$86+ Cheap flights from St. Louis to Santa Ana, CA (STL - SNA)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/10. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SNA
May 23 — May 301
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Santa Ana with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Santa Ana
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Best
Last-minute
One-way
Cheapest flights from St. Louis to Santa AnaExplore the most affordable flight options available from St. Louis to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 23, 2026.
Explore the most affordable flight options available from St. Louis to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 23, 2026.
This Expedia deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:36 pm
STL
- SNA
1 stop25h 43m
Frontier
Mon 5/118:14 pm
SNA
- STL
1 stop19h 52m
Frontier
Deal found 4/18![Frontier logo]()
$185
This Expedia deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1412:36 pm
STL
- SNA
1 stop25h 43m
Frontier
Mon 5/188:14 pm
SNA
- STL
1 stop19h 52m
Frontier
Deal found 4/18![Frontier logo]()
$197
This Trip.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/39:55 pm
STL
- SNA
1 stop19h 06m
Frontier
Mon 5/118:14 pm
SNA
- STL
1 stop19h 52m
Frontier
Deal found 4/21![Frontier logo]()
$219
This Trip.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/88:08 pm
STL
- SNA
1 stop15h 01m
Frontier
Mon 5/118:14 pm
SNA
- STL
1 stop19h 52m
Frontier
Deal found 4/18![Frontier logo]()
$225
This Expedia deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:36 pm
STL
- SNA
1 stop25h 43m
Frontier
Sun 5/108:14 pm
SNA
- STL
1 stop22h 09m
Frontier
Deal found 4/18![Frontier logo]()
$230
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/278:08 pm
STL
- SNA
1 stop15h 01m
Frontier
Sun 5/318:10 pm
SNA
- STL
2 stops21h 13m
Frontier
Deal found 4/20![Frontier logo]()
$263
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/18:08 pm
STL
- SNA
2 stops47h 37m
Multiple Airlines
Mon 6/88:10 pm
SNA
- STL
1 stop18h 55m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$273
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/278:08 pm
STL
- SNA
1 stop15h 01m
Frontier
Sat 5/309:54 am
SNA
- STL
2 stops29h 39m
Frontier
Deal found 4/20![Frontier logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/278:08 pm
STL
- SNA
1 stop15h 01m
Multiple Airlines
Sun 5/317:45 am
SNA
- STL
2 stops33h 38m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$289
This CheapOair deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/228:08 pm
STL
- SNA
1 stop15h 01m
Frontier
Sun 5/249:54 am
SNA
- STL
1 stop7h 29m
Frontier
Deal found 4/20![Frontier logo]()
$290
Best flights from St. Louis to Santa AnaDiscover carefully curated flight deals from St. Louis to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 23, 2026.
Discover carefully curated flight deals from St. Louis to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 23, 2026.
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/22:27 pm
STL
- SNA
2 stops10h 02m
Delta
Sat 6/62:00 pm
SNA
- STL
1 stop7h 59m
Delta
Deal found 4/21![Delta logo]()
$426
This Southwest deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/271:45 pm
STL
- SNA
2 stops9h 40m
Southwest
Sat 5/306:45 am
SNA
- STL
2 stops13h 40m
Southwest
Deal found 4/21![Southwest logo]()
$469
This KAYAK deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/182:37 pm
STL
- SNA
1 stop5h 24m
American Airlines
Wed 5/204:23 pm
SNA
- STL
1 stop5h 49m
American Airlines
Deal found 4/20![American Airlines logo]()
$546
This Delta deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:00 am
STL
- SNA
1 stop6h 55m
Delta
Wed 5/208:00 am
SNA
- STL
1 stop6h 46m
Delta
Deal found 4/19![Delta logo]()
$442
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/26:21 am
STL
- SNA
1 stop8h 35m
Delta
Mon 7/65:03 pm
SNA
- STL
1 stop5h 36m
Delta
Deal found 4/20![Delta logo]()
$497
This Southwest deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/311:25 pm
STL
- SNA
2 stops8h 40m
Southwest
Thu 6/412:10 pm
SNA
- STL
2 stops10h 00m
Southwest
Deal found 4/18![Southwest logo]()
$547
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/203:11 pm
STL
- SNA
1 stop7h 23m
Delta
Sun 5/2412:25 pm
SNA
- STL
1 stop9h 34m
Delta
Deal found 4/21![Delta logo]()
$537
Last-minute flights from St. Louis to Santa AnaDiscover last-minute flight deals from St. Louis to Santa Ana. Data last updated April 23, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Santa Ana. Data last updated April 23, 2026 and is based on user searches.
