HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Francisco

$72+ Cheap flights from Missouri to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/4. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SFO
Oct 24 — Oct 311
Fri 10/24
Fri 10/31
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Missouri to San Francisco with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Missouri to San Francisco

Keep the following information in mind while searching for Missouri to San Francisco flight deals. Data was last updated September 24, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$144
(Priceline)

One-way from

$72
(Cheapflightsfares)

Popular in

December

Cheapest in

July

Average price

$357

Good round-trip deal

$403 or less

Good one-way deal

$193 or less
Provider with most accurate pricing for Kansas City-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Kansas City-San Francisco flights.
Search Deals
From Missouri to San Francisco
Search Deals
One-way flight from Missouri to San Francisco
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($12 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals
Price to beat on a round-trip flight from Missouri to San Francisco.
Search Deals
Price to beat on a one-way flight from Missouri to San Francisco.
Search Deals

Find flight deals from Missouri to San Francisco

Cheapest flights from Missouri to San Francisco
Explore the most affordable flight options available from Missouri to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2025.

This Priceline deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/1711:37 amMCI - SFO
1 stop11h 46mFrontier
Sat 10/256:44 amSFO - MCI
1 stop9h 11mFrontier
Deal found 9/23$144
This Frontier deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/116:49 pmMCI - SFO
1 stop5h 38mFrontier
Sun 11/1610:23 pmSFO - MCI
1 stop9h 54mFrontier
Deal found 9/24$154
This Mytrip deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/88:28 pmMCI - SFO
1 stop15h 05mFrontier
Sat 11/156:34 amSFO - MCI
1 stop10h 59mFrontier
Deal found 9/24$155
This American Airlines deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/187:00 amMCI - SFO
1 stop8h 37mAmerican Airlines
Tue 11/184:21 pmSFO - MCI
1 stop5h 17mAmerican Airlines
Deal found 9/24$163
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/296:00 amMCI - SFO
1 stop8h 29mAmerican Airlines
Sat 11/1511:59 pmSFO - MCI
1 stop6h 47mAmerican Airlines
Deal found 9/23$169
This Frontier deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/247:52 pmSTL - SFO
1 stop6h 22mFrontier
Sat 11/110:23 pmSFO - STL
1 stop10h 49mFrontier
Deal found 9/22$170
This Booking.com deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/37:55 pmSTL - SFO
1 stop28h 35mFrontier
Sun 10/56:29 amSFO - STL
1 stop24h 37mFrontier
Deal found 9/22$172
This Frontier deal was found by Cheapflights users on 9/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/911:12 amMCI - SFO
1 stop11h 59mFrontier
Fri 11/146:34 amSFO - MCI
1 stop10h 59mFrontier
Deal found 9/24$172
This Frontier deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/77:45 pmSTL - SFO
1 stop6h 29mFrontier
Sun 11/96:33 pmSFO - STL
2 stops12h 34mFrontier
Deal found 9/23$177
This Frontier deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/157:02 pmMCI - SFO
2 stops15h 42mFrontier
Sat 10/186:44 amSFO - MCI
1 stop9h 11mFrontier
Deal found 9/22$177
This American Airlines deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/216:00 amMCI - SFO
1 stop8h 29mAmerican Airlines
Sat 10/2511:55 pmSFO - MCI
1 stop7h 06mAmerican Airlines
Deal found 9/23$179
This Frontier deal was found by Cheapflights users on 9/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2310:17 amSTL - SFO
1 stop7h 43mFrontier
Sat 10/253:50 pmSFO - STL
2 stops15h 32mFrontier
Deal found 9/23$183

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 24, 2025.
Use the filters below to find and compare flights from Missouri to San Francisco that are best for you.

