$47+ Cheap flights from Missouri to San Francisco (SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/28. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SFO
Feb 27 — Mar 61
1 adult, Economy
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Cheapest flights from Missouri to San FranciscoExplore the most affordable flight options available from Missouri to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.
Explore the most affordable flight options available from Missouri to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/282:51 pm
STL
- SFO
1 stop11h 37m
Frontier
Wed 3/47:35 am
SFO
- STL
1 stop6h 18m
Frontier
Deal found 1/27![Frontier logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/210:11 pm
STL
- SFO
1 stop22h 09m
Frontier
Tue 3/109:04 pm
SFO
- STL
1 stop10h 45m
Frontier
Deal found 1/27![Frontier logo]()
$126
This WAYA deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure WAYA is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/254:39 pm
MCI
- SFO
1 stop9h 49m
Frontier
Wed 3/47:35 am
SFO
- MCI
1 stop6h 09m
Frontier
Deal found 1/26![Frontier logo]()
$126
This Frontier deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/184:39 pm
MCI
- SFO
1 stop9h 49m
Frontier
Wed 2/257:20 am
SFO
- MCI
1 stop6h 24m
Frontier
Deal found 1/26![Frontier logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:12 pm
STL
- SFO
1 stop23h 36m
Frontier
Tue 3/109:04 pm
SFO
- STL
1 stop10h 45m
Frontier
Deal found 1/26![Frontier logo]()
$143
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/45:18 pm
STL
- SFO
1 stop9h 10m
Frontier
Sun 3/89:04 pm
SFO
- STL
1 stop10h 45m
Frontier
Deal found 1/27![Frontier logo]()
$145
This Frontier deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/2310:55 am
MCI
- SFO
1 stop12h 44m
Frontier
Thu 2/266:15 am
SFO
- MCI
1 stop12h 14m
Frontier
Deal found 1/27![Frontier logo]()
$148
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/278:33 pm
MCI
- SFO
1 stop13h 30m
Multiple Airlines
Mon 3/28:16 pm
SFO
- MCI
1 stop25h 17m
Multiple Airlines
Deal found 1/26![Multiple Airlines logo]()
$157
This Expedia deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2610:11 pm
STL
- SFO
1 stop11h 37m
Frontier
Sat 2/286:15 am
SFO
- STL
1 stop5h 41m
Frontier
Deal found 1/27![Frontier logo]()
$158
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/146:41 pm
STL
- SFO
2 stops22h 23m
Frontier
Wed 2/257:20 am
SFO
- STL
1 stop6h 33m
Frontier
Deal found 1/26![Frontier logo]()
$164
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/288:41 pm
MCI
- SFO
1 stop13h 22m
Multiple Airlines
Mon 3/28:16 pm
SFO
- MCI
1 stop25h 17m
Multiple Airlines
Deal found 1/26![Multiple Airlines logo]()
$174
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/44:39 pm
MCI
- SFO
2 stops16h 41m
Frontier
Sun 3/89:04 pm
SFO
- MCI
1 stop20h 49m
Frontier
Deal found 1/26![Frontier logo]()
$180
Find flight deals from Missouri to San Francisco
Keep the following information in mind while searching for Missouri to San Francisco flight deals. Data was last updated January 28, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $123 (Kiwi.com) |
One-way from | $47 (Trip.com) |
Popular in | March |
Cheapest in | April |
Average price | $399 |
Good round-trip deal | $468 or less |
Good one-way deal | $241 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Missouri to San Francisco that are best for you.
