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$162+ Cheap flights from Greenville to San Francisco (GSP - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/5. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — SFO
Dec 21 — Dec 281
Sun 12/21
Sun 12/28
1 adult, Economy
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Cheapflights Tip: The best prices from Greenville to San Francisco are usually found in August or January, booked 72 days in advance, depart on a Wednesday or Tuesday and return on a Saturday

Find flight deals from Greenville to San Francisco

Cheapest flights from Greenville to San Francisco
Explore the most affordable flight options available from Greenville to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 21, 2025.

This United Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:44 pmGSP - SFO
1 stop9h 37mUnited Airlines
Wed 12/3111:05 pmSFO - GSP
1 stop8h 51mUnited Airlines
Deal found 11/19$359
This Kiwi.com deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/810:01 amGSP - SFO
1 stop12h 52mMultiple Airlines
Wed 12/1010:10 pmSFO - GSP
2 stops37h 00mMultiple Airlines
Deal found 11/20$403
This American Airlines deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/156:00 amGSP - SFO
1 stop10h 34mAmerican Airlines
Sat 1/312:22 amSFO - GSP
1 stop6h 49mAmerican Airlines
Deal found 11/20$432
This United Airlines deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/265:44 pmGSP - SFO
1 stop9h 37mUnited Airlines
Tue 12/3011:05 pmSFO - GSP
1 stop8h 51mUnited Airlines
Deal found 11/20$434
This Kiwi.com deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1510:01 amGSP - SFO
1 stop12h 52mMultiple Airlines
Sun 1/46:00 amSFO - GSP
2 stops35h 08mMultiple Airlines
Deal found 11/20$463
This Southwest deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/243:05 pmGSP - SFO
2 stops10h 25mSouthwest
Wed 12/319:25 pmSFO - GSP
1 stop9h 35mSouthwest
Deal found 11/19$470
This United Airlines deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/55:28 pmGSP - SFO
1 stop8h 09mUnited Airlines
Tue 12/95:00 amSFO - GSP
1 stop7h 15mUnited Airlines
Deal found 11/20$472
This Southwest deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/157:40 amGSP - SFO
1 stop8h 40mSouthwest
Sun 1/49:25 pmSFO - GSP
1 stop9h 20mSouthwest
Deal found 11/20$476
This American Airlines deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/512:06 pmGSP - SFO
2 stops10h 08mAmerican Airlines
Tue 12/97:15 amSFO - GSP
1 stop8h 58mAmerican Airlines
Deal found 11/20$477
This Southwest deal was found by Cheapflights users on 11/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/87:40 amGSP - SFO
2 stops10h 00mSouthwest
Wed 12/105:50 amSFO - GSP
2 stops10h 50mSouthwest
Deal found 11/20$482

Cheap flight deals from Greenville to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 21, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$335
(Delta)

One-way from

$162
(Kiwi.com)

Popular in

March

Cheapest in

August

Average price

$429
Provider with most accurate pricing for Greenville-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-San Francisco flights.
Search Deals
From Greenville to San Francisco
Search Deals
One-way flight from Greenville to San Francisco
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($59 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 21, 2025.
Use the filters below to find and compare flights from Greenville to San Francisco that are best for you.

