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$140+ Cheap flights from Greenville to San Francisco (GSP - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/18. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — SFO
Feb 7 — Feb 141
Sat 2/7
Sat 2/14
1 adult, Economy
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Cheap flight deals from Greenville to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 8, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$279
(Delta)

One-way from

$140
(American Airlines)

Popular in

January

Cheapest in

August

Average price

$618
Provider with most accurate pricing for Greenville-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-San Francisco flights.
Search Deals
From Greenville to San Francisco
Search Deals
One-way flight from Greenville to San Francisco
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($65 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($13 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Greenville to San Francisco

Cheapest flights from Greenville to San Francisco
Explore the most affordable flight options available from Greenville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 8, 2026.

This Delta deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/285:26 pmGSP - SFO
1 stop8h 59mDelta
Wed 2/112:05 pmSFO - GSP
1 stop6h 45mDelta
Deal found 1/7$279
This American Airlines deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/44:40 pmGSP - SFO
1 stop9h 32mAmerican Airlines
Wed 2/119:10 amSFO - GSP
2 stops8h 46mAmerican Airlines
Deal found 1/7$284
This Southwest deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/310:05 amGSP - SFO
2 stops11h 00mSouthwest
Tue 2/179:30 pmSFO - GSP
1 stop10h 10mSouthwest
Deal found 1/5$299
This American Airlines deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/104:26 pmGSP - SFO
2 stops9h 48mAmerican Airlines
Tue 3/177:25 amSFO - GSP
1 stop8h 31mAmerican Airlines
Deal found 1/8$301
This Delta deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/296:50 amGSP - SFO
1 stop9h 05mDelta
Tue 2/175:45 amSFO - GSP
1 stop9h 14mDelta
Deal found 1/7$311
This Delta deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/285:26 pmGSP - SFO
1 stop8h 59mDelta
Tue 2/172:39 pmSFO - GSP
2 stops15h 26mDelta
Deal found 1/7$317
This American Airlines deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/24:26 pmGSP - SFO
1 stop8h 41mAmerican Airlines
Tue 3/312:30 amSFO - GSP
2 stops9h 45mAmerican Airlines
Deal found 1/8$321
This United Airlines deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/35:34 pmGSP - SFO
1 stop8h 26mUnited Airlines
Tue 2/1711:55 pmSFO - GSP
1 stop8h 26mUnited Airlines
Deal found 1/5$327
This American Airlines deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/74:40 pmGSP - SFO
1 stop9h 32mAmerican Airlines
Wed 2/116:00 amSFO - GSP
1 stop6h 50mAmerican Airlines
Deal found 1/7$328

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 8, 2026.
Use the filters below to find and compare flights from Greenville to San Francisco that are best for you.

Fly from

Greenville

Fly to

San Francisco

Route

Depart

Return

Price

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Tue 2/3

10:05 am-6:05 pm

2 stops11h 00m

San Francisco

Tue 2/17

9:30 pm-10:40 am

1 stop10h 10m

$299

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Tue 3/10

7:14 am-2:23 pm

1 stop10h 09m

San Francisco

Mon 3/16

12:30 am-1:15 pm

2 stops9h 45m

$332

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Tue 1/27

12:00 pm-5:43 pm

1 stop8h 43m

San Francisco

Tue 2/17

10:00 pm-9:05 am

1 stop8h 05m

$345

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Thu 1/29

5:40 am-1:43 pm

2 stops11h 03m

San Francisco

Wed 2/4

2:05 pm-11:50 pm

1 stop6h 45m

$349

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Mon 3/2

10:45 am-8:15 pm

2 stops12h 30m

San Francisco

Wed 3/4

5:35 pm-11:45 am

2 stops15h 10m

$379

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Thu 4/16

5:12 pm-11:09 pm

1 stop8h 57m

San Francisco

Sat 5/23

12:36 pm-10:55 pm

1 stop7h 19m

$395

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Fri 3/20

5:00 am-12:17 pm

1 stop10h 17m

San Francisco

Mon 3/23

11:29 pm-10:56 am

1 stop8h 27m

$395

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Mon 1/26

5:12 pm-11:25 pm

1 stop9h 13m

San Francisco

Wed 2/11

2:05 pm-11:50 pm

1 stop6h 45m

$397

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Sat 4/18

12:25 pm-9:55 pm

2 stops12h 30m

San Francisco

Wed 4/22

11:25 pm-1:15 pm

2 stops10h 50m

$398

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Thu 4/30

6:25 pm-12:20 am

2 stops8h 55m

San Francisco

Sat 5/23

9:15 pm-10:10 am

1 stop9h 55m

$400

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/8

Showing 1-10 of 22 results
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Compare providers for flights from Greenville to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to San Francisco in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
JustAirTicketPrice Accuracy-Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Greenville-San Francisco flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Greenville-San Francisco flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Greenville-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Greenville-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Greenville to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to San Francisco

How far ahead should I book a flight from Greenville to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Greenville to San Francisco. Price data was last updated on January 2, 2026.

The price you pay for your flight from Greenville to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 72 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Greenville to San Francisco?

Currently, August is the cheapest month in which you can book a flight from Greenville to San Francisco (average of $106). Flying from Greenville to San Francisco in December is currently the most expensive (average of $338). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated January 8, 2026.
Read through reviews of airlines operating flights from Greenville to San Francisco, such as Southwest, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,248 reviews

Boarding

8.1

Comfort

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,248 reviews
Southwest
8.0
Very good
4,248 reviews

Boarding

8.1

Comfort

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
7.9
Good
8,025 reviews
Southwest
8.0
Very good
4,248 reviews

Boarding

8.1

Comfort

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
9,139 reviews
Southwest
8.0
Very good
4,248 reviews

Boarding

8.1

Comfort

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
11,095 reviews
Southwest
8.0
Very good
4,248 reviews

Boarding

8.1

Comfort

8.0

Food

7.0

Crew

8.6

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Greenville to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to San Francisco?

    There are many flights that can get you from Greenville to San Francisco in 8h 43m. Fly via Southwest, American Airlines, or Delta to get the fastest option. The distance from Greenville to San Francisco is about 2227 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Greenville to San Francisco round-trip?

    Currently priced at $276, Delta will fly you from Greenville to San Francisco and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from United Airlines and Southwest - these airlines can fly you to your destination from $311 and $330, respectively. Delta is priced at 42% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Greenville to San Francisco one-way?

    To fly one-way, consider booking your trip with Delta, which is currently one of the cheapest options available, starting at $153. American Airlines flights start at $168 while deals on United Airlines start at $175 one-way.

  • Can I find deals for flights from Greenville to San Francisco that include hotel bookings?

    Yes. In addition to deals on Greenville to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to San Francisco.

  • Can I find deals for business class flights from Greenville to San Francisco?

    Yes. Cheapflights offers flight deals from Greenville to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to San Francisco?

    Currently, August is the cheapest month in which you can book a flight from Greenville to San Francisco (average of $106). Flying from Greenville to San Francisco in December is currently the most expensive (average of $338). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
South San Francisco
Santa Cruz
Santa Clara
Livermore
Watsonville
Redwood City
Sunnyvale
San Bruno
Daly City
Manteca
Turlock
San Carlos
San Ramon
Vallejo
San Lorenzo
Hollister
Foster City
Union City
Davis

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Top 4 airlines flying from Greenville to San Francisco

Discover the top 4 airlines that operate flights from Greenville to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 8, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$276Average$446FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$311Average$488FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$330Average$488FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$332Average$480FlexibilityNo cancel feeOn-time71%

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