Fly from
Missouri
Fly to
San Francisco
Route
Depart
Return
Price
St. LouisSan Francisco
STL - SFO
STLSFO
Lambert-St Louis
Fri 3/20
8:12 pm-12:28 am
1 stop30h 16m
San Francisco
Mon 3/30
10:48 pm-9:48 am
2 stops33h 00m
$244
St. LouisSan Francisco
STL - SFO
STLSFO
Lambert-St Louis
Sun 3/8
6:19 pm-8:39 pm
1 stop28h 20m
San Francisco
Sun 3/15
10:40 pm-1:34 pm
1 stop12h 54m
$270
St. LouisSan Francisco
STL - SFO
STLSFO
Lambert-St Louis
Tue 3/3
2:22 pm-10:41 pm
2 stops10h 19m
San Francisco
Thu 3/5
10:20 am-11:23 pm
2 stops11h 03m
$274
St. LouisSan Francisco
STL - SFO
STLSFO
Lambert-St Louis
Fri 2/27
2:22 pm-10:41 pm
2 stops10h 19m
San Francisco
Mon 3/2
10:20 am-12:25 am
2 stops12h 05m
$274
Kansas CitySan Francisco
MCI - SFO
MCISFO
Kansas City
Thu 4/16
7:00 am-9:05 am
Nonstop4h 05m
San Francisco
Mon 4/20
11:52 pm-10:27 am
1 stop8h 35m
$279
SpringfieldSan Francisco
SGF - SFO
SGFSFO
Springfield-Branson
Tue 2/17
6:05 pm-11:47 pm
1 stop7h 42m
San Francisco
Sun 3/1
12:30 am-8:59 am
1 stop6h 29m
$289
SpringfieldSan Francisco
SGF - SFO
SGFSFO
Springfield-Branson
Fri 4/24
6:30 pm-12:19 am
1 stop7h 49m
San Francisco
Tue 4/28
10:50 pm-10:39 am
1 stop9h 49m
$289
SpringfieldSan Francisco
SGF - SFO
SGFSFO
Springfield-Branson
Tue 3/24
5:00 pm-10:47 pm
1 stop7h 47m
San Francisco
Wed 4/8
6:40 am-4:26 pm
1 stop7h 46m
$289
Kansas CitySan Francisco
MCI - SFO
MCISFO
Kansas City
Fri 3/6
2:24 pm-6:19 pm
1 stop5h 55m
San Francisco
Sun 3/8
6:00 am-2:54 pm
1 stop6h 54m
$289
SpringfieldSan Francisco
SGF - SFO
SGFSFO
Springfield-Branson
Mon 3/23
6:08 pm-12:16 am
1 stop8h 08m
San Francisco
Tue 4/7
5:00 am-2:17 pm
1 stop7h 17m
$289
Showing 1-10 of 60 results
Best time to book a flight from Missouri to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to San Francisco
What is the cheapest month to book a flight from Missouri to San Francisco?
Currently, March is the cheapest month in which you can book a flight from Missouri to San Francisco (average of $118). Flying from Missouri to San Francisco in May is currently the most expensive (average of $225). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to SFO?
Find hourly flight availability from Missouri to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 28, 2026.
It’s typically best to fly out from Missouri to San Francisco at noon. Doing so could potentially save you 58% on the flight price compared to flying in the evening, which is usually more expensive.
Weekly flight availability from Missouri to San Francisco
Explore weekly flight availability from Missouri to San Francisco. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated January 28, 2026.
The most flights from USMO to SFO are scheduled on a Monday (6 on average). You will have fewer flight options on Wednesday, which is when the least amount of flights are scheduled (1 on average).
Related info for your journey
Find useful and relevant information for your journey from Missouri to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Cruz
Roseville
Santa Clara
Livermore
Watsonville
San Bruno
Daly City
Sunnyvale
Turlock
Vacaville
San Carlos
San Ramon
Manteca
Vallejo
San Lorenzo
Davis
Hollister
Redwood City
Union City
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Missouri to San Francisco
See prices for flight routes from nearby airports that may be better suited for you.
Top 6 airlines flying from Missouri to San Francisco
Discover the top 6 airlines that operate flights from Missouri to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$76 | Average$226 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$167 | Average$333 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$176 | Average$430 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$248 | Average$348 | FlexibilityNo cancel fee | On-time75% | |
| Cheapest$278 | Average$421 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$284 | Average$458 | FlexibilityNo cancel fee | On-time63% |