$738+ Cheap flights from Denver (DEN) to Santa Cruz de la Sierra (VVI)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/20. Fares are subject to change and may not be available on all flights or dates of travel.
DEN — VVI
Jun 4 — Jun 111
Round-trip
1 adult, Economy
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Find cheap flights from Denver to Santa Cruz de la Sierra with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Denver to Santa Cruz de la Sierra
Cheapest
Best
Last-minute
Cheapest flights from Denver to Santa Cruz de la SierraExplore the most affordable flight options available from Denver to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 5, 2026.
Explore the most affordable flight options available from Denver to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 5, 2026.
This Copa Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2010:43 pm
DEN
- VVI
1 stop21h 57m
Copa Airlines
Sun 8/301:12 am
VVI
- DEN
1 stop19h 08m
Copa Airlines
Deal found 5/3![Copa Airlines logo]()
$738
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1112:26 pm
DEN
- VVI
2 stops32h 14m
United Airlines
Mon 8/2411:47 am
VVI
- DEN
2 stops22h 53m
United Airlines
Deal found 5/3![United Airlines logo]()
$753
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/165:00 am
DEN
- VVI
2 stops15h 40m
United Airlines
Sat 8/2911:47 am
VVI
- DEN
3 stops25h 22m
United Airlines
Deal found 5/3![United Airlines logo]()
$776
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/209:00 pm
DEN
- VVI
2 stops23h 40m
United Airlines
Mon 8/3111:47 am
VVI
- DEN
2 stops22h 37m
United Airlines
Deal found 5/3![United Airlines logo]()
$818
This Copa Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/1610:43 pm
DEN
- VVI
1 stop26h 52m
Copa Airlines
Fri 8/281:12 am
VVI
- DEN
1 stop19h 08m
Copa Airlines
Deal found 5/3![Copa Airlines logo]()
$829
This KAYAK deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2111:59 pm
DEN
- VVI
2 stops44h 45m
Copa Airlines
Mon 9/2811:47 am
VVI
- DEN
2 stops20h 55m
Copa Airlines
Deal found 4/30![Copa Airlines logo]()
$875
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/141:25 pm
DEN
- VVI
2 stops30h 25m
United Airlines
Tue 11/1711:44 am
VVI
- DEN
2 stops14h 43m
United Airlines
Deal found 4/30![United Airlines logo]()
$883
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1211:40 pm
DEN
- VVI
2 stops25h 55m
Multiple Airlines
Fri 8/288:35 am
VVI
- DEN
1 stop26h 02m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$946
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1111:40 pm
DEN
- VVI
2 stops21h 00m
Multiple Airlines
Fri 8/288:35 am
VVI
- DEN
1 stop26h 02m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$953
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1011:40 pm
DEN
- VVI
2 stops21h 00m
Multiple Airlines
Fri 8/288:35 am
VVI
- DEN
1 stop26h 02m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$980
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1211:40 pm
DEN
- VVI
1 stop26h 10m
Multiple Airlines
Mon 8/2411:35 pm
VVI
- DEN
2 stops21h 44m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$998
Best flights from Denver to Santa Cruz de la SierraDiscover carefully curated flight deals from Denver to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 5, 2026.
Discover carefully curated flight deals from Denver to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 5, 2026.
This Copa Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2010:43 pm
DEN
- VVI
1 stop21h 57m
Copa Airlines
Sun 8/301:12 am
VVI
- DEN
1 stop19h 08m
Copa Airlines
Deal found 5/3![Copa Airlines logo]()
$738
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2911:59 pm
DEN
- VVI
2 stops44h 39m
United Airlines
Tue 6/2311:47 am
VVI
- DEN
2 stops23h 00m
United Airlines
Deal found 5/3![United Airlines logo]()
$753
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2112:58 pm
DEN
- VVI
3 stops35h 32m
Multiple Airlines
Sun 9/273:35 am
VVI
- DEN
2 stops34h 44m
Multiple Airlines
Deal found 4/30![Multiple Airlines logo]()
$1,326
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1211:59 pm
DEN
- VVI
2 stops25h 36m
United Airlines
Tue 8/2511:47 am
VVI
- DEN
2 stops26h 57m
United Airlines
Deal found 5/3![United Airlines logo]()
$753
This Copa Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/1610:43 pm
DEN
- VVI
1 stop26h 52m
Copa Airlines
Fri 8/281:12 am
VVI
- DEN
1 stop19h 08m
Copa Airlines
Deal found 5/3![Copa Airlines logo]()
$829
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/209:00 pm
DEN
- VVI
2 stops23h 40m
United Airlines
Mon 8/3111:47 am
VVI
- DEN
2 stops22h 37m
United Airlines
Deal found 5/3![United Airlines logo]()
$818
This Copa Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2110:43 pm
DEN
- VVI
1 stop22h 01m
Copa Airlines
Sun 9/271:12 am
VVI
- DEN
1 stop18h 59m
Copa Airlines
Deal found 4/30![Copa Airlines logo]()
$1,148
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2110:43 pm
DEN
- VVI
1 stop22h 01m
United Airlines
Mon 9/2811:47 am
VVI
- DEN
2 stops22h 35m
United Airlines
Deal found 4/30![United Airlines logo]()
$1,111
Last-minute flights from Denver to Santa Cruz de la SierraDiscover last-minute flight deals from Denver to Santa Cruz de la Sierra. Data last updated May 5, 2026 and is based on user searches.