Fly from

Missouri

Fly to

San Francisco

Route

Depart

Return

Price

Kansas CitySan Francisco

MCI - SFO

MCISFO

Kansas City

Fri 10/17

11:37 am-9:23 pm

1 stop11h 46m

San Francisco

Wed 10/22

6:34 am-5:55 pm

1 stop9h 21m

$144

Kansas CitySan Francisco

MCI - SFO

MCISFO

Kansas City

Tue 11/18

7:00 am-1:37 pm

1 stop8h 37m

San Francisco

Tue 11/18

4:21 pm-11:38 pm

1 stop5h 17m

$163

Kansas CitySan Francisco

MCI - SFO

MCISFO

Kansas City

Wed 10/15

7:02 pm-8:44 am

2 stops15h 42m

San Francisco

Sat 10/18

6:44 am-5:55 pm

1 stop9h 11m

$189

St. LouisSan Francisco

STL - SFO

STLSFO

Lambert-St Louis

Thu 11/6

6:22 pm-3:07 pm

1 stop22h 45m

San Francisco

Sun 11/9

1:45 pm-9:07 am

2 stops17h 22m

$213

Kansas CitySan Francisco

MCI - SFO

MCISFO

Kansas City

Fri 12/19

6:28 am-12:24 pm

1 stop7h 56m

San Francisco

Sun 1/4

6:10 am-3:06 pm

1 stop6h 56m

$217

Kansas CitySan Francisco

MCI - SFO

MCISFO

Kansas City

Mon 3/9

6:10 pm-11:57 pm

1 stop7h 47m

San Francisco

Tue 3/10

1:00 pm-11:10 pm

1 stop8h 10m

$237

Kansas CitySan Francisco

MCI - SFO

MCISFO

Kansas City

Thu 12/4

6:28 am-12:24 pm

1 stop7h 56m

San Francisco

Thu 12/4

5:05 pm-12:27 am

1 stop5h 22m

$237

Kansas CitySan Francisco

MCI - SFO

MCISFO

Kansas City

Thu 11/13

6:16 pm-11:55 pm

1 stop7h 39m

San Francisco

Sat 11/15

12:30 am-9:52 am

1 stop7h 22m

$237

Kansas CitySan Francisco

MCI - SFO

MCISFO

Kansas City

Tue 10/21

6:30 am-1:30 pm

1 stop9h 00m

San Francisco

Fri 10/24

12:35 am-10:08 am

1 stop7h 33m

$237

Kansas CitySan Francisco

MCI - SFO

MCISFO

Kansas City

Tue 12/23

4:05 pm-10:58 pm

1 stop8h 53m

San Francisco

Mon 12/29

1:45 pm-11:22 pm

1 stop7h 37m

$237

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/24

Showing 1-10 of 56 results
1
2
3
...
6

Best time to book a flight from Missouri to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to San Francisco

What is the cheapest month to book a flight from Missouri to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Missouri to San Francisco (average of $276). Flying from Missouri to San Francisco in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SFO?

Find hourly flight availability from Missouri to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 24, 2025.

When flying from Missouri to San Francisco, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from Missouri to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Francisco from Missouri?

    San Francisco (SFO) is the airport you will fly into if you book a flight from Missouri to San Francisco. It is only a 11.8 mi journey from San Francisco (SFO) to San Francisco’s city center.

  • How popular is this Missouri to San Francisco flight route?

    Flights from Missouri to San Francisco have been viewed 15 times in the past calendar month.

  • How long is the flight from Missouri to San Francisco?

    For as low as $217, Frontier can have you in San Francisco from Missouri in 7h 56m. Airlines will cover a distance of 1494 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Missouri to San Francisco?

    The most popular flight routes from Missouri to San Francisco are Kansas City - San Francisco, Lambert-St Louis - San Francisco and Springfield-Branson - San Francisco.

  • What are the most reliable airlines from Missouri to San Francisco?

    Before booking your flight to San Francisco from Missouri, check out the most reliable airlines to get you to your destination on time: Asiana Airlines (80%), Air New Zealand (71%), Southwest( 65%).

  • What are the cheapest flights from Missouri to San Francisco?

    On average you can expect to pay $1,176 for a flight from Missouri to San Francisco. The cheapest flight overall is $97 while the most popular route, (Kansas City - San Francisco) is currently priced at $144.

  • Can I find deals for flights from Missouri to San Francisco that include hotel bookings?

    Yes. In addition to deals on Missouri to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to San Francisco.

  • Can I find deals for business class flights from Missouri to San Francisco?

    Yes. Cheapflights offers flight deals from Missouri to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to San Francisco?

    Currently, January is the cheapest month in which you can book a flight from Missouri to San Francisco (average of $276). Flying from Missouri to San Francisco in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
Santa Cruz
Livermore
South San Francisco
Turlock
Antioch
Watsonville
Santa Clara
Manteca
Sunnyvale
Hollister
Vacaville
Foster City
Union City
Vallejo
Fairfield
Burlingame
Redwood City
San Mateo
San Leandro

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Los Angeles flights
Dallas/Fort Worth to Las Vegas flights
John F Kennedy Intl to Las Vegas flights
Seattle to Las Vegas flights
O'Hare Intl to Las Vegas flights
Newark to Las Vegas flights
Newark to Los Angeles flights
John F Kennedy Intl to San Francisco flights
San Francisco to Las Vegas flights
Dulles Intl to Las Vegas flights
San Francisco to Los Angeles flights
Seattle to Los Angeles flights
Newark to San Francisco flights
San Francisco to Santa Ana flights
Los Angeles to San Francisco flights
Atlanta to Las Vegas flights
San Francisco to Ontario flights
Reagan-National to Los Angeles flights
Dallas/Fort Worth to Los Angeles flights
LaGuardia to Los Angeles flights
Los Angeles to Las Vegas flights
Denver to Las Vegas flights
Boston to Las Vegas flights
O'Hare Intl to Los Angeles flights
Hobby to Las Vegas flights
Dulles Intl to Los Angeles flights
Midway to Las Vegas flights
Reagan-National to Las Vegas flights
Boston to Los Angeles flights
LaGuardia to Las Vegas flights
Santa Ana to San Francisco flights
Dallas/Fort Worth to San Francisco flights
San Jose to Los Angeles flights
Seattle to Ontario flights
Seattle to San Diego flights
Minneapolis to Las Vegas flights
Austin to Las Vegas flights
Santa Ana to Las Vegas flights
Portland to Los Angeles flights
Seattle to Santa Ana flights
Love Field to Las Vegas flights
Burbank to Las Vegas flights
Ontario to San Francisco flights
San Jose to Las Vegas flights
George Bush Intcntl to Las Vegas flights
Philadelphia to Las Vegas flights
John F Kennedy Intl to San Diego flights
Baltimore to Los Angeles flights
Baltimore to Las Vegas flights
O'Hare Intl to San Francisco flights

Top 6 airlines flying from Missouri to San Francisco

Discover the top 6 airlines that operate flights from Missouri to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 24, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$79Average$239FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$192Average$404FlexibilityNo cancel feeOn-time71%
DeltaCheapest$225Average$329FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$228Average$477FlexibilityNo cancel feeOn-time69%
Alaska AirlinesCheapest$256Average$348FlexibilityNo cancel feeOn-time75%
SouthwestCheapest$304Average$437FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.