HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
San Francisco

$142+ Cheap flights from Greenville to San Francisco (GSP - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/14. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — SFO
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Greenville to San Francisco with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Greenville to San Francisco are usually found in January or August, booked 77 days in advance, depart on a Wednesday or Tuesday and return on a Saturday

Cheap flight deals from Greenville to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 14, 2025.

Round-trip from

$283
(Delta)

One-way from

$142
(Delta)

Popular in

March

Cheapest in

January

Average price

$412
From Greenville to San Francisco
Search Deals
One-way flight from Greenville to San Francisco
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($41 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2025
Search Deals

Find flight deals from Greenville to San Francisco

Cheapest flights from Greenville to San Francisco
Explore the most affordable flight options available from Greenville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/97:05 amGSP - SFO
1 stop10h 22mDelta
Wed 9/171:37 pmSFO - GSP
1 stop6h 57mDelta
Deal found 8/13$283
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/96:00 amGSP - SFO
1 stop10h 05mAmerican Airlines
Wed 9/1710:15 amSFO - GSP
2 stops9h 15mAmerican Airlines
Deal found 8/13$288
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/112:09 pmGSP - SFO
1 stop9h 39mDelta
Sat 10/47:00 amSFO - GSP
1 stop8h 35mDelta
Deal found 8/13$304
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/285:30 amGSP - SFO
1 stop8h 04mDelta
Wed 10/111:57 pmSFO - GSP
1 stop6h 16mDelta
Deal found 8/14$310
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/272:04 pmGSP - SFO
1 stop7h 44mDelta
Sat 10/47:00 amSFO - GSP
1 stop8h 35mDelta
Deal found 8/13$325
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/610:20 amGSP - SFO
2 stops10h 55mSouthwest
Mon 11/109:25 pmSFO - GSP
1 stop9h 35mSouthwest
Deal found 8/12$330
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/46:33 pmGSP - SFO
1 stop7h 42mAmerican Airlines
Sun 9/76:00 amSFO - GSP
1 stop6h 34mAmerican Airlines
Deal found 8/14$331
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/217:00 amGSP - SFO
1 stop7h 38mUnited Airlines
Wed 9/249:10 amSFO - GSP
1 stop9h 50mUnited Airlines
Deal found 8/14$336
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/75:06 amGSP - SFO
1 stop10h 10mAmerican Airlines
Fri 9/1212:14 pmSFO - GSP
1 stop7h 16mAmerican Airlines
Deal found 8/13$337
This Southwest deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/41:50 pmGSP - SFO
1 stop9h 20mSouthwest
Wed 9/105:55 amSFO - GSP
2 stops9h 10mSouthwest
Deal found 8/14$349
This Southwest deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/910:25 amGSP - SFO
2 stops9h 20mSouthwest
Wed 9/175:25 pmSFO - GSP
2 stops13h 30mSouthwest
Deal found 8/13$351

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Greenville to San Francisco that are best for you.

Fly from

Greenville

Fly to

San Francisco

Route

Depart

Return

Price

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Wed 9/17

8:00 am-2:36 pm

1 stop9h 36m

San Francisco

Wed 9/24

5:00 am-3:46 pm

1 stop7h 46m

$283

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Tue 9/9

7:05 am-2:27 pm

1 stop10h 22m

San Francisco

Wed 9/17

1:37 pm-11:34 pm

1 stop6h 57m

$283

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Wed 9/17

6:33 pm-11:15 pm

1 stop7h 42m

San Francisco

Tue 9/23

12:47 am-10:56 am

1 stop7h 09m

$283

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Tue 9/9

2:15 pm-6:52 pm

1 stop7h 37m

San Francisco

Tue 9/16

1:37 pm-11:34 pm

1 stop6h 57m

$283

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Tue 9/9

6:00 am-1:05 pm

1 stop10h 05m

San Francisco

Wed 9/17

10:15 am-10:30 pm

2 stops9h 15m

$288

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Thu 9/4

5:30 am-10:10 am

1 stop7h 40m

San Francisco

Wed 9/10

7:00 am-7:23 pm

1 stop9h 23m

$304

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Tue 9/23

6:33 pm-11:15 pm

1 stop7h 42m

San Francisco

Sat 9/27

11:52 pm-10:33 am

1 stop7h 41m

$304

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Wed 10/1

12:09 pm-5:32 pm

1 stop8h 23m

San Francisco

Sat 10/4

7:00 am-6:35 pm

1 stop8h 35m

$304

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Wed 9/10

5:30 am-10:10 am

1 stop7h 40m

San Francisco

Thu 9/25

11:57 pm-9:13 am

1 stop6h 16m

$304

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Wed 10/15

5:30 pm-9:56 pm

1 stop7h 26m

$142

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/12

Showing 1-10 of 21 results
1
2
3

Best time to book a flight from Greenville to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to San Francisco

How far ahead should I book a flight from Greenville to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Greenville to San Francisco. Price data was last updated on August 8, 2025.

