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$180+ Cheap flights from Greenville to San Francisco (GSP - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/11. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — SFO
Oct 19 — Oct 261
Sun 10/19
Sun 10/26
1 adult, Economy
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Cheapflights Tip: The best prices from Greenville to San Francisco are usually found in August or January, booked 72 days in advance, depart on a Wednesday or Tuesday and return on a Saturday

Cheap flight deals from Greenville to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 19, 2025.

Round-trip from

$337
(United Airlines)

One-way from

$180
(United Airlines)

Popular in

March

Cheapest in

August

Average price

$443
From Greenville to San Francisco
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One-way flight from Greenville to San Francisco
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Highest demand for flights based on searches. 8% potential increase in price ($43 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Greenville to San Francisco

Cheapest flights from Greenville to San Francisco
Explore the most affordable flight options available from Greenville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 19, 2025.

This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/224:29 pmGSP - SFO
1 stop7h 25mUnited Airlines
Wed 10/296:45 amSFO - GSP
1 stop9h 25mUnited Airlines
Deal found 9/17$337
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/87:40 amGSP - SFO
1 stop8h 40mSouthwest
Wed 12/109:25 pmSFO - GSP
1 stop9h 35mSouthwest
Deal found 9/17$348
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/67:57 pmGSP - SFO
1 stop7h 38mAmerican Airlines
Mon 11/1011:59 pmSFO - GSP
1 stop8h 05mAmerican Airlines
Deal found 9/17$359
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/68:00 amGSP - SFO
2 stops13h 15mSouthwest
Mon 11/109:25 pmSFO - GSP
1 stop9h 35mSouthwest
Deal found 9/17$364
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/175:00 pmGSP - SFO
1 stop9h 57mUnited Airlines
Fri 10/2411:00 pmSFO - GSP
1 stop9h 46mUnited Airlines
Deal found 9/17$379
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/226:05 amGSP - SFO
1 stop10h 25mSouthwest
Wed 10/295:45 amSFO - GSP
2 stops9h 45mSouthwest
Deal found 9/17$382
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:44 pmGSP - SFO
1 stop9h 37mUnited Airlines
Thu 12/256:00 amSFO - GSP
1 stop8h 01mUnited Airlines
Deal found 9/17$423
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/171:50 pmGSP - SFO
2 stops13h 15mSouthwest
Fri 10/249:05 pmSFO - GSP
1 stop9h 50mSouthwest
Deal found 9/17$424

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 19, 2025.
Use the filters below to find and compare flights from Greenville to San Francisco that are best for you.

Fly from

Greenville

Fly to

San Francisco

Route

Depart

Return

Price

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Wed 10/22

4:29 pm-8:54 pm

1 stop7h 25m

San Francisco

Wed 10/29

6:45 am-7:10 pm

1 stop9h 25m

$337

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Mon 12/8

7:40 am-1:20 pm

1 stop8h 40m

San Francisco

Wed 12/10

9:25 pm-10:00 am

1 stop9h 35m

$348

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Thu 11/6

7:57 pm-12:35 am

1 stop7h 38m

San Francisco

Mon 11/10

11:59 pm-11:04 am

1 stop8h 05m

$359

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Thu 11/6

8:00 am-6:15 pm

2 stops13h 15m

San Francisco

Mon 11/10

9:25 pm-10:00 am

1 stop9h 35m

$364

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Wed 10/22

6:05 am-1:30 pm

1 stop10h 25m

San Francisco

Wed 10/29

5:45 am-6:30 pm

2 stops9h 45m

$382

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Wed 12/24

5:44 pm-12:21 am

1 stop9h 37m

San Francisco

Thu 12/25

6:00 am-5:01 pm

1 stop8h 01m

$423

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Wed 12/24

7:40 am-1:20 pm

1 stop8h 40m

San Francisco

Thu 12/25

5:50 am-7:50 pm

2 stops11h 00m

$424

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Wed 11/26

5:35 am-12:30 pm

1 stop9h 55m

San Francisco

Mon 12/1

9:30 pm-9:03 am

1 stop8h 33m

$447

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Thu 10/2

2:34 pm-8:28 pm

1 stop8h 54m

San Francisco

Thu 10/9

9:50 pm-8:59 am

1 stop8h 09m

$453

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Mon 12/22

7:00 am-2:29 pm

1 stop10h 29m

San Francisco

Sat 12/27

10:30 pm-9:18 am

1 stop7h 48m

$453

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/18

Showing 1-10 of 19 results
1
2

Best time to book a flight from Greenville to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to San Francisco

How far ahead should I book a flight from Greenville to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Greenville to San Francisco. Price data was last updated on September 12, 2025.

The price you pay for your flight from Greenville to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 72 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Greenville to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Greenville to San Francisco (average of $276). Flying from Greenville to San Francisco in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to SFO?

Find hourly flight availability from Greenville to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 19, 2025.

One of the essential ways to save on airfare from Greenville to San Francisco is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the morning could potentially save you up to 6% on airfare.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated September 19, 2025.
Read through reviews of airlines operating flights from Greenville to San Francisco, such as Southwest, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,242 reviews

Food

7.0

Comfort

8.0

Crew

8.6

Overall

8.0

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,242 reviews
Southwest
8.0
Very good
4,242 reviews

Food

7.0

Comfort

8.0

Crew

8.6

Overall

8.0

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
8.0
Very good
7,964 reviews
Southwest
8.0
Very good
4,242 reviews

Food

7.0

Comfort

8.0

Crew

8.6

Overall

8.0

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
8,926 reviews
Southwest
8.0
Very good
4,242 reviews

Food

7.0

Comfort

8.0

Crew

8.6

Overall

8.0

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,242 reviews

Food

7.0

Comfort

8.0

Crew

8.6

Overall

8.0

Boarding

8.1

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Greenville to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to San Francisco?

    There are many flights that can get you from Greenville to San Francisco in 7h 25m. Fly via United Airlines, Southwest, or American Airlines to get the fastest option. The distance from Greenville to San Francisco is about 2227 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Greenville to San Francisco round-trip?

    Currently priced at $276, Delta will fly you from Greenville to San Francisco and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from United Airlines and Southwest - these airlines can fly you to your destination from $312 and $330, respectively. Delta is priced at 40% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Greenville to San Francisco that include hotel bookings?

    Yes. In addition to deals on Greenville to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to San Francisco.

  • Can I find deals for business class flights from Greenville to San Francisco?

    Yes. Cheapflights offers flight deals from Greenville to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to San Francisco?

    Currently, January is the cheapest month in which you can book a flight from Greenville to San Francisco (average of $276). Flying from Greenville to San Francisco in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
Santa Cruz
Livermore
South San Francisco
Turlock
Antioch
Watsonville
Santa Clara
Manteca
Sunnyvale
Hollister
Vacaville
Foster City
Union City
Vallejo
Burlingame
Redwood City
San Mateo
San Leandro
Lathrop

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Top 4 airlines flying from Greenville to San Francisco

Discover the top 4 airlines that operate flights from Greenville to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 19, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$276Average$444FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$312Average$456FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$330Average$488FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$340Average$479FlexibilityNo cancel feeOn-time71%

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