Fly from

Greenville

Fly to

San Francisco

Route

Depart

Return

Price

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Wed 1/28

3:05 pm-8:25 pm

1 stop8h 20m

San Francisco

Sat 1/31

12:04 pm-10:24 pm

1 stop7h 20m

$335

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Wed 12/24

5:44 pm-12:21 am

1 stop9h 37m

San Francisco

Wed 12/31

11:05 pm-10:56 am

1 stop8h 51m

$359

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Tue 2/24

6:30 am-2:07 pm

1 stop10h 37m

San Francisco

Fri 2/27

10:50 pm-10:06 am

1 stop8h 16m

$407

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Tue 2/24

11:15 am-6:05 pm

2 stops9h 50m

San Francisco

Fri 2/27

9:30 pm-10:00 am

1 stop9h 30m

$412

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Fri 12/26

5:44 pm-12:21 am

1 stop9h 37m

San Francisco

Tue 12/30

11:05 pm-10:56 am

1 stop8h 51m

$434

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Wed 1/28

6:00 am-1:46 pm

2 stops10h 46m

San Francisco

Sat 1/31

9:00 am-7:07 pm

1 stop7h 07m

$440

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Wed 5/6

10:44 am-5:13 pm

1 stop9h 29m

San Francisco

Mon 5/11

10:35 pm-9:49 am

1 stop8h 14m

$442

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Thu 4/23

7:55 pm-12:15 am

1 stop7h 20m

San Francisco

Mon 4/27

10:30 pm-9:28 am

1 stop7h 58m

$447

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Tue 4/21

5:45 am-10:26 am

1 stop7h 41m

San Francisco

Tue 4/28

11:30 am-9:25 pm

1 stop6h 55m

$447

GreenvilleSan Francisco

GSP - SFO

GSPSFO

Greenville

Wed 12/24

5:44 pm-12:21 am

1 stop9h 37m

San Francisco

Thu 1/1

5:15 am-5:03 pm

1 stop8h 48m

$459

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/19

Showing 1-10 of 21 results
1
2
3

Compare providers for flights from Greenville to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to San Francisco in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
JustAirTicketPrice Accuracy-Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Greenville-San Francisco flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Greenville-San Francisco flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Greenville-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Greenville-San Francisco flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Greenville to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to San Francisco

How far ahead should I book a flight from Greenville to San Francisco?

Use this chart to determine the optimal time to book a round-trip flight from Greenville to San Francisco. Price data was last updated on November 14, 2025.

The price you pay for your flight from Greenville to San Francisco may vary depending on when you book. For the best chance of a lower fare, look to book 72 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Greenville to San Francisco?

Currently, August is the cheapest month in which you can book a flight from Greenville to San Francisco (average of $106). Flying from Greenville to San Francisco in December is currently the most expensive (average of $309). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to SFO?

Find hourly flight availability from Greenville to San Francisco. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 21, 2025.

One of the essential ways to save on airfare from Greenville to San Francisco is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the morning could potentially save you up to 33% on airfare.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated November 21, 2025.
Read through reviews of airlines operating flights from Greenville to San Francisco, such as Southwest, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,251 reviews

Crew

8.6

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Overall

8.0

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,251 reviews
Southwest
8.0
Very good
4,251 reviews

Crew

8.6

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Overall

8.0

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
7.9
Good
8,002 reviews
Southwest
8.0
Very good
4,251 reviews

Crew

8.6

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Overall

8.0

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
9,028 reviews
Southwest
8.0
Very good
4,251 reviews

Crew

8.6

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Overall

8.0

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
11,047 reviews
Southwest
8.0
Very good
4,251 reviews

Crew

8.6

Comfort

8.0

Entertainment

7.5

Boarding

8.1

Overall

8.0

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Greenville to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to San Francisco?

    There are many flights that can get you from Greenville to San Francisco in 8h 20m. Fly via Delta, United Airlines, or Southwest to get the fastest option. The distance from Greenville to San Francisco is about 2227 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Greenville to San Francisco round-trip?

    Currently priced at $276, Delta will fly you from Greenville to San Francisco and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Search Cheapflights for deals from United Airlines and Southwest - these airlines can fly you to your destination from $311 and $330, respectively. Delta is priced at 40% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Greenville to San Francisco that include hotel bookings?

    Yes. In addition to deals on Greenville to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to San Francisco.

  • Can I find deals for business class flights from Greenville to San Francisco?

    Yes. Cheapflights offers flight deals from Greenville to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to San Francisco?

    Currently, August is the cheapest month in which you can book a flight from Greenville to San Francisco (average of $106). Flying from Greenville to San Francisco in December is currently the most expensive (average of $309). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
Roseville
South San Francisco
Santa Cruz
Livermore
Turlock
Manteca
Watsonville
Sunnyvale
Santa Clara
Vallejo
Hollister
San Bruno
Foster City
Redwood City
Union City
Burlingame
Lodi
San Mateo
Vacaville
Lathrop

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Top 4 airlines flying from Greenville to San Francisco

Discover the top 4 airlines that operate flights from Greenville to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 21, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$276Average$440FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$311Average$488FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$330Average$488FlexibilityNo cancel feeOn-time63%
American AirlinesCheapest$340Average$487FlexibilityNo cancel feeOn-time71%

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