The price you pay for your flight from Greenville to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 77 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Greenville to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Greenville to San Francisco (average of $276). Flying from Greenville to San Francisco in June is currently the most expensive (average of $358). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to SFO?

Find hourly flight availability from Greenville to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

One of the essential ways to save on airfare from Greenville to San Francisco is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the morning could potentially save you up to 6% on airfare.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated August 14, 2025.
Read through reviews of airlines operating flights from Greenville to San Francisco, such as Southwest, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,244 reviews

Crew

8.6

Comfort

8.0

Boarding

8.1

Overall

8.0

Entertainment

7.5

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,244 reviews
Southwest
8.0
Very good
4,244 reviews

Crew

8.6

Comfort

8.0

Boarding

8.1

Overall

8.0

Entertainment

7.5

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
8.0
Very good
7,980 reviews
Southwest
8.0
Very good
4,244 reviews

Crew

8.6

Comfort

8.0

Boarding

8.1

Overall

8.0

Entertainment

7.5

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
8,916 reviews
Southwest
8.0
Very good
4,244 reviews

Crew

8.6

Comfort

8.0

Boarding

8.1

Overall

8.0

Entertainment

7.5

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,244 reviews

Crew

8.6

Comfort

8.0

Boarding

8.1

Overall

8.0

Entertainment

7.5

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Greenville to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Greenville to San Francisco round-trip?

    Currently priced at $312, United Airlines will fly you from Greenville to San Francisco and back. In addition to United Airlines, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from Delta and American Airlines - these airlines can fly you to your destination from $312 and $334, respectively. United Airlines is priced at 32% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Greenville to San Francisco that include hotel bookings?

    Yes. In addition to deals on Greenville to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to San Francisco.

  • Can I find deals for business class flights from Greenville to San Francisco?

    Yes. Cheapflights offers flight deals from Greenville to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to San Francisco?

    Currently, January is the cheapest month in which you can book a flight from Greenville to San Francisco (average of $276). Flying from Greenville to San Francisco in June is currently the most expensive (average of $358). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
Santa Cruz
Livermore
South San Francisco
Mountain View
Turlock
Santa Clara
Hollister
Antioch
Watsonville
Manteca
Sunnyvale
Newark
Milpitas
Campbell
Foster City
San Leandro
Burlingame
Redwood City
Vallejo

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Greenville to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to Las Vegas flights
Charlotte to Los Angeles flights
Charlotte to San Francisco flights
Savannah to Las Vegas flights
Charleston to Las Vegas flights
Charlotte to Ontario flights
Greenville to Las Vegas flights
Charlotte to Burbank flights
Hilton Head Island to Las Vegas flights
Charlotte to San Diego flights
Charlotte to Santa Ana flights
Augusta to Las Vegas flights
Charleston to San Francisco flights
Charlotte to Sacramento flights
Myrtle Beach to Las Vegas flights
Columbia to Las Vegas flights
Charleston to San Diego flights
Charleston to Los Angeles flights
Greenville to San Diego flights
Charlotte to Reno flights
Myrtle Beach to Los Angeles flights
Savannah to San Diego flights
Charleston to Ontario flights
Charlotte to Palm Springs flights
Charlotte to San Jose flights
Savannah to Los Angeles flights
Columbia to San Diego flights
Savannah to San Francisco flights
Greenville to Los Angeles flights
Columbia to San Francisco flights
Charlotte to Fresno flights
Myrtle Beach to San Diego flights
Charlotte to Oakland flights
Columbia to Ontario flights
Columbia to Los Angeles flights
Charleston to Burbank flights
Greenville to Ontario flights
Greenville to Santa Ana flights
Greenville to Sacramento flights
Augusta to Los Angeles flights
Greenville to San Jose flights
Myrtle Beach to Ontario flights
Savannah to Santa Ana flights
Columbia to San Jose flights
Charleston to Sacramento flights
Augusta to San Francisco flights
Myrtle Beach to San Francisco flights
Charleston to Santa Ana flights
Myrtle Beach to Burbank flights

Top 4 airlines flying from Greenville to San Francisco

Discover the top 4 airlines that operate flights from Greenville to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$312Average$487FlexibilityNo cancel feeOn-time69%
DeltaCheapest$312Average$448FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$334Average$479FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$366Average$506FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.