Discover last-minute flight deals from Denver to Santa Cruz de la Sierra. Data last updated May 5, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2911:59 pm
DEN
- VVI
2 stops44h 39m
United Airlines
Tue 6/2311:47 am
VVI
- DEN
2 stops23h 00m
United Airlines
Deal found 5/3![United Airlines logo]()
$753
This Kiwi.com deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2911:40 pm
DEN
- VVI
1 stop27h 10m
Multiple Airlines
Tue 6/236:55 pm
VVI
- DEN
2 stops49h 30m
Multiple Airlines
Deal found 5/3![Multiple Airlines logo]()
$1,190
Find flight deals from Denver to Santa Cruz de la Sierra
Discover tips and strategies to find the most affordable flight options for your journey from Denver (DEN) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 5, 2026.
Most accurate provider | Ovago 3 stars |
|---|---|
Most trusted provider | Ovago 3 stars |
Round-trip from | $738 (Copa Airlines) |
Popular in | December |
Cheapest in | October |
Average price | $712 |
Cheapflights Fare Finder
Customize your flight search to find flights from Denver to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 5, 2026.
Use the filters below to find and compare flights from Denver to Santa Cruz de la Sierra that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
DenverSanta Cruz de la Sierra
DEN - VVI
DENVVI
Denver Intl
Thu 8/20
10:43 pm-10:40 pm
1 stop21h 57m
Santa Cruz de la Sierra Viru Viru Intl
Sun 8/30
1:12 am-6:20 pm
1 stop19h 08m
$738
DenverSanta Cruz de la Sierra
DEN - VVI
DENVVI
Denver Intl
Fri 5/29
11:59 pm-10:38 pm
2 stops44h 39m
Santa Cruz de la Sierra Viru Viru Intl
Tue 6/23
11:47 am-8:47 am
2 stops23h 00m
$753
DenverSanta Cruz de la Sierra
DEN - VVI
DENVVI
Denver Intl
Wed 8/12
11:59 pm-3:35 am
2 stops25h 36m
Santa Cruz de la Sierra Viru Viru Intl
Tue 8/25
11:47 am-12:44 pm
2 stops26h 57m
$753
DenverSanta Cruz de la Sierra
DEN - VVI
DENVVI
Denver Intl
Thu 8/20
9:00 pm-10:40 pm
2 stops23h 40m
Santa Cruz de la Sierra Viru Viru Intl
Mon 8/31
11:47 am-8:24 am
2 stops22h 37m
$818
DenverSanta Cruz de la Sierra
DEN - VVI
DENVVI
Denver Intl
Sun 8/16
10:43 pm-3:35 am
1 stop26h 52m
Santa Cruz de la Sierra Viru Viru Intl
Fri 8/28
1:12 am-6:20 pm
1 stop19h 08m
$829
DenverSanta Cruz de la Sierra
DEN - VVI
DENVVI
Denver Intl
Mon 9/21
10:43 pm-10:44 pm
1 stop22h 01m
Santa Cruz de la Sierra Viru Viru Intl
Mon 9/28
11:47 am-8:22 am
2 stops22h 35m
$1,111
Quickest round-trip
DenverSanta Cruz de la Sierra
DEN - VVI
DENVVI
Denver Intl
Mon 9/21
10:43 pm-10:44 pm
1 stop22h 01m
Santa Cruz de la Sierra Viru Viru Intl
Sun 9/27
1:12 am-6:11 pm
1 stop18h 59m
$1,148
DenverSanta Cruz de la Sierra
DEN - VVI
DENVVI
Denver Intl
Mon 9/21
12:58 pm-2:30 am
3 stops35h 32m
Santa Cruz de la Sierra Viru Viru Intl
Sun 9/27
3:35 am-12:19 pm
2 stops34h 44m
$1,326
Sorted by cheapest first
Compare providers for flights from Denver to Santa Cruz de la Sierra
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Denver to Santa Cruz de la Sierra in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Denver-Santa Cruz de la Sierra flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on Denver-Santa Cruz de la Sierra flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from Denver-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Denver-Santa Cruz de la Sierra flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Denver-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Denver to Santa Cruz de la Sierra
Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Denver with our price prediction graph.
DEN-VVI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Denver to Santa Cruz de la Sierra
Reviews of airlines servicing Santa Cruz de la Sierra
Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated May 5, 2026.
Read through reviews of airlines operating flights from Denver to Santa Cruz de la Sierra, such as Copa Airlines and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.8
Crew
8.1
Food
6.8
Comfort
7.4
Entertainment
6.8
Overall
7.5
Reviews
1 / 20
10.0
ExcellentAnonymous,Apr 2026
LIM - PTY
Boarding
7.8
Crew
8.1
Food
6.8
Comfort
7.4
Entertainment
6.8
Overall
7.5
Reviews
1 / 20
10.0
ExcellentAnonymous,Apr 2026
LIM - PTY
Boarding
7.8
Crew
8.1
Food
6.8
Comfort
7.4
Entertainment
6.8
Overall
7.5
Reviews
1 / 20
10.0
ExcellentAnonymous,Apr 2026
LIM - PTY
Related info for your journey
Find useful and relevant information for your journey from Denver to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Denver to Santa Cruz de la Sierra, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Denver and Santa Cruz de la Sierra flights
Browse other Denver and Santa Cruz de la Sierra flight options. Last updated on May 5, 2026.
Other flights from Denver
Browse through other flights departing from Denver. Flights are based on user searches made on Cheapflights and were last updated on May 5, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Denver to Santa Cruz de la Sierra
Discover the top 2 airlines that operate flights from Denver to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$309 | Average$667 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$606 | Average$795 | FlexibilityNo cancel fee | On-time70% |