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$524+ Cheap flights from Florence, SC to Santa Ana (FLO - SNA)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/8. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — SNA
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Florence to Santa Ana

Discover tips and strategies to find the most affordable flight options for your journey from Florence (FLO) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$524
(American Airlines)
From Florence to Santa Ana J. Wayne/Orange Cnty
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Find flight deals from Florence to Santa Ana

Cheapest flights from Florence to Santa Ana
Explore the most affordable flight options available from Florence to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/83:19 pmFLO - SNA
1 stop7h 18mAmerican Airlines
Tue 10/1410:00 amSNA - FLO
2 stops10h 13mAmerican Airlines
Deal found 9/15$524

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Florence to Santa Ana that are best for you.

Fly from

Florence

Fly to

Santa Ana

Route

Depart

Return

Price

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Wed 10/8

3:19 pm-7:37 pm

1 stop7h 18m

Santa Ana J. Wayne/Orange Cnty

Tue 10/14

10:00 am-11:13 pm

2 stops10h 13m

$524

FlorenceSanta Ana

FLO - SNA

FLOSNA

Florence

Sat 2/21

2:33 pm-8:24 pm

1 stop8h 51m

Santa Ana J. Wayne/Orange Cnty

Wed 2/25

8:16 am-11:29 pm

2 stops12h 13m

$566

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Best time to book a flight from Florence to Santa Ana

Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to Santa Ana

What is the cheapest month to book a flight from Florence, South Carolina to Santa Ana?

Currently, January is the cheapest month in which you can book a flight from Florence, South Carolina to Santa Ana (average of $298). Flying from Florence, South Carolina to Santa Ana in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Florence to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Florence, South Carolina to Santa Ana?

    There are many flights that can get you from Florence, South Carolina to Santa Ana in 7h 18m. Fly via American Airlines to get the fastest option. The distance between Florence, South Carolina and Santa Ana is about 2172 mi.

  • Can I find deals for flights from Florence to Santa Ana that include hotel bookings?

    Yes. In addition to deals on Florence to Santa Ana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to Santa Ana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to Santa Ana.

  • Can I find deals for business class flights from Florence to Santa Ana?

    Yes. Cheapflights offers flight deals from Florence to Santa Ana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florence, South Carolina to Santa Ana?

    Currently, January is the cheapest month in which you can book a flight from Florence, South Carolina to Santa Ana (average of $298). Flying from Florence, South Carolina to Santa Ana in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Ana?

Book flights to Santa Ana if you plan to visit one of these locations
Tustin

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