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Santa Ana

$486+ Cheap flights from Florence, SC to Santa Ana, CA (FLO - SNA)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/14. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — SNA
Jan 2 — Jan 91
Fri 1/2
Fri 1/9
1 adult, Economy
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Cheap flight deals from Florence to Santa Ana

Cheapest flights from Florence to Santa Ana
Explore the most affordable flight options available from Florence to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 3, 2025.

This American Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3112:51 pmFLO - SNA
2 stops23h 09mAmerican Airlines
Tue 1/69:30 amSNA - FLO
2 stops10h 13mAmerican Airlines
Deal found 11/30$670
This American Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3112:51 pmFLO - SNA
2 stops23h 09mAmerican Airlines
Mon 1/59:59 amSNA - FLO
2 stops11h 16mAmerican Airlines
Deal found 11/30$712
This American Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/3012:51 pmFLO - SNA
2 stops23h 09mAmerican Airlines
Tue 1/67:50 amSNA - FLO
2 stops11h 53mAmerican Airlines
Deal found 11/30$718
This American Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3112:51 pmFLO - SNA
2 stops23h 09mAmerican Airlines
Fri 1/27:45 amSNA - FLO
1 stop7h 20mAmerican Airlines
Deal found 11/30$730
This American Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3112:51 pmFLO - SNA
2 stops8h 48mAmerican Airlines
Thu 1/17:45 amSNA - FLO
1 stop7h 20mAmerican Airlines
Deal found 11/30$749
This American Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3112:51 pmFLO - SNA
2 stops23h 09mAmerican Airlines
Sat 1/39:59 amSNA - FLO
2 stops11h 16mAmerican Airlines
Deal found 11/30$756
This American Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/3012:51 pmFLO - SNA
2 stops23h 09mAmerican Airlines
Wed 12/311:02 pmSNA - FLO
2 stops26h 03mAmerican Airlines
Deal found 11/30$758
This American Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/3012:51 pmFLO - SNA
2 stops23h 09mAmerican Airlines
Mon 1/59:59 amSNA - FLO
2 stops11h 16mAmerican Airlines
Deal found 11/30$760
This American Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/306:30 pmFLO - SNA
2 stops17h 30mAmerican Airlines
Fri 1/27:45 amSNA - FLO
1 stop7h 20mAmerican Airlines
Deal found 11/30$778
This American Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/295:15 amFLO - SNA
2 stops9h 41mAmerican Airlines
Sat 1/39:59 amSNA - FLO
2 stops11h 16mAmerican Airlines
Deal found 11/30$785

Find flight deals from Florence to Santa Ana

Discover tips and strategies to find the most affordable flight options for your journey from Florence (FLO) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 3, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
1 star

Round-trip from

$486
(American Airlines)
Provider with most accurate pricing for Florence-Santa Ana J. Wayne/Orange Cnty flight deals.
Search Deals
Provider most trusted by Cheapflights users for Florence-Santa Ana J. Wayne/Orange Cnty flights.
Search Deals
From Florence to Santa Ana J. Wayne/Orange Cnty
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 3, 2025.
Use the filters below to find and compare flights from Florence to Santa Ana that are best for you.

Fly from

Florence

Fly to

Santa Ana

Route

Depart

Return

Price

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Sat 2/14

5:15 am-3:44 pm

2 stops13h 29m

Santa Ana J. Wayne/Orange Cnty

Wed 2/18

7:15 am-5:23 pm

1 stop7h 08m

$486

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Wed 12/31

12:51 pm-9:00 am

2 stops23h 09m

Santa Ana J. Wayne/Orange Cnty

Tue 1/6

9:30 am-10:43 pm

2 stops10h 13m

$670

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Tue 12/30

12:51 pm-9:00 am

2 stops23h 09m

Santa Ana J. Wayne/Orange Cnty

Tue 1/6

7:50 am-10:43 pm

2 stops11h 53m

$718

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Thu 1/1

12:51 pm-9:32 am

2 stops23h 41m

Santa Ana J. Wayne/Orange Cnty

Mon 1/5

9:59 am-12:15 am

2 stops11h 16m

$743

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Wed 12/31

12:51 pm-6:39 pm

2 stops8h 48m

Santa Ana J. Wayne/Orange Cnty

Thu 1/1

7:45 am-6:05 pm

1 stop7h 20m

$749

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Wed 12/31

12:51 pm-9:00 am

2 stops23h 09m

Santa Ana J. Wayne/Orange Cnty

Sat 1/3

9:59 am-12:15 am

2 stops11h 16m

$756

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Tue 12/30

12:51 pm-9:00 am

2 stops23h 09m

Santa Ana J. Wayne/Orange Cnty

Mon 1/5

9:59 am-12:15 am

2 stops11h 16m

$760

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Tue 12/30

6:30 pm-9:00 am

2 stops17h 30m

Santa Ana J. Wayne/Orange Cnty

Fri 1/2

7:45 am-6:05 pm

1 stop7h 20m

$778

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Mon 12/29

5:15 am-11:52 am

2 stops9h 37m

Santa Ana J. Wayne/Orange Cnty

Tue 1/6

7:50 am-10:43 pm

2 stops11h 53m

$795

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Wed 12/31

6:30 pm-9:00 am

2 stops17h 30m

Santa Ana J. Wayne/Orange Cnty

Fri 1/2

6:45 am-6:05 pm

2 stops8h 20m

$796

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/2

Showing 1-10 of 11 results
1
2
  • Most accurate provider: When it comes to deals on Florence, South Carolina-Santa Ana, California flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Florence, South Carolina-Santa Ana, California flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Florence, South Carolina-Santa Ana, California flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Florence, South Carolina-Santa Ana, California flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Florence, South Carolina-Santa Ana, California flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Florence to Santa Ana

Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to Santa Ana

What is the cheapest month to book a flight from Florence, South Carolina to Santa Ana, California?

Currently, May is the cheapest month in which you can book a flight from Florence, South Carolina to Santa Ana, California (average of $91). Flying from Florence, South Carolina to Santa Ana, California in November is currently the most expensive (average of $194). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Florence to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Florence, South Carolina to Santa Ana, California?

    A quick flight from Florence, South Carolina to Santa Ana, California can take about 13h 29m. American Airlines provides one of the quickest options available for as low as $486. The distance between Florence, South Carolina and Santa Ana, California is about 2172 mi.

  • Can I find deals for flights from Florence to Santa Ana that include hotel bookings?

    Yes. In addition to deals on Florence to Santa Ana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to Santa Ana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to Santa Ana.

  • Can I find deals for business class flights from Florence to Santa Ana?

    Yes. Cheapflights offers flight deals from Florence to Santa Ana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florence, South Carolina to Santa Ana, California?

    Currently, May is the cheapest month in which you can book a flight from Florence, South Carolina to Santa Ana, California (average of $91). Flying from Florence, South Carolina to Santa Ana, California in November is currently the most expensive (average of $194). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Ana?

Book flights to Santa Ana if you plan to visit one of these locations
Tustin

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