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$109+ Cheap flights from South Carolina to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/17. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SFO
Apr 15 — Apr 221
Wed 4/15
Wed 4/22
1 adult, Economy
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Cheap flight deals from South Carolina to San Francisco

Cheapest flights from South Carolina to San Francisco
Explore the most affordable flight options available from South Carolina to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 16, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:25 am
CHS
-
SFO
1 stop7h 37m
Breeze Airways
Mon 8/3112:18 pm
SFO
-
CHS
1 stop6h 48m
Breeze Airways
Deal found 3/15$239
This Frontier deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/164:42 pm
CLT
-
SFO
1 stop8h 49m
Frontier
Mon 4/206:00 am
SFO
-
CLT
1 stop8h 23m
Frontier
Deal found 3/14$241
This Booking.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/276:18 pm
CLT
-
SFO
1 stop9h 09m
Frontier
Mon 5/46:00 am
SFO
-
CLT
1 stop8h 23m
Frontier
Deal found 3/13$242
This Booking.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:30 pm
CLT
-
SFO
1 stop8h 57m
Frontier
Mon 4/206:00 am
SFO
-
CLT
1 stop8h 23m
Frontier
Deal found 3/11$243
This Breeze Airways deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:30 am
CHS
-
SFO
1 stop8h 07m
Breeze Airways
Wed 9/912:22 pm
SFO
-
CHS
1 stop7h 27m
Breeze Airways
Deal found 3/12$243
This Frontier deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/185:51 pm
CLT
-
SFO
1 stop18h 22m
Frontier
Sat 4/256:00 am
SFO
-
CLT
1 stop7h 56m
Frontier
Deal found 3/11$244
This CheapOair deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/297:49 pm
CLT
-
SFO
1 stop16h 24m
Frontier
Sun 5/311:16 pm
SFO
-
CLT
1 stop8h 10m
Frontier
Deal found 3/15$246
This Mytrip deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1410:00 am
CLT
-
SFO
1 stop16h 25m
Frontier
Sun 4/196:00 am
SFO
-
CLT
1 stop8h 23m
Frontier
Deal found 3/11$247
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1410:00 am
CLT
-
SFO
1 stop16h 25m
Frontier
Wed 4/157:40 pm
SFO
-
CLT
2 stops14h 58m
Frontier
Deal found 3/15$248
This Mytrip deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/157:49 pm
CLT
-
SFO
1 stop16h 24m
Frontier
Sat 4/186:00 am
SFO
-
CLT
1 stop7h 56m
Frontier
Deal found 3/11$250
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:30 pm
CLT
-
SFO
1 stop31h 55m
Frontier
Wed 4/296:29 pm
SFO
-
CLT
2 stops17h 55m
Frontier
Deal found 3/15$251
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/217:49 pm
CLT
-
SFO
2 stops28h 50m
Frontier
Sat 4/256:00 am
SFO
-
CLT
1 stop7h 56m
Frontier
Deal found 3/11$252

Find flight deals from South Carolina to San Francisco

Keep the following information in mind while searching for South Carolina to San Francisco flight deals. Data was last updated March 16, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$239
(Kiwi.com)

One-way from

$109
(Super.com)

Popular in

November

Cheapest in

October

Average price

$490
Provider with most accurate pricing for Myrtle Beach Intl-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-San Francisco flights.
Search Deals
From South Carolina to San Francisco
Search Deals
One-way flight from South Carolina to San Francisco
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($95 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
Use the filters below to find and compare flights from South Carolina to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonSan Francisco