This Trip.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/39:55 pm
STL
- SNA
1 stop19h 06m
Frontier
Mon 5/118:14 pm
SNA
- STL
1 stop19h 52m
Frontier
Deal found 4/21![Frontier logo]()
$219
This Expedia deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:36 pm
STL
- SNA
1 stop25h 43m
Frontier
Mon 5/118:14 pm
SNA
- STL
1 stop19h 52m
Frontier
Deal found 4/18![Frontier logo]()
$185
This Expedia deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:36 pm
STL
- SNA
1 stop25h 43m
Frontier
Sun 5/108:14 pm
SNA
- STL
1 stop22h 09m
Frontier
Deal found 4/18![Frontier logo]()
$230
This Trip.com deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/88:08 pm
STL
- SNA
1 stop15h 01m
Frontier
Mon 5/118:14 pm
SNA
- STL
1 stop19h 52m
Frontier
Deal found 4/18![Frontier logo]()
$225
This Expedia deal was found by Cheapflights users on 4/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1412:36 pm
STL
- SNA
1 stop25h 43m
Frontier
Mon 5/188:14 pm
SNA
- STL
1 stop19h 52m
Frontier
Deal found 4/18![Frontier logo]()
$197
This CheapOair deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/228:08 pm
STL
- SNA
1 stop15h 01m
Frontier
Sun 5/249:54 am
SNA
- STL
1 stop7h 29m
Frontier
Deal found 4/20![Frontier logo]()
$290
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/278:08 pm
STL
- SNA
1 stop15h 01m
Frontier
Sun 5/318:10 pm
SNA
- STL
2 stops21h 13m
Frontier
Deal found 4/20![Frontier logo]()
$263
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/278:08 pm
STL
- SNA
1 stop15h 01m
Frontier
Sat 5/309:54 am
SNA
- STL
2 stops29h 39m
Frontier
Deal found 4/20![Frontier logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/278:08 pm
STL
- SNA
1 stop15h 01m
Multiple Airlines
Sun 5/317:45 am
SNA
- STL
2 stops33h 38m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:08 pm
STL
- SNA
1 stop15h 01m
Frontier
Sun 5/318:10 pm
SNA
- STL
2 stops21h 13m
Frontier
Deal found 4/21![Frontier logo]()
$293
One-way flights from St. Louis to Santa AnaSearch for one-way flight options from St. Louis to Santa Ana. Find affordable one-way fares based on user searches. Data last updated April 23, 2026.
Search for one-way flight options from St. Louis to Santa Ana. Find affordable one-way fares based on user searches. Data last updated April 23, 2026.
This Expedia deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1012:36 pm
STL
- SNA
1 stop25h 43m
Frontier
Deal found 4/19![Frontier logo]()
$86
This Trip.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/159:18 pm
STL
- SNA
2 stops13h 51m
Frontier
Deal found 4/21![Frontier logo]()
$103
This CheapOair deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:36 pm
STL
- SNA
1 stop25h 43m
Frontier
Deal found 4/21![Frontier logo]()
$106
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/97:19 pm
STL
- SNA
2 stops44h 56m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/244:19 pm
STL
- SNA
2 stops18h 50m
Frontier
Deal found 4/20![Frontier logo]()
$147
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/118:08 pm
STL
- SNA
2 stops21h 15m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$160
Find flight deals from St. Louis to Santa Ana
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 23, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $185 (Expedia) |
One-way from | $86 (Expedia) |
Popular in | June |
Cheapest in | November |
Average price | $368 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
Use the filters below to find and compare flights from St. Louis to Santa Ana that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisSanta Ana
STL - SNA
STLSNA
Lambert-St Louis
Tue 6/2
2:27 pm-10:29 pm
2 stops10h 02m
Santa Ana J. Wayne/Orange Cnty
Sat 6/6
2:00 pm-11:59 pm
1 stop7h 59m
$426
St. LouisSanta Ana
STL - SNA
STLSNA
Lambert-St Louis
Thu 5/14
7:00 am-11:55 am
1 stop6h 55m
Santa Ana J. Wayne/Orange Cnty
Wed 5/20
8:00 am-4:46 pm
1 stop6h 46m
$442
St. LouisSanta Ana
STL - SNA
STLSNA
Lambert-St Louis
Wed 5/27
1:45 pm-9:25 pm
2 stops9h 40m
Santa Ana J. Wayne/Orange Cnty
Sat 5/30
6:45 am-10:25 pm
2 stops13h 40m
$469
St. LouisSanta Ana
STL - SNA
STLSNA
Lambert-St Louis
Thu 7/2
6:21 am-12:56 pm
1 stop8h 35m
Santa Ana J. Wayne/Orange Cnty
Mon 7/6
5:03 pm-12:39 am
1 stop5h 36m
$497
St. LouisSanta Ana
STL - SNA
STLSNA
Lambert-St Louis
Wed 5/20
3:11 pm-8:34 pm
1 stop7h 23m
Santa Ana J. Wayne/Orange Cnty
Sun 5/24
12:25 pm-11:59 pm
1 stop9h 34m
$537
Quickest round-trip
St. LouisSanta Ana
STL - SNA
STLSNA
Lambert-St Louis
Mon 5/18
2:37 pm-6:01 pm
1 stop5h 24m
Santa Ana J. Wayne/Orange Cnty
Wed 5/20
