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$85+ Cheap flights from Missouri to San Francisco (SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/1. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SFO
Jan 6 — Jan 131
Tue 1/6
Tue 1/13
1 adult, Economy
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Cheap flight deals from Missouri to San Francisco

Cheapest flights from Missouri to San Francisco
Explore the most affordable flight options available from Missouri to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 7, 2025.

This Frontier deal was found by Cheapflights users on 12/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2010:10 pmSTL - SFO
1 stop11h 38mFrontier
Thu 1/810:18 pmSFO - STL
1 stop11h 54mFrontier
Deal found 12/5$183
This Priceline deal was found by Cheapflights users on 12/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2010:10 pmSTL - SFO
1 stop11h 38mFrontier
Sat 1/177:00 amSFO - STL
1 stop5h 48mFrontier
Deal found 12/5$202
This Frontier deal was found by Cheapflights users on 12/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2010:10 pmSTL - SFO
1 stop11h 38mFrontier
Thu 1/16:00 amSFO - STL
1 stop8h 24mFrontier
Deal found 12/5$235
This CheapOair deal was found by Cheapflights users on 12/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/137:43 pmSTL - SFO
1 stop14h 10mFrontier
Sun 1/46:24 amSFO - STL
1 stop25h 38mFrontier
Deal found 12/5$239
This Gotogate deal was found by Cheapflights users on 12/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1210:44 pmSTL - SFO
1 stop11h 04mFrontier
Sun 12/146:00 amSFO - STL
1 stop28h 12mFrontier
Deal found 12/5$244
This Priceline deal was found by Cheapflights users on 12/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2010:10 pmSTL - SFO
1 stop11h 38mFrontier
Wed 12/2411:20 pmSFO - STL
1 stop8h 20mFrontier
Deal found 12/5$254
This Frontier deal was found by Cheapflights users on 12/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2010:10 pmSTL - SFO
1 stop11h 38mFrontier
Wed 12/3111:20 pmSFO - STL
1 stop8h 20mFrontier
Deal found 12/5$259
This Frontier deal was found by Cheapflights users on 12/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:45 pmMCI - SFO
1 stop5h 39mFrontier
Wed 12/316:24 amSFO - MCI
1 stop11h 26mFrontier
Deal found 12/6$278
This CheapOair deal was found by Cheapflights users on 12/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/177:43 pmSTL - SFO
1 stop14h 40mFrontier
Fri 1/26:24 amSFO - STL
1 stop25h 38mFrontier
Deal found 12/5$283
This Priceline deal was found by Cheapflights users on 12/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:45 pmMCI - SFO
1 stop5h 39mFrontier
Tue 12/3011:20 pmSFO - MCI
1 stop8h 48mFrontier
Deal found 12/6$284
This Frontier deal was found by Cheapflights users on 12/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/247:43 pmSTL - SFO
1 stop6h 41mFrontier
Thu 1/16:00 amSFO - STL
1 stop8h 24mFrontier
Deal found 12/5$285
This Kiwi.com deal was found by Cheapflights users on 12/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/228:52 pmSTL - SFO
1 stop24h 25mFrontier
Tue 1/64:48 pmSFO - STL
2 stops15h 14mFrontier
Deal found 12/5$302

Find flight deals from Missouri to San Francisco

Keep the following information in mind while searching for Missouri to San Francisco flight deals. Data was last updated December 7, 2025.

Most accurate provider

Gotogate
3 stars

Most trusted provider

Gotogate
3 stars

Round-trip from

$109
(WAYA)

One-way from

$85
(Kiwi.com)

Popular in

March

Cheapest in

February

Average price

$441

Good round-trip deal

$503 or less

Good one-way deal

$241 or less
Provider with most accurate pricing for Lambert-St Louis-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-San Francisco flights.
Search Deals
From Missouri to San Francisco
Search Deals
One-way flight from Missouri to San Francisco
Search Deals
High demand for flights, 3% potential price rise
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($4 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals
Price to beat on a round-trip flight from Missouri to San Francisco.
Search Deals
Price to beat on a one-way flight from Missouri to San Francisco.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 7, 2025.
Use the filters below to find and compare flights from Missouri to San Francisco that are best for you.

