Sierra to Chicago O'Hare Intl Airport, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Panama City (PTY) is the most affordable 1-stop option, with an average round-trip price of $725.
What’s the fastest layover option from Santa Cruz de la Sierra to Chicago O'Hare Intl Airport?
Shortest average travel time for 1-stop one-way flights from Santa Cruz de la Sierra to Chicago O'Hare Intl Airport, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Panama City (PTY) have the shortest average one-way travel time for 1-stop routes: 13h 43m.
Which airport typically offers the quickest layover for flights from Santa Cruz de la Sierra to Chicago O'Hare Intl Airport?
Average layover duration for 1-stop one-way flights from Santa Cruz de la Sierra to Chicago O'Hare Intl Airport, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Panama City (PTY) offer the fastest connection on this route, with an average layover time of 3h 12m.
Reviews of airlines servicing O'Hare Intl
Get insights into the airlines that provide service to O'Hare Intl. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to O'Hare Intl. Reviews last updated April 26, 2026.
Get a feel of what it's like to fly with Copa Airlines from Santa Cruz de la Sierra to Chicago O'Hare Intl Airport by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.4
Crew
8.1
Entertainment
6.8
Overall
7.5
Boarding
7.8
Food
6.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Comfort
7.4
Crew
8.1
Entertainment
6.8
Overall
7.5
Boarding
7.8
Food
6.8
Reviews
1 / 20
2.0
MediocreMaria,Dec 2025
PTY - SLA
Related info for your journey
Find useful and relevant information for your journey from Santa Cruz de la Sierra to O'Hare Intl. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Chicago O'Hare Intl Airport?
Book flights to Chicago O'Hare Intl Airport if you plan to visit one of these locationsRosemont
Schaumburg
Naperville
Lake Geneva
Gurnee
Delavan
Downers Grove
Oakbrook Terrace
Benton Harbor
Hoffman Estates
Des Plaines
Oak Brook
South Holland
Libertyville
Warrenville
Elk Grove Village
Bridgeview
Great Lakes
Lansing
Arlington Heights
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Top airline flying from Santa Cruz de la Sierra to O'Hare Intl
Discover the top airline that operate flights from Santa Cruz de la Sierra to O'Hare Intl. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$690 | Average$801 | FlexibilityNo cancel fee | On-time70% |