4:23 pm-12:12 am
1 stop5h 49m
$546
St. LouisSanta Ana
STL - SNA
STLSNA
Lambert-St Louis
Sun 5/31
1:25 pm-8:05 pm
2 stops8h 40m
Santa Ana J. Wayne/Orange Cnty
Thu 6/4
12:10 pm-12:10 am
2 stops10h 00m
$547
Cheapest one-way
St. LouisSanta Ana
STL - SNA
STLSNA
Lambert-St Louis
Thu 9/3
5:42 am-9:42 am
1 stop6h 00m
$193
St. LouisSanta Ana
STL - SNA
STLSNA
Lambert-St Louis
Tue 5/12
7:00 am-11:55 am
1 stop6h 55m
$194
St. LouisSanta Ana
STL - SNA
STLSNA
Lambert-St Louis
Mon 5/11
9:18 pm-10:54 am
3 stops39h 36m
$214
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from St. Louis to Santa Ana
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Santa Ana in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Santa Ana, California flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Santa Ana, California flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Santa Ana, California flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Santa Ana, California flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Santa Ana, California flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Santa Ana
Have a flexible travel schedule? Discover the best time to fly to Santa Ana from St. Louis with our price prediction graph.
STL-SNA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Santa Ana
Prices
More
How far ahead should I book a flight from St. Louis to Santa Ana, California?
Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Santa Ana. Price data was last updated on April 17, 2026.
To ensure you get the cheapest price possible for a flight from St. Louis to Santa Ana, California, you should look to book at least 77 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
What is the cheapest month to book a flight from St. Louis to Santa Ana, California?
Currently, November is the cheapest month in which you can book a flight from St. Louis to Santa Ana, California (average of $345). Flying from St. Louis to Santa Ana, California in June is currently the most expensive (average of $536). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from St. Louis to Santa Ana, California?
What’s the top layover airport for flights from St. Louis to Santa Ana, California?
Share of 1-stop round-trip flights from St. Louis to Santa Ana, California chosen by Cheapflights users in the past 12 months, using the same layover each way.
Denver (DEN) – chosen by Cheapflights users on 67% of 1-stop itineraries from St. Louis to Santa Ana, California on Cheapflights.
What’s the cheapest layover airport for flights from St. Louis to Santa Ana, California?
Average round-trip fare for 1-stop flights from St. Louis to Santa Ana, California, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Dallas (DFW) is the most affordable 1-stop option, with an average round-trip price of $341.
What’s the fastest layover option from St. Louis to Santa Ana, California?
Shortest average travel time for 1-stop one-way flights from St. Louis to Santa Ana, California, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Denver (DEN) have the shortest average one-way travel time for 1-stop routes: 5h 59m.
Which airport typically offers the quickest layover for flights from St. Louis to Santa Ana, California?
Average layover duration for 1-stop one-way flights from St. Louis to Santa Ana, California, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Denver (DEN) offer the fastest connection on this route, with an average layover time of 0h 55m.
Reviews of airlines servicing Santa Ana
Get insights into the airlines that provide service to Santa Ana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Ana. Reviews last updated April 23, 2026.
Peruse reviews from past customers who have flown with Southwest,United Airlines, andAmerican Airlines from St. Louis to Santa Ana to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Comfort
8.0
Overall
8.0
Food
7.0
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Comfort
8.0
Overall
8.0
Food
7.0
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Comfort
8.0
Overall
8.0
Food
7.0
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Comfort
8.0
Overall
8.0
Food
7.0
Boarding
8.1
Entertainment
7.5
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
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| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$278 | Average$390 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$286 | Average$491 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$316 | Average$500 | FlexibilityNo cancel fee | On-time63% |