CHS - SFO

CHSSFO

Charleston

Tue 4/14

12:00 pm-8:55 pm

1 stop11h 55m

San Francisco

Tue 4/21

5:25 am-9:05 pm

1 stop12h 40m

$282

CharlestonSan Francisco

CHS - SFO

CHSSFO

Charleston

Wed 4/15

1:15 pm-10:45 pm

2 stops12h 30m

San Francisco

Sun 4/19

9:15 pm-10:15 am

1 stop10h 00m

$302

CharlestonSan Francisco

CHS - SFO

CHSSFO

Charleston

Thu 7/9

5:55 pm-12:15 am

1 stop9h 20m

San Francisco

Mon 7/13

12:40 am-2:05 pm

1 stop10h 25m

$303

CharlestonSan Francisco

CHS - SFO

CHSSFO

Charleston

Wed 4/22

6:40 am-12:18 pm

1 stop8h 38m

San Francisco

Sun 4/26

11:20 pm-10:23 am

1 stop8h 03m

$307

CharlestonSan Francisco

CHS - SFO

CHSSFO

Charleston

Sat 5/30

4:55 pm-10:38 pm

1 stop8h 43m

San Francisco

Sat 6/6

10:55 pm-9:42 am

1 stop7h 47m

$323

CharlestonSan Francisco

CHS - SFO

CHSSFO

Charleston

Tue 5/12

6:40 am-3:20 pm

2 stops11h 40m

San Francisco

Tue 5/12

9:15 pm-11:00 am

1 stop10h 45m

$340

CharlestonSan Francisco

CHS - SFO

CHSSFO

Charleston

Wed 4/22

7:40 am-7:55 pm

2 stops15h 15m

San Francisco

Sun 4/26

5:20 am-4:00 pm

1 stop7h 40m

$346

ColumbiaSan Francisco

CAE - SFO

CAESFO

Columbia Metropolitan

Thu 5/28

3:54 pm-8:41 pm

1 stop7h 47m

San Francisco

Mon 6/1

11:59 pm-11:11 am

1 stop8h 12m

$357

SavannahSan Francisco

SAV - SFO

SAVSFO

Savannah/Hilton Head

Sat 5/2

11:20 am-9:57 pm

1 stop13h 37m

San Francisco

Tue 5/5

10:50 pm-10:35 am

1 stop8h 45m

$361

Myrtle BeachSan Francisco

MYR - SFO

MYRSFO

Myrtle Beach Intl

Tue 5/5

12:19 pm-7:07 pm

1 stop9h 48m

San Francisco

Tue 5/12

11:30 pm-10:26 am

1 stop7h 56m

$367

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/11

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from South Carolina to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to San Francisco

What is the cheapest month to book a flight from South Carolina to San Francisco?

Currently, November is the cheapest month in which you can book a flight from South Carolina to San Francisco (average of $160). Flying from South Carolina to San Francisco in February is currently the most expensive (average of $261). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SFO?

Find hourly flight availability from South Carolina to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 16, 2026.

A simple way to save on the total cost of your ticket is to fly from South Carolina to San Francisco in the afternoon. If you’re flexible enough to do this you can expect to save up to 48% on your trip compared to booking a flight in the morning.

What is the cheapest day to fly from South Carolina to San Francisco?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to San Francisco. Price data was last updated on January 24, 2026.

Travelers seeking maximum savings on their South Carolina to San Francisco flight should consider departing on Tuesday mornings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from South Carolina to San Francisco?

Related info for your journey

Find useful and relevant information for your journey from South Carolina to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Francisco from South Carolina?

    Most people fly into San Francisco (SFO) if they book a flight to San Francisco from South Carolina. San Francisco is conveniently located just 11.8 mi from San Francisco’s city center.

  • How long is the flight from South Carolina to San Francisco?

    Southwest, Delta, and United Airlines can get you from South Carolina to San Francisco in just under 8h 38m. Your travel time can differ by up to 3h 52m. The distance between South Carolina and San Francisco is about 2389 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from South Carolina to San Francisco one-way?

    One-way options have recently been found by users for as low as $81 on Viva. Other airlines that offer cheap prices include Volaris from $117 and Aeromexico from $132 one-way.

  • What are the most popular routes from South Carolina to San Francisco?

    The most popular route from South Carolina to San Francisco is Charlotte Douglas - San Francisco. You may also consider Charleston - San Francisco or Greenville - San Francisco.

  • Can I find deals for flights from South Carolina to San Francisco that include hotel bookings?

    Yes. In addition to deals on South Carolina to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to San Francisco.

  • Can I find deals for business class flights from South Carolina to San Francisco?

    Yes. Cheapflights offers flight deals from South Carolina to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to San Francisco?

    Currently, November is the cheapest month in which you can book a flight from South Carolina to San Francisco (average of $160). Flying from South Carolina to San Francisco in February is currently the most expensive (average of $261). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
South San Francisco
Santa Clara
Santa Cruz
Livermore
Roseville
Watsonville
Rancho Cordova
San Bruno
San Ramon
Sunnyvale
Vacaville
San Carlos
Redwood City
Turlock
San Lorenzo
Davis
Manteca
Union City
Elk Grove
Rohnert Park

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to San Francisco

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Top 5 airlines flying from South Carolina to San Francisco

Discover the top 5 airlines that operate flights from South Carolina to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
AirlineCheapestAverageFlexibilityOn-time
Breeze AirwaysCheapest$118Average$280FlexibilityNo cancel feeOn-timeN/A
DeltaCheapest$199Average$450FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$246Average$435FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$256Average$441FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$301Average$468FlexibilityNo cancel feeOn-time63%

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