Fly from

Missouri

Fly to

San Francisco

Route

Depart

Return

Price

St. LouisSan Francisco

STL - SFO

STLSFO

Lambert-St Louis

Tue 1/27

5:00 pm-8:01 pm

Nonstop5h 01m

San Francisco

Thu 1/29

12:43 am-9:22 am

1 stop6h 39m

$209

St. LouisSan Francisco

STL - SFO

STLSFO

Lambert-St Louis

Tue 1/27

2:50 pm-11:03 pm

1 stop10h 13m

San Francisco

Fri 1/30

7:00 am-10:46 pm

1 stop13h 46m

$216

St. LouisSan Francisco

STL - SFO

STLSFO

Lambert-St Louis

Fri 1/16

7:27 pm-12:28 am

1 stop7h 01m

San Francisco

Mon 1/19

8:06 pm-2:46 pm

2 stops40h 40m

$220

St. LouisSan Francisco

STL - SFO

STLSFO

Lambert-St Louis

Mon 2/9

1:40 pm-12:28 am

1 stop12h 48m

San Francisco

Fri 2/13

6:15 am-10:02 am

1 stop25h 47m

$266

St. LouisSan Francisco

STL - SFO

STLSFO

Lambert-St Louis

Wed 1/14

7:00 am-5:49 pm

2 stops12h 49m

San Francisco

Wed 1/21

6:00 am-9:38 pm

2 stops13h 38m

$274

SpringfieldSan Francisco

SGF - SFO

SGFSFO

Springfield-Branson

Wed 2/4

1:28 pm-5:50 pm

1 stop6h 22m

San Francisco

Tue 2/10

7:18 am-4:27 pm

1 stop7h 09m

$289

SpringfieldSan Francisco

SGF - SFO

SGFSFO

Springfield-Branson

Wed 2/4

12:45 pm-8:10 pm

2 stops9h 25m

San Francisco

Tue 2/10

6:00 am-4:14 pm

1 stop8h 14m

$294

St. LouisSan Francisco

STL - SFO

STLSFO

Lambert-St Louis

Mon 1/5

10:10 pm-11:54 am

1 stop15h 44m

San Francisco

Mon 1/12

11:20 pm-6:51 am

1 stop29h 31m

$296

St. LouisSan Francisco

STL - SFO

STLSFO

Lambert-St Louis

Mon 1/26

3:31 pm-11:30 pm

2 stops9h 59m

San Francisco

Fri 1/30

10:30 am-11:25 pm

2 stops10h 55m

$304

St. LouisSan Francisco

STL - SFO

STLSFO

Lambert-St Louis

Mon 3/2

2:22 pm-10:41 pm

2 stops10h 19m

San Francisco

Sat 3/7

10:20 am-11:23 pm

2 stops11h 03m

$305

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/5

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to San Francisco

What is the cheapest month to book a flight from Missouri to San Francisco?

Currently, March is the cheapest month in which you can book a flight from Missouri to San Francisco (average of $118). Flying from Missouri to San Francisco in May is currently the most expensive (average of $225). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SFO?

Find hourly flight availability from Missouri to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 7, 2025.

It’s typically best to fly out from Missouri to San Francisco at noon. Doing so could potentially save you 24% on the flight price compared to flying in the afternoon, which is usually more expensive.

What is the cheapest day to fly from Missouri to San Francisco?

Use this chart to determine the cheapest time to fly round-trip from Missouri to San Francisco. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Missouri to San Francisco flight should consider departing on Tuesday evenings when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Missouri to San Francisco

Explore weekly flight availability from Missouri to San Francisco. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated December 7, 2025.

The most flights from USMO to SFO are scheduled on a Friday (6 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (3 on average).

Related info for your journey

Find useful and relevant information for your journey from Missouri to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Francisco from Missouri?

    San Francisco (SFO) is the airport you will fly into if you book a flight from Missouri to San Francisco. It is only a 11.8 mi journey from San Francisco (SFO) to San Francisco’s city center.

  • How popular is this Missouri to San Francisco flight route?

    Flights from Missouri to San Francisco have been viewed 17 times in the past calendar month.

  • How long is the flight from Missouri to San Francisco?

    For as low as $209, United Airlines can have you in San Francisco from Missouri in 5h 01m. Airlines will cover a distance of 1730 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Missouri to San Francisco?

    The most popular flight routes from Missouri to San Francisco are Lambert-St Louis - San Francisco, Kansas City - San Francisco and Springfield-Branson - San Francisco.

  • What are the most reliable airlines from Missouri to San Francisco?

    Before booking your flight to San Francisco from Missouri, check out the most reliable airlines to get you to your destination on time: SkyWest Airlines (75%), United Airlines (75%), Air New Zealand( 75%).

  • What are the cheapest flights from Missouri to San Francisco?

    On average you can expect to pay $650 for a flight from Missouri to San Francisco. The cheapest flight overall is $203 while the most popular route, (Lambert-St Louis - San Francisco) is currently priced at $155.

  • Can I find deals for flights from Missouri to San Francisco that include hotel bookings?

    Yes. In addition to deals on Missouri to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to San Francisco.

  • Can I find deals for business class flights from Missouri to San Francisco?

    Yes. Cheapflights offers flight deals from Missouri to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to San Francisco?

    Currently, March is the cheapest month in which you can book a flight from Missouri to San Francisco (average of $118). Flying from Missouri to San Francisco in May is currently the most expensive (average of $225). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
South San Francisco
Santa Cruz
Livermore
Turlock
Manteca
Watsonville
Sunnyvale
Santa Clara
San Bruno
Daly City
Redwood City
Vallejo
Hollister
Milpitas
Foster City
Union City
Davis
San Ramon
Burlingame

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Top 6 airlines flying from Missouri to San Francisco

Discover the top 6 airlines that operate flights from Missouri to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 7, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$108Average$239FlexibilityNo cancel feeOn-time62%
American AirlinesCheapest$182Average$417FlexibilityNo cancel feeOn-time71%
DeltaCheapest$213Average$335FlexibilityNo cancel feeOn-timeN/A
Alaska AirlinesCheapest$256Average$348FlexibilityNo cancel feeOn-time75%
United AirlinesCheapest$264Average$467FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$309Average$450FlexibilityNo cancel feeOn-time63%

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